38033
2014
2014
eng
21
33
13
1
33
article
Springer
New York
1
--
--
--
Auxin and its role in plant senescence
Leaf senescence represents a key developmental process through which resources trapped in the photosynthetic organ are degraded in an organized manner and transported away to sustain the growth of other organs including newly forming leaves, roots, seeds, and fruits. The optimal timing of the initiation and progression of senescence are thus prerequisites for controlled plant growth, biomass accumulation, and evolutionary success through seed dispersal. Recent research has uncovered a multitude of regulatory factors including transcription factors, micro-RNAs, protein kinases, and others that constitute the molecular networks that regulate senescence in plants. The timing of senescence is affected by environmental conditions and abiotic or biotic stresses typically trigger a faster senescence. Various phytohormones, including for example ethylene, abscisic acid, and salicylic acid, promote senescence, whereas cytokinins delay it. Recently, several reports have indicated an involvement of auxin in the control of senescence, however, its mode of action and point of interference with senescence control mechanisms remain vaguely defined at present and contrasting observations regarding the effect of auxin on senescence have so far hindered the establishment of a coherent model. Here, we summarize recent studies on auxin-related genes that affect senescence in plants and highlight how these findings might be integrated into current molecular-regulatory models of senescence.
Journal of plant growth regulation
10.1007/s00344-013-9398-5
0721-7595
1435-8107
wos:2014
WOS:000331714000003
Mueller-Roeber, B (reprint author), Univ Potsdam, Inst Biochem & Biol, Karl Liebknecht Str 24-25,Haus 20, D-14476 Potsdam, Germany., bmr@uni-potsdam.de; balazadeh@mpimp-golm.mpg.de
Deutsche Forschungsgemeinschaft (DFG) [FOR 948, MU 1199/14-1, MU
1199/14-2, BA4769/1-2]; University of Potsdam; Max-Planck Institute of
Molecular Plant Physiology, Potsdam-Golm
Bernd Müller-Röber
Salma Balazadeh
eng
uncontrolled
ARF
eng
uncontrolled
Auxin
eng
uncontrolled
Chloroplast
eng
uncontrolled
Development
eng
uncontrolled
Leaf
eng
uncontrolled
SAUR
eng
uncontrolled
Senescence
eng
uncontrolled
Signaling
eng
uncontrolled
Transcription factor
eng
uncontrolled
YUCCA
Institut für Biochemie und Biologie
Referiert
38263
2014
2014
eng
18
15
article
BioMed Central
London
1
2014-03-03
2014-03-03
--
Dynamics of chromatin accessibility and gene regulation by MADS-domain transcription factors in flower development
Background: Development of eukaryotic organisms is controlled by transcription factors that trigger specific and global changes in gene expression programs. In plants, MADS-domain transcription factors act as master regulators of developmental switches and organ specification. However, the mechanisms by which these factors dynamically regulate the expression of their target genes at different developmental stages are still poorly understood.
Results: We characterized the relationship of chromatin accessibility, gene expression, and DNA binding of two MADS-domain proteins at different stages of Arabidopsis flower development. Dynamic changes in APETALA1 and SEPALLATA3 DNA binding correlated with changes in gene expression, and many of the target genes could be associated with the developmental stage in which they are transcriptionally controlled. We also observe dynamic changes in chromatin accessibility during flower development. Remarkably, DNA binding of APETALA1 and SEPALLATA3 is largely independent of the accessibility status of their binding regions and it can precede increases in DNA accessibility. These results suggest that APETALA1 and SEPALLATA3 may modulate chromatin accessibility, thereby facilitating access of other transcriptional regulators to their target genes.
Conclusions: Our findings indicate that different homeotic factors regulate partly overlapping, yet also distinctive sets of target genes in a partly stage-specific fashion. By combining the information from DNA-binding and gene expression data, we are able to propose models of stage-specific regulatory interactions, thereby addressing dynamics of regulatory networks throughout flower development. Furthermore, MADS-domain TFs may regulate gene expression by alternative strategies, one of which is modulation of chromatin accessibility.
