@article{IhdePufahlVoelkeretal.2022, author = {Ihde, Sven and Pufahl, Luise and V{\"o}lker, Maximilian and Goel, Asvin and Weske, Mathias}, title = {A framework for modeling and executing task}, series = {Computing : archives for informatics and numerical computation}, volume = {104}, journal = {Computing : archives for informatics and numerical computation}, publisher = {Springer}, address = {Wien}, issn = {0010-485X}, doi = {10.1007/s00607-022-01093-2}, pages = {2405 -- 2429}, year = {2022}, abstract = {As resources are valuable assets, organizations have to decide which resources to allocate to business process tasks in a way that the process is executed not only effectively but also efficiently. Traditional role-based resource allocation leads to effective process executions, since each task is performed by a resource that has the required skills and competencies to do so. However, the resulting allocations are typically not as efficient as they could be, since optimization techniques have yet to find their way in traditional business process management scenarios. On the other hand, operations research provides a rich set of analytical methods for supporting problem-specific decisions on resource allocation. This paper provides a novel framework for creating transparency on existing tasks and resources, supporting individualized allocations for each activity in a process, and the possibility to integrate problem-specific analytical methods of the operations research domain. To validate the framework, the paper reports on the design and prototypical implementation of a software architecture, which extends a traditional process engine with a dedicated resource management component. This component allows us to define specific resource allocation problems at design time, and it also facilitates optimized resource allocation at run time. The framework is evaluated using a real-world parcel delivery process. The evaluation shows that the quality of the allocation results increase significantly with a technique from operations research in contrast to the traditional applied rule-based approach.}, language = {en} } @article{LangenhanJaegerBaumetal.2022, author = {Langenhan, Jennifer and Jaeger, Carsten and Baum, Katharina and Simon, Mareike and Lisec, Jan}, title = {A flexible tool to correct superimposed mass isotopologue distributions in GC-APCI-MS flux experiments}, series = {Metabolites}, volume = {12}, journal = {Metabolites}, number = {5}, publisher = {MDPI}, address = {Basel}, issn = {2218-1989}, doi = {10.3390/metabo12050408}, pages = {10}, year = {2022}, abstract = {The investigation of metabolic fluxes and metabolite distributions within cells by means of tracer molecules is a valuable tool to unravel the complexity of biological systems. Technological advances in mass spectrometry (MS) technology such as atmospheric pressure chemical ionization (APCI) coupled with high resolution (HR), not only allows for highly sensitive analyses but also broadens the usefulness of tracer-based experiments, as interesting signals can be annotated de novo when not yet present in a compound library. However, several effects in the APCI ion source, i.e., fragmentation and rearrangement, lead to superimposed mass isotopologue distributions (MID) within the mass spectra, which need to be corrected during data evaluation as they will impair enrichment calculation otherwise. Here, we present and evaluate a novel software tool to automatically perform such corrections. We discuss the different effects, explain the implemented algorithm, and show its application on several experimental datasets. This adjustable tool is available as an R package from CRAN.}, language = {en} } @article{HaslVoelkleKretschmannetal.2022, author = {Hasl, Andrea and Voelkle, Manuel and Kretschmann, Julia and Richter, Dirk and Brunner, Martin}, title = {A dynamic structural equation approach to modeling wage dynamics and cumulative advantage across the lifespan}, series = {Multivariate Behavioral Research}, volume = {58}, journal = {Multivariate Behavioral Research}, number = {3}, publisher = {Routledge, Taylor \& Francis Group}, address = {Abingdon}, issn = {0027-3171}, doi = {10.1080/00273171.2022.2029339}, pages = {504 -- 525}, year = {2022}, abstract = {Wages and wage dynamics directly affect individuals' and families' daily lives. In this article, we show how major theoretical branches of research on wages and inequality-that is, cumulative advantage (CA), human capital theory, and the lifespan perspective-can be integrated into a coherent statistical framework and analyzed with multilevel dynamic structural equation modeling (DSEM). This opens up a new way to empirically investigate the mechanisms that drive growing inequality over time. We demonstrate the new approach by making use of longitudinal, representative U.S. data (NLSY-79). Analyses revealed fundamental between-person differences in both initial wages and autoregressive wage growth rates across the lifespan. Only 0.5\% of the sample experienced a "strict" CA and unbounded wage growth, whereas most individuals revealed logarithmic wage growth over time. Adolescent intelligence and adult educational levels explained substantial heterogeneity in both parameters. We discuss how DSEM may help researchers study CA processes and related developmental dynamics, and we highlight the extensions and limitations of the DSEM framework.