36442
2011
2011
eng
7
23
10
article
BioMed Central
London
1
--
--
--
Vitamin A metabolism is changed in donors after living-kidney transplantation an observational study
Background: The kidneys are essential for the metabolism of vitamin A (retinol) and its transport proteins retinol-binding protein 4 (RBP4) and transthyretin. Little is known about changes in serum concentration after living donor kidney transplantation (LDKT) as a consequence of unilateral nephrectomy; although an association of these parameters with the risk of cardiovascular diseases and insulin resistance has been suggested. Therefore we analyzed the concentration of retinol, RBP4, apoRBP4 and transthyretin in serum of 20 living-kidney donors and respective recipients at baseline as well as 6 weeks and 6 months after LDKT.
Results: As a consequence of LDKT, the kidney function of recipients was improved while the kidney function of donors was moderately reduced within 6 weeks after LDKT. With regard to vitamin A metabolism, the recipients revealed higher levels of retinol, RBP4, transthyretin and apoRBP4 before LDKT in comparison to donors. After LDKT, the levels of all four parameters decreased in serum of the recipients, while retinol, RBP4 as well as apoRBP4 serum levels of donors increased and remained increased during the follow-up period of 6 months.
Conclusion: LDKT is generally regarded as beneficial for allograft recipients and not particularly detrimental for the donors. However, it could be demonstrated in this study that a moderate reduction of kidney function by unilateral nephrectomy, resulted in an imbalance of components of vitamin A metabolism with a significant increase of retinol and RBP4 and apoRBP4 concentration in serum of donors.
Lipids in health and disease
10.1186/1476-511X-10-231
1476-511X
wos:2011-2013
231
WOS:000298740600001
Henze, A (reprint author), Univ Potsdam, Dept Physiol & Pathophysiol, Inst Nutr Sci, Nuthetal, Germany., henze@uni-potsdam.de
Andrea Henze
Jens Raila
Caroline Kempf
Petra Reinke
Anett Sefrin
Uwe Querfeld
Florian J. Schweigert
eng
uncontrolled
Donors
eng
uncontrolled
glomerular filtration rate
eng
uncontrolled
kidney transplantation
eng
uncontrolled
retinol
eng
uncontrolled
retinol-binding protein 4
eng
uncontrolled
transthyretin
Institut für Ernährungswissenschaft
Referiert
Open Access
40094
2017
2017
eng
7
postprint
1
--
2017-09-29
--
Vitamin A metabolism is changed in donors after living-kidney transplantation
Background
The kidneys are essential for the metabolism of vitamin A (retinol) and its transport proteins retinol-binding protein 4 (RBP4) and transthyretin. Little is known about changes in serum concentration after living donor kidney transplantation (LDKT) as a consequence of unilateral nephrectomy; although an association of these parameters with the risk of cardiovascular diseases and insulin resistance has been suggested. Therefore we analyzed the concentration of retinol, RBP4, apoRBP4 and transthyretin in serum of 20 living-kidney donors and respective recipients at baseline as well as 6 weeks and 6 months after LDKT.
Results
As a consequence of LDKT, the kidney function of recipients was improved while the kidney function of donors was moderately reduced within 6 weeks after LDKT. With regard to vitamin A metabolism, the recipients revealed higher levels of retinol, RBP4, transthyretin and apoRBP4 before LDKT in comparison to donors. After LDKT, the levels of all four parameters decreased in serum of the recipients, while retinol, RBP4 as well as apoRBP4 serum levels of donors increased and remained increased during the follow-up period of 6 months.
Conclusion
LDKT is generally regarded as beneficial for allograft recipients and not particularly detrimental for the donors. However, it could be demonstrated in this study that a moderate reduction of kidney function by unilateral nephrectomy, resulted in an imbalance of components of vitamin A metabolism with a significant increase of retinol and RBP4 and apoRBP4 concentration in serum of donors.
an observational study
urn:nbn:de:kobv:517-opus4-400942
online registration
Lipids in health and disease 10 (2011). - DOI: 10.1186/1476-511X-10-231
231
CC-BY - Namensnennung 4.0 International
Andrea Henze
Jens Raila
Caroline Kempf
Petra Reinke
Anett Sefrin
Uwe Querfeld
Florian J. Schweigert
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
373
eng
uncontrolled
Donors
eng
uncontrolled
glomerular filtration rate
eng
uncontrolled
kidney transplantation
eng
uncontrolled
retinol
eng
uncontrolled
retinol-binding protein 4
eng
uncontrolled
transthyretin
Biowissenschaften; Biologie
Medizin und Gesundheit
open_access
Institut für Ernährungswissenschaft
Referiert
Open Access
BioMed Central
Universität Potsdam
https://publishup.uni-potsdam.de/files/40094/pmnr373_online.pdf
36485
2011
2011
eng
4054
U583
8
12
26
article
Oxford Univ. Press
Oxford
German Diabetes & Dialysis Study I
1
--
--
--
Impact of vitamin A on clinical outcomes in haemodialysis patients
Background. Patients on maintenance haemodialysis treatment experience an excessive risk of cardiovascular disease and mortality. The vitamin A concentration is known to be higher in these patients compared to the general population where elevated vitamin A concentrations are associated with adverse outcome. The impact of vitamin A on morbidity and mortality in end-stage renal disease patients is controversial and is the topic of this study.
