@article{Brandenburger2022, author = {Brandenburger, Bonny}, title = {A multidimensional and analytical perspective on Open Educational Practices in the 21st century}, series = {Frontiers in education}, volume = {7}, journal = {Frontiers in education}, publisher = {Frontiers Media}, address = {Lausanne}, issn = {2504-284X}, doi = {10.3389/feduc.2022.990675}, pages = {17}, year = {2022}, abstract = {Participatory approaches to teaching and learning are experiencing a new lease on life in the 21st century as a result of the rapid technology development. Knowledge, practices, and tools can be shared across spatial and temporal boundaries in higher education by means of Open Educational Resources, Massive Open Online Courses, and open-source technologies. In this context, the Open Education Movement calls for new didactic approaches that encourage greater learner participation in formal higher education. Based on a representative literature review and focus group research, in this study an analytical framework was developed that enables researchers and practitioners to assess the form of participation in formal, collaborative teaching and learning practices. The analytical framework is focused on the micro-level of higher education, in particular on the interaction between students and lecturers when organizing the curriculum. For this purpose, the research reflects anew on the concept of participation, taking into account existing stage models for participation in the educational context. These are then brought together with the dimensions of teaching and learning processes, such as methods, objectives and content, etc. This paper aims to make a valuable contribution to the opening up of learning and teaching, and expands the discourse around possibilities for interpreting Open Educational Practices.}, language = {en} } @misc{Brandenburger2022, author = {Brandenburger, Bonny}, title = {A multidimensional and analytical perspective on Open Educational Practices in the 21st century}, series = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Wirtschaft- und Sozialwissenschaftliche Reihe}, journal = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Wirtschaft- und Sozialwissenschaftliche Reihe}, number = {157}, issn = {1867-5808}, doi = {10.25932/publishup-58777}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-587770}, pages = {17}, year = {2022}, abstract = {Participatory approaches to teaching and learning are experiencing a new lease on life in the 21st century as a result of the rapid technology development. Knowledge, practices, and tools can be shared across spatial and temporal boundaries in higher education by means of Open Educational Resources, Massive Open Online Courses, and open-source technologies. In this context, the Open Education Movement calls for new didactic approaches that encourage greater learner participation in formal higher education. Based on a representative literature review and focus group research, in this study an analytical framework was developed that enables researchers and practitioners to assess the form of participation in formal, collaborative teaching and learning practices. The analytical framework is focused on the micro-level of higher education, in particular on the interaction between students and lecturers when organizing the curriculum. For this purpose, the research reflects anew on the concept of participation, taking into account existing stage models for participation in the educational context. These are then brought together with the dimensions of teaching and learning processes, such as methods, objectives and content, etc. This paper aims to make a valuable contribution to the opening up of learning and teaching, and expands the discourse around possibilities for interpreting Open Educational Practices.}, language = {en} } @article{HassaninKliemSeehaferetal.2022, author = {Hassanin, Alshaimaa and Kliem, Bernhard and Seehafer, Norbert and T{\"o}r{\"o}k, Tibor}, title = {A model of homologous confined and ejective eruptions involving kink instability and flux cancellation}, series = {The astrophysical journal : an international review of spectroscopy and astronomical physics}, volume = {929}, journal = {The astrophysical journal : an international review of spectroscopy and astronomical physics}, number = {2}, publisher = {IOP Publ. Ltd.}, address = {Bristol}, issn = {2041-8205}, doi = {10.3847/2041-8213/ac64a9}, pages = {7}, year = {2022}, abstract = {In this study, we model a sequence of a confined and a full eruption, employing the relaxed end state of the confined eruption of a kink-unstable flux rope as the initial condition for the ejective one. The full eruption, a model of a coronal mass ejection, develops as a result of converging motions imposed at the photospheric boundary, which drive flux cancellation. In this process, parts of the positive and negative external flux converge toward the polarity inversion line, reconnect, and cancel each other. Flux of the same amount as the canceled flux transfers to a flux rope, increasing the free magnetic energy of the coronal field. With sustained flux cancellation and the associated progressive weakening of the magnetic tension of the overlying flux, we find that a flux reduction of approximate to 11\% initiates the torus instability of the flux rope, which leads to a full eruption. These results demonstrate that a homologous full eruption, following a confined one, can be driven by flux cancellation.}, language = {en} } @phdthesis{Gerling2022, author = {Gerling, Marten Tobias}, title = {A microfluidic system for high-precision image-based live cell sorting using dielectrophoretic forces}, doi = {10.25932/publishup-58742}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-587421}, school = {Universit{\"a}t Potsdam}, pages = {vii, 87, VI}, year = {2022}, abstract = {An important goal in biotechnology and (bio-) medical research is the isolation of single cells from a heterogeneous cell population. These specialised cells are of great interest for bioproduction, diagnostics, drug development, (cancer) therapy and research. To tackle emerging questions, an ever finer differentiation between target cells and non-target cells is required. This precise differentiation is a challenge for a growing number of available methods. Since the physiological properties of the cells are closely linked to their morphology, it is beneficial to include their appearance in the sorting decision. For established methods, this represents a non addressable parameter, requiring new methods for the identification and isolation of target cells. Consequently, a variety of new flow-based methods have been developed and presented in recent years utilising 2D imaging data to identify target cells within a sample. As these methods aim for high throughput, the devices developed typically require highly complex fluid handling techniques, making them expensive while offering limited image quality. In this work, a new continuous flow system for image-based cell sorting was developed that uses dielectrophoresis to precisely handle cells in a microchannel. Dielectrophoretic forces are exerted by inhomogeneous alternating electric fields on polarisable particles (here: cells). In the present system, the electric fields can be switched on and off precisely and quickly by a signal generator. In addition to the resulting simple and effective cell handling, the system is characterised by the outstanding quality of the image data generated and its compatibility with standard microscopes. These aspects result in low complexity, making it both affordable and user-friendly. With the developed cell sorting system, cells could be sorted reliably and efficiently according to their cytosolic staining as well as morphological properties at different optical magnifications. The achieved purity of the target cell population was up to 95\% and about 85\% of the sorted cells could be recovered from the system. Good agreement was achieved between the results obtained and theoretical considerations. The achieved throughput of the system was up to 12,000 cells per hour. Cell viability studies indicated a high biocompatibility of the system. The results presented demonstrate the potential of image-based cell sorting using dielectrophoresis. The outstanding image quality and highly precise yet gentle handling of the cells set the system apart from other technologies. This results in enormous potential for processing valuable and sensitive cell samples.}, language = {en} } @article{dePaulaMarxWolfetal.2022, author = {de Paula, Danielly and Marx, Carolin and Wolf, Ella and Dremel, Christian and Cormican, Kathryn and Uebernickel, Falk}, title = {A managerial mental model to drive innovation in the context of digital transformation}, series = {Industry and innovation}, journal = {Industry and innovation}, publisher = {Routledge, Taylor \& Francis Group}, address = {Abingdon}, issn = {1366-2716}, doi = {10.1080/13662716.2022.2072711}, pages = {24}, year = {2022}, abstract = {Industry 4.0 is transforming how businesses innovate and, as a result, companies are spearheading the movement towards 'Digital Transformation'. While some scholars advocate the use of design thinking to identify new innovative behaviours, cognition experts emphasise the importance of top managers in supporting employees to develop these behaviours. However, there is a dearth of research in this domain and companies are struggling to implement the required behaviours. To address this gap, this study aims to identify and prioritise behavioural strategies conducive to design thinking to inform the creation of a managerial mental model. We identify 20 behavioural strategies from 45 interviewees with practitioners and educators and combine them with the concepts of 'paradigm-mindset-mental model' from cognition theory. The paper contributes to the body of knowledge by identifying and prioritising specific behavioural strategies to form a novel set of survival conditions aligned to the new industrial paradigm of Industry 4.0.}, language = {en} } @article{HeroldLabottGraessleretal.2022, author = {Herold, Fabian and Labott, Berit K. and Gr{\"a}ssler, Bernhard and Halfpaap, Nicole and Langhans, Corinna and M{\"u}ller, Patrick and Ammar, Achraf and Dordevic, Milos and H{\"o}kelmann, Anita and M{\"u}ller, Notger Germar}, title = {A Link between Handgrip Strength and Executive Functioning: A Cross-Sectional Study in Older Adults with Mild Cognitive Impairment and Healthy Controls}, series = {Healthcare : open access journal}, volume = {10}, journal = {Healthcare : open access journal}, edition = {2}, publisher = {MDPI}, address = {Basel, Schweiz}, issn = {2227-9032}, doi = {10.3390/healthcare10020230}, pages = {1 -- 14}, year = {2022}, abstract = {Older adults with amnestic mild cognitive impairment (aMCI) who in addition to their memory deficits also suffer from frontal-executive dysfunctions have a higher risk of developing dementia later in their lives than older adults with aMCI without executive deficits and older adults with non-amnestic MCI (naMCI). Handgrip strength (HGS) is also correlated with the risk of cognitive decline in the elderly. Hence, the current study aimed to investigate the associations between HGS and executive functioning in individuals with aMCI, naMCI and healthy controls. Older, right-handed adults with amnestic MCI (aMCI), non-amnestic MCI (naMCI), and healthy controls (HC) conducted a handgrip strength measurement via a handheld dynamometer. Executive functions were assessed with the Trail Making Test (TMT A\&B). Normalized handgrip strength (nHGS, normalized to Body Mass Index (BMI)) was calculated and its associations with executive functions (operationalized through z-scores of TMT B/A ratio) were investigated through partial correlation analyses (i.e., accounting for age, sex, and severity of depressive symptoms). A positive and low-to-moderate correlation between right nHGS (rp (22) = 0.364; p = 0.063) and left nHGS (rp (22) = 0.420; p = 0.037) and executive functioning in older adults with aMCI but not in naMCI or HC was observed. Our results suggest that higher levels of nHGS are linked to better executive functioning in aMCI but not naMCI and HC. This relationship is perhaps driven by alterations in the integrity of the hippocampal-prefrontal network occurring in older adults with aMCI. Further research is needed to provide empirical evidence for this assumption.}, language = {en} } @misc{HeroldLabottGraessleretal.2022, author = {Herold, Fabian and Labott, Berit K. and Gr{\"a}ssler, Bernhard and Halfpaap, Nicole and Langhans, Corinna and M{\"u}ller, Patrick and Ammar, Achraf and Dordevic, Milos and H{\"o}kelmann, Anita and M{\"u}ller, Notger Germar}, title = {A Link between Handgrip Strength and Executive Functioning: A Cross-Sectional Study in Older Adults with Mild Cognitive Impairment and Healthy Controls}, series = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe}, journal = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1866-8364}, doi = {10.25932/publishup-55925}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-559251}, pages = {1 -- 14}, year = {2022}, abstract = {Older adults with amnestic mild cognitive impairment (aMCI) who in addition to their memory deficits also suffer from frontal-executive dysfunctions have a higher risk of developing dementia later in their lives than older adults with aMCI without executive deficits and older adults with non-amnestic MCI (naMCI). Handgrip strength (HGS) is also correlated with the risk of cognitive decline in the elderly. Hence, the current study aimed to investigate the associations between HGS and executive functioning in individuals with aMCI, naMCI and healthy controls. Older, right-handed adults with amnestic MCI (aMCI), non-amnestic MCI (naMCI), and healthy controls (HC) conducted a handgrip strength measurement via a handheld dynamometer. Executive functions were assessed with the Trail Making Test (TMT A\&B). Normalized handgrip strength (nHGS, normalized to Body Mass Index (BMI)) was calculated and its associations with executive functions (operationalized through z-scores of TMT B/A ratio) were investigated through partial correlation analyses (i.e., accounting for age, sex, and severity of depressive symptoms). A positive and low-to-moderate correlation between right nHGS (rp (22) = 0.364; p = 0.063) and left nHGS (rp (22) = 0.420; p = 0.037) and executive functioning in older adults with aMCI but not in naMCI or HC was observed. Our results suggest that higher levels of nHGS are linked to better executive functioning in aMCI but not naMCI and HC. This relationship is perhaps driven by alterations in the integrity of the hippocampal-prefrontal network occurring in older adults with aMCI. Further research is needed to provide empirical evidence for this assumption.