}, language = {en} } @article{ReifarthBekirBapolisietal.2022, author = {Reifarth, Martin and Bekir, Marek and Bapolisi, Alain M. and Titov, Evgenii and Nusshardt, Fabian and Nowaczyk, Julius and Grigoriev, Dmitry and Sharma, Anjali and Saalfrank, Peter and Santer, Svetlana and Hartlieb, Matthias and B{\"o}ker, Alexander}, title = {A dual pH- and light-responsive spiropyrane-based surfactant}, series = {Angewandte Chemie : a journal of the Gesellschaft Deutscher Chemiker ; International edition}, volume = {61}, journal = {Angewandte Chemie : a journal of the Gesellschaft Deutscher Chemiker ; International edition}, number = {21}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1433-7851}, doi = {10.1002/anie.202114687}, pages = {10}, year = {2022}, abstract = {A cationic surfactant containing a spiropyrane unit is prepared exhibiting a dual-responsive adjustability of its surface-active characteristics. The switching mechanism of the system relies on the reversible conversion of the non-ionic spiropyrane (SP) to a zwitterionic merocyanine (MC) and can be controlled by adjusting the pH value and via light, resulting in a pH-dependent photoactivity: While the compound possesses a pronounced difference in surface activity between both forms under acidic conditions, this behavior is suppressed at a neutral pH level. The underlying switching processes are investigated in detail, and a thermodynamic explanation based on a combination of theoretical and experimental results is provided. This complex stimuli-responsive behavior enables remote-control of colloidal systems. To demonstrate its applicability, the surfactant is utilized for the pH-dependent manipulation of oil-in-water emulsions.}, language = {en} } @article{Schenck2022, author = {Schenck, Marcia C.}, title = {A different class of refugee: university scholarships and developmentalism in late 1960s Africa}, series = {Africa Today}, volume = {69}, journal = {Africa Today}, number = {1-2}, editor = {Schenck, Marcia C. and Njung, George N.}, publisher = {Indiana Univ. Press}, address = {Bloomington}, issn = {1527-1978}, doi = {10.2979/africatoday.69.1_2.07}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-569066}, pages = {134 -- 161}, year = {2022}, abstract = {Using documents assembled in connection with the 1967 Conference on the Legal, Economic and Social Aspects of African Refugee Problems, this article discusses African refugee higher-education discourses in the 1960s at the level of international organizations, volunteer agencies, and government representatives. Education and development history have recently been studied together, but this article focuses on the history of refugee higher education, which, it argues, needs to be understood within the development framework of human-capital theory, meant to support political pan African concerns for a decolonized continent and merged with humanitarian arguments to create a hybrid form of humanitarian developmentalism. The article zooms in on higher-education scholarships, above all for refugees from Southern Africa, as a means of support for human-capital development. It shows that refugee higher education was both a result and a driver of increased international exchanges, as evidenced at the 1967 conference.}, language = {en} } @article{AndjelkovicSimevskiChenetal.2022, author = {Andjelkovic, Marko and Simevski, Aleksandar and Chen, Junchao and Schrape, Oliver and Stamenkovic, Zoran and Krstić, Miloš and Ilic, Stefan and Ristic, Goran and Jaksic, Aleksandar and Vasovic, Nikola and Duane, Russell and Palma, Alberto J. and Lallena, Antonio M. and Carvajal, Miguel A.