@article{FriemelMareljaLietal.2017,
  author    = {Friemel, Martin and Marelja, Zvonimir and Li, Kuanyu and Leimk{\"u}hler, Silke},
  title     = {The N-Terminus of Iron-Sulfur Cluster Assembly Factor ISD11 Is Crucial for Subcellular Targeting and Interaction with L-Cysteine Desulfurase NFS1},
  series = {Biochemistry},
  volume    = {56},
  journal   = {Biochemistry},
  publisher = {American Chemical Society},
  address   = {Washington},
  issn      = {0006-2960},
  doi       = {10.1021/acs.biochem.6b01239},
  pages     = {1797 -- 1808},
  year      = {2017},
  abstract  = {Assembly of iron sulfur (FeS) clusters is an important process in living cells. The initial sulfur mobilization step for FeS cluster biosynthesis is catalyzed by L-cysteine desulfurase NFS1, a reaction that is localized in mitochondria in humans. In humans, the function of NFS1 depends on the ISD11 protein, which is required to stabilize its structure. The NFS1/ISD11 complex further interacts with scaffold protein ISCU and regulator protein frataxin, thereby forming a quaternary complex for FeS cluster formation. It has been suggested that the role of ISD11 is not restricted to its role in stabilizing the structure of NFS1, because studies of single-amino acid variants of ISD11 additionally demonstrated its importance for the correct assembly of the quaternary complex. In this study, we are focusing on the N-terminal region of ISD11 to determine the role of N-terminal amino acids in the formation of the complex with NFS1 and to reveal the mitochondria) targeting sequence for subcellular localization. Our in vitro studies with the purified proteins and in vivo studies in a cellular system show that the first 10 N-terminal amino acids of ISD11 are indispensable for the activity of NFS1 and especially the conserved "LYR" motif is essential for the role of ISD11 in forming a stable and active complex with NFS1.},
  language  = {en}
}
@article{FruscalzoFrommerLonderoetal.2017,
  author    = {Fruscalzo, Arrigo and Frommer, Julia-Marie and Londero, Ambrogio P. and Henze, Andrea and Schweigert, Florian J. and Nofer, Jerzy-Roch and Steinhard, Johannes and Klockenbusch, Walter and Schmitz, Ralf and Raila, Jens},
  title     = {First trimester TTR-RBP4-ROH complex and angiogenic factors in the prediction of small for gestational age infant's outcome},
  series = {Archives of gynecology and obstetrics},
  volume    = {295},
  journal   = {Archives of gynecology and obstetrics},
  publisher = {Springer},
  address   = {Heidelberg},
  issn      = {0932-0067},
  doi       = {10.1007/s00404-017-4338-4},
  pages     = {1157 -- 1165},
  year      = {2017},
  abstract  = {To study the role of the TTR-RBP4-ROH complex components (transthyretin, serum retinol binding protein, retinol) and of angiogenic factors PlGF (placental growth factor) and sFlt-1 (soluble fms-like tyrosine kinase-1) in pregnancies complicated by small for gestational age infants (SGA). Case control study conducted on maternal serum collected between 11 + 0 to 13 + 6 weeks of gestation. TTR, RBP4, ROH, PlGF and sFlt-1 were measured in SGA patients (birth weight < 10\%) who delivered at term (n = 37) and before 37 weeks of gestation (n = 17) and in a matched control group with uneventful pregnancies (n = 37). We found decreased RBP4 in SGA patients that delivered fetuses < 3\% and in fetuses delivered after the 37 weeks of gestation compared to controls [1.50 (95\% CI 1.40-1.75) vs 1.62 (95\% CI 1.47-1.98), p < 0.05]. Further, we found lower PlGF and sFlt-1 concentrations in SGA that delivered before 37 weeks of gestation compared to controls (respectively, PIGF and sFlt-1: 39.7 pg/ml (95\% CI 32.3-66.3) vs 62.9 pg/ml (95\% CI 45.2-78.4) and 906 pg/ml (95\% CI 727-1626) vs 1610 pg/ml (95\% CI 1088-212), p < 0.05). First trimester maternal serum RBP4 and angiogenic factors PlGF and sFlt-1 can differently predict the timing of delivery of pregnancies complicated by SGA fetuses.},
  language  = {en}
}
@article{GallUebelEbensenetal.2017,
  author    = {Gall, Andrea and Uebel, Udo and Ebensen, Uwe and Hillebrand, Helmut and Meier, Sandra and Singer, Gabriel and Wacker, Alexander and Striebel, Maren},
  title     = {Planktotrons},
  series = {Limnology and oceanography-methods},
  volume    = {15},
  journal   = {Limnology and oceanography-methods},
  publisher = {Wiley},
  address   = {Hoboken},
  issn      = {1541-5856},
  doi       = {10.1002/lom3.10196},
  pages     = {663 -- 677},
  year      = {2017},
  abstract  = {We established a new indoor mesocosm facility, 12 fully controlled Planktotrons, designed to conduct marine and freshwater experiments for biodiversity and food web approaches using natural or artificial, benthic or planktonic communities. The Planktotrons are a unique and custom-tailored facility allowing long-term experiments. Wall growth can be inhibited by a rotating gate paddle with silicone lips. Additionally, temperature and light intensity are individually controllable for each Planktotron and the large volume (600 L) enables high-frequency or volume-intense measurements. In a pilot freshwater experiment various trophic levels of a pelagic food web were maintained for up to 90 d. First, an artificially assembled phytoplankton community of 11 species was inoculated in all Planktotrons. After 22 d, two ciliates were added to all, and three Daphnia species were added to six Planktotrons. After 72 d, dissolved organic matter (DOM, an alkaline soil extract) was added as an external disturbance to six of the 12 Planktotrons, involving three Planktotrons stocked with Daphnia and three without, respectively. We demonstrate the suitability of the Planktotrons for food web and biodiversity research. Variation among replicated Planktotrons (n=3 minimum) did not differ from other laboratory systems and field experiments. We investigated population dynamics and interactions among the different trophic levels, and found them affected by the sequence of ciliate and Daphnia addition and the disturbance caused by addition of DOM.},
  language  = {en}
}
@article{GietlerNykielOrzechowskietal.2017,
  author    = {Gietler, Marta and Nykiel, Malgorzata and Orzechowski, Slawomir and Fettke, J{\"o}rg and Zagdanska, Barbara},
  title     = {Protein carbonylation linked to wheat seedling tolerance to water deficiency},
  series = {Environmental and experimental botany},
  volume    = {137},
  journal   = {Environmental and experimental botany},
  publisher = {Elsevier},
  address   = {Oxford},
  issn      = {0098-8472},
  doi       = {10.1016/j.envexpbot.2017.02.004},
  pages     = {84 -- 95},
  year      = {2017},
  abstract  = {The appearance of the first leaf from the coleoptile in wheat seedlings (Triticum aestivum L.) coincides with the development of seedling susceptibility to water deficiency on the fifth day following imbibition. In dehydrated wheat seedlings, an increase in the protein carbonyl group has been observed. The coincidence of higher protein carbonylation levels with development of dehydration intolerance drew our attention. To gain more insight into the molecular basis of wheat drought tolerance, the seedling profiles of carbonylated proteins were analysed and compared. Two-dimensional gel electrophoresis (2D-PAGE) and mass spectrometry (MALDI-TOF and LC-MS/MS) were used to indicate and identify differential carbonylated proteins. Among the protein spots with at least a two-fold change in protein abundance in dehydrated seedlings in relation to control (well-watered) plants during the tolerant phase of growth, 19 carbonylated proteins increased and 18 carbonylated proteins decreased in abundance. Among 26 differentially expressed carbonylated proteins in sensitive seedlings, the abundance of 10 protein spots increased while that of 16 proteins decreased upon dehydration. We have demonstrated a link between protein carbonylation and seedling sensitivity to dehydration. The analysis of carbonylated protein profiles clearly showed that proteins with a potential role in the maintenance of dehydration tolerance in wheat seedlings are mainly linked to energy production, anti-fungal and/or insecticidal activity, or to the regulation of both protein synthesis and degradation.},
  language  = {en}
}
@article{GisderSchuelerHorchleretal.2017,
  author    = {Gisder, Sebastian and Sch{\"u}ler, Vivian and Horchler, Lennart L. and Groth, Detlef and Genersch, Elke},
  title     = {Long-Term Temporal Trends of Nosema spp. Infection Prevalence in Northeast Germany},
  series = {Frontiers in cellular and infection microbiology},
  volume    = {7},
  journal   = {Frontiers in cellular and infection microbiology},
  publisher = {Frontiers Research Foundation},
  address   = {Lausanne},
  issn      = {2235-2988},
  doi       = {10.3389/fcimb.2017.00301},
  pages     = {14},
  year      = {2017},
  abstract  = {The Western honey bee (Apis mellifera) is widely used as commercial pollinator in worldwide agriculture and, therefore, plays an important role in global food security. Among the parasites and pathogens threatening health and survival of honey bees are two species of microsporidia, Nosema apis and Nosema ceranae. Nosema ceranae is considered an emerging pathogen of the Western honey bee. Reports on the spread of N. ceranae suggested that this presumably highly virulent species is replacing its more benign congener N. apis in the global A. mellifera population. We here present a 12 year longitudinal cohort study on the prevalence of N. apis and N. ceranae in Northeast Germany. Between 2005 and 2016, a cohort of about 230 honey bee colonies originating from 23 apiaries was sampled twice a year (spring and autumn) resulting in a total of 5,600 bee samples which were subjected to microscopic and molecular analysis for determining the presence of infections with N. apis or/and N. ceranae. Throughout the entire study period, both N. apis- and N. ceranae-infections could be diagnosed within the cohort. Logistic regression analysis of the prevalence data demonstrated a significant increase of N. ceranae-infections over the last 12 years, both in autumn (reflecting the development during the summer) and in spring (reflecting the development over winter) samples. Cell culture experiments confirmed that N. ceranae has a higher proliferative potential than N. apis at 27. and 33 degrees C potentially explaining the increase in N. ceranae prevalence during summer. In autumn, characterized by generally low infection prevalence, this increase was accompanied by a significant decrease in N. apis- infection prevalence. In contrast, in spring, the season with a higher prevalence of infection, no significant decrease of N. apis infections despite a significant increase in N. ceranae infections could be observed. Therefore, our data do not support a general advantage of N. ceranae over N. apis and an overall replacement of N. apis by N. ceranae in the studied honey bee population.},
  language  = {en}
}
@article{GomulaKozielGrothetal.2017,
  author    = {Gomula, Aleksandra and Koziel, Slawomir and Groth, Detlef and Bielicki, Tadeusz},