Genome biology : biology for the post-genomic era
10.1186/gb-2014-15-3-r41
1465-6906
1474-760X
24581456
wos:2014
R41
WOS:000338981300002
Riechmann, JL (reprint author), Ctr Res Agr Genom CSIC IRTA UAB UB, Campus UAB, Barcelona 08193, Spain., joseluis.riechmann@cragenomica.es; kerstin.kaufmann@uni-potsdam.de
NWO-VIDI grant; Marie-Curie-ITN network grant SYSFLO [237909]; Alexander-von-Humboldt foundation; Spanish Ministerio de Ciencia e Innovacion [BFU2011-22734]; EMBO
2040529-7
Riechmann, José-Luis ; Kaufmann, Kerstin
<a href="https://doi.org/10.25932/publishup-43113">Zweitveröffentlichung in der Schriftenreihe Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe ; 1327</a>
Alice Pajoro
Pedro Madrigal
Jose M. Muino
Jose Tomas Matus
Jian Jin
Martin A. Mecchia
Juan M. Debernardi
Javier F. Palatnik
Salma Balazadeh
Muhammad Arif
Frank Wellmer
Pawel Krajewski
Jose-Luis Riechmann
Gerco C. Angenent
Kerstin Kaufmann
eng
uncontrolled
Flower Development
eng
uncontrolled
Floral Organ
eng
uncontrolled
Floral Meristem
eng
uncontrolled
Chromatin Accessibility
eng
uncontrolled
Growth Regulate Factor
Biowissenschaften; Biologie
Institut für Biochemie und Biologie
Referiert
Gold Open-Access
43113
2014
2014
eng
19
15
postprint
1
2014-03-03
2014-03-03
--
Dynamics of chromatin accessibility and gene regulation by MADS-domain transcription factors in flower development
Background: Development of eukaryotic organisms is controlled by transcription factors that trigger specific and global changes in gene expression programs. In plants, MADS-domain transcription factors act as master regulators of developmental switches and organ specification. However, the mechanisms by which these factors dynamically regulate the expression of their target genes at different developmental stages are still poorly understood.
Results: We characterized the relationship of chromatin accessibility, gene expression, and DNA binding of two MADS-domain proteins at different stages of Arabidopsis flower development. Dynamic changes in APETALA1 and SEPALLATA3 DNA binding correlated with changes in gene expression, and many of the target genes could be associated with the developmental stage in which they are transcriptionally controlled. We also observe dynamic changes in chromatin accessibility during flower development. Remarkably, DNA binding of APETALA1 and SEPALLATA3 is largely independent of the accessibility status of their binding regions and it can precede increases in DNA accessibility. These results suggest that APETALA1 and SEPALLATA3 may modulate chromatin accessibility, thereby facilitating access of other transcriptional regulators to their target genes.
Conclusions: Our findings indicate that different homeotic factors regulate partly overlapping, yet also distinctive sets of target genes in a partly stage-specific fashion. By combining the information from DNA-binding and gene expression data, we are able to propose models of stage-specific regulatory interactions, thereby addressing dynamics of regulatory networks throughout flower development. Furthermore, MADS-domain TFs may regulate gene expression by alternative strategies, one of which is modulation of chromatin accessibility.
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
10.25932/publishup-43113
urn:nbn:de:kobv:517-opus4-431139
1866-8372
24581456
online registration
Version of record
Genome biology 15 (2014), Art. R41. DOI: https://doi.org/10.1186/gb-2014-15-3-r41
<a href="http://publishup.uni-potsdam.de/38263">Bibliographieeintrag der Originalveröffentlichung/Quelle</a>
false
false
Alice Pajoro
Pedro Madrigal
Jose M. Muiño
José Tomás Matus
Jian Jin
Martin A. Mecchia
Juan M. Debernardi
Javier F. Palatnik
Salma Balazadeh
Muhammad Arif
Diarmuid S. Ó’Maoiléidigh
Frank Wellmer
Pawel Krajewski
José-Luis Riechmann
Gerco C. Angenent
Kerstin Kaufmann
Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
1327
eng
uncontrolled
flower development
eng
uncontrolled
floral organ
eng
uncontrolled
floral meristem
eng
uncontrolled
chromatin accessibility
eng
uncontrolled
growth regulate factor
Biowissenschaften; Biologie
open_access
Institut für Biochemie und Biologie
Referiert
Green Open-Access
Universität Potsdam
https://publishup.uni-potsdam.de/files/43113/zmnr1327.pdf
37734
2014
2014
eng
3975
3992
18
14
65
article
Oxford Univ. Press
Oxford
1
--
--
--
Reversal of senescence by N resupply to N-starved Arabidopsis thaliana: transcriptomic and metabolomic consequences
Leaf senescence is a developmentally controlled process, which is additionally modulated by a number of adverse environmental conditions. Nitrogen shortage is a well-known trigger of precocious senescence in many plant species including crops, generally limiting biomass and seed yield. However, leaf senescence induced by nitrogen starvation may be reversed when nitrogen is resupplied at the onset of senescence. Here, the transcriptomic, hormonal, and global metabolic rearrangements occurring during nitrogen resupply-induced reversal of senescence in Arabidopsis thaliana were analysed. The changes induced by senescence were essentially in keeping with those previously described; however, these could, by and large, be reversed. The data thus indicate that plants undergoing senescence retain the capacity to sense and respond to the availability of nitrogen nutrition. The combined data are discussed in the context of the reversibility of the senescence programme and the evolutionary benefit afforded thereby. Future prospects for understanding and manipulating this process in both Arabidopsis and crop plants are postulated.
