@phdthesis{Nacak2021,
  author    = {Nacak, Selma},
  title     = {Synthesis and Characterization of Upconversion Nanaparticles for Applications in Life Sciences},
  school      = {Universit{\"a}t Potsdam},
  year      = {2021},
  language  = {en}
}
@article{NeffeIzraylitHommesSchattmannetal.2021,
  author    = {Neffe, Axel T. and Izraylit, Victor and Hommes-Schattmann, Paul J. and Lendlein, Andreas},
  title     = {Soft, formstable (Co)polyester blend elastomers},
  series = {Nanomaterials : open access journal},
  volume    = {11},
  journal   = {Nanomaterials : open access journal},
  number    = {6},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2079-4991},
  doi       = {10.3390/nano11061472},
  pages     = {18},
  year      = {2021},
  abstract  = {High crystallization rate and thermomechanical stability make polylactide stereocomplexes effective nanosized physical netpoints. Here, we address the need for soft, form-stable degradable elastomers for medical applications by designing such blends from (co)polyesters, whose mechanical properties are ruled by their nanodimensional architecture and which are applied as single components in implants. By careful controlling of the copolymer composition and sequence structure of poly[(L-lactide)-co-(epsilon-caprolactone)], it is possible to prepare hyperelastic polymer blends formed through stereocomplexation by adding poly(D-lactide) (PDLA). Low glass transition temperature T-g <= 0 degrees C of the mixed amorphous phase contributes to the low Young's modulus E. The formation of stereocomplexes is shown in DSC by melting transitions T-m > 190 degrees C and in WAXS by distinct scattering maxima at 2 theta = 12 degrees and 21 degrees. Tensile testing demonstrated that the blends are soft (E = 12-80 MPa) and show an excellent hyperelastic recovery R-rec = 66-85\% while having high elongation at break epsilon(b) up to >1000\%. These properties of the blends are attained only when the copolymer has 56-62 wt\% lactide content, a weight average molar mass >140 kg center dot mol(-1), and number average lactide sequence length >= 4.8, while the blend is formed with a content of 5-10 wt\% of PDLA. The devised strategy to identify a suitable copolymer for stereocomplexation and blend formation is transferable to further polymer systems and will support the development of thermoplastic elastomers suitable for medical applications.},
  language  = {en}
}
@article{BhuvaneshMachatschekLysyakovaetal.2019,
  author    = {Bhuvanesh, Thanga and Machatschek, Rainhard Gabriel and Lysyakova, Liudmila and Kratz, Karl and Schulz, Burkhard and Ma, Nan and Lendlein, Andreas},
  title     = {Collagen type-IV Langmuir and Langmuir-Schafer layers as model biointerfaces to direct stem cell adhesion},
  series = {Biomedical materials : materials for tissue engineering and regenerative medicine},
  volume    = {14},
  journal   = {Biomedical materials : materials for tissue engineering and regenerative medicine},
  number    = {2},
  publisher = {Inst. of Physics Publ.},
  address   = {Bristol},
  issn      = {1748-6041},
  doi       = {10.1088/1748-605X/aaf464},
  pages     = {17},
  year      = {2019},
  abstract  = {In biomaterial development, the design of material surfaces that mimic the extra-cellular matrix (ECM) in order to achieve favorable cellular instruction is rather challenging. Collagen-type IV (Col-IV), the major scaffolding component of Basement Membranes (BM), a specialized ECM with multiple biological functions, has the propensity to form networks by self-assembly and supports adhesion of cells such as endothelial cells or stem cells. The preparation of biomimetic Col-IV network-like layers to direct cell responses is difficult. We hypothesize that the morphology of the layer, and especially the density of the available adhesion sites, regulates the cellular adhesion to the layer. The Langmuir monolayer technique allows for preparation of thin layers with precisely controlled packing density at the air-water (A-W) interface. Transferring these layers onto cell culture substrates using the Langmuir-Schafer (LS) technique should therefore provide a pathway for preparation of BM mimicking layers with controlled cell adherence properties. In situ characterization using ellipsometry and polarization modulation-infrared reflection absorption spectroscopy of Col-IV layer during compression at the A-W interface reveal that there is linear increase of surface molecule concentration with negligible orientational changes up to a surface pressure of 25 mN m(-1). Smooth and homogeneous Col-IV network-like layers are successfully transferred by LS method at 15 mN m(-1) onto poly(ethylene terephthalate) (PET), which is a common substrate for cell culture. In contrast, the organization of Col-IV on PET prepared by the traditionally employed solution deposition method results in rather inhomogeneous layers with the appearance of aggregates and multilayers. Progressive increase in the number of early adherent mesenchymal stem cells (MSCs) after 24 h by controlling the areal Col-IV density by LS transfer at 10, 15 and 20 mN m(-1) on PET is shown. The LS method offers the possibility to control protein characteristics on biomaterial surfaces such as molecular density and thereby, modulate cell responses.},
  language  = {en}
}
@article{ErlerRiebeBeitzetal.2020,
  author    = {Erler, Alexander and Riebe, Daniel and Beitz, Toralf and L{\"o}hmannsr{\"o}ben, Hans-Gerd and Grothusheitkamp, Daniela and Kunz, Thomas and Methner, Frank-J{\"u}rgen},
  title     = {Characterization of volatile metabolites formed by molds on barley by mass and ion mobility spectrometry},
  series = {Journal of mass spectrometr},
  volume    = {55},
  journal   = {Journal of mass spectrometr},
  number    = {5},
  publisher = {Wiley},
  address   = {Hoboken},
  issn      = {1076-5174},
  doi       = {10.1002/jms.4501},
  pages     = {1 -- 10},
  year      = {2020},
  abstract  = {The contamination of barley by molds on the field or in storage leads to the spoilage of grain and the production of mycotoxins, which causes major economic losses in malting facilities and breweries. Therefore, on-site detection of hidden fungus contaminations in grain storages based on the detection of volatile marker compounds is of high interest. In this work, the volatile metabolites of 10 different fungus species are identified by gas chromatography (GC) combined with two complementary mass spectrometric methods, namely, electron impact (EI) and chemical ionization at atmospheric pressure (APCI)-mass spectrometry (MS). The APCI source utilizes soft X-radiation, which enables the selective protonation of the volatile metabolites largely without side reactions. Nearly 80 volatile or semivolatile compounds from different substance classes, namely, alcohols, aldehydes, ketones, carboxylic acids, esters, substituted aromatic compounds, alkenes, terpenes, oxidized terpenes, sesquiterpenes, and oxidized sesquiterpenes, could be identified. The profiles of volatile and semivolatile metabolites of the different fungus species are characteristic of them and allow their safe differentiation. The application of the same GC parameters and APCI source allows a simple method transfer from MS to ion mobility spectrometry (IMS), which permits on-site analyses of grain stores. Characterization of IMS yields limits of detection very similar to those of APCI-MS. Accordingly, more than 90\% of the volatile metabolites found by APCI-MS were also detected in IMS. In addition to different fungus genera, different species of one fungus genus could also be differentiated by GC-IMS.},
  language  = {en}
}
@misc{EbelBald2020,
  author    = {Ebel, Kenny and Bald, Ilko},
  title     = {Length and Energy Dependence of Low-Energy Electron-Induced Strand Breaks in Poly(A) DNA},
  series = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  journal   = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  number    = {814},
  issn      = {1866-8372},
  doi       = {10.25932/publishup-44412},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-444125},