  title     = {The effect of neighboring districts on body height of Polish conscripts},
  series = {Anthropologischer Anzeiger : journal of biological and clinical anthropology ; Mitteilungsorgan der Gesellschaft f{\"u}r Anthropologie},
  volume    = {74},
  journal   = {Anthropologischer Anzeiger : journal of biological and clinical anthropology ; Mitteilungsorgan der Gesellschaft f{\"u}r Anthropologie},
  number    = {1},
  publisher = {Schweizerbart},
  address   = {Stuttgart},
  issn      = {0003-5548},
  doi       = {10.1127/anthranz/2017/0701},
  pages     = {71 -- 76},
  year      = {2017},
  abstract  = {The aim of the study was to investigate the correlation of heights of conscripts living in neighboring districts in Poland. The study used 10\% of a nationally representative sample of 26,178 males 18.5-19.5 years old examined during the National survey of Polish conscripts conducted in 2001. The sample represented all regions and social strata of the country and included 354 different districts within 16 voivodships (provinces). Analyses were performed with the R statistical software. A small but significant correlation (0.24, p < 0.0001) was observed for height between 1st order neighboring districts. Correlations decreased with increased distances between neighboring districts, but remained significant for 7th node neighbors (0.18, p < 0.0001). Regarding voivodships (provinces), average height showed a geographical trend from the northwest (relatively tall) to the southeast (relatively short), and the correlation was stronger for first order neighboring provinces (0.796, p < 0.001). This study revealed clusters of tall people and short people, providing a support for hypothesis of the community effect in height. Small correlations between 1st order neighbors than in another country (Switzerland) may be associated with differences in geography, since in Poland there are no natural barriers (e.g., mountains) and road infrastructure is well-developed.},
  language  = {en}
}
@misc{GonzalezFortesTassiGhirottoetal.2017,
  author    = {Gonzalez-Fortes, Gloria M. and Tassi, Francesca and Ghirotto, Silvia and Henneberger, Kirstin and Hofreiter, Michael and Barbujani, Guido},
  title     = {The Neolithic transition at the Western edge of Europe},
  series = {American journal of physical anthropology},
  volume    = {162},
  journal   = {American journal of physical anthropology},
  publisher = {Wiley},
  address   = {Hoboken},
  issn      = {0002-9483},
  pages     = {198 -- 198},
  year      = {2017},
  language  = {en}
}
@article{Groth2017,
  author    = {Groth, Detlef},
  title     = {Modeling a secular trend by Monte Carlo simulation of height biased migration in a spatial network},
  series = {Anthropologischer Anzeiger : journal of biological and clinical anthropology ; Mitteilungsorgan der Gesellschaft f{\"u}r Anthropologie},
  volume    = {74},
  journal   = {Anthropologischer Anzeiger : journal of biological and clinical anthropology ; Mitteilungsorgan der Gesellschaft f{\"u}r Anthropologie},
  number    = {1},
  publisher = {Schweizerbart},
  address   = {Stuttgart},
  issn      = {0003-5548},
  doi       = {10.1127/anthranz/2017/0703},
  pages     = {81 -- 88},
  year      = {2017},
  abstract  = {Background: In a recent Monte Carlo simulation, the clustering of body height of Swiss military conscripts within a spatial network with characteristic features of the natural Swiss geography was investigated. In this study I examined the effect of migration of tall individuals into network hubs on the dynamics of body height within the whole spatial network. The aim of this study was to simulate height trends. Material and methods: Three networks were used for modeling, a regular rectangular fishing net like network, a real world example based on the geographic map of Switzerland, and a random network. All networks contained between 144 and 148 districts and between 265-307 road connections. Around 100,000 agents were initially released with average height of 170 cm, and height standard deviation of 6.5 cm. The simulation was started with the a priori assumption that height variation within a district is limited and also depends on height of neighboring districts (community effect on height). In addition to a neighborhood influence factor, which simulates a community effect, body height dependent migration of conscripts between adjacent districts in each Monte Carlo simulation was used to re-calculate next generation body heights. In order to determine the direction of migration for taller individuals, various centrality measures for the evaluation of district importance within the spatial network were applied. Taller individuals were favored to migrate more into network hubs, backward migration using the same number of individuals was random, not biased towards body height. Network hubs were defined by the importance of a district within the spatial network. The importance of a district was evaluated by various centrality measures. In the null model there were no road connections, height information could not be delivered between the districts. Results: Due to the favored migration of tall individuals into network hubs, average body height of the hubs, and later, of the whole network increased by up to 0.1 cm per iteration depending on the network model. The general increase in height within the network depended on connectedness and on the amount of height information that was exchanged between neighboring districts. If higher amounts of neighborhood height information were exchanged, the general increase in height within the network was large (strong secular trend). The trend in the homogeneous fishnet like network was lowest, the trend in the random network was highest. Yet, some network properties, such as the heteroscedasticity and autocorrelations of the migration simulation models differed greatly from the natural features observed in Swiss military conscript networks. Autocorrelations of district heights for instance, were much higher in the migration models. Conclusion: This study confirmed that secular height trends can be modeled by preferred migration of tall individuals into network hubs. However, basic network properties of the migration simulation models differed greatly from the natural features observed in Swiss military conscripts. Similar network-based data from other countries should be explored to better investigate height trends with Monte Carlo migration approach.},
  language  = {en}
}
@article{GuerreroRamirezCravenReichetal.2017,
  author    = {Guerrero-Ramirez, Nathaly Rokssana and Craven, Dylan and Reich, Peter B. and Ewel, John J. and Isbell, Forest and Koricheva, Julia and Parrotta, John A. and Auge, Harald and Erickson, Heather E. and Forrester, David I. and Hector, Andy and Joshi, Jasmin Radha and Montagnini, Florencia and Palmborg, Cecilia and Piotto, Daniel and Potvin, Catherine and Roscher, Christiane and van Ruijven, Jasper and Tilman, David and Wilsey, Brian and Eisenhauer, Nico},
  title     = {Diversity-dependent temporal divergence of ecosystem functioning in experimental ecosystems},
  series = {Nature ecology \& evolution},
  volume    = {1},
  journal   = {Nature ecology \& evolution},
  number    = {11},
  publisher = {Nature Publ. Group},
  address   = {London},
  issn      = {2397-334X},
  doi       = {10.1038/s41559-017-0325-1},
  pages     = {1639 -- 1642},
  year      = {2017},
  abstract  = {The effects of biodiversity on ecosystem functioning generally increase over time, but the underlying processes remain unclear. Using 26 long-term grassland and forest experimental ecosystems, we demonstrate that biodiversity-ecosystem functioning relationships strengthen mainly by greater increases in functioning in high-diversity communities in grasslands and forests. In grasslands, biodiversity effects also strengthen due to decreases in functioning in low-diversity communities. Contrasting trends across grasslands are associated with differences in soil characteristics.},
  language  = {en}
}
@phdthesis{Gorka2017,
  author    = {G{\´o}rka, Michal Jakub},
  title     = {Establishing a pipeline for identification of protein- protein interactions using different native fractionation methods},
  school      = {Universit{\"a}t Potsdam},
  pages     = {109},
  year      = {2017},
  language  = {en}
}
@article{HaaseKrostSauteretal.2017,
  author    = {Haase, Tobias and Krost, Annalena and Sauter, Tilman and Kratz, Karl and Peter, Jan and Kamann, Stefanie and Jung, Friedrich and Lendlein, Andreas and Zohlnh{\"o}fer, Dietlind and R{\"u}der, Constantin},
  title     = {In vivo biocompatibility assessment of poly (ether imide) electrospun scaffolds},
  series = {Journal of Tissue Engineering and Regenerative Medicine},
  volume    = {11},
  journal   = {Journal of Tissue Engineering and Regenerative Medicine},
  number    = {4},
  publisher = {Wiley},
  address   = {Hoboken},
  issn      = {1932-6254},
  doi       = {10.1002/term.2002},
  pages     = {1034 -- 1044},
  year      = {2017},
  abstract  = {Poly(ether imide) (PEI), which can be chemically functionalized with biologically active ligands, has emerged as a potential biomaterial for medical implants. Electrospun PEI scaffolds have shown advantageous properties, such as enhanced endothelial cell adherence, proliferation and low platelet adhesion in in vitro experiments. In this study, the in vivo behaviour of electrospun PEI scaffolds and PEI films was examined in a murine subcutaneous implantation model. Electrospun PEI scaffolds and films were surgically implanted subcutaneously in the dorsae of mice. The surrounding subcutaneous tissue response was examined via histopathological examination at 7 and 28days after implantation. No serious adverse events were observed for both types of PEI implants. The presence of macrophages or foreign body giant cells in the vicinity of the implants and the formation of a fibrous capsule indicated a normal foreign body reaction towards PEI films and scaffolds. Capsule thickness and inflammatory infiltration cells significantly decreased for PEI scaffolds during days 7-28 while remaining unchanged for PEI films. The infiltration of cells into the implant was observed for PEI scaffolds 7days after implantation and remained stable until 28days of implantation. Additionally some, but not all, PEI scaffold implants induced the formation of functional blood vessels in the vicinity of the implants. Conclusively, this study demonstrates the in vivo biocompatibility of PEI implants, with favourable properties of electrospun PEI scaffolds regarding tissue integration and wound healing.},
  language  = {en}
}
@article{HahnMeyerSchroeteretal.2017,
  author    = {Hahn, Marc Benjamin and Meyer, Susann and Schr{\"o}ter, Maria-Astrid and Seitz, Harald and Kunte, Hans-J{\"o}rg and Solomun, Tihomir and Sturm, Heinz},
  title     = {Direct electron irradiation of DNA in a fully aqueous environment},
  series = {Physical chemistry, chemical physics : PCCP ; a journal of European chemical societies},
  volume    = {19},
  journal   = {Physical chemistry, chemical physics : PCCP ; a journal of European chemical societies},
