3225
2009
deu
postprint
0
2009-08-14
--
--
"Afghanistan kontrovers" und "Krieg verantwortungsbewusst beenden!"
"Afghanistan controversial" and "Ending the War responsible!"
Niels Annen (MdB) und Hans-Christian Ströbele (MdB) äußern sich in zwei Kommentaren zum Afghanistan-Einsatz der NATO.
0944-8101
urn:nbn:de:kobv:517-opus-34200
3420
WeltTrends - Zeitschrift für Internationale Politik, 68 (2009). - S. 26 - 29
<hr/>In Printform erschienen bei <a href="http://www.welttrends.de/"> WeltTrends e.V.</a>:<br/><br/>NATO in der Sinnkrise. - Potsdam : Welt-Trends, 2009. - 144 S. : Ill. - (Welttrends; 17.2009, 68)<br/>ISSN 0944-8101<br/>ISBN 978-3-86956-007-6<br/>--> <a href="http://www.welttrends.de/">bestellen</a>
Keine öffentliche Lizenz: Unter Urheberrechtsschutz
Niels Annen
Hans-Christian Ströbele
deu
uncontrolled
NATO
deu
uncontrolled
Afghanistan
deu
uncontrolled
Krieg
deu
uncontrolled
Kommentar
eng
uncontrolled
NATO
eng
uncontrolled
Afghanistan
eng
uncontrolled
War
eng
uncontrolled
Comment
Politikwissenschaft
NATO in der Sinnkrise 68 (2009)
WeltTrends e.V. Potsdam
Universität Potsdam
1036
1996
deu
postprint
0
2006-12-08
--
--
"Erzählen Sie keinen Unsinn, Genosse Ulbricht!" : Die VR Polen und die DDR in den 60er Jahren ; offizielle Harmonie und internes Mißtrauen
"Don’t say such foolish things, Comrade Ulbricht! : The PR Poland and the GDR in the 1960s ; public harmony and internal distrust
Gomułka’s harsh criticism of the Stalinist past and the introduction of liberal elements into the public life of Poland was not welcomed by the East German leadership. Ulbricht demanded full support for the sovereignty of the GDR and tried to prevent any independent Polish moves to come to terms with the Federal Republic. The Polish leadership strived towards a closer economic integration with the GDR and Czechoslovakia to foster industrial development in Poland and to bind the East German state more closely into the "socialist camp". These ideas were flatly rejected by the GDR. The level of economic interdependence between the two German states and the advantages of the GDR resulting from the "intra-German" status of trade and transfer of technologies provoked Gomułka’s distrust. Relations worsened even more when, towards the end of his time in power, Ulbricht moved towards a rapprochement with the FRG and showed some readiness to question the Görlitz treaty on the German-Polish border line.
urn:nbn:de:kobv:517-opus-11164
1116
WeltTrends : Zeitschrift für internationale Politik und vergleichende Studien. - 13 (1995). - S. 111 - 131
<hr>
erschienen in: WeltTrends : Zeitschrift für internationale Politik und vergleichende Studien. - 13 (1996)<br>
<a href="http://www.welttrends.de/">WeltTrends</a> erscheint im <a href="http://info.ub.uni-potsdam.de/cgi-bin/publika/view.pl?id=106">Universitätsverlag Potsdam</a><br>
Abowünsche und Bestellungen von Einzelheften bitte per Mail an den Universitätsverlag: <br>ubpub@rz.uni-potsdam.de<br>
Einzelheft: 5,00 €
<a href="http://www.uni-potsdam.de/db/wtcms/contenido-4.4.5/cms/front_content.php?idcat=25">(Preisliste)</a><br>
MA 8157
-
Mieczysław Tomala
Politikwissenschaft
open_access
Deutschland und Polen 13 (1996)
Extern
Universität Potsdam
https://publishup.uni-potsdam.de/files/1036/13_fb_tomala.pdf
3754
1990
deu
postprint
0
2009-12-08
--
--
"Geistige Mütterlichkeit" : Bildungstheorie oder strategischer Kampfbegriff gegen Männerdominanz im Mädchenschulwesen?
Inhalt: - Veröffentlichte Intimität und „sphärisches Gesetz" - Kulturtheorie als Bildungstheorie - Der Allgemeine deutsche Lehrerinnenverein (ADLV): weibliche Interessenvertretung als Kultur- und Bildungsauftrag
urn:nbn:de:kobv:517-opus-39277
3927
Die Deutsche Schule : DDS ; Zeitschrift für Erziehungswissenschaft, Bildungspolitik und pädagogische Praxis / hrsg. von der Gewerkschaft Erziehung und Wissenschaft. - Beiheft (1990), S. 209-224. - ISSN 0340-4099, 0012-0731
egger@...
Keine öffentliche Lizenz: Unter Urheberrechtsschutz
Juliane Jacobi
Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe
paper 133
Bildung und Erziehung
open_access
Department Erziehungswissenschaft
Institut für Erziehungswissenschaft
Universität Potsdam
https://publishup.uni-potsdam.de/files/3754/1990_Geistige_Muetterlichkeit.pdf
1056
1998
deu
postprint
0
2006-12-19
--
--
"In the National Interest" : Australiens Außenpolitik am Ende des 20. Jahrhunderts
In the National Interest : Australia’s foreign policy at the end of the 20th century
In August 1997 the Australian Government released the first White Paper ever issued on its foreign policy. As one important element, this essay tries to delineate the pro Asia-Pacific shift of Australia’s international economic and security orientations, particularly since the early 1970s - a foreign policy which could rest upon an certain bipartisan basis. The recently launched White Paper represents a new reflection upon Australia’s national interests and a soft relativisation of the strong emphasis on regional and multilateral foreign policy performances of former governments. According to a least the author’s judgement, the fundamental legacy of Australia’s international relations remain: a certain (a definite?) contradiction between the country’s predominant cultural and ethnic (!) heritage on the one hand and its geographical location on the other.
urn:nbn:de:kobv:517-opus-11383
1138
WeltTrends : Zeitschrift für internationale Politik und vergleichende Studien. - 19 (1998). - S. 121 – 137
<hr>
erschienen in: WeltTrends : Zeitschrift für internationale Politik und vergleichende Studien. - 19 (1998)<br>
<a href="http://www.welttrends.de/">WeltTrends</a> erscheint im <a href="http://info.ub.uni-potsdam.de/cgi-bin/publika/view.pl?id=106">Universitätsverlag Potsdam</a><br>
Abowünsche und Bestellungen von Einzelheften bitte per Mail an den Universitätsverlag: <br>ubpub@rz.uni-potsdam.de<br>
Einzelheft: 5,00 €
<a href="http://www.uni-potsdam.de/db/wtcms/contenido-4.4.5/cms/front_content.php?idcat=25">(Preisliste)</a><br>
MA 8157
-
Manfred Mols
Sozialwissenschaften
open_access
Deutsche und Tschechen 19 (1998)
Extern
Universität Potsdam
https://publishup.uni-potsdam.de/files/1056/19_fb_mols.pdf
42818
2017
2020
eng
1705
1738
36
959
postprint
1
2020-06-19
2020-06-19
--
"Lomonosov" satellite-space observatory to study extreme phenomena in space
The "Lomonosov" space project is lead by Lomonosov Moscow State University in collaboration with the following key partners: Joint Institute for Nuclear Research, Russia, University of California, Los Angeles (USA), University of Pueblo (Mexico), Sungkyunkwan University (Republic of Korea) and with Russian space industry organi-zations to study some of extreme phenomena in space related to astrophysics, astroparticle physics, space physics, and space biology. The primary goals of this experiment are to study:
-Ultra-high energy cosmic rays (UHECR) in the energy range of the Greizen-ZatsepinKuzmin (GZK) cutoff;
-Ultraviolet (UV) transient luminous events in the upper atmosphere;
-Multi-wavelength study of gamma-ray bursts in visible, UV, gamma, and X-rays;
-Energetic trapped and precipitated radiation (electrons and protons) at low-Earth orbit (LEO) in connection with global geomagnetic disturbances;
-Multicomponent radiation doses along the orbit of spacecraft under different geomagnetic conditions and testing of space segments of optical observations of space-debris and other space objects;
-Instrumental vestibular-sensor conflict of zero-gravity phenomena during space flight.
This paper is directed towards the general description of both scientific goals of the project and scientific equipment on board the satellite. The following papers of this issue are devoted to detailed descriptions of scientific instruments.
Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
10.25932/publishup-42818
urn:nbn:de:kobv:517-opus4-428185
1866-8372
online registration
Space Science Reviews 212 (2017) 1705–1738 DOI: 10.1007/s11214-017-0425-x
<a href="http://publishup.uni-potsdam.de/46237">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
CC-BY - Namensnennung 4.0 International
V. A. Sadovnichii
M. I. Panasyuk
A. M. Amelyushkin
V. V. Benghin
G. K. Garipov
V. V. Kalegaev
P. A. Klimov
B. A. Khrenov
V. L. Petrov
S. A. Sharakin
A. V. Shirokov
S. I. Svertilov
M. Y. Zotov
I. V. Yashin
E. S. Gorbovskoy
V. M. Lipunov
I. H. Park
J. Lee
S. Jeong
M. B. Kim
H. M. Jeong
Yuri Y. Shprits
V. Angelopoulos
C. T. Russell
A. Runov
D. Turner
R. J. Strangeway
R. Caron
S. Biktemerova
A. Grinyuk
M. Lavrova
L. Tkachev
A. Tkachenko
O. Martinez
H. Salazar
E. Ponce
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
959
eng
uncontrolled
gamma-ray bursts
eng
uncontrolled
ultra-high energy cosmic rays
eng
uncontrolled
radiation belts
eng
uncontrolled
space mission
Technik, Technologie
open_access
Mathematisch-Naturwissenschaftliche Fakultät
Referiert
Green Open-Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/42818/pmnr959.pdf
2505
2005
deu
postprint
0
2010-09-23
--
--
"More of the same" in der zweiten Amtszeit? : Die Außenpolitik des George W. Bush
More of the same? : The foreign policy of George W. Bush in the second term
Despite the difficult situation in Iraq, US President Bush easily won a second term, but his room for manoeuvre is now significantly smaller than it was four years ago. He has at least three conflicts on his plate: the first and most critical one in Iraq, the second the continuing war on terror and the third the struggle to consolidate Afghanistan. Conscious of the growing risk of US overstretch, Bush is now reaching out to the European allies. However, most observers anticipate a change in style rather than any real change in substance.
urn:nbn:de:kobv:517-opus-47625
4762
WeltTrends - Zeitschrift für Internationale Politik, 46 (2005), S. 109 - 123
<hr/>
In Printform erschienen bei <a href="http://www.welttrends.de/"> WeltTrends e.V.</a>:<br/><br/>
Globale Finanzmärkte. - Potsdam : Welt-Trends, 2005. - 208 S. - (Welttrends; 13.2005, 46)<br/>
ISSN 0944-8101<br/>
ISBN 3-937786-40-6<br/>
--> <a href="http://www.welttrends.de/index.php/start/zeitschrift/heft-46/">bestellen</a>
Keine öffentliche Lizenz: Unter Urheberrechtsschutz
Heinrich Kreft
deu
uncontrolled
USA
deu
uncontrolled
amerikanische Außenpolitik
deu
uncontrolled
internationaler Terrorismus
deu
uncontrolled
Afghanistan
eng
uncontrolled
USA
eng
uncontrolled
US foreign policy
eng
uncontrolled
international terrorism
eng
uncontrolled
Afghanistan
Politikwissenschaft
Globale Finanzmärkte 46 (2005)
WeltTrends e.V. Potsdam
Universität Potsdam
4108
1986
deu
postprint
0
2010-06-03
--
--
"Nebeneinander-her-reden" : Struktur und Entwicklung eines Verständigungsproblems
Inhalt: 1. Einleitung 2. Analyse- und Beschreibungskategorien 3. Das zu analysierende Gespräch: "Beglaubigungen hinten drauf?" 4. Unterschiedliche Kategorisierung des Problems: Erwartungsproblem versus Sachverhaltsproblem 5. Fazit
urn:nbn:de:kobv:517-opus-43169
4316
Grazer linguistische Studien : GLS 26 (1986), S. 131-150
egger@...
Keine öffentliche Lizenz: Unter Urheberrechtsschutz
Margret Selting
Zweitveröffentlichungen der Universität Potsdam : Philosophische Reihe
65
Sprache
open_access
Institut für Germanistik
Universität Potsdam
https://publishup.uni-potsdam.de/files/4108/nebeneinander.pdf
41476
2015
2019
eng
28
157
postprint
1
2019-02-12
2019-02-12
--
"This migrants' babble is not a German dialect!"
This article investigates a public debate in Germany that put a special spotlight on the interaction of standard language ideologies with social dichotomies, centering on the question of whether Kiezdeutsch, a new way of speaking in multilingual urban neighbourhoods, is a legitimate German dialect. Based on a corpus of emails and postings to media websites, I analyse central topoi in this debate and an underlying narrative on language and identity. Central elements of this narrative are claims of cultural elevation and cultural unity for an idealised standard language High German', a view of German dialects as part of a national folk culture, and the construction of an exclusive in-group of German' speakers who own this language and its dialects. The narrative provides a potent conceptual frame for the Othering of Kiezdeutsch and its speakers, and for the projection of social and sometimes racist deliminations onto the linguistic plane.
Postprints der Universität Potsdam : Philosopische Fakultät
the interaction of standard language ideology and 'us'/'them' dichotomies in the public discourse on a multiethnolect
10.25932/publishup-41476
urn:nbn:de:kobv:517-opus4-414764
1866-8380
online registration
Language in Society 44 (2015), pp. 341–368 DOI 10.1017/S0047404515000226
<a href="http://publishup.uni-potsdam.de/opus4-ubp/frontdoor/index/index/docId/38860">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
false
true
Keine öffentliche Lizenz: Unter Urheberrechtsschutz
Heike Wiese
Zweitveröffentlichungen der Universität Potsdam : Philosophische Reihe
157
eng
uncontrolled
standard language ideology
deu
uncontrolled
Kiezdeutsch
eng
uncontrolled
dialect
eng
uncontrolled
public discourse
eng
uncontrolled
othering
eng
uncontrolled
racism by proxy
Sprache
open_access
Philosophische Fakultät
Referiert
Open Access
Cambridge University Press (CUP)
Universität Potsdam
https://publishup.uni-potsdam.de/files/41476/ppr157.pdf
4826
1992
deu
postprint
0
2011-02-18
--
--
"Töchterfragen zur NS-Frauengeschichte" : eine Besprechung des Sammelbandes von L. Gravenhorst und C. Tatschmurat
urn:nbn:de:kobv:517-opus-50977
5097
Feministische Studien 20 (1992), 20, S. 141-145.
-
Keine öffentliche Lizenz: Unter Urheberrechtsschutz
Juliane Jacobi
Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe
paper 225
Bildung und Erziehung
open_access
Department Erziehungswissenschaft
Institut für Erziehungswissenschaft
Universität Potsdam
https://publishup.uni-potsdam.de/files/4826/toechterfragen_bearb.pdf
3756
1990
deu
postprint
0
2009-12-08
--
--
"Wer ist Sophie?"
Inhalt: I. Zur Geschlechterdifferenz in Rousseaus "Emile" II. Rousseau, der "autonome Mensch" III. Zum Geschlechterverhältnis IV. Emile, oder über die Erziehung des Mannes V. Ausblick: Gleichheit und Differenz
urn:nbn:de:kobv:517-opus-39286
3928
Pädagogische Rundschau. - 44 (1990), S. 303-319. - ISSN 0030-9273
egger@...
Keine öffentliche Lizenz: Unter Urheberrechtsschutz
Juliane Jacobi
Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe
paper 134
Bildung und Erziehung
open_access
Department Erziehungswissenschaft
Institut für Erziehungswissenschaft
Universität Potsdam
https://publishup.uni-potsdam.de/files/3756/1990_wer_ist_sophie.pdf
4575
2005
deu
postprint
0
2010-09-24
--
--
"Wie viel ist genug?" : Bevölkerungswachstum ; Forschungsgegenstand mit vielen Facetten
"How much is enough?" : Population growth ; object of research with many facets
„Menschen benötigen Platz zum Leben.“ In dieser Erkenntnis liegt noch nichts Besonderes oder gar Aufregendes. Erst die Tatsache, dass die menschliche Bevölkerung seit jeher zunimmt, aber der zur Verfügung stehende Platz konstant bleibt bzw. die Ressourcen in ihrem Bestand sogar abnehmen, macht dieses Thema wesentlich gehaltvoller. Offensichtlich ist außerdem: „Population growth seems to affect everything but is seldom held responsible for anything.“ (McKee 2003: 10) Dies ist der Hauptgrund dafür, dass gerade die Thematik der Bevölkerungsentwicklung internationale Beachtung und Aufmerksamkeit verdient.
urn:nbn:de:kobv:517-opus-47919
4791
WeltTrends - Zeitschrift für Internationale Politik, 47 (2005), S. 154 - 161
<hr/>
In Printform erschienen bei <a href="http://www.welttrends.de/"> WeltTrends e.V.</a>:<br/><br/>
Europäische Arbeitspolitik. - Potsdam : Welt-Trends, 2005. - 208 S. - (Welttrends; 13.2005, 47)<br/>
ISSN 0944-8101<br/>
ISBN 3-937786-41-4<br/>
--> <a href="http://www.welttrends.de/index.php/start/zeitschrift/heft-47/">bestellen</a>
Keine öffentliche Lizenz: Unter Urheberrechtsschutz
Markus Seyfried
deu
uncontrolled
Bevölkerungswachstum
deu
uncontrolled
Bevölkerungswissenschaft
deu
uncontrolled
Entwicklung
deu
uncontrolled
Weltbevölkerungsbericht
eng
uncontrolled
Population increase
eng
uncontrolled
population science
eng
uncontrolled
development
eng
uncontrolled
report of world population
Politikwissenschaft
Europäische Arbeitspolitik 47 (2005)
WeltTrends e.V. Potsdam
Universität Potsdam
915
2005
deu
postprint
0
2006-10-18
--
--
"Woher kommt eigentlich ...?" : Sprachberatung und Sprachgeschichte an der Universität Potsdam
urn:nbn:de:kobv:517-opus-9995
999
Ein gross und narhafft haffen : Festschrift für Joachim Gessinger / hrsg. Von Elisabeth Berner ; Manueal Böhm ; Anja Voeste. - Potsdam : Univ.-Verl., 2005. - 248 S.
Der Aufsatz ist erschienen in:<br><br>
Ein gross und narhafft haffen : Festschrift für Joachim Gessinger / hrsg. Von Elisabeth Berner ; Manueal Böhm ; Anja Voeste. - Potsdam : Univ.-Verl., 2005. - 248 S.<br>
ISBN 3-937786-35-X<br>
URN: <a href="http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:kobv:517-opus-5231"> urn:nbn:de:kobv:517-opus-5231</a>
<br><br>
Die Printausgabe kann beim <a href="http://info.ub.uni-potsdam.de/cgi-bin/publika/view.pl?id=201">Universitätsverlag Potsdam</a> bestellt werden.
GB 1825
-
Birgit Wolf-Bleiß
Germanische Sprachen; Deutsch
open_access
Institut für Germanistik
Universität Potsdam
https://publishup.uni-potsdam.de/files/915/wolf_bleiss.pdf
4827
1993
deu
postprint
0
2011-02-18
--
--
"Öffentliche" und "private" Erziehung aus der Sicht der pädagogisch-historischen Frauenforschung
Inhalt: 1. Zur Geschichte der Mädchenerziehung 2. Zur Geschichte des Lehrer- und Lehrerinnenberufes 3. Familienerziehung 4. Literatur
urn:nbn:de:kobv:517-opus-50986
5098
Bildung und Erziehung zwischen privater und öffentlicher Verantwortung / Dieter Timmermann (Hg.). - Bielefeld : Böllert, KT-Verl., 1993. - S. 39-52. ISBN 3-925515-29-1
-
Keine öffentliche Lizenz: Unter Urheberrechtsschutz
Juliane Jacobi
Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe
paper 226
Bildung und Erziehung
open_access
Department Erziehungswissenschaft
Institut für Erziehungswissenschaft
Universität Potsdam
https://publishup.uni-potsdam.de/files/4827/1993_oeffentliche_erziehung.pdf
9060
2010
2016
deu
23
99
postprint
1
2016-06-23
2016-06-23
--
'Gelegenheitsdichtung'
Der Beitrag dient als Einführung in einen Sammelband zu "Theorie und Praxis der Kasualdichtung in der Frühen Neuzeit". Er setzt sich kritisch mit dem Begriff der "Gelegenheitsdichtung" auseinander.
Postprints der Universität Potsdam : Philosophische Reihe
Probleme und Perspektiven der Forschung
urn:nbn:de:kobv:517-opus4-90608
1866-8380
online registration
<a href="https://publishup.uni-potsdam.de/opus4-ubp/frontdoor/index/index/docId/8918">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
Keine öffentliche Lizenz: Unter Urheberrechtsschutz
Volkhard Wels
Zweitveröffentlichungen der Universität Potsdam : Philosophische Reihe
99
deu
uncontrolled
Frühe Neuzeit
deu
uncontrolled
Deutsche Literatur der Frühen Neuzeit
deu
uncontrolled
Gelegenheitsdichtung
deu
uncontrolled
Kasualdichtung
deu
uncontrolled
Poetik
Literaturen germanischer Sprachen; Deutsche Literatur
open_access
Institut für Germanistik
Referiert
Open Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/9060/ppr99.pdf
52467
2020
eng
26
16
postprint
1
2020-04-08
--
--
(Non-)exhaustivity in focus partitioning across languages
We present novel experimental evidence on the availability and the status of exhaustivity inferences with focus partitioning in German, English, and Hungarian. Results suggest that German and English focus-background clefts and Hungarian focus share important properties, (É. Kiss 1998, 1999; Szabolcsi 1994; Percus 1997; Onea & Beaver 2009). Those constructions are anaphoric devices triggering an existence presupposition. EXH-inferences are not obligatory in such constructions in English, German, or Hungarian, against some previous literature (Percus 1997; Büring & Križ 2013; É. Kiss 1998), but in line with pragmatic analyses of EXH-inferences in clefts (Horn 1981, 2016; Pollard & Yasavul 2016). The cross-linguistic differences in the distribution of EXH-inferences are attributed to properties of the Hungarian number marking system.
Postprints der Universität Potsdam : Humanwissenschaftliche Reihe
urn:nbn:de:kobv:517-opus4-524677
1866-8364
10.25932/publishup-52467
<a href="http://publishup.uni-potsdam.de/52494">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
Veaugh-Geiss, Joseph & Tönnis, Swantje & Onea, Edgar. (2020). (Non-)exhaustivity in focus partitioning across languages. 10.1075/atoh.16.10zim
Version of record
CC-BY-NC-ND - Namensnennung, nicht kommerziell, keine Bearbeitungen 4.0 International
Malte Zimmermann
Joseph P. De Veaugh-Geiss
Swantje Tönnis
Edgar Onea
Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe
724
eng
uncontrolled
clefts
eng
uncontrolled
definite pseudoclefts
eng
uncontrolled
Hungarian focus
eng
uncontrolled
exhaustivity
eng
uncontrolled
experimental evidence
eng
uncontrolled
semantics-pragmatics interface
Linguistik
open_access
Referiert
Department Linguistik
Green Open-Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/52467/phr724.pdf
40324
2017
2017
eng
10
postprint
1
--
2017-12-14
--
1200 years of decadal-scale variability of Mediterranean vegetation and climate at Pantelleria Island, Italy
A new sedimentary sequence from Lago di Venere on Pantelleria Island, located in the Strait of Sicily between Tunisia and Sicily was recovered. The lake is located in the coastal infra-Mediterranean vegetation belt at 2 m a.s.l. Pollen, charcoal and sedimentological analyses are used to explore linkages among vegetation, fire and climate at a decadal scale over the past 1200 years. A dry period from ad 800 to 1000 that corresponds to the Medieval Warm Period' (WMP) is inferred from sedimentological analysis. The high content of carbonate recorded in this period suggests a dry phase, when the ratio of evaporation/precipitation was high. During this period the island was dominated by thermophilous and drought-tolerant taxa, such as Quercus ilex, Olea, Pistacia and Juniperus. A marked shift in the sediment properties is recorded at ad 1000, when carbonate content became very low suggesting wetter conditions until ad 1850-1900. Broadly, this period coincides with the Little Ice Age' (LIA), which was characterized by wetter and colder conditions in Europe. During this time rather mesic conifers (i.e. Pinus pinaster), shrubs and herbs (e.g. Erica arborea and Selaginella denticulata) expanded, whereas more drought-adapted species (e.g. Q. ilex) declined. Charcoal data suggest enhanced fire activity during the LIA probably as a consequence of anthropogenic burning and/or more flammable fuel (e.g. resinous Pinus biomass). The last century was characterized by a shift to high carbonate content, indicating a change towards drier conditions, and re-expansion of Q. ilex and Olea. The post-LIA warming is in agreement with historical documents and meteorological time series. Vegetation dynamics were co-determined by agricultural activities on the island. Anthropogenic indicators (e.g. Cerealia-type, Sporormiella) reveal the importance of crops and grazing on the island. Our pollen data suggest that extensive logging caused the local extinction of deciduous Quercus pubescens around ad1750.
urn:nbn:de:kobv:517-opus4-403240
online registration
The holocene 23 (2017) Nr. 10, S. 1477– 1486. - DOI: 10.1177/0959683613493935
Keine öffentliche Lizenz: Unter Urheberrechtsschutz
Camilla Calò
Paul D. Henne
Patricia Eugster
Jacqueline van Leeuwen
Adrian Gilli
Yvonne Hamann
Tommaso La Mantia
Salvatore Pasta
Elisa Vescovi
Willy Tinner
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
411
eng
uncontrolled
central Mediterranean
eng
uncontrolled
fire history
eng
uncontrolled
"Little Ice Age' (LIA)
eng
uncontrolled
"Medieval Warm Period' (MWP)
lat
uncontrolled
Pinus pinaster
lat
uncontrolled
Quercus ilex
lat
uncontrolled
Quercus pubescens
eng
uncontrolled
vegetation history
Geowissenschaften
open_access
Institut für Geowissenschaften
Referiert
Sage
Institut für Erd- und Umweltwissenschaften
Universität Potsdam
https://publishup.uni-potsdam.de/files/40324/pmnr411_online.pdf
887
2005
deu
postprint
0
2006-10-10
--
--
1945 und die Polen
Poland and the year 1945
The current series of anniversaries concerning World War II raise the question of how Poland is coming to terms with its past. The article summarises the ongoing Polish debate about the Warsaw Uprising and the changing perspectives on Polish history in society and political circles. The discussion about Poland’s view on its own past has great influence on recent foreign political relations, e.g. with Germany, the Ukraine, or Russia.
urn:nbn:de:kobv:517-opus-9747
974
WeltTrends - Zeitschrift für Internationale Politik, 47 (2005), S. 127 - 139
<hr/>
In Printform erschienen bei <a href="http://www.welttrends.de/"> WeltTrends e.V.</a>:<br/><br/>
Europäische Arbeitspolitik. - Potsdam : Welt-Trends, 2005. - 208 S. - (Welttrends; 13.2005, 47)<br/>
ISSN 0944-8101<br/>
ISBN 3-937786-41-4<br/>
--> <a href="http://www.welttrends.de/index.php/start/zeitschrift/heft-47/">bestellen</a>
MA 8157
Piotr Buras
deu
uncontrolled
Polen
deu
uncontrolled
Deutschland
deu
uncontrolled
2. Weltkrieg
eng
uncontrolled
Poland
eng
uncontrolled
Germany
eng
uncontrolled
World War II
Politikwissenschaft
open_access
Europäische Arbeitspolitik 47 (2005)
WeltTrends e.V. Potsdam
Universität Potsdam
https://publishup.uni-potsdam.de/files/887/47_fb_buras.pdf
52566
2020
2020
eng
12
7
postprint
1
2020-07-07
2020-03-20
--
25.1% high-efficiency monolithic perovskite silicon tandem solar cell with a high bandgap perovskite absorber
Monolithic perovskite silicon tandem solar cells can overcome the theoretical efficiency limit of silicon solar cells. This requires an optimum bandgap, high quantum efficiency, and high stability of the perovskite. Herein, a silicon heterojunction bottom cell is combined with a perovskite top cell, with an optimum bandgap of 1.68 eV in planar p-i-n tandem configuration. A methylammonium-free FA(0.75)Cs(0.25)Pb(I0.8Br0.2)(3) perovskite with high Cs content is investigated for improved stability. A 10% molarity increase to 1.1 m of the perovskite precursor solution results in approximate to 75 nm thicker absorber layers and 0.7 mA cm(-2) higher short-circuit current density. With the optimized absorber, tandem devices reach a high fill factor of 80% and up to 25.1% certified efficiency. The unencapsulated tandem device shows an efficiency improvement of 2.3% (absolute) over 5 months, showing the robustness of the absorber against degradation. Moreover, a photoluminescence quantum yield analysis reveals that with adapted charge transport materials and surface passivation, along with improved antireflection measures, the high bandgap perovskite absorber has the potential for 30% tandem efficiency in the near future.
Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
urn:nbn:de:kobv:517-opus4-525668
1866-8372
10.25932/publishup-52566
<a href="http://publishup.uni-potsdam.de/52578">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
2000152
Sol. RRL, 4: 2000152. https://doi.org/10.1002/solr.202000152
Version of record
CC-BY-NC-ND - Namensnennung, nicht kommerziell, keine Bearbeitungen 4.0 International
Patricia S. C. Schulze
Alexander J. Bett
Martin Bivour
Pietro Caprioglio
Fabian M. Gerspacher
Özde Ş. Kabaklı
Armin Richter
Martin Stolterfoht
Qinxin Zhang
Dieter Neher
Martin Hermle
Harald Hillebrecht
Stefan W. Glunz
Jan Christoph Goldschmidt
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
1197
eng
uncontrolled
heterojunction silicon solar cells
eng
uncontrolled
interfaces
eng
uncontrolled
perovskite solar cells
eng
uncontrolled
tandem solar cells
eng
uncontrolled
thin films
Physik
open_access
Institut für Physik und Astronomie
Referiert
Green Open-Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/52566/pmnr1197.pdf
43466
2019
2019
eng
785
807
23
737
postprint
1
2019-09-11
2019-09-11
--
3-D crustal density model of the Sea of Marmara
Abstract. The Sea of Marmara, in northwestern Turkey, is a transition zone where the dextral North Anatolian Fault zone (NAFZ) propagates westward from the Anatolian Plate to the Aegean Sea Plate. The area is of interest in the context of seismic hazard of Istanbul, a metropolitan area with about 15 million inhabitants. Geophysical observations indicate that the crust is heterogeneous beneath the Marmara basin, but a detailed characterization of the crustal heterogeneities is still missing. To assess if and how crustal heterogeneities are related to the NAFZ segmentation below the Sea of Marmara, we develop new crustal-scale 3-D density models which integrate geological and seismological data and that are additionally constrained by 3-D gravity modeling. For the latter, we use two different gravity datasets including global satellite data and local marine gravity observation. Considering the two different datasets and the general non-uniqueness in potential field modeling, we suggest three possible “end-member” solutions that are all consistent with the observed gravity field and illustrate the spectrum of possible solutions. These models indicate that the observed gravitational anomalies originate from significant density heterogeneities within the crust. Two layers of sediments, one syn-kinematic and one pre-kinematic with respect to the Sea of Marmara formation are underlain by a heterogeneous crystalline crust. A felsic upper crystalline crust (average density of 2720 kgm⁻³) and an intermediate to mafic lower crystalline crust (average density of 2890 kgm⁻³) appear to be cross-cut by two large, dome-shaped mafic highdensity bodies (density of 2890 to 3150 kgm⁻³) of considerable thickness above a rather uniform lithospheric mantle (3300 kgm⁻³). The spatial correlation between two major bends of the main Marmara fault and the location of the highdensity bodies suggests that the distribution of lithological heterogeneities within the crust controls the rheological behavior along the NAFZ and, consequently, maybe influences fault segmentation and thus the seismic hazard assessment in the region.
Postprints der Universität Potsdam Mathematisch-Naturwissenschaftliche Reihe
10.25932/publishup-43466
urn:nbn:de:kobv:517-opus4-434661
1866-8372
Solid Earth 10 (2019) S. 785–807 DOI: 10.5194/se-10-785-2019
<a href="http://publishup.uni-potsdam.de/opus4-ubp/frontdoor/index/index/docId/43465">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
CC-BY - Namensnennung 4.0 International
Ershad Gholamrezaie
Magdalena Scheck-Wenderoth
Judith Bott
Oliver Heidbach
Manfred Strecker
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
737
eng
uncontrolled
North Anatolian Fault
eng
uncontrolled
Shear Zone
eng
uncontrolled
Northwestern Anatolia
eng
uncontrolled
Geomechanical Model
eng
uncontrolled
Tectonic Evolution
eng
uncontrolled
Slip Distribution
eng
uncontrolled
Middle Strand
eng
uncontrolled
Pull-Apart
eng
uncontrolled
Long-Term
eng
uncontrolled
NW Turkey
Geowissenschaften
open_access
Institut für Geowissenschaften
Referiert
Open Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/43466/pmnr737.pdf
3234
2009
deu
postprint
0
2009-08-14
--
--
60 Jahre NATO : zwischen Irrelevanz und Überforderung
60 Years NATO : between irrelevance and excessive demands
Welchen Aufgaben soll sich die NATO zuwenden? Wo soll sie enden? Als klassisches Militärbündnis verliert sie jedenfalls an Bedeutung. Die gegenwärtige Krise der regionalen Allianz mit globaler Reichweite muss genutzt werden für eine strategische Neuausrichtung der Struktur und Funktion des Bündnisses. Die Rolle der NATO als Werkzeug für multinationale Interventionen entscheidet über die Bildung globaler Koalitionen.
0944-8101
urn:nbn:de:kobv:517-opus-34115
3411
WeltTrends - Zeitschrift für Internationale Politik, 68 (2009). - S. 77 - 87
<hr/>In Printform erschienen bei <a href="http://www.welttrends.de/"> WeltTrends e.V.</a>:<br/><br/>NATO in der Sinnkrise. - Potsdam : Welt-Trends, 2009. - 144 S. : Ill. - (Welttrends; 17.2009, 68)<br/>ISSN 0944-8101<br/>ISBN 978-3-86956-007-6<br/>--> <a href="http://www.welttrends.de/">bestellen</a>
Keine öffentliche Lizenz: Unter Urheberrechtsschutz
Rolf Mützenich
deu
uncontrolled
NATO
deu
uncontrolled
Sicherheitspolitik
deu
uncontrolled
Internationale Organisationen
eng
uncontrolled
NATO
eng
uncontrolled
Security Policy
eng
uncontrolled
International Organizations
Politikwissenschaft
NATO in der Sinnkrise 68 (2009)
WeltTrends e.V. Potsdam
Universität Potsdam
4113
1994
deu
postprint
0
2010-06-04
--
--
[Bericht der] Sektion Textlinguistik und Stilistik : Schwerpunkt 'Sprech- und Gesprächsstile'; Beitrag im Rahmen der 24. Jahrestagung der Gesellschaft für Angewandte Linguistik GAL e.V.
urn:nbn:de:kobv:517-opus-43010
4301
Fachkommunikation : Kongreßbeiträge zur 24. Jahrestagung der Gesellschaft für Angewandte Linguistik GAL e.V. / hrsg. von Bernd Spillner. - Frankfurt am Main [u.a.] : Lang, 1994. - S. 165-168
Keine öffentliche Lizenz: Unter Urheberrechtsschutz
Margret Selting
Barbara Sandig
Zweitveröffentlichungen der Universität Potsdam : Philosophische Reihe
68
Sprache
open_access
Institut für Germanistik
Universität Potsdam
https://publishup.uni-potsdam.de/files/4113/Fachkom_24.pdf
4114
1995
deu
postprint
0
2010-06-04
--
--
[Bericht zur] Sektion Textlinguistik und Stilistik : Schwerpunkt 'Sprech- und Gesprächsstile'; Beitrag im Rahmen der 25. Jahrestagung der Gesellschaft für Angewandte Linguistik GAL e.V.
urn:nbn:de:kobv:517-opus-39259
3925
Fachkommunikation / [Gesellschaft für Angewandte Linguistik e. V.] Hrsg. von Bernd Spillner. - Tübingen : Narr, 1995. - S. 247-252
Keine öffentliche Lizenz: Unter Urheberrechtsschutz
Margret Selting
Barbara Sandig
Zweitveröffentlichungen der Universität Potsdam : Philosophische Reihe
69
Sprache
open_access
Institut für Germanistik
Universität Potsdam
https://publishup.uni-potsdam.de/files/4114/Fachkomm_25.pdf
40059
2017
2017
eng
5
postprint
1
--
2017-09-22
--
[µ2-O,O′,Oʺ,Oʺ′-Bis(1,2-dithiooxalato-S,S′)nickel(II)]bis[-O,O′-bis(1,2-dithiooxalato-S,S′)-nickel(II)pentaquaholmium(III)]hydrate, [Ho2Ni3(dto)6(H2O)10]
Planar bis(1,2-dithiooxalato)nickelate(II), [Ni(dto)]2− reacts in aqueous solutions with lanthanide ions (Ln3+) to form pentanuclear, hetero-bimetallic complexes of the general composition [{Ln(H2O)n}2{Ni(dto)2}3]·xH2O. (n = 4 or 5; x = 9–12). The complex [{Ho(H2O)5}2{Ni(dto)2}3]·10H2O, Ho2Ni3, was synthesized and characterized by single crystal X-ray structure analysis and powder diffraction. The Ho2Ni3 complex crystallizes as monoclinic crystals in the space group P21/c. The channels and cavities, appearing in the crystal packing of the complex molecules, are occupied by a varying amount of non-coordinated water molecules.
urn:nbn:de:kobv:517-opus4-400598
online registration
Molbank 2016 Nr. 2. - DOI: 10.3390/M895
M895
CC-BY - Namensnennung 4.0 International
Jana König
Alexandra Kelling
Uwe Schilde
Peter Strauch
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
360
eng
uncontrolled
lanthanides
eng
uncontrolled
holmium(III)
eng
uncontrolled
1,2-dithiooxalate
eng
uncontrolled
crystal structure
eng
uncontrolled
nickel(II)
Chemie und zugeordnete Wissenschaften
open_access
Institut für Chemie
Referiert
Open Access
Multidisciplinary Digital Publishing Institute (MDPI)
Universität Potsdam
https://publishup.uni-potsdam.de/files/40059/pmnr360_online.pdf
42710
2013
2020
eng
15
604
postprint
1
2020-03-04
2020-03-04
--
A best practice fall prevention exercise program to improve balance, strength/power, and psychosocial health in older adults
Background: With increasing age neuromuscular deficits (e.g., sarcopenia) may result in impaired physical performance and an increased risk for falls. Prominent intrinsic fall-risk factors are age-related decreases in balance and strength / power performance as well as cognitive decline. Additional studies are needed to develop specifically tailored exercise programs for older adults that can easily be implemented into clinical practice. Thus, the objective of the present trial is to assess the effects of a fall prevention program that was developed by an interdisciplinary expert panel on measures of balance, strength / power, body composition, cognition, psychosocial well-being, and falls self-efficacy in healthy older adults. Additionally, the time-related effects of detraining are tested.
Methods/Design: Healthy old people (n = 54) between the age of 65 to 80 years will participate in this trial. The testing protocol comprises tests for the assessment of static / dynamic steady-state balance (i.e., Sharpened Romberg Test, instrumented gait analysis), proactive balance (i.e., Functional Reach Test; Timed Up and Go Test), reactive balance (i.e., perturbation test during bipedal stance; Push and Release Test), strength (i.e., hand grip strength test; Chair Stand Test), and power (i.e., Stair Climb Power Test; countermovement jump). Further, body composition will be analysed using a bioelectrical impedance analysis system. In addition, questionnaires for the assessment of psychosocial (i.e., World Health Organisation Quality of Life Assessment-Bref), cognitive (i.e., Mini Mental State Examination), and fall risk determinants (i.e., Fall Efficacy Scale -International) will be included in the study protocol. Participants will be randomized into two intervention groups or the control / waiting group. After baseline measures, participants in the intervention groups will conduct a 12-week balance and strength / power exercise intervention 3 times per week, with each training session lasting 30 min. (actual training time). One intervention group will complete an extensive supervised training program, while the other intervention group will complete a short version (` 3 times 3') that is home-based and controlled by weekly phone calls. Post-tests will be conducted right after the intervention period. Additionally, detraining effects will be measured 12 weeks after program cessation. The control group / waiting group will not participate in any specific intervention during the experimental period, but will receive the extensive supervised program after the experimental period.
Discussion: It is expected that particularly the supervised combination of balance and strength / power training will improve performance in variables of balance, strength / power, body composition, cognitive function, psychosocial well-being, and falls self-efficacy of older adults. In addition, information regarding fall risk assessment, dose-response-relations, detraining effects, and supervision of training will be provided. Further, training-induced health-relevant changes, such as improved performance in activities of daily living, cognitive function, and quality of life, as well as a reduced risk for falls may help to lower costs in the health care system. Finally, practitioners, therapists, and instructors will be provided with a scientifically evaluated feasible, safe, and easy-to-administer exercise program for fall prevention.
Postprints der Universität Potsdam : Humanwissenschaftliche Reihe
study protocol for a randomized controlled trial
10.25932/publishup-42710
urn:nbn:de:kobv:517-opus4-427104
1866-8364
BMC Geriatrics 13 (2013) 105 DOI: 10.1186/1471-2318-13-105
<a href="http://publishup.uni-potsdam.de/34662">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
105
Yves J. Gschwind
Reto W. Kressig
Andre Lacroix
Thomas Mühlbauer
Barbara Pfenninger
Urs Granacher
eng
uncontrolled
seniors
eng
uncontrolled
fall risk assessment
eng
uncontrolled
resistance training
eng
uncontrolled
postural stability
Medizin und Gesundheit
open_access
Mathematisch-Naturwissenschaftliche Fakultät
Referiert
Open Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/42710/phr604.pdf
44509
2020
2020
eng
26
823
postprint
1
2020-02-26
2020-02-26
--
A Biostimulant Obtained from the Seaweed Ascophyllum nodosum Protects Arabidopsis thaliana from Severe Oxidative Stress
Abiotic stresses cause oxidative damage in plants. Here, we demonstrate that foliar application of an extract from the seaweed Ascophyllum nodosum, SuperFifty (SF), largely prevents paraquat (PQ)-induced oxidative stress in Arabidopsis thaliana. While PQ-stressed plants develop necrotic lesions, plants pre-treated with SF (i.e., primed plants) were unaffected by PQ. Transcriptome analysis revealed induction of reactive oxygen species (ROS) marker genes, genes involved in ROS-induced programmed cell death, and autophagy-related genes after PQ treatment. These changes did not occur in PQ-stressed plants primed with SF. In contrast, upregulation of several carbohydrate metabolism genes, growth, and hormone signaling as well as antioxidant-related genes were specific to SF-primed plants. Metabolomic analyses revealed accumulation of the stress-protective metabolite maltose and the tricarboxylic acid cycle intermediates fumarate and malate in SF-primed plants. Lipidome analysis indicated that those lipids associated with oxidative stress-induced cell death and chloroplast degradation, such as triacylglycerols (TAGs), declined upon SF priming. Our study demonstrated that SF confers tolerance to PQ-induced oxidative stress in A. thaliana, an effect achieved by modulating a range of processes at the transcriptomic, metabolic, and lipid levels.
Postprints der Universität Potsdam : Mathematisch Naturwissenschaftliche Reihe
10.25932/publishup-44509
urn:nbn:de:kobv:517-opus4-445093
1866-8372
International Journal of Molecular Sciences 21 (2020) 2 Art. 474 DOI: 10.3390/ijms21020474
<a href="http://publishup.uni-potsdam.de/44508">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
474
CC-BY - Namensnennung 4.0 International
Mohammad Amin Omidbakhshfard
Sujeeth Neerakkal
Saurabh Gupta
Nooshin Omranian
Kieran J. Guinan
Yariv Brotman
Zoran Nikoloski
Alisdair R. Fernie
Bernd Mueller-Roeber
Tsanko S. Gechev
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
823
eng
uncontrolled
Ascophyllum nodosum
eng
uncontrolled
Arabidopsis thaliana
eng
uncontrolled
biostimulant
eng
uncontrolled
paraquat
eng
uncontrolled
priming
eng
uncontrolled
oxidative stress tolerance
eng
uncontrolled
reactive oxygen species
Chemie und zugeordnete Wissenschaften
Biowissenschaften; Biologie
open_access
Mathematisch-Naturwissenschaftliche Fakultät
Referiert
Open Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/44509/pmnr823.pdf
41293
2018
2018
eng
24
postprint
1
2018-07-13
2018-07-13
--
A blueprint for successful peacekeeping?
On 6 June 1982, Israel invaded Lebanon to fight the Palestinian
Liberation Organization (PLO). Between August 1982 and February
1984, the US, France, Britain and Italy deployed a Multinational
Force (MNF) to Beirut. Its task was to act as an interposition force to
bolster the government and to bring peace to the people. The
mission is often forgotten or merely remembered in context with
the bombing of US Marines’ barracks. However, an analysis of the
Italian contingent shows that the MNF was not doomed to fail and
could accomplish its task when operational and diplomatic efforts
were coordinated. The Italian commander in Beirut, General Franco
Angioni, followed a successful approach that sustained neutrality,
respectful behaviour and minimal force, which resulted in a
qualified success of the Italian efforts.
The International History Review
the Italians in Beirut (Lebanon), 1982–1984
urn:nbn:de:kobv:517-opus4-412937
online registration
The International History Review (2018) S. 1–23 DOI: 10.1080/07075332.2018.1431804
CC-BY-NC-ND - Namensnennung, nicht kommerziell, keine Bearbeitungen 4.0 International
Bastian Matteo Scianna
Zweitveröffentlichungen der Universität Potsdam : Philosophische Reihe
143
eng
uncontrolled
peacekeeping
eng
uncontrolled
Italy
eng
uncontrolled
Lebanon
eng
uncontrolled
Middle East
eng
uncontrolled
Beirut
Geschichte und Geografie
open_access
Philosophische Fakultät
Referiert
Open Access
Taylor & Francis Open Access Agreement
Universität Potsdam
https://publishup.uni-potsdam.de/files/41293/ppr143.online.pdf
52582
2020
eng
17
1
postprint
1
2020-09-03
--
--
A Body Shape Index (ABSI) achieves better mortality risk stratification than alternative indices of abdominal obesity: results from a large European cohort
Abdominal and general adiposity are independently associated with mortality, but there is no consensus on how best to assess abdominal adiposity. We compared the ability of alternative waist indices to complement body mass index (BMI) when assessing all-cause mortality. We used data from 352,985 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC) and Cox proportional hazards models adjusted for other risk factors. During a mean follow-up of 16.1 years, 38,178 participants died. Combining in one model BMI and a strongly correlated waist index altered the association patterns with mortality, to a predominantly negative association for BMI and a stronger positive association for the waist index, while combining BMI with the uncorrelated A Body Shape Index (ABSI) preserved the association patterns. Sex-specific cohort-wide quartiles of waist indices correlated with BMI could not separate high-risk from low-risk individuals within underweight (BMI<18.5 kg/m(2)) or obese (BMI30 kg/m(2)) categories, while the highest quartile of ABSI separated 18-39% of the individuals within each BMI category, which had 22-55% higher risk of death. In conclusion, only a waist index independent of BMI by design, such as ABSI, complements BMI and enables efficient risk stratification, which could facilitate personalisation of screening, treatment and monitoring.
Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
urn:nbn:de:kobv:517-opus4-525827
1866-8372
10.25932/publishup-52582
<a href="http://publishup.uni-potsdam.de/52584">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
14541
Sci Rep 10, 14541 (2020). https://doi.org/10.1038/s41598-020-71302-5
Version of record
CC-BY - Namensnennung 4.0 International
Sofa Christakoudi
Konstantinos K. Tsilidis
David C. Muller
Heinz Freisling
Elisabete Weiderpass
Kim Overvad
Stefan Söderberg
Christel Häggström
Tobias Pischon
Christina C. Dahm
Jie Zhang
Anne Tjønneland
Matthias Bernd Schulze
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
1200
eng
uncontrolled
all-cause mortality
eng
uncontrolled
anthropometric measures
eng
uncontrolled
mass index
eng
uncontrolled
overweight
eng
uncontrolled
cancer
eng
uncontrolled
prediction
eng
uncontrolled
adiposity
eng
uncontrolled
size
Biowissenschaften; Biologie
open_access
Institut für Ernährungswissenschaft
Referiert
Green Open-Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/52582/pmnr1200.pdf
39748
2016
2017
eng
26
121
postprint
1
2017-07-14
2017-07-14
--
A cognitive-constructionist approach to Spanish creo Ø and creo yo ‘[I] think’
The present study approaches the Spanish postposed constructions creo Ø and creo yo ‘[p], [I] think’ from a cognitive-constructionist perspective. It is argued that both constructions are to be distinguished from one another because creo Ø has a subjective function, while in creo yo, it is the intersubjective dimension that is particularly prominent. The present investigation takes both a qualitative and a quantitative perspective. With regard to the latter, the problem of quantitative representativity is addressed. The discussion posed the question of how empirical research can feed back into theory, more precisely, into the framework of Cognitive Construction Grammar. The data to be analyzed here are retrieved from the corpora Corpus de Referencia del Español Actual and Corpus del Español.
Postprints der Universität Potsdam : Philosophische Reihe
urn:nbn:de:kobv:517-opus4-397485
1866-8380
online registration
Folia Linguistica 50 (2016) 2, S. 449-474. DOI 10.1515/flin-2016-0017
Keine öffentliche Lizenz: Unter Urheberrechtsschutz
Anja Hennemann
Zweitveröffentlichungen der Universität Potsdam : Philosophische Reihe
121
eng
uncontrolled
Cognitive Construction Grammar
eng
uncontrolled
parenthetic verbs
eng
uncontrolled
Spanish
eng
uncontrolled
corpus analysis
eng
uncontrolled
quantitativity/qualitativity
Sprache
open_access
Institut für Romanistik
Referiert
Open Access
Walter de Gruyter Online Zeitschriften
Universität Potsdam
https://publishup.uni-potsdam.de/files/39748/ppr221_online.pdf
9949
2014
eng
11
postprint
1
--
2014-11-14
--
A compact multifunctional microfluidic platform for exploring cellular dynamics in real-time using electrochemical detection
Downscaling of microfluidic cell culture and detection devices for electrochemical monitoring has mostly focused on miniaturization of the microfluidic chips which are often designed for specific applications and therefore lack functional flexibility. We present a compact microfluidic cell culture and electrochemical analysis platform with in-built fluid handling and detection, enabling complete cell based assays comprising on-line electrode cleaning, sterilization, surface functionalization, cell seeding, cultivation and electrochemical real-time monitoring of cellular dynamics. To demonstrate the versatility and multifunctionality of the platform, we explored amperometric monitoring of intracellular redox activity in yeast (Saccharomyces cerevisiae) and detection of exocytotically released dopamine from rat pheochromocytoma cells (PC12). Electrochemical impedance spectroscopy was used in both applications for monitoring cell sedimentation and adhesion as well as proliferation in the case of PC12 cells. The influence of flow rate on the signal amplitude in the detection of redox metabolism as well as the effect of mechanical stimulation on dopamine release were demonstrated using the programmable fluid handling capability. The here presented platform is aimed at applications utilizing cell based assays, ranging from e.g. monitoring of drug effects in pharmacological studies, characterization of neural stem cell differentiation, and screening of genetically modified microorganisms to environmental monitoring.
urn:nbn:de:kobv:517-opus4-99492
online registration
Keine öffentliche Lizenz: Unter Urheberrechtsschutz
K. Zór
A. Heiskanen
Claudia Caviglia
M. Vergani
E. Landini
F. Shah
Marco Carminati
A. Martínez-Serrano
T. Ramos Moreno
M. Kokaia
Dafna Benayahu
Zs. Keresztes
D. Papkovsky
Ursula Wollenberger
W. E. Svendsen
M. Dimaki
G. Ferrari
R. Raiteri
M. Sampietro
M. Dufva
J. Emnéus
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
289
Chemie und zugeordnete Wissenschaften
open_access
Institut für Biochemie und Biologie
Referiert
Open Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/9949/pmnr289_online.pdf
41351
2018
2018
eng
458
postprint
1
2018-07-13
2018-07-13
--
A comparative study of photoinduced deformation in azobenzene containing polymer films
In this paper two groups supporting different views on the mechanism of light induced polymer deformation argue about the respective underlying theoretical conceptions, in order to bring this interesting debate to the attention of the scientific community. The group of Prof. Nicolae Hurduc supports the model claiming that the cyclic isomerization of azobenzenes may cause an athermal transition of the glassy azobenzene containing polymer into a fluid state, the so-called photo-fluidization concept. This concept is quite convenient for an intuitive understanding of the deformation process as an anisotropic flow of the polymer material. The group of Prof. Svetlana Santer supports the re-orientational model where the mass-transport of the polymer material accomplished during polymer deformation is stated to be generated by the light-induced re-orientation of the azobenzene side chains and as a consequence of the polymer backbone that in turn results in local mechanical stress, which is enough to irreversibly deform an azobenzene containing material even in the glassy state. For the debate we chose three polymers differing in the glass transition temperature, 32 °C, 87 °C and 95 °C, representing extreme cases of flexible and rigid materials. Polymer film deformation occurring during irradiation with different interference patterns is recorded using a homemade set-up combining an optical part for the generation of interference patterns and an atomic force microscope for acquiring the kinetics of film deformation. We also demonstrated the unique behaviour of azobenzene containing polymeric films to switch the topography in situ and reversibly by changing the irradiation conditions. We discuss the results of reversible deformation of three polymers induced by irradiation with intensity (IIP) and polarization (PIP) interference patterns, and the light of homogeneous intensity in terms of two approaches: the re-orientational and the photo-fluidization concepts. Both agree in that the formation of opto-mechanically induced stresses is a necessary prerequisite for the process of deformation. Using this argument, the deformation process can be characterized either as a flow or mass transport.
Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
1866-8372
urn:nbn:de:kobv:517-opus4-413510
online registration
Soft Matter (2016) 12, 2593-2603. - DOI: 10.1039/C6SM00029K
Keine öffentliche Lizenz: Unter Urheberrechtsschutz
Nataraja Sekhar Yadavalli
Sarah Loebner
Thomas Papke
Elena Sava
Nicolae Hurduc
Svetlana A. Santer
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
458
eng
uncontrolled
light-induced deformation
eng
uncontrolled
surface-relief gratings
eng
uncontrolled
optical near-field
eng
uncontrolled
chromophore orientations
eng
uncontrolled
atomic-force; nano-objects
eng
uncontrolled
brushes
eng
uncontrolled
raman
eng
uncontrolled
elastomers
eng
uncontrolled
microscopy
Physik
open_access
Institut für Physik und Astronomie
Referiert
Open Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/41351/pmnr458.pdf
41843
2017
2017
eng
1337
1355
19
640
postprint
1
2018-12-21
2018-12-21
--
A comparative survey of the impacts of extreme rainfall in two international case studies
Flooding is assessed as the most important natural hazard in Europe, causing thousands of deaths, affecting millions of people and accounting for large economic losses in the past decade. Little is known about the damage processes associated with extreme rainfall in cities, due to a lack of accurate, comparable and consistent damage data. The objective of this study is to investigate the impacts of extreme rainfall on residential buildings and how affected households coped with these impacts in terms of precautionary and emergency actions. Analyses are based on a unique dataset of damage characteristics and a wide range of potential damage explaining variables at the household level, collected through computer-aided telephone interviews (CATI) and an online survey. Exploratory data analyses based on a total of 859 completed questionnaires in the cities of Munster (Germany) and Amsterdam (the Netherlands) revealed that the uptake of emergency measures is related to characteristics of the hazardous event. In case of high water levels, more efforts are made to reduce damage, while emergency response that aims to prevent damage is less likely to be effective. The difference in magnitude of the events in Munster and Amsterdam, in terms of rainfall intensity and water depth, is probably also the most important cause for the differences between the cities in terms of the suffered financial losses. Factors that significantly contributed to damage in at least one of the case studies are water contamination, the presence of a basement in the building and people's awareness of the upcoming event. Moreover, this study confirms conclusions by previous studies that people's experience with damaging events positively correlates with precautionary behaviour. For improving future damage data acquisition, we recommend the inclusion of cell phones in a CATI survey to avoid biased sampling towards certain age groups.
Postprints der Universität Potsdam : Mathematisch Naturwissenschaftliche Reihe
10.25932/publishup-41843
urn:nbn:de:kobv:517-opus4-418432
1866-8372
online registration
Natural Hazards and Earth System Sciences 17 (2017) 8, pp. 1337–1355 DOI 10.5194/nhess-17-1337-2017
false
false
CC-BY - Namensnennung 4.0 International
Matthieu Spekkers
Viktor Rözer
Annegret Henriette Thieken
Marie-Claire ten Veldhuis
Heidi Kreibich
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
640
eng
uncontrolled
flood-affected residents
eng
uncontrolled
mitigation measures
eng
uncontrolled
private households
eng
uncontrolled
august 2002
eng
uncontrolled
damage
eng
uncontrolled
Germany
eng
uncontrolled
preparedness
eng
uncontrolled
insurance
eng
uncontrolled
recovery
eng
uncontrolled
people
Geografie, Reisen
open_access
Mathematisch-Naturwissenschaftliche Fakultät
Referiert
Open Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/41843/pmnr640.pdf
40332
2017
2017
eng
15
postprint
1
--
2017-11-09
--
A comparison of running kinetics in children with and without genu varus
Introduction
Varus knee alignment has been identified as a risk factor for the progression of medial knee osteoarthritis. However, the underlying mechanisms have not been elucidated yet in children. Thus, the aims of the present study were to examine differences in ground reaction forces, loading rate, impulses, and free moment values during running in children with and without genu varus.
Methods
Thirty-six boys aged 9–14 volunteered to participate in this study. They were divided in two age-matched groups (genu varus versus healthy controls). Body weight adjusted three dimensional kinetic data (Fx, Fy, Fz) were collected during running at preferred speed using two Kistler force plates for the dominant and non-dominant limb.
Results
Individuals with knee genu varus produced significantly higher (p = .01; d = 1.09; 95%) body weight adjusted ground reaction forces in the lateral direction (Fx) of the dominant limb compared to controls. On the non-dominant limb, genu varus patients showed significantly higher body weight adjusted ground reaction forces values in the lateral (p = .01; d = 1.08; 86%) and medial (p < .001; d = 1.55; 102%) directions (Fx). Further, genu varus patients demonstrated 55% and 36% greater body weight adjusted loading rates in the dominant (p < .001; d = 2.09) and non-dominant (p < .001; d = 1.02) leg, respectively. No significant between-group differences were observed for adjusted free moment values (p>.05). Discussion Higher mediolateral ground reaction forces and vertical loading rate amplitudes in boys with genu varus during running at preferred running speed may accelerate the development of progressive joint degeneration in terms of the age at knee osteoarthritis onset. Therefore, practitioners and therapists are advised to conduct balance and strength training programs to improve lower limb alignment and mediolateral control during dynamic movements.
A cross sectional study
urn:nbn:de:kobv:517-opus4-403326
online registration
PLoS ONE 12 (2017) Nr. 9. - DOI: 10.1371/journal.pone.0185057
<a href="http://publishup.uni-potsdam.de/opus4-ubp/frontdoor/index/index/docId/40297">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
CC-BY - Namensnennung 4.0 International
Amir Ali Jafarnezhadgero
Morteza Madadi Shad
Mahdi Majlesi
Urs Granacher
Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe
349
Naturwissenschaften und Mathematik
Medizin und Gesundheit
open_access
Strukturbereich Kognitionswissenschaften
Referiert
Open Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/40332/phr349_online.pdf
41803
2017
2019
eng
12
641
postprint
1
2019-02-21
2019-02-21
--
A complete representation of uncertainties in layer-counted paleoclimatic archives
Accurate time series representation of paleoclimatic proxy records is challenging because such records involve dating errors in addition to proxy measurement errors. Rigorous attention is rarely given to age uncertainties in paleoclimatic research, although the latter can severely bias the results of proxy record analysis. Here, we introduce a Bayesian approach to represent layer-counted proxy records - such as ice cores, sediments, corals, or tree rings - as sequences of probability distributions on absolute, error-free time axes. The method accounts for both proxy measurement errors and uncertainties arising from layer-counting-based dating of the records. An application to oxygen isotope ratios from the North Greenland Ice Core Project (NGRIP) record reveals that the counting errors, although seemingly small, lead to substantial uncertainties in the final representation of the oxygen isotope ratios. In particular, for the older parts of the NGRIP record, our results show that the total uncertainty originating from dating errors has been seriously underestimated. Our method is next applied to deriving the overall uncertainties of the Suigetsu radiocarbon comparison curve, which was recently obtained from varved sediment cores at Lake Suigetsu, Japan. This curve provides the only terrestrial radiocarbon comparison for the time interval 12.5-52.8 kyr BP. The uncertainties derived here can be readily employed to obtain complete error estimates for arbitrary radiometrically dated proxy records of this recent part of the last glacial interval.
Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
10.25932/publishup-41803
urn:nbn:de:kobv:517-opus4-418030
1866-8372
online registration
Climate of the Past 13 (2017), pp. 1169–1180 DOI 10.5194/cp-13-1169-2017
false
true
CC-BY - Namensnennung 4.0 International
Niklas Boers
Bedartha Goswami
Michael Ghil
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
641
eng
uncontrolled
Greenland ice-core
eng
uncontrolled
late-glacial chronology
eng
uncontrolled
high-resolution record
eng
uncontrolled
Lake Suigetsu
eng
uncontrolled
proxy records
eng
uncontrolled
age models
eng
uncontrolled
climate
eng
uncontrolled
events
eng
uncontrolled
Japan
eng
uncontrolled
period
Geowissenschaften
open_access
Mathematisch-Naturwissenschaftliche Fakultät
Referiert
Open Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/41803/pmnr641.pdf
42737
2015
2020
eng
299
304
8
825
postprint
1
2020-02-27
2020-02-27
--
A confidence ellipse for the Net Reclassification Improvement
The Net Reclassification Improvement (NRI) has become a popular metric for evaluating improvement in disease prediction models through the past years. The concept is relatively straightforward but usage and interpretation has been different across studies. While no thresholds exist for evaluating the degree of improvement, many studies have relied solely on the significance of the NRI estimate. However, recent studies recommend that statistical testing with the NRI should be avoided. We propose using confidence ellipses around the estimated values of event and non-event NRIs which might provide the best measure of variability around the point estimates. Our developments are illustrated using practical examples from EPIC-Potsdam study.
Postprints der Universität Potsdam : Mathematisch Naturwissenschaftliche Reihe
10.25932/publishup-42737
urn:nbn:de:kobv:517-opus4-427371
1866-8372
European Journal of Epidemiology 30 (2015) 299–304 DOI:10.1007/s10654-015-0001-1
<a href="http://publishup.uni-potsdam.de/39047">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
CC-BY - Namensnennung 4.0 International
Kristin Mühlenbruch
Olga Kuxhaus
Michael J. Pencina
Heiner Boeing
Hannelore Liero
Matthias Bernd Schulze
eng
uncontrolled
risk assessment
eng
uncontrolled
risk model
eng
uncontrolled
model comparison
eng
uncontrolled
reclassification
eng
uncontrolled
confidence intervals
Medizin und Gesundheit
open_access
Mathematisch-Naturwissenschaftliche Fakultät
Referiert
Open Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/42737/pmnr825.pdf
52208
2021
2021
eng
22
9
postprint
1
2021-09-03
2021-07-14
--
A Conserved Hydrophobic Moiety and Helix-Helix Interactions Drive the Self-Assembly of the Incretin Analog Exendin-4
Exendin-4 is a pharmaceutical peptide used in the control of insulin secretion. Structural information on exendin-4 and related peptides especially on the level of quaternary structure is scarce. We present the first published association equilibria of exendin-4 directly measured by static and dynamic light scattering. We show that exendin-4 oligomerization is pH dependent and that these oligomers are of low compactness. We relate our experimental results to a structural hypothesis to describe molecular details of exendin-4 oligomers. Discussion of the validity of this hypothesis is based on NMR, circular dichroism and fluorescence spectroscopy, and light scattering data on exendin-4 and a set of exendin-4 derived peptides. The essential forces driving oligomerization of exendin-4 are helix–helix interactions and interactions of a conserved hydrophobic moiety. Our structural hypothesis suggests that key interactions of exendin-4 monomers in the experimentally supported trimer take place between a defined helical segment and a hydrophobic triangle constituted by the Phe22 residues of the three monomeric subunits. Our data rationalize that Val19 might function as an anchor in the N-terminus of the interacting helix-region and that Trp25 is partially shielded in the oligomer by C-terminal amino acids of the same monomer. Our structural hypothesis suggests that the Trp25 residues do not interact with each other, but with C-terminal Pro residues of their own monomers.
Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
10.25932/publishup-52208
urn:nbn:de:kobv:517-opus4-522081
1866-8372
<a href="http://publishup.uni-potsdam.de/52207">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
1305
Biomolecules 2021, 11(9), 1305; https://doi.org/10.3390/biom11091305
Thalhammer, Anja
CC-BY - Namensnennung 4.0 International
Martin Wolff
Klaus Gast
Andreas Evers
Michael Kurz
Stefania Pfeiffer-Marek
Anja Schüler
Robert Seckler
Anja Thalhammer
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
1161
eng
uncontrolled
biophysics
eng
uncontrolled
diabetes
eng
uncontrolled
peptides
eng
uncontrolled
oligomerization
eng
uncontrolled
conformational change
eng
uncontrolled
molecular modeling
eng
uncontrolled
static and dynamic light scattering
eng
uncontrolled
spectroscopy
Biowissenschaften; Biologie
open_access
Institut für Biochemie und Biologie
Referiert
Green Open-Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/52208/pmnr1161.pdf
46788
2020
2021
eng
33
706
postprint
1
2021-03-01
2021-03-01
--
A corpus-based analysis of meaning variations in German tag questions evidence from spoken and written conversational corpora
This paper addresses semantic/pragmatic variability of tag questions in German and makes three main contributions. First, we document the prevalence and variety of question tags in German across three different types of conversational corpora. Second, by annotating question tags according to their syntactic and semantic context, discourse function, and pragmatic effect, we demonstrate the existing overlap and differences between the individual tag variants. Finally, we distinguish several groups of question tags by identifying the factors that influence the speakers’ choices of tags in the conversational context, such as clause type, function, speaker/hearer knowledge, as well as conversation type and medium. These factors provide the limits of variability by constraining certain question tags in German against occurring in specific contexts or with individual functions.
Postprints der Universität Potsdam : Humanwissenschaftliche Reihe
10.25932/publishup-46788
urn:nbn:de:kobv:517-opus4-467882
1866-8364
online registration
Corpus Linguistics and Linguistic Theory (2020) DOI: 10.1515/cllt-2019-0060
false
true
CC-BY - Namensnennung 4.0 International
Yulia Clausen
Tatjana Scheffler
Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe
706
eng
uncontrolled
German
eng
uncontrolled
tag questions
eng
uncontrolled
discourse functions
eng
uncontrolled
pragmatic variability
eng
uncontrolled
corpus annotation
Sprache
open_access
Humanwissenschaftliche Fakultät
Referiert
Department Linguistik
Open Access Mitgliedschaft
Green Open-Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/46788/phr706.pdf
1558
1993
eng
postprint
0
2008-03-28
--
--
A daily rainfall erosivity model for Western Amazonia
Rainfall erosivities as defined by the R factor from the universal soil loss equation were determined for all events during a two-year period at the station La Cuenca in western Amazonia. Three methods based on a power relationship between rainfall amount and erosivity were then applied to estimate event and daily rainfall erosivities from the respective rainfall amounts. A test of the resulting regression equations against an independent data set proved all three methods equally adequate in predicting rainfall erosivity from daily rainfall amount. We recommend the Richardson model for testing in the Amazon Basin, and its use with the coefficient from La Cuenca in western Amazonia.
urn:nbn:de:kobv:517-opus-16962
1696
Journal of Soil and Water Conservation. - 48 (1993), 5, p. 439 - 444. - ISSN 0022-4561 (print), 1941-3300 (online)
<hr>
first published in:<br><a href="http://www.swcs.org/en/journal_of_soil_and_water_conservation/"> Journal of Soil and Water Conservation </a> - 48 (1993), 5, p. 439 - 444
<br>
ISSN: 0022-4561 (print), 1941-3300 (online)
Keine öffentliche Lizenz: Unter Urheberrechtsschutz
Helmut Elsenbeer
Keith Cassel
W. Tinner
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
paper 050
eng
uncontrolled
MESOSCALE CONVECTIVE COMPLEXES
eng
uncontrolled
KINETIC-ENERGY
eng
uncontrolled
UNITED-STATES
eng
uncontrolled
EROSION
Geowissenschaften
open_access
Extern
Institut für Geoökologie
Institut für Umweltwissenschaften und Geographie
Universität Potsdam
https://publishup.uni-potsdam.de/files/1558/elsenbeer_etal_1993.pdf
39441
2016
2016
eng
8654
8661
8
postprint
1
--
2016-02-05
--
A detailed assignment of NEXAFS resonances of imidazolium based ionic liquids
In Near Edge X-Ray Absorption Fine Structure (NEXAFS) spectroscopy X-Ray photons are used to excite tightly bound core electrons to low-lying unoccupied orbitals of the system. This technique offers insight into the electronic structure of the system as well as useful structural information. In this work, we apply NEXAFS to two kinds of imidazolium based ionic liquids ([CnC1im]+[NTf2]- and [C4C1im]+[I]-). A combination of measurements and quantum chemical calculations of C K and N K NEXAFS resonances is presented. The simulations, based on the transition potential density functional theory method (TP-DFT), reproduce all characteristic features observed by the experiment. Furthermore, a detailed assignment of resonance features to excitation centers (carbon or nitrogen atoms) leads to a consistent interpretation of the spectra.
urn:nbn:de:kobv:517-opus4-394417
online registration
Au-032781
Phys. Chem. Chem. Phys. (2016) Nr. 18, S. 8654-8661. - DOI: 10.1039/C5CP07434G
Christopher Ehlert
Markus Holzweber
Andreas Lippitz
Wolfgang E. S. Unger
Peter Saalfrank
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
315
eng
uncontrolled
ray absorption-spectroscopy
eng
uncontrolled
fine-structure
eng
uncontrolled
spectra
eng
uncontrolled
simulations
eng
uncontrolled
molecules
eng
uncontrolled
dynamics
eng
uncontrolled
graphene
eng
uncontrolled
surface
eng
uncontrolled
salts
Chemie und zugeordnete Wissenschaften
open_access
Institut für Chemie
Referiert
RSC
Universität Potsdam
https://publishup.uni-potsdam.de/files/39441/pmnr315_online.pdf
42740
2012
2020
eng
12
850
postprint
1
2020-03-16
2020-03-16
--
A distinct metabolic signature predictsdevelopment of fasting plasma glucose
Background
High blood glucose and diabetes are amongst the conditions causing the greatest losses in years of healthy life worldwide. Therefore, numerous studies aim to identify reliable risk markers for development of impaired glucose metabolism and type 2 diabetes. However, the molecular basis of impaired glucose metabolism is so far insufficiently understood. The development of so called 'omics' approaches in the recent years promises to identify molecular markers and to further understand the molecular basis of impaired glucose metabolism and type 2 diabetes. Although univariate statistical approaches are often applied, we demonstrate here that the application of multivariate statistical approaches is highly recommended to fully capture the complexity of data gained using high-throughput methods.
Methods
We took blood plasma samples from 172 subjects who participated in the prospective Metabolic Syndrome Berlin Potsdam follow-up study (MESY-BEPO Follow-up). We analysed these samples using Gas Chromatography coupled with Mass Spectrometry (GC-MS), and measured 286 metabolites. Furthermore, fasting glucose levels were measured using standard methods at baseline, and after an average of six years. We did correlation analysis and built linear regression models as well as Random Forest regression models to identify metabolites that predict the development of fasting glucose in our cohort.
Results
We found a metabolic pattern consisting of nine metabolites that predicted fasting glucose development with an accuracy of 0.47 in tenfold cross-validation using Random Forest regression. We also showed that adding established risk markers did not improve the model accuracy. However, external validation is eventually desirable. Although not all metabolites belonging to the final pattern are identified yet, the pattern directs attention to amino acid metabolism, energy metabolism and redox homeostasis.
Conclusions
We demonstrate that metabolites identified using a high-throughput method (GC-MS) perform well in predicting the development of fasting plasma glucose over several years. Notably, not single, but a complex pattern of metabolites propels the prediction and therefore reflects the complexity of the underlying molecular mechanisms. This result could only be captured by application of multivariate statistical approaches. Therefore, we highly recommend the usage of statistical methods that seize the complexity of the information given by high-throughput methods.
Postprints der Universität Potsdam : Mathematisch Naturwissenschaftliche Reihe
urn:nbn:de:kobv:517-opus4-427400
10.25932/publishup-42740
1866-8372
Journal of Clinical Bioinformatics 2 (2012) 3 DOI: 10.1186/2043-9113-2-3
3
Manuela Hische
Abdelhalim Larhlimi
Franziska Schwarz
Antje Fischer-Rosinský
Thomas Bobbert
Anke Assmann
Gareth S. Catchpole
Andreas F. H. Pfeiffer
Lothar Willmitzer
Joachim Selbig
Joachim Spranger
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
850
eng
uncontrolled
prediction
eng
uncontrolled
fasting glucose
eng
uncontrolled
type 2 diabetes
eng
uncontrolled
metabolomics
eng
uncontrolled
plasma
eng
uncontrolled
random forest
eng
uncontrolled
metabolite
eng
uncontrolled
regression
eng
uncontrolled
biomarker
Chemie und zugeordnete Wissenschaften
open_access
Mathematisch-Naturwissenschaftliche Fakultät
Referiert
Open Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/42740/pmnr850.pdf
41873
2017
2019
eng
17
660
postprint
1
2019-03-01
2019-03-01
--
A dual-biomarker approach for quantification of changes in relative humidity from sedimentary lipid D/H ratios
Past climatic change can be reconstructed from sedimentary archives by a number of proxies. However, few methods exist to directly estimate hydrological changes and even fewer result in quantitative data, impeding our understanding of the timing, magnitude and mechanisms of hydrological changes.
Here we present a novel approach based on delta H-2 values of sedimentary lipid biomarkers in combination with plant physiological modeling to extract quantitative information on past changes in relative humidity. Our initial application to an annually laminated lacustrine sediment sequence from western Europe deposited during the Younger Dryas cold period revealed relative humidity changes of up to 15% over sub-centennial timescales, leading to major ecosystem changes, in agreement with palynological data from the region. We show that by combining organic geochemical methods and mechanistic plant physiological models on well characterized lacustrine archives it is possible to extract quantitative ecohydrological parameters from sedimentary lipid biomarker delta H-2 data.
Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
10.25932/publishup-41873
urn:nbn:de:kobv:517-opus4-418731
1866-8372
online registration
Climate of the Past 13 (2017), pp. 741–757 DOI 10.5194/cp-13-741-2017
false
true
CC-BY - Namensnennung 4.0 International
Oliver Rach
Ansgar Kahmen
Achim Brauer
Dirk Sachse
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
660
eng
uncontrolled
delta-D values
eng
uncontrolled
hydrogen-isotopic composition
eng
uncontrolled
Dryas cold period
eng
uncontrolled
n-alkanes record
eng
uncontrolled
leaf water
eng
uncontrolled
Younger Dryas
eng
uncontrolled
seasonal variation
eng
uncontrolled
Lake sediments
eng
uncontrolled
Central Europe
eng
uncontrolled
climate varibility
Geowissenschaften
open_access
Mathematisch-Naturwissenschaftliche Fakultät
Referiert
Open Access
Copernicus
Universität Potsdam
https://publishup.uni-potsdam.de/files/41873/pmnr660.pdf
42755
2015
2020
eng
12
819
postprint
1
2020-02-18
2020-02-18
--
A flexible approach to assess fluorescence decay functions in complex energy transfer systems
Background: Time-correlated Forster resonance energy transfer (FRET) probes molecular distances with greater accuracy than intensity-based calculation of FRET efficiency and provides a powerful tool to study biomolecular structure and dynamics. Moreover, time-correlated photon count measurements bear additional information on the variety of donor surroundings allowing more detailed differentiation between distinct structural geometries which are typically inaccessible to general fitting solutions.
Results: Here we develop a new approach based on Monte Carlo simulations of time-correlated FRET events to estimate the time-correlated single photon counts (TCSPC) histograms in complex systems. This simulation solution assesses the full statistics of time-correlated photon counts and distance distributions of fluorescently labeled biomolecules. The simulations are consistent with the theoretical predictions of the dye behavior in FRET systems with defined dye distances and measurements of randomly distributed dye solutions. We validate the simulation results using a highly heterogeneous aggregation system and explore the conditions to use this tool in complex systems.
Conclusion: This approach is powerful in distinguishing distance distributions in a wide variety of experimental setups, thus providing a versatile tool to accurately distinguish between different structural assemblies in highly complex systems.
Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe 819
10.25932/publishup-42755
urn:nbn:de:kobv:517-opus4-427557
1866-8372
online registration
BMC Biophysics 8 (2015) 5 DOI: 10.1186/s13628-015-0020-z
<a href="http://publishup.uni-potsdam.de/39014">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
true
true
CC-BY - Namensnennung 4.0 International
Christoph Roethlein
Markus S. Miettinen
Zoya Ignatova
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
819
eng
uncontrolled
time resolved FRET
eng
uncontrolled
Monte-Carlo simulations
eng
uncontrolled
complex heterogeneous systems
eng
uncontrolled
protein aggregation
Biowissenschaften; Biologie
open_access
Mathematisch-Naturwissenschaftliche Fakultät
Referiert
Open Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/42755/pmnr819.pdf
46804
2018
2020
eng
26
1023
13
postprint
1
2020-12-07
2020-12-07
--
A fluctuation in surface temperature in historical context
This work reviews the literature on an alleged global warming 'pause' in global mean surface temperature (GMST) to determine how it has been defined, what time intervals are used to characterise it, what data are used to measure it, and what methods used to assess it. We test for 'pauses', both in the normally understood meaning of the term to mean no warming trend, as well as for a 'pause' defined as a substantially slower trend in GMST. The tests are carried out with the historical versions of GMST that existed for each pause-interval tested, and with current versions of each of the GMST datasets. The tests are conducted following the common (but questionable) practice of breaking the linear fit at the start of the trend interval ('broken' trends), and also with trends that are continuous with the data bordering the trend interval. We also compare results when appropriate allowance is made for the selection bias problem. The results show that there is little or no statistical evidence for a lack of trend or slower trend in GMST using either the historical data or the current data. The perception that there was a 'pause' in GMST was bolstered by earlier biases in the data in combination with incomplete statistical testing.
Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
reassessment and retrospective on the evidence
10.25932/publishup-46804
urn:nbn:de:kobv:517-opus4-468041
1866-8372
online registration
Environmental Research Letters 13 (2018) 123008 DOI: 10.1088/1748-9326/aaf342
123008
<a href="http://publishup.uni-potsdam.de/51083">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
James S. Risbey
Stephan Lewandowsky
Kevin Cowtan
Naomi Oreskes
Stefan Rahmstorf
Ari Jokimäki
Grant Foster
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
1023
eng
uncontrolled
climate variability
eng
uncontrolled
climate trends
eng
uncontrolled
temperature fluctuation
eng
uncontrolled
pause hiatus
Hausbau, Bauhandwerk
open_access
Institut für Physik und Astronomie
Referiert
Green Open-Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/46804/pmnr1023.pdf
44130
2016
2020
eng
2245
2260
18
909
postprint
1
2020-05-25
2020-05-25
--
A framework for lateral membrane trafficking and polar tethering of the PEN3 ATP-Binding cassette transporter
The outermost cell layer of plants, the epidermis, and its outer (lateral) membrane domain facing the environment are continuously challenged by biotic and abiotic stresses. Therefore, the epidermis and the outer membrane domain provide important selective and protective barriers. However, only a small number of specifically outer membrane-localized proteins are known. Similarly, molecular mechanisms underlying the trafficking and the polar placement of outer membrane domain proteins require further exploration. Here, we demonstrate that ACTIN7 (ACT7) mediates trafficking of the PENETRATION3 (PEN3) outer membrane protein from the trans-Golgi network (TGN) to the plasma membrane in the root epidermis of Arabidopsis (Arabidopsis thaliana) and that actin function contributes to PEN3 endocytic recycling. In contrast to such generic ACT7-dependent trafficking from the TGN, the EXOCYST84b (EXO84b) tethering factor mediates PEN3 outer-membrane polarity. Moreover, precise EXO84b placement at the outer membrane domain itself requires ACT7 function. Hence, our results uncover spatially and mechanistically distinct requirements for ACT7 function during outer lateral membrane cargo trafficking and polarity establishment. They further identify an exocyst tethering complex mediator of outer lateral membrane cargo polarity.
Postprints der Universität Potsdam : Mathematisch Naturwissenschaftliche Reihe
10.25932/publishup-44130
urn:nbn:de:kobv:517-opus4-441302
1866-8372
Plant Physiology 172(2016) 4, 2245–2260 DOI:10.1104/pp.16.01252
<a href="http://publishup.uni-potsdam.de/44683">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
CC-BY - Namensnennung 4.0 International
Hailiang Mao
Moritaka Nakamura
Corrado Viotti
Markus Grebe
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
909
eng
uncontrolled
precursor indole-3-butyric acid
eng
uncontrolled
GNOM ARF-GEF
eng
uncontrolled
plasma-membrane
eng
uncontrolled
exocyst complex
eng
uncontrolled
auxin transport
eng
uncontrolled
planar polarity
eng
uncontrolled
Arabidopsis-thaliana
eng
uncontrolled
fluorescent protein
eng
uncontrolled
soil interface
eng
uncontrolled
cell polarity
Pflanzen (Botanik)
open_access
Mathematisch-Naturwissenschaftliche Fakultät
Referiert
Open Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/44130/pmnr909.pdf
40796
2015
2018
eng
14
postprint
1
2018-07-03
2018-07-03
--
A framework for the cross-sectoral integration of multi-model impact projections
Climate change and its impacts already pose considerable challenges for societies that will further increase with global warming (IPCC, 2014a, b). Uncertainties of the climatic response to greenhouse gas emissions include the potential passing of large-scale tipping points (e.g. Lenton et al., 2008; Levermann et al., 2012; Schellnhuber, 2010) and changes in extreme meteorological events (Field et al., 2012) with complex impacts on societies (Hallegatte et al., 2013). Thus climate change mitigation is considered a necessary societal response for avoiding uncontrollable impacts (Conference of the Parties, 2010). On the other hand, large-scale climate change mitigation itself implies fundamental changes in, for example, the global energy system. The associated challenges come on top of others that derive from equally important ethical imperatives like the fulfilment of increasing food demand that may draw on the same resources. For example, ensuring food security for a growing population may require an expansion of cropland, thereby reducing natural carbon sinks or the area available for bio-energy production. So far, available studies addressing this problem have relied on individual impact models, ignoring uncertainty in crop model and biome model projections. Here, we propose a probabilistic decision framework that allows for an evaluation of agricultural management and mitigation options in a multi-impact-model setting. Based on simulations generated within the Inter-Sectoral Impact Model Intercomparison Project (ISI-MIP), we outline how cross-sectorally consistent multi-model impact simulations could be used to generate the information required for robust decision making.
Using an illustrative future land use pattern, we discuss the trade-off between potential gains in crop production and associated losses in natural carbon sinks in the new multiple crop-and biome-model setting. In addition, crop and water model simulations are combined to explore irrigation increases as one possible measure of agricultural intensification that could limit the expansion of cropland required in response to climate change and growing food demand. This example shows that current impact model uncertainties pose an important challenge to long-term mitigation planning and must not be ignored in long-term strategic decision making.
Earth system dynamics
land use decisions under climate impacts uncertainties
urn:nbn:de:kobv:517-opus4-407968
online registration
Earth System Dynamics 6 (2015) Nr. 2, S. 447–460 DOI: 10.5194/esd-6-447-2015
<a href="http://publishup.uni-potsdam.de/opus4-ubp/frontdoor/index/index/docId/39277">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
CC-BY - Namensnennung 4.0 International
Katja Frieler
Anders Levermann
J. Elliott
J. Heinke
A. Arneth
M. F. P. Bierkens
Philippe Ciais
D. B. Clark
D. Deryng
P. Doell
P. Falloon
B. Fekete
Christian Folberth
A. D. Friend
C. Gellhorn
S. N. Gosling
I. Haddeland
N. Khabarov
M. Lomas
Y. Masaki
K. Nishina
K. Neumann
T. Oki
R. Pavlick
A. C. Ruane
E. Schmid
C. Schmitz
T. Stacke
E. Stehfest
Q. Tang
D. Wisser
V. Huber
Franziska Piontek
L. Warszawski
Jacob Schewe
Hermann Lotze-Campen
Hans Joachim Schellnhuber
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
457
eng
uncontrolled
global food demand
eng
uncontrolled
water availability
eng
uncontrolled
elevated CO2
eng
uncontrolled
future
eng
uncontrolled
carbon
eng
uncontrolled
system
eng
uncontrolled
productivity
eng
uncontrolled
agriculture
eng
uncontrolled
emissions
eng
uncontrolled
scarcity
Geowissenschaften
open_access
Mathematisch-Naturwissenschaftliche Fakultät
Referiert
Open Access
Multidisciplinary Digital Publishing Institute (MDPI)
Universität Potsdam
https://publishup.uni-potsdam.de/files/40796/pmnr457.online.pdf
4193
2009
eng
postprint
1
2010-07-06
--
--
A gene marker panel covering the Wnt and the Ras-Raf-MEK-MAPK signalling pathways allows to detect gene mutations in 80% of early (UICC I) colon cancer stages in humans
Background: Very recently a gene marker panel that allows the mutational analysis of APC, CTNNB1, B-RAF and K-RAS was conceived. The aim of the present study was to use the 4-gene marker panel covering the Wnt and Ras-Raf-MEK-MAPK signalling pathways to determine the percentage of sporadic colorectal carcinomas (CRC) carrying at least one of the four above-mentioned genes in a mutated form alone and/or in combination with microsatellite instability (MSI) and to compare the sensitivity of the gene marker panel used in this study with that of gene marker panels previously reported in the scientific literature. Methods: CTNNB1 and B-RAF were screened by PCR-single-strand conformation polymorphism analysis and K-RAS gene mutations by restriction fragment length polymorphism analysis. For the mutational analysis of the APC gene mutation cluster region (codons 1243–1567) direct DNA sequencing was performed. The U.S. National Cancer Institute microsatellite panel (BAT25, BAT26, D2S123, D5S346 and D17S250) was used for MSI analysis. Results: It could be shown that about 80% of early stage CRC (UICC stages I and II) and over 90% of CRC in the UICC stage IV carried at least one mutated gene and/or showed MSI. No significant increase in the gene mutation frequencies could be determined when comparing tumours in the UICC stage I with those in UICC stage IV. Conclusions: When compared with previously published gene marker panels the 4-gene marker panel used in the present study shows an excellent performance, allowing to detect genetic alterations in 80–90% of human sporadic CRC samples analyzed.
urn:nbn:de:kobv:517-opus-44587
4458
Cancer epidemiology 33 (2009), 2, S. 123 - 129, DOI 10.1016/j.canep.2009.05.001
<hr>The original publication is available at:
<br><a href="http://www.sciencedirect.com/">
Elsevier</a><br>
<a href="http://www.sciencedirect.com/science/journal/18777821">Cancer epidemiology</a>. - 33 (2009), 2, S. 123-129<br>
ISSN 1877-7821<br>
DOI <a href="http://dx.doi.org/10.1016/j.canep.2009.05.001"> 10.1016/j.canep.2009.05.001</a>
Keine öffentliche Lizenz: Unter Urheberrechtsschutz
Bettina Scholtka
Mandy Schneider
Ralph Melcher
Tiemo Katzenberger
Daniela Friedrich
Kornelia Berghof-Jäger
Wolfgang Scheppach
Pablo Steinberg
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
paper 120
eng
uncontrolled
Colorectal carcinomas
eng
uncontrolled
K-RAS
eng
uncontrolled
Microsatellite instability
eng
uncontrolled
Oncogenes
eng
uncontrolled
Tumour suppressor genes
Naturwissenschaften und Mathematik
open_access
Institut für Ernährungswissenschaft
Universität Potsdam
https://publishup.uni-potsdam.de/files/4193/pmnf120.pdf
40717
2016
2018
eng
16
postprint
1
2018-06-14
2018-06-14
--
A genetic and chemical perspective on symbiotic recruitment of cyanobacteria of the genus Nostoc into the host plant Blasia pusilla L.
Liverwort Blasia pusilla L. recruits soil nitrogen-fixing cyanobacteria of genus Nostoc as symbiotic partners. In this work we compared Nostoc community composition inside the plants and in the soil around them from two distant locations in Northern Norway. STRR fingerprinting and 16S rDNA phylogeny reconstruction showed a remarkable local diversity among isolates assigned to several Nostoc clades. An extensive web of negative allelopathic interactions was recorded at an agricultural site, but not at the undisturbed natural site. The cell extracts of the cyanobacteria did not show antimicrobial activities, but four isolates were shown to be cytotoxic to human cells. The secondary metabolite profiles of the isolates were mapped by MALDI-TOF MS, and the most prominent ions were further analyzed by Q-TOF for MS/MS aided identification. Symbiotic isolates produced a great variety of small peptide-like substances, most of which lack any record in the databases. Among identified compounds we found microcystin and nodularin variants toxic to eukaryotic cells. Microcystin producing chemotypes were dominating as symbiotic recruits but not in the free-living community. In addition, we were able to identify several novel aeruginosins and banyaside-like compounds, as well as nostocyclopeptides and nosperin.
Frontiers in microbiology
urn:nbn:de:kobv:517-opus4-407179
online registration
Frontiers in microbiology 7 (2016) Art. 1693, DOI: 10.3389/fmicb.2016.01693
CC-BY - Namensnennung 4.0 International
Anton Liaimer
John B. Jensen
Elke Dittmann-Thünemann
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
434
eng
uncontrolled
cyanobacteria
eng
uncontrolled
secondary metabolites
eng
uncontrolled
symbiosis
eng
uncontrolled
Blasia
eng
uncontrolled
Nostoc
eng
uncontrolled
allelopathy
Biowissenschaften; Biologie
open_access
Mathematisch-Naturwissenschaftliche Fakultät
Institut für Biochemie und Biologie
Referiert
Open Access
Frontiers
Universität Potsdam
https://publishup.uni-potsdam.de/files/40717/pmnr434.pdf
41912
2017
2019
eng
29
671
postprint
1
2019-03-06
2019-03-06
--
A high space–time resolution dataset linking meteorological forcing and hydro-sedimentary response in a mesoscale Mediterranean catchment (Auzon) of the Ardèche region, France
A comprehensive hydrometeorological dataset is presented spanning the period 1 January 201131 December 2014 to improve the understanding of the hydrological processes leading to flash floods and the relation between rainfall, runoff, erosion and sediment transport in a mesoscale catchment (Auzon, 116 km(2)) of the Mediterranean region. Badlands are present in the Auzon catchment and well connected to high-gradient channels of bedrock rivers which promotes the transfer of suspended solids downstream. The number of observed variables, the various sensors involved (both in situ and remote) and the space-time resolution (similar to km(2), similar to min) of this comprehensive dataset make it a unique contribution to research communities focused on hydrometeorology, surface hydrology and erosion. Given that rainfall is highly variable in space and time in this region, the observation system enables assessment of the hydrological response to rainfall fields. Indeed, (i) rainfall data are provided by rain gauges (both a research network of 21 rain gauges with a 5 min time step and an operational network of 10 rain gauges with a 5 min or 1 h time step), S-band Doppler dual-polarization radars (1 km(2), 5 min resolution), disdrometers (16 sensors working at 30 s or 1 min time step) and Micro Rain Radars (5 sensors, 100m height resolution). Additionally, during the special observation period (SOP-1) of the HyMeX (Hydrological Cycle in the Mediterranean Experiment) project, two X-band radars provided precipitation measurements at very fine spatial and temporal scales (1 ha, 5 min). (ii) Other meteorological data are taken from the operational surface weather observation stations of Meteo-France (including 2m air temperature, atmospheric pressure, 2 m relative humidity, 10m wind speed and direction, global radiation) at the hourly time resolution (six stations in the region of interest). (iii) The monitoring of surface hydrology and suspended sediment is multi-scale and based on nested catchments. Three hydrometric stations estimate water discharge at a 2-10 min time resolution. Two of these stations also measure additional physico-chemical variables (turbidity, temperature, conductivity) and water samples are collected automatically during floods, allowing further geochemical characterization of water and suspended solids. Two experimental plots monitor overland flow and erosion at 1 min time resolution on a hillslope with vineyard. A network of 11 sensors installed in the intermittent hydrographic network continuously measures water level and water temperature in headwater subcatchments (from 0.17 to 116 km(2)) at a time resolution of 2-5 min. A network of soil moisture sensors enables the continuous measurement of soil volumetric water content at 20 min time resolution at 9 sites. Additionally, concomitant observations (soil moisture measurements and stream gauging) were performed during floods between 2012 and 2014. Finally, this dataset is considered appropriate for understanding the rainfall variability in time and space at fine scales, improving areal rainfall estimations and progressing in distributed hydrological and erosion modelling.
Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
10.25932/publishup-41912
urn:nbn:de:kobv:517-opus4-419127
1866-8372
online registration
Earth System Science Data 9 (2017) DOI 10.5194/essd-9-221-2017
<a href="http://publishup.uni-potsdam.de/55196">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
CC-BY - Namensnennung 4.0 International
Guillaume Nord
Brice Boudevillain
Alexis Berne
Flora Branger
Isabelle Braud
Guillaume Dramais
Simon Gérard
Jérôme Le Coz
Cédric Legoût
Gilles Molinié
Joel Van Baelen
Jean-Pierre Vandervaere
Julien Andrieu
Coralie Aubert
Martin Calianno
Guy Delrieu
Jacopo Grazioli
Sahar Hachani
Ivan Horner
Jessica Huza
Raphaël Le Boursicaud
Timothy H. Raupach
Adriaan J. Teuling
Magdalena Uber
Béatrice Vincendon
Annette Wijbrans
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
671
eng
uncontrolled
hydraulic properties
eng
uncontrolled
soil moisture
eng
uncontrolled
flash floods
eng
uncontrolled
rainfall
eng
uncontrolled
radar
eng
uncontrolled
scale
eng
uncontrolled
variability
eng
uncontrolled
transport
eng
uncontrolled
erosion
eng
uncontrolled
model
Geowissenschaften
open_access
Mathematisch-Naturwissenschaftliche Fakultät
Referiert
Open Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/41912/pmnr671.pdf
52425
2020
2019
eng
14
5
postprint
1
2020-02-05
2019-09-04
--
A highly efficient agrobacterium-mediated method for transient gene expression and functional studies in multiple plant species
Although the use of stable transformation technology has led to great insight into gene function, its application in high-throughput studies remains arduous. Agro-infiltration have been widely used in species such as Nicotiana benthamiana for the rapid detection of gene expression and protein interaction analysis, but this technique does not work efficiently in other plant species, including Arabidopsis thaliana. As an efficient high-throughput transient expression system is currently lacking in the model plant species A. thaliana, we developed a method that is characterized by high efficiency, reproducibility, and suitability for transient expression of a variety of functional proteins in A. thaliana and 7 other plant species, including Brassica oleracea, Capsella rubella, Thellungiella salsuginea, Thellungiella halophila, Solanum tuberosum, Capsicum annuum, and N. benthamiana. Efficiency of this method was independently verified in three independent research facilities, pointing to the robustness of this technique. Furthermore, in addition to demonstrating the utility of this technique in a range of species, we also present a case study employing this method to assess protein-protein interactions in the sucrose biosynthesis pathway in Arabidopsis.
Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
urn:nbn:de:kobv:517-opus4-524254
1866-8372
10.25932/publishup-52425
<a href="http://publishup.uni-potsdam.de/52502">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
100028
Plant Communications, Volume 1, Issue 5, 2020, 100028, ISSN 2590-3462, https://doi.org/10.1016/j.xplc.2020.100028
Version of record
CC-BY-NC-ND - Namensnennung, nicht kommerziell, keine Bearbeitungen 4.0 International
Youjun Zhang
Moxian Chen
Beata Siemiatkowska
Mitchell Rey Toleco
Yue Jing
Vivien Strotmann
Jianghua Zhang
Yvonne Stahl
Alisdair R. Fernie
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
1189
eng
uncontrolled
transient expression
eng
uncontrolled
agro-infiltration
eng
uncontrolled
subcellular localization
eng
uncontrolled
protein-protein interaction
Biowissenschaften; Biologie
open_access
Institut für Biochemie und Biologie
Referiert
Green Open-Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/52425/pmnr1189.pdf
4263
2010
eng
postprint
0
2010-07-13
--
--
A highly efficient pipeline for protein expression in Leishmania tarentolae sing infrared fluorescence protein as marker
Background: Leishmania tarentolae, a unicellular eukaryotic protozoan, has been established as a novel host for recombinant protein production in recent years. Current protocols for protein expression in Leishmania are, however, time consuming and require extensive lab work in order to identify well-expressing cell lines. Here we established an alternative protein expression work-flow that employs recently engineered infrared fluorescence protein (IFP) as a suitable and easy-to-handle reporter protein for recombinant protein expression in Leishmania. As model proteins we tested three proteins from the plant Arabidopsis thaliana, including a NAC and a type-B ARR transcription factor. Results: IFP and IFP fusion proteins were expressed in Leishmania and rapidly detected in cells by deconvolution microscopy and in culture by infrared imaging of 96-well microtiter plates using small cell culture volumes (2 μL - 100 μL). Motility, shape and growth of Leishmania cells were not impaired by intracellular accumulation of IFP. In-cell detection of IFP and IFP fusion proteins was straightforward already at the beginning of the expression pipeline and thus allowed early pre-selection of well-expressing Leishmania clones. Furthermore, IFP fusion proteins retained infrared fluorescence after electrophoresis in denaturing SDS-polyacrylamide gels, allowing direct in-gel detection without the need to disassemble cast protein gels. Thus, parameters for scaling up protein production and streamlining purification routes can be easily optimized when employing IFP as reporter. Conclusions: Using IFP as biosensor we devised a protocol for rapid and convenient protein expression in Leishmania tarentolae. Our expression pipeline is superior to previously established methods in that it significantly reduces the hands-on-time and work load required for identifying well-expressing clones, refining protein production parameters and establishing purification protocols. The facile in-cell and in-gel detection tools built on IFP make Leishmania amenable for high-throughput expression of proteins from plant and animal sources.
urn:nbn:de:kobv:517-opus-44773
4477
Microbial cell factories 9 (2010), Art. 29, DOI 10.1186/1475-2859-9-29
<hr>The article was originally published by Biomed Central:
<br><a href="http://www.microbialcellfactories.com/home/">
Microbial Cell Factories</a>. - 9 (2010), Art. 29<br>
ISSN 1475-2859<br>
DOI <a href="http://dx.doi.org/10.1186/1475-2859-9-29"> 10.1186/1475-2859-9-29</a>
Hakan Dortay
Bernd Müller-Röber
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
paper 122
eng
uncontrolled
System
eng
uncontrolled
Donovani
Biowissenschaften; Biologie
open_access
Institut für Biochemie und Biologie
Universität Potsdam
https://publishup.uni-potsdam.de/files/4263/pmnf122.pdf
40087
2017
2017
eng
10
postprint
1
--
2017-09-28
--
A highly efficient pipeline for protein expression in Leishmania tarentolae using infrared fluorescence protein as marker
Background: Leishmania tarentolae, a unicellular eukaryotic protozoan, has been established as a novel host for recombinant protein production in recent years. Current protocols for protein expression in Leishmania are, however, time consuming and require extensive lab work in order to identify well-expressing cell lines. Here we established an alternative protein expression work-flow that employs recently engineered infrared fluorescence protein (IFP) as a suitable and easy-to-handle reporter protein for recombinant protein expression in Leishmania. As model proteins we tested three proteins from the plant Arabidopsis thaliana, including a NAC and a type-B ARR transcription factor.
Results: IFP and IFP fusion proteins were expressed in Leishmania and rapidly detected in cells by deconvolution microscopy and in culture by infrared imaging of 96-well microtiter plates using small cell culture volumes (2 mu L - 100 mu L). Motility, shape and growth of Leishmania cells were not impaired by intracellular accumulation of IFP. In-cell detection of IFP and IFP fusion proteins was straightforward already at the beginning of the expression pipeline and thus allowed early pre-selection of well-expressing Leishmania clones. Furthermore, IFP fusion proteins retained infrared fluorescence after electrophoresis in denaturing SDS-polyacrylamide gels, allowing direct in-gel detection without the need to disassemble cast protein gels. Thus, parameters for scaling up protein production and streamlining purification routes can be easily optimized when employing IFP as reporter.
Conclusions: Using IFP as biosensor we devised a protocol for rapid and convenient protein expression in Leishmania tarentolae. Our expression pipeline is superior to previously established methods in that it significantly reduces the hands-on-time and work load required for identifying well-expressing clones, refining protein production parameters and establishing purification protocols. The facile in-cell and in-gel detection tools built on IFP make Leishmania amenable for high-throughput expression of proteins from plant and animal sources.
urn:nbn:de:kobv:517-opus4-400876
online registration
Microbial cell factories 9 (2010). - DOI: 10.1186/1475-2859-9-29
29
CC-BY - Namensnennung 4.0 International
Hakan Dortay
Bernd Müller-Röber
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
366
eng
uncontrolled
System
eng
uncontrolled
Donovani
Biowissenschaften; Biologie
Medizin und Gesundheit
open_access
Institut für Biochemie und Biologie
Referiert
Open Access
BioMed Central
Universität Potsdam
https://publishup.uni-potsdam.de/files/40087/pmnr366_online.pdf
43565
2019
2019
eng
14
745
postprint
1
2019-10-02
2019-10-02
--
A high‑throughput amplicon‑based method for estimating outcrossing rates
Background: The outcrossing rate is a key determinant of the population-genetic structure of species and their long-term evolutionary trajectories. However, determining the outcrossing rate using current methods based on PCRgenotyping individual offspring of focal plants for multiple polymorphic markers is laborious and time-consuming.
Results: We have developed an amplicon-based, high-throughput enabled method for estimating the outcrossing rate and have applied this to an example of scented versus non-scented Capsella (Shepherd’s Purse) genotypes. Our results show that the method is able to robustly capture differences in outcrossing rates. They also highlight potential biases in the estimates resulting from differential haplotype sharing of the focal plants with the pollen-donor population at individual amplicons.
Conclusions: This novel method for estimating outcrossing rates will allow determining this key population-genetic parameter with high-throughput across many genotypes in a population, enabling studies into the genetic determinants of successful pollinator attraction and outcrossing.
Postprints der Universität Potsdam Mathematisch-Naturwissenschaftliche Reihe
10.25932/publishup-43565
urn:nbn:de:kobv:517-opus4-435657
1866-8372
Plant Methods 15 (2019) 47 DOI: 10.1186/s13007-019-0433-9
<a href="http://publishup.uni-potsdam.de/opus4-ubp/frontdoor/index/index/docId/43564">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
false
true
CC-BY - Namensnennung 4.0 International
Friederike Jantzen
Natalia Joanna Wozniak
Christian Kappel
Adrien Sicard
Michael Lenhard
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
745
eng
uncontrolled
Outcrossing
eng
uncontrolled
Mixed mating
eng
uncontrolled
Outcrossing rate
eng
uncontrolled
Capsella
eng
uncontrolled
Amplicon sequencing
Biowissenschaften; Biologie
Pflanzen (Botanik)
open_access
Institut für Biochemie und Biologie
Referiert
Open Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/43565/pmnr745.pdf
43547
2014
2020
eng
577
587
13
885
postprint
1
2020-04-20
2020-04-20
--
A Lefschetz fixed point formula for elliptic quasicomplexes
In a recent paper, the Lefschetz number for endomorphisms (modulo trace class operators) of sequences of trace class curvature was introduced. We show that this is a well defined, canonical extension of the classical Lefschetz number and establish the homotopy invariance of this number. Moreover, we apply the results to show that the Lefschetz fixed point formula holds for geometric quasiendomorphisms of elliptic quasicomplexes.