}, language = {en} } @techreport{GiotopoulosKritikosTsakanikas2022, type = {Working Paper}, author = {Giotopoulos, Ioannis and Kritikos, Alexander and Tsakanikas, Aggelos}, title = {A Lasting Crisis affects R\&D decisions of smaller firms}, series = {CEPA Discussion Papers}, journal = {CEPA Discussion Papers}, number = {49}, issn = {2628-653X}, doi = {10.25932/publishup-55844}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-558442}, pages = {23}, year = {2022}, abstract = {We use the prolonged Greek crisis as a case study to understand how a lasting economic shock affects the innovation strategies of firms in economies with moderate innovation activities. Adopting the 3-stage CDM model, we explore the link between R\&D, innovation, and productivity for different size groups of Greek manufacturing firms during the prolonged crisis. At the first stage, we find that the continuation of the crisis is harmful for the R\&D engagement of smaller firms while it increased the willingness for R\&D activities among the larger ones. At the second stage, among smaller firms the knowledge production remains unaffected by R\&D investments, while among larger firms the R\&D decision is positively correlated with the probability of producing innovation, albeit the relationship is weakened as the crisis continues. At the third stage, innovation output benefits only larger firms in terms of labor productivity, while the innovation-productivity nexus is insignificant for smaller firms during the lasting crisis.}, language = {en} } @article{GiotopoulosKritikosTsakanikas2022, author = {Giotopoulos, Ioannis and Kritikos, Alexander and Tsakanikas, Aggelos}, title = {A lasting crisis affects R\&D decisions of smaller firms}, series = {The Journal of technology transfer}, journal = {The Journal of technology transfer}, number = {48}, publisher = {Springer Science+Business Media}, address = {Dordrecht}, issn = {0892-9912}, doi = {10.1007/s10961-022-09957-7}, pages = {1161 -- 1175}, year = {2022}, abstract = {We use the prolonged Greek crisis as a case study to understand how a lasting economic shock affects the innovation strategies of firms in economies with moderate innovation activities. Adopting the 3-stage CDM model, we explore the link between R\&D, innovation, and productivity for different size groups of Greek manufacturing firms during the prolonged crisis. At the first stage, we find that the continuation of the crisis is harmful for the R\&D engagement of smaller firms while it increased the willingness for R\&D activities among the larger ones. At the second stage, among smaller firms the knowledge production remains unaffected by R\&D investments, while among larger firms the R\&D decision is positively correlated with the probability of producing innovation, albeit the relationship is weakened as the crisis continues. At the third stage, innovation output benefits only larger firms in terms of labor productivity, while the innovation-productivity nexus is insignificant for smaller firms during the lasting crisis.}, language = {en} } @article{SvennevigHermannsKeidingetal.2022, author = {Svennevig, Kristian and Hermanns, Reginald L. and Keiding, Marie and Binder, Daniel and Citterio, Michele and Dahl-Jensen, Trine and Mertl, Stefan and S{\o}rensen, Erik Vest and Voss, Peter Henrik}, title = {A large frozen debris avalanche entraining warming permafrost ground-the June 2021 Assapaat landslibe, West Greenland}, series = {Landslides}, volume = {19}, journal = {Landslides}, publisher = {Springer}, address = {Heidelberg}, issn = {1612-510X}, doi = {10.1007/s10346-022-01922-7}, pages = {2549 -- 2567}, year = {2022}, abstract = {A large landslide (frozen debris avalanche) occurred at Assapaat on the south coast of the Nuussuaq Peninsula in Central West Greenland on June 13, 2021, at 04:04 local time. We present a compilation of available data from field observations, photos, remote sensing, and seismic monitoring to describe the event. Analysis of these data in combination with an analysis of pre- and post-failure digital elevation models results in the first description of this type of landslide. The frozen debris avalanche initiated as a 6.9 * 10(6) m(3) failure of permafrozen talus slope and underlying colluvium and till at 600-880 m elevation. It entrained a large volume of permafrozen colluvium along its 2.4 km path in two subsequent entrainment phases accumulating a total volume between 18.3 * 10(6) and 25.9 * 10(6) m(3). About 3.9 * 10(6) m(3) is estimated to have entered the Vaigat strait; however, no tsunami was reported, or is evident in the field. This is probably because the second stage of entrainment along with a flattening of slope angle reduced the mobility of the frozen debris avalanche. We hypothesise that the initial talus slope failure is dynamically conditioned by warming of the ice matrix that binds the permafrozen talus slope. When the slope ice temperature rises to a critical level, its shear resistance is reduced, resulting in an unstable talus slope prone to failure. Likewise, we attribute the large-scale entrainment to increasing slope temperature and take the frozen debris avalanche as a strong sign that the permafrost in this region is increasingly at a critical state. Global warming is enhanced in the Arctic and frequent landslide events in the past decade in Western Greenland let us hypothesise that continued warming will lead to an increase in the frequency and magnitude of these types of landslides. Essential data for critical arctic slopes such as precipitation, snowmelt, and ground and surface temperature are still missing to further test this hypothesis. It is thus strongly required that research funds are made available to better predict the change of landslide threat in the Arctic.}, language = {en} } @phdthesis{Tattarini2022, author = {Tattarini, Giulia}, title = {A job is good, but is a good job healthier?}, doi = {10.25932/publishup-53672}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-536723}, school = {Universit{\"a}t Potsdam}, pages = {182}, year = {2022}, abstract = {What are the consequences of unemployment and precarious employment for individuals' health in Europe? What are the moderating factors that may offset (or increase) the health consequences of labor-market risks? How do the effects of these risks vary across different contexts, which differ in their institutional and cultural settings? Does gender, regarded as a social structure, play a role, and how? To answer these questions is the aim of my cumulative thesis. This study aims to advance our knowledge about the health consequences that unemployment and precariousness cause over the life course. In particular, I investigate how several moderating factors, such as gender, the family, and the broader cultural and institutional context, may offset or increase the impact of employment instability and insecurity on individual health. In my first paper, 'The buffering role of the family in the relationship between job loss and self-perceived health: Longitudinal results from Europe, 2004-2011', I and my co-authors measure the causal effect of job loss on health and the role of the family and welfare states (regimes) as moderating factors. Using EU-SILC longitudinal data (2004-2011), we estimate the probability of experiencing 'bad health' following a transition to unemployment by applying linear probability models and undertake separate analyses for men and women. Firstly, we measure whether changes in the independent variable 'job loss' lead to changes in the dependent variable 'self-rated health' for men and women separately. Then, by adding into the model different interaction terms, we measure the moderating effect of the family, both in terms of emotional and economic support, and how much it varies across different welfare regimes. As an identification strategy, we first implement static fixed-effect panel models, which control for time-varying observables and indirect health selection—i.e., constant unobserved heterogeneity. Secondly, to control for reverse causality and path dependency, we implement dynamic fixed-effect panel models, adding a lagged dependent variable to the model. We explore the role of the family by focusing on close ties within households: we consider the presence of a stable partner and his/her working status as a source of social and economic support. According to previous literature, having a partner should reduce the stress from adverse events, thanks to the symbolic and emotional dimensions that such a relationship entails, regardless of any economic benefits. Our results, however, suggest that benefits linked to the presence of a (female) partner also come from the financial stability that (s)he can provide in terms of a second income. Furthermore, we find partners' employment to be at least as important as the mere presence of the partner in reducing the negative effect of job loss on the individual's health by maintaining the household's standard of living and decreasing economic strain on the family. Our results are in line with previous research, which has highlighted that some people cope better than others with adverse life circumstances, and the support provided by the family is a crucial resource in that regard. We also reported an important interaction between the family and the welfare state in moderating the health consequences of unemployment, showing how the compensation effect of the family varies across welfare regimes. The family plays a decisive role in cushioning the adverse consequences of labor market risks in Southern and Eastern welfare states, characterized by less developed social protection systems and -especially the Southern - high level of familialism. The first paper also found important gender differences concerning job loss, family and welfare effects. Of particular interest is the evidence suggesting that health selection works differently for men and women, playing a more prominent role for women than for men in explaining the relationship between job loss and self-perceived health. The second paper, 'Gender roles and selection mechanisms across contexts: A comparative analysis of the relationship between unemployment, self-perceived health, and gender.' investigates more in-depth the gender differential in health driven by unemployment. Being a highly contested issue in literature, we aim to study whether men are more penalized than women or the other way around and the mechanisms that may explain the gender difference. To do that, we rely on two theoretical arguments: the availability of alternative roles and social selection. The first argument builds on the idea that men and women may compensate for the detrimental health consequences of unemployment through the commitment to 'alternative roles,' which can provide for the resources needed to fulfill people's socially constructed needs. Notably, the availability of alternative options depends on the different positions that men and women have in society. Further, we merge the availability of the 'alternative roles' argument with the health selection argument. We assume that health selection could be contingent on people's social position as defined by gender and, thus, explain the gender differential in the relationship between unemployment and health. Ill people might be less reluctant to fall or remain (i.e., self-select) in unemployment if they have alternative roles. In Western societies, women generally have more alternative roles than men and thus more discretion in their labor market attachment. Therefore, health selection should be stronger for them, explaining why unemployment is less menace for women than for their male counterparts. Finally, relying on the idea of different gender regimes, we extended these arguments to comparison across contexts. For example, in contexts where being a caregiver is assumed to be women's traditional and primary roles and the primary breadwinner role is reserved to men, unemployment is less stigmatized, and taking up alternative roles is more socially accepted for women than for men (Hp.1). Accordingly, social (self)selection should be stronger for women than for men in traditional contexts, where, in the case of ill-health, the separation from work is eased by the availability of alternative roles (Hp.2). By focusing on contexts that are representative of different gender regimes, we implement a multiple-step comparative approach. Firstly, by using EU-SILC longitudinal data (2004-2015), our analysis tests gender roles and selection mechanisms for Sweden and Italy, representing radically different gender regimes, thus providing institutional and cultural variation. Then, we limit institutional heterogeneity by focusing on Germany and comparing East- and West-Germany and older and younger cohorts—for West-Germany (SOEP data 1995-2017). Next, to assess the differential impact of unemployment for men and women, we compared (unemployed and employed) men with (unemployed and employed) women. To do so, we calculate predicted probabilities and average marginal effect