  pages     = {13},
  year      = {2020},
  abstract  = {The DNA in living cells can be effectively damaged by high-energy radiation, which can lead to cell death. Through the ionization of water molecules, highly reactive secondary species such as low-energy electrons (LEEs) with the most probable energy around 10 eV are generated, which are able to induce DNA strand breaks via dissociative electron attachment. Absolute DNA strand break cross sections of specific DNA sequences can be efficiently determined using DNA origami nanostructures as platforms exposing the target sequences towards LEEs. In this paper, we systematically study the effect of the oligonucleotide length on the strand break cross section at various irradiation energies. The present work focuses on poly-adenine sequences (d(A₄), d(A₈), d(A₁₂), d(A₁₆), and d(A₂₀)) irradiated with 5.0, 7.0, 8.4, and 10 eV electrons. Independent of the DNA length, the strand break cross section shows a maximum around 7.0 eV electron energy for all investigated oligonucleotides confirming that strand breakage occurs through the initial formation of negative ion resonances. When going from d(A₄) to d(A₁₆), the strand break cross section increases with oligonucleotide length, but only at 7.0 and 8.4 eV, i.e., close to the maximum of the negative ion resonance, the increase in the strand break cross section with the length is similar to the increase of an estimated geometrical cross section. For d(A₂₀), a markedly lower DNA strand break cross section is observed for all electron energies, which is tentatively ascribed to a conformational change of the dA₂₀ sequence. The results indicate that, although there is a general length dependence of strand break cross sections, individual nucleotides do not contribute independently of the absolute strand break cross section of the whole DNA strand. The absolute quantification of sequence specific strand breaks will help develop a more accurate molecular level understanding of radiation induced DNA damage, which can then be used for optimized risk estimates in cancer radiation therapy.},
  language  = {en}
}
@article{FudickarRoderListeketal.2021,
  author    = {Fudickar, Werner and Roder, Phillip and Listek, Martin and Hanack, Katja and Linker, Torsten},
  title     = {Pyridinium alkynylanthracenes as sensitizers for photodynamic therapy},
  series = {Photochemistry and photobiology},
  volume    = {98},
  journal   = {Photochemistry and photobiology},
  number    = {1},
  publisher = {Wiley},
  address   = {Hoboken},
  issn      = {0031-8655},
  doi       = {10.1111/php.13554},
  pages     = {193 -- 201},
  year      = {2021},
  abstract  = {Photodynamic therapy (PDT) is a mild but effective method to treat certain types of cancer upon irradiation with visible light. Here, three isomeric methylpyridinium alkynylanthracenes 1op were evaluated as sensitizers for PDT. Upon irradiation with blue or green light, all three compounds show the ability to initiate strand breaks of plasmid DNA. The mayor species responsible for cleavage is singlet oxygen (O-1(2)) as confirmed by scavenging reagents. Only isomers 1m and 1p can be incorporated into HeLa cells, whereas isomer 1o cannot permeate through the membrane. While isomer 1m targets the cell nucleus, isomer 1p assembles in the cellular cytoplasm and impacts the cellular integrity. This is in accordance with a moderate toxicity of 1p in the dark, whereas 1m exhibits no dark toxicity. Both isomers are suitable as PDT reagents, with a CC50 of 3 mu m and 75 nm, for 1p and 1m, respectively. Thus, derivative 1m, which can be easily synthesized, becomes an interesting candidate for cancer therapy.},
  language  = {en}
}
@misc{NiedlBeta2015,
  author    = {Niedl, Robert Raimund and Beta, Carsten},
  title     = {Hydrogel-driven paper-based microfluidics},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-81083},
  pages     = {2452 -- 2459},
  year      = {2015},
  abstract  = {Paper-based microfluidics provide an inexpensive, easy to use technology for point-of-care diagnostics in developing countries. Here, we combine paper-based microfluidic devices with responsive hydrogels to add an entire new class of functions to these versatile low-cost fluidic systems. The hydrogels serve as fluid reservoirs. In response to an external stimulus, e.g. an increase in temperature, the hydrogels collapse and release fluid into the structured paper substrate. In this way, chemicals that are either stored on the paper substrate or inside the hydrogel pads can be dissolved, premixed, and brought to reaction to fulfill specific analytic tasks. We demonstrate that multi-step sequences of chemical reactions can be implemented in a paper-based system and operated without the need for external precision pumps. We exemplify this technology by integrating an antibody-based E. coli test on a small and easy to use paper device.},
  language  = {en}
}
@article{NiedlBeta2015,
  author    = {Niedl, Robert Raimund and Beta, Carsten},
  title     = {Hydrogel-driven paper-based microfluidics},
  series = {LAB on a chip : miniaturisation for chemistry and biology},
  volume    = {11},
  journal   = {LAB on a chip : miniaturisation for chemistry and biology},
  number    = {15},
  publisher = {Royal Society of Chemistry},
  address   = {Cambridge},
  issn      = {1473-0197},
  doi       = {10.1039/c5lc00276a},
  pages     = {2452 -- 2459},
  year      = {2015},
  abstract  = {Paper-based microfluidics provide an inexpensive, easy to use technology for point-of-care diagnostics in developing countries. Here, we combine paper-based microfluidic devices with responsive hydrogels to add an entire new class of functions to these versatile low-cost fluidic systems. The hydrogels serve as fluid reservoirs. In response to an external stimulus, e.g. an increase in temperature, the hydrogels collapse and release fluid into the structured paper substrate. In this way, chemicals that are either stored on the paper substrate or inside the hydrogel pads can be dissolved, premixed, and brought to reaction to fulfill specific analytic tasks. We demonstrate that multi-step sequences of chemical reactions can be implemented in a paper-based system and operated without the need for external precision pumps. We exemplify this technology by integrating an antibody-based E. coli test on a small and easy to use paper device.},
  language  = {en}
}
@article{WangSperlingReifarthetal.2020,
  author    = {Wang, Xuepu and Sperling, Marcel and Reifarth, Martin and B{\"o}ker, Alexander},
  title     = {Shaping metallic nanolattices},
  series = {Small},
  volume    = {16},
  journal   = {Small},
  number    = {11},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1613-6810},
  doi       = {10.1002/smll.201906721},
  pages     = {1 -- 8},
  year      = {2020},
  abstract  = {A method for the fabrication of well-defined metallic nanostructures is presented here in a simple and straightforward fashion. As an alternative to lithographic techniques, this routine employs microcontact printing utilizing wrinkled stamps, which are prepared from polydimethylsiloxane (PDMS), and includes the formation of hydrophobic stripe patterns on a substrate via the transfer of oligomeric PDMS. Subsequent backfilling of the interspaces between these stripes with a hydroxyl-functional poly(2-vinyl pyridine) then provides the basic pattern for the deposition of citrate-stabilized gold nanoparticles promoted by electrostatic interaction. The resulting metallic nanostripes can be further customized by peeling off particles in a second microcontact printing step, which employs poly(ethylene imine) surface-decorated wrinkled stamps, to form nanolattices. Due to the independent adjustability of the period dimensions of the wrinkled stamps and stamp orientation with respect to the substrate, particle arrays on the (sub)micro-scale with various kinds of geometries are accessible in a straightforward fashion. This work provides an alternative, cost-effective, and scalable surface-patterning technique to fabricate nanolattice structures applicable to multiple types of functional nanoparticles. Being a top-down method, this process could be readily implemented into, e.g., the fabrication of optical and sensing devices on a large scale.},