  number    = {3},
  publisher = {RSC Publ.},
  address   = {Cambridge},
  issn      = {1463-9076},
  doi       = {10.1039/c6cp07707b},
  pages     = {1798 -- 1805},
  year      = {2017},
  abstract  = {We report on a study in which plasmid DNA in water was irradiated with 30 keV electrons generated by a scanning electron microscope and passed through a 100 nm thick Si3N4 membrane. The corresponding Monte Carlo simulations suggest that the kinetic energy spectrum of the electrons throughout the water is dominated by low energy electrons (<100 eV). The DNA radiation damage, single-strand breaks (SSBs) and double-strand breaks (DSBs), was determined by gel electrophoresis. The median lethal dose of D-1/2 = 1.7 +/- 0.3 Gy was found to be much smaller as compared to partially or fully hydrated DNA irradiated under vacuum conditions. The ratio of the DSBs to SSBs was found to be 1 : 12 as compared to 1 : 88 found for hydrated DNA. Our method enables quantitative measurements of radiation damage to biomolecules (DNA, proteins) in solutions under varying conditions (pH, salinity, co-solutes) for an electron energy range which is difficult to probe by standard methods.},
  language  = {en}
}
@article{HansenMeyerFerrarietal.2017,
  author    = {Hansen, Bjoern Oest and Meyer, Etienne H. and Ferrari, Camilla and Vaid, Neha and Movahedi, Sara and Vandepoele, Klaas and Nikoloski, Zoran and Mutwil, Marek},
  title     = {Ensemble gene function prediction database reveals genes important for complex I formation in Arabidopsis thaliana},
  series = {New phytologist : international journal of plant science},
  volume    = {217},
  journal   = {New phytologist : international journal of plant science},
  number    = {4},
  publisher = {Wiley},
  address   = {Hoboken},
  issn      = {0028-646X},
  doi       = {10.1111/nph.14921},
  pages     = {1521 -- 1534},
  year      = {2017},
  abstract  = {Recent advances in gene function prediction rely on ensemble approaches that integrate results from multiple inference methods to produce superior predictions. Yet, these developments remain largely unexplored in plants. We have explored and compared two methods to integrate 10 gene co-function networks for Arabidopsis thaliana and demonstrate how the integration of these networks produces more accurate gene function predictions for a larger fraction of genes with unknown function. These predictions were used to identify genes involved in mitochondrial complex I formation, and for five of them, we confirmed the predictions experimentally. The ensemble predictions are provided as a user-friendly online database, EnsembleNet. The methods presented here demonstrate that ensemble gene function prediction is a powerful method to boost prediction performance, whereas the EnsembleNet database provides a cutting-edge community tool to guide experimentalists.},
  language  = {en}
}
@misc{HasanHocher2017,
  author    = {Hasan, Ahmed Abdallah Abdalrahman Mohamed and Hocher, Berthold},
  title     = {Role of soluble and membrane-bound dipeptidyl peptidase-4 in diabetic nephropathy},
  series = {Journal of Molecular Endocrinology},
  volume    = {59},
  journal   = {Journal of Molecular Endocrinology},
  publisher = {Bioscientifica LTD},
  address   = {Bristol},
  issn      = {0952-5041},
  doi       = {10.1530/JME-17-0005},
  pages     = {R1 -- R10},
  year      = {2017},
  abstract  = {Diabetic nephropathy is one of the most frequent, devastating and costly complications of diabetes. The available therapeutic approaches are limited. Dipeptidyl peptidase type 4 (DPP-4) inhibitors represent a new class of glucose-lowering drugs that might also have reno-protective properties. DPP-4 exists in two forms: a plasma membranebound form and a soluble form, and can exert many biological actions mainly through its peptidase activity and interaction with extracellular matrix components. The kidneys have the highest DPP-4 expression level in mammalians. DPP-4 expression and urinary activity are up-regulated in diabetic nephropathy, highlighting its role as a potential target to manage diabetic nephropathy. Preclinical animal studies and some clinical data suggest that DPP-4 inhibitors decrease the progression of diabetic nephropathy in a blood pressure-and glucose-independent manner. Many studies reported that these reno-protective effects could be due to increased half-life of DPP-4 substrates such as glucagon-like peptide-1 (GLP-1) and stromal derived factor-1 alpha (SDF-1a). However, the underlying mechanisms are far from being completely understood and clearly need further investigations.},
  language  = {en}
}
@phdthesis{Heim2017,
  author    = {Heim, Olga},
  title     = {Spatiotemporal effects on bat activity above intensively managed farmland},
  school      = {Universit{\"a}t Potsdam},
  pages     = {ii, 150},
  year      = {2017},
  abstract  = {Intakte und widerstandsf{\"a}hige {\"O}kosysteme sind essenziell f{\"u}r die Aufrechterhaltung optimaler Lebensbedingungen f{\"u}r das Leben auf der Erde. Die Basis f{\"u}r solche {\"O}kosysteme bilden intakte {\"o}kologische Wechselwirkungen zwischen einer Vielzahl von Arten. Durch den beispiellosen Verlust der Biodiversit{\"a}t, welcher durch die in der zweiten H{\"a}lfte des 20. Jahrhunderts zunehmende Intensivierung der Agrarwirtschaft und die Zerst{\"o}rung und Fragmentierung von Habitaten hervorgerufen wurde, k{\"o}nnen {\"o}kologische Wechselwirkungen und damit die Funktionsf{\"a}higkeit von Agrar{\"o}kosystemen stark eingeschr{\"a}nkt werden. Um den R{\"u}ckgang der Biodiversit{\"a}t in Agrar{\"o}kosystemen abschw{\"a}chen zu k{\"o}nnen, m{\"u}ssen wir die {\"o}kologischen Wechselwirkungen in Agrar{\"o}kosystemen besser verstehen. Hierbei spielen Flederm{\"a}use eine besondere Rolle, weil sie verschiedenste {\"o}kologische Nischen besetzen und eine Reihe von {\"O}kosystemleistungen erf{\"u}llen so wie z.B. die Kontrolle von Sch{\"a}dlingspopulationen in Agrarlandschaften. {\"U}berdies tr{\"a}gt die Ordnung der Flederm{\"a}use (Chiroptera) betr{\"a}chtlich zur globalen Diversit{\"a}t der S{\"a}ugetiere bei. Obwohl viele Fledermauspopulationen durch die Intensivierung der Agrarwirtschaft dezimiert wurden, ist noch relativ wenig dar{\"u}ber bekannt wie unterschiedliche Fledermausarten die offene Agrarlandschaft nutzen. Dieses Wissen ist jedoch essenziell f{\"u}r den Schutz von Fledermausarten in intensiv bewirtschafteten Agrarlandschaften und dringend notwendig besonders vor dem Hintergrund der vorhergesagten erweiterten Ausweitung der intensiven Agrarwirtschaft. Zus{\"a}tzlich werden Flederm{\"a}use durch den zuletzt massiven Ausbau von Windkraftanlagen, welche f{\"u}r viele Vogel- und Fledermausarten ein erh{\"o}htes T{\"o}tungsrisiko darstellen, bedroht. Das Ziel dieser Dissertation war es deshalb, die Einfl{\"u}sse ausgew{\"a}hlter raum-zeitlicher Faktoren auf die artspezifische Fledermausaktivit{\"a}t {\"u}ber intensiv genutzten Agrarfl{\"a}chen in einer von Agrarwirtschaft dominierten Landschaft zu untersuchen. Dazu habe ich die Fledermausaktivit{\"a}t mittels passiver akustischer Echoortungsaufnahme in den Jahren 2012 bis 2014 auf insgesamt 113 Untersuchungsfl{\"a}chen in offenen Ackerfl{\"a}chen im Nordosten Brandenburgs erfasst. Die Echoortungsrufe in etwa 27.779 Aufnahmen habe ich manuell bis auf die Art bestimmt und die berechneten artspezifischen Aktivit{\"a}tsparameter mit Hilfe von komplexen statistischen Verfahren untersucht. Im ersten Kapitel dieser Arbeit, habe ich die berechneten Aktivit{\"a}tsparameter von {\"o}kologisch unterschiedlichen Fledermausgruppen auf saisonale Muster hin untersucht. Dabei war ich besonders an Unterschieden zu den bekannten saisonalen Aktivit{\"a}tsmustern in naturnahen Habitaten interessiert. Im zweiten Kapitel dieser Arbeit, habe ich den Einfluss von linearen Geh{\"o}lzstrukturen am Feldrand und von kleinen Wasserfl{\"a}chen (S{\"o}llen) innerhalb von Ackerfl{\"a}chen auf die Flug- und Jagdaktivit{\"a}t verschiedener Fledermausarten {\"u}ber diesen Fl{\"a}chen untersucht. Zus{\"a}tzlich war ich daran interessiert, ob sich etwaige Effekte dieser Landschaftselemente auf die Fledermausaktivit{\"a}t im Laufe des Jahres ver{\"a}ndern. Im dritten Kapitel dieser Arbeit war es mein Ziel den Zusammenhang zwischen unterschiedlichen r{\"a}umlichen und zeitlichen Einfl{\"u}ssen auf die artspezifische Fledermausaktivit{\"a}t {\"u}ber offenen Agrarfl{\"a}chen zu untersuchen. Dabei habe ich meine Untersuchungen auf Faktoren fokussiert, die daf{\"u}r bekannt sind Fledermausaktivit{\"a}t zu beeinflussen, wie z.B. Faktoren auf kleinr{\"a}umiger Skala, die mit der Beuteverf{\"u}gbarkeit zusammenh{\"a}ngen, und verschiedene Landschaftscharakteristika auf großr{\"a}umiger Skala. Auf der zeitlichen Skala, habe ich mich auf den Einfluss der Saison konzentriert. Zusammenfassend heben die Ergebnisse dieser Arbeit die Wichtigkeit naturnaher Landschaftselemente f{\"u}r die Fledermausaktivit{\"a}t {\"u}ber Agrarfl{\"a}chen hervor. Allerdings war nicht nur die Landschaftsstruktur f{\"u}r die Fledermausaktivit{\"a}t {\"u}ber Ackerfl{\"a}chen ausschlaggebend, sondern auch der Einfluss von interaktiven Effekten zwischen z.B. Landschaftscharakteristika und der lokalen Beuteverf{\"u}gbarkeit. Ein weiteres Kernergebnis ist die saisonale Variabilit{\"a}t des Einflusses der Landschaftsstruktur auf die Fledermausaktivit{\"a}t. Hierbei hatten bestimmte Landschaftselemente vor allem im Sommer einen großen Einfluss auf die Fledermausaktivit{\"a}t. Das Potenzial der {\"O}kosystemleistung durch spezifische Fledermausarten, welches wiederholt in den unterschiedlichen Kapiteln hervorgehoben wurde, ist ein weiteres Kernergebnis. Da die Fledermausaktivit{\"a}t jedoch stark von der Landschaftsstruktur in der Umgebung abh{\"a}ngt, ist es wichtig diese fledermausfreundlich zu gestalten, um die {\"O}kosystemleistung der Sch{\"a}dlingskontrolle {\"u}ber Agrarfl{\"a}chen nutzen zu k{\"o}nnen. Schlussendlich tr{\"a}gt diese Arbeit in ihrer Gesamtheit zum bestehenden Wissen {\"u}ber die Fledermausbiologie und -{\"o}kologie bei und verdeutlicht die komplexen Wechselwirkungen unterschiedlicher Einfl{\"u}sse auf mehreren raum-zeitlichen Ebenen. Die Ergebnisse dieser Arbeit k{\"o}nnen als Basis zur Verbesserung und Entwicklung von Schutzmaßnahmen f{\"u}r Flederm{\"a}use in intensiv genutzten Agrarlandschaften dienen. Da Flederm{\"a}use als gute Bioindikatoren gelten, k{\"o}nnen effektive Schutzmaßnahmen f{\"u}r Flederm{\"a}use auch zum Schutz anderer Arten beitragen und damit potenziell den weiteren Verlust der Biodiversit{\"a}t in Agrarlandschaften abschw{\"a}chen.},
  language  = {en}
}
@article{HeimLenskiSchulzeetal.2017,
  author    = {Heim, Olga and Lenski, Johannes and Schulze, Jelena and Jung, Kirsten and Kramer-Schadt, Stephanie and Eccard, Jana and Voigt, Christian C.},
  title     = {The relevance of vegetation structures and small water bodies for bats foraging above farmland},
  series = {Basic and applied ecology : Journal of the Gesellschaft f{\"u}r {\"O}kologie},
  volume    = {27},