}, title = {A design concept for radiation hardened RADFET readout system for space applications}, series = {Microprocessors and microsystems}, volume = {90}, journal = {Microprocessors and microsystems}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0141-9331}, doi = {10.1016/j.micpro.2022.104486}, pages = {18}, year = {2022}, abstract = {Instruments for measuring the absorbed dose and dose rate under radiation exposure, known as radiation dosimeters, are indispensable in space missions. They are composed of radiation sensors that generate current or voltage response when exposed to ionizing radiation, and processing electronics for computing the absorbed dose and dose rate. Among a wide range of existing radiation sensors, the Radiation Sensitive Field Effect Transistors (RADFETs) have unique advantages for absorbed dose measurement, and a proven record of successful exploitation in space missions. It has been shown that the RADFETs may be also used for the dose rate monitoring. In that regard, we propose a unique design concept that supports the simultaneous operation of a single RADFET as absorbed dose and dose rate monitor. This enables to reduce the cost of implementation, since the need for other types of radiation sensors can be minimized or eliminated. For processing the RADFET's response we propose a readout system composed of analog signal conditioner (ASC) and a self-adaptive multiprocessing system-on-chip (MPSoC). The soft error rate of MPSoC is monitored in real time with embedded sensors, allowing the autonomous switching between three operating modes (high-performance, de-stress and fault-tolerant), according to the application requirements and radiation conditions.}, language = {en} } @phdthesis{Mertzen2022, author = {Mertzen, Daniela}, title = {A cross-linguistic investigation of similarity-based interference in sentence comprehension}, doi = {10.25932/publishup-55668}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-556685}, school = {Universit{\"a}t Potsdam}, pages = {xvii, 129}, year = {2022}, abstract = {The aim of this dissertation was to conduct a larger-scale cross-linguistic empirical investigation of similarity-based interference effects in sentence comprehension. Interference studies can offer valuable insights into the mechanisms that are involved in long-distance dependency completion. Many studies have investigated similarity-based interference effects, showing that syntactic and semantic information are employed during long-distance dependency formation (e.g., Arnett \& Wagers, 2017; Cunnings \& Sturt, 2018; Van Dyke, 2007, Van Dyke \& Lewis, 2003; Van Dyke \& McElree, 2011). Nevertheless, there are some important open questions in the interference literature that are critical to our understanding of the constraints involved in dependency resolution. The first research question concerns the relative timing of syntactic and semantic interference in online sentence comprehension. Only few interference studies have investigated this question, and, to date, there is not enough data to draw conclusions with regard to their time course (Van Dyke, 2007; Van Dyke \& McElree, 2011). Our first cross-linguistic study explores the relative timing of syntactic and semantic interference in two eye-tracking reading experiments that implement the study design used in Van Dyke (2007). The first experiment tests English sentences. The second, larger-sample experiment investigates the two interference types in German. Overall, the data suggest that syntactic and semantic interference can arise simultaneously during retrieval. The second research question concerns a special case of semantic interference: We investigate whether cue-based retrieval interference can be caused by semantically similar items which are not embedded in a syntactic structure. This second interference study builds on a landmark study by Van Dyke \& McElree (2006). The study design used in their study is unique in that it is able to pin down the source of interference as a consequence of cue overload during retrieval, when semantic retrieval cues do not uniquely match the retrieval target. Unlike most other interference studies, this design is able to rule out encoding interference as an alternative explanation. Encoding accounts postulate that it is not cue overload at the retrieval site but the erroneous encoding of similar linguistic items in memory that leads to interference (Lewandowsky et al., 2008; Oberauer \& Kliegl, 2006). While Van Dyke \& McElree (2006) reported cue-based retrieval interference from sentence-external distractors, the evidence for this effect was weak. A subsequent study did not show interference of this type (Van Dyke et al., 2014). Given these inconclusive findings, further research is necessary to investigate semantic cue-based retrieval interference. The second study in this dissertation provides a larger-scale cross-linguistic investigation of cue-based retrieval interference from sentence-external items. Three larger-sample eye-tracking studies in English, German, and Russian tested cue-based interference in the online processing of filler-gap dependencies. This study further extends the previous research by investigating interference in each language under varying task demands (Logačev \& Vasishth, 2016; Swets et al., 2008). Overall, we see some very modest support for proactive cue-based retrieval interference in English. Unexpectedly, this was observed only under a low task demand. In German and Russian, there is some evidence against the interference effect. It is possible that interference is attenuated in languages with richer case marking. In sum, the cross-linguistic experiments on the time course of syntactic and semantic interference from sentence-internal distractors support existing evidence of syntactic and semantic interference during sentence comprehension. Our data further show that both types of interference effects can arise simultaneously. Our cross-linguistic experiments investigating semantic cue-based retrieval interference from sentence-external distractors suggest that this type of interference may arise only in specific linguistic contexts.