  language  = {en}
}
@inproceedings{RamadanGuerreroNedielkovetal.2021,
  author    = {Ramadan, Shahenda and Guerrero, Paula and Nedielkov, Ruslan and Klishin, Nikolai and Dimova, Rumiana and Silva, Daniel V. and M{\"o}ller, Heiko},
  title     = {Building a mimetic system for unraveling protein-protein interactions on membranes},
  series = {European biophysics journal : with biophysics letters ; an international journal of biophysics},
  volume    = {50},
  booktitle = {European biophysics journal : with biophysics letters ; an international journal of biophysics},
  number    = {SUPPL 1},
  publisher = {Springer},
  address   = {Berlin ; Heidelberg ; New York},
  issn      = {0175-7571},
  doi       = {10.1007/s00249-021-01558-w},
  pages     = {S153 -- S153},
  year      = {2021},
  language  = {en}
}
@article{PilusoVukicevieNoecheletal.2018,
  author    = {Piluso, Susanna and Vukicevie, Radovan and N{\"o}chel, Ulrich and Braune, Steffen and Lendlein, Andreas and Neffe, Axel T.},
  title     = {Sequential alkyne-azide cycloadditions for functionalized gelatin hydrogel formation},
  series = {European polymer journal},
  volume    = {100},
  journal   = {European polymer journal},
  publisher = {Elsevier},
  address   = {Oxford},
  issn      = {0014-3057},
  doi       = {10.1016/j.eurpolymj.2018.01.017},
  pages     = {77 -- 85},
  year      = {2018},
  abstract  = {While click chemistry reactions for biopolymer network formation are attractive as the defined reactions may allow good control of the network formation and enable subsequent functionalization, tailoring of gelatin network properties over a wide range of mechanical properties has yet to be shown. Here, it is demonstrated that copper-catalyzed alkyne-azide cycloaddition of alkyne functionalized gelatin with diazides gave hydrogel networks with properties tailorable by the ratio of diazide to gelatin and diazide rigidity. 4,4′-diazido-2,2′-stilbenedisulfonic acid, which has been used as rigid crosslinker, yielded hydrogels with Young's moduli E of 50-390 kPa and swelling degrees Q of 150-250 vol.\%, while the more flexible 1,8-diazidooctane resulted in hydrogels with E = 125-280 kPa and Q = 225-470 vol.\%. Storage moduli could be varied by two orders of magnitude (G′ = 100-20,000 Pa). An indirect cytotoxicity test did not show cytotoxic properties. Even when employing 1:1 ratios of alkyne and azide moieties, the hydrogels were shown to contain both, unreacted alkyne groups on the gelatin backbone as well as dangling chains carrying azide groups as shown by reaction with functionalized fluorescein. The free groups, which can be tailored by the employed ratio of the reactants, are accessible for covalent attachment of drugs, as was demonstrated by functionalization with dexamethasone. The sequential network formation and functionalization with click chemistry allows access to multifunctional materials relevant for medical applications.},
  language  = {en}
}
@article{HeyneArltGessneretal.2020,
  author    = {Heyne, Benjamin and Arlt, Kristin and Geßner, Andr{\´e} and Richter, Alexander F. and D{\"o}blinger, Markus and Feldmann, Jochen and Taubert, Andreas and Wedel, Armin},
  title     = {Mixed Mercaptocarboxylic Acid Shells Provide Stable Dispersions of InPZnS/ZnSe/ZnS Multishell Quantum Dots in Aqueous Media},
  series = {Nanomaterials},
  volume    = {10},
  journal   = {Nanomaterials},
  number    = {9},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2079-4991},
  doi       = {10.3390/nano10091858},
  pages     = {24},
  year      = {2020},
  abstract  = {Highly luminescent indium phosphide zinc sulfide (InPZnS) quantum dots (QDs), with zinc selenide/zinc sulfide (ZnSe/ZnS) shells, were synthesized. The QDs were modified via a post-synthetic ligand exchange reaction with 3-mercaptopropionic acid (MPA) and 11-mercaptoundecanoic acid (MUA) in different MPA:MUA ratios, making this study the first investigation into the effects of mixed ligand shells on InPZnS QDs. Moreover, this article also describes an optimized method for the correlation of the QD size vs. optical absorption of the QDs. Upon ligand exchange, the QDs can be dispersed in water. Longer ligands (MUA) provide more stable dispersions than short-chain ligands. Thicker ZnSe/ZnS shells provide a better photoluminescence quantum yield (PLQY) and higher emission stability upon ligand exchange. Both the ligand exchange and the optical properties are highly reproducible between different QD batches. Before dialysis, QDs with a ZnS shell thickness of ~4.9 monolayers (ML), stabilized with a mixed MPA:MUA (mixing ratio of 1:10), showed the highest PLQY, at ~45\%. After dialysis, QDs with a ZnS shell thickness of ~4.9 ML, stabilized with a mixed MPA:MUA and a ratio of 1:10 and 1:100, showed the highest PLQYs, of ~41\%. The dispersions were stable up to 44 days at ambient conditions and in the dark. After 44 days, QDs with a ZnS shell thickness of ~4.9 ML, stabilized with only MUA, showed the highest PLQY, of ~34\%.},
  language  = {en}
}
@article{TaoLiuWuetal.2020,
  author    = {Tao, Lumi and Liu, Yuchuan and Wu, Dan and Wei, Qiao-Hua and Taubert, Andreas and Xie, Zailai},
  title     = {Luminescent Ionogels with Excellent Transparency, High Mechanical Strength, and High Conductivity},
  series = {Nanomaterials},
  volume    = {10},
  journal   = {Nanomaterials},
  number    = {12},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2079-4991},
  doi       = {10.3390/nano10122521},
  pages     = {11},
  year      = {2020},
  abstract  = {The paper describes a new kind of ionogel with both good mechanical strength and high conductivity synthesized by confining the ionic liquid (IL) 1-butyl-3-methylimidazolium bis(trifluoromethane sulfonyl)imide ([Bmim][NTf₂]) within an organic-inorganic hybrid host. The organic-inorganic host network was synthesized by the reaction of methyltrimethoxysilane (MTMS), tetraethoxysilane (TEOS), and methyl methacrylate (MMA) in the presence of a coupling agent, offering the good mechanical strength and rapid shape recovery of the final products. The silane coupling agent 3-methacryloxypropyltrimethoxysilane (KH-570) plays an important role in improving the mechanical strength of the inorganic-organic hybrid, because it covalently connected the organic component MMA and the inorganic component SiO₂. Both the thermal stability and mechanical strength of the ionogel significantly increased by the addition of IL. The immobilization of [Bmim][NTf₂] within the ionogel provided the final ionogel with an ionic conductivity as high as ca. 0.04 S cm⁻¹ at 50 °C. Moreover, the hybrid ionogel can be modified with organosilica-modified carbon dots within the network to yield a transparent and flexible ionogel with strong excitation-dependent emission between 400 and 800 nm. The approach is, therefore, a blueprint for the construction of next-generation multifunctional ionogels.},
  language  = {en}
}
@misc{ZehbeKolloscheLardongetal.2017,
  author    = {Zehbe, Kerstin and Kollosche, Matthias and Lardong, Sebastian and Kelling, Alexandra and Schilde, Uwe and Taubert, Andreas},
  title     = {Ionogels based on poly(methyl methacrylate) and metal-containing ionic liquids},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-400607},
  pages     = {16},
  year      = {2017},
  abstract  = {Ionogels (IGs) based on poly(methyl methacrylate) (PMMA) and the metal-containing ionic liquids (ILs) bis-1-butyl-3-methlimidazolium tetrachloridocuprate(II), tetrachloride cobaltate(II), and tetrachlorido manganate(II) have been synthesized and their mechanical and electrical properties have been correlated with their microstructure. Unlike many previous examples, the current IGs show a decreasing stability in stress-strain experiments on increasing IL fractions. The conductivities of the current IGs are lower than those observed in similar examples in the literature. Both effects are caused by a two-phase structure with micrometer-sized IL-rich domains homogeneously dispersed an IL-deficient continuous PMMA phase. This study demonstrates that the IL-polymer miscibility and the morphology of the IGs are key parameters to control the (macroscopic) properties of IGs.},
