55524
2017
2016
eng
24
40
17
1
8
review
Royal Society of Chemistry
Cambridge
1
2016-09-03
2016-09-03
--
Thermoresponsive poly(2-oxazoline)s, polypeptoids, and polypeptides
This review covers the recent advances in the emerging field of thermoresponsive polyamides or polymeric amides, i.e., poly(2-oxazoline)s, polypeptoids, and polypeptides, with a specific focus on structure-thermoresponsive property relationships, self-assembly, and applications.
Polymer Chemistry
10.1039/c6py01320a
1759-9954
1759-9962
wos:2017
WOS:000391732800003
Hoogenboom, R (reprint author), Univ Ghent, Dept Organ & Macromol Chem, Supramol Chem Grp, Krijgslaan 281 S4, B-9000 Ghent, Belgium.; Schlaad, H (reprint author), Univ Potsdam, Inst Chem, Karl Liebknecht Str 24-25, D-14476 Potsdam, Germany., richard.hoogenboom@ugent.be; schlaad@uni-potsdam.de
2022-07-08T08:50:00+00:00
sword
importub
filename=package.tar
0ee913a41b792fcdab9e94d2c7bbe931
Hoogenboom, Richard
Schlaad, Helmut
<a href="http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-395022">Zweitveröffentlichung in der Schriftenreihe Postprints der Universität Potsdam : Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe ; 328 </a>
Richard Hoogenboom
Helmut Schlaad
Chemie und zugeordnete Wissenschaften
Institut für Chemie
Referiert
Import
54236
2018
2018
eng
4007
4019
13
33
25
review
Bentham Science Publishers LTD
Sharjah
1
--
--
--
Electrochemical MIP-Sensors for Drugs
In order to replace bio-macromolecules by stable synthetic materials in separation techniques and bioanalysis biomimetic receptors and catalysts have been developed: Functional monomers are polymerized together with the target analyte and after template removal cavities are formed in the "molecularly imprinted polymer" (MIP) which resemble the active sites of antibodies and enzymes. Starting almost 80 years ago, around 1,100 papers on MIPs were published in 2016. Electropolymerization allows to deposit MIPs directly on voltammetric electrodes or chips for quartz crystal microbalance (QCM) and surface plasmon resonance (SPR). For the readout of MIPs for drugs amperometry, differential pulse voltammetry (DPV) and impedance spectroscopy (EIS) offer higher sensitivity as compared with QCM or SPR. Application of simple electrochemical devices allows both the reproducible preparation of MIP sensors, but also the sensitive signal generation. Electrochemical MIP-sensors for the whole arsenal of drugs, e.g. the most frequently used analgesics, antibiotics and anticancer drugs have been presented in literature and tested under laboratory conditions. These biomimetic sensors typically have measuring ranges covering the lower nano-up to millimolar concentration range and they are stable under extreme pH and in organic solvents like nonaqueous extracts.