}, language = {en} } @article{Buerger2022, author = {B{\"u}rger, Gerd}, title = {A conundrum of trends}, series = {Journal of hydrology}, volume = {609}, journal = {Journal of hydrology}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0022-1694}, doi = {10.1016/j.jhydrol.2022.127745}, pages = {3}, year = {2022}, abstract = {This comment is meant to reiterate two warnings: One applies to the uncritical use of ready-made (openly available) program packages, and one to the estimation of trends in serially correlated time series. Both warnings apply to the recent publication of Lischeid et al. about lake-level trends in Germany.}, language = {en} } @article{MaierWiljesHartungetal.2022, author = {Maier, Corinna Sabrina and Wiljes, Jana de and Hartung, Niklas and Kloft, Charlotte and Huisinga, Wilhelm}, title = {A continued learning approach for model-informed precision dosing}, series = {CPT: pharmacometrics \& systems pharmacology}, volume = {11}, journal = {CPT: pharmacometrics \& systems pharmacology}, number = {2}, publisher = {London}, address = {Nature Publ. Group}, issn = {2163-8306}, doi = {10.1002/psp4.12745}, pages = {185 -- 198}, year = {2022}, abstract = {Model-informed precision dosing (MIPD) is a quantitative dosing framework that combines prior knowledge on the drug-disease-patient system with patient data from therapeutic drug/ biomarker monitoring (TDM) to support individualized dosing in ongoing treatment. Structural models and prior parameter distributions used in MIPD approaches typically build on prior clinical trials that involve only a limited number of patients selected according to some exclusion/inclusion criteria. Compared to the prior clinical trial population, the patient population in clinical practice can be expected to also include altered behavior and/or increased interindividual variability, the extent of which, however, is typically unknown. Here, we address the question of how to adapt and refine models on the level of the model parameters to better reflect this real-world diversity. We propose an approach for continued learning across patients during MIPD using a sequential hierarchical Bayesian framework. The approach builds on two stages to separate the update of the individual patient parameters from updating the population parameters. Consequently, it enables continued learning across hospitals or study centers, because only summary patient data (on the level of model parameters) need to be shared, but no individual TDM data. We illustrate this continued learning approach with neutrophil-guided dosing of paclitaxel. The present study constitutes an important step toward building confidence in MIPD and eventually establishing MIPD increasingly in everyday therapeutic use.}, language = {en} } @article{StaufferMengeshaSeifertetal.2022, author = {Stauffer, Maxime and Mengesha, Isaak and Seifert, Konrad and Krawczuk, Igor and Fischer, Jens and Serugendo, Giovanna Di Marzo}, title = {A computational turn in policy process studies}, series = {Complexity}, volume = {2022}, journal = {Complexity}, publisher = {Wiley-Hindawi}, address = {London}, issn = {1076-2787}, doi = {10.1155/2022/8210732}, pages = {17}, year = {2022}, abstract = {The past three decades of policy process studies have seen the emergence of a clear intellectual lineage with regard to complexity. Implicitly or explicitly, scholars have employed complexity theory to examine the intricate dynamics of collective action in political contexts. However, the methodological counterparts to complexity theory, such as computational methods, are rarely used and, even if they are, they are often detached from established policy process theory. Building on a critical review of the application of complexity theory to policy process studies, we present and implement a baseline model of policy processes using the logic of coevolving networks. Our model suggests that an actor's influence depends on their environment and on exogenous events facilitating dialogue and consensus-building. Our results validate previous opinion dynamics models and generate novel patterns. Our discussion provides ground for further research and outlines the path for the field to achieve a computational turn.}, language = {en} }