  language  = {en}
}
@article{KuntzeViljakkaTitovetal.2022,
  author    = {Kuntze, Kim and Viljakka, Jani and Titov, Evgenii and Ahmed, Zafar and Kalenius, Elina and Saalfrank, Peter and Priimagi, Arri},
  title     = {Towards low-energy-light-driven bistable photoswitches},
  series = {Photochemical \& photobiological sciences / European Society for Photobiology},
  volume    = {21},
  journal   = {Photochemical \& photobiological sciences / European Society for Photobiology},
  number    = {2},
  publisher = {Springer},
  address   = {Heidelberg},
  issn      = {1474-905X},
  doi       = {10.1007/s43630-021-00145-4},
  pages     = {159 -- 173},
  year      = {2022},
  abstract  = {Thermally stable photoswitches that are driven with low-energy light are rare, yet crucial for extending the applicability of photoresponsive molecules and materials towards, e.g., living systems. Combined ortho-fluorination and -amination couples high visible light absorptivity of o-aminoazobenzenes with the extraordinary bistability of o-fluoroazobenzenes. Herein, we report a library of easily accessible o-aminofluoroazobenzenes and establish structure-property relationships regarding spectral qualities, visible light isomerization efficiency and thermal stability of the cis-isomer with respect to the degree of o-substitution and choice of amino substituent. We rationalize the experimental results with quantum chemical calculations, revealing the nature of low-lying excited states and providing insight into thermal isomerization. The synthesized azobenzenes absorb at up to 600 nm and their thermal cis-lifetimes range from milliseconds to months. The most unique example can be driven from trans to cis with any wavelength from UV up to 595 nm, while still exhibiting a thermal cis-lifetime of 81 days. <br /> [GRAPHICS] <br /> .},
  language  = {en}
}
@misc{ViouxTaubert2014,
  author    = {Vioux, Andr{\´e} and Taubert, Andreas},
  title     = {Ionic liquids 2014 and selected papers from ILMAT 2013},
  series = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  journal   = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  number    = {1055},
  issn      = {1866-8372},
  doi       = {10.25932/publishup-47506},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-475062},
  pages     = {6},
  year      = {2014},
  language  = {en}
}
@misc{HeyneArltGessneretal.2020,
  author    = {Heyne, Benjamin and Arlt, Kristin and Geßner, Andr{\´e} and Richter, Alexander F. and D{\"o}blinger, Markus and Feldmann, Jochen and Taubert, Andreas and Wedel, Armin},
  title     = {Mixed Mercaptocarboxylic Acid Shells Provide Stable Dispersions of InPZnS/ZnSe/ZnS Multishell Quantum Dots in Aqueous Media},
  series = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  journal   = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  number    = {1026},
  issn      = {1866-8372},
  doi       = {10.25932/publishup-48603},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-486032},
  pages     = {26},
  year      = {2020},
  abstract  = {Highly luminescent indium phosphide zinc sulfide (InPZnS) quantum dots (QDs), with zinc selenide/zinc sulfide (ZnSe/ZnS) shells, were synthesized. The QDs were modified via a post-synthetic ligand exchange reaction with 3-mercaptopropionic acid (MPA) and 11-mercaptoundecanoic acid (MUA) in different MPA:MUA ratios, making this study the first investigation into the effects of mixed ligand shells on InPZnS QDs. Moreover, this article also describes an optimized method for the correlation of the QD size vs. optical absorption of the QDs. Upon ligand exchange, the QDs can be dispersed in water. Longer ligands (MUA) provide more stable dispersions than short-chain ligands. Thicker ZnSe/ZnS shells provide a better photoluminescence quantum yield (PLQY) and higher emission stability upon ligand exchange. Both the ligand exchange and the optical properties are highly reproducible between different QD batches. Before dialysis, QDs with a ZnS shell thickness of ~4.9 monolayers (ML), stabilized with a mixed MPA:MUA (mixing ratio of 1:10), showed the highest PLQY, at ~45\%. After dialysis, QDs with a ZnS shell thickness of ~4.9 ML, stabilized with a mixed MPA:MUA and a ratio of 1:10 and 1:100, showed the highest PLQYs, of ~41\%. The dispersions were stable up to 44 days at ambient conditions and in the dark. After 44 days, QDs with a ZnS shell thickness of ~4.9 ML, stabilized with only MUA, showed the highest PLQY, of ~34\%.},
  language  = {en}
}
@misc{TaoLiuWuetal.2020,
  author    = {Tao, Lumi and Liu, Yuchuan and Wu, Dan and Wei, Qiao-Hua and Taubert, Andreas and Xie, Zailai},
  title     = {Luminescent Ionogels with Excellent Transparency, High Mechanical Strength, and High Conductivity},
  series = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  journal   = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  number    = {1058},
  issn      = {1866-8372},
  doi       = {10.25932/publishup-48733},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-487334},
  pages     = {13},
  year      = {2020},
  abstract  = {The paper describes a new kind of ionogel with both good mechanical strength and high conductivity synthesized by confining the ionic liquid (IL) 1-butyl-3-methylimidazolium bis(trifluoromethane sulfonyl)imide ([Bmim][NTf₂]) within an organic-inorganic hybrid host. The organic-inorganic host network was synthesized by the reaction of methyltrimethoxysilane (MTMS), tetraethoxysilane (TEOS), and methyl methacrylate (MMA) in the presence of a coupling agent, offering the good mechanical strength and rapid shape recovery of the final products. The silane coupling agent 3-methacryloxypropyltrimethoxysilane (KH-570) plays an important role in improving the mechanical strength of the inorganic-organic hybrid, because it covalently connected the organic component MMA and the inorganic component SiO₂. Both the thermal stability and mechanical strength of the ionogel significantly increased by the addition of IL. The immobilization of [Bmim][NTf₂] within the ionogel provided the final ionogel with an ionic conductivity as high as ca. 0.04 S cm⁻¹ at 50 °C. Moreover, the hybrid ionogel can be modified with organosilica-modified carbon dots within the network to yield a transparent and flexible ionogel with strong excitation-dependent emission between 400 and 800 nm. The approach is, therefore, a blueprint for the construction of next-generation multifunctional ionogels.},
  language  = {en}
}
@article{NeffeLoewenbergJulichGruneretal.2021,
  author    = {Neffe, Axel T. and L{\"o}wenberg, Candy and Julich-Gruner, Konstanze K. and Behl, Marc and Lendlein, Andreas},
  title     = {Thermally-induced shape-memory behavior of degradable gelatin-based networks},
  series = {International journal of molecular sciences},
  volume    = {22},
  journal   = {International journal of molecular sciences},
  number    = {11},
  publisher = {Molecular Diversity Preservation International},
  address   = {Basel},
  issn      = {1422-0067},
  doi       = {10.3390/ijms22115892},
  pages     = {15},
  year      = {2021},
  abstract  = {Shape-memory hydrogels (SMH) are multifunctional, actively-moving polymers of interest in biomedicine. In loosely crosslinked polymer networks, gelatin chains may form triple helices, which can act as temporary net points in SMH, depending on the presence of salts. Here, we show programming and initiation of the shape-memory effect of such networks based on a thermomechanical process compatible with the physiological environment. The SMH were synthesized by reaction of glycidylmethacrylated gelatin with oligo(ethylene glycol) (OEG) alpha,omega-dithiols of varying crosslinker length and amount. Triple helicalization of gelatin chains is shown directly by wide-angle X-ray scattering and indirectly via the mechanical behavior at different temperatures. The ability to form triple helices increased with the molar mass of the crosslinker. Hydrogels had storage moduli of 0.27-23 kPa and Young's moduli of 215-360 kPa at 4 degrees C. The hydrogels were hydrolytically degradable, with full degradation to water-soluble products within one week at 37 degrees C and pH = 7.4. A thermally-induced shape-memory effect is demonstrated in bending as well as in compression tests, in which shape recovery with excellent shape-recovery rates R-r close to 100\% were observed. In the future, the material presented here could be applied, e.g., as self-anchoring devices mechanically resembling the extracellular matrix.},