  journal   = {Basic and applied ecology : Journal of the Gesellschaft f{\"u}r {\"O}kologie},
  publisher = {Elsevier GMBH},
  address   = {M{\"u}nchen},
  issn      = {1439-1791},
  doi       = {10.1016/j.baae.2017.12.001},
  pages     = {9 -- 19},
  year      = {2017},
  abstract  = {Bats are known to forage and commute close to vegetation structures when moving across the agricultural matrix, but the role of isolated landscape elements in arable fields for bat activity is unknown. Therefore, we investigated the influence of small isolated ponds which lie within arable fields close to vegetation structures on the flight and foraging activity of bats. Additionally, we compared species-specific activity measures between forest edges and linear structures such as hedgerows. We repeatedly recorded bat activity using passive acoustic monitoring along 20 transects extending from the vegetation edge up to 200 m into the arable field (hereafter: edge-field interface) with a small pond present at five transects per edge type (linear vs. forest). Using generalized linear mixed effect models, we analyzed the effects of edge type, pond presence and the season on species-specific flight and foraging activity within the edge-field interface. We found a higher flight activity of Nyctalus noctula and Pipistrellus pygmaeus above the arable field when a pond was present. Furthermore, Pipistrellus nathusii and Pipistrellus pipistrellus foraged more frequently at forest edges than at linear structures (e.g. hedgerows). Additionally, we found three major patterns of seasonal variation in the activity of bats along the edge-field interface. This study highlights the species-specific and dynamic use of forest and hedgerow or tree line edges by bats and their importance for different bat species in the agricultural landscape. Further, additional landscape elements such as small isolated ponds within arable fields might support the activity of bats above the open agricultural landscape, thereby facilitating agroecosystem functioning. Therefore, additional landscape elements within managed areas should be restored and protected against the conversion into arable land and better linked to surrounding landscape elements in order to efficiently support bats within the agroecosystem.},
  language  = {en}
}
@article{HeimTrenseSokolovaetal.2017,
  author    = {Heim, Wieland and Trense, Daronja and Sokolova, Galina V. and Kitagawa, Tamaki},
  title     = {Increased populations of endangered cranes after Amur River flood},
  series = {Waterbirds},
  volume    = {40},
  journal   = {Waterbirds},
  publisher = {Waterbirds SOC},
  address   = {Washington},
  issn      = {1524-4695},
  doi       = {10.1675/063.040.0309},
  pages     = {282 -- 288},
  year      = {2017},
  abstract  = {Dam construction on the Zeya River, which is an important tributary of the Amur River in Far East Russia, has caused significant declines in water levels and frequency of floods in the adjacent floodplains since 1980. However, an extreme flood event occurred in 2013. Populations of six crane species were monitored before and after these drastic water level changes at Muraviovka Park in Far East Russia, an important breeding and stop-over site. Individuals were counted by territory mapping during the breeding season (2000-2015) and by roosting site counts during autumn migration (2006-2015). The objective of this study was to evaluate whether changes in water levels had a significant impact on local and migratory crane populations. We found a positive effect of flooding on numbers of breeding Red-crowned Cranes (Grus japonensis) and White-naped Cranes (Antigone vipio), as well as on numbers of roosting Hooded Cranes (Grus monacha) in autumn. Siberian Cranes (Leucogeranus leucogeranus) were only observed after the wetlands were flooded. The results of this study highlight the importance of elevated Amur River water levels for crane populations of global importance.},
  language  = {en}
}
@article{HeinzeJoshi2017,
  author    = {Heinze, Johannes and Joshi, Jasmin Radha},
  title     = {Plant-soil feedback effects can be masked by aboveground herbivory under natural field conditions},
  series = {Oecologia},
  volume    = {186},
  journal   = {Oecologia},
  number    = {1},
  publisher = {Springer},
  address   = {New York},
  issn      = {0029-8549},
  doi       = {10.1007/s00442-017-3997-y},
  pages     = {235 -- 246},
  year      = {2017},
  abstract  = {For plants, herbivory and interactions with their surrounding soil ecosystem are crucial factors influencing individual performance and plant-community composition. Until now, research has mostly focused on individual effects of herbivory or plant-soil feedbacks (PSFs) on plant growth and community composition, but few studies have explicitly investigated herbivory in the context of PSFs. These few studies, however, were performed under greenhouse conditions even though PSFs and herbivory may differ between greenhouse and field conditions. Therefore, we performed a field experiment in a grassland, testing the growth responses of three grass species that consistently differ in local abundance, on soils previously conditioned by these species. We tested these PSF effects for the three species both in the presence and in the absence of aboveground herbivores. Without herbivores, the two subdominant species suffered from negative PSF effects. However, in the presence of herbivores and on heterospecific soils, the same two species experienced a significant loss of shoot biomass, whereas, in contrast, enhanced root growth was observed on conspecific soils, resulting in overall neutral PSF effects. The dominant species was not damaged by herbivores and showed overall neutral PSF effects in the field with and without herbivores. Our study provides empirical evidence that negative PSF effects that exist under natural field conditions in grasslands can be overwhelmed by aboveground herbivory. Hence, potential PSF effects might not be detected in the field, because other abiotic and biotic interactions such as aboveground herbivory have stronger effects on plant performance and might therefore mask or override these PSF effects.},
  language  = {en}
}
@article{HenkelColemanSchraplauetal.2017,
  author    = {Henkel, Janin and Coleman, Charles Dominic and Schraplau, Anne and J{\"o}hrens, Korinna and Weber, Daniela and Castro, Jose Pedro and Hugo, Martin and Schulz, Tim Julius and Kr{\"a}mer, Stephanie and Sch{\"u}rmann, Annette and P{\"u}schel, Gerhard Paul},
  title     = {Induction of Steatohepatitis (NASH) with Insulin Resistance in Wild-type B6 Mice by a Western-type Diet Containing Soybean Oil and Cholesterol},
  series = {Molecular medicine},
  volume    = {23},
  journal   = {Molecular medicine},
  publisher = {Feinstein Inst. for Medical Research},
  address   = {Manhasset},
  issn      = {1076-1551},
  doi       = {10.2119/molmed.2016.00203},
  pages     = {70 -- 82},
  year      = {2017},
  abstract  = {Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are hepatic manifestations of the metabolic syndrome. Many currently used animal models of NAFLD/NASH lack clinical features of either NASH or metabolic syndrome such as hepatic inflammation and fibrosis (e.g., high-fat diets) or overweight and insulin resistance (e.g., methionine-choline-deficient diets), or they are based on monogenetic defects (e.g., ob/ob mice). In the current study, a Western-type diet containing soybean oil with high n-6-PUFA and 0.75\% cholesterol (SOD + Cho) induced steatosis, inflammation and fibrosis accompanied by hepatic lipid peroxidation and oxidative stress in livers of C57BL/6-mice, which in addition showed increased weight gain and insulin resistance, thus displaying a phenotype closely resembling all clinical features of NASH in patients with metabolic syndrome. In striking contrast, a soybean oil-containing Western-type diet without cholesterol (SOD) induced only mild steatosis but not hepatic inflammation, fibrosis, weight gain or insulin resistance. Another high-fat diet, mainly consisting of lard and supplemented with fructose in drinking water (LAD + Fru), resulted in more prominent weight gain, insulin resistance and hepatic steatosis than SOD + Cho, but livers were devoid of inflammation and fibrosis. Although both LAD + Fru-and SOD + Cho-fed animals had high plasma cholesterol, liver cholesterol was elevated only in SOD + Cho animals. Cholesterol induced expression of chemotactic and inflammatory cytokines in cultured Kupffer cells and rendered hepatocytes more susceptible to apoptosis. In summary, dietary cholesterol in the SOD + Cho diet may trigger hepatic inflammation and fibrosis. SOD + Cho-fed animals may be a useful disease model displaying many clinical features of patients with the metabolic syndrome and NASH.},
  language  = {en}
}
@article{HeunischChaykovskavonEinemetal.2017,
  author    = {Heunisch, Fabian and Chaykovska, Lyubov and von Einem, Gina and Alter, Markus and Dschietzig, Thomas and Kretschmer, Axel and Kellner, Karl-Heinz and Hocher, Berthold},
  title     = {ADMA predicts major adverse renal events in patients with mild renal impairment and/or diabetes mellitus undergoing coronary angiography},
  series = {Medicine},
  volume    = {96},
  journal   = {Medicine},
  number    = {6},
  publisher = {Lippincott Williams \& Wilkins},
  address   = {Philadelphia},
  issn      = {0025-7974},
  doi       = {10.1097/MD.0000000000006065},
  pages     = {7},
  year      = {2017},
  abstract  = {Asymmetric dimethylarginine (ADMA) is a competitive inhibitor of the nitric oxide (NO)-synthase and a biomarker of endothelial dysfunction (ED). ED plays an important role in the pathogenesis of contrast-induced nephropathy (CIN). The aim of our study was to evaluate serum ADMA concentration as a biomarker of an acute renal damage during the follow-up of 90 days after contrast medium (CM) application. Blood samples were obtained from 330 consecutive patients with diabetes mellitus or mild renal impairment immediately before, 24 and 48 hours after the CM application for coronary angiography. The patients were followed for 90 days. The composite endpoints were major adverse renal events (MARE) defined as occurrence of death, initiation of dialysis, or a doubling of serum creatinine concentration. Overall, ADMA concentration in plasma increased after CM application, although, there was no differences between ADMA levels in patients with and without CIN. ADMA concentration 24 hours after the CM application was predictive for dialysis with a specificity of 0.889 and sensitivity of 0.653 at values higher than 0.71 mu mol/L (area under the curve: 0.854, 95\% confidential interval: 0.767-0.941, P<0.001). This association remained significant in multivariate Cox regression models adjusted for relevant factors of long-term renal outcome. 24 hours after the CM application, ADMA concentration in plasma was predictive for MARE with a specificity of 0.833 and sensitivity of 0.636 at a value of more than 0.70 mu mol/L (area under the curve: 0.750, 95\% confidence interval: 0.602-0.897, P=0.004). Multivariate logistic regression analysis confirmed that ADMA and anemia were significant predictors of MARE. Further analysis revealed that increased ADMA concentration in plasma was highly significant predictor of MARE in patients with CIN. Moreover, patients with CIN and MARE had the highest plasma ADMA levels 24 hours after CM exposure in our study cohort. The impact of ADMA on MARE was independent of such known CIN risk factors as anemia, pre-existing renal failure, pre-existing heart failure, and diabetes. ADMA concentration in plasma is a promising novel biomarker of major contrast-induced nephropathy-associated events 90 days after contrast media exposure.},