from two distinct random-effects probit models. Our first step is estimating random-effects models that assess the association between unemployment and self-perceived health, controlling for observable characteristics. In the second step, our fully adjusted model controls for both direct and indirect selection. We do this using dynamic correlated random-effects (CRE) models. Further, based on the fully adjusted model, we test our hypotheses on alternative roles (Hp.1) by comparing several contexts - models are estimated separately for each context. For this hypothesis, we pool men and women and include an interaction term between unemployment and gender, which has the advantage to allow for directly testing whether gender differences in the effect of unemployment exist and are statistically significant. Finally, we test the role of selection mechanisms (Hp.2), using the KHB method to compare coefficients across nested nonlinear models. Specifically, we test the role of selection for the relationship between unemployment and health by comparing the partially-adjusted and fully-adjusted models. To allow selection mechanisms to operate differently between genders, we estimate separate models for men and women. We found support to our first hypotheses—the context where people are embedded structures the relationship between unemployment, health, and gender. We found no gendered effect of unemployment on health in the egalitarian context of Sweden. Conversely, in the traditional context of Italy, we observed substantive and statistically significant gender differences in the effect of unemployment on bad health, with women suffering less than men. We found the same pattern for comparing East and West Germany and younger and older cohorts in West Germany. On the contrary, our results did not support our theoretical argument on social selection. We found that in Sweden, women are more selected out of employment than men. In contrast, in Italy, health selection does not seem to be the primary mechanism behind the gender differential—Italian men and women seem to be selected out of employment to the same extent. Namely, we do not find any evidence that health selection is stronger for women in more traditional countries (Hp2), despite the fact that the institutional and the cultural context would offer them a more comprehensive range of 'alternative roles' relative to men. Moreover, our second hypothesis is also rejected in the second and third comparisons, where the cross-country heterogeneity is reduced to maximize cultural differences within the same institutional context. Further research that addresses selection into inactivity is needed to evaluate the interplay between selection and social roles across gender regimes. While the health consequences of unemployment have been on the research agenda for a pretty long time, the interest in precarious employment—defined as the linking of the vulnerable worker to work that is characterized by uncertainty and insecurity concerning pay, the stability of the work arrangement, limited access to social benefits, and statutory protections—has emerged only later. Since the 80s, scholars from different disciplines have raised concerns about the social consequences of de-standardization of employment relationships. However, while work has become undoubtedly more precarious, very little is known about its causal effect on individual health and the role of gender as a moderator. These questions are at the core of my third paper : 'Bad job, bad health? A longitudinal analysis of the interaction between precariousness, gender and self-perceived health in Germany'. Herein, I investigate the multidimensional nature of precarious employment and its causal effect on health, particularly focusing on gender differences. With this paper, I aim at overcoming three major shortcomings of earlier studies: The first one regards the cross-sectional nature of data that prevents the authors from ruling out unobserved heterogeneity as a mechanism for the association between precarious employment and health. Indeed, several unmeasured individual characteristics—such as cognitive abilities—may confound the relationship between precarious work and health, leading to biased results. Secondly, only a few studies have directly addressed the role of gender in shaping the relationship. Moreover, available results on the gender differential are mixed and inconsistent: some found precarious employment being more detrimental for women's health, while others found no gender differences or stronger negative association for men. Finally, previous attempts to an empirical translation of the employment precariousness (EP) concept have not always been coherent with their theoretical framework. EP is usually assumed to be a multidimensional and continuous phenomenon; it is characterized by different dimensions of insecurity that may overlap in the same job and lead to different "degrees of precariousness." However, researchers have predominantly focused on one-dimensional indicators—e.g., temporary employment, subjective job insecurity—to measure EP and study the association with health. Besides the fact that this approach partially grasps the phenomenon's complexity, the major problem is the inconsistency of evidence that it has produced. Indeed, this line of inquiry generally reveals an ambiguous picture, with some studies finding substantial adverse effects of temporary over permanent employment, while others report only minor differences. To measure the (causal) effect of precarious work on self-rated health and its variation by gender, I focus on Germany and use four waves from SOEP data (2003, 2007, 2011, and 2015). Germany is a suitable context for my study. Indeed, since the 1980s, the labor market and welfare system have been restructured in many ways to increase the German economy's competitiveness in the global market. As a result, the (standard) employment relationship has been de-standardized: non-standard and atypical employment arrangements—i.e., part-time work, fixed-term contracts, mini-jobs, and work agencies—have increased over time while wages have lowered, even among workers with standard work. In addition, the power of unions has also fallen over the last three decades, leaving a large share of workers without collective protection. Because of this process of de-standardization, the link between wage employment and strong social rights has eroded, making workers more powerless and more vulnerable to labor market risks than in the past. EP refers to this uneven distribution of power in the employment relationship, which can be detrimental to workers' health. Indeed, by affecting individuals' access to power and other resources, EP puts precarious workers at risk of experiencing health shocks and influences their ability to gain and accumulate health advantages (Hp.1). Further, the focus on Germany allows me to investigate my second research question on the gender differential. Germany is usually regarded as a traditionalist gender regime: a context characterized by a configuration of roles. Here, being a caregiver is assumed to be women's primary role, whereas the primary breadwinner role is reserved for men. Although many signs of progress have been made over the last decades towards a greater equalization of opportunities and more egalitarianism, the breadwinner model has barely changed towards a modified version. Thus, women usually take on the double role of workers (the so-called secondary earner) and caregivers, and men still devote most of their time to paid work activities. Moreover, the overall upward trend towards more egalitarian gender ideologies has leveled off over the last decades, moving notably towards more traditional gender ideologies. In this setting, two alternative hypotheses are possible. Firstly, I assume that the negative relationship between EP and health is stronger for women than for men. This is because women are systematically more disadvantaged than men in the public and private spheres of life, having less access to formal and informal sources of power. These gender-related power asymmetries may interact with EP-related power asymmetries resulting in a stronger effect of EP on women's health than on men's health (Hp.2). An alternative way of looking at the gender differential is to consider the interaction that precariousness might have with men's and women's gender identities. According to this view, the negative relationship between EP and health is weaker for women than for men (Hp.2a). In a society with a gendered division of labor and a strong link between masculine identities and stable and well-rewarded job—i.e., a job that confers the role of primary family provider—a male worker with precarious employment might violate the traditional male gender role. Men in precarious jobs may perceive themselves (and by others) as possessing a socially undesirable characteristic, which conflicts with the stereotypical idea of themselves as the male breadwinner. Engaging in behaviors that contradict stereotypical gender identity may decrease self-esteem and foster feelings of inferiority, helplessness, and jealousy, leading to poor health. I develop a new indicator of EP that empirically translates a definition of EP as a multidimensional and continuous phenomenon. I assume that EP is a latent construct composed of seven dimensions of insecurity chosen according to the theory and previous empirical research: Income insecurity, social insecurity, legal insecurity, employment insecurity, working-time insecurity, representation insecurity, worker's vulnerability. The seven dimensions are proxied by eight indicators available in the four waves of the SOEP dataset. The EP composite indicator is obtained by performing a multiple correspondence analysis (MCA) on the eight indicators. This approach aims to construct a summary scale in which all dimensions contribute jointly to the measured experience of precariousness and its health impact. Further, the relationship between EP and 'general self-perceived health' is estimated by applying ordered probit random-effects estimators and calculating average marginal effect (further AME). Then, to control for unobserved heterogeneity, I implement correlated random-effects models that add to the model the within-individual means of the time-varying independent variables. To test the significance of the gender differential, I add an interaction term between EP and gender in the fully adjusted model in the pooled sample. My correlated random-effects models showed EP's negative and substantial 'effect' on self-perceived health for both men and women. Although nonsignificant, the evidence seems in line with previous cross-sectional literature. It supports the hypothesis that employment precariousness could be detrimental to workers' health. Further, my results showed the crucial role of unobserved heterogeneity in shaping the health consequences of precarious employment. This is particularly important as evidence accumulates, yet it is still mostly descriptive. Moreover, my results revealed a substantial difference among men and women in the relationship between EP and health: when EP increases, the risk of experiencing poor health increases much more for men than for women. This evidence falsifies previous theory according to whom the gender differential is contingent on the structurally disadvantaged position of women in western societies. In contrast, they seem to confirm the idea that men in precarious work could experience role conflict to a larger extent than women, as their self-standard is supposed to be the stereotypical breadwinner worker with a good and well-rewarded job. Finally, results from the multiple correspondence analysis contribute to the methodological debate on precariousness, showing that a multidimensional and continuous indicator can express a latent variable of EP. All in all, complementarities are revealed in the results of unemployment and employment precariousness, which have two implications: Policy-makers need to be aware that the total costs of unemployment and precariousness go far beyond the economic and material realm penetrating other fundamental life domains such as individual health. Moreover, they need to balance the trade-off between protecting adequately unemployed people and fostering high-quality employment in reaction to the highlighted market pressures. In this sense, the further development of a (universalistic) welfare state certainly helps mitigate the adverse health effects of unemployment and, therefore, the future costs of both individuals' health and welfare spending. In addition, the presence of a working partner is crucial for reducing the health consequences of employment instability. Therefore, policies aiming to increase female labor market participation should be promoted, especially in those contexts where the welfare state is less developed. Moreover, my results support the significance of taking account of a gender perspective in health research. The findings of the three articles show that job loss, unemployment, and precarious employment, in general, have adverse effects on men's health but less or absent consequences for women's health. Indeed, this suggests the importance of labor and health policies that consider and further distinguish the specific needs of the male and female labor force in Europe. Nevertheless, a further implication emerges: the health consequences of employment instability and de-standardization need to be investigated in light of the gender arrangements and the transforming gender relationships in specific cultural and institutional contexts. My results indeed seem to suggest that women's health advantage may be a transitory phenomenon, contingent on the predominant gendered institutional and cultural context. As the structural difference between men's and women's position in society is eroded, egalitarianism becomes the dominant normative status, so will probably be the gender difference in the health consequences of job loss and precariousness. Therefore, while gender equality in opportunities and roles is a desirable aspect for contemporary societies and a political goal that cannot be postponed further, this thesis raises a further and maybe more crucial question: What kind of equality should be pursued to provide men and women with both good life quality and equal chances in the public and private spheres? In this sense, I believe that social and labor policies aiming to reduce gender inequality in society should focus on improving women's integration into the labor market, implementing policies targeting men, and facilitating their involvement in the private sphere of life. Equal redistribution of social roles could activate a crucial transformation of gender roles and the cultural models that sustain and still legitimate gender inequality in Western societies.