Current Medicinal Chemistry
10.2174/0929867324666171005103712
28982312
0929-8673
1875-533X
wos:2018
WOS:000448120700005
Yarman, A (reprint author), Turkish German Univ, Fac Sci Mol Biotechnol, Sahinkaya Cad 86, TR-34820 Istanbul, Turkey.; Scheller, FW (reprint author), Univ Potsdam, Inst Biochem & Biol, Karl Liebknecht Str 25-26, D-14476 Potsdam, Germany., aysu.yarman@yahoo.de; fschell@uni-potsdam.de
Deutsche Forschungsgemeinschaft (DFG)German Research Foundation (DFG) [UniCat/EXC 314]; ERACHEM [61133]
2022-03-09T14:27:17+00:00
sword
importub
filename=package.tar
a84940be32f439c4fbc9328612f60a3a
false
true
Aysu Yarman
Sevinc Kurbanoglu
Katharina J. Jetzschmann
Sibel A. Ozkan
Ulla Wollenberger
Frieder W. Scheller
eng
uncontrolled
Biomimetic sensors
eng
uncontrolled
molecularly imprinted polymers
eng
uncontrolled
drug sensors
eng
uncontrolled
drug imprinting
eng
uncontrolled
electropolymerization
eng
uncontrolled
electrochemical sensors
Chemie und zugeordnete Wissenschaften
Institut für Chemie
Referiert
Import
52658
2018
2018
eng
183
190
8
104
review
Elsevier
Oxford
1
2018-11-15
2018-11-15
--
The crux of inept biomarkers for risks and benefits of trace elements
Nowadays, the role of trace elements (TE) is of growing interest because dyshomeostasis of selenium (Se), manganese (Mn), zinc (Zn), and copper (Cu) is supposed to be a risk factor for several diseases. Thereby, research focuses on identifying new biomarkers for the TE status to allow for a more reliable description of the individual TE and health status. This review mirrors a lack of well-defined, sensitive, and selective biomarkers and summarizes technical limitations to measure them. Thus, the capacity to assess the relationship between dietary TE intake, homeostasis, and health is restricted, which would otherwise provide the basis to define adequate intake levels of single TE in both healthy and diseased humans. Besides that, our knowledge is even more limited with respect to the real life situation of combined TE intake and putative interactions between single TE.
Trends in Analytical Chemistry
10.1016/j.trac.2017.11.007
0165-9936
1879-3142
wos:2018
WOS:000438004400017
Schwerdtle, T (reprint author), Univ Potsdam, Inst Nutr Sci, Arthur Scheunert Allee 114-116, D-14558 Nuthetal, Germany., tanja.schwerdtle@uni-potsdam.de
NutriAct - Competence Cluster Nutrition Research Berlin-Potsdam - Federal Ministry of Education and Research [FKZ: 01EA1408B]; TraceAge - DFG Research Unit on Interactions of essential trace elements in healthy and diseased elderly, Potsdam Berlin-Jena [FOR 2558/1]; "Deutsche Forschungsgemeinschaft" (DFG)German Research Foundation (DFG) [Schw 903/9-1, BO 4103/2-1]
2021-11-15T14:50:53+00:00
sword
importub
filename=package.tar
47a9c2f609739702687fe2f7c07e6c1f
Schwerdtle, Tanja
false
true
Julia Bornhorst
Anna P. Kipp
Hajo Haase
Soeren Meyer
Tanja Schwerdtle
eng
uncontrolled
Trace elements
eng
uncontrolled
Copper
eng
uncontrolled
Zinc
eng
uncontrolled
Manganese
eng
uncontrolled
Selenium
eng
uncontrolled
Biomarker
eng
uncontrolled
Inductively coupled plasma mass spectrometry
eng
uncontrolled
Hyphenated techniques
eng
uncontrolled
Isotope ratios
Chemie und zugeordnete Wissenschaften
Institut für Chemie
Institut für Ernährungswissenschaft
Referiert
Import
52536
2018
2018
eng
548
558
11
7
2
review
Wiley-VCH
Weinheim
1
2018-02-27
2018-02-27
--
Release of Singlet Oxygen from Organic Peroxides under Mild Conditions
Singlet oxygen can be released in the dark in nearly quantitative yield from endoperoxides of naphthalenes, anthracenes and pyridones as an alternative to its generation by photosensitization. Recently, new donor systems have been designed which operate at very low temperatures but which are prepared from their parent forms at acceptable rates. Enhancement of the reactivity of donors is conveniently achieved by the design of the substitution pattern or through the use of plasmonic heating of nanoparticle-bound donors. The most important aim of these donor molecules is to transfer singlet oxygen in a controlled and directed manner to a target. Low temperatures and the linking between donors and acceptors reduce the random walk of oxygen and may force an attack at the desired position. By using chiral donor systems, new stereocenters might be introduced into prochiral acceptors.