  language  = {en}
}
@article{HoehnJerniganJaptoketal.2017,
  author    = {Hoehn, Richard S. and Jernigan, Peter L. and Japtok, Lukasz and Chang, Alex L. and Midura, Emily F. and Caldwell, Charles C. and Kleuser, Burkhard and Lentsch, Alex B. and Edwards, Michael J. and Gulbins, Erich and Pritts, Timothy A.},
  title     = {Acid sphingomyelinase inhibition in stored erythrocytes reduces transfusion-associated lung inflammation},
  series = {Annals of surgery : a monthly review of surgical science and practice},
  volume    = {265},
  journal   = {Annals of surgery : a monthly review of surgical science and practice},
  number    = {1},
  publisher = {Lippincott Williams \& Wilkins},
  address   = {Philadelphia},
  issn      = {0003-4932},
  doi       = {10.1097/SLA.0000000000001648},
  pages     = {218 -- 226},
  year      = {2017},
  abstract  = {Objective: We aimed to identify the role of the enzyme acid sphingomyelinase in the aging of stored units of packed red blood cells (pRBCs) and subsequent lung inflammation after transfusion. Summary Background Data: Large volume pRBC transfusions are associated with multiple adverse clinical sequelae, including lung inflammation. Microparticles are formed in stored pRBCs over time and have been shown to contribute to lung inflammation after transfusion. Methods: Human and murine pRBCs were stored with or without amitriptyline, a functional inhibitor of acid sphingomyelinase, or obtained from acid sphingomyelinase-deficient mice, and lung inflammation was studied in mice receiving transfusions of pRBCs and microparticles isolated from these units. Results: Acid sphingomyelinase activity in pRBCs was associated with the formation of ceramide and the release of microparticles. Treatment of pRBCs with amitriptyline inhibited acid sphingomyelinase activity, ceramide accumulation, and microparticle production during pRBC storage. Transfusion of aged pRBCs or microparticles isolated from aged blood into mice caused lung inflammation. This was attenuated after transfusion of pRBCs treated with amitriptyline or from acid sphingomyelinase-deficient mice. Conclusions: Acid sphingomyelinase inhibition in stored pRBCs offers a novel mechanism for improving the quality of stored blood.},
  language  = {en}
}
@article{HolzloehnerHanack2017,
  author    = {Holzl{\"o}hner, Pamela and Hanack, Katja},
  title     = {Generation of murine monoclonal antibodies by hybridoma technology},
  series = {JoVE : Video journal},
  journal   = {JoVE : Video journal},
  number    = {119},
  publisher = {JoVE},
  address   = {Cambridge},
  issn      = {1940-087X},
  doi       = {10.3791/54832},
  pages     = {7},
  year      = {2017},
  abstract  = {Monoclonal antibodies are universal binding molecules and are widely used in biomedicine and research. Nevertheless, the generation of these binding molecules is time-consuming and laborious due to the complicated handling and lack of alternatives. The aim of this protocol is to provide one standard method for the generation of monoclonal antibodies using hybridoma technology. This technology combines two steps. Step 1 is an appropriate immunization of the animal and step 2 is the fusion of B lymphocytes with immortal myeloma cells in order to generate hybrids possessing both parental functions, such as the production of antibody molecules and immortality. The generated hybridoma cells were then recloned and diluted to obtain stable monoclonal cell cultures secreting the desired monoclonal antibody in the culture supernatant. The supernatants were tested in enzyme-linked immunosorbent assays (ELISA) for antigen specificity. After the selection of appropriate cell clones, the cells were transferred to mass cultivation in order to produce the desired antibody molecule in large amounts. The purification of the antibodies is routinely performed by affinity chromatography. After purification, the antibody molecule can be characterized and validated for the final test application. The whole process takes 8 to 12 months of development, and there is a high risk that the antibody will not work in the desired test system.},
  language  = {en}
}
@article{HornickBachCrawfurdetal.2017,
  author    = {Hornick, Thomas and Bach, Lennart T. and Crawfurd, Katharine J. and Spilling, Kristian and Achterberg, Eric P. and Woodhouse, Jason Nicholas and Schulz, Kai G. and Brussaard, Corina P. D. and Riebesell, Ulf and Grossart, Hans-Peter},
  title     = {Ocean acidification impacts bacteria-phytoplankton coupling at low-nutrient conditions},
  series = {Biogeosciences},
  volume    = {14},
  journal   = {Biogeosciences},
  number    = {1},
  publisher = {Copernicus},
  address   = {G{\"o}ttingen},
  issn      = {1726-4170},
  doi       = {10.5194/bg-14-1-2017},
  pages     = {1 -- 15},
  year      = {2017},
  abstract  = {The oceans absorb about a quarter of the annually produced anthropogenic atmospheric carbon dioxide (CO2), resulting in a decrease in surface water pH, a process termed ocean acidification (OA). Surprisingly little is known about how OA affects the physiology of heterotrophic bacteria or the coupling of heterotrophic bacteria to phytoplankton when nutrients are limited. Previous experiments were, for the most part, undertaken during productive phases or following nutrient additions designed to stimulate algal blooms. Therefore, we performed an in situ large-volume mesocosm (similar to 55 m(3)) experiment in the Baltic Sea by simulating different fugacities of CO2 (fCO(2)) extending from present to future conditions. The study was conducted in July-August after the nominal spring bloom, in order to maintain low-nutrient conditions throughout the experiment. This resulted in phytoplankton communities dominated by small-sized functional groups (picophytoplankton). There was no consistent fCO(2)-induced effect on bacterial protein production (BPP), cell-specific BPP (csBPP) or biovolumes (BVs) of either free-living (FL) or particle-associated (PA) heterotrophic bacteria, when considered as individual components (univariate analyses). Permutational Multivariate Analysis of Variance (PERMANOVA) revealed a significant effect of the fCO(2) treatment on entire assemblages of dissolved and particulate nutrients, metabolic parameters and the bacteria-phytoplankton community. However, distance-based linear modelling only identified fCO(2) as a factor explaining the variability observed amongst the microbial community composition, but not for explaining variability within the metabolic parameters. This suggests that fCO(2) impacts on microbial metabolic parameters occurred indirectly through varying physicochemical parameters and microbial species composition. Cluster analyses examining the co-occurrence of different functional groups of bacteria and phytoplankton further revealed a separation of the four fCO(2)-treated mesocosms from both control mesocosms, indicating that complex trophic interactions might be altered in a future acidified ocean. Possible consequences for nutrient cycling and carbon export are still largely unknown, in particular in a nutrient-limited ocean.},
  language  = {en}
}
@article{IetswaartRosaWuetal.2017,
  author    = {Ietswaart, Robert and Rosa, Stefanie and Wu, Zhe and Dean, Caroline and Howard, Martin},
  title     = {Cell-Size-Dependent Transcription of FLC and Its Antisense Long Non-coding RNA COOLAIR Explain Cell-to-Cell Expression Variation},
  series = {Cell systems},
  volume    = {4},
  journal   = {Cell systems},
  publisher = {Cell Press},
  address   = {Cambridge},
  issn      = {2405-4712},
  doi       = {10.1016/j.cels.2017.05.010},
  pages     = {622 -- 635},
  year      = {2017},
  abstract  = {Single-cell quantification of transcription kinetics and variability promotes a mechanistic understanding of gene regulation. Here, using single-molecule RNA fluorescence in situ hybridization and mathematical modeling, we dissect cellular RNA dynamics for Arabidopsis FLOWERING LOCUS C (FLC). FLC expression quantitatively determines flowering time and is regulated by antisense (COOLAIR) transcription. In cells without observable COOLAIR expression, we quantify FLC transcription initiation, elongation, intron processing, and lariat degradation, as well as mRNA release from the locus and degradation. In these heterogeneously sized cells, FLC mRNA number increases linearly with cell size, resulting in a large cell-to-cell variability in transcript level. This variation is accounted for by cell-sizedependent, Poissonian FLC mRNA production, but not by large transcriptional bursts. In COOLAIRexpressing cells, however, antisense transcription increases with cell size and contributes to FLC transcription decreasing with cell size. Our analysis therefore reveals an unexpected role for antisense transcription in modulating the scaling of transcription with cell size.},
  language  = {en}
}
@phdthesis{Janowski2017,
  author    = {Janowski, Marcin Andrzej},
  title     = {Investigating role of the essential GTPase - AtRsgA in the assembly of the small ribosomal subunit in Arabidopsis thaliana chloroplast},
  school      = {Universit{\"a}t Potsdam},
  pages     = {114},
  year      = {2017},
  language  = {en}
}
@phdthesis{Janowski2017,
  author    = {Janowski, Marcin Andrzej},
  title     = {Investigating role of the essential GTPase - AtRsgA in the assembly of the small ribosomal subunit in Arabidopsis thaliana chloroplast},
  school      = {Universit{\"a}t Potsdam},
  pages     = {X, 114},
  year      = {2017},
  abstract  = {Plastid protein biosynthesis occurs on bacterial-type 70S ribosomes consisting of a large (50S) and a small (30S) subunit. However, since many steps of ribosome biogenesis are not thermodynamically favorable at biological conditions, it requires many assembly factors. One group of assembly factors, circularly permuted GTPases, was implicated in 30S subunit maturation in E. coli, by a protein RsgA. RsgA orthologues are present in bacteria and plastid-containing species and in silico analysis revealed presence of a RsgA-like protein in Arabidopsis thaliana. To functionally characterize the Arabidopsis orthologue, two AtRsgA T-DNA insertion lines were analyzed in this study. The exon line (rsgA-e) led to embryo lethality, while the intron line (rsgA-i) caused severe dwarf, pale green phenotype. Further investigation of rsgA-i mutant line revealed defects in chloroplast biogenesis which led to increased number of chloroplasts, decreased chloroplast size, decreased air space between mesophyll cells and smaller shoot apical meristems, which showed unusual proplastid accumulation. Moreover, rsgA-i plants showed reduction in chlorophyll A and B content, decreased electron transport rate and photosynthetic efficiency. Further analyses revealed that the protein is involved in chloroplast 30S subunit maturation. Interestingly, we observed that while chloroplast-targeted and chloroplast-encoded proteins are generally downregulated in the mutant, a contrasting upregulation of the corresponding transcripts is observed, indicating an elaborate compensatory mechanism. To conclude, the study presented here reveals a ribosome assembly factor and a compensatory mechanism activated during impaired chloroplast function.},