}, language = {en} } @article{ReeveNicholsonAltafetal.2022, author = {Reeve, Holly A. and Nicholson, Jake and Altaf, Farieha and Lonsdale, Thomas H. and Preissler, Janina and Lauterbach, Lars and Lenz, Oliver and Leimk{\"u}hler, Silke and Hollmann, Frank and Paul, Caroline E. and Vincent, Kylie A.}, title = {A hydrogen-driven biocatalytic approach to recycling synthetic analogues of NAD(P)H}, series = {Chemical communications : ChemComm}, volume = {58}, journal = {Chemical communications : ChemComm}, number = {75}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, issn = {1359-7345}, doi = {10.1039/d2cc02411j}, pages = {10540 -- 10543}, year = {2022}, abstract = {We demonstrate a recycling system for synthetic nicotinamide cofactor analogues using a soluble hydrogenase with turnover number of >1000 for reduction of the cofactor analogues by H-2. Coupling this system to an ene reductase, we show quantitative conversion of N-ethylmaleimide to N-ethylsuccinimide. The biocatalyst system retained >50\% activity after 7 h.}, language = {en} } @article{StoltnowLuedersGraafetal.2022, author = {Stoltnow, Malte and L{\"u}ders, Volker and Graaf, Stefan de and Niedermann, Samuel}, title = {A geochemical study of the Sweet Home mine, Colorado Mineral Belt, USA}, series = {Mineralium deposita : international journal for geology, mineralogy and geochemistry of mineral deposits}, volume = {57}, journal = {Mineralium deposita : international journal for geology, mineralogy and geochemistry of mineral deposits}, number = {5}, publisher = {Springer}, address = {Berlin ; Heidelberg}, issn = {0026-4598}, doi = {10.1007/s00126-022-01102-6}, pages = {801 -- 825}, year = {2022}, abstract = {Deep hydrothermal Mo, W, and base metal mineralization at the Sweet Home mine (Detroit City portal) formed in response to magmatic activity during the Oligocene. Microthermometric data of fluid inclusions trapped in greisen quartz and fluorite suggest that the early-stage mineralization at the Sweet Home mine precipitated from low- to medium-salinity (1.5-11.5 wt\% equiv. NaCl), CO2-bearing fluids at temperatures between 360 and 415 degrees C and at depths of at least 3.5 km. Stable isotope and noble gas isotope data indicate that greisen formation and base metal mineralization at the Sweet Home mine was related to fluids of different origins. Early magmatic fluids were the principal source for mantle-derived volatiles (CO2, H2S/SO2, noble gases), which subsequently mixed with significant amounts of heated meteoric water. Mixing of magmatic fluids with meteoric water is constrained by delta H-2(w)-delta O-18(w) relationships of fluid inclusions. The deep hydrothermal mineralization at the Sweet Home mine shows features similar to deep hydrothermal vein mineralization at Climax-type Mo deposits or on their periphery. This suggests that fluid migration and the deposition of ore and gangue minerals in the Sweet Home mine was triggered by a deep-seated magmatic intrusion. The findings of this study are in good agreement with the results of previous fluid inclusion studies of the mineralization of the Sweet Home mine and from Climax-type Mo porphyry deposits in the Colorado Mineral Belt.}, language = {en} } @article{IhdePufahlVoelkeretal.2022, author = {Ihde, Sven and Pufahl, Luise and V{\"o}lker, Maximilian and Goel, Asvin and Weske, Mathias}, title = {A framework for modeling and executing task}, series = {Computing : archives for informatics and numerical computation}, volume = {104}, journal = {Computing : archives for informatics and numerical computation}, publisher = {Springer}, address = {Wien}, issn = {0010-485X}, doi = {10.1007/s00607-022-01093-2}, pages = {2405 -- 2429}, year = {2022}, abstract = {As resources are valuable assets, organizations have to decide which resources to allocate to business process tasks in a way that the process is executed not only effectively but also efficiently. Traditional role-based resource allocation leads to effective process executions, since each task is performed by a resource that has the required skills and competencies to do so. However, the resulting allocations are typically not as efficient as they could be, since optimization techniques have yet to find their way in traditional business process management scenarios. On the other hand, operations research provides a rich set of analytical methods for supporting problem-specific decisions on resource allocation. This paper provides a novel framework for creating transparency on existing tasks and resources, supporting individualized allocations for each activity in a process, and the possibility to integrate problem-specific analytical methods of the operations research domain. To validate the framework, the paper reports on the design and prototypical implementation of a software architecture, which extends a traditional process engine with a dedicated resource management component. This component allows us to define specific resource allocation problems at design time, and it also facilitates optimized resource allocation at run time. The framework is evaluated using a real-world parcel delivery process. The evaluation shows that the quality of the allocation results increase significantly with a technique from operations research in contrast to the traditional applied rule-based approach.}, language = {en} } @article{LangenhanJaegerBaumetal.2022, author = {Langenhan, Jennifer and Jaeger, Carsten and Baum, Katharina and Simon, Mareike and Lisec, Jan}, title = {A flexible tool to correct superimposed mass isotopologue distributions in GC-APCI-MS flux experiments}, series = {Metabolites}, volume = {12}, journal = {Metabolites}, number = {5}, publisher = {MDPI}, address = {Basel}, issn = {2218-1989}, doi = {10.3390/metabo12050408}, pages = {10}, year = {2022}, abstract = {The investigation of metabolic fluxes and metabolite distributions within cells by means of tracer molecules is a valuable tool to unravel the complexity of biological systems. Technological advances in mass spectrometry (MS) technology such as atmospheric pressure chemical ionization (APCI) coupled with high resolution (HR), not only allows for highly sensitive analyses but also broadens the usefulness of tracer-based experiments, as interesting signals can be annotated de novo when not yet present in a compound library. However, several effects in the APCI ion source, i.e., fragmentation and rearrangement, lead to superimposed mass isotopologue distributions (MID) within the mass spectra, which need to be corrected during data evaluation as they will impair enrichment calculation otherwise. Here, we present and evaluate a novel software tool to automatically perform such corrections. We discuss the different effects, explain the implemented algorithm, and show its application on several experimental datasets. This adjustable tool is available as an R package from CRAN.}, language = {en} } @article{HaslVoelkleKretschmannetal.2022, author = {Hasl, Andrea and Voelkle, Manuel and Kretschmann, Julia and Richter, Dirk and Brunner, Martin}, title = {A dynamic structural equation approach to modeling wage dynamics and cumulative advantage across the lifespan}, series = {Multivariate Behavioral Research}, volume = {58}, journal = {Multivariate Behavioral Research}, number = {3}, publisher = {Routledge, Taylor \& Francis Group}, address = {Abingdon}, issn = {0027-3171}, doi = {10.1080/00273171.2022.2029339}, pages = {504 -- 525}, year = {2022}, abstract = {Wages and wage dynamics directly affect individuals' and families' daily lives. In this article, we show how major theoretical branches of research on wages and inequality-that is, cumulative advantage (CA), human capital theory, and the lifespan perspective-can be integrated into a coherent statistical framework and analyzed with multilevel dynamic structural equation modeling (DSEM). This opens up a new way to empirically investigate the mechanisms that drive growing inequality over time. We demonstrate the new approach by making use of longitudinal, representative U.S. data (NLSY-79). Analyses revealed fundamental between-person differences in both initial wages and autoregressive wage growth rates across the lifespan. Only 0.5\% of the sample experienced a "strict" CA and unbounded wage growth, whereas most individuals revealed logarithmic wage growth over time. Adolescent intelligence and adult educational levels explained substantial heterogeneity in both parameters. We discuss how DSEM may help researchers study CA processes and related developmental dynamics, and we highlight the extensions and limitations of the DSEM framework.}, language = {en} } @article{ReifarthBekirBapolisietal.2022, author = {Reifarth, Martin and Bekir, Marek and Bapolisi, Alain M. and Titov, Evgenii and Nusshardt, Fabian and Nowaczyk, Julius and Grigoriev, Dmitry and Sharma, Anjali and Saalfrank, Peter and Santer, Svetlana and Hartlieb, Matthias and B{\"o}ker, Alexander}, title = {A dual pH- and light-responsive spiropyrane-based surfactant}, series = {Angewandte Chemie : a journal of the Gesellschaft Deutscher Chemiker ; International edition}, volume = {61}, journal = {Angewandte Chemie : a journal of the Gesellschaft Deutscher Chemiker ; International edition}, number = {21}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1433-7851}, doi = {10.1002/anie.202114687}, pages = {10}, year = {2022}, abstract = {A cationic surfactant containing a spiropyrane unit is prepared exhibiting a dual-responsive adjustability of its surface-active characteristics. The switching mechanism of the system relies on the reversible conversion of the non-ionic spiropyrane (SP) to a zwitterionic merocyanine (MC) and can be controlled by adjusting the pH value and via light, resulting in a pH-dependent photoactivity: While the compound possesses a pronounced difference in surface activity between both forms under acidic conditions, this behavior is suppressed at a neutral pH level. The underlying switching processes are investigated in detail, and a thermodynamic explanation based on a combination of theoretical and experimental results is provided. This complex stimuli-responsive behavior enables remote-control of colloidal systems. To demonstrate its applicability, the surfactant is utilized for the pH-dependent manipulation of oil-in-water emulsions.}, language = {en} } @article{Schenck2022, author = {Schenck, Marcia C.}, title = {A different class of refugee: university scholarships and developmentalism in late 1960s Africa}, series = {Africa Today}, volume = {69}, journal = {Africa Today}, number = {1-2}, editor = {Schenck, Marcia C. and Njung, George N.}, publisher = {Indiana Univ. Press}, address = {Bloomington}, issn = {1527-1978}, doi = {10.2979/africatoday.69.1_2.07}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-569066}, pages = {134 -- 161}, year = {2022}, abstract = {Using documents assembled in connection with the 1967 Conference on the Legal, Economic and Social Aspects of African Refugee Problems, this article discusses African refugee higher-education discourses in the 1960s at the level of international organizations, volunteer agencies, and government representatives. Education and development history have recently been studied together, but this article focuses on the history of refugee higher education, which, it argues, needs to be understood within the development framework of human-capital theory, meant to support political pan African concerns for a decolonized continent and merged with humanitarian arguments to create a hybrid form of humanitarian developmentalism. The article zooms in on higher-education scholarships, above all for refugees from Southern Africa, as a means of support for human-capital development. It shows that refugee higher education was both a result and a driver of increased international exchanges, as evidenced at the 1967 conference.}, language = {en} } @article{AndjelkovicSimevskiChenetal.2022, author = {Andjelkovic, Marko and Simevski, Aleksandar and Chen, Junchao and Schrape, Oliver and Stamenkovic, Zoran and Krstić, Miloš and Ilic, Stefan and Ristic, Goran and Jaksic, Aleksandar and Vasovic, Nikola and Duane, Russell and Palma, Alberto J. and Lallena, Antonio M. and Carvajal, Miguel A.