39133
2015
2015
eng
455
463
9
3
122
article
Springer
Wien
1
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--
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Role of CNR1 polymorphisms in moderating the effects of psychosocial adversity on impulsivity in adolescents
Enhanced endocannabinoid signaling has been implicated in typically adolescent behavioral features such as increased risk-taking, impulsivity and novelty seeking. Research investigating the impact of genetic variants in the cannabinoid receptor 1 gene (CNR1) and of early rearing conditions has demonstrated that both factors contribute to the prediction of impulsivity-related phenotypes. The present study aimed to test the hypothesis of an interaction of the two most studied CNR1 polymorphisms rs806379 and rs1049353 with early psychosocial adversity in terms of affecting impulsivity in 15-year-olds from an epidemiological cohort sample followed since birth. In 323 adolescents (170 girls, 153 boys), problems of impulse control and novelty seeking were assessed using parent-report and self-report, respectively. Exposure to early psychosocial adversity was determined in a parent interview conducted at the age of 3 months. The results indicated that impulsivity increased following exposure to early psychosocial adversity, with this increase being dependent on CNR1 genotype. In contrast, while individuals exposed to early adversity scored higher on novelty seeking, no significant impact of genotype or the interaction thereof was detected. This is the first evidence to suggest that the interaction of CNR1 gene variants with the experience of early life adversity may play a role in determining adolescent impulsive behavior. However, given that the reported findings are obtained in a high-risk community sample, results are restricted in terms of interpretation and generalization. Future research is needed to replicate these findings and to identify the mediating mechanisms underlying this effect.
Journal of neural transmission
10.1007/s00702-014-1266-3
24980155
0300-9564
1435-1463
wos:2015
WOS:000350033100014
Laucht, M (reprint author), Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Child & Adolescent Psychiat & Psychotherapy, J 5, D-68159 Mannheim, Germany., manfred.laucht@zi-mannheim.de
German Research Foundation (DFG); Federal Ministry for Education and
Arlette F. Buchmann
Erika Hohm
Stephanie H. Witt
Dorothea Blomeyer
Christine Jennen-Steinmetz
Martin H. Schmidt
Günter Esser
Tobias Banaschewski
Daniel Brandeis
Manfred Laucht
eng
uncontrolled
CNR1
eng
uncontrolled
Impulsivity
eng
uncontrolled
Early psychosocial adversity
eng
uncontrolled
Adolescence
Referiert
Department Psychologie
Institut für Psychologie
34825
2013
2013
eng
902
909
8
8
23
article
Elsevier
Amsterdam
1
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BDNF Val 66 Met and 5-HTTLPR genotype moderate the impact of early psychosocial adversity on plasma brain-derived neurotrophic factor and depressive symptoms - a prospective study
Recent studies have emphasized an important role for neurotrophins, such as brain-derived neurotrophic factor (BDNF), in regulating the plasticity of neural circuits involved in the pathophysiology of stress-related diseases. The aim of the present study was to examine the interplay of the BDNF Val(66)Met and the serotonin transporter promoter (5-HTTLPR) polymorphisms in moderating the impact of early-life adversity on BDNF plasma concentration and depressive symptoms. Participants were taken from an epidemiological cohort study following the long-term outcome of early risk factors from birth into young adulthood. In 259 individuals (119 males, 140 females), genotyped for the BDNF Val(66)Met and the 5-HTTLPR polymorphisms, plasma BDNF was assessed at the age of 19 years. In addition, participants completed the Beck Depression Inventory (BDI). Early adversity was determined according to a family adversity index assessed at 3 months of age. Results indicated that individuals homozygous for both the BDNF Val and the 5-HTTLPR L allele showed significantly reduced BDNF levels following exposure to high adversity. In contrast, BDNF levels appeared to be unaffected by early psychosocial adversity in carriers of the BDNF Met or the 5-HTTLPR S allele. While the former group appeared to be most susceptible to depressive symptoms, the impact of early adversity was less pronounced in the latter group. This is the first preliminary evidence indicating that early-life adverse experiences may have lasting sequelae for plasma BDNF levels in humans, highlighting that the susceptibility to this effect is moderated by BDNF Val(66)Met and 5-HTTLPR genotype.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
10.1016/j.euroneuro.2012.09.003
0924-977X
wos:2011-2013
WOS:000324602700019
Laucht, M (reprint author), Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Child & Adolescent Psychiat & Psychotherapy, J5, D-68159 Mannheim, Germany., manfred.laucht@zi-mannheim.de
German Research Foundation (DFG); Federal Ministry for Education and
Research as part of the 'Baden-Wuerttemberg Consortium for Addiction
Research'; National Genome Research Network
Arlette F. Buchmann
Rainer Hellweg
Marcella Rietschel
Jens Treutlein
Stephanie H. Witt
Ulrich S. Zimmermann
Martin H. Schmidt
Günter Esser
Tobias Banaschewski
Manfred Laucht
Michael Deuschle
eng
uncontrolled
BDNF
eng
uncontrolled
5-HTTLPR
eng
uncontrolled
Human
eng
uncontrolled
Early psychosocial adversity
eng
uncontrolled
Longitudinal study
eng
uncontrolled
Depression
Referiert
Department Psychologie
Institut für Psychologie