Dokument-ID Dokumenttyp Verfasser/Autoren Herausgeber Haupttitel Abstract Auflage Verlagsort Verlag Erscheinungsjahr Seitenzahl Schriftenreihe Titel Schriftenreihe Bandzahl ISBN Quelle der Hochschulschrift Konferenzname Quelle:Titel Quelle:Jahrgang Quelle:Heftnummer Quelle:Erste Seite Quelle:Letzte Seite URN DOI Abteilungen OPUS4-35934 Wissenschaftlicher Artikel Taal, H. Rob; St Pourcain, Beate; Thiering, Elisabeth; Das, Shikta; Mook-Kanamori, Dennis O.; Warrington, Nicole M.; Kaakinen, Marika; Kreiner-Moller, Eskil; Bradfield, Jonathan P.; Freathy, Rachel M.; Geller, Frank; Guxens, Monica; Cousminer, Diana L.; Kerkhof, Marjan; Timpson, Nicholas J.; Ikram, M. Arfan; Beilin, Lawrence J.; Bonnelykke, Klaus; Buxton, Jessica L.; Charoen, Pimphen; Chawes, Bo Lund Krogsgaard; Eriksson, Johan; Evans, David M.; Hofman, Albert; Kemp, John P.; Kim, Cecilia E.; Klopp, Norman; Lahti, Jari; Lye, Stephen J.; McMahon, George; Mentch, Frank D.; Mueller-Nurasyid, Martina; O'Reilly, Paul F.; Prokopenko, Inga; Rivadeneira, Fernando; Steegers, Eric A. P.; Sunyer, Jordi; Tiesler, Carla; Yaghootkar, Hanieh; Breteler, Monique M. B.; Debette, Stephanie; Fornage, Myriam; Gudnason, Vilmundur; Launer, Lenore J.; van der Lugt, Aad; Mosley, Thomas H.; Seshadri, Sudha; Smith, Albert V.; Vernooij, Meike W.; Blakemore, Alexandra I. F.; Chiavacci, Rosetta M.; Feenstra, Bjarke; Fernandez-Banet, Julio; Grant, Struan F. A.; Hartikainen, Anna-Liisa; van der Heijden, Albert J.; Iniguez, Carmen; Lathrop, Mark; McArdle, Wendy L.; Molgaard, Anne; Newnham, John P.; Palmer, Lyle J.; Palotie, Aarno; Pouta, Annneli; Ring, Susan M.; Sovio, Ulla; Standl, Marie; Uitterlinden, Andre G.; Wichmann, H-Erich; Vissing, Nadja Hawwa; DeCarli, Charles; van Duijn, Cornelia M.; McCarthy, Mark I.; Koppelman, Gerard H.; Estivill, Xavier; Hattersley, Andrew T.; Melbye, Mads; Bisgaard, Hans; Pennell, Craig E.; Widen, Elisabeth; Hakonarson, Hakon; Smith, George Davey; Heinrich, Joachim; Jarvelin, Marjo-Riitta; Jaddoe, Vincent W. V.; Adair, Linda S.; Ang, Wei; Atalay, Mustafa; van Beijsterveldt, Toos; Bergen, Nienke; Benke, Kelly; Berry, Diane J.; Bradfield, Jonathan P.; Charoen, Pimphen; Coin, Lachlan; Cousminer, Diana L.; Das, Shikta; Davis, Oliver S. P.; Elliott, Paul; Evans, David M.; Feenstra, Bjarke; Flexeder, Claudia; Frayling, Tim; Freathy, Rachel M.; Gaillard, Romy; Geller, Frank; Groen-Blokhuis, Maria; Goh, Liang-Kee; Guxens, Monica; Haworth, Claire M. A.; Hadley, Dexter; Hebebrand, Johannes; Hinney, Anke; Hirschhorn, Joel N.; Holloway, John W.; Holst, Claus; Hottenga, Jouke Jan; Horikoshi, Momoko; Huikari, Ville; Hypponen, Elina; Iniguez, Carmen; Kaakinen, Marika; Kilpelainen, Tuomas O.; Kirin, Mirna; Kowgier, Matthew; Lakka, Hanna-Maaria; Lange, Leslie A.; Lawlor, Debbie A.; Lehtimaki, Terho; Lewin, Alex; Lindgren, Cecilia; Lindi, Virpi; Maggi, Reedik; Marsh, Julie; Middeldorp, Christel; Millwood, Iona; Mook-Kanamori, Dennis O.; Murray, Jeffrey C.; Nivard, Michel; Nohr, Ellen Aagaard; Ntalla, Ioanna; Oken, Emily; O'Reilly, Paul F.; Palmer, Lyle J.; Panoutsopoulou, Kalliope; Pararajasingham, Jennifer; Prokopenko, Inga; Rodriguez, Alina; Salem, Rany M.; Sebert, Sylvain; Siitonen, Niina; Sovio, Ulla; St Pourcain, Beate; Strachan, David P.; Sunyer, Jordi; Taal, H. Rob; Teo, Yik-Ying; Thiering, Elisabeth; Tiesler, Carla; Uitterlinden, Andre G.; Valcarcel, Beatriz; Warrington, Nicole M.; White, Scott; Willemsen, Gonneke; Yaghootkar, Hanieh; Zeggini, Eleftheria; Boomsma, Dorret I.; Cooper, Cyrus; Estivill, Xavier; Gillman, Matthew; Grant, Struan F. A.; Hakonarson, Hakon; Hattersley, Andrew