@article{MusalekKokstejnPapezetal.2017,
  author    = {Musalek, Martin and Kokstejn, Jakub and Papez, Pavel and Scheffler, Christiane and Mumm, Rebekka and Czernitzki, Anna-Franziska and Koziel, Slawomir},
  title     = {Impact of normal weight obesity on fundamental motor skills in pre-school children aged 3 to 6 years},
  series = {Journal of biological and clinical anthropology : Anthropologischer Anzeiger ; Mitteilungsorgan der Gesellschaft f{\"u}r Anthropologie},
  volume    = {74},
  journal   = {Journal of biological and clinical anthropology : Anthropologischer Anzeiger ; Mitteilungsorgan der Gesellschaft f{\"u}r Anthropologie},
  publisher = {Schweizerbart},
  address   = {Stuttgart},
  issn      = {0003-5548},
  doi       = {10.1127/anthranz/2017/0752},
  pages     = {203 -- 212},
  year      = {2017},
  abstract  = {Normal weight obesity is defined as having excessive body fat, but normal BMI. Even though previous research revealed that excessive body fat in children inhibited their physical activity and decreased motor performance, there has been only little evidence about motor performance of normal weight obese children. This study aims to establish whether normal weight obese pre-school children aged 3-6 years will have a significantly worse level of fundamental motor skills compared to normal weight non-obese counterparts. The research sample consisted of 152 pre-schoolers selected from a specific district of Prague, the Czech Republic. According to values from four skinfolds: triceps, subscapula, suprailiaca, calf, and BMI three categories of children aged 3-6 years were determined: A) normal weight obese n = 51; B) normal weight non-obese n = 52; C) overweight and obese n = 49. The Movement Assessment Battery for Children (MABC-2) was used for the assessment of fundamental motor skills. Normal weight obese children had significantly higher amount of adipose tissue p < 0.001 than normal weight non-obese children but the same average BMI. Moreover, normal weight obese children did not have significantly less amount of subcutaneous fat on triceps and calf compared to their overweight and obese peers. In majority of MABC-2 tests, normal weight obese pre-schoolers showed the poorest performance. Moreover, normal weight obese children had significantly worse total standard score = 38.82 compared to normal weight non-obese peers = 52.27; p < 0.05. In addition, normal weight obese children had a more than three times higher frequency OR = 3.69 CI95\% (1.10; 12.35) of severe motor deficit performance <= 5th centile of the MABC-2 norm. These findings are strongly alarming since indices like BMI are not able to identify normal weight obese individual. We recommend verifying real portion of normal weight obese children as they are probably in higher risk of health and motor problems than overweight and obese population due to their low lean mass.},
  language  = {en}
}
@article{ReinickeReesEspeeletal.2017,
  author    = {Reinicke, Stefan and Rees, Huw C. and Espeel, Pieter and Vanparijs, Nane and Bisterfeld, Carolin and Dick, Markus and Rosencrantz, Ruben R. and Brezesinski, Gerald and de Geest, Bruno G. and Du Prez, Filip E. and Pietruszka, J{\"o}rg and B{\"o}ker, Alexander},
  title     = {Immobilization of 2-Deoxy-D-ribose-5-phosphate Aldolase in Polymeric Thin Films via the Langmuir-Schaefer Technique},
  series = {ACS applied materials \& interfaces},
  volume    = {9},
  journal   = {ACS applied materials \& interfaces},
  publisher = {American Chemical Society},
  address   = {Washington},
  issn      = {1944-8244},
  doi       = {10.1021/acsami.6b13632},
  pages     = {8317 -- 8326},
  year      = {2017},