  language  = {en}
}
@article{BastianRobelSchmidtetal.2021,
  author    = {Bastian, Philipp U. and Robel, Nathalie and Schmidt, Peter and Schrumpf, Tim and G{\"u}nter, Christina and Roddatis, Vladimir and Kumke, Michael U.},
  title     = {Resonance energy transfer to track the motion of lanthanide ions},
  series = {Biosensors : open access journal},
  volume    = {11},
  journal   = {Biosensors : open access journal},
  number    = {12},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2079-6374},
  doi       = {10.3390/bios11120515},
  pages     = {23},
  year      = {2021},
  abstract  = {The imagination of clearly separated core-shell structures is already outdated by the fact, that the nanoparticle core-shell structures remain in terms of efficiency behind their respective bulk material due to intermixing between core and shell dopant ions. In order to optimize the photoluminescence of core-shell UCNP the intermixing should be as small as possible and therefore, key parameters of this process need to be identified. In the present work the Ln(III) ion migration in the host lattices NaYF4 and NaGdF4 was monitored. These investigations have been performed by laser spectroscopy with help of lanthanide resonance energy transfer (LRET) between Eu(III) as donor and Pr(III) or Nd(III) as acceptor. The LRET is evaluated based on the Forster theory. The findings corroborate the literature and point out the migration of ions in the host lattices. Based on the introduced LRET model, the acceptor concentration in the surrounding of one donor depends clearly on the design of the applied core-shell-shell nanoparticles. In general, thinner intermediate insulating shells lead to higher acceptor concentration, stronger quenching of the Eu(III) donor and subsequently stronger sensitization of the Pr(III) or the Nd(III) acceptors. The choice of the host lattice as well as of the synthesis temperature are parameters to be considered for the intermixing process.},
  language  = {en}
}
@phdthesis{Nie2022,
  author    = {Nie, Yan},
  title     = {Modulating keratinocyte and induced pluripotent stem cell behavior by microenvironment design or temperature control},
  pages     = {xiv, 100},
  year      = {2022},
  abstract  = {Under the in vivo condition, a cell is continually interacting with its surrounding microenvironment, which is composed of its neighboring cells and the extracellular matrix (ECM). These components generate and transmit the microenvironmental signals to regulate the fate and function of the target cells. Except the signals from the microenvironment, stimuli from the ambient environment, such as temperature changes, also play an important in modulating the cell behaviors, which are considered as regulators from the macroenvironment. In this regard, recapitulation of these environmental factors to steer cell function will be of crucial importance for therapeutic purposes and tissue regeneration. Although the role of a variety of environmental factors has been evaluated, it is still challenging to identify and provide the appropriate factors, which are required for optimizing the survival of cells and for ensuring effective cell functions. Thus, in vitro recreating the environmental factors that are present in the extracellular environment would help to understand the mechanism of how cells sense and process those environmental signals. In this context, this thesis is aimed to harness these environmental parameters to guide cell responses. Here, human induced pluripotent stem cells (hiPSCs) and human keratinocytes (KTCs), HaCaT cells, were used to investigate the impact of signals from the microenvironment or stimuli from the macroenvironment. Firstly, polydopamine (PDA) or chitosan (CS) modifications were applied to generate different substrate surfaces for hiPSCs and KTCs (Chapter 4 to Chapter 6). Our results showed that the PDA modification was efficient to increase the cell-substrate adhesion and consequently promoted cell spreading. While CS modification was able to decrease the cell-substrate adhesion and enhance the cell-cell interaction, which enabled the morphology shift from monolayered cells to multicellular spheroids. The quantitative result was acquired using the atomic force microscopy (AFM)-based single-cell force spectroscopy. The balance between the cell-substrate and cell-cell adhesion yielded a net force, which determined the preference of the cell to adhere to its neighboring cells or to the substrate. The difference in the adhesive behaviors further affected the cellular function, such as the proliferation and differentiation potential of both hiPSCs and HaCaT cells. Next, the cyclic temperature changes (ΔT) were selected here to study the influence of macroenvironmental stimuli on hiPSCs and KTCs (Chapter 7 and Chapter 8). The macroenvironmental temperature ranging from 10.0 ± 0.1 °C to 37.0 ± 0.1 °C was achieved using a thermal chamber equipped with a temperature controller. This temperature range was selected to explore the responses of hiPSCs to the extreme environments, while a temperature variation between 25.0 ± 0.1 °C and 37.0 ± 0.1 °C was applied to mimic the ambient temperature variations experienced by the skin epithelial KTCs. The ΔT led to cell stiffening in both hiPSCs and HaCaT cells in a cytoskeleton-dependent manner, which was measured by AFM. Specifically, in hiPSCs, the cell stiffening was resulted from the rearrangement of the actin skeleton; in HaCaT cells, was due to the difference of the Keratin (KRT) filaments. Except for inducing cell hardening, ΔT also caused differences in the protein expression profiles in hiPSCs or HaCaT cells, compared to those without ΔT treatment, which might be attributed to the alterations in their cytoskeleton structures. To sum up, the results of the thesis demonstrated how individual factors from the micro-/macro-environment can be harnessed to modulate the behaviors of hiPSCs and HaCaT cells. Engineering the microenvironmental cues using surface modification and exploiting the macroenvironmental stimuli through temperature control were identified as precise and potent approaches to steer hiPSC and HaCaT cell behaviors. The application of AFM served as a non-invasive and real-time monitoring platform to trace the change in cell topography and mechanics induced by the environmental signals, which provide novel insights into the cell-environment interactions.},
  language  = {en}
}
@misc{SarauliXuDietzeletal.2014,
  author    = {Sarauli, David and Xu, Chenggang and Dietzel, Birgit and Schulz, Burkhard and Lisdat, Fred},
  title     = {A multilayered sulfonated polyaniline network with entrapped pyrroloquinoline quinone-dependent glucose dehydrogenase},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-98744},
  year      = {2014},
