38015
2014
2014
eng
58
62
5
91
article
Elsevier
Amsterdam
1
--
--
--
Antimicrobial flavonoids and diterpenoids from Dodonaea angustifolia
South African journal of botany : an international interdisciplinary journal for botanical sciences
10.1016/j.sajb.2013.11.012
0254-6299
1727-9321
wos:2014
WOS:000333720900011
Omosa, LK (reprint author), Univ Nairobi, Dept Chem, Sch Phys Sci, POB 30197-00100, Nairobi, Kenya., lkerubo@uonbi.ac.ke
International Science Programme, Uppsala University, Sweden
[(ISP)-KEN-02]; National Commission for Science, Technology and
Innovation (NACOSTI), Kenya
Leonidah K. Omosa
Beatrice Amugune
Beth Ndunda
Trizah K. Milugo
Matthias Heydenreich
Abiy Yenesew
Jacob O. Midiwo
eng
uncontrolled
Dodonaea angustifolia
eng
uncontrolled
Surface exudates
eng
uncontrolled
Flavone
eng
uncontrolled
Flavanone
eng
uncontrolled
Diterpenoid
eng
uncontrolled
Antimicrobial activities
Institut für Chemie
Referiert
36793
2011
2011
eng
176
178
3
2
4
article
Elsevier
Amsterdam
1
--
--
--
Terpurinflavone an antiplasmodial flavone from the stem of Tephrosia Purpurea
The stem extract of Tephrosia purpurea showed antiplasmodial activity against the D6 (chloroquine-sensitive) and W2 (chloroquine-resistant) strains of Plasmodium falciparum with IC(50) values of 10.47 +/- 2.22 mu g/ml and 12.06 +/- 2.54 mu g/ml, respectively. A new prenylated flavone, named terpurinflavone, along with the known compounds lanceolatin A, (-)-semiglabrin and lanceolatin B have been isolated from this extract. The new compound, terpurinflavone, showed the highest antiplasmodial activity with IC(50) values of 3.12 +/- 0.28 mu M (D6) and 6.26 +/- 2.66 mu M (W2). The structures were determined on the basis of spectroscopic evidence.
Phytochemistry letters
10.1016/j.phytol.2011.02.010
1874-3900
wos:2011-2013
WOS:000290788100027
Yenesew, A (reprint author), Univ Nairobi, Dept Chem, POB 30197-00100, Nairobi, Kenya., ayenesew@uonbi.ac.ke
Deutche Forschungemeinschaft (DFG), Germany; Germany Federal Ministry
for Economic Cooperation and Development (BMZ) within the DFG/BMZ
Wanyama P. Juma
Hoseah M. Akala
Fredrick L. Eyase
Lois M. Muiva
Matthias Heydenreich
Faith A. Okalebo
Peter M. Gitu
Martin G. Peter
Douglas S. Walsh
Mabel Imbuga
Abiy Yenesew
eng
uncontrolled
Tephrosia purpurea
eng
uncontrolled
Leguminosae
eng
uncontrolled
Stem
eng
uncontrolled
Flavone
eng
uncontrolled
Terpurinflavone
eng
uncontrolled
Antiplasmodial
Institut für Chemie
Referiert