Methods. We analysed plasma retinol and retinol-binding protein 4 (RBP4) in 1177 diabetic haemodialysis patients, who participated in the German Diabetes and Dialysis Study (median follow-up 4 years). By Cox regression analyses hazard ratios (HRs) were determined for pre-specified, adjudicated end points according to baseline concentrations.
Results. Patients had a mean age of 66 +/- 8 years, mean retinol and RBP4 concentrations of 3.28 (0.71-7.44) and 4.02 (1.28-10.1) mu mol/L, respectively. Patients with retinol concentrations in the first quartile (<2.6 mu mol/L) had an almost 2-fold increased risk of all-cause mortality compared to patients of the fourth quartile [>3.9 mu mol/L; HR 1.81, 95% confidence interval (CI) 1.43-2.30]. There was a strong association between low retinol and the risk of sudden cardiac death (SCD, HR 2.22, 95% CI 1.41-3.50) and fatal infection (HR 2.19, 95% CI 1.26-3.82). Patients with RBP4 concentrations in the lowest quartile (<3.0 mu mol/L) were more likely to die of any cause (HR 1.43, 95% CI 1.14-1.80), experience SCD (HR 1.97, 95% CI 1.28-3.03) and cardiovascular events (HR 1.43, 95% CI 1.10-1.85).
Conclusion. This large cohort study shows a strong association of low retinol and RBP4 concentrations with SCD and all-cause mortality in diabetic haemodialysis patients.
Nephrology, dialysis, transplantation
10.1093/ndt/gfr171
0931-0509
wos:2011-2013
WOS:000297404000035
Espe, KM (reprint author), Univ Potsdam, Inst Nutr Sci, Potsdam, Germany., espe@uni-potsdam.de
Else-Kroner-Fresenius foundation
Katharina M. Espe
Jens Raila
Andrea Henze
Vera Krane
Florian J. Schweigert
Berthold Hocher
Christoph Wanner
Christiane Drechsler
eng
uncontrolled
haemodialysis
eng
uncontrolled
mortality
eng
uncontrolled
retinol
eng
uncontrolled
retinol-binding protein 4
eng
uncontrolled
sudden death
Institut für Ernährungswissenschaft
Referiert
36754
2011
2011
eng
936
945
10
4
42
article
SEAMEO
Bangkok
1
--
--
--
Association between Retinol-Binding protein and renal function among Asian subjects with type 2 diabetes mellitus a cross-sectionaö study
Retinol-binding protein 4 (RBP4) has been suggested as new adipokine, possibly linking obesity to type 2 diabetes mellitus (T2DM). Since the kidneys are the main site of RBP4 degradation and since renal failure is a frequent co-morbid condition with diabetes mellitus, we evaluated the association among RBP4, renal function and T2DM in an Asian population. RBP4 serum levels were analyzed in 110 subjects (50 with T2DM) using an enzyme-linked immunosorbent assay (ELISA). Based on a cut-off estimated glomerular filtration rate (eGFR) of 60 ml/min per 1.73 m(2) (calculated according the abbreviated MDRD formula which uses serum creatinine level, age and gender) and on the T2DM status, subjects were assigned to four subgroups: Group A - controls with an eGFR > 60 ml/min per 1.73 m(2), Group B - controls with an eGFR < 60 ml/min per 1.73 m(2), Group C- T2DM subjects with an eGFR>60 ml/min per 1.73 m(2), and Group D - T2DM subjects with an eGFR <60 ml/ mm per 1.73 m(2). In both the T2DM and control groups, RBP4 levels were higher in subjects with an eGFR < 60 ml/min per 1.73 m(2) than in subjects with an eGFR >60 ml/min per 1.73 m(2). However, the difference was only significant between the control groups (p <0.05). After adjusting for age, gender, BMI, eGFR and the presence of T2DM, eGFR, not T2DM, was associated with plasma RBP4 levels (p<0.05). These results suggest among Asians the eGFR, but not the presence of T2DM, is a major determinant of RBP4 serum levels. The eGFR should be taken into account when evaluating the role of RBP4 in the pathogenesis of insulin resistance and T2DM.
The Southeast Asian journal of tropical medicine and public health : official publication of the SEAMEO Regional Tropical Medicine and Public Health Project (TROPMED)
0125-1562
wos:2011-2013
WOS:000293434800020
Tungtrongchitr, R (reprint author), Mahidol Univ, Fac Trop Med, Dept Trop Nutr & Food Sci, 420-6 Ratchawithi Rd, Bangkok 10400, Thailand., tmrtg@mahidol.ac.th
Center for Biopharmaceutical Development and Innovative Therapy, Faculty
of Tropical Medicine; Mahidol University
Kittisak Thawnashom
Rungsunn Tungtrongchitr
Siriporn Chanchay
Anchalee Tungtrongchitr
Jens Raila
Andrea Henze
Florian J. Schweigert
eng
uncontrolled
retinol-binding protein 4
eng
uncontrolled
renal function
eng
uncontrolled
type 2 diabetes mellitus
eng
uncontrolled
Asian subjects
Institut für Ernährungswissenschaft
Referiert