Postprints der Universität Potsdam : Mathematisch Naturwissenschaftliche Reihe
10.25932/publishup-43547
urn:nbn:de:kobv:517-opus4-435471
1866-8372
Integral Equations and Operator Theory 78 (2014) 577–587 DOI: 10.1007/s00020-014-2122-4
Keine öffentliche Lizenz: Unter Urheberrechtsschutz
Daniel Wallenta
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
885
eng
uncontrolled
elliptic complexes
eng
uncontrolled
Fredholm complexes
eng
uncontrolled
Lefschetz number
Datenverarbeitung; Informatik
Mathematik
open_access
Mathematisch-Naturwissenschaftliche Fakultät
Referiert
Open Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/43547/pmnr885.pdf
5505
2009
eng
postprint
0
2011-12-12
--
--
A linear mixed model analysis of masked repetition priming
We examined individual differences in masked repetition priming by re-analyzing item-level response-time (RT) data from three experiments. Using a linear mixed model (LMM) with subjects and items specified as crossed random factors, the originally reported priming and word-frequency effects were recovered. In the same LMM, we estimated parameters describing the distributions of these effects across subjects. Subjects’ frequency and priming effects correlated positively with each other and negatively with mean RT. These correlation estimates, however, emerged only with a reciprocal transformation of RT (i.e., -1/RT), justified on the basis of distributional analyses. Different correlations, some with opposite sign, were obtained (1) for untransformed or logarithmic RTs or (2) when correlations were computed using within-subject analyses. We discuss the relevance of the new results for accounts of masked priming, implications of applying RT transformations, and the use of LMMs as a tool for the joint analysis of experimental effects and associated individual differences.
urn:nbn:de:kobv:517-opus-57073
5707
Visual Cognition. - ISSN 1464-0716. - 18 (2010), 5, S. 655 - 681
This is a preprint of an article whose final and definitive form was published in <a href="http://www.tandf.co.uk/journals/pp/13506285.html">Visual Cognition</a><br/>
Kliegl, Reinhold , Masson, Michael E. J. and Richter, Eike M.(2010):'A linear mixed model analysis of masked repetition priming', Visual Cognition, 18: 5, 655 — 681, First published on: 03 August 2009. (iFirst)<br/>
<a href="http://dx.doi.org/10.1080/13506280902986058">DOI: 10.1080/13506280902986058</a>
2009 Taylor & Francis
Keine öffentliche Lizenz: Unter Urheberrechtsschutz
Reinhold Kliegl
Michael E. J. Masson
Eike M. Richter
Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe
paper 247
Sprache
open_access
Extern
Department Psychologie
Institut für Psychologie
Universität Potsdam
https://publishup.uni-potsdam.de/files/5505/phr_247_2011_12_12.pdf
55925
2022
2022
eng
1
14
14
postprint
Universitätsverlag Potsdam
Potsdam
1
2022-08-23
2022-08-23
--
A Link between Handgrip Strength and Executive Functioning: A Cross-Sectional Study in Older Adults with Mild Cognitive Impairment and Healthy Controls
Older adults with amnestic mild cognitive impairment (aMCI) who in addition to their memory deficits also suffer from frontal-executive dysfunctions have a higher risk of developing dementia later in their lives than older adults with aMCI without executive deficits and older adults with non-amnestic MCI (naMCI). Handgrip strength (HGS) is also correlated with the risk of cognitive decline in the elderly. Hence, the current study aimed to investigate the associations between HGS and executive functioning in individuals with aMCI, naMCI and healthy controls. Older, right-handed adults with amnestic MCI (aMCI), non-amnestic MCI (naMCI), and healthy controls (HC) conducted a handgrip strength measurement via a handheld dynamometer. Executive functions were assessed with the Trail Making Test (TMT A&B). Normalized handgrip strength (nHGS, normalized to Body Mass Index (BMI)) was calculated and its associations with executive functions (operationalized through z-scores of TMT B/A ratio) were investigated through partial correlation analyses (i.e., accounting for age, sex, and severity of depressive symptoms). A positive and low-to-moderate correlation between right nHGS (rp (22) = 0.364; p = 0.063) and left nHGS (rp (22) = 0.420; p = 0.037) and executive functioning in older adults with aMCI but not in naMCI or HC was observed. Our results suggest that higher levels of nHGS are linked to better executive functioning in aMCI but not naMCI and HC. This relationship is perhaps driven by alterations in the integrity of the hippocampal-prefrontal network occurring in older adults with aMCI. Further research is needed to provide empirical evidence for this assumption.
Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe
10.25932/publishup-55925
urn:nbn:de:kobv:517-opus4-559251
1866-8364
230
Version of record
<a href="http://publishup.uni-potsdam.de/opus4-ubp/frontdoor/index/index/docId/55924">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
Herold, Fabian
false
true
CC-BY - Namensnennung 4.0 International
Fabian Herold
Berit K. Labott
Bernhard Grässler
Nicole Halfpaap
Corinna Langhans
Patrick Müller
Achraf Ammar
Milos Dordevic
Anita Hökelmann
Notger Germar Müller
Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe
775
eng
uncontrolled
MCI
eng
uncontrolled
hippocampal-prefrontal network
eng
uncontrolled
handgrip strength
eng
uncontrolled
exercise cognition
eng
uncontrolled
aging
eng
uncontrolled
brain health
Medizin und Gesundheit
open_access
Referiert
Green Open-Access
Fakultät für Gesundheitswissenschaften
Universität Potsdam
https://publishup.uni-potsdam.de/files/55925/phr775.pdf
5717
2006
deu
postprint
1
2012-08-13
--
--
A love supreme : Jazzthetic strategies in Toni Morrison's Beloved
urn:nbn:de:kobv:517-opus-60446
6044
African American Review. - ISSN: 1062-4783. - 40 (2006) 2, S. 271-283
This article was first published in the <a href="http://aar.slu.edu/">African American Review</a>: African American Review. - 40 (2006) 2, p. 271-283</br>
ISSN: 1446-8123
Keine öffentliche Lizenz: Unter Urheberrechtsschutz
Lars Eckstein
Zweitveröffentlichungen der Universität Potsdam : Philosophische Reihe
85
Amerikanische Literatur in in Englisch
open_access
Institut für Anglistik und Amerikanistik
Universität Potsdam
https://publishup.uni-potsdam.de/files/5717/eckstein_a_love_supreme.pdf
4322
2009
eng
postprint
1
2010-07-20
--
--
A macro-tidal freshwater ecosystem recovering from hypereutrophication : the Schelde lease study
We report a 40 year record of eutrophication and hypoxia on an estuarine ecosystem and its recovery from hypereutrophication. After decades of high inorganic nutrient concentrations and recurring anoxia and hypoxia, we observe a paradoxical increase in chlorophyll-a concentrations with decreasing nutrient inputs. We hypothesise that algal growth was inhibited due to hypereutrophication, either by elevated ammonium concentrations, severe hypoxia or the production of harmful substances in such a reduced environment. We study the dynamics of a simple but realistic mathematical model, incorporating the assumption of algal growth inhibition. It shows a high algal biomass, net oxygen production equilibrium with low ammonia inputs, and a low algal biomass, net oxygen consumption equilibrium with high ammonia inputs. At intermediate ammonia inputs it displays two alternative stable states. Although not intentional, the numerical output of this model corresponds to observations, giving extra support for assumption of algal growth inhibition. Due to potential algal growth inhibition, the recovery of hypereutrophied systems towards a classical eutrophied state, will need reduction of waste loads below certain thresholds and will be accompanied by large fluctuations in oxygen concentrations. We conclude that also flow-through systems, heavily influenced by external forcings which partly mask internal system dynamics, can display multiple stable states.
urn:nbn:de:kobv:517-opus-45180
4518
Biogeosciences, 6 (2009), 12, S. 2935 - 2948
<hr>The article was originally published by Copernicus Publications:
<br><a href="http://www.biogeosciences.net/">
Biogeosciences</a>. - 6 (2009), 12, S. 2935 - 2948<br>
ISSN 1726-4170<br>
Tom Cox
Tom Maris
Karline Soetart
Daniel Conley
Stefan van Damme
Patrick Meire
Jack J. Middelburg
Matthijs Vos
Eric Struyf
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
paper 144
eng
uncontrolled
Estuary SW Netherlands
eng
uncontrolled
southern North-Sea
eng
uncontrolled
Past 50 years
eng
uncontrolled
Westerschelde estuary
eng
uncontrolled
Marine ecosystems
Biowissenschaften; Biologie
open_access
Institut für Biochemie und Biologie
Universität Potsdam
https://publishup.uni-potsdam.de/files/4322/pmnf144.pdf
41773
2018
2018
eng
14
472
postprint
1
2018-10-10
2018-10-10
--
A Meta-Analysis to Determine Strength Training Related Dose-Response Relationships for Lower-Limb Muscle Power Development in Young Athletes
It is well-documented that strength training (ST) improves measures of muscle strength in young athletes. Less is known on transfer effects of ST on proxies of muscle power and the underlying dose-response relationships. The objectives of this meta-analysis were to quantify the effects of ST on lower limb muscle power in young athletes and to provide dose-response relationships for ST modalities such as frequency, intensity, and volume. A systematic literature search of electronic databases identified 895 records. Studies were eligible for inclusion if (i) healthy trained children (girls aged 6–11 y, boys aged 6–13 y) or adolescents (girls aged 12–18 y, boys aged 14–18 y) were examined, (ii) ST was compared with an active control, and (iii) at least one proxy of muscle power [squat jump (SJ) and countermovement jump height (CMJ)] was reported. Weighted mean standardized mean differences (SMDwm) between subjects were calculated. Based on the findings from 15 statistically aggregated studies, ST produced significant but small effects on CMJ height (SMDwm = 0.65; 95% CI 0.34–0.96) and moderate effects on SJ height (SMDwm = 0.80; 95% CI 0.23–1.37). The sub-analyses revealed that the moderating variable expertise level (CMJ height: p = 0.06; SJ height: N/A) did not significantly influence ST-related effects on proxies of muscle power. “Age” and “sex” moderated ST effects on SJ (p = 0.005) and CMJ height (p = 0.03), respectively. With regard to the dose-response relationships, findings from the meta-regression showed that none of the included training modalities predicted ST effects on CMJ height. For SJ height, the meta-regression indicated that the training modality “training duration” significantly predicted the observed gains (p = 0.02), with longer training durations (>8 weeks) showing larger improvements. This meta-analysis clearly proved the general effectiveness of ST on lower-limb muscle power in young athletes, irrespective of the moderating variables. Dose-response analyses revealed that longer training durations (>8 weeks) are more effective to improve SJ height. No such training modalities were found for CMJ height. Thus, there appear to be other training modalities besides the ones that were included in our analyses that may have an effect on SJ and particularly CMJ height. ST monitoring through rating of perceived exertion, movement velocity or force-velocity profile could be promising monitoring tools for lower-limb muscle power development in young athletes.
Postprints der Universität Potsdam : Humanwissenschaftliche Reihe
urn:nbn:de:kobv:517-opus4-417738
online registration
Frontiers in Physiology 9 (2018) Art. 1155 DOI: 10.3389/fphys.2018.01155
<a href="http://publishup.uni-potsdam.de/opus4-ubp/frontdoor/index/index/docId/41772">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
CC-BY - Namensnennung 4.0 International
Maamer Slimani
Armin Paravlic
Urs Granacher
Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe
472
eng
uncontrolled
resistance training
eng
uncontrolled
muscle fitness
eng
uncontrolled
youth
eng
uncontrolled
meta-analysis
eng
uncontrolled
jump performance
Medizin und Gesundheit
open_access
Strukturbereich Kognitionswissenschaften
Referiert
Open Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/41773/phr472.online.pdf
42756
2015
2020
eng
13
820
postprint
1
2020-02-19
2020-02-19
--
A mindfulness-based stress prevention training for medical students (MediMind)
Background: Medical training is very demanding and associated with a high prevalence of psychological distress. Compared to the general population, medical students are at a greater risk of developing a psychological disorder. Various attempts of stress management training in medical school have achieved positive results on minimizing psychological distress; however, there are often limitations. Therefore, the use of a rigorous scientific method is needed. The present study protocol describes a randomized controlled trial to examine the effectiveness of a specifically developed mindfulness-based stress prevention training for medical students that includes selected elements of cognitive behavioral strategies (MediMind).
Methods/Design: This study protocol presents a prospective randomized controlled trial, involving four assessment time points: baseline, post-intervention, one-year follow-up and five-year follow-up. The aims include evaluating the effect on stress, coping, psychological morbidity and personality traits with validated measures. Participants are allocated randomly to one of three conditions: MediMind, Autogenic Training or control group. Eligible participants are medical or dental students in the second or eighth semester of a German university. They form a population of approximately 420 students in each academic term. A final total sample size of 126 (at five-year follow-up) is targeted. The trainings (MediMind and Autogenic Training) comprise five weekly sessions lasting 90 minutes each. MediMind will be offered to participants of the control group once the five-year follow-up is completed. The allotment is randomized with a stratified allocation ratio by course of studies, semester, and gender. After descriptive statistics have been evaluated, inferential statistical analysis will be carried out with a repeated measures ANOVA-design with interactions between time and group. Effect sizes will be calculated using partial η-square values.
Discussion: Potential limitations of this study are voluntary participation and the risk of attrition, especially concerning participants that are allocated to the control group. Strengths are the study design, namely random allocation, follow-up assessment, the use of control groups and inclusion of participants at different stages of medical training with the possibility of differential analysis.
Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe 820
study protocol for a randomized controlled trial
10.25932/publishup-42756
urn:nbn:de:kobv:517-opus4-427568
1866-8372
online registration
Trials 16 (2015) 40 DOI: 10.1186/s13063-014-0533-9
<a href="http://publishup.uni-potsdam.de/39166">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
Sophie Merle Kuhlmann
Arne Bürger
Günter Esser
Florian Hammerle
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
820
eng
uncontrolled
psychometric properties
eng
uncontrolled
psychological distress
eng
uncontrolled
predicting stress
eng
uncontrolled
German version
eng
uncontrolled
mental-health
eng
uncontrolled
self-esteem
eng
uncontrolled
reduction
eng
uncontrolled
depression
eng
uncontrolled
management
eng
uncontrolled
benefits
Medizin und Gesundheit
open_access
Mathematisch-Naturwissenschaftliche Fakultät
Referiert
Open Access
Department Psychologie
Institut für Psychologie
Universität Potsdam
https://publishup.uni-potsdam.de/files/42756/pmnr820.pdf
43626
2016
2020
eng
19
890
postprint
1
2020-04-21
2020-04-21
--
A minimal model of self-consistent partial synchrony
We show that self-consistent partial synchrony in globally coupled oscillatory ensembles is a general phenomenon. We analyze in detail appearance and stability properties of this state in possibly the simplest setup of a biharmonic Kuramoto-Daido phase model as well as demonstrate the effect in limit-cycle relaxational Rayleigh oscillators. Such a regime extends the notion of splay state from a uniform distribution of phases to an oscillating one. Suitable collective observables such as the Kuramoto order parameter allow detecting the presence of an inhomogeneous distribution. The characteristic and most peculiar property of self-consistent partial synchrony is the difference between the frequency of single units and that of the macroscopic field.
Postprints der Universität Potsdam : Mathematisch Naturwissenschaftliche Reihe
10.25932/publishup-43626
urn:nbn:de:kobv:517-opus4-436266
1866-8372
New Journal of Physics 18 (2016) DOI: 10.1088/1367-2630/aa722b
<a href="http://publishup.uni-potsdam.de/44952">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
Pau Clusella
Antonio Politi
Michael Rosenblum
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
890
eng
uncontrolled
synchronization
eng
uncontrolled
collective dynamics
eng
uncontrolled
coupled oscillators
Physik
open_access
Mathematisch-Naturwissenschaftliche Fakultät
Referiert
Open Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/43626/pmnr890.pdf
44080
2017
2019
eng
8
793
postprint
1
2019-12-16
2019-12-16
--
A mitogenomic timetree for Darwin's enigmatic South American mammal Macrauchenia patachonica
The unusual mix of morphological traits displayed by extinct South American native ungulates (SANUs) confounded both Charles Darwin, who first discovered them, and Richard Owen, who tried to resolve their relationships. Here we report an almost complete mitochondrial genome for the litoptern Macrauchenia. Our dated phylogenetic tree places Macrauchenia as sister to Perissodactyla, but close to the radiation of major lineages within Laurasiatheria. This position is consistent with a divergence estimate of B66Ma (95% credibility interval, 56.64-77.83 Ma) obtained for the split between Macrauchenia and other Panperissodactyla. Combined with their morphological distinctiveness, this evidence supports the positioning of Litopterna (possibly in company with other SANU groups) as a separate order within Laurasiatheria. We also show that, when using strict criteria, extinct taxa marked by deep divergence times and a lack of close living relatives may still be amenable to palaeogenomic analysis through iterative mapping against more distant relatives.
Postprints der Universität Potsdam Mathematisch-Naturwissenschaftliche Reihe
urn:nbn:de:kobv:517-opus4-440801
10.25932/publishup-44080
1866-8372
online registration
Nature Communications 8 (2017) Art. 15951 DOI: 10.1038/ncomms15951
false
true
CC-BY - Namensnennung 4.0 International
Michael V. Westbury
Sina Isabelle Baleka
Axel Barlow
Stefanie Hartmann
Johanna L. A. Paijmans
Alejandro Kramarz
Analía M. Forasiepi
Mariano Bond
Javier N. Gelfo
Marcelo A. Reguero
Patricio López-Mendoza
Matias Taglioretti
Fernando Scaglia
Andrés Rinderknecht
Washington Jones
Francisco Mena
Guillaume Billet
Christian de Muizon
José Luis Aguilar
Ross D.E. MacPhee
Michael Hofreiter
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
793
eng
uncontrolled
ancient DNA
eng
uncontrolled
evolutionary history
eng
uncontrolled
genome sequence
eng
uncontrolled
reveals
eng
uncontrolled
contamination
eng
uncontrolled
alignment
eng
uncontrolled
reads
eng
uncontrolled
bones
Naturwissenschaften und Mathematik
open_access
Mathematisch-Naturwissenschaftliche Fakultät
Referiert
Open Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/44080/pmnr793.pdf
40718
2016
2018
eng
12
postprint
1
2018-06-18
2018-06-18
--
A model analysis of mechanisms for radial microtubular patterns at root hair initiation sites
Plant cells have two main modes of growth generating anisotropic structures. Diffuse growth where whole cell walls extend in specific directions, guided by anisotropically positioned cellulose fibers, and tip growth, with inhomogeneous addition of new cell wall material at the tip of the structure. Cells are known to regulate these processes via molecular signals and the cytoskeleton. Mechanical stress has been proposed to provide an input to the positioning of the cellulose fibers via cortical microtubules in diffuse growth. In particular, a stress feedback model predicts a circumferential pattern of fibers surrounding apical tissues and growing primordia, guided by the anisotropic curvature in such tissues. In contrast, during the initiation of tip growing root hairs, a star-like radial pattern has recently been observed. Here, we use detailed finite element models to analyze how a change in mechanical properties at the root hair initiation site can lead to star-like stress patterns in order to understand whether a stress-based feedback model can also explain the microtubule patterns seen during root hair initiation. We show that two independent mechanisms, individually or combined, can be sufficient to generate radial patterns. In the first, new material is added locally at the position of the root hair. In the second, increased tension in the initiation area provides a mechanism. Finally, we describe how a molecular model of Rho-of-plant (ROP) GTPases activation driven by auxin can position a patch of activated ROP protein basally along a 2D root epidermal cell plasma membrane, paving the way for models where mechanical and molecular mechanisms cooperate in the initial placement and outgrowth of root hairs.
Frontiers in plant science
urn:nbn:de:kobv:517-opus4-407181
online registration
Frontiers in plant science 7 (2016) Art. 1560, DOI: 10.3389/fpls.2016.01560
CC-BY - Namensnennung 4.0 International
Pawel Krupinski
Behruz Bozorg
André Larsson
Stefano Pietra
Markus Grebe
Henrik Jönsson
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
435
eng
uncontrolled
plant cell wall
eng
uncontrolled
finite element modeling
eng
uncontrolled
computational morphodynamics
eng
uncontrolled
root hair initiation
eng
uncontrolled
microtubules
eng
uncontrolled
cellulose fibers
eng
uncontrolled
composite material
Biowissenschaften; Biologie
open_access
Mathematisch-Naturwissenschaftliche Fakultät
Institut für Biochemie und Biologie
Referiert
Open Access
Frontiers
Universität Potsdam
https://publishup.uni-potsdam.de/files/40718/pmnr_435.online.pdf
52325
2021
2021
eng
21
1172
postprint
1
2021-09-21
2021-07-07
--
A model for the relationship between rainfall, GNSS-derived integrated water vapour, and CAPE in the eastern central Andes
Atmospheric water vapour content is a key variable that controls the development of deep convective storms and rainfall extremes over the central Andes. Direct measurements of water vapour are challenging; however, recent developments in microwave processing allow the use of phase delays from L-band radar to measure the water vapour content throughout the atmosphere: Global Navigation Satellite System (GNSS)-based integrated water vapour (IWV) monitoring shows promising results to measure vertically integrated water vapour at high temporal resolutions. Previous works also identified convective available potential energy (CAPE) as a key climatic variable for the formation of deep convective storms and rainfall in the central Andes. Our analysis relies on GNSS data from the Argentine Continuous Satellite Monitoring Network, Red Argentina de Monitoreo Satelital Continuo (RAMSAC) network from 1999 to 2013. CAPE is derived from version 2.0 of the ECMWF’s (European Centre for Medium-Range Weather Forecasts) Re-Analysis (ERA-interim) and rainfall from the TRMM (Tropical Rainfall Measuring Mission) product. In this study, we first analyse the rainfall characteristics of two GNSS-IWV stations by comparing their complementary cumulative distribution function (CCDF). Second, we separately derive the relation between rainfall vs. CAPE and GNSS-IWV. Based on our distribution fitting analysis, we observe an exponential relation of rainfall to GNSS-IWV. In contrast, we report a power-law relationship between the daily mean value of rainfall and CAPE at the GNSS-IWV station locations in the eastern central Andes that is close to the theoretical relationship based on parcel theory. Third, we generate a joint regression model through a multivariable regression analysis using CAPE and GNSS-IWV to explain the contribution of both variables in the presence of each other to extreme rainfall during the austral summer season. We found that rainfall can be characterised with a higher statistical significance for higher rainfall quantiles, e.g., the 0.9 quantile based on goodness-of-fit criterion for quantile regression. We observed different contributions of CAPE and GNSS-IWV to rainfall for each station for the 0.9 quantile. Fourth, we identify the temporal relation between extreme rainfall (the 90th, 95th, and 99th percentiles) and both GNSS-IWV and CAPE at 6 h time steps. We observed an increase before the rainfall event and at the time of peak rainfall—both for GNSS-integrated water vapour and CAPE. We show higher values of CAPE and GNSS-IWV for higher rainfall percentiles (99th and 95th percentiles) compared to the 90th percentile at a 6-h temporal scale. Based on our correlation analyses and the dynamics of the time series, we show that both GNSS-IWV and CAPE had comparable magnitudes, and we argue to consider both climatic variables when investigating their effect on rainfall extremes.
Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
10.25932/publishup-52325
urn:nbn:de:kobv:517-opus4-523256
1866-8372
<a href="http://publishup.uni-potsdam.de/52324">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
Remote Sens. 2021, 13(18), 3788; https://doi.org/10.3390/rs13183788
Version of record
CC-BY - Namensnennung 4.0 International
Maryam Ramezani Ziarani
Bodo Bookhagen
Torsten Schmidt
Jens Wickert
Alejandro de la Torre
Zhiguo Deng
Andrea Calori
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
1172
eng
uncontrolled
Global Navigation Satellite System (GNSS)
eng
uncontrolled
GNSS-integrated water vapour
eng
uncontrolled
convective available potential energy (CAPE)
eng
uncontrolled
extreme rainfall
eng
uncontrolled
TRMM
Geowissenschaften
open_access
Institut für Geowissenschaften
Referiert
Green Open-Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/52325/pmnr1172.pdf
47343
2019
2019
eng
19
1335
postprint
1
2019-05-10
2019-05-10
--
A modified asymptotical regularization of nonlinear ill-posed problems
In this paper, we investigate the continuous version of modified iterative Runge–Kutta-type methods for nonlinear inverse ill-posed problems proposed in a previous work. The convergence analysis is proved under the tangential cone condition, a modified discrepancy principle, i.e., the stopping time T is a solution of ∥𝐹(𝑥𝛿(𝑇))−𝑦𝛿∥=𝜏𝛿+ for some 𝛿+>𝛿, and an appropriate source condition. We yield the optimal rate of convergence.
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
10.25932/publishup-47343
urn:nbn:de:kobv:517-opus4-473433
1866-8372
online registration
Version of record
Mathematics 7 (2019) 419 DOI:10.3390/math7050419
Pornsawad, Pornsarp
<a href="https://publishup.uni-potsdam.de/59913">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
false
true
CC-BY - Namensnennung 4.0 International
Pornsarp Pornsawad
Nantawan Sapsakul
Christine Böckmann
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
1335
eng
uncontrolled
nonlinear operator
eng
uncontrolled
regularization
eng
uncontrolled
discrepancy principle
eng
uncontrolled
asymptotic method
eng
uncontrolled
optimal rate
Mathematik
open_access
Institut für Mathematik
Referiert
Green Open-Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/47343/zmnr1335.pdf
4030
1994
eng
postprint
0
2010-04-29
--
--
A modulated mirror for atomic interferometry
A novel atomic beam splitter, using reflection of atoms off an evanescent light wave, is investigated theoretically. The intensity or frequency of the light is modulated in order to create sidebands on the reflected de Broglie wave. The weights and phases of the various sidevands are calculated using three different approaches: the Born approximation, a semiclassical path integral approach, and a numerical solution of the time-dependent Schrdinger equation. We show how this modulated mirror could be used to build practical atomic interferometers.
urn:nbn:de:kobv:517-opus-42279
4227
Journal de Physique 4 (1994) 11, S. 1877-1896
<hr>The preprint is available at ArXiv.org:
<br>
<a href="http://de.arxiv.org/abs/quant-ph/0408156">Atomic diffraction by a thin phase grating</a>; In: Journal de Physique. - 4 (1994) 11, S. 1877-1896<br>
egger@...