  abstract  = {A synthetic protocol for the fabrication of ultrathin polymeric films containing the enzyme 2-deoxy-D-ribose-5-phosphate aldolase from Escherichia coli (DERA(EC)) is presented. Ultrathin enzymatically active films are useful for applications in which only small quantities of active material are needed and at the same time quick response and contact times without diffusion limitation are wanted. We show how DERA as an exemplary enzyme can be immobilized in a thin polymer layer at the air-water interface and transferred to a suitable support by the Langmuir-Schaefer technique under full conservation of enzymatic activity. The polymer in use is a poly(N-isopropylacrylamide-co-N-2-thiolactone acrylamide) (P(NIPAAm-co-TlaAm)) statistical copolymer in which the thiolactone units serve a multitude of purposes including hydrophobization of the polymer, covalent binding of the enzyme and the support and finally cross-linking of the polymer matrix. The application of this type of polymer keeps the whole approach simple as additional cocomponents such as cross-linkers are avoided.},
  language  = {en}
}
@phdthesis{Barbirz2017,
  author    = {Barbirz, Stefanie},
  title     = {Highly specific binders for bacterial polysaccharides},
  school      = {Universit{\"a}t Potsdam},
  pages     = {167},
  year      = {2017},
  language  = {en}
}
@article{BoginSchefflerHermanussen2017,
  author    = {Bogin, Barry and Scheffler, Christiane and Hermanussen, Michael},
  title     = {Global effects of income and income inequality on adult height and sexual dimorphism in height},
  series = {American journal of human biology : the official journal of the Human Biology Council},
  volume    = {29},
  journal   = {American journal of human biology : the official journal of the Human Biology Council},
  number    = {2},
  publisher = {Wiley},
  address   = {Hoboken},
  issn      = {1042-0533},
  doi       = {10.1002/ajhb.22980},
  pages     = {11},
  year      = {2017},
  abstract  = {Objectives: Average adult height of a population is considered a biomarker of the quality of the health environment and economic conditions. The causal relationships between height and income inequality are not well understood. We analyze data from 169 countries for national average heights of men and women and national-level economic factors to test two hypotheses: (1) income inequality has a greater association with average adult height than does absolute income; and (2) neither income nor income inequality has an effect on sexual dimorphism in height. Methods: Average height data come from the NCD-RisC health risk factor collaboration. Economic indicators are derived from the World Bank data archive and include gross domestic product (GDP), Gross National Income per capita adjusted for personal purchasing power (GNI_ PPP), and income equality assessed by the Gini coefficient calculated by the Wagstaff method. Results: Hypothesis 1 is supported. Greater income equality is most predictive of average height for both sexes. GNI_ PPP explains a significant, but smaller, amount of the variation. National GDP has no association with height. Hypothesis 2 is rejected. With greater average adult height there is greater sexual dimorphism. Conclusions: Findings support a growing literature on the pernicious effects of inequality on growth in height and, by extension, on health. Gradients in height reflect gradients in social disadvantage. Inequality should be considered a pollutant that disempowers people from the resources needed for their own healthy growth and development and for the health and good growth of their children.},
  language  = {en}
}
@article{PatelWutkeLenzetal.2017,
  author    = {Patel, Riddhi P. and Wutke, Saskia and Lenz, Dorina and Mukherjee, Shomita and Ramakrishnan, Uma and Veron, Geraldine and Fickel, J{\"o}rns and Wilting, Andreas and F{\"o}rster, Daniel W.},
  title     = {Genetic Structure and Phylogeography of the Leopard Cat (Prionailurus bengalensis) Inferred from Mitochondrial Genomes},
  series = {Journal of Heredity},
  volume    = {108},
  journal   = {Journal of Heredity},
  number    = {4},
  publisher = {Oxford Univ. Press},
  address   = {Cary},
  issn      = {0022-1503},
  doi       = {10.1093/jhered/esx017},
  pages     = {349 -- 360},
  year      = {2017},
