Dokument-ID Dokumenttyp Verfasser/Autoren Herausgeber Haupttitel Abstract Auflage Verlagsort Verlag Erscheinungsjahr Seitenzahl Schriftenreihe Titel Schriftenreihe Bandzahl ISBN Quelle der Hochschulschrift Konferenzname Quelle:Titel Quelle:Jahrgang Quelle:Heftnummer Quelle:Erste Seite Quelle:Letzte Seite URN DOI Abteilungen OPUS4-49661 Wissenschaftlicher Artikel Warrington, Nicole; Beaumont, Robin; Horikoshi, Momoko; Day, Felix R.; Helgeland, Øyvind; Laurin, Charles; Bacelis, Jonas; Peng, Shouneng; Hao, Ke; Feenstra, Bjarke; Wood, Andrew R.; Mahajan, Anubha; Tyrrell, Jessica; Robertson, Neil R.; Rayner, N. William; Qiao, Zhen; Moen, Gunn-Helen; Vaudel, Marc; Marsit, Carmen; Chen, Jia; Nodzenski, Michael; Schnurr, Theresia M.; Zafarmand, Mohammad Hadi; Bradfield, Jonathan P.; Grarup, Niels; Kooijman, Marjolein N.; Li-Gao, Ruifang; Geller, Frank; Ahluwalia, Tarunveer Singh; Paternoster, Lavinia; Rueedi, Rico; Huikari, Ville; Hottenga, Jouke-Jan; Lyytikäinen, Leo-Pekka; Cavadino, Alana; Metrustry, Sarah; Cousminer, Diana L.; Wu, Ying; Thiering, Elisabeth Paula; Wang, Carol A.; Have, Christian Theil; Vilor-Tejedor, Natalia; Joshi, Peter K.; Painter, Jodie N.; Ntalla, Ioanna; Myhre, Ronny; Pitkänen, Niina; van Leeuwen, Elisabeth M.; Joro, Raimo; Lagou, Vasiliki; Richmond, Rebecca C.; Espinosa, Ana; Barton, Sheila J.; Inskip, Hazel M.; Holloway, John W.; Santa-Marina, Loreto; Estivill, Xavier; Ang, Wei; Marsh, Julie A.; Reichetzeder, Christoph; Marullo, Letizia; Hocher, Berthold; Lunetta, Kathryn L.; Murabito, Joanne M.; Relton, Caroline L.; Kogevinas, Manolis; Chatzi, Leda; Allard, Catherine; Bouchard, Luigi; Hivert, Marie-France; Zhang, Ge; Muglia, Louis J.; Heikkinen, Jani; Morgen, Camilla S.; van Kampen, Antoine H. C.; van Schaik, Barbera D. C.; Mentch, Frank D.; Langenberg, Claudia; Scott, Robert A.; Zhao, Jing Hua; Hemani, Gibran; Ring, Susan M.; Bennett, Amanda J.; Gaulton, Kyle J.; Fernandez-Tajes, Juan; van Zuydam, Natalie R.; Medina-Gomez, Carolina; de Haan, Hugoline G.; Rosendaal, Frits R.; Kutalik, Zoltán; Marques-Vidal, Pedro; Das, Shikta; Willemsen, Gonneke; Mbarek, Hamdi; Müller-Nurasyid, Martina; Standl, Marie; Appel, Emil V. R.; Fonvig, Cilius Esmann; Trier, Caecilie; van Beijsterveldt, Catharina E. M.; Murcia, Mario; Bustamante, Mariona; Bonàs-Guarch, Sílvia; Hougaard, David M.; Mercader, Josep M.; Linneberg, Allan; Schraut, Katharina E.; Lind, Penelope A.; Medland, Sarah Elizabeth; Shields, Beverley M.; Knight, Bridget A.; Chai, Jin-Fang; Panoutsopoulou, Kalliope; Bartels, Meike; Sánchez, Friman; Stokholm, Jakob; Torrents, David; Vinding, Rebecca K.; Willems, Sara M.; Atalay, Mustafa; Chawes, Bo L.; Kovacs, Peter; Prokopenko, Inga; Tuke, Marcus A.; Yaghootkar, Hanieh; Ruth, Katherine S.; Jones, Samuel E.; Loh, Po-Ru; Murray, Anna; Weedon, Michael N.; Tönjes, Anke; Stumvoll, Michael; Michaelsen, Kim Fleischer; Eloranta, Aino-Maija; Lakka, Timo A.; van Duijn, Cornelia M.; Kiess, Wieland; Koerner, Antje; Niinikoski, Harri; Pahkala, Katja; Raitakari, Olli T.; Jacobsson, Bo; Zeggini, Eleftheria; Dedoussis, George V.; Teo, Yik-Ying; Saw, Seang-Mei; Montgomery, Grant