Keine öffentliche Lizenz: Unter Urheberrechtsschutz
Carsten Henkel
Andrew M. Steane
Robin Kaiser
Jean Dalibard
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
paper 102
Physik
open_access
Institut für Physik und Astronomie
Universität Potsdam
https://publishup.uni-potsdam.de/files/4030/modulated.pdf
52194
2021
2021
eng
20
postprint
1
2021-09-02
2021-06-08
--
A molecular relay race: sequential first-passage events to the terminal reaction centre in a cascade of diffusion controlled processes
We consider a sequential cascade of molecular first-reaction events towards a terminal reaction centre in which each reaction step is controlled by diffusive motion of the particles. The model studied here represents a typical reaction setting encountered in diverse molecular biology systems, in which, e.g. a signal transduction proceeds via a series of consecutive 'messengers': the first messenger has to find its respective immobile target site triggering a launch of the second messenger, the second messenger seeks its own target site and provokes a launch of the third messenger and so on, resembling a relay race in human competitions. For such a molecular relay race taking place in infinite one-, two- and three-dimensional systems, we find exact expressions for the probability density function of the time instant of the terminal reaction event, conditioned on preceding successful reaction events on an ordered array of target sites. The obtained expressions pertain to the most general conditions: number of intermediate stages and the corresponding diffusion coefficients, the sizes of the target sites, the distances between them, as well as their reactivities are arbitrary.
Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
10.25932/publishup-52194
urn:nbn:de:kobv:517-opus4-521942
1866-8372
<a href="http://publishup.uni-potsdam.de/52193">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
093004
Denis S Grebenkov et al 2021 New J. Phys. 23 093004
true
true
CC-BY - Namensnennung 4.0 International
Denis S. Grebenkov
Ralf Metzler
Gleb Oshanin
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
1159
eng
uncontrolled
diffusion
eng
uncontrolled
reaction cascade
eng
uncontrolled
first passage time
Astronomie und zugeordnete Wissenschaften
Physik
open_access
Institut für Physik und Astronomie
Referiert
Green Open-Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/52194/pmnr1159.pdf
48483
2020
2020
eng
21
1021
postprint
1
2020-12-01
2020-12-01
--
A Multi-Endpoint Approach to Base Excision Repair Incision Activity Augmented by PARylation and DNA Damage Levels in Mice
Investigation of processes that contribute to the maintenance of genomic stability is one crucial factor in the attempt to understand mechanisms that facilitate ageing. The DNA damage response (DDR) and DNA repair mechanisms are crucial to safeguard the integrity of DNA and to prevent accumulation of persistent DNA damage. Among them, base excision repair (BER) plays a decisive role. BER is the major repair pathway for small oxidative base modifications and apurinic/apyrimidinic (AP) sites. We established a highly sensitive non-radioactive assay to measure BER incision activity in murine liver samples. Incision activity can be assessed towards the three DNA lesions 8-oxo-2’-deoxyguanosine (8-oxodG), 5-hydroxy-2’-deoxyuracil (5-OHdU), and an AP site analogue. We applied the established assay to murine livers of adult and old mice of both sexes. Furthermore, poly(ADP-ribosyl)ation (PARylation) was assessed, which is an important determinant in DDR and BER. Additionally, DNA damage levels were measured to examine the overall damage levels. No impact of ageing on the investigated endpoints in liver tissue were found. However, animal sex seems to be a significant impact factor, as evident by sex-dependent alterations in all endpoints investigated. Moreover, our results revealed interrelationships between the investigated endpoints indicative for the synergetic mode of action of the cellular DNA integrity maintaining machinery.
Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
Impact of Sex and Age
10.25932/publishup-48483
urn:nbn:de:kobv:517-opus4-484831
1866-8372
International Journal of Molecular Sciences 21 (2020) 18, Art. 6600 DOI: 10.3390/ijms21186600
6600
<a href="http://publishup.uni-potsdam.de/48482">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
<a href="http://publishup.uni-potsdam.de/52554">This article is part of this cumulative dissertation</a>
CC-BY - Namensnennung 4.0 International
Nicola Lisa Winkelbeiner
Viktoria Klara Veronika Wandt
Franziska Ebert
Kristina Lossow
Ezgi E. Bankoglu
Maximilian Martin
Aswin Mangerich
Helga Stopper
Julia Bornhorst
Anna Patricia Kipp
Tanja Schwerdtle
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
1021
eng
uncontrolled
maintenance of genomic integrity
eng
uncontrolled
ageing
eng
uncontrolled
sex
eng
uncontrolled
DNA damage
eng
uncontrolled
base excision repair (incision activity)
eng
uncontrolled
DNA damage response
eng
uncontrolled
poly(ADP-ribosyl)ation
eng
uncontrolled
liver
Chemie und zugeordnete Wissenschaften
Biowissenschaften; Biologie
open_access
Institut für Ernährungswissenschaft
Referiert
Green Open-Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/48483/pmnr1021.pdf
40289
2017
2017
eng
34
postprint
1
--
2017-12-01
--
A multi-paradigm approach supporting the modular execution of reconfigurable hybrid systems
Advanced mechatronic systems have to integrate existing technologies from mechanical, electrical and software engineering. They must be able to adapt their structure and behavior at runtime by reconfiguration to react flexibly to changes in the environment. Therefore, a tight integration of structural and behavioral models of the different domains is required. This integration results in complex reconfigurable hybrid systems, the execution logic of which cannot be addressed directly with existing standard modeling, simulation, and code-generation techniques. We present in this paper how our component-based approach for reconfigurable mechatronic systems, M ECHATRONIC UML, efficiently handles the complex interplay of discrete behavior and continuous behavior in a modular manner. In addition, its extension to even more flexible reconfiguration cases is presented.
urn:nbn:de:kobv:517-opus4-402896
online registration
Simulation : transactions of the Society for Modeling and Simulation International Nr. 87 (2011), S. 775-808. - DOI: 10.1177/0037549710366824
Keine öffentliche Lizenz: Unter Urheberrechtsschutz
Holger Giese
Stefan Henkler
Martin Hirsch
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
410
eng
uncontrolled
code generation
eng
uncontrolled
hybrid systems
eng
uncontrolled
reconfigurable systems
eng
uncontrolled
simulation
Datenverarbeitung; Informatik
open_access
Referiert
Open Access
Hasso-Plattner-Institut für Digital Engineering GmbH
Sage
Universität Potsdam
https://publishup.uni-potsdam.de/files/40289/pmnr410_online.pdf
8959
2015
eng
14088
14095
postprint
1
--
--
--
A multi-reference study of the byproduct formation for a ring-closed dithienylethene photoswitch
Photodriven molecular switches are sometimes hindered in their performance by forming byproducts which act as dead ends in sequences of switching cycles, leading to rapid fatigue effects. Understanding the reaction pathways to unwanted byproducts is a prerequisite for preventing them. This article presents a study of the photochemical reaction pathways for byproduct formation in the photochromic switch 1,2-bis-(3-thienyl)-ethene. Specifically, using single- and multi-reference methods the post-deexcitation reaction towards the byproduct in the electronic ground state S0 when starting from the S1–S0 conical intersection (CoIn), is considered in detail. We find an unusual low-energy pathway, which offers the possibility for the formation of a dyotropic byproduct. Several high-energy pathways can be excluded with high probability.
urn:nbn:de:kobv:517-opus4-89594
online registration
Phys. Chem. Chem. Phys. (2015) Nr. 17, 14088-14095. - DOI: 10.1039/C5CP00987A
Au 018534
<a href="http://publishup.uni-potsdam.de/opus4-ubp/frontdoor/index/index/docId/8958">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
Jochen René Matis
Jan Boyke Schönborn
Peter Saalfrank
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
215
Chemie und zugeordnete Wissenschaften
Institut für Chemie
Referiert
Open Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/8959/pmnr215.pdf
40980
2016
2019
eng
18
556
postprint
1
2019-01-29
2019-01-29
--
A multi-stage 3-D stress field modelling approach exemplified in the Bavarian Molasse Basin
The knowledge of the contemporary in situ stress state is a key issue for safe and sustainable subsurface engineering. However, information on the orientation and magnitudes of the stress state is limited and often not available for the areas of interest. Therefore 3-D geomechanical-numerical modelling is used to estimate the in situ stress state and the distance of faults from failure for application in subsurface engineering. The main challenge in this approach is to bridge the gap in scale between the widely scattered data used for calibration of the model and the high resolution in the target area required for the application. We present a multi-stage 3-D geomechanical-numerical approach which provides a state-of-the-art model of the stress field for a reservoir-scale area from widely scattered data records. Therefore, we first use a large-scale regional model which is calibrated by available stress data and provides the full 3-D stress tensor at discrete points in the entire model volume. The modelled stress state is used subsequently for the calibration of a smaller-scale model located within the large-scale model in an area without any observed stress data records. We exemplify this approach with two-stages for the area around Munich in the German Molasse Basin. As an example of application, we estimate the scalar values for slip tendency and fracture potential from the model results as measures for the criticality of fault reactivation in the reservoir-scale model. The modelling results show that variations due to uncertainties in the input data are mainly introduced by the uncertain material properties and missing S-Hmax magnitude estimates needed for a more reliable model calibration. This leads to the conclusion that at this stage the model's reliability depends only on the amount and quality of available stress information rather than on the modelling technique itself or on local details of the model geometry. Any improvements in modelling and increases in model reliability can only be achieved using more high-quality data for calibration.
Postprints der Universität Potsdam Mathematisch-Naturwissenschaftliche Reihe
urn:nbn:de:kobv:517-opus4-409806
10.25932/publishup-40980
1866-8372
online registration
Solid Earth 7 (2016) 5, S. 1365–1382 DOI: 10.5194/se-7-1365-2016
true
true
CC-BY - Namensnennung 4.0 International
Moritz O. Ziegler
Oliver Heidbach
John Reinecker
Anna M. Przybycin
Magdalena Scheck-Wenderoth
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
556
eng
uncontrolled
in-situ stress
eng
uncontrolled
induced seismicity
eng
uncontrolled
geothermal-reservoirs
eng
uncontrolled
geomechanical model
eng
uncontrolled
fault reactivation
eng
uncontrolled
alpine foreland
eng
uncontrolled
map project
eng
uncontrolled
km depth
eng
uncontrolled
orientation
eng
uncontrolled
system
Geowissenschaften
open_access
Mathematisch-Naturwissenschaftliche Fakultät
Referiert
Open Access
Copernicus
Universität Potsdam
https://publishup.uni-potsdam.de/files/40980/pmnr556.pdf
58777
2022
2022
eng
17
157
postprint
1
2022-09-26
2022-09-26
--
A multidimensional and analytical perspective on Open Educational Practices in the 21st century
Participatory approaches to teaching and learning are experiencing a new lease on life in the 21st century as a result of the rapid technology development. Knowledge, practices, and tools can be shared across spatial and temporal boundaries in higher education by means of Open Educational Resources, Massive Open Online Courses, and open-source technologies. In this context, the Open Education Movement calls for new didactic approaches that encourage greater learner participation in formal higher education. Based on a representative literature review and focus group research, in this study an analytical framework was developed that enables researchers and practitioners to assess the form of participation in formal, collaborative teaching and learning practices. The analytical framework is focused on the micro-level of higher education, in particular on the interaction between students and lecturers when organizing the curriculum. For this purpose, the research reflects anew on the concept of participation, taking into account existing stage models for participation in the educational context. These are then brought together with the dimensions of teaching and learning processes, such as methods, objectives and content, etc. This paper aims to make a valuable contribution to the opening up of learning and teaching, and expands the discourse around possibilities for interpreting Open Educational Practices.
Zweitveröffentlichungen der Universität Potsdam : Wirtschaft- und Sozialwissenschaftliche Reihe
10.25932/publishup-58777
urn:nbn:de:kobv:517-opus4-587770
1867-5808
Version of record
<a href="http://publishup.uni-potsdam.de/58776">Bibliographieeintrag der Originalveröffentlichung</a>
Frontiers in Education 7 (2022), Art. 990675. DOI: https://doi.org/0.3389/feduc.2022.990675
false
false
CC-BY - Namensnennung 4.0 International
Bonny Brandenburger
Zweitveröffentlichungen der Universität Potsdam : Wirtschafts- und Sozialwissenschaftliche Reihe
157
eng
uncontrolled
open education
eng
uncontrolled
Open Educational Practices
eng
uncontrolled
participation
eng
uncontrolled
focus group research
eng
uncontrolled
analytical framework for Participatory Educational Practices
eng
uncontrolled
teaching and learning process
Bildung und Erziehung
open_access
Referiert
Fachgruppe Betriebswirtschaftslehre
Green Open-Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/58777/zwsr157.pdf
52565
2020
2019
eng
19
8
postprint
1
2020-07-13
2019-11-18
--
A multidimensional framework for measuring biotic novelty: How novel is a community?
Anthropogenic changes in climate, land use, and disturbance regimes, as well as introductions of non-native species can lead to the transformation of many ecosystems. The resulting novel ecosystems are usually characterized by species assemblages that have not occurred previously in a given area. Quantifying the ecological novelty of communities (i.e., biotic novelty) would enhance the understanding of environmental change. However, quantification remains challenging since current novelty metrics, such as the number and/or proportion of non-native species in a community, fall short of considering both functional and evolutionary aspects of biotic novelty. Here, we propose the Biotic Novelty Index (BNI), an intuitive and flexible multidimensional measure that combines (a) functional differences between native and non-native introduced species with (b) temporal dynamics of species introductions. We show that the BNI is an additive partition of Rao's quadratic entropy, capturing the novel interaction component of the community's functional diversity. Simulations show that the index varies predictably with the relative amount of functional novelty added by recently arrived species, and they illustrate the need to provide an additional standardized version of the index. We present a detailed R code and two applications of the BNI by (a) measuring changes of biotic novelty of dry grassland plant communities along an urbanization gradient in a metropolitan region and (b) determining the biotic novelty of plant species assemblages at a national scale. The results illustrate the applicability of the index across scales and its flexibility in the use of data of different quality. Both case studies revealed strong connections between biotic novelty and increasing urbanization, a measure of abiotic novelty. We conclude that the BNI framework may help building a basis for better understanding the ecological and evolutionary consequences of global change.
Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
10.25932/publishup-52565
urn:nbn:de:kobv:517-opus4-525657
1866-8372
<a href="http://publishup.uni-potsdam.de/52715">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
Version of records
Glob Change Biol. 2020; 26: 4401– 4417. https://doi.org/10.1111/gcb.15140
true
true
CC-BY - Namensnennung 4.0 International
Conrad Schittko
Maud Bernard-Verdier
Tina Heger
Sascha Buchholz
Ingo Kowarik
Moritz von der Lippe
Birgit Seitz
Jasmin Radha Joshi
Jonathan M. Jeschke
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
1209
eng
uncontrolled
alien species
eng
uncontrolled
biological invasions
eng
uncontrolled
coexistence
eng
uncontrolled
ecological novelty
eng
uncontrolled
functional diversity
eng
uncontrolled
novel ecosystems
eng
uncontrolled
novel species
eng
uncontrolled
standard metrics
Pflanzen (Botanik)
open_access
Institut für Biochemie und Biologie
Referiert
Green Open-Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/52565/pmnr1209.pdf
8659
2015
eng
postprint
1
--
2015-12-04
--
A Multifunctional Frontloading Approach for Repeated Recycling of a Pressure-Controlled AFM Micropipette
Fluid force microscopy combines the positional accuracy and force sensitivity of an atomic
force microscope (AFM) with nanofluidics via a microchanneled cantilever. However, adequate loading and cleaning procedures for such AFM micropipettes are required for various application situations. Here, a new frontloading procedure is described for an AFM micropipette functioning as a force- and pressure-controlled microscale liquid dispenser. This frontloading
procedure seems especially attractive when using target substances featuring high
costs or low available amounts. Here, the AFM micropipette could be filled from the tip side with liquid from a previously applied droplet with a volume of only a few μL using a short low-pressure pulse. The liquid-loaded AFM micropipettes could be then applied for experiments in air or liquid environments. AFM micropipette frontloading was evaluated with the well-known organic fluorescent dye rhodamine 6G and the AlexaFluor647-labeled antibody goat anti-rat IgG as an example of a larger biological compound. After micropipette usage, specific cleaning procedures were tested. Furthermore, a storage method is described, at which the AFM micropipettes could be stored for a few hours up to several days without drying out or clogging of the microchannel. In summary, the rapid, versatile and cost-efficient
frontloading and cleaning procedure for the repeated usage of a single AFM micropipette is beneficial for various application situations from specific surface modifications through to local manipulation of living cells, and provides a simplified and faster handling for already known experiments with fluid force microscopy.
urn:nbn:de:kobv:517-opus4-86592
online registration
<a href="http://publishup.uni-potsdam.de/opus4-ubp/frontdoor/index/index/docId/8658">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
PLoS ONE 10(12) (2015) - DOI: 10.1371/journal.pone.0144157
CC-BY - Namensnennung 4.0 International
Phillip Roder
Carsten Hille
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
209
Naturwissenschaften und Mathematik
Medizin und Gesundheit
Institut für Chemie
Referiert
Open Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/8659/pmnr_209.pdf
9874
2014
eng
postprint
1
--
--
--
A multilayered sulfonated polyaniline network with entrapped pyrroloquinoline quinone-dependent glucose dehydrogenase
A feasible approach to construct multilayer films of sulfonated polyanilines – PMSA1 and PABMSA1 – containing different ratios of aniline, 2-methoxyaniline-5-sulfonic acid (MAS) and 3-aminobenzoic acid (AB), with the entrapped redox enzyme pyrroloquinoline quinone-dependent glucose dehydrogenase (PQQ-GDH) on Au and ITO electrode surfaces, is described. The formation of layers has been followed and confirmed by electrochemical impedance spectroscopy (EIS), which demonstrates that the multilayer assembly can be achieved in a progressive and uniform manner. The gold and ITO electrodes subsequently modified with PMSA1:PQQ-GDH and PABMSA1 films are studied by cyclic voltammetry (CV) and UV-Vis spectroscopy which show a significant direct bioelectrocatalytical response to the oxidation of the substrate glucose without any additional mediator. This response correlates linearly with the number of deposited layers. Furthermore, the constructed polymer/enzyme multilayer system exhibits a rather good long-term stability, since the catalytic current response is maintained for more than 60% of the initial value even after two weeks of storage. This verifies that a productive interaction of the enzyme embedded in the film of substituted polyaniline can be used as a basis for the construction of bioelectronic units, which are useful as indicators for processes liberating glucose and allowing optical and electrochemical transduction.
tunable direct bioelectrocatalysis
urn:nbn:de:kobv:517-opus4-98744
online registration
J. Mater. Chem. B, (2014) Nr. 2, S. 3196-3203. - DOI: 10.1039/C4TB00336E
Keine öffentliche Lizenz: Unter Urheberrechtsschutz
David Sarauli
Chenggang Xu
Birgit Dietzel
Burkhard Schulz
Fred Lisdat
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
275
Chemie und zugeordnete Wissenschaften
Biowissenschaften; Biologie
Medizin und Gesundheit
open_access
Institut für Chemie
Referiert
Open Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/9874/pmnr275_online.pdf
3667
1996
eng
postprint
0
2009-11-24
--
--
A multiperspective comparison of peer sociometric status groups in childhood and adolescense
This study explores the sociometric status group differences in psychosocial adjustment and academic performance in various domains using multiple sources of information (teacher-, peer-, self-ratings, achievement data) and 2 age groups (elementary and secondary school students) in a different educational and cultural context. Gender differences in the profiles of the sociometric groups were also examined. The sample consisted of 1,041 elementary school (mean age = 11.4 years) and 862 secondary school (mean age = 14.3 years) students in public schools in Greece. Findings extended previous descriptions of rejected, neglected, and controversial groups based on the perceptions of all raters. Gender and age differences were found in the profiles of rejected and controversial groups, which were markedly distinguished from the other groups based on all data sets. Neglected children at both age levels were differentiated to a weaker degree.
urn:nbn:de:kobv:517-opus-38361
3836
Child Developement 67 (1996) 3, S. 1085 - 1102, ISSN 1467-8624, DOI 10.1111/j.1467-8624.1996.tb01784.x
<hr>The original publication is available at www3.interscience.wiley.com:
<br><a href="http://www3.interscience.wiley.com/journal/117957161/home">
Child Developement</a>. - 67 (1996) Issue 3, p. 1085-1102<br>
ISSN 1467-8624<br>
DOI <a href="http://dx.doi.org/10.1111/j.1467-8624.1996.tb01784.x"> 10.1111/j.1467-8624.1996.tb01784.x</a>
egger@...
Keine öffentliche Lizenz: Unter Urheberrechtsschutz
Chryse Hatzichristou
Diether Hopf
Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe
paper 125
Bildung und Erziehung
open_access
Department Erziehungswissenschaft
Institut für Erziehungswissenschaft
Universität Potsdam
https://publishup.uni-potsdam.de/files/3667/Multiperspective_Comparison_1996.pdf
42757
2010
2020
eng
14
833
postprint
1
2020-03-05
2020-03-05
--
A mutation in the cytosolic O-acetylserine (thiol) lyase induces a genome-dependent early leaf death phenotype in Arabidopsis
Background: Cysteine is a component in organic compounds including glutathione that have been implicated in the adaptation of plants to stresses. O-acetylserine (thiol) lyase (OAS-TL) catalyses the final step of cysteine biosynthesis. OAS-TL enzyme isoforms are localised in the cytoplasm, the plastids and mitochondria but the contribution of individual OAS-TL isoforms to plant sulphur metabolism has not yet been fully clarified.
Results: The seedling lethal phenotype of the Arabidopsis onset of leaf death3-1 (old3-1) mutant is due to a point mutation in the OAS-A1 gene, encoding the cytosolic OAS-TL. The mutation causes a single amino acid substitution from Gly(162) to Glu(162), abolishing old3-1 OAS-TL activity in vitro. The old3-1 mutation segregates as a monogenic semidominant trait when backcrossed to its wild type accession Landsberg erecta (Ler-0) and the Di-2 accession. Consistent with its semi-dominant behaviour, wild type Ler-0 plants transformed with the mutated old3-1 gene, displayed the early leaf death phenotype. However, the old3-1 mutation segregates in an 11: 4: 1 (wild type: semi-dominant: mutant) ratio when backcrossed to the Colombia-0 and Wassilewskija accessions. Thus, the early leaf death phenotype depends on two semi-dominant loci. The second locus that determines the old3-1 early leaf death phenotype is referred to as odd-ler (for old3 determinant in the Ler accession) and is located on chromosome 3. The early leaf death phenotype is temperature dependent and is associated with increased expression of defence-response and oxidative-stress marker genes. Independent of the presence of the odd-ler gene, OAS-A1 is involved in maintaining sulphur and thiol levels and is required for resistance against cadmium stress.
Conclusions: The cytosolic OAS-TL is involved in maintaining organic sulphur levels. The old3-1 mutation causes genome-dependent and independent phenotypes and uncovers a novel function for the mutated OAS-TL in cell death regulation.
Postprints der Universität Potsdam : Mathematisch Naturwissenschaftliche Reihe
10.25932/publishup-42757
urn:nbn:de:kobv:517-opus4-427574
1866-8372
BMC Plant Biology 10 (2010) 80 DOI: 10.1186/1471-2229-10-80
80
Reza Shirzadian-Khorramabad
Hai-Chun Jing
Gerja E. Everts
Jos H. M. Schippers
Jacques Hille
Paul P. Dijkwel
eng
uncontrolled
acyltransferase gene family
eng
uncontrolled
cysteine synthase complex
eng
uncontrolled
map-based cloning
eng
uncontrolled
serine acetyltransferase
eng
uncontrolled
o-acetylserine(thiol)lyase gene
eng
uncontrolled
amino-acids
eng
uncontrolled
glutathione homeostasis
eng
uncontrolled
functional-analysis
eng
uncontrolled
sulfur metabolism
eng
uncontrolled
cadmium tolerance
Pflanzen (Botanik)
Medizin und Gesundheit
open_access
Mathematisch-Naturwissenschaftliche Fakultät
Referiert
Open Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/42757/pmnr833.pdf
41909
2017
2017
eng
75
89
15
625
postprint
1
2019-02-19
2019-02-19
--
A network-based detection scheme for the jet stream core
The polar and subtropical jet streams are strong upper-level winds with a crucial influence on weather throughout the Northern Hemisphere midlatitudes. In particular, the polar jet is located between cold arctic air to the north and warmer subtropical air to the south. Strongly meandering states therefore often lead to extreme surface weather.
Some algorithms exist which can detect the 2-D (latitude and longitude) jets' core around the hemisphere, but all of them use a minimal threshold to determine the subtropical and polar jet stream. This is particularly problematic for the polar jet stream, whose wind velocities can change rapidly from very weak to very high values and vice versa.
We develop a network-based scheme using Dijkstra's shortest-path algorithm to detect the polar and subtropical jet stream core. This algorithm not only considers the commonly used wind strength for core detection but also takes wind direction and climatological latitudinal position into account. Furthermore, it distinguishes between polar and subtropical jet, and between separate and merged jet states.
The parameter values of the detection scheme are optimized using simulated annealing and a skill function that accounts for the zonal-mean jet stream position (Rikus, 2015). After the successful optimization process, we apply our scheme to reanalysis data covering 1979-2015 and calculate seasonal-mean probabilistic maps and trends in wind strength and position of jet streams.
We present longitudinally defined probability distributions of the positions for both jets for all on the Northern Hemisphere seasons. This shows that winter is characterized by two well-separated jets over Europe and Asia (ca. 20 degrees W to 140 degrees E). In contrast, summer normally has a single merged jet over the western hemisphere but can have both merged and separated jet states in the eastern hemisphere.