  abstract  = {A feasible approach to construct multilayer films of sulfonated polyanilines - PMSA1 and PABMSA1 - containing different ratios of aniline, 2-methoxyaniline-5-sulfonic acid (MAS) and 3-aminobenzoic acid (AB), with the entrapped redox enzyme pyrroloquinoline quinone-dependent glucose dehydrogenase (PQQ-GDH) on Au and ITO electrode surfaces, is described. The formation of layers has been followed and confirmed by electrochemical impedance spectroscopy (EIS), which demonstrates that the multilayer assembly can be achieved in a progressive and uniform manner. The gold and ITO electrodes subsequently modified with PMSA1:PQQ-GDH and PABMSA1 films are studied by cyclic voltammetry (CV) and UV-Vis spectroscopy which show a significant direct bioelectrocatalytical response to the oxidation of the substrate glucose without any additional mediator. This response correlates linearly with the number of deposited layers. Furthermore, the constructed polymer/enzyme multilayer system exhibits a rather good long-term stability, since the catalytic current response is maintained for more than 60\% of the initial value even after two weeks of storage. This verifies that a productive interaction of the enzyme embedded in the film of substituted polyaniline can be used as a basis for the construction of bioelectronic units, which are useful as indicators for processes liberating glucose and allowing optical and electrochemical transduction.},
  language  = {en}
}
@article{LuReichetzederPrehnetal.2018,
  author    = {Lu, Yong-Ping and Reichetzeder, Christoph and Prehn, Cornelia and Yin, Liang-Hong and Yun, Chen and Zeng, Shufei and Chu, Chang and Adamski, Jerzy and Hocher, Berthold},
  title     = {Cord blood Lysophosphatidylcholine 16:1 is positively associated with birth weight},
  series = {Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry and pharmacology},
  volume    = {45},
  journal   = {Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry and pharmacology},
  number    = {2},
  publisher = {Karger},
  address   = {Basel},
  issn      = {1015-8987},
  doi       = {10.1159/000487118},
  pages     = {614 -- 624},
  year      = {2018},
  abstract  = {Background/Aims: Impaired birth outcomes, like low birth weight, have consistently been associated with increased disease susceptibility to hypertension in later life. Alterations in the maternal or fetal metabolism might impact on fetal growth and influence birth outcomes. Discerning associations between the maternal and fetal metabolome and surrogate parameters of fetal growth could give new insight into the complex relationship between intrauterine conditions, birth outcomes, and later life disease susceptibility. Methods: Using flow injection tandem mass spectrometry, targeted metabolomics was performed in serum samples obtained from 226 mother/child pairs at delivery. Associations between neonatal birth weight and concentrations of 163 maternal and fetal metabolites were analyzed. Results: After FDR adjustment using the Benjamini-Hochberg procedure lysophosphatidylcholines (LPC) 14:0, 16:1, and 18:1 were strongly positively correlated with birth weight. In a stepwise linear regression model corrected for established confounding factors of birth weight, LPC 16: 1 showed the strongest independent association with birth weight (CI: 93.63 - 168.94; P = 6.94x10(-11)). The association with birth weight was stronger than classical confounding factors such as offspring sex (CI: - 258.81- -61.32; P = 0.002) and maternal smoking during pregnancy (CI: -298.74 - -29.51; P = 0.017). Conclusions: After correction for multiple testing and adjustment for potential confounders, LPC 16:1 showed a very strong and independent association with birth weight. The underlying molecular mechanisms linking fetal LPCs with birth weight need to be addressed in future studies. (c) 2018 The Author(s) Published by S. Karger AG, Basel},
  language  = {en}
}
@article{DengWangXuaetal.2020,
  author    = {Deng, Zijun and Wang, Weiwei and Xua, Xun and Gould, Oliver E. C. and Kratz, Karl and Ma, Nan and Lendlein, Andreas},
  title     = {Polymeric sheet actuators with programmable bioinstructivity},
  series = {PNAS},
  volume    = {117},
  journal   = {PNAS},
  number    = {4},
  publisher = {National Academy of Sciences},
  address   = {Washington, DC},
  issn      = {1091-6490},
  doi       = {10.1073/pnas.1910668117},
  pages     = {1895 -- 1901},
  year      = {2020},
  abstract  = {Stem cells are capable of sensing and processing environmental inputs, converting this information to output a specific cell lineage through signaling cascades. Despite the combinatorial nature of mechanical, thermal, and biochemical signals, these stimuli have typically been decoupled and applied independently, requiring continuous regulation by controlling units. We employ a programmable polymer actuator sheet to autonomously synchronize thermal and mechanical signals applied to mesenchymal stem cells (MSC5). Using a grid on its underside, the shape change of polymer sheet, as well as cell morphology, calcium (Ca2+) influx, and focal adhesion assembly, could be visualized and quantified. This paper gives compelling evidence that the temperature sensing and mechanosensing of MSC5 are interconnected via intracellular Ca2+. Up-regulated Ca2+ levels lead to a remarkable alteration of histone H3K9 acetylation and activation of osteogenic related genes. The interplay of physical, thermal, and biochemical signaling was utilized to accelerate the cell differentiation toward osteogenic lineage. The approach of programmable bioinstructivity provides a fundamental principle for functional biomaterials exhibiting multifaceted stimuli on differentiation programs. Technological impact is expected in the tissue engineering of periosteum for treating bone defects.},
  language  = {en}
}
@phdthesis{Friess2016,
  author    = {Frieß, Fabian},
  title     = {Shape-memory polymer micronetworks},
  school      = {Universit{\"a}t Potsdam},
  pages     = {xiv, 111 S.},
  year      = {2016},
  language  = {en}
}
@article{LauMaierBrauneetal.2021,
  author    = {Lau, Skadi and Maier, Anna and Braune, Steffen and Gossen, Manfred and Lendlein, Andreas},
  title     = {Effect of endothelial culture medium composition on platelet responses to polymeric biomaterials},
  series = {International journal of molecular sciences},
  volume    = {22},
  journal   = {International journal of molecular sciences},
  number    = {13},
  publisher = {Molecular Diversity Preservation International},
  address   = {Basel},
  issn      = {1422-0067},
  doi       = {10.3390/ijms22137006},
  pages     = {13},
  year      = {2021},
  abstract  = {Near-physiological in vitro thrombogenicity test systems for the evaluation of blood-contacting endothelialized biomaterials requires co-cultivation with platelets (PLT). However, the addition of PLT has led to unphysiological endothelial cell (EC) detachment in such in vitro systems. A possible cause for this phenomenon may be PLT activation triggered by the applied endothelial cell medium, which typically consists of basal medium (BM) and nine different supplements. To verify this hypothesis, the influence of BM and its supplements was systematically analyzed regarding PLT responses. For this, human platelet rich plasma (PRP) was mixed with BM, BM containing one of nine supplements, or with BM containing all supplements together. PLT adherence analysis was carried out in six-channel slides with plasma-treated cyclic olefin copolymer (COC) and poly(tetrafluoro ethylene) (PTFE, as a positive control) substrates as part of the six-channel slides in the absence of EC and under static conditions. PLT activation and aggregation were analyzed using light transmission aggregometry and flow cytometry (CD62P). Medium supplements had no effect on PLT activation and aggregation. In contrast, supplements differentially affected PLT adherence, however, in a polymer- and donor-dependent manner. Thus, the use of standard endothelial growth medium (BM + all supplements) maintains functionality of PLT under EC compatible conditions without masking the differences of PLT adherence on different polymeric substrates. These findings are important prerequisites for the establishment of a near-physiological in vitro thrombogenicity test system assessing polymer-based cardiovascular implant materials in contact with EC and PLT.},
  language  = {en}
}
@misc{DengWangXuaetal.2020,
  author    = {Deng, Zijun and Wang, Weiwei and Xua, Xun and Gould, Oliver E. C. and Kratz, Karl and Ma, Nan and Lendlein, Andreas},
  title     = {Polymeric sheet actuators with programmable bioinstructivity},