W.; Campbell, Harry; Wilson, James F.; Vrijkotte, Tanja G. M.; Vrijheid, Martine; de Geus, Eco J. C. N.; Hayes, M. Geoffrey; Kadarmideen, Haja N.; Holm, Jens-Christian; Beilin, Lawrence J.; Pennell, Craig E.; Heinrich, Joachim; Adair, Linda S.; Borja, Judith B.; Mohlke, Karen L.; Eriksson, Johan G.; Widen, Elisabeth E.; Hattersley, Andrew T.; Spector, Tim D.; Kaehoenen, Mika; Viikari, Jorma S.; Lehtimaeki, Terho; Boomsma, Dorret I.; Sebert, Sylvain; Vollenweider, Peter; Sorensen, Thorkild I. A.; Bisgaard, Hans; Bonnelykke, Klaus; Murray, Jeffrey C.; Melbye, Mads; Nohr, Ellen A.; Mook-Kanamori, Dennis O.; Rivadeneira, Fernando; Hofman, Albert; Felix, Janine F.; Jaddoe, Vincent W. V.; Hansen, Torben; Pisinger, Charlotta; Vaag, Allan A.; Pedersen, Oluf; Uitterlinden, Andre G.; Jarvelin, Marjo-Riitta; Power, Christine; Hypponen, Elina; Scholtens, Denise M.; Lowe, William L.; Smith, George Davey; Timpson, Nicholas J.; Morris, Andrew P.; Wareham, Nicholas J.; Hakonarson, Hakon; Grant, Struan F. A.; Frayling, Timothy M.; Lawlor, Debbie A.; Njolstad, Pal R.; Johansson, Stefan; Ong, Ken K.; McCarthy, Mark I.; Perry, John R. B.; Evans, David M.; Freathy, Rachel M. Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors, and has been reproducibly associated with future cardio-metabolic health outcomes. In expanded genome-wide association analyses of own birth weight (n = 321,223) and offspring birth weight (n = 230,069 mothers), we identified 190 independent association signals (129 of which are novel). We used structural equation modeling to decompose the contributions of direct fetal and indirect maternal genetic effects, then applied Mendelian randomization to illuminate causal pathways. For example, both indirect maternal and direct fetal genetic effects drive the observational relationship between lower birth weight and higher later blood pressure: maternal blood pressure-raising alleles reduce offspring birth weight, but only direct fetal effects of these alleles, once inherited, increase later offspring blood pressure. Using maternal birth weight-lowering genotypes to proxy for an adverse intrauterine environment provided no evidence that it causally raises offspring blood pressure, indicating that the inverse birth weight-blood pressure association is attributable to genetic effects, and not to intrauterine programming. New York Nature Publ. Group 2019 17 Nature genetics 51 5 804 + Institut für Ernährungswissenschaft OPUS4-50042 Wissenschaftlicher Artikel Middeldorp, Christel M.; Mahajan, Anubha; Horikoshi, Momoko; Robertson, Neil R.; Beaumont, Robin N.; Bradfield, Jonathan P.; Bustamante, Mariona; Cousminer, Diana L.; Day, Felix R.; De Silva, N. Maneka; Guxens, Monica; Mook-Kanamori, Dennis O.; St Pourcain, Beate; Warrington, Nicole M.; Adair, Linda S.; Ahlqvist, Emma; Ahluwalia, Tarunveer Singh; Almgren, Peter; Ang, Wei; Atalay, Mustafa; Auvinen, Juha; Bartels, Meike; Beckmann, Jacques S.; Bilbao, Jose Ramon; Bond, Tom; Borja, Judith B.; Cavadino, Alana; Charoen, Pimphen; Chen, Zhanghua; Coin, Lachlan; Cooper, Cyrus; Curtin, John