ChemPhotoChem
10.1002/cptc.201700235
2367-0932
wos:2018
WOS:000438496400004
Linker, T (reprint author), Univ Potsdam, Dept Chem, Karl Liebknecht Str 24-25, D-14476 Potsdam, Germany., linker@uni-potsdam.de
2021-11-08T12:28:34+00:00
sword
importub
filename=package.tar
61941911a98db275436e815555c90815
false
true
Werner Fudickar
Torsten Linker
eng
uncontrolled
donor-acceptor systems
eng
uncontrolled
oxygenation
eng
uncontrolled
peroxides
eng
uncontrolled
polycycles
eng
uncontrolled
retro reactions
Chemie und zugeordnete Wissenschaften
Institut für Chemie
Referiert
Import
52293
2018
2018
eng
35
59
25
368
review
Elsevier
Lausanne
1
2018-04-27
--
--
Critical overview on the structure and metabolism of human aldehyde oxidase and its role in pharmacokinetics
Aldehyde oxidases are molybdenum and flavin dependent enzymes characterized by a very wide substrate specificity and performing diverse reactions that include oxidations (e.g., aldehydes and azaheterocycles), hydrolysis of amide bonds, and reductions (e.g., nitro, S-oxides and N-oxides). Oxidation reactions and amide hydrolysis occur at the molybdenum site while the reductions are proposed to occur at the flavin site. AOX activity affects the metabolism of different drugs and xenobiotics, some of which designed to resist other liver metabolizing enzymes (e.g., cytochrome P450 monooxygenase isoenzymes), raising its importance in drug development. This work consists of a comprehensive overview on aldehyde oxidases, concerning the genetic evolution of AOX, its diversity among the human population, the crystal structures available, the known catalytic reactions and the consequences in pre-clinical pharmacokinetic and pharmacodynamic studies. Analysis of the different animal models generally used for pre-clinical trials and comparison between the human (hAOX1), mouse homologs as well as the related xanthine oxidase (XOR) are extensively considered. The data reviewed also include a systematic analysis of representative classes of molecules that are hAOX1 substrates as well as of typical and well characterized hAOX1 inhibitors. The considerations made on the basis of a structural and functional analysis are correlated with reported kinetic and metabolic data for typical classes of drugs, searching for potential structural determinants that may dictate substrate and/or inhibitor specificities.
Coordination chemistry reviews
10.1016/j.ccr.2018.04.006
0010-8545
1873-3840
wos:2018
WOS:000433642700003
Romao, MJ (reprint author), Univ Nova Lisboa, Dept Quim, UCIBIO Requimte, Fac Ciencias & Tecnol, P-2829516 Caparica, Portugal., mjr@fct.unl.pt
Fundacao para a Ciencia e TecnologiaPortuguese Foundation for Science and Technology [PTDC/BBB-BEP/1185/2014, UID/Multi/04378/2013, SFRH/BPD/84581/2012]; ERDFEuropean Union (EU) [POCI-01-0145-FEDER-007728]; Associazione Italiana per la Ricerca contro it Cancro (AIRC)Associazione Italiana per la Ricerca sul Cancro (AIRC); Fondazione Italo Monzino; Deutsche Forschungsgemeinschaft (DFG)German Research Foundation (DFG) [LE1171/8-3]
2021-10-19T09:28:13+00:00
sword
importub
filename=package.tar
e2b463586728f10d53d4939daa42d5bd
Romao, Maria Joao
false
true
Cristiano Mota
Catarina Coelho
Silke Leimkühler
Enrico Garattini
Mineko Terao
Teresa Santos-Silva
Maria Joao Romao
eng
uncontrolled
Drug metabolism
eng
uncontrolled
Aldehyde oxidase
eng
uncontrolled
Xenobiotics
eng
uncontrolled
Molybdoenzymes
eng
uncontrolled
Non-CYP enzymes
eng
uncontrolled
Hepatic clearance
Chemie und zugeordnete Wissenschaften
Institut für Chemie
Referiert
Import
50308
2018
2018
eng
151
158
8
55
review
Elsevier
London
1
2018-10-13
--
--
Analytical epigenetics
The field of epigenetics describes the relationship between genotype and phenotype, by regulating gene expression without changing the canonical base sequence of DNA. It deals with molecular genomic information that is encoded by a rich repertoire of chemical modifications and molecular interactions. This regulation involves DNA, RNA and proteins that are enzymatically tagged with small molecular groups that alter their physical and chemical properties. It is now clear that epigenetic alterations are involved in development and disease, and thus, are the focus of intensive research. The ability to record epigenetic changes and quantify them in rare medical samples is critical for next generation diagnostics. Optical detection offers the ultimate single-molecule sensitivity and the potential for spectral multiplexing. Here we review recent progress in ultrasensitive optical detection of DNA and histone modifications.