}, title = {A design concept for radiation hardened RADFET readout system for space applications}, series = {Microprocessors and microsystems}, volume = {90}, journal = {Microprocessors and microsystems}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0141-9331}, doi = {10.1016/j.micpro.2022.104486}, pages = {18}, year = {2022}, abstract = {Instruments for measuring the absorbed dose and dose rate under radiation exposure, known as radiation dosimeters, are indispensable in space missions. They are composed of radiation sensors that generate current or voltage response when exposed to ionizing radiation, and processing electronics for computing the absorbed dose and dose rate. Among a wide range of existing radiation sensors, the Radiation Sensitive Field Effect Transistors (RADFETs) have unique advantages for absorbed dose measurement, and a proven record of successful exploitation in space missions. It has been shown that the RADFETs may be also used for the dose rate monitoring. In that regard, we propose a unique design concept that supports the simultaneous operation of a single RADFET as absorbed dose and dose rate monitor. This enables to reduce the cost of implementation, since the need for other types of radiation sensors can be minimized or eliminated. For processing the RADFET's response we propose a readout system composed of analog signal conditioner (ASC) and a self-adaptive multiprocessing system-on-chip (MPSoC). The soft error rate of MPSoC is monitored in real time with embedded sensors, allowing the autonomous switching between three operating modes (high-performance, de-stress and fault-tolerant), according to the application requirements and radiation conditions.}, language = {en} } @phdthesis{Mertzen2022, author = {Mertzen, Daniela}, title = {A cross-linguistic investigation of similarity-based interference in sentence comprehension}, doi = {10.25932/publishup-55668}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-556685}, school = {Universit{\"a}t Potsdam}, pages = {xvii, 129}, year = {2022}, abstract = {The aim of this dissertation was to conduct a larger-scale cross-linguistic empirical investigation of similarity-based interference effects in sentence comprehension. Interference studies can offer valuable insights into the mechanisms that are involved in long-distance dependency completion. Many studies have investigated similarity-based interference effects, showing that syntactic and semantic information are employed during long-distance dependency formation (e.g., Arnett \& Wagers, 2017; Cunnings \& Sturt, 2018; Van Dyke, 2007, Van Dyke \& Lewis, 2003; Van Dyke \& McElree, 2011). Nevertheless, there are some important open questions in the interference literature that are critical to our understanding of the constraints involved in dependency resolution. The first research question concerns the relative timing of syntactic and semantic interference in online sentence comprehension. Only few interference studies have investigated this question, and, to date, there is not enough data to draw conclusions with regard to their time course (Van Dyke, 2007; Van Dyke \& McElree, 2011). Our first cross-linguistic study explores the relative timing of syntactic and semantic interference in two eye-tracking reading experiments that implement the study design used in Van Dyke (2007). The first experiment tests English sentences. The second, larger-sample experiment investigates the two interference types in German. Overall, the data suggest that syntactic and semantic interference can arise simultaneously during retrieval. The second research question concerns a special case of semantic interference: We investigate whether cue-based retrieval interference can be caused by semantically similar items which are not embedded in a syntactic structure. This second interference study builds on a landmark study by Van Dyke \& McElree (2006). The study design used in their study is unique in that it is able to pin down the source of interference as a consequence of cue overload during retrieval, when semantic retrieval cues do not uniquely match the retrieval target. Unlike most other interference studies, this design is able to rule out encoding interference as an alternative explanation. Encoding accounts postulate that it is not cue overload at the retrieval site but the erroneous encoding of similar linguistic items in memory that leads to interference (Lewandowsky et al., 2008; Oberauer \& Kliegl, 2006). While Van Dyke \& McElree (2006) reported cue-based retrieval interference from sentence-external distractors, the evidence for this effect was weak. A subsequent study did not show interference of this type (Van Dyke et al., 2014). Given these inconclusive findings, further research is necessary to investigate semantic cue-based retrieval interference. The second study in this dissertation provides a larger-scale cross-linguistic investigation of cue-based retrieval interference from sentence-external items. Three larger-sample eye-tracking studies in English, German, and Russian tested cue-based interference in the online processing of filler-gap dependencies. This study further extends the previous research by investigating interference in each language under varying task demands (Logačev \& Vasishth, 2016; Swets et al., 2008). Overall, we see some very modest support for proactive cue-based retrieval interference in English. Unexpectedly, this was observed only under a low task demand. In German and Russian, there is some evidence against the interference effect. It is possible that interference is attenuated in languages with richer case marking. In sum, the cross-linguistic experiments on the time course of syntactic and semantic interference from sentence-internal distractors support existing evidence of syntactic and semantic interference during sentence comprehension. Our data further show that both types of interference effects can arise simultaneously. Our cross-linguistic experiments investigating semantic cue-based retrieval interference from sentence-external distractors suggest that this type of interference may arise only in specific linguistic contexts.}, language = {en} } @article{Buerger2022, author = {B{\"u}rger, Gerd}, title = {A conundrum of trends}, series = {Journal of hydrology}, volume = {609}, journal = {Journal of hydrology}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0022-1694}, doi = {10.1016/j.jhydrol.2022.127745}, pages = {3}, year = {2022}, abstract = {This comment is meant to reiterate two warnings: One applies to the uncritical use of ready-made (openly available) program packages, and one to the estimation of trends in serially correlated time series. Both warnings apply to the recent publication of Lischeid et al. about lake-level trends in Germany.}, language = {en} } @article{MaierWiljesHartungetal.2022, author = {Maier, Corinna Sabrina and Wiljes, Jana de and Hartung, Niklas and Kloft, Charlotte and Huisinga, Wilhelm}, title = {A continued learning approach for model-informed precision dosing}, series = {CPT: pharmacometrics \& systems pharmacology}, volume = {11}, journal = {CPT: pharmacometrics \& systems pharmacology}, number = {2}, publisher = {London}, address = {Nature Publ. Group}, issn = {2163-8306}, doi = {10.1002/psp4.12745}, pages = {185 -- 198}, year = {2022}, abstract = {Model-informed precision dosing (MIPD) is a quantitative dosing framework that combines prior knowledge on the drug-disease-patient system with patient data from therapeutic drug/ biomarker monitoring (TDM) to support individualized dosing in ongoing treatment. Structural models and prior parameter distributions used in MIPD approaches typically build on prior clinical trials that involve only a limited number of patients selected according to some exclusion/inclusion criteria. Compared to the prior clinical trial population, the patient population in clinical practice can be expected to also include altered behavior and/or increased interindividual variability, the extent of which, however, is typically unknown. Here, we address the question of how to adapt and refine models on the level of the model parameters to better reflect this real-world diversity. We propose an approach for continued learning across patients during MIPD using a sequential hierarchical Bayesian framework. The approach builds on two stages to separate the update of the individual patient parameters from updating the population parameters. Consequently, it enables continued learning across hospitals or study centers, because only summary patient data (on the level of model parameters) need to be shared, but no individual TDM data. We illustrate this continued learning approach with neutrophil-guided dosing of paclitaxel. The present study constitutes an important step toward building confidence in MIPD and eventually establishing MIPD increasingly in everyday therapeutic use.}, language = {en} } @article{StaufferMengeshaSeifertetal.2022, author = {Stauffer, Maxime and Mengesha, Isaak and Seifert, Konrad and Krawczuk, Igor and Fischer, Jens and Serugendo, Giovanna Di Marzo}, title = {A computational turn in policy process studies}, series = {Complexity}, volume = {2022}, journal = {Complexity}, publisher = {Wiley-Hindawi}, address = {London}, issn = {1076-2787}, doi = {10.1155/2022/8210732}, pages = {17}, year = {2022}, abstract = {The past three decades of policy process studies have seen the emergence of a clear intellectual lineage with regard to complexity. Implicitly or explicitly, scholars have employed complexity theory to examine the intricate dynamics of collective action in political contexts. However, the methodological counterparts to complexity theory, such as computational methods, are rarely used and, even if they are, they are often detached from established policy process theory. Building on a critical review of the application of complexity theory to policy process studies, we present and implement a baseline model of policy processes using the logic of coevolving networks. Our model suggests that an actor's influence depends on their environment and on exogenous events facilitating dialogue and consensus-building. Our results validate previous opinion dynamics models and generate novel patterns. Our discussion provides ground for further research and outlines the path for the field to achieve a computational turn.}, language = {en} } @article{ArboledaZapataGuillemoteauTronicke2022, author = {Arboleda-Zapata, Mauricio and Guillemoteau, Julien and Tronicke, Jens}, title = {A comprehensive workflow to analyze ensembles of globally inverted 2D electrical resistivity models}, series = {Journal of applied geophysics}, volume = {196}, journal = {Journal of applied geophysics}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0926-9851}, doi = {10.1016/j.jappgeo.2021.104512}, pages = {12}, year = {2022}, abstract = {Electrical resistivity tomography (ERT) aims at imaging the subsurface resistivity distribution and provides valuable information for different geological, engineering, and hydrological applications. To obtain a subsurface resistivity model from measured apparent resistivities, stochastic or deterministic inversion procedures may be employed. Typically, the inversion of ERT data results in non-unique solutions; i.e., an ensemble of different models explains the measured data equally well. In this study, we perform inference analysis of model ensembles generated using a well-established global inversion approach to assess uncertainties related to the nonuniqueness of the inverse problem. Our interpretation strategy starts by establishing model selection criteria based on different statistical descriptors calculated from the data residuals. Then, we perform cluster analysis considering the inverted resistivity models and the corresponding data residuals. Finally, we evaluate model uncertainties and residual distributions for each cluster. To illustrate the potential of our approach, we use a particle swarm optimization (PSO) algorithm to obtain an ensemble of 2D layer-based resistivity models from a synthetic data example and a field data set collected in Loon-Plage, France. Our strategy performs well for both synthetic and field data and allows us to extract different plausible model scenarios with their associated uncertainties and data residual distributions. Although we demonstrate our workflow using 2D ERT data and a PSObased inversion approach, the proposed strategy is general and can be adapted to analyze model ensembles generated from other kinds of geophysical data and using different global inversion approaches.}, language = {en} } @article{AgarwalGuntuBanerjeeetal.2022, author = {Agarwal, Ankit and Guntu, Ravikumar and Banerjee, Abhirup and Gadhawe, Mayuri Ashokrao and Marwan, Norbert}, title = {A complex network approach to study the extreme precipitation patterns in a river basin}, series = {Chaos : an interdisciplinary journal of nonlinear science}, volume = {32}, journal = {Chaos : an interdisciplinary journal of nonlinear science}, number = {1}, publisher = {American Institute of Physics}, address = {Woodbury, NY}, issn = {1054-1500}, doi = {10.1063/5.0072520}, pages = {12}, year = {2022}, abstract = {The quantification of spatial propagation of extreme precipitation events is vital in water resources planning and disaster mitigation. However, quantifying these extreme events has always been challenging as many traditional methods are insufficient to capture the nonlinear interrelationships between extreme event time series. Therefore, it is crucial to develop suitable methods for analyzing the dynamics of extreme events over a river basin with a diverse climate and complicated topography. Over the last decade, complex network analysis emerged as a powerful tool to study the intricate spatiotemporal relationship between many variables in a compact way. In this study, we employ two nonlinear concepts of event synchronization and edit distance to investigate the extreme precipitation pattern in the Ganga river basin. We use the network degree to understand the spatial synchronization pattern of extreme rainfall and identify essential sites in the river basin with respect to potential prediction skills. The study also attempts to quantify the influence of precipitation seasonality and topography on extreme events. The findings of the study reveal that (1) the network degree is decreased in the southwest to northwest direction, (2) the timing of 50th percentile precipitation within a year influences the spatial distribution of degree, (3) the timing is inversely related to elevation, and (4) the lower elevation greatly influences connectivity of the sites. The study highlights that edit distance could be a promising alternative to analyze event-like data by incorporating event time and amplitude and constructing complex networks of climate extremes.