A.; Custovic, Adnan; Das, Shikta; Davies, Gareth E.; Dedoussis, George V.; Duijts, Liesbeth; Eastwood, Peter R.; Eliasen, Anders U.; Elliott, Paul; Eriksson, Johan G.; Estivill, Xavier; Fadista, Joao; Fedko, Iryna O.; Frayling, Timothy M.; Gaillard, Romy; Gauderman, W. James; Geller, Frank; Gilliland, Frank; Gilsanz, Vincente; Granell, Raquel; Grarup, Niels; Groop, Leif; Hadley, Dexter; Hakonarson, Hakon; Hansen, Torben; Hartman, Catharina A.; Hattersley, Andrew T.; Hayes, M. Geoffrey; Hebebrand, Johannes; Heinrich, Joachim; Helgeland, Oyvind; Henders, Anjali K.; Henderson, John; Henriksen, Tine B.; Hirschhorn, Joel N.; Hivert, Marie-France; Hocher, Berthold; Holloway, John W.; Holt, Patrick; Hottenga, Jouke-Jan; Hypponen, Elina; Iniguez, Carmen; Johansson, Stefan; Jugessur, Astanand; Kahonen, Mika; Kalkwarf, Heidi J.; Kaprio, Jaakko; Karhunen, Ville; Kemp, John P.; Kerkhof, Marjan; Koppelman, Gerard H.; Korner, Antje; Kotecha, Sailesh; Kreiner-Moller, Eskil; Kulohoma, Benard; Kumar, Ashish; Kutalik, Zoltan; Lahti, Jari; Lappe, Joan M.; Larsson, Henrik; Lehtimaki, Terho; Lewin, Alexandra M.; Li, Jin; Lichtenstein, Paul; Lindgren, Cecilia M.; Lindi, Virpi; Linneberg, Allan; Liu, Xueping; Liu, Jun; Lowe, William L.; Lundstrom, Sebastian; Lyytikainen, Leo-Pekka; Ma, Ronald C. W.; Mace, Aurelien; Magi, Reedik; Magnus, Per; Mamun, Abdullah A.; Mannikko, Minna; Martin, Nicholas G.; Mbarek, Hamdi; McCarthy, Nina S.; Medland, Sarah E.; Melbye, Mads; Melen, Erik; Mohlke, Karen L.; Monnereau, Claire; Morgen, Camilla S.; Morris, Andrew P.; Murray, Jeffrey C.; Myhre, Ronny; Najman, Jackob M.; Nivard, Michel G.; Nohr, Ellen A.; Nolte, Ilja M.; Ntalla, Ioanna; Oberfield, Sharon E.; Oken, Emily; Oldehinkel, Albertine J.; Pahkala, Katja; Palviainen, Teemu; Panoutsopoulou, Kalliope; Pedersen, Oluf; Pennell, Craig E.; Pershagen, Goran; Pitkanen, Niina; Plomin, Robert; Power, Christine; Prasad, Rashmi B.; Prokopenko, Inga; Pulkkinen, Lea; Raikkonen, Katri; Raitakari, Olli T.; Reynolds, Rebecca M.; Richmond, Rebecca C.; Rivadeneira, Fernando; Rodriguez, Alina; Rose, Richard J.; Salem, Rany; Santa-Marina, Loreto; Saw, Seang-Mei; Schnurr, Theresia M.; Scott, James G.; Selzam, Saskia; Shepherd, John A.; Simpson, Angela; Skotte, Line; Sleiman, Patrick M. A.; Snieder, Harold; Sorensen, Thorkild I. A.; Standl, Marie; Steegers, Eric A. P.; Strachan, David P.; Straker, Leon; Strandberg, Timo; Taylor, Michelle; Teo, Yik-Ying; Thiering, Elisabeth; Torrent, Maties; Tyrrell, Jessica; Uitterlinden, Andre G.; van Beijsterveldt, Toos; van der Most, Peter J.; van Duijn, Cornelia M.; Viikari, Jorma; Vilor-Tejedor, Natalia; Vogelezang, Suzanne; Vonk, Judith M.; Vrijkotte, Tanja G. M.; Vuoksimaa, Eero; Wang, Carol A.; Watkins, William J.; Wichmann, H-Erich; Willemsen, Gonneke; Williams, Gail M.; Wilson, James F.; Wray, Naomi R.; Xu, Shujing; Xu, Cheng-Jian; Yaghootkar, Hanieh; Yi, Lu; Zafarmand, Mohammad Hadi; Zeggini, Eleftheria; Zemel, Babette S.; Hinney, Anke; Lakka, Timo A.; Whitehouse, Andrew J. O.; Sunyer, Jordi; Widen, Elisabeth E.; Feenstra, Bjarke; Sebert, Sylvain; Jacobsson, Bo; Njolstad, Pal R.; Stoltenberg, Camilla; Smith, George