  language  = {en}
}
@article{KangLimOhetal.2017,
  author    = {Kang, Mi-Sun and Lim, Hae-Soon and Oh, Jong-Suk and Lim, You-jin and Wuertz-Kozak, Karin and Harro, Janette M. and Shirtliff, Mark E. and Achermann, Yvonne},
  title     = {Antimicrobial activity of Lactobacillus salivarius and Lactobacillus fermentum against Staphylococcus aureus},
  series = {Pathogens and disease / Federation of European Microbiology Societies},
  volume    = {75},
  journal   = {Pathogens and disease / Federation of European Microbiology Societies},
  number    = {2},
  publisher = {Oxford Univ. Press},
  address   = {Oxford},
  issn      = {2049-632X},
  doi       = {10.1093/femspd/ftx009},
  pages     = {10},
  year      = {2017},
  abstract  = {The increasing prevalence of methicillin-resistant Staphylococcus aureus has become a major public health threat. While lactobacilli were recently found useful in combating various pathogens, limited data exist on their therapeutic potential for S. aureus infections. The aim of this study was to determine whether Lactobacillus salivarius was able to produce bactericidal activities against S. aureus and to determine whether the inhibition was due to a generalized reduction in pH or due to secreted Lactobacillus product(s). We found an 8.6-log10 reduction of planktonic and a 6.3-log10 reduction of biofilm S. aureus. In contrast, the previously described anti-staphylococcal effects of L. fermentum only caused a 4.0-log10 reduction in planktonic S. aureus cells, with no effect on biofilm S. aureus cells. Killing of S. aureus was partially pH dependent, but independent of nutrient depletion. Cell-free supernatant that was pH neutralized and heat inactivated or proteinase K treated had significantly reduced killing of L. salivarius than with pH-neutralized supernatant alone. Proteomic analysis of the L. salivarius secretome identified a total of five secreted proteins including a LysM-containing peptidoglycan binding protein and a protein peptidase M23B. These proteins may represent potential novel anti-staphylococcal agents that could be effective against S. aureus biofilms.},
  language  = {en}
}
@article{KehlmaierBarlowHastingsetal.2017,
  author    = {Kehlmaier, Christian and Barlow, Axel and Hastings, Alexander K. and Vamberger, Melita and Paijmans, Johanna L. A. and Steadman, David W. and Albury, Nancy A. and Franz, Richard and Hofreiter, Michael and Fritz, Uwe},
  title     = {Tropical ancient DNA reveals relationships of the extinct bahamian giant tortoise Chelonoidis alburyorum},
  series = {Proceedings of the Royal Society of London : Series B, Biological sciences},
  volume    = {284},
  journal   = {Proceedings of the Royal Society of London : Series B, Biological sciences},
  publisher = {The Royal Society},
  address   = {London},
  issn      = {0962-8452},
  doi       = {10.1098/rspb.2016.2235},
  pages     = {8},
  year      = {2017},
  abstract  = {Ancient DNA of extinct species from the Pleistocene and Holocene has provided valuable evolutionary insights. However, these are largely restricted to mammals and high latitudes because DNA preservation in warm climates is typically poor. In the tropics and subtropics, non-avian reptiles constitute a significant part of the fauna and little is known about the genetics of the many extinct reptiles from tropical islands. We have reconstructed the near-complete mitochondrial genome of an extinct giant tortoise from the Bahamas (Chelonoidis alburyorum) using an approximately 1000-year-old humerus from a water-filled sinkhole (blue hole) on Great Abaco Island. Phylogenetic and molecular clock analyses place this extinct species as closely related to Galapagos (C. niger complex) and Chaco tortoises (C. chilensis), and provide evidence for repeated overseas dispersal in this tortoise group. The ancestors of extant Chelonoidis species arrived in South America from Africa only after the opening of the Atlantic Ocean and dispersed from there to the Caribbean and the Galapagos Islands. Our results also suggest that the anoxic, thermally buffered environment of blue holes may enhance DNA preservation, and thus are opening a window for better understanding evolution and population history of extinct tropical species, which would likely still exist without human impact.},
  language  = {en}
}
@phdthesis{Kersting2017,
  author    = {Kersting, Sebastian},
  title     = {Isothermal nucleic acid amplification for the detection of infectious pathogens},
  pages     = {215},
  year      = {2017},
  language  = {en}
}
@misc{KleineVehnSauer2017,
  author    = {Kleine-Vehn, J{\"u}rgen and Sauer, Michael},
  title     = {Preface},
  series = {Plant Hormones: Methods and Protocols},
  volume    = {1497},
  journal   = {Plant Hormones: Methods and Protocols},
  editor    = {Kleine-Vehn, J{\"u}rgen and Sauer, Michael},
  edition   = {3},
  publisher = {Springer},
  address   = {New York},
  isbn      = {978-1-4939-6469-7},
  issn      = {1064-3745},
  doi       = {10.1007/978-1-4939-6469-7},
  pages     = {V -- V},
  year      = {2017},
  language  = {en}
}
@article{KloseRolkeBaumann2017,
  author    = {Klose, Sascha Peter and Rolke, Daniel and Baumann, Otto},
  title     = {Morphogenesis of honeybee hypopharyngeal gland during pupal development},
  series = {Frontiers in zoology},
  volume    = {14},
  journal   = {Frontiers in zoology},
  publisher = {BioMed Central},
  address   = {London},
  issn      = {1742-9994},
  doi       = {10.1186/s12983-017-0207-z},
  year      = {2017},
  abstract  = {Background The hypopharyngeal gland of worker bees contributes to the production of the royal jelly fed to queens and larvae. The gland consists of thousands of two-cell units that are composed of a secretory cell and a duct cell and that are arranged in sets of about 12 around a long collecting duct. Results By fluorescent staining, we have examined the morphogenesis of the hypopharyngeal gland during pupal life, from a saccule lined by a pseudostratified epithelium to the elaborate organ of adult worker bees. The hypopharyngeal gland develops as follows. (1) Cell proliferation occurs during the first day of pupal life in the hypopharyngeal gland primordium. (2) Subsequently, the epithelium becomes organized into rosette-like units of three cells. Two of these will become the secretory cell and the duct cell of the adult secretory units; the third cell contributes only temporarily to the development of the secretory units and is eliminated by apoptosis in the second half of pupal life. (3) The three-cell units of flask-shaped cells undergo complex changes in cell morphology. Thus, by mid-pupal stage, the gland is structurally similar to the adult hypopharyngeal gland. (4) Concomitantly, the prospective secretory cell attains its characteristic subcellular organization by the invagination of a small patch of apical membrane domain, its extension to a tube of about 100 μm in length (termed a canaliculus), and the expansion of the tube to a diameter of about 3 μm. (6) Finally, the canaliculus-associated F-actin system becomes reorganized into rings of bundled actin filaments that are positioned at regular distances along the membrane tube. Conclusions The morphogenesis of the secretory units in the hypopharyngeal gland of the worker bee seems to be based on a developmental program that is conserved, with slight modification, among insects for the production of dermal glands. Elaboration of the secretory cell as a unicellular seamless epithelial tube occurs by invagination of the apical membrane, its extension likely by targeted exocytosis and its expansion, and finally the reorganisation of the membrane-associated F-actin system. Our work is fundamental for future studies of environmental effects on hypopharyngeal gland morphology and development.},
  language  = {en}
}
@phdthesis{Knecht2017,
  author    = {Knecht, Volker},
  title     = {Modeling Biomolecular Association},
  school      = {Universit{\"a}t Potsdam},
  pages     = {297},
  year      = {2017},
  language  = {en}
}
@article{KocJanuchtaHoefflerThomaetal.2017,
  author    = {Koc-Januchta, Marta and H{\"o}ffler, Tim and Thoma, Gun-Brit and Prechtl, Helmut and Leutner, Detlev},
  title     = {Visualizers versus verbalizers},
  series = {Computers in human behavior},
  volume    = {68},
  journal   = {Computers in human behavior},
  publisher = {Elsevier},
  address   = {Oxford},
  issn      = {0747-5632},
  doi       = {10.1016/j.chb.2016.11.028},
  pages     = {170 -- 179},
  year      = {2017},
  abstract  = {This study was conducted in order to examine the differences between visualizers and verbalizers in the way they gaze at pictures and texts while learning. Using a collection of questionnaires, college students were classified according to their visual or verbal cognitive style and were asked to learn about two different, in terms of subject and type of knowledge, topics by means of text-picture combinations. Eye-tracking was used to investigate their gaze behavior. The results show that visualizers spent significantly more time inspecting pictures than verbalizers, while verbalizers spent more time inspecting texts. Results also suggest that both visualizers' and verbalizers' way of learning is active but mostly within areas providing the source of information in line with their cognitive style (pictures or text). Verbalizers tended to enter non-informative, irrelevant areas of pictures sooner than visualizers. The comparison of learning outcomes showed that the group of visualizers achieved better results than the group of verbalizers on a comprehension test.},
  language  = {en}
}
@misc{KocyanWilandSzymanska2017,
  author    = {Kocyan, Alexander and Wiland-Szymanska, Justyna},
  title     = {A new name and a new combination for Friedmannia nom. illeg. (Hypoxidaceae)},
  series = {Phytotaxa : a rapid international journal for accelerating the publication of botanical taxonomy},
  volume    = {291},
  journal   = {Phytotaxa : a rapid international journal for accelerating the publication of botanical taxonomy},
  number    = {3},
  publisher = {Magnolia Press},
  address   = {Auckland},
  issn      = {1179-3155},
  doi       = {10.11646/phytotaxa.291.3.10},
  pages     = {239 -- 239},
  year      = {2017},
