Dokument-ID Dokumenttyp Verfasser/Autoren Herausgeber Haupttitel Abstract Auflage Verlagsort Verlag Erscheinungsjahr Seitenzahl Schriftenreihe Titel Schriftenreihe Bandzahl ISBN Quelle der Hochschulschrift Konferenzname Quelle:Titel Quelle:Jahrgang Quelle:Heftnummer Quelle:Erste Seite Quelle:Letzte Seite URN DOI Abteilungen OPUS4-38277 Wissenschaftlicher Artikel Neffe, Axel T.; von Rüsten-Lange, Maik; Braune, Steffen; Lützow, Karola; Roch, Toralf; Richau, Klaus; Krüger, Anne; Becherer, Tobias; Thünemann, Andreas F.; Jung, Friedrich; Haag, Rainer; Lendlein, Andreas Multivalent grafting of hyperbranched oligo- and polyglycerols shielding rough membranes to mediate hemocompatibility Hemocompatible materials are needed for internal and extracorporeal biomedical applications, which should be realizable by reducing protein and thrombocyte adhesion to such materials. Polyethers have been demonstrated to be highly efficient in this respect on smooth surfaces. Here, we investigate the grafting of oligo- and polyglycerols to rough poly(ether imide) membranes as a polymer relevant to biomedical applications and show the reduction of protein and thrombocyte adhesion as well as thrombocyte activation. It could be demonstrated that, by performing surface grafting with oligo-and polyglycerols of relatively high polydispersity (>1.5) and several reactive groups for surface anchoring, full surface shielding can be reached, which leads to reduced protein adsorption of albumin and fibrinogen. In addition, adherent thrombocytes were not activated. This could be clearly shown by immunostaining adherent proteins and analyzing the thrombocyte covered area. The presented work provides an important strategy for the development of application relevant hemocompatible 3D structured materials. Cambridge Royal Society of Chemistry 2014 10 Journal of materials chemistry : B, Materials for biology and medicine 2 23 3626 3635 10.1039/c4tb00184b Institut für Chemie OPUS4-9944 misc Neffe, Axel T.; von Rüsten-Lange, Maik; Braune, Steffen; Lützow, Karola; Roch, Toralf; Richau, Klaus; Krüger, Anne; Becherer, Tobias; Thünemann, Andreas F.; Jung, Friedrich; Haag, Rainer; Lendlein, Andreas Multivalent grafting of hyperbranched oligo- and polyglycerols shielding rough membranes to mediate hemocompatibility Hemocompatible materials are needed for internal and extracorporeal biomedical applications, which should be realizable by reducing protein and thrombocyte adhesion to such materials. Polyethers have been demonstrated to be highly efficient in this respect on smooth surfaces. Here, we investigate the grafting of oligo- and polyglycerols to rough poly(ether imide) membranes as a polymer relevant to biomedical applications and show the reduction of protein and thrombocyte adhesion as well as thrombocyte activation. It could be demonstrated that, by performing surface grafting with oligo- and polyglycerols of relatively high polydispersity (>1.5) and several reactive groups for surface anchoring, full surface shielding can be reached, which leads to reduced protein adsorption of albumin and fibrinogen. In addition, adherent thrombocytes were not activated. This could be clearly shown by immunostaining adherent proteins and analyzing the thrombocyte covered area. The presented work provides an important strategy for the development of application relevant hemocompatible 3D structured materials. 2014 urn:nbn:de:kobv:517-opus4-99444 Institut für Chemie OPUS4-37765 Wissenschaftlicher Artikel Dey, Pradip; Adamovski, Miriam; Friebe, Simon; Badalyan, Artavazd; Mutihac, Radu-Cristian; Paulus, Florian; Leimkühler, Silke; Wollenberger, Ursula; Haag, Rainer Dendritic polyglycerol-poly(ethylene glycol)-based polymer networks for biosensing application This work describes the formation of a new dendritic polyglycerol-poly(ethylene glycol)-based 3D polymer network as a matrix for immobilization of the redox enzyme periplasmatic aldehyde oxidoreductase to create an electrochemical biosensor. The novel network is built directly on the gold surface, where it simultaneously stabilizes the enzyme for up to 4 days. The prepared biosensors can be used for amperometric detection of benzaldehyde in the range of 0.8-400 mu M. Washington American Chemical Society 2014 5 ACS applied materials & interfaces 6 12 8937 8941 10.1021/am502018x Institut für Biochemie und Biologie