Davey; Lawlor, Debbie A.; Paternoster, Lavinia; Timpson, Nicholas J.; Ong, Ken K.; Bisgaard, Hans; Bonnelykke, Klaus; Jaddoe, Vincent W. V.; Tiemeier, Henning; Jarvelin, Marjo-Riitta; Evans, David M.; Perry, John R. B.; Grant, Struan F. A.; Boomsma, Dorret I.; Freathy, Rachel M.; McCarthy, Mark I.; Felix, Janine F. The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia The impact of many unfavorable childhood traits or diseases, such as low birth weight and mental disorders, is not limited to childhood and adolescence, as they are also associated with poor outcomes in adulthood, such as cardiovascular disease. Insight into the genetic etiology of childhood and adolescent traits and disorders may therefore provide new perspectives, not only on how to improve wellbeing during childhood, but also how to prevent later adverse outcomes. To achieve the sample sizes required for genetic research, the Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia were established. The majority of the participating cohorts are longitudinal population-based samples, but other cohorts with data on early childhood phenotypes are also involved. Cohorts often have a broad focus and collect(ed) data on various somatic and psychiatric traits as well as environmental factors. Genetic variants have been successfully identified for multiple traits, for example, birth weight, atopic dermatitis, childhood BMI, allergic sensitization, and pubertal growth. Furthermore, the results have shown that genetic factors also partly underlie the association with adult traits. As sample sizes are still increasing, it is expected that future analyses will identify additional variants. This, in combination with the development of innovative statistical methods, will provide detailed insight on the mechanisms underlying the transition from childhood to adult disorders. Both consortia welcome new collaborations. Policies and contact details are available from the corresponding authors of this manuscript and/or the consortium websites. Dordrecht Springer 2019 22 European journal of epidemiology 34 3 279 300 10.1007/s10654-019-00502-9 Institut für Biochemie und Biologie OPUS4-35420 Wissenschaftlicher Artikel Horikoshi, Momoko; Yaghootkar, Hanieh; Mook-Kanamori, Dennis O.; Sovio, Ulla; Taal, H. Rob; Hennig, Branwen J.; Bradfield, Jonathan P.; St Pourcain, Beate; Evans, David M.; Charoen, Pimphen; Kaakinen, Marika; Cousminer, Diana L.; Lehtimaki, Terho; Kreiner-Moller, Eskil; Warrington, Nicole M.; Bustamante, Mariona; Feenstra, Bjarke; Berry, Diane J.; Thiering, Elisabeth; Pfab, Thiemo; Barton, Sheila J.; Shields, Beverley M.; Kerkhof, Marjan; van Leeuwen, Elisabeth M.; Fulford, Anthony J.; Kutalik, Zoltan; Zhao, Jing Hua; den Hoed, Marcel; Mahajan, Anubha; Lindi, Virpi; Goh, Liang-Kee; Hottenga, Jouke-Jan; Wu, Ying; Raitakari, Olli T.; Harder, Marie N.; Meirhaeghe, Aline; Ntalla, Ioanna; Salem, Rany M.; Jameson, Karen A.; Zhou, Kaixin; Monies, Dorota M.; Lagou, Vasiliki; Kirin, Mirna; Heikkinen, Jani; Adair, Linda S.; Alkuraya, Fowzan S.; Al-Odaib, Ali; Amouyel, Philippe; Andersson, Ehm