With this algorithm it is possible to investigate the position of the jets' cores around the hemisphere and it is therefore very suitable to analyze jet stream patterns in observations and models, enabling more advanced model-validation.
Postprints der Universität Potsdam : Mathematisch Naturwissenschaftliche Reihe
10.25932/publishup-41909
urn:nbn:de:kobv:517-opus4-419099
1866-8372
online registration
Earth System Dynamics 8 (2017) 1, pp. 75–89 DOI 10.5194/esd-8-75-2017
<a href="http://publishup.uni-potsdam.de/55340">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
CC-BY - Namensnennung 4.0 International
Sonja Molnos
Tarek Mamdouh
Stefan Petri
Thomas Nocke
Tino Weinkauf
Dim Coumou
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
625
eng
uncontrolled
Southern-Hemisphere
eng
uncontrolled
variability
eng
uncontrolled
weather
eng
uncontrolled
driven
eng
uncontrolled
amplification
eng
uncontrolled
circulation
eng
uncontrolled
reanalysis
eng
uncontrolled
extremes
eng
uncontrolled
climate
eng
uncontrolled
summer
Geowissenschaften
open_access
Mathematisch-Naturwissenschaftliche Fakultät
Referiert
Open Access
Copernicus
Universität Potsdam
https://publishup.uni-potsdam.de/files/41909/pmnr625.pdf
10272
2015
2015
eng
101408
101411
postprint
1
--
2015-11-11
--
A new and environmentally benign synthesis of aroylguanidines using iron trichloride
A new synthetic approach for the guanylation of aroylthioureas using iron trichloride is presented. Our synthetic method distinguishes itself by benign reaction conditions, low costs and a broad product spectrum. The scope of the reaction and calorimetric studies are described.
urn:nbn:de:kobv:517-opus4-102720
online registration
Keine öffentliche Lizenz: Unter Urheberrechtsschutz
Simon Pape
Pablo Wessig
Heiko Brunner
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
308
Chemie und zugeordnete Wissenschaften
open_access
Institut für Chemie
Referiert
Open Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/10272/pmnr308_online.pdf
44222
2019
2020
eng
20
805
postprint
1
2020-01-13
2020-01-13
--
A New Approach of Extraction of α-Amylase/trypsin Inhibitors from Wheat (Triticum aestivum L.), Based on Optimization Using Plackett–Burman and Box–Behnken Designs
Wheat is one of the most consumed foods in the world and unfortunately causes allergic reactions which have important health effects. The α-amylase/trypsin inhibitors (ATIs) have been identified as potentially allergen components of wheat. Due to a lack of data on optimization of ATI extraction, a new wheat ATIs extraction approach combining solvent extraction and selective precipitation is proposed in this work. Two types of wheat cultivars (Triticum aestivum L.), Julius and Ponticus were used and parameters such as solvent type, extraction time, temperature, stirring speed, salt type, salt concentration, buffer pH and centrifugation speed were analyzed using the Plackett-Burman design. Salt concentration, extraction time and pH appeared to have significant effects on the recovery of ATIs (p < 0.01). In both wheat cultivars, Julius and Ponticus, ammonium sulfate substantially reduced protein concentration and inhibition of amylase activity (IAA) compared to sodium chloride. The optimal conditions with desirability levels of 0.94 and 0.91 according to the Doehlert design were: salt concentrations of 1.67 and 1.22 M, extraction times of 53 and 118 min, and pHs of 7.1 and 7.9 for Julius and Ponticus, respectively. The corresponding responses were: protein concentrations of 0.31 and 0.35 mg and IAAs of 91.6 and 83.3%. Electrophoresis and MALDI-TOF/MS analysis showed that the extracted ATIs masses were between 10 and 20 kDa. Based on the initial LC-MS/MS analysis, up to 10 individual ATIs were identified in the extracted proteins under the optimal conditions. The positive implication of the present study lies in the quick assessment of their content in different varieties especially while considering their allergenic potential.
Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
10.25932/publishup-44222
urn:nbn:de:kobv:517-opus4-442229
1866-8372
molecules 24 (2019) 19, 3589 DOI: 10.3390/molecules24193589
3589
<a href="http://publishup.uni-potsdam.de/44221">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
CC-BY - Namensnennung 4.0 International
Sorel Sagu Tchewonpi
Gerd Huschek
Josephine Bönick
Thomas Homann
Harshadrai Manilal Rawel
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
805
eng
uncontrolled
wheat
eng
uncontrolled
α-amylase/trypsin inhibitors
eng
uncontrolled
extraction
eng
uncontrolled
Plackett–Burman design
eng
uncontrolled
Doehlert design
eng
uncontrolled
SDS-PAGE
eng
uncontrolled
MALDI-TOF/MS
eng
uncontrolled
LC-MS/MS
Chemie und zugeordnete Wissenschaften
open_access
Institut für Ernährungswissenschaft
Referiert
Open Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/44222/pmnr805.pdf
3927
1993
eng
postprint
0
2010-01-26
--
--
A new approach to the study of subitizing as distinct enumeration processing
This paper presents a new methodology for examining the phenomenon of subitizing. Subjects were presented with a standard numerosity-detection task but for a range of presentation times to allow Task-Accuracy Functions to be computed for individual subjects. The data appear to show a continuous change in processing for numerosities from 2 to 5 when the data are aggregated across subjects. At the level of individual subjects, there appear to be qualitative shifts in enumeration processing after 3 or 4 objects. The approach used in this experiment may be used to test the claim that subitizing is a distinct enumeration process that can be used for small numbers of objects.
urn:nbn:de:kobv:517-opus-41083
4108
Proceedings of the fifteenth annual conference of the Cognitive Science Society : June 18 to 21, 1993 ; Institute of Cognitive Science, University of Colorado-Boulder. - Hillsdale, NJ [u.a.] : Erlbaum, 1993, S. 929-934 ISBN 0-8058-1487-6
egger@...
Keine öffentliche Lizenz: Unter Urheberrechtsschutz
Tony Simon
Angel Cabrera
Reinhold Kliegl
Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe
paper 168
Psychologie
open_access
Department Psychologie
Institut für Psychologie
Universität Potsdam
https://publishup.uni-potsdam.de/files/3927/new_approach.pdf
9141
2016
eng
9
postprint
1
--
--
--
A New Figure of Merit for Organic Solar Cells with Transport-limited Photocurrents
Compared to their inorganic counterparts, organic semiconductors suffer from relatively low charge carrier mobilities. Therefore, expressions derived for inorganic solar cells to correlate characteristic performance parameters to material properties are prone to fail when applied to organic devices. This is especially true for the classical Shockley-equation commonly used to describe current-voltage (JV)-curves, as it assumes a high electrical conductivity of the charge transporting material. Here, an analytical expression for the JV-curves of organic solar cells is derived based on a previously published analytical model. This expression, bearing a similar functional dependence as the Shockley-equation, delivers a new figure of merit α to express the balance between free charge recombination and extraction in low mobility photoactive materials. This figure of merit is shown to determine critical device parameters such as the apparent series resistance and the fill factor.
urn:nbn:de:kobv:517-opus4-91414
online registration
Universität Potsdam, Publikationsfonds
PA 2016_16
1386.35
<a href="http://publishup.uni-potsdam.de/opus4-ubp/frontdoor/index/index/docId/9140">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
CC-BY - Namensnennung 4.0 International
Dieter Neher
Juliane Kniepert
Arik Elimelech
L. Jan Anton Koster
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
225
eng
uncontrolled
Electronic and spintronic devices
eng
uncontrolled
Semiconductors
Datenverarbeitung; Informatik
open_access
Institut für Physik und Astronomie
Referiert
Open Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/9141/pmnr225.pdf
57089
2022
2022
eng
2791
2805
15
1283
postprint
1
2022-12-09
2022-12-09
--
A new index to quantify the extremeness of precipitation across scales
Quantifying the extremeness of heavy precipitation allows for the comparison of events. Conventional quantitative indices, however, typically neglect the spatial extent or the duration, while both are important to understand potential impacts. In 2014, the weather extremity index (WEI) was suggested to quantify the extremeness of an event and to identify the spatial and temporal scale at which the event was most extreme. However, the WEI does not account for the fact that one event can be extreme at various spatial and temporal scales. To better understand and detect the compound nature of precipitation events, we suggest complementing the original WEI with a “cross-scale weather extremity index” (xWEI), which integrates extremeness over relevant scales instead of determining its maximum.
Based on a set of 101 extreme precipitation events in Germany, we outline and demonstrate the computation of both WEI and xWEI. We find that the choice of the index can lead to considerable differences in the assessment of past events but that the most extreme events are ranked consistently, independently of the index. Even then, the xWEI can reveal cross-scale properties which would otherwise remain hidden. This also applies to the disastrous event from July 2021, which clearly outranks all other analyzed events with regard to both WEI and xWEI.
While demonstrating the added value of xWEI, we also identify various methodological challenges along the required computational workflow: these include the parameter estimation for the extreme value distributions, the definition of maximum spatial extent and temporal duration, and the weighting of extremeness at different scales. These challenges, however, also represent opportunities to adjust the retrieval of WEI and xWEI to specific user requirements and application scenarios.
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
10.25932/publishup-57089
urn:nbn:de:kobv:517-opus4-570893
1866-8372
Voit, Paul
Version of record
<a href="http://publishup.uni-potsdam.de/57088">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
CC-BY - Namensnennung 4.0 International
Paul Voit
Maik Heistermann
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
1283
Geografie, Reisen
open_access
Referiert
Institut für Umweltwissenschaften und Geographie
Green Open-Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/57089/pmnr1283.pdf
51604
2020
2020
eng
12
1
postprint
1
2020-01-17
2020-01-17
--
A new lineage of segmented RNA viruses infecting animals
Metagenomic sequencing has revolutionised our knowledge of virus diversity, with new virus sequences being reported faster than ever before. However, virus discovery from metagenomic sequencing usually depends on detectable homology: without a sufficiently close relative, so-called ‘dark’ virus sequences remain unrecognisable. An alternative approach is to use virus-identification methods that do not depend on detecting homology, such as virus recognition by host antiviral immunity. For example, virus-derived small RNAs have previously been used to propose ‘dark’ virus sequences associated with the Drosophilidae (Diptera). Here, we combine published Drosophila data with a comprehensive search of transcriptomic sequences and selected meta-transcriptomic datasets to identify a completely new lineage of segmented positive-sense single-stranded RNA viruses that we provisionally refer to as the Quenyaviruses. Each of the five segments contains a single open reading frame, with most encoding proteins showing no detectable similarity to characterised viruses, and one sharing a small number of residues with the RNA-dependent RNA polymerases of single- and double-stranded RNA viruses. Using these sequences, we identify close relatives in approximately 20 arthropods, including insects, crustaceans, spiders, and a myriapod. Using a more conserved sequence from the putative polymerase, we further identify relatives in meta-transcriptomic datasets from gut, gill, and lung tissues of vertebrates, reflecting infections of vertebrates or of their associated parasites. Our data illustrate the utility of small RNAs to detect viruses with limited sequence conservation, and provide robust evidence for a new deeply divergent and phylogenetically distinct RNA virus lineage.
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
10.25932/publishup-51604
urn:nbn:de:kobv:517-opus4-516040
1866-8372
online registration
publish
<a href="http://publishup.uni-potsdam.de/61416">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
Virus Evolution, Volume 6, Issue 1, January 2020, vez061, https://doi.org/10.1093/ve/vez061
Version of Record
false
true
CC-BY - Namensnennung 4.0 International
Darren J. Obbard
Mang Shi
Katherine E. Roberts
Ben Longdon
Alice B. Dennis
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
1411
eng
uncontrolled
metagenome
eng
uncontrolled
RNA virus
eng
uncontrolled
dark virus
eng
uncontrolled
arthropod
eng
uncontrolled
RNA interference
Biowissenschaften; Biologie
Tiere (Zoologie)
open_access
Institut für Biochemie und Biologie
Referiert
Green Open-Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/51604/zmnr1411.pdf
42827
2019
2019
eng
8
705
postprint
1
2019-05-02
2019-05-02
--
A new reporter design based on DNA origami nanostructures
for quantification of short oligonucleotides using microbeads
The DNA origami technique has great potential for the development of brighter and more sensitive reporters for fluorescence based detection schemes such as a microbead-based assay in diagnostic applications. The nanostructures can be programmed to include multiple dye molecules to enhance the measured signal as well as multiple probe strands to increase the binding strength of the target oligonucleotide to these nanostructures. Here we present a proof-of-concept study to quantify short oligonucleotides by developing a novel DNA origami based reporter system, combined with planar microbead assays. Analysis of the assays using the VideoScan digital imaging platform showed DNA origami to be a more suitable reporter candidate for quantification of the target oligonucleotides at lower concentrations than a conventional reporter that consists of one dye molecule attached to a single stranded DNA. Efforts have been made to conduct multiplexed analysis of different targets as well as to enhance fluorescence signals obtained from the reporters. We therefore believe that the quantification of short oligonucleotides that exist in low copy numbers is achieved in a better way with the DNA origami nanostructures as reporters.
Postprints der Universität Potsdam : Mathematisch-naturwissenschaftliche Reihe
10.25932/publishup-42827
urn:nbn:de:kobv:517-opus4-428271
1866-8372
Scientific Reports 9 (2019) DOI:10.1038/s41598-019-41136-x
4769
<a href="http://publishup.uni-potsdam.de/opus4-ubp/frontdoor/index/index/docId/42821">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
CC-BY - Namensnennung 4.0 International
Youngeun Choi
Carsten Schmidt
Philip Tinnefeld
Ilko Bald
Stefan Rödiger
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
705
eng
uncontrolled
nucleic-acids
eng
uncontrolled
hybridization
eng
uncontrolled
microrna
eng
uncontrolled
flourescence
eng
uncontrolled
biomarkers
eng
uncontrolled
platform
eng
uncontrolled
particle
eng
uncontrolled
binding
eng
uncontrolled
array
eng
uncontrolled
gene
Naturwissenschaften und Mathematik
open_access
Mathematisch-Naturwissenschaftliche Fakultät
Referiert
Open Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/42827/pmnr705.pdf
52334
2021
2021
eng
17
20
postprint
1
2021-10-09
2021-09-07
--
A New Workflow to Generate Monoclonal Antibodies against Microorganisms
Monoclonal antibodies are used worldwide as highly potent and efficient detection reagents for research and diagnostic applications. Nevertheless, the specific targeting of complex antigens such as whole microorganisms remains a challenge. To provide a comprehensive workflow, we combined bioinformatic analyses with novel immunization and selection tools to design monoclonal antibodies for the detection of whole microorganisms. In our initial study, we used the human pathogenic strain E. coli O157:H7 as a model target and identified 53 potential protein candidates by using reverse vaccinology methodology. Five different peptide epitopes were selected for immunization using epitope-engineered viral proteins. The identification of antibody-producing hybridomas was performed by using a novel screening technology based on transgenic fusion cell lines. Using an artificial cell surface receptor expressed by all hybridomas, the desired antigen-specific cells can be sorted fast and efficiently out of the fusion cell pool. Selected antibody candidates were characterized and showed strong binding to the target strain E. coli O157:H7 with minor or no cross-reactivity to other relevant microorganisms such as Legionella pneumophila and Bacillus ssp. This approach could be useful as a highly efficient workflow for the generation of antibodies against microorganisms.
Mathematisch-Naturwissenschaftliche Reihe
10.25932/publishup-52334
urn:nbn:de:kobv:517-opus4-523341
1866-8372
<a href="http://publishup.uni-potsdam.de/52333">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
9359
Appl. Sci. 2021, 11(20), 9359; https://doi.org/10.3390/app11209359
true
true
CC-BY - Namensnennung 4.0 International
Markus Göthel
Martin Listek
Katrin Messerschmidt
Anja Schlör
Anja Hönow
Katja Hanack
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
1174
eng
uncontrolled
monoclonal antibody
eng
uncontrolled
antibody producing cell selection
eng
uncontrolled
hybridoma
eng
uncontrolled
epitope prediction
Biowissenschaften; Biologie
open_access
Institut für Biochemie und Biologie
Referiert
Green Open-Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/52334/pmnr1174.pdf
45989
2020
2020
eng
14
865
postprint
1
2020-04-07
2020-04-07
--
A novel selection strategy for antibody producing hybridoma cells based on a new transgenic fusion cell line
The use of monoclonal antibodies is ubiquitous in science and biomedicine but the generation and validation process of antibodies is nevertheless complicated and time-consuming. To address these issues we developed a novel selective technology based on an artificial cell surface construct by which secreted antibodies were connected to the corresponding hybridoma cell when they possess the desired antigen-specificity. Further the system enables the selection of desired isotypes and the screening for potential cross-reactivities in the same context. For the design of the construct we combined the transmembrane domain of the EGF-receptor with a hemagglutinin epitope and a biotin acceptor peptide and performed a transposon-mediated transfection of myeloma cell lines. The stably transfected myeloma cell line was used for the generation of hybridoma cells and an antigen- and isotype-specific screening method was established. The system has been validated for globular protein antigens as well as for haptens and enables a fast and early stage selection and validation of monoclonal antibodies in one step.
Postprints der Universität Potsdam : Mathematisch Naturwissenschaftliche Reihe
10.25932/publishup-45989
urn:nbn:de:kobv:517-opus4-459893
1866-8372
Scientific Reports 10 (2020) 1664 DOI:10.1038/s41598-020-58571-w
<a href="http://publishup.uni-potsdam.de/45990">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
1664
CC-BY - Namensnennung 4.0 International
Martin Listek
Anja Hönow
Manfred Gossen
Katja Hanack
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
865
eng
uncontrolled
Antibody generation
eng
uncontrolled
Assay systems
Naturwissenschaften und Mathematik
Technik, Technologie
open_access
Mathematisch-Naturwissenschaftliche Fakultät
Referiert
Open Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/45989/pmnr865.pdf
46973
2019
2021
eng
13
688
postprint
1
2021-01-08
2021-01-08
--
A path to the bilingual advantage
Matching participants (as suggested by Hope, 2015) may be one promising option for research on a potential bilingual advantage in executive functions (EF). In this study we first compared performances in three EF-tasks of a naturally heterogeneous sample of monolingual (n = 69, age = 9.0 y) and multilingual children (n = 57, age = 9.3 y). Secondly, we meticulously matched participants pairwise to obtain two highly homogeneous groups to rerun our analysis and investigate a potential bilingual advantage. The initally disadvantaged multilinguals (regarding socioeconomic status and German lexicon size) performed worse in updating and response inhibition, but similarly in interference inhibition. This indicates that superior EF compensate for the detrimental effects of the background variables. After matching children pairwise on age, gender, intelligence, socioeconomic status and German lexicon size, performances became similar except for interference inhibition. Here, an advantage for multilinguals in the form of globally reduced reaction times emerged, indicating a bilingual executive processing advantage.
Postprints der Universität Potsdam : Humanwissenschaftliche Reihe
pairwise matching of individuals
10.25932/publishup-46973
urn:nbn:de:kobv:517-opus4-469736
1866-8364
online registration
Bilingualism: Language and Cognition 23(2020) 2 , 344 - 354; DOI: 10.1017/S1366728919000166
<a href="https://publishup.uni-potsdam.de/57757">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
CC-BY - Namensnennung 4.0 International
Sophia Czapka
Christiane Wotschack
Annegret Klassert
Julia Festman
Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe
688
eng
uncontrolled
executive functions
eng
uncontrolled
bilingualism
eng
uncontrolled
interference inhibition
eng
uncontrolled
pairwise matching
eng
uncontrolled
primary school children
eng
uncontrolled
background variables
eng
uncontrolled
lexicon size
Sprache
open_access
Referiert
Department Linguistik
Cambridge University Press (CUP)
Green Open-Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/46973/phr688.pdf
54888
2021
2022
eng
1
8
8
postprint
Universitätsverlag Potsdam
Potsdam
1
2022-04-29
2022-04-29
--
A phylogeny of the genus Limia (Teleostei: Poeciliidae) suggests a single-lake radiation nested in a Caribbean-wide allopatric speciation scenario
Objective
The Caribbean is an important global biodiversity hotspot. Adaptive radiations there lead to many speciation events within a limited period and hence are particularly prominent biodiversity generators. A prime example are freshwater fish of the genus Limia, endemic to the Greater Antilles. Within Hispaniola, nine species have been described from a single isolated site, Lake Miragoâne, pointing towards extraordinary sympatric speciation. This study examines the evolutionary history of the Limia species in Lake Miragoâne, relative to their congeners throughout the Caribbean.
Results
For 12 Limia species, we obtained almost complete sequences of the mitochondrial cytochrome b gene, a well-established marker for lower-level taxonomic relationships. We included sequences of six further Limia species from GenBank (total N = 18 species). Our phylogenies are in concordance with other published phylogenies of Limia. There is strong support that the species found in Lake Miragoâne in Haiti are monophyletic, confirming a recent local radiation. Within Lake Miragoâne, speciation is likely extremely recent, leading to incomplete lineage sorting in the mtDNA. Future studies using multiple unlinked genetic markers are needed to disentangle the relationships within the Lake Miragoâne clade.
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
10.25932/publishup-54888
urn:nbn:de:kobv:517-opus4-548882
1866-8372
Version of record
Tiedemann, Ralph
<a href="http://publishup.uni-potsdam.de/opus4-ubp/frontdoor/index/index/docId/54887">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
CC-BY - Namensnennung 4.0 International
Montrai Spikes
Rodet Rodríguez-Silva
Kerri-Ann Bennett
Stefan Bräger
James Josaphat
Patricia Torres-Pineda
Anja Ernst
Katja Havenstein
Ingo Schlupp
Ralph Tiedemann
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
1238
eng
uncontrolled
Cytochrome b
eng
uncontrolled
Island biogeography
eng
uncontrolled
Fresh water fish
eng
uncontrolled
Phylogeny
Biowissenschaften; Biologie
open_access
Institut für Biochemie und Biologie
Green Open-Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/54888/pmnr1238.pdf
42759
2008
2020
eng
13
830
postprint
1
2020-03-04
2020-03-04
--
A plant resource and experiment management system based on the Golm Plant Database as a basic tool for omics research
Background: For omics experiments, detailed characterisation of experimental material with respect to its genetic features, its cultivation history and its treatment history is a requirement for analyses by bioinformatics tools and for publication needs. Furthermore, meta-analysis of several experiments in systems biology based approaches make it necessary to store this information in a standardised manner, preferentially in relational databases. In the Golm Plant Database System, we devised a data management system based on a classical Laboratory Information Management System combined with web-based user interfaces for data entry and retrieval to collect this information in an academic environment.
Results: The database system contains modules representing the genetic features of the germplasm, the experimental conditions and the sampling details. In the germplasm module, genetically identical lines of biological material are generated by defined workflows, starting with the import workflow, followed by further workflows like genetic modification (transformation), vegetative or sexual reproduction. The latter workflows link lines and thus create pedigrees. For experiments, plant objects are generated from plant lines and united in so-called cultures, to which the cultivation conditions are linked. Materials and methods for each cultivation step are stored in a separate ACCESS database of the plant cultivation unit. For all cultures and thus every plant object, each cultivation site and the culture's arrival time at a site are logged by a barcode-scanner based system. Thus, for each plant object, all site-related parameters, e. g. automatically logged climate data, are available. These life history data and genetic information for the plant objects are linked to analytical results by the sampling module, which links sample components to plant object identifiers. This workflow uses controlled vocabulary for organs and treatments. Unique names generated by the system and barcode labels facilitate identification and management of the material. Web pages are provided as user interfaces to facilitate maintaining the system in an environment with many desktop computers and a rapidly changing user community. Web based search tools are the basis for joint use of the material by all researchers of the institute.
Conclusion: The Golm Plant Database system, which is based on a relational database, collects the genetic and environmental information on plant material during its production or experimental use at the Max-Planck-Institute of Molecular Plant Physiology. It thus provides information according to the MIAME standard for the component 'Sample' in a highly standardised format. The Plant Database system thus facilitates collaborative work and allows efficient queries in data analysis for systems biology research.
Postprints der Universität Potsdam : Mathematisch Naturwissenschaftliche Reihe
10.25932/publishup-42759
urn:nbn:de:kobv:517-opus4-427595
Plant Methods 4 (2008) 11 DOI: 10.1186/1746-4811-4-11
true
true
Karin I. Köhl
Georg Basler
Alexander Lüdemann
Joachim Selbig
Dirk Walther
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
830
eng
uncontrolled
microarray data
eng
uncontrolled
arabidopsis
eng
uncontrolled
information
Biowissenschaften; Biologie
Pflanzen (Botanik)
open_access
Mathematisch-Naturwissenschaftliche Fakultät
Referiert
Open Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/42759/pmnr830.pdf
9511
2013
2013
eng
1848
1856
postprint
1
--
2013-01-07
--
A polymer analogous reaction for the formation of imidazolium and NHC based porous polymer networks
A polymer analogous reaction was carried out to generate a porous polymeric network with N-heterocyclic carbenes (NHC) in the polymer backbone. Using a stepwise approach, first a polyimine network is formed by polymerization of the tetrafunctional amine tetrakis(4-aminophenyl)methane. This polyimine network is converted in the second step into polyimidazolium chloride and finally to a polyNHC network. Furthermore a porous Cu(II)-coordinated polyNHC network can be generated. Supercritical drying generates polymer networks with high permanent surface areas and porosities which can be applied for different catalytic reactions. The catalytic properties were demonstrated for example in the activation of CO2 or in the deoxygenation of sulfoxides to the corresponding sulfides.
urn:nbn:de:kobv:517-opus4-95118
online registration
Polym. Chem. (2013) Nr. 4, S. 1848-1856. - DOI: 10.1039/C2PY20947K
Keine öffentliche Lizenz: Unter Urheberrechtsschutz
Kerstin Thiel
Rolf Zehbe
Jerômé Roeser
Peter Strauch
Stephan Enthaler
Arne Thomas
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
243
eng
uncontrolled
covalent organic framework
eng
uncontrolled
n-heterocyclic carbenes
eng
uncontrolled
carbon-dioxide
eng
uncontrolled
intrinsic microporosity
eng
uncontrolled
heterogeneous catalysis
eng
uncontrolled
sulfoxides
eng
uncontrolled
reduction
eng
uncontrolled
complex
eng
uncontrolled
system
eng
uncontrolled
transformation
Chemie und zugeordnete Wissenschaften
open_access
Institut für Chemie
Referiert
Open Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/9511/pmnr243_online.pdf
43421
2019
2019
eng
968
993
27
165
postprint
1
2019-10-28
2019-10-28
--
A predisposition to brutality?