  abstract  = {The Leopard cat Prionailurus bengalensis is a habitat generalist that is widely distributed across Southeast Asia. Based on morphological traits, this species has been subdivided into 12 subspecies. Thus far, there have been few molecular studies investigating intraspecific variation, and those had been limited in geographic scope. For this reason, we aimed to study the genetic structure and evolutionary history of this species across its very large distribution range in Asia. We employed both PCR-based (short mtDNA fragments, 94 samples) and high throughput sequencing based methods (whole mitochondrial genomes, 52 samples) on archival, noninvasively collected and fresh samples to investigate the distribution of intraspecific genetic variation. Our comprehensive sampling coupled with the improved resolution of a mitochondrial genome analyses provided strong support for a deep split between Mainland and Sundaic Leopard cats. Although we identified multiple haplogroups within the species' distribution, we found no matrilineal evidence for the distinction of 12 subspecies. In the context of Leopard cat biogeography, we cautiously recommend a revision of the Prionailurus bengalensis subspecific taxonomy: namely, a reduction to 4 subspecies (2 mainland and 2 Sundaic forms).},
  language  = {en}
}
@phdthesis{Nagel2017,
  author    = {Nagel, Rebecca},
  title     = {Genetic and behavioral investigations into African weakly electric fish (Osteoglossomorpha: Mormyridae) speciation},
  school      = {Universit{\"a}t Potsdam},
  pages     = {121},
  year      = {2017},
  language  = {en}
}
@article{HolzloehnerHanack2017,
  author    = {Holzl{\"o}hner, Pamela and Hanack, Katja},
  title     = {Generation of murine monoclonal antibodies by hybridoma technology},
  series = {JoVE : Video journal},
  journal   = {JoVE : Video journal},
  number    = {119},
  publisher = {JoVE},
  address   = {Cambridge},
  issn      = {1940-087X},
  doi       = {10.3791/54832},
  pages     = {7},
  year      = {2017},
  abstract  = {Monoclonal antibodies are universal binding molecules and are widely used in biomedicine and research. Nevertheless, the generation of these binding molecules is time-consuming and laborious due to the complicated handling and lack of alternatives. The aim of this protocol is to provide one standard method for the generation of monoclonal antibodies using hybridoma technology. This technology combines two steps. Step 1 is an appropriate immunization of the animal and step 2 is the fusion of B lymphocytes with immortal myeloma cells in order to generate hybrids possessing both parental functions, such as the production of antibody molecules and immortality. The generated hybridoma cells were then recloned and diluted to obtain stable monoclonal cell cultures secreting the desired monoclonal antibody in the culture supernatant. The supernatants were tested in enzyme-linked immunosorbent assays (ELISA) for antigen specificity. After the selection of appropriate cell clones, the cells were transferred to mass cultivation in order to produce the desired antibody molecule in large amounts. The purification of the antibodies is routinely performed by affinity chromatography. After purification, the antibody molecule can be characterized and validated for the final test application. The whole process takes 8 to 12 months of development, and there is a high risk that the antibody will not work in the desired test system.},
  language  = {en}
}
@misc{DuncanRosa2017,
  author    = {Duncan, Susan and Rosa, Stefanie Nunes},
  title     = {Gaining insight into plant gene transcription using smFISH},
  series = {Transcription},
  volume    = {9},
  journal   = {Transcription},
  number    = {3},
  publisher = {Taylor \& Francis Group},
  address   = {Philadelphia},
  issn      = {2154-1264},
  doi       = {10.1080/21541264.2017.1372043},
  pages     = {166 -- 170},
  year      = {2017},
  abstract  = {Single molecule RNA fluorescent in situ hybridization (smFISH) enables gene transcription to be assessed at the cellular level. In this point of view article, we describe our recent smFISH research in the model plant Arabidopsis thaliana and discuss how this technique could further knowledge of plant gene transcription in the future.},
  language  = {en}
}
@phdthesis{Castellanos2017,
  author    = {Castellanos, Reynel Urrea},
  title     = {Functional characterization of FGT2, a positive regulator of heat stress memory},