}, language = {en} } @article{ZoccaratoSherMikietal.2022, author = {Zoccarato, Luca and Sher, Daniel and Miki, Takeshi and Segre, Daniel and Grossart, Hans-Peter}, title = {A comparative whole-genome approach identifies bacterial traits for marine microbial interactions}, series = {Communications biology}, volume = {5}, journal = {Communications biology}, number = {1}, publisher = {Springer Nature}, address = {Berlin}, issn = {2399-3642}, doi = {10.1038/s42003-022-03184-4}, pages = {13}, year = {2022}, abstract = {Luca Zoccarato, Daniel Sher et al. leverage publicly available bacterial genomes from marine and other environments to examine traits underlying microbial interactions. Their results provide a valuable resource to investigate clusters of functional and linked traits to better understand marine bacteria community assembly and dynamics. Microbial interactions shape the structure and function of microbial communities with profound consequences for biogeochemical cycles and ecosystem health. Yet, most interaction mechanisms are studied only in model systems and their prevalence is unknown. To systematically explore the functional and interaction potential of sequenced marine bacteria, we developed a trait-based approach, and applied it to 473 complete genomes (248 genera), representing a substantial fraction of marine microbial communities. We identified genome functional clusters (GFCs) which group bacterial taxa with common ecology and life history. Most GFCs revealed unique combinations of interaction traits, including the production of siderophores (10\% of genomes), phytohormones (3-8\%) and different B vitamins (57-70\%). Specific GFCs, comprising Alpha- and Gammaproteobacteria, displayed more interaction traits than expected by chance, and are thus predicted to preferentially interact synergistically and/or antagonistically with bacteria and phytoplankton. Linked trait clusters (LTCs) identify traits that may have evolved to act together (e.g., secretion systems, nitrogen metabolism regulation and B vitamin transporters), providing testable hypotheses for complex mechanisms of microbial interactions. Our approach translates multidimensional genomic information into an atlas of marine bacteria and their putative functions, relevant for understanding the fundamental rules that govern community assembly and dynamics.}, language = {en} } @article{MbebiBreitlerBordeauxetal.2022, author = {Mbebi, Alain J. and Breitler, Jean-Christophe and Bordeaux, M'elanie and Sulpice, Ronan and McHale, Marcus and Tong, Hao and Toniutti, Lucile and Castillo, Jonny Alonso and Bertrand, Benoit and Nikoloski, Zoran}, title = {A comparative analysis of genomic and phenomic predictions of growth-related traits in 3-way coffee hybrids}, series = {G3: Genes, genomes, genetics}, volume = {12}, journal = {G3: Genes, genomes, genetics}, number = {9}, publisher = {Genetics Soc. of America}, address = {Pittsburgh, PA}, issn = {2160-1836}, doi = {10.1093/g3journal/jkac170}, pages = {11}, year = {2022}, abstract = {Genomic prediction has revolutionized crop breeding despite remaining issues of transferability of models to unseen environmental conditions and environments. Usage of endophenotypes rather than genomic markers leads to the possibility of building phenomic prediction models that can account, in part, for this challenge. Here, we compare and contrast genomic prediction and phenomic prediction models for 3 growth-related traits, namely, leaf count, tree height, and trunk diameter, from 2 coffee 3-way hybrid populations exposed to a series of treatment-inducing environmental conditions. The models are based on 7 different statistical methods built with genomic markers and ChlF data used as predictors. This comparative analysis demonstrates that the best-performing phenomic prediction models show higher predictability than the best genomic prediction models for the considered traits and environments in the vast majority of comparisons within 3-way hybrid populations. In addition, we show that phenomic prediction models are transferrable between conditions but to a lower extent between populations and we conclude that chlorophyll a fluorescence data can serve as alternative predictors in statistical models of coffee hybrid performance. Future directions will explore their combination with other endophenotypes to further improve the prediction of growth-related traits for crops.}, language = {en} } @article{CabukUenlue2022, author = {{\c{C}}abuk, Uğur and {\"U}nl{\"u}, Ercan Sel{\c{c}}uk}, title = {A combined de novo assembly approach increases the quality of prokaryotic draft genomes}, series = {Folia microbiologica : international journal for general, environmental and applied microbiology, and immunology}, volume = {67}, journal = {Folia microbiologica : international journal for general, environmental and applied microbiology, and immunology}, publisher = {Springer}, address = {Dordrecht}, issn = {0015-5632}, doi = {10.1007/s12223-022-00980-7}, pages = {801 -- 810}, year = {2022}, abstract = {Next-generation sequencing methods provide comprehensive data for the analysis of structural and functional analysis of the genome. The draft genomes with low contig number and high N50 value can give insight into the structure of the genome as well as provide information on the annotation of the genome. In this study, we designed a pipeline that can be used to assemble prokaryotic draft genomes with low number of contigs and high N50 value. We aimed to use combination of two de novo assembly tools (SPAdes and IDBA-Hybrid) and evaluate the impact of this approach on the quality metrics of the assemblies. The followed pipeline was tested with the raw sequence data with short reads (< 300) for a total of 10 species from four different genera. To obtain the final draft genomes, we firstly assembled the sequences using SPAdes to find closely related organism using the extracted 16 s rRNA from it. IDBA-Hybrid assembler was used to obtain the second assembly data using the closely related organism genome. SPAdes assembler tool was implemented using the second assembly, produced by IDBA-hybrid as a hint. The results were evaluated using QUAST and BUSCO. The pipeline was successful for the reduction of the contig numbers and increasing the N50 statistical values in the draft genome assemblies while preserving the coverage of the draft genomes.}, language = {en} } @article{KrebsRakotoarinoroStechetal.2022, author = {Krebs, Simon K. and Rakotoarinoro, Nathanael and Stech, Marlitt and Zemella, Anne and Kubick, Stefan}, title = {A CHO-based cell-free dual fluorescence reporter system for the straightforward assessment of amber suppression and scFv functionality}, series = {Frontiers in Bioengineering and Biotechnology}, volume = {10}, journal = {Frontiers in Bioengineering and Biotechnology}, publisher = {Frontiers Media}, address = {Lausanne}, issn = {2296-4185}, doi = {10.3389/fbioe.2022.873906}, pages = {15}, year = {2022}, abstract = {Incorporation of noncanonical amino acids (ncAAs) with bioorthogonal reactive groups by amber suppression allows the generation of synthetic proteins with desired novel properties. Such modified molecules are in high demand for basic research and therapeutic applications such as cancer treatment and in vivo imaging. The positioning of the ncAA-responsive codon within the protein's coding sequence is critical in order to maintain protein function, achieve high yields of ncAA-containing protein, and allow effective conjugation. Cell-free ncAA incorporation is of particular interest due to the open nature of cell-free systems and their concurrent ease of manipulation. In this study, we report a straightforward workflow to inquire ncAA positions in regard to incorporation efficiency and protein functionality in a Chinese hamster ovary (CHO) cell-free system. As a model, the well-established orthogonal translation components Escherichia coli tyrosyl-tRNA synthetase (TyrRS) and tRNATyr(CUA) were used to site-specifically incorporate the ncAA p-azido-l-phenylalanine (AzF) in response to UAG codons. A total of seven ncAA sites within an anti-epidermal growth factor receptor (EGFR) single-chain variable fragment (scFv) N-terminally fused to the red fluorescent protein mRFP1 and C-terminally fused to the green fluorescent protein sfGFP were investigated for ncAA incorporation efficiency and impact on antigen binding. The characterized cell-free dual fluorescence reporter system allows screening for ncAA incorporation sites with high incorporation efficiency that maintain protein activity. It is parallelizable, scalable, and easy to operate. We propose that the established CHO-based cell-free dual fluorescence reporter system can be of particular interest for the development of antibody-drug conjugates (ADCs).}, language = {en} } @article{HaueisStechKubick2022, author = {Haueis, Lisa and Stech, Marlitt and Kubick, Stefan}, title = {A Cell-free Expression Pipeline for the Generation and Functional Characterization of Nanobodies}, series = {Frontiers in Bioengineering and Biotechnology}, volume = {10}, journal = {Frontiers in Bioengineering and Biotechnology}, publisher = {Frontiers Media}, address = {Lausanne}, issn = {2296-4185}, doi = {10.3389/fbioe.2022.896763}, pages = {11}, year = {2022}, abstract = {Cell-free systems are well-established platforms for the rapid synthesis, screening, engineering and modification of all kinds of recombinant proteins ranging from membrane proteins to soluble proteins, enzymes and even toxins. Also within the antibody field the cell-free technology has gained considerable attention with respect to the clinical research pipeline including antibody discovery and production. Besides the classical full-length monoclonal antibodies (mAbs), so-called "nanobodies" (Nbs) have come into focus. A Nb is the smallest naturally-derived functional antibody fragment known and represents the variable domain (VHH, similar to 15 kDa) of a camelid heavy-chain-only antibody (HCAb). Based on their nanoscale and their special structure, Nbs display striking advantages concerning their production, but also their characteristics as binders, such as high stability, diversity, improved tissue penetration and reaching of cavity-like epitopes. The classical way to produce Nbs depends on the use of living cells as production host. Though cell-based production is well-established, it is still time-consuming, laborious and hardly amenable for high-throughput applications. Here, we present for the first time to our knowledge the synthesis of functional Nbs in a standardized mammalian cell-free system based on Chinese hamster ovary (CHO) cell lysates. Cell-free reactions were shown to be time-efficient and easy-to-handle allowing for the "on demand" synthesis of Nbs. Taken together, we complement available methods and demonstrate a promising new system for Nb selection and validation.}, language = {en} } @article{BergMohnickeNendel2022, author = {Berg-Mohnicke, Michael and Nendel, Claas}, title = {A case for object capabilities as the foundation of a distributed environmental model and simulation infrastructure}, series = {Environmental modelling \& software with environment data news}, volume = {156}, journal = {Environmental modelling \& software with environment data news}, publisher = {Elsevier}, address = {Oxford}, issn = {1364-8152}, doi = {10.1016/j.envsoft.2022.105471}, pages = {12}, year = {2022}, abstract = {With the advent of increasingly powerful computational architectures, scientists use these possibilities to create simulations of ever-increasing size and complexity. Large-scale simulations of environmental systems require huge amounts of resources. Managing these in an operational way becomes increasingly complex and difficult to handle for individual scientists. State-of-the-art simulation infrastructures usually provide the necessary re-sources in a centralised setup, which often results in an all-or-nothing choice for the user. Here, we outline an alternative approach to handling this complexity, while rendering the use of high-performance hardware and large datasets still possible. It retains a number of desirable properties: (i) a decentralised structure, (ii) easy sharing of resources to promote collaboration and (iii) secure access to everything, including natural delegation of authority across levels and system boundaries. We show that the object capability paradigm will cover these issues, and present the first steps towards developing a simulation infrastructure based on these principles.