  series = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  journal   = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  number    = {4},
  issn      = {1866-8372},
  doi       = {10.25932/publishup-51549},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-515490},
  pages     = {9},
  year      = {2020},
  abstract  = {Stem cells are capable of sensing and processing environmental inputs, converting this information to output a specific cell lineage through signaling cascades. Despite the combinatorial nature of mechanical, thermal, and biochemical signals, these stimuli have typically been decoupled and applied independently, requiring continuous regulation by controlling units. We employ a programmable polymer actuator sheet to autonomously synchronize thermal and mechanical signals applied to mesenchymal stem cells (MSC5). Using a grid on its underside, the shape change of polymer sheet, as well as cell morphology, calcium (Ca2+) influx, and focal adhesion assembly, could be visualized and quantified. This paper gives compelling evidence that the temperature sensing and mechanosensing of MSC5 are interconnected via intracellular Ca2+. Up-regulated Ca2+ levels lead to a remarkable alteration of histone H3K9 acetylation and activation of osteogenic related genes. The interplay of physical, thermal, and biochemical signaling was utilized to accelerate the cell differentiation toward osteogenic lineage. The approach of programmable bioinstructivity provides a fundamental principle for functional biomaterials exhibiting multifaceted stimuli on differentiation programs. Technological impact is expected in the tissue engineering of periosteum for treating bone defects.},
  language  = {en}
}
@article{SchoenemannKocKarthaeuseretal.2021,
  author    = {Sch{\"o}nemann, Eric and Koc, Julian and Karth{\"a}user, Jana and {\"O}zcan, Onur and Schanzenbach, Dirk and Schardt, Lisa and Rosenhahn, Axel and Laschewsky, Andr{\´e}},
  title     = {Sulfobetaine methacrylate polymers of unconventional polyzwitterion architecture and their antifouling properties},
  series = {Biomacromolecules : an interdisciplinary journal focused at the interface of polymer science and the biological sciences},
  volume    = {22},
  journal   = {Biomacromolecules : an interdisciplinary journal focused at the interface of polymer science and the biological sciences},
  number    = {4},
  publisher = {American Chemical Society},
  address   = {Washington},
  issn      = {1525-7797},
  doi       = {10.1021/acs.biomac.0c01705},
  pages     = {1494 -- 1508},
  year      = {2021},
  abstract  = {Combining high hydrophilicity with charge neutrality, polyzwitterions are intensely explored for their high biocompatibility and low-fouling properties. Recent reports indicated that in addition to charge neutrality, the zwitterion's segmental dipole orientation is an important factor for interacting with the environment. Accordingly, a series of polysulfobetaines with a novel architecture was designed, in which the cationic and anionic groups of the zwitterionic moiety are placed at equal distances from the backbone. They were investigated by in vitro biofouling assays, covering proteins of different charges and model marine organisms. All polyzwitterion coatings reduced the fouling effectively compared to model polymer surfaces of poly(butyl methacrylate), with a nearly equally good performance as the reference polybetaine poly(3-(N-(2-(methacryloyloxy)ethyl)-N,N-dimethylammonio)propanesulfonate). The specific fouling resistance depended on the detailed chemical structure of the polyzwitterions. Still, while clearly affecting the performance, the precise dipole orientation of the sulfobetaine group in the polyzwitterions seems overall to be only of secondary importance for their antifouling behavior.},
  language  = {en}
}
@article{TungSunWangetal.2021,
  author    = {Tung, Wing Tai and Sun, Xianlei and Wang, Weiwei and Xu, Xun and Ma, Nan and Lendlein, Andreas},
  title     = {Structure, mechanical properties and degradation behavior of electrospun PEEU fiber meshes and films},
  series = {MRS advances : a journal of the Materials Research Society (MRS)},
  volume    = {6},
  journal   = {MRS advances : a journal of the Materials Research Society (MRS)},
  number    = {10},
  publisher = {Springer Nature Switzerland AG},
  address   = {Cham},
  issn      = {2059-8521},
  doi       = {10.1557/s43580-020-00001-0},
  pages     = {276 -- 282},
  year      = {2021},
  abstract  = {The capability of a degradable implant to provide mechanical support depends on its degradation behavior. Hydrolytic degradation was studied for a polyesteretherurethane (PEEU70), which consists of poly(p-dioxanone) (PPDO) and poly(epsilon-caprolactone) (PCL) segments with a weight ratio of 70:30 linked by diurethane junction units. PEEU70 samples prepared in the form of meshes with average fiber diameters of 1.5 mu m (mesh1.5) and 1.2 mu m (mesh1.2), and films were sterilized and incubated in PBS at 37 degrees C with 5 vol\% CO2 supply for 1 to 6 weeks. Degradation features, such as cracks or wrinkles, became apparent from week 4 for all samples. Mass loss was found to be 11 wt\%, 6 wt\%, and 4 wt\% for mesh1.2, mesh1.5, and films at week 6. The elongation at break decreased to under 20\% in two weeks for mesh1.2. In case of the other two samples, this level of degradation was achieved after 4 weeks. The weight average molecular weight of both PEEU70 mesh and film samples decreased to below 30 kg/mol when elongation at break dropped below 20\%. The time period of sustained mechanical stability of PEEU70-based meshes depends on the fiber diameter and molecular weight.},
  language  = {en}
}
@misc{LohrenBornhorstGallaetal.2015,
  author    = {Lohren, Hanna and Bornhorst, Julia and Galla, Hans-Joachim and Schwerdtle, Tanja},
  title     = {The blood-cerebrospinal fluid barrier},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-82089},
  year      = {2015},
  abstract  = {Exposure to organic mercury compounds promotes primarily neurological effects. Although methylmercury is recognized as a potent neurotoxicant, its transfer into the central nervous system (CNS) is not fully evaluated. While methylmercury and thiomersal pass the blood-brain barrier, limited data are available regarding the second brain regulating interface, the blood-cerebrospinal fluid (CSF) barrier. This novel study was designed to investigate the effects of organic as well as inorganic mercury compounds on, and their transfer across, a porcine in vitro model of the blood-CSF barrier for the first time. The barrier system is significantly more sensitive towards organic Hg compounds as compared to inorganic compounds regarding the endpoints cytotoxicity and barrier integrity. Whereas there are low transfer rates from the blood side to the CSF side, our results strongly indicate an active transfer of the organic mercury compounds out of the CSF. These results are the first to demonstrate an efflux of organic mercury compounds regarding the CNS and provide a completely new approach in the understanding of mercury compounds specific transport.},
  language  = {en}
}
@article{FigueroaCamposPerezBlocketal.2021,
  author    = {Figueroa Campos, Gustavo Adolfo and Perez, Jeffrey Paulo H. and Block, Inga and Sagu Tchewonpi, Sorel and Saravia Celis, Pedro and Taubert, Andreas and Rawel, Harshadrai Manilal},
  title     = {Preparation of activated carbons from spent coffee and coffee parchment and assessment of their adsorbent efficiency},
  series = {Processes : open access journal},
  volume    = {9},
  journal   = {Processes : open access journal},
  number    = {8},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2227-9717},
  doi       = {10.3390/pr9081396},
  pages     = {18},
  year      = {2021},