  abstract  = {Recently, Kocyan \& Wiland-Szymańska (2016) have published a thorough research article on one of the outstanding members of the family Hypoxidaceae on the Seychelles, which resulted in the raise of a new genus (Friedmannia Kocyan \& Wiland-Szymańska 2016: 60) to accommodate the former Curculigo seychellensis Bojer ex Baker (1877: 368). However, it has turned out that the name Friedmannia Chantanachat \& Bold (1962: 45) already exists in literature for a green alga, which renders the new hypoxid genus illegitimate (Melbourne Code; McNeill et al. 2012). Therefore, we assign a new generic epithet to Curculigo seychellensis.},
  language  = {en}
}
@article{KolkNaafWulf2017,
  author    = {Kolk, Jens and Naaf, Tobias and Wulf, Monika},
  title     = {Paying the colonization credit},
  series = {Biodiversity and conservation},
  volume    = {26},
  journal   = {Biodiversity and conservation},
  publisher = {Springer},
  address   = {Dordrecht},
  issn      = {0960-3115},
  doi       = {10.1007/s10531-016-1271-y},
  pages     = {735 -- 755},
  year      = {2017},
  abstract  = {Massive historical land cover changes in the Central European lowlands have resulted in a forest distribution that now comprises small remnants of ancient forests and more recently established post-agricultural forests. Here, land-use history is considered a key driver of recent herb-layer community changes, where an extinction debt in ancient forest remnants and/or a colonization credit in post-agricultural forests are being paid over time. On a regional scale, these payments should in theory lead toward a convergence in species richness between ancient and post-agricultural forests over time. In this study, we tested this assumption with a resurvey of 117 semi-permanent plots in the well-studied deciduous forests of the Prignitz region (Brandenburg, NE Germany), where we knew that the plant communities of post-agricultural stands exhibit a colonization credit while the extinction debt in ancient stands has largely been paid. We compared changes in the species richness of all herb layer species, forest specialists and ancient forest indicator species between ancient and post-agricultural stands with linear mixed effect models and determined the influence of patch connectivity on the magnitude of species richness changes. Species richness increased overall, but the richness of forest specialists increased significantly more in post-agricultural stands and was positively influenced by higher patch connectivity, indicating a convergence in species richness between the ancient and postagricultural stands. Furthermore, the richness of ancient forest indicator species only increased significantly in post-agricultural stands. For the first time, we were able to verify a gradual payment of the colonization credit in post-agricultural forest stands using a comparison of actual changes in temporal species richness.},
  language  = {en}
}
@article{KoussoroplisSchwarzenbergerWacker2017,
  author    = {Koussoroplis, Apostolos-Manuel and Schwarzenberger, Anke and Wacker, Alexander},
  title     = {Diet quality determines lipase gene expression and lipase/esterase activity in Daphnia pulex},
  series = {Biology open : BiO},
  volume    = {6},
  journal   = {Biology open : BiO},
  publisher = {The company of Biologists},
  address   = {Cambridge},
  doi       = {10.1242/bio.022046},
  pages     = {210 -- 216},
  year      = {2017},
  abstract  = {We studied the short- (12 h) and long-term (144 h) response of Daphnia pulex lipases to quality shifts in diets consisting of different mixtures of the green alga Scenedesmus with the cyanobacterium Synechococcus, two species with contrasting lipid compositions. The lipase/esterase activity in both the gut and the body tissues had fast responses to the diet shift and increased with higher dietary contributions of Synechococcus. When screening the Daphnia genome for TAG lipases, we discovered a large gene-family expansion of these enzymes. We used a subset of eight genes for mRNA expression analyses and distinguished between influences of time and diet on the observed gene expression patterns. We identified five diet-responsive lipases of which three showed a sophisticated short- and long-term pattern of expression in response to small changes in food-quality. Furthermore, the gene expression of one of the lipases was strongly correlated to lipase/esterase activity in the gut suggesting its potentially major role in digestion. These findings demonstrate that the lipid-related enzymatic machinery of D. pulex is finely tuned to diet and might constitute an important mechanism of physiological adaptation in nutritionally complex environments.},
  language  = {en}
}
@misc{KozielHermanussenGomulaetal.2017,
  author    = {Koziel, Slawomir and Hermanussen, Michael and Gomula, Alexandra and Swanson, James and Kaczmarek, Maria and El-Shabrawi, Mortada and Elhusseini, Mona and Satake, Takashi and Martinovic Klaric, Irena and Scheffler, Christiane and Morkuniene, Ruta and Godina, Elena and Sasa, Missoni and Tutkuviene, Janina and Siniarska, Anna and Nieczuja-Dwojacka, Joanna and Nunez, Javier and Groth, Detlef and Barbieri, Davide},
  title     = {Adolescence - a Transition to Adulthood Proceedings of the 24th Aschauer Soiree, held at Jurata, Poland, November 5th 2016},
  series = {Pediatric Endocrinology Reviews},
  volume    = {14},
  journal   = {Pediatric Endocrinology Reviews},
  number    = {3},
  publisher = {Medical Media},
  address   = {Netanya},
  issn      = {1565-4753},
  pages     = {326 -- 334},
  year      = {2017},
  abstract  = {Eighteen scientists met at Jurata, Poland, to discuss various aspects of the transition from adolescence to adulthood. This transition is a delicate period facing complex interactions between the adolescents and the social group they belong to. Social identity, group identification and identity signalling, but also stress affecting basal salivary cortisol rhythms, hypertension, inappropriate nutrition causing latent and manifest obesity, moreover, in developing and under-developed countries, parasitosis causing anaemia thereby impairing growth and development, are issues to be dealt with during this period of the human development. In addition, some new aspects of the association between weight, height and head circumference in the newborns were discussed, as well as intrauterine head growth and head circumference as health risk indicators.},
  language  = {en}
}
@misc{KramerLenhard2017,
  author    = {Kramer, Elena M. and Lenhard, Michael},
  title     = {Shape and form in plant development},
  series = {Seminars in cell \& developmental biology},
  volume    = {79},
  journal   = {Seminars in cell \& developmental biology},
  publisher = {Elsevier},
  address   = {London},
  issn      = {1084-9521},
  doi       = {10.1016/j.semcdb.2017.11.004},
  pages     = {1 -- 2},
  year      = {2017},
  language  = {en}
}
@phdthesis{Kruse2017,
  author    = {Kruse, Stefan},
  title     = {Larix treeline dynamics in northern Siberia inferred from population genetics and individual-based modelling},
  school      = {Universit{\"a}t Potsdam},
  pages     = {181},
  year      = {2017},
  language  = {en}
}
@phdthesis{Kubsch2017,
  author    = {Kubsch, Bastian},
  title     = {Phase-specific fusion between biomembranes using SNARE mimetics},
  school      = {Universit{\"a}t Potsdam},
  pages     = {95},
  year      = {2017},
  language  = {en}
}
@phdthesis{Lachmann2017,
  author    = {Lachmann, Sabrina C.},
  title     = {Ecophysiology matters: Inorganic carbon acquisition in green microalgae related to different nutrient conditions},
  school      = {Universit{\"a}t Potsdam},
  pages     = {178},
  year      = {2017},
  language  = {en}
}
@article{LahLoeberHsiangetal.2017,
  author    = {Lah, Ljerka and L{\"o}ber, Ulrike and Hsiang, Tom and Hartmann, Stefanie},
  title     = {A genomic comparison of putative pathogenicity-related gene families in five members of the Ophiostomatales with different lifestyles},
  series = {Fungal biology},
  volume    = {121},
  journal   = {Fungal biology},
  publisher = {Elsevier},
  address   = {Oxford},
  issn      = {1878-6146},
  doi       = {10.1016/j.funbio.2016.12.002},
  pages     = {234 -- 252},
  year      = {2017},
  abstract  = {Ophiostomatoid fungi are vectored by their bark-beetle associates and colonize different host tree species. To survive and proliferate in the host, they have evolved mechanisms for detoxification and elimination of host defence compounds, efficient nutrient sequestration, and, in pathogenic species, virulence towards plants. Here, we assembled a draft genome of the spruce pathogen Ophiostoma bicolor. For our comparative and phylogenetic analyses, we mined the genomes of closely related species (Ophiostoma piceae, Ophiostoma ulmi, Ophiostoma novo-ulmi, and Grosmannia clavigera). Our aim was to acquire a genomic and evolutionary perspective of gene families important in host colonization. Genome comparisons showed that both the nuclear and mitochondrial genomes in our assembly were largely complete. Our O. bicolor 25.3 Mbp draft genome had 10 018 predicted genes, 6041 proteins with gene ontology (GO) annotation, 269 carbohydrate-active enzymes (CAZymes), 559 peptidases and inhibitors, and 1373 genes likely involved in pathogen-host interactions. Phylogenetic analyses of selected protein families revealed core sets of cytochrome P450 genes, ABC transporters and backbone genes involved in secondary metabolite (SM) biosynthesis (polyketide synthases (PKS) and non-ribosomal synthases), and species-specific gene losses and duplications. Phylogenetic analyses of protein families of interest provided insight into evolutionary adaptations to host biochemistry in ophiostomatoid fungi.},
  language  = {en}
}
@misc{LauxDocoslisWengeretal.2017,
  author    = {Laux, Eva-Maria and Docoslis, A. and Wenger, C. and Bier, Frank Fabian and H{\"o}lzel, Ralph},
  title     = {Combination of dielectrophoresis and SERS for bacteria detection and characterization},
  series = {European biophysics journal : with biophysics letters ; an international journal of biophysics},
  volume    = {46},
  journal   = {European biophysics journal : with biophysics letters ; an international journal of biophysics},
  publisher = {Springer},
  address   = {New York},
  issn      = {0175-7571},
  pages     = {S331 -- S331},
  year      = {2017},
  language  = {en}
}
@article{LecourieuxKappelPierietal.2017,
  author    = {Lecourieux, Fatma and Kappel, Christian and Pieri, Philippe and Charon, Justine and Pillet, Jeremy and Hilbert, Ghislaine and Renaud, Christel and Gomes, Eric and Delrot, Serge and Lecourieux, David},
  title     = {Dissecting the Biochemical and Transcriptomic Effects of a Locally Applied Heat Treatment on Developing Cabernet Sauvignon Grape Berries},
  series = {Frontiers in plant science},
  volume    = {8},
  journal   = {Frontiers in plant science},
  publisher = {Frontiers Research Foundation},
  address   = {Lausanne},
  issn      = {1664-462X},
  doi       = {10.3389/fpls.2017.00053},
  pages     = {23},
  year      = {2017},