The German Sonderweg thesis has been discarded in most research fields. Yet in regards to the military, things differ: all conflicts before the Second World War are interpreted as prelude to the war of extermination between 1939–1945. This article specifically looks at the Franco-Prussian War 1870–71 and German behaviour vis-à-vis regular combatants, civilians and irregular guerrilla fighters, the so-called francs-tireurs. The author argues that the counter-measures were not exceptional for nineteenth century warfare and also shows how selective reading of the existing secondary literature has distorted our view on the war.
Postprints der Universität Potsdam Philosophische Reihe
german practices against civilians and francs-tireurs during the Franco-Prussian war 1870–1871 and their relevance for the German ‘military Sonderweg’ debate
urn:nbn:de:kobv:517-opus4-434218
10.25932/publishup-43421
1866-8380
online registration
Small Wars & Insurgencies 30 (2019) 4–5, S. 968–993 DOI: 10.1080/09592318.2019.1638551
<a href="http://publishup.uni-potsdam.de/48766">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
CC-BY-NC-ND - Namensnennung, nicht kommerziell, keine Bearbeitungen 4.0 International
Bastian Matteo Scianna
Zweitveröffentlichungen der Universität Potsdam : Philosophische Reihe
165
eng
uncontrolled
francs-tireurs
eng
uncontrolled
levee en masse
eng
uncontrolled
myth of Franktireurkrieg
eng
uncontrolled
Franco-Prussian War
eng
uncontrolled
Geneva convention of 1864
deu
uncontrolled
Landwehr
eng
uncontrolled
siege of Paris 1870
Politikwissenschaft
open_access
Philosophische Fakultät
Referiert
Open Access
Taylor & Francis Open Access Agreement
Universität Potsdam
https://publishup.uni-potsdam.de/files/43421/ppr165.pdf
40799
2014
2018
eng
1813
1831
19
487
postprint
1
2018-12-21
2018-12-21
--
A probabilistic risk assessment for the vulnerability of the European carbon cycle to weather extremes
Extreme weather events are likely to occur more often under climate change and the resulting effects on ecosystems could lead to a further acceleration of climate change. But not all extreme weather events lead to extreme ecosystem response. Here, we focus on hazardous ecosystem behaviour and identify coinciding weather conditions. We use a simple probabilistic risk assessment based on time series of ecosystem behaviour and climate conditions. Given the risk assessment terminology, vulnerability and risk for the previously defined hazard are estimated on the basis of observed hazardous ecosystem behaviour.
We apply this approach to extreme responses of terrestrial ecosystems to drought, defining the hazard as a negative net biome productivity over a 12-month period. We show an application for two selected sites using data for 1981-2010 and then apply the method to the pan-European scale for the same period, based on numerical modelling results (LPJmL for ecosystem behaviour; ERA-Interim data for climate).
Our site-specific results demonstrate the applicability of the proposed method, using the SPEI to describe the climate condition. The site in Spain provides an example of vulnerability to drought because the expected value of the SPEI is 0.4 lower for hazardous than for non-hazardous ecosystem behaviour. In northern Germany, on the contrary, the site is not vulnerable to drought because the SPEI expectation values imply wetter conditions in the hazard case than in the non-hazard case.
At the pan-European scale, ecosystem vulnerability to drought is calculated in the Mediterranean and temperate region, whereas Scandinavian ecosystems are vulnerable under conditions without water shortages. These first model- based applications indicate the conceptual advantages of the proposed method by focusing on the identification of critical weather conditions for which we observe hazardous ecosystem behaviour in the analysed data set. Application of the method to empirical time series and to future climate would be important next steps to test the approach.
Postprints der Universität Potsdam : Mathematisch naturwissenschaftliche Reihe (487)
The ecosystem perspective
urn:nbn:de:kobv:517-opus4-407999
1866-8372
online registration
Biogeosciences 12 (2015) 6, pp. 1813-1831 DOI 10.5194/bg-12-1813-2015
CC-BY - Namensnennung 4.0 International
Susanne Rolinski
Anja Rammig
Ariane Walz
Werner von Bloh
M. van Oijen
Kirsten Thonicke
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
487
eng
uncontrolled
global vegetation model
eng
uncontrolled
climate extremes
eng
uncontrolled
fire emissions
eng
uncontrolled
drought
eng
uncontrolled
forest
eng
uncontrolled
productivity
eng
uncontrolled
reduction
eng
uncontrolled
events
eng
uncontrolled
assimilation
eng
uncontrolled
uncertainty
Geowissenschaften
Biowissenschaften; Biologie
open_access
Institut für Geowissenschaften
Referiert
Open Access
Copernicus
Institut für Erd- und Umweltwissenschaften
Universität Potsdam
Universität Potsdam
https://publishup.uni-potsdam.de/files/40799/pmnr487.pdf
54995
2021
2022
eng
1
13
13
21
postprint
Universitätsverlag Potsdam
Potsdam
1
2022-05-19
2022-05-19
--
A prospective investigation of developmental trajectories of psychosocial adjustment in adolescents facing a chronic condition - study protocol of an observational, multi-center study
Background
Relatively little is known about protective factors and the emergence and maintenance of positive outcomes in the field of adolescents with chronic conditions. Therefore, the primary aim of the study is to acquire a deeper understanding of the dynamic process of resilience factors, coping strategies and psychosocial adjustment of adolescents living with chronic conditions.
Methods/design
We plan to consecutively recruit N = 450 adolescents (12–21 years) from three German patient registries for chronic conditions (type 1 diabetes, cystic fibrosis, or juvenile idiopathic arthritis). Based on screening for anxiety and depression, adolescents are assigned to two parallel groups – “inconspicuous” (PHQ-9 and GAD-7 < 7) vs. “conspicuous” (PHQ-9 or GAD-7 ≥ 7) – participating in a prospective online survey at baseline and 12-month follow-up. At two time points (T1, T2), we assess (1) intra- and interpersonal resiliency factors, (2) coping strategies, and (3) health-related quality of life, well-being, satisfaction with life, anxiety and depression. Using a cross-lagged panel design, we will examine the bidirectional longitudinal relations between resiliency factors and coping strategies, psychological adaptation, and psychosocial adjustment. To monitor Covid-19 pandemic effects, participants are also invited to take part in an intermediate online survey.
Discussion
The study will provide a deeper understanding of adaptive, potentially modifiable processes and will therefore help to develop novel, tailored interventions supporting a positive adaptation in youths with a chronic condition. These strategies should not only support those at risk but also promote the maintenance of a successful adaptation.
Trial registration
German Clinical Trials Register (DRKS), no. DRKS00025125. Registered on May 17, 2021.
Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe
10.25932/publishup-54995
urn:nbn:de:kobv:517-opus4-549951
1866-8364
404 (2021)
Warschburger, Petra
Version of record
<a href="http://publishup.uni-potsdam.de/opus4-ubp/frontdoor/index/index/docId/54994">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
CC-BY - Namensnennung 4.0 International
Petra Warschburger
Ann-Christin Petersen
Roman Enzio von Rezori
Friederike Buchallik
Harald Baumeister
Reinhard Holl
Kirsten Minden
Annabel Sandra Müller-Stierlin
Christina Reinauer
Doris Staab
COACH consortium
Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe
762
eng
uncontrolled
Chronic conditions
eng
uncontrolled
Adolescents
eng
uncontrolled
Prospective
eng
uncontrolled
Quality of life
eng
uncontrolled
Resiliency
eng
uncontrolled
Coping
eng
uncontrolled
Protective factors
eng
uncontrolled
Type 1 diabetes
eng
uncontrolled
Juvenile idiopathic arthritis
eng
uncontrolled
Cystic fibrosis
open_access
Strukturbereich Kognitionswissenschaften
Referiert
Green Open-Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/54995/phr762.pdf
4281
2006
2006
eng
postprint
1
2010-07-15
--
--
A review of neurohormone GPCRs present in the fruitfly Drosophila melanogaster and the honey bee Apis mellifera
G protein-coupled receptor (GPCR) genes are large gene families in every animal, sometimes making up to 1-2% of the animal's genome. Of all insect GPCRs, the neurohormone (neuropeptide, protein hormone, biogenic amine) GPCRs are especially important, because they, together with their ligands, occupy a high hierarchic position in the physiology of insects and steer crucial processes such as development, reproduction, and behavior. In this paper, we give a review of our current knowledge on Drosophila melanogaster GPCRs and use this information to annotate the neurohormone GPCR genes present in the recently sequenced genome from the honey bee Apis mellifera. We found 35 neuropeptide receptor genes in the honey bee (44 in Drosophila) and two genes, coding for leucine-rich repeats-containing protein hormone GPCRs (4 in Drosophila). In addition, the honey bee has 19 biogenic amine receptor genes (21 in Drosophila). The larger numbers of neurohormone receptors in Drosophila are probably due to gene duplications that occurred during recent evolution of the fly. Our analyses also yielded the likely ligands for 40 of the 56 honey bee neurohormone GPCRs identified in this study. In addition, we made some interesting observations on neurohormone GPCR evolution and the evolution and co-evolution of their ligands. For neuropeptide and protein hormone GPCRs, there appears to be a general co-evolution between receptors and their ligands. This is in contrast to biogenic amine GPCRs, where evolutionarily unrelated GPCRs often bind to the same biogenic amine, suggesting frequent ligand exchanges ("ligand hops") during GPCR evolution. (c) 2006 Elsevier Ltd. All rights reserved.
urn:nbn:de:kobv:517-opus-44326
4432
Progress in neurobiology 80 (2006), 1, S. 1 - 19, DOI: 10.1016/j.pneurobio.2006.07.005
<hr>The article was originally published by:<br><a href="http://www.elsevier.com/wps/find/journaldescription.cws_home/622287/descript">Elsevier</a><br><a href="http://www.sciencedirect.com/science/journal/03010082">Progress in neurobiology</a>. - 80 (2006), 1, S. 1-19<br>ISSN 0301-0082<br>DOI <a href="http://dx.doi.org/10.1016/j.pneurobio.2006.07.005"> 10.1016/j.pneurobio.2006.07.005</a>
Keine öffentliche Lizenz: Unter Urheberrechtsschutz
Wolfgang Blenau
Frank Hauser
Giuseppe Cazzamali
Michael Williamson
Cornelis J. P. Grimmelikhuijzen
eng
uncontrolled
GPCR
eng
uncontrolled
neuropeptide
eng
uncontrolled
neurohormone
eng
uncontrolled
hormone
eng
uncontrolled
biogenic amine
Biowissenschaften; Biologie
open_access
Institut für Biochemie und Biologie
Universität Potsdam
https://publishup.uni-potsdam.de/files/4281/review_of_neurohormone.pdf
43493
2019
2019
eng
9
739
postprint
1
2019-09-18
1019-09-18
--
A Salinity Threshold Separating Fungal Communities in the Baltic Sea
Salinity is a significant factor for structuring microbial communities, but little is known for aquatic fungi, particularly in the pelagic zone of brackish ecosystems. In this study, we explored the diversity and composition of fungal communities following a progressive salinity decline (from 34 to 3 PSU) along three transects of ca. 2000 km in the Baltic Sea, the world’s largest estuary. Based on 18S rRNA gene sequence analysis, we detected clear changes in fungal community composition along the salinity gradient and found significant differences in composition of fungal communities established above and below a critical value of 8 PSU. At salinities below this threshold, fungal communities resembled those from freshwater environments, with a greater abundance of Chytridiomycota, particularly of the orders Rhizophydiales, Lobulomycetales, and
Gromochytriales. At salinities above 8 PSU, communities were more similar to those from marine environments and, depending on the season, were dominated by a strain of the LKM11 group (Cryptomycota) or by members of Ascomycota and Basidiomycota. Our results highlight salinity as an important environmental driver also for pelagic fungi, and thus should be taken into account to better understand fungal diversity and ecological function in the aquatic realm.
Postprints der Universität Potsdam Mathematisch-Naturwissenschaftliche Reihe
10.25932/publishup-43493
urn:nbn:de:kobv:517-opus4-434937
1866-8372
680
<a href="http://publishup.uni-potsdam.de/opus4-ubp/frontdoor/index/index/docId/43492">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
false
true
CC-BY - Namensnennung 4.0 International
Keilor Rojas-Jimenez
Angelika Rieck
Christian Wurzbacher
Klaus Jürgens
Matthias Labrenz
Hans-Peter Grossart
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
739
eng
uncontrolled
fungal diversity
eng
uncontrolled
baltic sea
eng
uncontrolled
salinity gradient
eng
uncontrolled
brackish waters
eng
uncontrolled
chytridiomycota
eng
uncontrolled
cryptomycota
Biowissenschaften; Biologie
open_access
Institut für Biochemie und Biologie
Referiert
Open Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/43493/pmnr739.pdf
52383
2019
2019
eng
16
726
postprint
1
2019-11-22
2019-07-20
--
A seamless filter for daily to seasonal forecasts, with applications to Iran and Brazil
A digital filter is introduced which treats the problem of predictability versus time averaging in a continuous, seamless manner. This seamless filter (SF) is characterized by a unique smoothing rule that determines the strength of smoothing in dependence on lead time. The rule needs to be specified beforehand, either by expert knowledge or by user demand. As a result, skill curves are obtained that allow a predictability assessment across a whole range of time-scales, from daily to seasonal, in a uniform manner. The SF is applied to downscaled SEAS5 ensemble forecasts for two focus regions in or near the tropical belt, the river basins of the Karun in Iran and the Sao Francisco in Brazil. Both are characterized by strong seasonality and semi-aridity, so that predictability across various time-scales is in high demand. Among other things, it is found that from the start of the water year (autumn), areal precipitation is predictable with good skill for the Karun basin two and a half months ahead; for the Sao Francisco it is only one month, longer-term prediction skill is just above the critical level.
Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
10.25932/publishup-52383
urn:nbn:de:kobv:517-opus4-523835
1866-8372
<a href="http://publishup.uni-potsdam.de/52747">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
Version of records
Q J R Meteorol Soc. 2020; 146: 240– 253. https://doi.org/10.1002/qj.3670
true
true
CC-BY - Namensnennung 4.0 International
Gerd Bürger
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
1214
eng
uncontrolled
climate drift
eng
uncontrolled
ensemble prediction
eng
uncontrolled
seamless prediction
eng
uncontrolled
seasonal forecast skill
Geowissenschaften
open_access
Referiert
Institut für Umweltwissenschaften und Geographie
Green Open-Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/52383/pmnr1214.pdf
40374
2017
2017
eng
17
postprint
1
--
2017-11-16
--
A self-avoiding walk with neural delays as a model of fixational eye movements
Fixational eye movements show scaling behaviour of the positional mean-squared displacement with a characteristic transition from persistence to antipersistence for increasing time-lag. These statistical patterns were found to be mainly shaped by microsaccades (fast, small-amplitude movements). However, our re-analysis of fixational eye-movement data provides evidence that the slow component (physiological drift) of the eyes exhibits scaling behaviour of the mean-squared displacement that varies across human participants. These results suggest that drift is a correlated movement that interacts with microsaccades. Moreover, on the long time scale, the mean-squared displacement of the drift shows oscillations, which is also present in the displacement auto-correlation function. This finding lends support to the presence of time-delayed feedback in the control of drift movements. Based on an earlier non-linear delayed feedback model of fixational eye movements, we propose and discuss different versions of a new model that combines a self-avoiding walk with time delay. As a result, we identify a model that reproduces oscillatory correlation functions, the transition from persistence to antipersistence, and microsaccades.
urn:nbn:de:kobv:517-opus4-403742
online registration
Scientific reports 7 (2017). - DOI: 10.1038/s41598-017-13489-8
<a href="http://publishup.uni-potsdam.de/opus4-ubp/frontdoor/index/index/docId/40373">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
CC-BY - Namensnennung 4.0 International
Carl J. J. Herrmann
Ralf Metzler
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
392
Informatik, Informationswissenschaft, allgemeine Werke
Physik
open_access
Institut für Physik und Astronomie
Referiert
Open Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/40374/pmnr392_online.pdf
41665
2017
2017
eng
109
118
10
604
postprint
1
2019-02-14
2019-02-14
--
A simple calculation algorithm to separate high-resolution CH4 flux measurements into ebullition- and diffusion-derived components
Processes driving the production, transformation and transport of methane (CH4) in wetland ecosystems are highly complex. We present a simple calculation algorithm to separate open-water CH4 fluxes measured with automatic chambers into diffusion- and ebullition-derived components. This helps to reveal underlying dynamics, to identify potential environmental drivers and, thus, to calculate reliable CH4 emission estimates. The flux separation is based on identification of ebullition-related sudden concentration changes during single measurements. Therefore, a variable ebullition filter is applied, using the lower and upper quartile and the interquartile range (IQR). Automation of data processing is achieved by using an established R script, adjusted for the purpose of CH4 flux calculation. The algorithm was validated by performing a laboratory experiment and tested using flux measurement data (July to September 2013) from a former fen grassland site, which converted into a shallow lake as a result of rewetting. Ebullition and diffusion contributed equally (46 and 55 %) to total CH4 emissions, which is comparable to ratios given in the literature. Moreover, the separation algorithm revealed a concealed shift in the diurnal trend of diffusive fluxes throughout the measurement period. The water temperature gradient was identified as one of the major drivers of diffusive CH4 emissions, whereas no significant driver was found in the case of erratic CH4 ebullition events.
Postprints der Universität Potsdam : Mathematisch Naturwissenschaftliche Reihe
10.25932/publishup-41665
urn:nbn:de:kobv:517-opus4-416659
1866-8372
online registration
Atmospheric Measurement Techniques 10 (2017) 1, pp. 109–118 DOI 10.5194/amt-10-109-2017
<a href="http://publishup.uni-potsdam.de/55531">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
CC-BY - Namensnennung 4.0 International
Mathias Hoffmann
Maximilian Schulz-Hanke
Juana Garcia Alba
Nicole Jurisch
Ulrike Hagemann
Torsten Sachs
Michael Sommer
Jürgen Augustin
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
604
eng
uncontrolled
water methane emissions
eng
uncontrolled
chamber system
eng
uncontrolled
CO2
eng
uncontrolled
lake
eng
uncontrolled
fen
eng
uncontrolled
exchange
eng
uncontrolled
mechanism
eng
uncontrolled
turbulence
eng
uncontrolled
transport
eng
uncontrolled
reservior
Geowissenschaften
open_access
Mathematisch-Naturwissenschaftliche Fakultät
Referiert
Open Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/41665/pmnr604.pdf
40983
2016
2019
eng
9
529
postprint
1
2019-01-18
2019-01-18
--
A simple equation for the melt elevation feedback of ice sheets
In recent decades, the Greenland Ice Sheet has been losing mass and has thereby contributed to global sea-level rise. The rate of ice loss is highly relevant for coastal protection worldwide. The ice loss is likely to increase under future warming. Beyond a critical temperature threshold, a meltdown of the Greenland Ice Sheet is induced by the self-enforcing feedback between its lowering surface elevation and its increasing surface mass loss: the more ice that is lost, the lower the ice surface and the warmer the surface air temperature, which fosters further melting and ice loss. The computation of this rate so far relies on complex numerical models which are the appropriate tools for capturing the complexity of the problem. By contrast we aim here at gaining a conceptual understanding by deriving a purposefully simple equation for the self-enforcing feedback which is then used to estimate the melt time for different levels of warming using three observable characteristics of the ice sheet itself and its surroundings. The analysis is purely conceptual in nature. It is missing important processes like ice dynamics for it to be useful for applications to sea-level rise on centennial timescales, but if the volume loss is dominated by the feedback, the resulting logarithmic equation unifies existing numerical simulations and shows that the melt time depends strongly on the level of warming with a critical slow-down near the threshold: the median time to lose 10% of the present-day ice volume varies between about 3500 years for a temperature level of 0.5 degrees C above the threshold and 500 years for 5 degrees C. Unless future observations show a significantly higher melting sensitivity than currently observed, a complete meltdown is unlikely within the next 2000 years without significant ice-dynamical contributions.
Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
10.25932/publishup-40983
urn:nbn:de:kobv:517-opus4-409834
1866-8372
online registration
The Cryosphere 10 (2016), pp. 1799–1807 DOI 10.5194/tc-10-1799-2016
CC-BY - Namensnennung 4.0 International
Anders Levermann
Hilke Ricarda Winkelmann
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
529
eng
uncontrolled
sea-level rise
eng
uncontrolled
mass-balance
eng
uncontrolled
climate-change
eng
uncontrolled
Greenland
eng
uncontrolled
model
eng
uncontrolled
glacier
eng
uncontrolled
projections
eng
uncontrolled
dynamics
eng
uncontrolled
impact
eng
uncontrolled
21st-Century
Geografie, Reisen
open_access
Mathematisch-Naturwissenschaftliche Fakultät
Referiert
Open Access
Copernicus
Universität Potsdam
https://publishup.uni-potsdam.de/files/40983/pmnr529.pdf
43874
2019
2019
eng
23633
23641
9
769
postprint
1
2019-11-21
2019-11-21
--
A simple one-step procedure to synthesise gold nanostars in concentrated aqueous surfactant solutions
Due to the enhanced electromagnetic field at the tips of metal nanoparticles, the spiked structure of gold nanostars (AuNSs) is promising for surface-enhanced Raman scattering (SERS). Therefore, the challenge is the synthesis of well designed particles with sharp tips. The influence of different surfactants, i.e., dioctyl sodium sulfosuccinate (AOT), sodium dodecyl sulfate (SDS), and benzylhexadecyldimethylammonium chloride (BDAC), as well as the combination of surfactant mixtures on the formation of nanostars in the presence of Ag⁺ ions and ascorbic acid was investigated. By varying the amount of BDAC in mixed micelles the core/spike-shell morphology of the resulting AuNSs can be tuned from small cores to large ones with sharp and large spikes. The concomitant red-shift in the absorption toward the NIR region without losing the SERS enhancement enables their use for biological applications and for time-resolved spectroscopic studies of chemical reactions, which require a permanent supply with a fresh and homogeneous solution. HRTEM micrographs and energy-dispersive X-ray (EDX) experiments allow us to verify the mechanism of nanostar formation according to the silver underpotential deposition on the spike surface in combination with micelle adsorption.
Postprints der Universität Potsdam Mathematisch-Naturwissenschaftliche Reihe
10.25932/publishup-43874
urn:nbn:de:kobv:517-opus4-438743
1866-8372
RSC Advances 9 (2019), S. 23633–23641 DOI: 10.1039/C9RA02384D
<a href="http://publishup.uni-potsdam.de/43873">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
Ferenc Liebig
Ricky Henning
Radwan Mohamed Sarhan
Claudia Christina Prietzel
Clemens Nikolaus Zeno Schmitt
Matias Bargheer
Joachim Koetz
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
769
eng
uncontrolled
optical-properties
eng
uncontrolled
nanoparticles
eng
uncontrolled
sers
eng
uncontrolled
ultrafast
eng
uncontrolled
size
eng
uncontrolled
nanotriangles
eng
uncontrolled
nanoflowers
eng
uncontrolled
wavelength
Chemie und zugeordnete Wissenschaften
open_access
Institut für Chemie
Referiert
Open Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/43874/pmnr769.pdf
40007
2017
eng
13
postprint
1
--
2017-08-31
--
A single nucleotide polymorphism near the CYP17A1 gene is associated with left ventricular mass in hypertensive patients under pharmacotherapy
Cytochrome P450 17A1 (CYP17A1) catalyses the formation and metabolism of steroid hormones. They are involved in blood pressure (BP) regulation and in the pathogenesis of left ventricular hypertrophy. Therefore, altered function of CYP17A1 due to genetic variants may influence BP and left ventricular mass. Notably, genome wide association studies supported the role of this enzyme in BP control. Against this background, we investigated associations between single nucleotide polymorphisms (SNPs) in or nearby the CYP17A1 gene with BP and left ventricular mass in patients with arterial hypertension and associated cardiovascular organ damage treated according to guidelines. Patients (n = 1007, mean age 58.0 ± 9.8 years, 83% men) with arterial hypertension and cardiac left ventricular ejection fraction (LVEF) ≥40% were enrolled in the study. Cardiac parameters of left ventricular mass, geometry and function were determined by echocardiography. The cohort comprised patients with coronary heart disease (n = 823; 81.7%) and myocardial infarction (n = 545; 54.1%) with a mean LVEF of 59.9% ± 9.3%. The mean left ventricular mass index (LVMI) was 52.1 ± 21.2 g/m2.7 and 485 (48.2%) patients had left ventricular hypertrophy. There was no significant association of any investigated SNP (rs619824, rs743572, rs1004467, rs11191548, rs17115100) with mean 24 h systolic or diastolic BP. However, carriers of the rs11191548 C allele demonstrated a 7% increase in LVMI (95% CI: 1%–12%, p = 0.017) compared to non-carriers. The CYP17A1 polymorphism rs11191548 demonstrated a significant association with LVMI in patients with arterial hypertension and preserved LVEF. Thus, CYP17A1 may contribute to cardiac hypertrophy in this clinical condition.
urn:nbn:de:kobv:517-opus4-400074
online registration
International journal of molecular sciences 6 (2015) Nr. 8, S. 17456–17468. - DOI: 10.3390/ijms160817456
CC-BY - Namensnennung 4.0 International
Matthias Huber
Susanne Lezius
Rona Katharina Reibis
Andras Treszl
Dorota Kujawinska
Stefanie Jakob
Karl Wegscheider
Heinz Völler
Reinhold Kreutz
Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe
333
eng
uncontrolled
clinical study
eng
uncontrolled
genetics
eng
uncontrolled
heart
eng
uncontrolled
hypertension
eng
uncontrolled
cytochrome P450 17A1 (Cyp17A1)
Chemie und zugeordnete Wissenschaften
Biowissenschaften; Biologie
open_access
Humanwissenschaftliche Fakultät
Referiert
Open Access
Multidisciplinary Digital Publishing Institute (MDPI)
Universität Potsdam
https://publishup.uni-potsdam.de/files/40007/phr333_online.pdf