7420
2014
2014
eng
1023
1033
11
postprint
1
2015-03-24
2014-03-20
--
In vitro toxicological characterisation of three arsenic-containing hydrocarbons
Arsenic-containing hydrocarbons are one group of fat-soluble organic arsenic compounds (arsenolipids) found in marine fish and other seafood. A risk assessment of arsenolipids is urgently needed, but has not been possible because of the total lack of toxicological data. In this study the cellular toxicity of three arsenic-containing hydrocarbons was investigated in cultured human bladder (UROtsa) and liver (HepG2) cells. Cytotoxicity of the arsenic-containing hydrocarbons was comparable to that of arsenite, which was applied as the toxic reference arsenical. A large cellular accumulation of arsenic, as measured by ICP-MS/MS, was observed after incubation of both cell lines with the arsenolipids. Moreover, the toxic mode of action shown by the three arsenic-containing hydrocarbons seemed to differ from that observed for arsenite. Evidence suggests that the high cytotoxic potential of the lipophilic arsenicals results from a decrease in the cellular energy level. This first in vitro based risk assessment cannot exclude a risk to human health related to the presence of arsenolipids in seafood, and indicates the urgent need for further toxicity studies in experimental animals to fully assess this possible risk.
urn:nbn:de:kobv:517-opus4-74201
online registration
Au-006607
Metallomics (2014) 6, S. 1023-1033. - DOI: 10.1039/c4mt00061g
<a href="http://publishup.uni-potsdam.de/opus4-ubp/frontdoor/index/index/docId/7418">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
Sören Meyer
M. Matissek
Sandra Marie Müller
M. S. Taleshi
Franziska Ebert
Kevin A. Francesconi
Tanja Schwerdtle
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
paper 170
eng
uncontrolled
cod-liver
eng
uncontrolled
human-cells
eng
uncontrolled
arsenolipids present
eng
uncontrolled
excision-repair
eng
uncontrolled
fatty-acids
eng
uncontrolled
marine oils
eng
uncontrolled
RP-HPLC
eng
uncontrolled
metabolites
eng
uncontrolled
identification
eng
uncontrolled
trivalent
Chemie und zugeordnete Wissenschaften
open_access
Institut für Chemie
Referiert
Open Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/7420/pmnr170.pdf
7418
2014
2014
eng
1023
1033
11
6
2014
article
1
--
2014-03-20
--
In vitro toxicological characterisation of three arsenic-containing hydrocarbons
Arsenic-containing hydrocarbons are one group of fat-soluble organic arsenic compounds (arsenolipids) found in marine fish and other seafood. A risk assessment of arsenolipids is urgently needed, but has not been possible because of the total lack of toxicological data. In this study the cellular toxicity of three arsenic-containing hydrocarbons was investigated in cultured human bladder (UROtsa) and liver (HepG2) cells. Cytotoxicity of the arsenic-containing hydrocarbons was comparable to that of arsenite, which was applied as the toxic reference arsenical. A large cellular accumulation of arsenic, as measured by ICP-MS/MS, was observed after incubation of both cell lines with the arsenolipids. Moreover, the toxic mode of action shown by the three arsenic-containing hydrocarbons seemed to differ from that observed for arsenite. Evidence suggests that the high cytotoxic potential of the lipophilic arsenicals results from a decrease in the cellular energy level. This first in vitro based risk assessment cannot exclude a risk to human health related to the presence of arsenolipids in seafood, and indicates the urgent need for further toxicity studies in experimental animals to fully assess this possible risk.
Metallomics
10.1039/c4mt00061g
1756-591X
1756-5901
online registration
Au-006607
<a href="http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-74201">Zweitveröffentlichung als Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe ; 170</a>
Sören Meyer
M. Matissek
Sandra Marie Müller
M. S. Taleshi
Franziska Ebert
Kevin A. Francesconi
Tanja Schwerdtle
eng
uncontrolled
cod-liver
eng
uncontrolled
human-cells
eng
uncontrolled
arsenolipids present
eng
uncontrolled
excision-repair
eng
uncontrolled
fatty-acids
eng
uncontrolled
marine oils
eng
uncontrolled
RP-HPLC
eng
uncontrolled
metabolites
eng
uncontrolled
identification
eng
uncontrolled
trivalent
Chemie und zugeordnete Wissenschaften
Institut für Chemie
Referiert
Open Access
RSC
Universität Potsdam