  abstract  = {Reproductive development of grapevine and berry composition are both strongly influenced by temperature. To date, the molecular mechanisms involved in grapevine berries response to high temperatures are poorly understood. Unlike recent data that addressed the effects on berry development of elevated temperatures applied at the whole plant level, the present work particularly focuses on the fruit responses triggered by direct exposure to heat treatment (HT). In the context of climate change, this work focusing on temperature effect at the microclimate level is of particular interest as it can help to better understand the consequences of leaf removal (a common viticultural practice) on berry development. HT (+8 degrees C) was locally applied to clusters from Cabernet Sauvignon fruiting cuttings at three different developmental stages (middle green, veraison and middle ripening). Samples were collected 1, 7, and 14 days after treatment and used for metabolic and transcriptomic analyses. The results showed dramatic and specific biochemical and transcriptomic changes in heat exposed berries, depending on the developmental stage and the stress duration. When applied at the herbaceous stage, HT delayed the onset of veraison. Heating also strongly altered the berry concentration of amino acids and organic acids (e.g., phenylalanine, raminobutyric acid and malate) and decreased the anthocyanin content at maturity. These physiological alterations could be partly explained by the deep remodeling of transcriptome in heated berries. More than 7000 genes were deregulated in at least one of the nine experimental conditions. The most affected processes belong to the categories "stress responses," protein metabolism" and "secondary metabolism," highlighting the intrinsic capacity of grape berries to perceive HT and to build adaptive responses. Additionally, important changes in processes related to "transport," "hormone" and "cell wall" might contribute to the postponing of veraison. Finally, opposite effects depending on heating duration were observed for genes encoding enzymes of the general phenylpropanoid pathway, suggesting that the HI induced decrease in anthocyanin content may result from a combination of transcript abundance and product degradation.},
  language  = {en}
}
@article{LehmannFlorisWoiteketal.2017,
  author    = {Lehmann, Andreas and Floris, Jo{\"e}l and Woitek, Ulrich and Ruehli, Frank J. and Staub, Kaspar},
  title     = {Temporal trends, regional variation and socio-economic differences in height, BMI and body proportions among German conscripts, 1956-2010},
  series = {Public Health Nutrition},
  volume    = {20},
  journal   = {Public Health Nutrition},
  number    = {3},
  publisher = {Cambridge Univ. Press},
  address   = {Cambridge},
  issn      = {1368-9800},
  doi       = {10.1017/S1368980016002408},
  pages     = {391 -- 403},
  year      = {2017},
  abstract  = {Objective: We analyse temporal trends and regional variation among the most recent available anthropometric data from German conscription in the years 2008-2010 and their historical contextualization since 1956. Design/setting/subjects: The overall sample included German conscripts (N 13 857 313) from 1956 to 2010. Results: German conscripts changed from growing in height to growing in breadth. Over the analysed 54 years, average height of 19-year-old conscripts increased by 6.5 cm from 173.5 cm in 1956 (birth year 1937) to 180.0 cm in 2010 (birth year 1991). This increase plateaued since the 1990s (1970s birth years). The increase in average weight, however, did not lessen during the last two decades but increased in two steps: at the end of the 1980s and after 1999. The weight and BMI distributions became increasingly right-skewed, the prevalence of overweight and obesity increased from 11.6 \% and 2.1 \% in 1984 to 19.9 \% and 8.5 \% in 2010, respectively. The north-south gradient in height (north = taller) persisted during our observations. Height and weight of conscripts from East Germany matched the German average between the early 1990s and 2009. Between the 1980s and the early 1990s, the average chest circumference increased, the average difference between chest circumference when inhaling and exhaling decreased, as did leg length relative to trunk length. Conclusions: Measuring anthropometric data for military conscripts yielded year-by-year monitoring of the health status of young men at a proscribed age. Such findings contribute to a more precise identification of groups at risk and thus help with further studies and to target interventions.},
  language  = {en}
}
@misc{LeimkuehlerBuehningBeilschmidt2017,
  author    = {Leimk{\"u}hler, Silke and B{\"u}hning, Martin and Beilschmidt, Lena},
  title     = {Shared sulfur mobilization routes for tRNA thiolation and molybdenum cofactor biosynthesis in prokaryotes and eukaryotes},
  series = {Biomolecules},
  volume    = {7},
  journal   = {Biomolecules},
  number    = {1},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2218-273X},
  doi       = {10.3390/biom7010005},
  pages     = {20},
  year      = {2017},
  abstract  = {Modifications of transfer RNA (tRNA) have been shown to play critical roles in the biogenesis, metabolism, structural stability and function of RNA molecules, and the specific modifications of nucleobases with sulfur atoms in tRNA are present in pro- and eukaryotes. Here, especially the thiomodifications xm(5)s(2)U at the wobble position 34 in tRNAs for Lys, Gln and Glu, were suggested to have an important role during the translation process by ensuring accurate deciphering of the genetic code and by stabilization of the tRNA structure. The trafficking and delivery of sulfur nucleosides is a complex process carried out by sulfur relay systems involving numerous proteins, which not only deliver sulfur to the specific tRNAs but also to other sulfur-containing molecules including iron-sulfur clusters, thiamin, biotin, lipoic acid and molybdopterin (MPT). Among the biosynthesis of these sulfur-containing molecules, the biosynthesis of the molybdenum cofactor (Moco) and the synthesis of thio-modified tRNAs in particular show a surprising link by sharing protein components for sulfur mobilization in pro- and eukaryotes.},
  language  = {en}
}
@article{LeimkuehlerLemaireIobbiNivol2017,
  author    = {Leimk{\"u}hler, Silke and Lemaire, Olivier N. and Iobbi-Nivol, Chantal},
  title     = {Bacterial Molybdoenzymes},
  series = {Molybdenum and tungsten enzymes : biochemistry},
  volume    = {5},
  journal   = {Molybdenum and tungsten enzymes : biochemistry},
  publisher = {Royal Society of Chemistry},
  address   = {Cambridge},
  isbn      = {978-1-78262-391-5},
  doi       = {10.1039/9781782623915-00117},
  pages     = {117 -- 142},
  year      = {2017},
  abstract  = {The biogenesis of molybdoenzymes is a cytoplasmic event requiring both the folded apoenzymes and the matured molybdenum cofactor. The structure and the complexity of the molybdenum cofactor varies in each molybdoenzyme family and consequently different accessory proteins are required for the maturation of the respective enzymes. Thus, for enzymes of both the DMSO reductase and xanthine oxidase families, specific chaperones exist which are dedicated to increase the stability and the folding of specific members of each family. In this review, we describe the role of these chaperones for molybdoenzyme maturation. We present a model which describes step by step the mechanism of the maturation of representative molybdoenzymes from each family.},
  language  = {en}
}
@article{LeimkuehlerMendel2017,
  author    = {Leimk{\"u}hler, Silke and Mendel, Ralf-Rainer},
  title     = {Molybdenum Cofactor Biosynthesis},
  series = {Molybdenum and tungsten enzymes: biochemistry},
  volume    = {5},
  journal   = {Molybdenum and tungsten enzymes: biochemistry},
  publisher = {Royal Society of Chemistry},
  address   = {Cambridge},
  isbn      = {978-1-78262-391-5},
  doi       = {10.1039/9781782623915},
  pages     = {100 -- 116},
  year      = {2017},
  abstract  = {The biosynthesis of the molybdenum cofactor (Moco) is highly conserved among all kingdoms of life. In all molybdoenzymes with the exception of nitrogenase, the molybdenum atom is coordinated to a dithiolene group present in the pterin-based 6-alkyl side chain of molybdopterin (MPT). In general, the biosynthesis of Moco can be divided into three steps in eukaryotes, and four steps in bacteria and archaea: (i) the starting point is the formation of the cyclic pyranopterin monophosphate (cPMP) from 5′GTP, (ii) in the second step the two sulfur molecules are inserted into cPMP leading to the formation of MPT, (iii) in the third step the molybdenum atom is inserted into molybdopterin to form Moco and (iv) additional modification of Moco occurs in bacteria and archaea with the attachment of a nucleotide (CMP or GMP) to the phosphate group of MPT, forming the dinucleotide variants of Moco. This review will focus on the biosynthesis of Moco in bacteria, humans and plants.},
  language  = {en}
}
@article{LiXuWangetal.2017,
  author    = {Li, Zhengdong and Xu, Xun and Wang, Weiwei and Kratz, Karl and Sun, Xianlei and Zou, Jie and Deng, Zijun and Jung, Friedrich Wilhelm and Gossen, Manfred and Ma, Nan and Lendlein, Andreas},
  title     = {Modulation of the mesenchymal stem cell migration capacity via preconditioning with topographic microstructure},
  series = {Clinical hemorheology and microcirculation : blood flow and vessels},
  volume    = {67},
  journal   = {Clinical hemorheology and microcirculation : blood flow and vessels},
  publisher = {IOS Press},
  address   = {Amsterdam},
  issn      = {1386-0291},
  doi       = {10.3233/CH-179208},
  pages     = {267 -- 278},
  year      = {2017},
  abstract  = {Controlling mesenchymal stem cells (MSCs) behavior is necessary to fully exploit their therapeutic potential. Various approaches are employed to effectively influence the migration capacity of MSCs. Here, topographic microstructures with different microscale roughness were created on polystyrene (PS) culture vessel surfaces as a feasible physical preconditioning strategy to modulate MSC migration. By analyzing trajectories of cells migrating after reseeding, we demonstrated that the mobilization velocity of human adipose derived mesenchymal stem cells (hADSCs) could be promoted by and persisted after brief preconditioning with the appropriate microtopography. Moreover, the elevated activation levels of focal adhesion kinase (FAK) and mitogen-activated protein kinase (MAPK) in hADSCs were also observed during and after the preconditioning process. These findings underline the potential enhancement of in vivo therapeutic efficacy in regenerative medicine via transplantation of topographic microstructure preconditioned stem cells.},
  language  = {en}
}
@phdthesis{Loiacono2017,
  author    = {Loiacono, Filomena Vanessa},
  title     = {Transfer of chloroplast RNA editing events between species},
  school      = {Universit{\"a}t Potsdam},
  pages     = {155},
  year      = {2017},
  language  = {en}
}