Dokument-ID Dokumenttyp Verfasser/Autoren Herausgeber Haupttitel Abstract Auflage Verlagsort Verlag Erscheinungsjahr Seitenzahl Schriftenreihe Titel Schriftenreihe Bandzahl ISBN Quelle der Hochschulschrift Konferenzname Quelle:Titel Quelle:Jahrgang Quelle:Heftnummer Quelle:Erste Seite Quelle:Letzte Seite URN DOI Abteilungen OPUS4-43106 misc Hägele, Claudia; Schlagenhauf, Florian; Rapp, Michael Armin; Sterzer, Philipp; Beck, Anne; Bermpohl, Felix; Stoy, Meline; Ströhle, Andreas; Wittchen, Hans-Ulrich; Dolan, Raymond J.; Heinz, Andreas Dimensional psychiatry A dimensional approach in psychiatry aims to identify core mechanisms of mental disorders across nosological boundaries. We compared anticipation of reward between major psychiatric disorders, and investigated whether reward anticipation is impaired in several mental disorders and whether there is a common psychopathological correlate (negative mood) of such an impairment. We used functional magnetic resonance imaging (fMRI) and a monetary incentive delay (MID) task to study the functional correlates of reward anticipation across major psychiatric disorders in 184 subjects, with the diagnoses of alcohol dependence (n = 26), schizophrenia (n = 44), major depressive disorder (MDD, n = 24), bipolar disorder (acute manic episode, n = 13), attention deficit/hyperactivity disorder (ADHD, n = 23), and healthy controls (n = 54). Subjects' individual Beck Depression Inventory-and State-Trait Anxiety Inventory-scores were correlated with clusters showing significant activation during reward anticipation. During reward anticipation, we observed significant group differences in ventral striatal (VS) activation: patients with schizophrenia, alcohol dependence, and major depression showed significantly less ventral striatal activation compared to healthy controls. Depressive symptoms correlated with dysfunction in reward anticipation regardless of diagnostic entity. There was no significant correlation between anxiety symptoms and VS functional activation. Our findings demonstrate a neurobiological dysfunction related to reward prediction that transcended disorder categories and was related to measures of depressed mood. The findings underline the potential of a dimensional approach in psychiatry and strengthen the hypothesis that neurobiological research in psychiatric disorders can be targeted at core mechanisms that are likely to be implicated in a range of clinical entities. 2014 13 Postprints der Universität Potsdam : Humanwissenschaftliche Reihe 653 331 341 urn:nbn:de:kobv:517-opus4-431064 10.25932/publishup-43106 Department Sport- und Gesundheitswissenschaften OPUS4-39404 Wissenschaftlicher Artikel Haegele, Claudia; Schlagenhauf, Florian; Rapp, Michael Armin; Sterzer, Philipp; Beck, Anne; Bermpohl, Felix; Stoy, Meline; Stroehle, Andreas; Wittchen, Hans-Ulrich; Dolan, Raymond J.; Heinz, Andreas Dimensional psychiatry: reward dysfunction and depressive mood across psychiatric disorders A dimensional approach in psychiatry aims to identify core mechanisms of mental disorders across nosological boundaries. We compared anticipation of reward between major psychiatric disorders, and investigated whether reward anticipation is impaired in several mental disorders and whether there is a common psychopathological correlate (negative mood) of such an impairment. During reward anticipation, we observed significant group differences in ventral striatal (VS) activation: patients with schizophrenia, alcohol dependence, and major depression showed significantly less ventral striatal activation compared to healthy controls. Depressive symptoms correlated with dysfunction in reward anticipation regardless of diagnostic entity. There was no significant correlation between anxiety symptoms and VS functional activation. Our findings demonstrate a neurobiological dysfunction related to reward prediction that transcended disorder categories and was related to measures of depressed mood. The findings underline the potential of a dimensional approach in psychiatry and strengthen the hypothesis that neurobiological