37060
2011
2011
eng
139
147
9
2
52
article
Wiley-Blackwell
Malden
1
--
--
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The child behavior checklist-dysregulation profile predicts substance use, suicidality, and functional impairment a longitudinal analysis
Background:
Recent studies have identified a Child Behavior Checklist profile that characterizes children with severe affective and behavioral dysregulation (CBCL-dysregulation profile, CBCL-DP). In two recent longitudinal studies the CBCL-DP in childhood was associated with heightened rates of comorbid psychiatric disorders, among them bipolar disorder, an increased risk for suicidality, and marked psychosocial impairment at young-adult follow-up. This is the first study outside the US that examines the longitudinal course of the CBCL-DP.
Methods:
We studied the diagnostic and functional trajectories and the predictive utility of the CBCL-DP in the Mannheim Study of Children at Risk, an epidemiological cohort study on the outcome of early risk factors from birth into adulthood. A total of 325 young adults (151 males, 174 females) participated in the 19-year assessment.
Results:
Young adults with a higher CBCL-DP score in childhood were at increased risk for substance use disorders, suicidality and poorer overall functioning at age 19, even after adjustment for parental education, family income, impairment and psychiatric disorders at baseline. Childhood dysregulation was not related to bipolar disorder in young adulthood. The CBCL-DP was neither a precursor of a specific pattern of comorbidity nor of comorbidity in general.
Conclusions:
Children with high CBCL-DP values are at risk for later severe, psychiatric symptomatology. The different developmental trajectories suggest that the CBCL-DP is not simply an early manifestation of a single disease process but might rather be an early developmental risk marker of a persisting deficit of self-regulation of affect and behavior.
The journal of child psychology and psychiatry
10.1111/j.1469-7610.2010.02309.x
0021-9630
wos:2011-2013
WOS:000286207700005
Holtmann, M (reprint author), Ruhr Univ Bochum, LWL Univ Hosp Child & Adolescent Psychiat, Heithofer Allee 64, D-59071 Hamm, Germany., martin.holtmann@wkp-lwl.org
Lilly; Janssen McNeil; Medice; Novartis; UCB; Shire
Martin Holtmann
Arlette F. Buchmann
Günter Esser
Martin H. Schmidt
Tobias Banaschewski
Manfred Laucht
eng
uncontrolled
Dysregulation
eng
uncontrolled
childhood
eng
uncontrolled
comorbidity
eng
uncontrolled
longitudinal
eng
uncontrolled
irritability
eng
uncontrolled
depression
eng
uncontrolled
ADHD
eng
uncontrolled
substance use
eng
uncontrolled
suicidality
eng
uncontrolled
CBCL
eng
uncontrolled
bipolar
Referiert
Department Psychologie
Institut für Psychologie
38481
2015
2015
eng
83
90
8
70
article
Elsevier
Oxford
1
--
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Interacting effects of maternal responsiveness, infant regulatory problems and dopamine D4 receptor gene in the development of dysregulation during childhood: A longitudinal analysis
Recent longitudinal studies have indicated that affective and behavioral dysregulation in childhood is associated with an increased risk for various negative outcomes in later life. However, few studies to date have examined early mechanisms preceding dysregulation during early childhood. Aim of this study was to elucidate early mechanisms relating to dysregulation in later life using data from an epidemiological cohort study on the long-term outcome of early risk factors from birth to adulthood. At age 3 months, mothers and infants were videotaped during a nursing and playing situation. Maternal responsiveness was evaluated by trained raters. Infant regulatory problems were assessed on the basis of a parent interview and direct observation by trained raters. At age 8 and 11 years, 290 children (139 males) were rated on the Child Behavior Checklist (CBCL). Additionally, participants were genotyped for the dopamine D4 receptor (DRD4) exon 3 VNTR polymorphism. A significant three-way interaction between maternal responsiveness, DRD4 genotype and infant regulatory problems was detected predicting the CBCL-dysregulation profile (CBCL-DP). Carriers of the DRD4 7r allele with regulatory problems at age 3 months showed significantly more behavior problems associated with the CBCL-DP during childhood when exposed to less maternal responsiveness. In contrast, no effect of maternal responsiveness was observed in DRD4 7r carriers without infant regulatory problems and in non-carriers of the DRD4 7r allele. This prospective longitudinal study extends earlier findings regarding the association of the CBCL-DP with early parenting and later psychopathology, introducing both DRD4 genotype and infant regulatory problems as important moderators. (C) 2015 Elsevier Ltd. All rights reserved.
Journal of psychiatric research
10.1016/j.psychires.2015.08.018
26424426
0022-3956
1879-1379
wos:2015
WOS:000363826800010
Poustka, L (reprint author), Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Child & Adolescent Psychiat & Psychotherapy, POB 122120, D-68072 Mannheim, Germany., luise.poustka@zi-mannheim.de
German Research Foundation (DFG)
Luise Poustka
Katrin Zohsel
Dorothea Blomeyer
Christine Jennen-Steinmetz
Brigitte Schmid
Patricia Trautmann-Villalba
Sarah Hohmann
Katja Becker
Günter Esser
Martin H. Schmidt
Daniel Brandeis
Tobias Banaschewski
Manfred Laucht
eng
uncontrolled
Dysregulation
eng
uncontrolled
Childhood
eng
uncontrolled
Infant regulatory problems
eng
uncontrolled
Parenting quality
eng
uncontrolled
DRD4
eng
uncontrolled
Gene-environment interaction
Referiert
Department Psychologie
Institut für Psychologie