  abstract  = {The valorization of coffee wastes through modification to activated carbon has been considered as a low-cost adsorbent with prospective to compete with commercial carbons. So far, very few studies have referred to the valorization of coffee parchment into activated carbon. Moreover, low-cost and efficient activation methods need to be more investigated. The aim of this work was to prepare activated carbon from spent coffee grounds and parchment, and to assess their adsorption performance. The co-calcination processing with calcium carbonate was used to prepare the activated carbons, and their adsorption capacity for organic acids, phenolic compounds and proteins was evaluated. Both spent coffee grounds and parchment showed yields after the calcination and washing treatments of around 9.0\%. The adsorption of lactic acid was found to be optimal at pH 2. The maximum adsorption capacity of lactic acid with standard commercial granular activated carbon was 73.78 mg/g, while the values of 32.33 and 14.73 mg/g were registered for the parchment and spent coffee grounds activated carbons, respectively. The Langmuir isotherm showed that lactic acid was adsorbed as a monolayer and distributed homogeneously on the surface. Around 50\% of total phenols and protein content from coffee wastewater were adsorbed after treatment with the prepared activated carbons, while 44, 43, and up to 84\% of hydrophobic compounds were removed using parchment, spent coffee grounds and commercial activated carbon, respectively; the adsorption efficiencies of hydrophilic compounds ranged between 13 and 48\%. Finally, these results illustrate the potential valorization of coffee by-products parchment and spent coffee grounds into activated carbon and their use as low-cost adsorbent for the removal of organic compounds from aqueous solutions.},
  language  = {en}
}
@article{SchulzeMakuchWagnerKounavesetal.2018,
  author    = {Schulze-Makuch, Dirk and Wagner, Dirk and Kounaves, Samuel P. and Mangelsdorf, Kai and Devine, Kevin G. and de Vera, Jean-Pierre and Schmitt-Kopplin, Philippe and Grossart, Hans-Peter and Parro, Victor and Kaupenjohann, Martin and Galy, Albert and Schneider, Beate and Airo, Alessandro and Froesler, Jan and Davila, Alfonso F. and Arens, Felix L. and Caceres, Luis and Cornejo, Francisco Solis and Carrizo, Daniel and Dartnell, Lewis and DiRuggiero, Jocelyne and Flury, Markus and Ganzert, Lars and Gessner, Mark O. and Grathwohl, Peter and Guan, Lisa and Heinz, Jacob and Hess, Matthias and Keppler, Frank and Maus, Deborah and McKay, Christopher P. and Meckenstock, Rainer U. and Montgomery, Wren and Oberlin, Elizabeth A. and Probst, Alexander J. and Saenz, Johan S. and Sattler, Tobias and Schirmack, Janosch and Sephton, Mark A. and Schloter, Michael and Uhl, Jenny and Valenzuela, Bernardita and Vestergaard, Gisle and Woermer, Lars and Zamorano, Pedro},
  title     = {Transitory microbial habitat in the hyperarid Atacama Desert},
  series = {Proceedings of the National Academy of Sciences of the United States of America},
  volume    = {115},
  journal   = {Proceedings of the National Academy of Sciences of the United States of America},
  number    = {11},
  publisher = {National Acad. of Sciences},
  address   = {Washington},
  issn      = {0027-8424},
  doi       = {10.1073/pnas.1714341115},
  pages     = {2670 -- 2675},
  year      = {2018},
  language  = {en}
}
@article{TungMaringXuetal.2022,
  author    = {Tung, Wing Tai and Maring, Janita A. and Xu, Xun and Liu, Yue and Becker, Matthias and Somesh, Dipthi Bachamanda and Klose, Kristin and Wang, Weiwei and Sun, Xianlei and Ullah, Imran and Kratz, Karl and Neffe, Axel T. and Stamm, Christof and Ma, Nan and Lendlein, Andreas},
  title     = {In vivo performance of a cell and factor free multifunctional fiber mesh modulating postinfarct myocardial remodeling},
  series = {Advanced Functional Materials},
  volume    = {32},
  journal   = {Advanced Functional Materials},
  number    = {31},
  publisher = {Wiley},
  address   = {Weinheim},
  issn      = {1616-301X},
  doi       = {10.1002/adfm.202110179},
  pages     = {17},
  year      = {2022},
  abstract  = {Guidance of postinfarct myocardial remodeling processes by an epicardial patch system may alleviate the consequences of ischemic heart disease. As macrophages are highly relevant in balancing immune response and regenerative processes their suitable instruction would ensure therapeutic success. A polymeric mesh capable of attracting and instructing monocytes by purely physical cues and accelerating implant degradation at the cell/implant interface is designed. In a murine model for myocardial infarction the meshes are compared to those either coated with extracellular matrix or loaded with induced cardiomyocyte progenitor cells. All implants promote macrophage infiltration and polarization in the epicardium, which is verified by in vitro experiments. 6 weeks post-MI, especially the implantation of the mesh attenuates left ventricular adverse remodeling processes as shown by reduced infarct size (14.7\% vs 28-32\%) and increased wall thickness (854 mu m vs 400-600 mu m), enhanced angiogenesis/arteriogenesis (more than 50\% increase compared to controls and other groups), and improved heart function (ejection fraction = 36.8\% compared to 12.7-31.3\%). Upscaling as well as process controls is comprehensively considered in the presented mesh fabrication scheme to warrant further progression from bench to bedside.},
  language  = {en}
}
@article{SandmannMuenzbergBresseletal.2022,
  author    = {Sandmann, Michael and M{\"u}nzberg, Marvin and Bressel, Lena and Reich, Oliver and Hass, Roland},
  title     = {Inline monitoring of high cell density cultivation of Scenedesmus rubescens in a mesh ultra-thin layer photobioreactor by photon density wave spectroscopy},
  series = {BMC Research Notes / Biomed Central},
  volume    = {15},
  journal   = {BMC Research Notes / Biomed Central},
  number    = {1},
  publisher = {Biomed Central (London)},
  address   = {London},
  issn      = {1756-0500},
  doi       = {10.1186/s13104-022-05943-2},
  pages     = {7},
  year      = {2022},
  abstract  = {Objective Due to multiple light scattering that occurs inside and between cells, quantitative optical spectroscopy in turbid biological suspensions is still a major challenge. This includes also optical inline determination of biomass in bioprocessing. Photon Density Wave (PDW) spectroscopy, a technique based on multiple light scattering, enables the independent and absolute determination of optical key parameters of concentrated cell suspensions, which allow to determine biomass during cultivation. Results A unique reactor type, called "mesh ultra-thin layer photobioreactor" was used to create a highly concentrated algal suspension. PDW spectroscopy measurements were carried out continuously in the reactor without any need of sampling or sample preparation, over 3 weeks, and with 10-min time resolution. Conventional dry matter content and coulter counter measurements have been employed as established offline reference analysis. The PBR allowed peak cell dry weight (CDW) of 33.4 g L-1. It is shown that the reduced scattering coefficient determined by PDW spectroscopy is strongly correlated with the biomass concentration in suspension and is thus suitable for process understanding. The reactor in combination with the fiber-optical measurement approach will lead to a better process management.},
  language  = {en}
}
@article{BuyinzaDereseNdakalaetal.2021,
  author    = {Buyinza, Daniel and Derese, Solomon and Ndakala, Albert and Heydenreich, Matthias and Yenesew, Abiy and Koch, Andreas and Oriko, Richard},
  title     = {A coumestan and a coumaronochromone from Millettia lasiantha},
  series = {Biochemical systematics and ecology},
  volume    = {97},
  journal   = {Biochemical systematics and ecology},
  publisher = {Elsevier},
  address   = {Oxford},
  issn      = {0305-1978},
  doi       = {10.1016/j.bse.2021.104277},
  pages     = {5},
  year      = {2021},
  abstract  = {The manuscript describes the phytochemical investigation of the roots, leaves and stem bark of Millettia lasiantha resulting in the isolation of twelve compounds including two new isomeric isoflavones lascoumestan and las-coumaronochromone. The structures of the new compounds were determined using different spectroscopic techniques.},
  language  = {en}
}