research in psychiatric disorders can be targeted at core mechanisms that are likely to be implicated in a range of clinical entities. New York Springer 2015 11 Psychopharmacology 232 2 331 341 10.1007/s00213-014-3662-7 Department Sport- und Gesundheitswissenschaften OPUS4-37913 Konferenzveröffentlichung Haegele, Claudia; Friedel, Eva; Schlagenhauf, Florian; Sterzer, Philipp; Beck, Anne; Bermpohl, Felix; Rapp, Michael Armin; Stoy, Meline; Stroehle, Andreas; Dolan, Raymond J.; Heinz, Andreas Reward expectation and affective responses across psychiatric disorders - A dimensional approach New York Elsevier 2014 2 Biological psychiatry : a journal of psychiatric neuroscience and therapeutics ; a publication of the Society of Biological Psychiatry 75 9 91S 92S Strukturbereich Kognitionswissenschaften OPUS4-43514 misc Friedel, Eva; Schlagenhauf, Florian; Beck, Anne; Dolan, Raymond J.; Huys, Quentin J. M.; Rapp, Michael Armin; Heinz, Andreas The effects of life stress and neural learning signals on fluid intelligence Fluid intelligence (fluid IQ), defined as the capacity for rapid problem solving and behavioral adaptation, is known to be modulated by learning and experience. Both stressful life events (SLES) and neural correlates of learning [specifically, a key mediator of adaptive learning in the brain, namely the ventral striatal representation of prediction errors (PE)] have been shown to be associated with individual differences in fluid IQ. Here, we examine the interaction between adaptive learning signals (using a well-characterized probabilistic reversal learning task in combination with fMRI) and SLES on fluid IQ measures. We find that the correlation between ventral striatal BOLD PE and fluid IQ, which we have previously reported, is quantitatively modulated by the amount of reported SLES. Thus, after experiencing adversity, basic neuronal learning signatures appear to align more closely with a general measure of flexible learning (fluid IQ), a finding complementing studies on the effects of acute stress on learning. The results suggest that an understanding of the neurobiological correlates of trait variables like fluid IQ needs to take socioemotional influences such as chronic stress into account. 2014 11 Postprints der Universität Potsdam : Humanwissenschaftliche Reihe 621 35 43 urn:nbn:de:kobv:517-opus4-435140 10.25932/publishup-43514 Humanwissenschaftliche Fakultät OPUS4-39219 Wissenschaftlicher Artikel Friedel, Eva; Schlagenhauf, Florian; Beck, Anne; Dolan, Raymond J.; Huys, Quentin J. M.; Rapp, Michael Armin; Heinz, Andreas The effects of life stress and neural learning signals on fluid intelligence Fluid intelligence (fluid IQ), defined as the capacity for rapid problem solving and behavioral adaptation, is known to be modulated by learning and experience. Both stressful life events (SLES) and neural correlates of learning [specifically, a key mediator of adaptive learning in the brain, namely the ventral striatal representation of prediction errors (PE)] have been shown to be associated with individual differences in fluid IQ. Here, we examine the interaction between adaptive learning signals (using a well-characterized probabilistic reversal learning task in combination with fMRI) and SLES on fluid IQ measures. We find that the correlation between ventral striatal BOLD PE and fluid IQ, which we have previously reported, is quantitatively modulated by the amount of reported SLES. Thus, after experiencing adversity, basic neuronal learning signatures appear to align more closely with a general measure of flexible learning (fluid IQ), a finding complementing studies on the effects of acute stress on learning. The results suggest that an understanding of the neurobiological correlates of trait variables like fluid IQ needs to take socioemotional influences such as chronic stress into account. Heidelberg Springer 2015 9 European archives of psychiatry and clinical neuroscience : official organ of the German Society for Biological Psychiatry 265 1 35 43 10.1007/s00406-014-0519-3 Department Sport- und Gesundheitswissenschaften