T.; Heinrich, Joachim; Hocher, Berthold; Jaddoe, Vincent W. V.; Jarvelin, Marjo-Riitta; Lakka, Timo A.; McCarthy, Mark I.; Melbye, Mads; Mohlke, Karen L.; Dedoussis, George V.; Ong, Ken K.; Pearson, Ewan R.; Pennell, Craig E.; Price, Thomas S.; Power, Chris; Raitakari, Olli T.; Saw, Seang-Mei; Scherag, Andre; Simell, Olli; Sorensen, Thorkild I. A.; Timpson, Nicholas J.; Widen, Elisabeth; Wilson, James F.; Ang, Wei; van Beijsterveldt, Toos; Bergen, Nienke; Benke, Kelly; Berry, Diane J.; Bradfield, Jonathan P.; Charoen, Pimphen; Coin, Lachlan; Cousminer, Diana L.; Das, Shikta; Elliott, Paul; Evans, David M.; Frayling, Tim; Freathy, Rachel M.; Gaillard, Romy; Groen-Blokhuis, Maria; Guxens, Monica; Hadley, Dexter; Hottenga, Jouke Jan; Huikari, Ville; Hypponen, Elina; Kaakinen, Marika; Kowgier, Matthew; Lawlor, Debbie A.; Lewin, Alex; Lindgren, Cecilia; Marsh, Julie; Middeldorp, Christel; Millwood, Iona; Mook-Kanamori, Dennis O.; Nivard, Michel; O'Reilly, Paul F.; Palmer, Lyle J.; Prokopenko, Inga; Rodriguez, Alina; Sebert, Sylvain; Sovio, Ulla; St Pourcain, Beate; Standl, Marie; Strachan, David P.; Sunyer, Jordi; Taal, H. Rob; Thiering, Elisabeth; Tiesler, Carla; Uitterlinden, Andre G.; Valcarcel, Beatriz; Warrington, Nicole M.; White, Scott; Willemsen, Gonneke; Yaghootkar, Hanieh; Boomsma, Dorret I.; Estivill, Xavier; Grant, Struan F. A.; Hakonarson, Hakon; Hattersley, Andrew T.; Heinrich, Joachim; Jaddoe, Vincent W. V.; Jarvelin, Marjo-Riitta; McCarthy, Mark I.; Pennell, Craig E.; Power, Chris; Timpson, Nicholas J.; Widen, Elisabeth; Ikram, M. Arfan; Fornage, Myriam; Smith, Albert V.; Seshadri, Sudha; Schmidt, Reinhold; Debette, Stephanie; Vrooman, Henri A.; Sigurdsson, Sigurdur; Ropele, Stefan; Coker, Laura H.; Longstreth, W. T.; Niessen, Wiro J.; DeStefano, Anita L.; Beiser, Alexa; Zijdenbos, Alex P.; Struchalin, Maksim; Jack, Clifford R.; Nalls, Mike A.; Au, Rhoda; Hofman, Albert; Gudnason, Haukur; van der Lugt, Aad; Harris, Tamara B.; Meeks, William M.; Vernooij, Meike W.; van Buchem, Mark A.; Catellier, Diane; Gudnason, Vilmundur; Windham, B. Gwen; Wolf, Philip A.; van Duijn, Cornelia M.; Mosley, Thomas H.; Schmidt, Helena; Launer, Lenore J.; Breteler, Monique M. B.; DeCarli, Charles Common variants at 12q15 and 12q24 are associated with infant head circumference To identify genetic variants associated with head circumference in infancy, we performed a meta-analysis of seven genome-wide association studies (GWAS) (N = 10,768 individuals of European ancestry enrolled in pregnancy and/or birth cohorts) and followed up three lead signals in six replication studies (combined N = 19,089). rs7980687 on chromosome 12q24 (P = 8.1 x 10(-9)) and rs1042725 on chromosome 12q15 (P = 2.8 x 10(-10)) were robustly associated with head circumference in infancy. Although these loci have previously been associated with adult height(1), their effects on infant head circumference were largely independent of height (P = 3.8 x 10(-7) for rs7980687 and P = 1.3 x 10(-7) for rs1042725 after adjustment for infant height). A third signal, rs11655470 on chromosome 17q21, showed suggestive evidence of association with head circumference (P = 3.9 x 10(-6)). SNPs correlated to the 17q21 signal have shown genome-wide association with adult intracranial volume(2), Parkinson's disease and other neurodegenerative diseases(3-5), indicating that a common genetic variant in this region might link early brain growth with neurological disease in later life. New York Nature Publ. Group 2012 9 Nature genetics 44 5 532 + 10.1038/ng.2238 Institut für Biochemie und Biologie