Journal of experimental botany
10.1093/jxb/eru119
24692653
0022-0957
1460-2431
wos:2014
WOS:000339954000016
Humbeck, K (reprint author), Univ Halle Wittenberg, Inst Biol, Weinbergweg 10, D-06120 Halle, Germany., klaus.humbeck@pflanzenphys.uni-halle.de; bmr@uni-potsdam.de
Deutsche Forschungsgemeinschaft (DFG) [FOR 948, MU 1199/14-2, BA4769/1-2]; DFG [HU 376/13-2]; Interdisciplinary Center for Crop Plant Research (IZN), state of Saxony-Anhalt, Germany; Spanish Government [BFU2012-32057]; Max-Planck-Society
Salma Balazadeh
Joerg Schildhauer
Wagner L. Araujo
Sergi Munne-Bosch
Alisdair R. Fernie
Sebastian Proost
Klaus Humbeck
Bernd Müller-Röber
eng
uncontrolled
Arabidopsis
eng
uncontrolled
gene expression
eng
uncontrolled
metabolomics
eng
uncontrolled
nitrogen limitation
eng
uncontrolled
senescence
eng
uncontrolled
transcriptome
Institut für Biochemie und Biologie
Referiert
37735
2014
2014
eng
3993
4008
16
14
65
article
Oxford Univ. Press
Oxford
1
--
--
--
Salt stress and senescence: identification of cross-talk regulatory components
Leaf senescence is an active process with a pivotal impact on plant productivity. It results from extensive signalling cross-talk coordinating environmental factors with intrinsic age-related mechanisms. Although many studies have shown that leaf senescence is affected by a range of external parameters, knowledge about the regulatory systems that govern the interplay between developmental programmes and environmental stress is still vague. Salinity is one of the most important environmental stresses that promote leaf senescence and thus affect crop yield. Improving salt tolerance by avoiding or delaying senescence under stress will therefore play an important role in maintaining high agricultural productivity. Experimental evidence suggests that hydrogen peroxide (H2O2) functions as a common signalling molecule in both developmental and salt-induced leaf senescence. In this study, microarray-based gene expression profiling on Arabidopsis thaliana plants subjected to long-term salinity stress to induce leaf senescence was performed, together with co-expression network analysis for H2O2-responsive genes that are mutually up-regulated by salt induced-and developmental leaf senescence. Promoter analysis of tightly co-expressed genes led to the identification of seven cis-regulatory motifs, three of which were known previously, namely CACGTGT and AAGTCAA, which are associated with reactive oxygen species (ROS)-responsive genes, and CCGCGT, described as a stress-responsive regulatory motif, while the others, namely ACGCGGT, AGCMGNC, GMCACGT, and TCSTYGACG were not characterized previously. These motifs are proposed to be novel elements involved in the H2O2-mediated control of gene expression during salinity stress-triggered and developmental senescence, acting through upstream transcription factors that bind to these sites.
Journal of experimental botany
10.1093/jxb/eru173
24803504
0022-0957
1460-2431
wos:2014
WOS:000339954000017
Balazadeh, S (reprint author), Univ Potsdam, Inst Biochem & Biol, Karl Liebknecht Str 24-25,Haus 20, D-14476 Potsdam, Germany., balazadeh@mpimp-golm.mpg.de
Deutsche Forschungsgemeinschaft [FOR 948, BA4769/1-2]; German Academic
Exchange Service (DAAD) [A/07/71707]; University of Potsdam; Max-Planck
Institute of Molecular Plant Physiology, Potsdam-Golm
Annapurna Devi Allu
Aleksandra Maria Soja
Anhui Wu
Jedrzej Szymanski
Salma Balazadeh
eng
uncontrolled
Arabidopsis
eng
uncontrolled
hydrogen peroxide
eng
uncontrolled
longevity
eng
uncontrolled
reactive oxygen species
eng
uncontrolled
salt stress
eng
uncontrolled
senescence
eng
uncontrolled
signal cross-talk
eng
uncontrolled
transcription factor
Institut für Biochemie und Biologie
Referiert
37670
2014
2014
eng
1264
1266
3
8
7
preprint
Cell Press
Cambridge
1
--
--
--
Stay-green not always stays green
Molecular plant
10.1093/mp/ssu076
24996917
1674-2052
1752-9867
wos:2014
WOS:000340438200003
Balazadeh, S (reprint author), Univ Potsdam, Inst Biochem & Biol, Karl Liebknecht Str 24-25,Haus 20, D-14476 Potsdam, Germany., balazadeh@mpimp-golm.mpg.de
Salma Balazadeh
Institut für Biochemie und Biologie
Referiert