}, language = {en} } @phdthesis{Hesse2022, author = {Hesse, G{\"u}nter}, title = {A benchmark for enterprise stream processing architectures}, doi = {10.25932/publishup-56600}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-566000}, school = {Universit{\"a}t Potsdam}, pages = {ix, 148}, year = {2022}, abstract = {Data stream processing systems (DSPSs) are a key enabler to integrate continuously generated data, such as sensor measurements, into enterprise applications. DSPSs allow to steadily analyze information from data streams, e.g., to monitor manufacturing processes and enable fast reactions to anomalous behavior. Moreover, DSPSs continuously filter, sample, and aggregate incoming streams of data, which reduces the data size, and thus data storage costs. The growing volumes of generated data have increased the demand for high-performance DSPSs, leading to a higher interest in these systems and to the development of new DSPSs. While having more DSPSs is favorable for users as it allows choosing the system that satisfies their requirements the most, it also introduces the challenge of identifying the most suitable DSPS regarding current needs as well as future demands. Having a solution to this challenge is important because replacements of DSPSs require the costly re-writing of applications if no abstraction layer is used for application development. However, quantifying performance differences between DSPSs is a difficult task. Existing benchmarks fail to integrate all core functionalities of DSPSs and lack tool support, which hinders objective result comparisons. Moreover, no current benchmark covers the combination of streaming data with existing structured business data, which is particularly relevant for companies. This thesis proposes a performance benchmark for enterprise stream processing called ESPBench. With enterprise stream processing, we refer to the combination of streaming and structured business data. Our benchmark design represents real-world scenarios and allows for an objective result comparison as well as scaling of data. The defined benchmark query set covers all core functionalities of DSPSs. The benchmark toolkit automates the entire benchmark process and provides important features, such as query result validation and a configurable data ingestion rate. To validate ESPBench and to ease the use of the benchmark, we propose an example implementation of the ESPBench queries leveraging the Apache Beam software development kit (SDK). The Apache Beam SDK is an abstraction layer designed for developing stream processing applications that is applied in academia as well as enterprise contexts. It allows to run the defined applications on any of the supported DSPSs. The performance impact of Apache Beam is studied in this dissertation as well. The results show that there is a significant influence that differs among DSPSs and stream processing applications. For validating ESPBench, we use the example implementation of the ESPBench queries developed using the Apache Beam SDK. We benchmark the implemented queries executed on three modern DSPSs: Apache Flink, Apache Spark Streaming, and Hazelcast Jet. The results of the study prove the functioning of ESPBench and its toolkit. ESPBench is capable of quantifying performance characteristics of DSPSs and of unveiling differences among systems. The benchmark proposed in this thesis covers all requirements to be applied in enterprise stream processing settings, and thus represents an improvement over the current state-of-the-art.}, language = {en} } @article{LeongRaffeinerSpintietal.2022, author = {Leong, Jia Xuan and Raffeiner, Margot and Spinti, Daniela and Langin, Gautier and Franz-Wachtel, Mirita and Guzman, Andrew R. and Kim, Jung-Gun and Pandey, Pooja and Minina, Alyona E. and Macek, Boris and Hafren, Anders and Bozkurt, Tolga O. and Mudgett, Mary Beth and B{\"o}rnke, Frederik and Hofius, Daniel and Uestuen, Suayib}, title = {A bacterial effector counteracts host autophagy by promoting degradation of an autophagy component}, series = {The EMBO journal}, volume = {41}, journal = {The EMBO journal}, number = {13}, publisher = {Wiley}, address = {Hoboken}, issn = {0261-4189}, doi = {10.15252/embj.2021110352}, pages = {17}, year = {2022}, abstract = {Beyond its role in cellular homeostasis, autophagy plays anti- and promicrobial roles in host-microbe interactions, both in animals and plants. One prominent role of antimicrobial autophagy is to degrade intracellular pathogens or microbial molecules, in a process termed xenophagy. Consequently, microbes evolved mechanisms to hijack or modulate autophagy to escape elimination. Although well-described in animals, the extent to which xenophagy contributes to plant-bacteria interactions remains unknown. Here, we provide evidence that Xanthomonas campestris pv. vesicatoria (Xcv) suppresses host autophagy by utilizing type-III effector XopL. XopL interacts with and degrades the autophagy component SH3P2 via its E3 ligase activity to promote infection. Intriguingly, XopL is targeted for degradation by defense-related selective autophagy mediated by NBR1/Joka2, revealing a complex antagonistic interplay between XopL and the host autophagy machinery. Our results implicate plant antimicrobial autophagy in the depletion of a bacterial virulence factor and unravel an unprecedented pathogen strategy to counteract defense-related autophagy in plant-bacteria interactions.}, language = {en} } @article{WeidleWiesenbergElSharkawyetal.2022, author = {Weidle, Christian and Wiesenberg, Lars and El-Sharkawy, Amr and Kr{\"u}ger, Frank and Scharf, Andreas and Agard, Philippe and Meier, Thomas}, title = {A 3-D crustal shear wave velocity model and Moho map below the Semail Ophiolite, eastern Arabia}, series = {Geophysical journal international}, volume = {231}, journal = {Geophysical journal international}, number = {2}, publisher = {Oxford University Press}, address = {Oxford}, issn = {0956-540X}, doi = {10.1093/gji/ggac223}, pages = {817 -- 834}, year = {2022}, abstract = {The Semail Ophiolite in eastern Arabia is the largest and best-exposed slice of oceanic lithosphere on land. Detailed knowledge of the tectonic evolution of the shallow crust, in particular during and after ophiolite obduction in Late Cretaceous times is contrasted by few constraints on physical and compositional properties of the middle and lower continental crust below the obducted units. The role of inherited, pre-obduction crustal architecture remains therefore unaccounted for in our understanding of crustal evolution and the present-day geology. Based on seismological data acquired during a 27-month campaign in northern Oman, Ambient Seismic Noise Tomography and Receiver Function analysis provide for the first time a 3-D radially anisotropic shear wave velocity (V-S) model and a consistent Moho map below the iconic Semail Ophiolite. The model highlights deep crustal boundaries that segment the eastern Arabian basement in two distinct units. The previously undescribed Western Jabal Akhdar Zone separates Arabian crust with typical continental properties and a thickness of similar to 40-45 km in the northwest from a compositionally different terrane in the southeast that is interpreted as a terrane accreted during the Pan-African orogeny in Neoproterozoic times. East of the Ibra Zone, another deep crustal boundary, crustal thickness decreases to 30-35 km and very high lower crustal V-S suggest large-scale mafic intrusions into, and possible underplating of the Arabian continental crust that occurred most likely during Permian breakup of Pangea. Mafic reworking is sharply bounded by the (upper crustal) Semail Gap Fault Zone, northwest of which no such high velocities are found in the crust. Topography of the Oman Mountains is supported by a mild crustal root and Moho depth below the highest topography, the Jabal Akhdar Dome, is similar to 42 km. Radial anisotropy is robustly resolved in the upper crust and aids in discriminating dipping allochthonous units from autochthonous sedimentary rocks that are indistinguishable by isotropic V-S alone. Lateral thickness variations of the ophiolite highlight the Haylayn Ophiolite Massif on the northern flank of Jabal Akhdar Dome and the Hawasina Window as the deepest reaching unit. Ophiolite thickness is similar to 10 km in the southern and northern massifs, and <= 5 km elsewhere.}, language = {en} } @article{SperlichKoeckerling2022, author = {Sperlich, Eric and K{\"o}ckerling, Martin}, title = {[Nb6Cl14(pyrazine)(4)], a versatile precursor for ligand-supported hexanuclear niobium cluster compounds: synthesis, characterization, follow-up reactions, and intermolecular interactions}, series = {Inorganic chemistry}, volume = {61}, journal = {Inorganic chemistry}, number = {5}, publisher = {American Chemical Society}, address = {Washington}, issn = {0020-1669}, doi = {10.1021/acs.inorgchem.1c03109}, pages = {2409 -- 2420}, year = {2022}, abstract = {The compound [Nb6Cl14(pyrazine)(4)]center dot 2CH(2)Cl(2) (1) was investigated for its suitability as a starting compound for new ligand-supported hexanuclear niobium cluster compounds. The synthesis, stability to air and increased temperature, solubility and usability for subsequent reactions of 1, and purification and separation of the reaction products are discussed. The compounds with cluster units [Nb6Cl14L4], where L = iso-quinoline N-oxides (2), 1,1-dimethylethylenediamines (3), or thiazoles (4), and [Nb6Cl14(PEt3)(3.76)(Et3PO)(0.24)]-[Nb6Cl14(MeCN)(4)]center dot 4MeCN (5) are presented as follow-up products. The crystal structures of compounds 1-5 are analyzed, and the structures are discussed with respect to their intraand intermolecular bonding situations and crystal packing. In addition to hydrogen bonds and pi-pi interactions, the appearance of chalcogen and halogen bonds and lone pair-pi interactions between Nb-6 cluster units was observed for the first time.}, language = {en} } @inproceedings{YaelLapidotTzuberi2022, author = {Yael, Attia and Lapidot, Elad and Tzuberi, Hannah}, title = {60 Years after the Algerian War}, publisher = {Katholische Akademie Berlin}, address = {Berlin}, year = {2022}, abstract = {Over the six decades since it officially ended, the Algerian War has become a key event for marking, retrospectively, the beginning of a new era in European, Western and global history. This new era is characterized by the proclaimed end of Western hegemony - by the proclaimed end of European history as global, universal history. This era, our era, understands itself as the time after the domination of the West, a time or multiple times of "post": the time of postcolonialism, but also postmodernity, postsecularism, posthumanism. The times of "post" are characterized by a fundamental reconfiguration of the relations between European civilization and its Others, first and foremost by the proclaimed split between Europe and its Others, and more generally by the disintegration, disruption and dispersion of the - allegedly - unified space of culture, knowledge and discourse. The postcolonial era is an era of diversity and difference, an era of dispersions and diasporas, where the space of culture is a space of multiple cultures, a space of in-between, of "inter": the space of the intercultural, but also the interreligious, interethnic, interracial and inter-epistemic. This conference will reflect on the "inter" in the time of "post". We invited scholars, thinkers, intellectuals and artists to discuss various aspects and models of intercultural dynamics that have been developed and articulated in the aftermath of the Algerian War or of other events that marked the decline of Western hegemony, such as the Second Vatican, May 1968 or the Vietnam War. How did the age of decolonization reshape the discourse and practice of intercultural relations? To what extent interculturality itself is a sign or a site of decolonization? To what extent, on the contrary, intercultural relations may reproduce colonial or generate neocolonial patterns? Contributions examine the emergence of intercultural notions and practices in various intellectual traditions, European or non-European; the development of new categories and constellations of identity, otherness and dialogue; the interrelations between epistemic, cultural, discursive, religious and political aspects; as well as reactions to these new developments and various forms of critique and resistance. We are especially interested in how this reflection may shed light on socio-political and cultural phenomena, trends and concerns of the present time.}, language = {en} } @article{Crome2022, author = {Crome, Erhard}, title = {50 jahre Grundlagenvertrag}, series = {WeltTrends : das außenpolitische Journal}, volume = {30}, journal = {WeltTrends : das außenpolitische Journal}, publisher = {WeltTrends}, address = {Potsdam}, isbn = {978-3-947802-91-3}, issn = {0944-8101}, pages = {56 -- 60}, year = {2022}, language = {de} } @article{MazurekBudzyńskaBehlNeumannetal.2022, author = {Mazurek-Budzyńska, Magdalena and Behl, Marc and Neumann, Richard and Lendlein, Andreas}, title = {4D-actuators by 3D-printing combined with water-based curing}, series = {Materials today. Communications}, volume = {30}, journal = {Materials today. Communications}, publisher = {Elsevier}, address = {Amsterdam}, issn = {2352-4928}, doi = {10.1016/j.mtcomm.2021.102966}, pages = {7}, year = {2022}, abstract = {The shape and the actuation capability of state of the art robotic devices typically relies on multimaterial systems from a combination of geometry determining materials and actuation components. Here, we present multifunctional 4D-actuators processable by 3D-printing, in which the actuator functionality is integrated into the shaped body. The materials are based on crosslinked poly(carbonate-urea-urethane) networks (PCUU), synthesized in an integrated process, applying reactive extrusion and subsequent water-based curing. Actuation capability could be added to the PCUU, prepared from aliphatic oligocarbonate diol, isophorone diisocyanate (IPDI) and water, in a thermomechanical programming process. When programmed with a strain of epsilon(prog) = 1400\% the PCUU networks exhibited actuation apparent by reversible elongation epsilon'(rev) of up to 22\%. In a gripper a reversible bending epsilon'(rev)((be)(nd)()) in the range of 37-60\% was achieved when the actuation temperature (T-high) was varied between 45 degrees C and 49 degrees C. The integration of actuation and shape formation could be impressively demonstrated in two PCUU-based reversible fastening systems, which were able to hold weights of up to 1.1 kg. In this way, the multifunctional materials are interesting candidate materials for robotic applications where a freedom in shape design and actuation is required as well as for sustainable fastening systems.