Current Opinion in Biotechnology
single-molecule optical detection of DNA and histone modifications
10.1016/j.copbio.2018.09.006
30326408
0958-1669
1879-0429
wos:2019
WOS:000459949400020
Ebenstein, Y (reprint author), Tel Aviv Univ, Raymond & Beverly Sackler Fac Exact Sci, Sch Chem, Tel Aviv, Israel.; Bald, I (reprint author), Univ Potsdam, Inst Chem, Karl Liebknecht Str 24-25, D-14476 Potsdam, Germany.; Bald, I (reprint author), BAM Fed Inst Mat Res & Testing, Richard Willstatter Str 11, D-12489 Berlin, Germany., uv@post.tau.ac.il; bald@uni-potsdam.de
BeyondSey consortium (EC program) [634890]; European Research Council starter grant [337830]; European Research Council Proof of Concept grant by the EC-Horizon2020 program [767931]; NIH-R21 grant [1R21ES028015-01]; ERC Consolidator Grant [772752]; German Research Foundation (DEG)German Research Foundation (DFG) [BA4026/5-2]
2021-04-14T09:09:56+00:00
sword
importub
filename=package.tar
fae77a0275383e8fc46169b9d843c845
Bald, Ilko
Ebenstein, Yuval
false
true
Christian Heck
Yael Michaeli
Ilko Bald
Yuval Ebenstein
Chemie und zugeordnete Wissenschaften
Institut für Chemie
Referiert
Import
Green Open-Access
49361
2017
2017
eng
34
77
44
74
review
Elsevier
Oxford
1
2017-07-15
--
--
Macromolecular architectures through organocatalysis
In virtue of the rising demand for metal-free polymeric materials, organocatalytic polymerization has emerged and blossomed unprecedentedly in the past 15 years into an appealing research area and a powerful arsenal for polymer synthesis. In addition to the inherent merits as being metal-free, small molecule organocatalysts have also provided opportunities to develop alternative and, in many cases, more expedient synthetic approaches toward macromolecular architectures, that play a crucial role in shaping the properties of the obtained polymers. A majority of preliminary studies exploring for new catalysts, catalytic mechanisms and optimized polymerization conditions are extended to application of the catalytic systems on rational design and controlled synthesis of various macromolecular architectures. Such endeavors are described in this review, categorized by the architectural elements including chain structure (types, sequence and composition of monomeric units constituting the polymer chains), topological structure (the fashion different polymer chains are covalently attached to each other within the macromolecule) and functionality (position and amount of functional groups that endow the entire macromolecule with specific chemical, physico-chemical or biological properties). (C) 2017 Published by Elsevier B.V.