Astrid; Bennett, Amanda J.; Blakemore, Alexandra I. F.; Buxton, Jessica L.; Dallongeville, Jean; Das, Shikta; de Geus, Eco J. C.; Estivill, Xavier; Flexeder, Claudia; Froguel, Philippe; Geller, Frank; Godfrey, Keith M.; Gottrand, Frederic; Groves, Christopher J.; Hansen, Torben; Hirschhorn, Joel N.; Hofman, Albert; Hollegaard, Mads V.; Hougaard, David M.; Hyppoenen, Elina; Inskip, Hazel M.; Isaacs, Aaron; Jorgensen, Torben; Kanaka-Gantenbein, Christina; Kemp, John P.; Kiess, Wieland; Kilpelainen, Tuomas O.; Klopp, Norman; Knight, Bridget A.; Kuzawa, Christopher W.; McMahon, George; Newnham, John P.; Niinikoski, Harri; Oostra, Ben A.; Pedersen, Louise; Postma, Dirkje S.; Ring, Susan M.; Rivadeneira, Fernando; Robertson, Neil R.; Sebert, Sylvain; Simell, Olli; Slowinski, Torsten; Tiesler, Carla M. T.; Toenjes, Anke; Vaag, Allan; Viikari, Jorma S.; Vink, Jacqueline M.; Vissing, Nadja Hawwa; Wareham, Nicholas J.; Willemsen, Gonneke; Witte, Daniel R.; Zhang, Haitao; Zhao, Jianhua; Wilson, James F.; Stumvoll, Michael; Prentice, Andrew M.; Meyer, Brian F.; Pearson, Ewan R.; Boreham, Colin A. G.; Cooper, Cyrus; Gillman, Matthew W.; Dedoussis, George V.; Moreno, Luis A.; Pedersen, Oluf; Saarinen, Maiju; Mohlke, Karen L.; Boomsma, Dorret I.; Saw, Seang-Mei; Lakka, Timo A.; Koerner, Antje; Loos, Ruth J. F.; Ong, Ken K.; Vollenweider, Peter; van Duijn, Cornelia M.; Koppelman, Gerard H.; Hattersley, Andrew T.; Holloway, John W.; Hocher, Berthold; Heinrich, Joachim; Power, Chris; Melbye, Mads; Guxens, Monica; Pennell, Craig E.; Bonnelykke, Klaus; Bisgaard, Hans; Eriksson, Johan G.; Widen, Elisabeth; Hakonarson, Hakon; Uitterlinden, Andre G.; Pouta, Anneli; Lawlor, Debbie A.; Smith, George Davey; Frayling, Timothy M.; McCarthy, Mark I.; Grant, Struan F. A.; Jaddoe, Vincent W. V.; Jarvelin, Marjo-Riitta; Timpson, Nicholas J.; Prokopenko, Inga; Freathy, Rachel M. New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood(1). Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits(2). In an expanded genome-wide association metaanalysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism. New York Nature Publ. Group 2013 10 Nature genetics 45 1 76 U115 10.1038/ng.2477 Institut für Ernährungswissenschaft OPUS4-39159 Wissenschaftlicher Artikel van der Valk, Ralf J. P.; Kreiner-Moller, Eskil; Kooijman, Marjolein N.; Guxens, Monica; Stergiakouli, Evangelia; Saaf, Annika; Bradfield, Jonathan P.; Geller, Frank; Hayes, M. Geoffrey; Cousminer, Diana L.; Koerner, Antje; Thiering, Elisabeth; Curtin, John A.; Myhre, Ronny; Huikari, Ville; Joro, Raimo; Kerkhof, Marjan; Warrington, Nicole M.; Pitkanen, Niina; Ntalla, Ioanna; Horikoshi, Momoko; Veijola, Riitta; Freathy, Rachel M.; Teo, Yik-Ying; Barton, Sheila J.; Evans, David M.; Kemp, John P.; St Pourcain, Beate; Ring, Susan M.; Smith, George Davey; Bergstrom, Anna; Kull, Inger; Hakonarson, Hakon; Mentch, Frank D.; Bisgaard, Hans; Chawes, Bo Lund Krogsgaard; Stokholm, Jakob; Waage, Johannes; Eriksen, Patrick; Sevelsted, Astrid; Melbye, Mads; van Duijn, Cornelia M.; Medina-Gomez, Carolina; Hofman, Albert; de Jongste, Johan