}, language = {en} } @article{FranzSudoKhomenko2022, author = {Franz, Gerhard and Sudo, Masafumi and Khomenko, Vladimir}, title = {40Ar/39Ar dating of a hydrothermal pegmatitic buddingtonite-muscovite assemblage from Volyn, Ukraine}, series = {European journal of mineralogy : EJM : an international journal on mineralogy, petrology, geochemistry, and related sciences}, volume = {34}, journal = {European journal of mineralogy : EJM : an international journal on mineralogy, petrology, geochemistry, and related sciences}, number = {1}, publisher = {Copernicus}, address = {G{\"o}ttingen}, issn = {0935-1221}, doi = {10.5194/ejm-34-7-2022}, pages = {7 -- 18}, year = {2022}, abstract = {We determined Ar-40/Ar-39 ages of buddingtonite, occurring together with muscovite, with the laser-ablation method. This is the first attempt to date the NH4-feldspar buddingtonite, which is typical for sedimentary-diagenetic environments of sediments, rich in organic matter, or in hydrothermal environments, associated with volcanic geyser systems. The sample is a hydrothermal breccia, coming from the Paleoproterozoic pegmatite field of the Korosten Plutonic Complex, Volyn, Ukraine. A detailed characterization by optical methods, electron microprobe analyses, backscattered electron imaging, and IR analyses showed that the buddingtonite consists of euhedral-appearing platy crystals of tens of micrometers wide, 100 or more micrometers in length, which consist of fine-grained fibers of <= 1 mu m thickness. The crystals are sector and growth zoned in terms of K-NH4-H3O content. The content of K allows for an age determination with the Ar-40/Ar-39 method, as well as in the accompanying muscovite, intimately intergrown with the buddingtonite. The determinations on muscovite yielded an age of 1491 +/- 9 Ma, interpreted as the hydrothermal event forming the breccia. However, buddingtonite apparent ages yielded a range of 563 +/- 14 Ma down to 383 +/- 12 Ma, which are interpreted as reset ages due to Ar loss of the fibrous buddingtonite crystals during later heating. We conclude that buddingtonite is suited for Ar-40/Ar-39 age determinations as a supplementary method, together with other methods and minerals; however, it requires a detailed mineralogical characterization, and the ages will likely represent minimum ages.}, language = {en} } @article{PlatzWeckmannPeketal.2022, author = {Platz, Anna and Weckmann, Ute and Pek, Josef and Kovacikova, Svetlana and Klanica, Radek and Mair, Johannes and Aleid, Basel}, title = {3D imaging of the subsurface electrical resistivity structure in West Bohemia/Upper Palatinate covering mofettes and quaternary volcanic structures by using magnetotellurics}, series = {Tectonophysics : international journal of geotectonics and the geology and physics of the interior of the earth}, volume = {833}, journal = {Tectonophysics : international journal of geotectonics and the geology and physics of the interior of the earth}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0040-1951}, doi = {10.1016/j.tecto.2022.229353}, pages = {20}, year = {2022}, abstract = {The region of West Bohemia and Upper Palatinate belongs to the West Bohemian Massif. The study area is situated at the junction of three different Variscan tectonic units and hosts the ENE-WSW trending Ohre Rift as well as many different fault systems. The entire region is characterized by ongoing magmatic processes in the intra-continental lithospheric mantle expressed by a series of phenomena, including e.g. the occurrence of repeated earthquake swarms and massive degassing of mantle derived CO2 in form of mineral springs and mofettes. Ongoing active tectonics is mainly manifested by Cenozoic volcanism represented by different Quaternary volcanic structures. All these phenomena make the Ohre Rift a unique target area for European intra-continental geo-scientific research. With magnetotelluric (MT) measurements we image the subsurface distribution of the electrical resistivity and map possible fluid pathways. Two-dimensional (2D) inversion results by Munoz et al. (2018) reveal a conductive channel in the vicinity of the earthquake swarm region that extends from the lower crust to the surface forming a pathway for fluids into the region of the mofettes. A second conductive channel is present in the south of their model; however, their 2D inversions allow ambiguous interpretations of this feature. Therefore, we conducted a large 3D MT field experiment extending the study area towards the south. The 3D inversion result matches well with the known geology imaging different fluid/magma reservoirs at crust-mantle depth and mapping possible fluid pathways from the reservoirs to the surface feeding known mofettes and spas. A comparison of 3D and 2D inversion results suggests that the 2D inversion results are considerably characterized by 3D and off-profile structures. In this context, the new results advocate for the swarm earthquakes being located in the resistive host rock surrounding the conductive channels; a finding in line with observations e.g. at the San Andreas Fault, California.}, language = {en} } @article{AllroggenHeinckeKoyanetal.2022, author = {Allroggen, Niklas and Heincke, Bjorn H. and Koyan, Philipp and Wheeler, Walter and Ronning, Jan S.}, title = {3D ground-penetrating radar attribute classification}, series = {Geophysics}, volume = {87}, journal = {Geophysics}, number = {4}, publisher = {Society of Exploration Geophysicists}, address = {Tulsa}, issn = {0016-8033}, doi = {10.1190/GEO2021-0651.1}, pages = {WB19 -- WB30}, year = {2022}, abstract = {Ground-penetrating radar (GPR) is a method that can provide detailed information about the near subsurface in sedimentary and carbonate environments. The classical interpretation of GPR data (e.g., based on manual feature selection) often is labor-intensive and limited by the experience of the intercally used for seismic interpretation, can provide faster, more repeatable, and less biased interpretations. We have recorded a 3D GPD data set collected across a paleokarst breccia pipe in the Billefjorden area on Spitsbergen, Svalbard. After performing advanced processing, we compare the results of a classical GPR interpretation to the results of an attribute-based classification. Our attribute classification incorporates a selection of dip and textural attributes as the input for a k-means clustering approach. Similar to the results of the classical interpretation, the resulting classes differentiate between undisturbed strata and breccias or fault zones. The classes also reveal details inside the breccia pipe that are not discerned in the classical fer that the intrapipe GPR facies result from subtle differences, such as breccia lithology, clast size, or pore-space filling.}, language = {en} } @article{NadjafiBoesch2022, author = {Nadjafi-B{\"o}sch, Marie}, title = {30 Jahre Ratifizierung der UN-Kinderrechte}, series = {MenschenRechtsMagazin : MRM ; Informationen, Meinungen, Analysen}, volume = {27}, journal = {MenschenRechtsMagazin : MRM ; Informationen, Meinungen, Analysen}, number = {1}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1434-2820}, doi = {10.25932/publishup-57137}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-571370}, pages = {16 -- 26}, year = {2022}, language = {de} } @article{TitovKoppHocheetal.2022, author = {Titov, Evgenii and Kopp, Tristan and Hoche, Joscha and Humeniuk, Alexander and Mitrić, Roland}, title = {(De)localization dynamics of molecular excitons}, series = {Physical chemistry, chemical physics : PCCP ; a journal of European chemical societies}, volume = {24}, journal = {Physical chemistry, chemical physics : PCCP ; a journal of European chemical societies}, number = {20}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, issn = {1463-9076}, doi = {10.1039/d2cp00586g}, pages = {12136 -- 12148}, year = {2022}, abstract = {Molecular excitons play a central role in processes of solar energy conversion, both natural and artificial. It is therefore no wonder that numerous experimental and theoretical investigations in the last decade, employing state-of-the-art spectroscopic techniques and computational methods, have been driven by the common aim to unravel exciton dynamics in multichromophoric systems. Theoretically, exciton (de)localization and transfer dynamics are most often modelled using either mixed quantum-classical approaches (e.g., trajectory surface hopping) or fully quantum mechanical treatments (either using model diabatic Hamiltonians or direct dynamics). Yet, the terms such as "exciton localization" or "exciton transfer" may bear different meanings in different works depending on the method in use (quantum-classical vs. fully quantum). Here, we relate different views on exciton (de)localization. For this purpose, we perform molecular surface hopping simulations on several tetracene dimers differing by a magnitude of exciton coupling and carry out quantum dynamical as well as surface hopping calculations on a relevant model system. The molecular surface hopping simulations are done using efficient long-range corrected time-dependent density functional tight binding electronic structure method, allowing us to gain insight into different regimes of exciton dynamics in the studied systems.}, language = {en} } @article{Pezzini2022, author = {Pezzini, Giuseppe}, title = {(Classical) Narratives of Decline in Tolkien: Renewal, Accommodation, Focalisation}, series = {thersites 15}, volume = {2022}, journal = {thersites 15}, number = {15}, editor = {Amb{\"u}hl, Annemarie and Carl{\`a}-Uhink, Filippo and Rollinger, Christian and Walde, Christine}, issn = {2364-7612}, doi = {10.34679/thersites.vol15.213}, pages = {25 -- 51}, year = {2022}, abstract = {The paper investigates Tolkien's narratives of decline through the lens of their classical ancestry. Narratives of decline are widespread in ancient culture, in both philosophical and literary discourses. They normally posit a gradual degradation (moral and ontological) from an idealized Golden Age, which went hand-in-hand with increasing detachment of gods from mortal affairs. Narratives of decline are also at the core of Tolkien's mythology, constituting yet another underresearched aspect of classical influence on Tolkien. Such Classical narratives reverberate e.g. in Tolkien's division of Arda's history into ages, from an idealized First Age filled with Joy and Light to a Third Age, described as "Twilight Age (…) the first of the broken and changed world" (Letters 131). More generally, these narratives are related to Tolkien's notorious perception of history as a "long defeat" (Letters 195) and to that "heart-racking sense of the vanished past" which pervades Tolkien's works - the emotion which, in his words, moved him "supremely" and which he found "small difficulty in evoking" (Letters 91). The paper analyses the reception of narratives of decline in Tolkien's legendarium, pointing out similarities but also contrasts and differences, with the aim to discuss some key patterns of (classical) reception in Tolkien's theory and practice ('renewal', 'accommodation', 'focalization').}, language = {en} } @incollection{ProellerSiegel2022, author = {Proeller, Isabella and Siegel, John}, title = {'Tools' in public management}, series = {Elgar encyclopedia of public management}, booktitle = {Elgar encyclopedia of public management}, editor = {Schedler, Kuno}, publisher = {Edward Elgar Publishing}, address = {Cheltenham}, isbn = {978-1-80037-548-2}, doi = {10.4337/9781800375499.tools}, pages = {186 -- 190}, year = {2022}, abstract = {Tools are methods or procedures, and thus operational patterns of action, applied in public administrations to solve standard problems. It is also possible to consider them as structured communication according to professional standards aiming at complexity reduction. Regularly, tools in management stem on a deductive-synoptic rationale offering a seemingly 'objective' decision basis. They have a strong formative influence on the organization, regularly also beyond the intended effects. The prominence of tools is sometimes confused with management as such, e.g. introducing tools is mistaken as equivalent to managing for a particular purpose. However, tools have to be closely and carefully managed regarding the objectives and purposes they should serve.}, language = {en} } @book{DeekenHinzKlitschetal.2022, author = {Deeken, Johannes and Hinz, Carsten and Klitsch, Constantin and L{\"o}ffler, Robert and Penning, Isabelle and Richter, Christin and Sch{\"a}fer, David}, title = {\#Wirtschaft - Nordrhein-Westfalen}, number = {7/8}, editor = {Kirchner, Vera}, publisher = {Buchner}, address = {Bamberg}, isbn = {978-3-661-82252-5}, pages = {192}, year = {2022}, language = {de} } @book{KirchnerHinzAlischetal.2022, author = {Kirchner, Vera and Hinz, Carsten and Alisch, Julia and Hammer, Carolin and Klitsch, Constantin and L{\"o}ffler, Robert and Penning, Isabelle and Richter, Christin}, title = {\#WAT 1}, editor = {Kirchner, Vera}, publisher = {Buchner Verlag}, address = {Bamberg}, isbn = {978-3-661-82301-0}, pages = {288}, year = {2022}, language = {de} } @periodical{OPUS4-57206, title = {\#WAT}, series = {Forum Arbeitslehre : Zeitschrift f{\"u}r Berufsorientierung, Haushalt, Technik, Wirtschaft}, journal = {Forum Arbeitslehre : Zeitschrift f{\"u}r Berufsorientierung, Haushalt, Technik, Wirtschaft}, editor = {Kirchner, Vera}, publisher = {Gesellschaft f{\"u}r Arbeit, Technik, Wirtschaft im Unterricht (GATWU)}, address = {Berlin}, pages = {55 -- 56}, year = {2022}, language = {de} } @book{GaenzHinzHuhnetal.2022, author = {G{\"a}nz, Victoria and Hinz, Carsten and Huhn, Nicola and Klitsch, Constantin and L{\"o}ffler, Robert and Meis, Robin and Penning, Isabelle and Richter, Christin and Schellen, Ricarda and Schr{\"o}dter, Ayla and Schulz, Oliver and Simon, Veronika and Trojecka, Anetta and Verwohlt, Peter and Vogler, Christin and Vogt, Birgit}, title = {\#Gesellschaftslehre 7/8}, volume = {[Sch{\"u}lerband]}, publisher = {C.C. Buchner}, address = {Bamberg}, isbn = {978-3-661-70052-6}, pages = {400}, year = {2022}, language = {de} } @article{Kosman2022, author = {Kosman, Admiʾel}, title = {"אני מאמין" או "אנחנו מאמינים"? על האמונה של היהודי הדתי בארץ היום}, series = {אררט קיומי אררט כתב עת ליצירה}, journal = {אררט קיומי אררט כתב עת ליצירה}, number = {2}, year = {2022}, language = {mul} }