Progress in Polymer Science
10.1016/j.progpolymsci.2017.07.002
0079-6700
1873-1619
wos:2017
WOS:000414113200002
Zhao, JP (reprint author), South China Univ Technol, Fac Mat Sci & Engn, 381 Wushan Rd, Guangzhou 510640, Guangdong, Peoples R China.; Schlaad, H (reprint author), Univ Potsdam, Inst Chem, Karl Liebknecht Str 24-25, D-14476 Potsdam, Germany., msjpzhao@scut.edu.cn; schlaad@uni-potsdam.de
National Natural Science Foundation of China [21674038, 21504024]; Fundamental Research Funds for Central Universities [2017ZD072]
2021-02-10T13:57:09+00:00
sword
importub
filename=package.tar
e17eef7e1105a871970d5641c66b0002
Zhao, Junpeng
Schlaad, Helmut
false
true
Shuangyan Hu
Junpeng Zhao
Guangzhao Zhang
Helmut Schlaad
eng
uncontrolled
Organocatalytic polymerization
eng
uncontrolled
Metal-free polymerization
eng
uncontrolled
Macromolecular architecture
eng
uncontrolled
Controlled polymer synthesis
Chemie und zugeordnete Wissenschaften
Institut für Chemie
Referiert
Import
48034
2019
2019
eng
17
21
8
review
Wiley
Hoboken
1
2019-11-07
--
--
In Vitro Thrombogenicity Testing of Biomaterials
The short- and long-term thrombogenicity of implant materials is still unpredictable, which is a significant challenge for the treatment of cardiovascular diseases. A knowledge-based approach for implementing biofunctions in materials requires a detailed understanding of the medical device in the biological system. In particular, the interplay between material and blood components/cells as well as standardized and commonly acknowledged in vitro test methods allowing a reproducible categorization of the material thrombogenicity requires further attention. Here, the status of in vitro thrombogenicity testing methods for biomaterials is reviewed, particularly taking in view the preparation of test materials and references, the selection and characterization of donors and blood samples, the prerequisites for reproducible approaches and applied test systems. Recent joint approaches in finding common standards for a reproducible testing are summarized and perspectives for a more disease oriented in vitro thrombogenicity testing are discussed.
Advanced healthcare materials
10.1002/adhm.201900527
31612646
2192-2640
2192-2659
wos:2019
1900527
WOS:000489903300001
Jung, F (reprint author), Helmholtz Zentrum Geesthacht, Inst Biomat Sci, Kantstr 55, D-14513 Teltow, Germany.; Jung, F (reprint author), Helmholtz Zentrum Geesthacht, Berlin Brandenburg Ctr Regenerat Therapies BCRT, Kantstr 55, D-14513 Teltow, Germany.; Jung, F (reprint author), Helmholtz Zentrum Geesthacht, Helmholtz Virtual Inst Multifunct Biomat Med, Kantstr 55, D-14513 Teltow, Germany., friedrich.jung@hzg.de
Federal Ministry of Education and Research, GermanyFederal Ministry of Education & Research (BMBF) [13GW0098]; Helmholtz-AssociationHelmholtz Association [SO-036, VH-VI-423]; Ministry for Science, Research and Cultural Affairs of Brandenburg through the grant of the project "Konsequenzen der altersassoziierten Zell- und Organfunktionen" of the Gesundheitscampus Brandenburg [GeCa: H228-05/002/008]
importub
2020-10-27T13:38:24+00:00
filename=package.tar
89a4ae34d19195a199806f563150bd01
false
true
Steffen Braune
Robert A. Latour
Markus Reinthaler
Ulf Landmesser
Andreas Lendlein
Friedrich Jung
eng
uncontrolled
biomaterials
eng
uncontrolled
blood tests
eng
uncontrolled
implants
eng
uncontrolled
in vitro
eng
uncontrolled
thrombogenicity
Biowissenschaften; Biologie
Institut für Chemie
Referiert
Open Access
Import
Hybrid Open-Access
48011
2019
2019
eng
20
52
31
review
Wiley-VCH
Weinheim
1
2019-12-23
2019-10-21
--
Nonradiative Recombination in Perovskite Solar Cells
Perovskite solar cells combine high carrier mobilities with long carrier lifetimes and high radiative efficiencies. Despite this, full devices suffer from significant nonradiative recombination losses, limiting their V-OC to values well below the Shockley-Queisser limit. Here, recent advances in understanding nonradiative recombination in perovskite solar cells from picoseconds to steady state are presented, with an emphasis on the interfaces between the perovskite absorber and the charge transport layers. Quantification of the quasi-Fermi level splitting in perovskite films with and without attached transport layers allows to identify the origin of nonradiative recombination, and to explain the V-OC of operational devices. These measurements prove that in state-of-the-art solar cells, nonradiative recombination at the interfaces between the perovskite and the transport layers is more important than processes in the bulk or at grain boundaries. Optical pump-probe techniques give complementary access to the interfacial recombination pathways and provide quantitative information on transfer rates and recombination velocities. Promising optimization strategies are also highlighted, in particular in view of the role of energy level alignment and the importance of surface passivation. Recent record perovskite solar cells with low nonradiative losses are presented where interfacial recombination is effectively overcome-paving the way to the thermodynamic efficiency limit.