C.; Taal, H. Rob; Uitterlinden, Andre G.; Armstrong, Loren L.; Eriksson, Johan; Palotie, Aarno; Bustamante, Mariona; Estivill, Xavier; Gonzalez, Juan R.; Llop, Sabrina; Kiess, Wieland; Mahajan, Anubha; Flexeder, Claudia; Tiesler, Carla M. T.; Murray, Clare S.; Simpson, Angela; Magnus, Per; Sengpiel, Verena; Hartikainen, Anna-Liisa; Keinanen-Kiukaanniemi, Sirkka; Lewin, Alexandra; Alves, Alexessander Da Silva Couto; Blakemore, Alexandra I. F.; Buxton, Jessica L.; Kaakinen, Marika; Rodriguez, Alina; Sebert, Sylvain; Vaarasmaki, Marja; Lakka, Timo; Lindi, Virpi; Gehring, Ulrike; Postma, Dirkje S.; Ang, Wei; Newnham, John P.; Lyytikainen, Leo-Pekka; Pahkala, Katja; Raitakari, Olli T.; Panoutsopoulou, Kalliope; Zeggini, Eleftheria; Boomsma, Dorret I.; Groen-Blokhuis, Maria; Ilonen, Jorma; Franke, Lude; Hirschhorn, Joel N.; Pers, Tune H.; Liang, Liming; Huang, Jinyan; Hocher, Berthold; Knip, Mikael; Saw, Seang-Mei; Holloway, John W.; Melen, Erik; Grant, Struan F. A.; Feenstra, Bjarke; Lowe, William L.; Widen, Elisabeth; Sergeyev, Elena; Grallert, Harald; Custovic, Adnan; Jacobsson, Bo; Jarvelin, Marjo-Riitta; Atalay, Mustafa; Koppelman, Gerard H.; Pennell, Craig E.; Niinikoski, Harri; Dedoussis, George V.; Mccarthy, Mark I.; Frayling, Timothy M.; Sunyer, Jordi; Timpson, Nicholas J.; Rivadeneira, Fernando; Bonnelykke, Klaus; Jaddoe, Vincent W. V. A novel common variant in DCST2 is associated with length in early life and height in adulthood Common genetic variants have been identified for adult height, but not much is known about the genetics of skeletal growth in early life. To identify common genetic variants that influence fetal skeletal growth, we meta-analyzed 22 genome-wide association studies (Stage 1; N = 28 459). We identified seven independent top single nucleotide polymorphisms (SNPs) (P < 1 x 10(-6)) for birth length, of which three were novel and four were in or near loci known to be associated with adult height (LCORL, PTCH1, GPR126 and HMGA2). The three novel SNPs were followed-up in nine replication studies (Stage 2; N = 11 995), with rs905938 in DC-STAMP domain containing 2 (DCST2) genome-wide significantly associated with birth length in a joint analysis (Stages 1 + 2; beta = 0.046, SE = 0.008, P = 2.46 x 10(-8), explained variance = 0.05%). Rs905938 was also associated with infant length (N = 28 228; P = 5.54 x 10(-4)) and adult height (N = 127 513; P = 1.45 x 10(-5)). DCST2 is a DC-STAMP-like protein family member and DC-STAMP is an osteoclast cell-fusion regulator. Polygenic scores based on 180 SNPs previously associated with human adult stature explained 0.13% of variance in birth length. The same SNPs explained 2.95% of the variance of infant length. Of the 180 known adult height loci, 11 were genome-wide significantly associated with infant length (SF3B4, LCORL, SPAG17, C6orf173, PTCH1, GDF5, ZNFX1, HHIP, ACAN, HLA locus and HMGA2). This study highlights that common variation in DCST2 influences variation in early growth and adult height. Oxford Oxford Univ. Press 2015 14 Human molecular genetics 24 4 1155 1168 10.1093/hmg/ddu510 Institut für Ernährungswissenschaft