Advanced materials
the Role of Interfaces
10.1002/adma.201902762
31631441
0935-9648
1521-4095
wos:2019
1902762
WOS:000491107000001
Wolff, CM; Stolterfoht, M; Neher, D (reprint author), Univ Potsdam, Inst Phys & Astron, Karl Liebknecht Str 24-25, D-14476 Potsdam, Germany., chriwolff@uni-potsdam.de; stolterf@uni-potsdam.de; neher@uni-potsdam.de
HyPerCells, a joint gradate school of the University of Potsdam; Helmholtz-Zentrum Berlin
importub
2020-10-25T10:41:52+00:00
filename=package.tar
b4f1786a1acdae47cc6380bd346f9a3e
Christian Michael Wolff
Pietro Caprioglio
Martin Stolterfoht
Dieter Neher
eng
uncontrolled
interfacial recombination
eng
uncontrolled
open-circuit voltage
eng
uncontrolled
perovskite solar cells
eng
uncontrolled
photoluminescence
Chemie und zugeordnete Wissenschaften
Institut für Chemie
Referiert
Open Access
Import
Hybrid Open-Access
46683
2017
2017
eng
18
14
review
Royal Society
London
1
--
--
--
Evaluating polymeric biomaterial-environment interfaces by Langmuir monolayer techniques
Polymeric biomaterials are of specific relevance in medical and pharmaceutical applications due to their wide range of tailorable properties and functionalities. The knowledge about interactions of biomaterials with their biological environment is of crucial importance for developing highly sophisticated medical devices. To achieve optimal in vivo performance, a description at the molecular level is required to gain better understanding about the surface of synthetic materials for tailoring their properties. This is still challenging and requires the comprehensive characterization of morphological structures, polymer chain arrangements and degradation behaviour. The review discusses selected aspects for evaluating polymeric biomaterial-environment interfaces by Langmuir monolayer methods as powerful techniques for studying interfacial properties, such as morphological and degradation processes. The combination of spectroscopic, microscopic and scattering methods with the Langmuir techniques adapted to polymers can substantially improve the understanding of their in vivo behaviour.
Interface : journal of the Royal Society
10.1098/rsif.2016.1028
1742-5689
1742-5662
wos:2017
20161028
WOS:000402534200005
Lendlein, A (reprint author), Univ Potsdam, Inst Chem, Karl Liebknecht Str 24-25, D-14476 Potsdam, Germany.; Lendlein, A (reprint author), Helmholtz Zentrum Geesthacht, Inst Biomat Sci, Kantstr 55, D-14513 Teltow, Germany.; Lendlein, A (reprint author), Helmholtz Zentrum Geesthacht, Berlin Brandenburg Ctr Regenerat Therapies BCRT, Kantstr 55, D-14513 Teltow, Germany.; Lendlein, A (reprint author), Helmholtz Virtual Inst Multifunct Biomat Med, Kantstr 55, D-14513 Teltow, Germany., andreas.lendlein@hzg.de
Helmholtz Association [VH-VI-423]
importub
2020-04-20T03:31:01+00:00
filename=package.tar
2921def7437c0e73a270df3e7cd6b16a
Anne-Christin Schöne
Toralf Roch
Burkhard Schulz
Andreas Lendlein
eng
uncontrolled
Langmuir monolayer
eng
uncontrolled
biodegradable polymers
eng
uncontrolled
air - water interface
eng
uncontrolled
protein Langmuir layers
Institut für Chemie
Referiert
Import