  school      = {Universit{\"a}t Potsdam},
  pages     = {151},
  year      = {2017},
  language  = {en}
}
@phdthesis{deSouza2017,
  author    = {de Souza, Leonardo Perez},
  title     = {Functional characterization of biosynthesis and regulation of plant secondary metabolism},
  school      = {Universit{\"a}t Potsdam},
  pages     = {102},
  year      = {2017},
  language  = {en}
}
@article{BremerWolffThalhammeretal.2017,
  author    = {Bremer, Anne and Wolff, Martin and Thalhammer, Anja and Hincha, Dirk K.},
  title     = {Folding of intrinsically disordered plant LEA proteins is driven by glycerol-induced crowding and the presence of membranes},
  series = {The FEBS journal},
  volume    = {284},
  journal   = {The FEBS journal},
  publisher = {Wiley},
  address   = {Hoboken},
  issn      = {1742-464X},
  doi       = {10.1111/febs.14023},
  pages     = {919 -- 936},
  year      = {2017},
  abstract  = {Late embryogenesis abundant (LEA) proteins are related to cellular dehydration tolerance. Most LEA proteins are predicted to have no stable secondary structure in solution, i.e., to be intrinsically disordered proteins (IDPs), but they may acquire alpha-helical structure upon drying. In the model plant Arabidopsis thaliana, the LEA proteins COR15A and COR15B are highly induced upon cold treatment and are necessary for the plants to attain full freezing tolerance. Freezing leads to increased intracellular crowding due to dehydration by extracellular ice crystals. In vitro, crowding by high glycerol concentrations induced partial folding of COR15 proteins. Here, we have extended these investigations to two related proteins, LEA11 and LEA25. LEA25 is much longer than LEA11 and COR15A, but shares a conserved central sequence domain with the other two proteins. We have created two truncated versions of LEA25 (2H and 4H) to elucidate the structural and functional significance of this domain. Light scattering and CD spectroscopy showed that all five proteins were largely unstructured and monomeric in dilute solution. They folded in the presence of increasing concentrations of trifluoroethanol and glycerol. Additional folding was observed in the presence of glycerol and membranes. Fourier transform infra red spectroscopy revealed an interaction of the LEA proteins with membranes in the dry state leading to a depression in the gel to liquid-crystalline phase transition temperature. Liposome stability assays revealed a cryoprotective function of the proteins. The C- and N-terminal extensions of LEA25 were important in cryoprotection, as the central domain itself (2H, 4H) only provided a low level of protection.},
  language  = {en}
}
@article{SanderEccardHeim2017,
  author    = {Sander, Martha Maria and Eccard, Jana and Heim, Wieland},
  title     = {Flight range estimation of migrant yellow-browed warblers phylloscopus inornatus on the East Asian flyway},
  series = {Bird study : the journal of the British Trust for Ornithology},
  volume    = {64},
  journal   = {Bird study : the journal of the British Trust for Ornithology},
  publisher = {Taylor \& Francis},
  address   = {Abingdon},
  issn      = {0006-3657},
  doi       = {10.1080/00063657.2017.1409696},
  pages     = {569 -- 572},
  year      = {2017},
  abstract  = {Fat loads were quantified for 2125 Yellow-browed Warblers Phylloscopus inornatus trapped at a stop-over site in Far East Russia during autumn migration. Flight ranges of 660-820km were estimated for the fattest individuals, suggesting that they would need to stop for refuelling at least six times to reach their wintering areas in South East Asia.},
  language  = {en}
}
@article{FruscalzoFrommerLonderoetal.2017,
  author    = {Fruscalzo, Arrigo and Frommer, Julia-Marie and Londero, Ambrogio P. and Henze, Andrea and Schweigert, Florian J. and Nofer, Jerzy-Roch and Steinhard, Johannes and Klockenbusch, Walter and Schmitz, Ralf and Raila, Jens},
  title     = {First trimester TTR-RBP4-ROH complex and angiogenic factors in the prediction of small for gestational age infant's outcome},
  series = {Archives of gynecology and obstetrics},
  volume    = {295},
  journal   = {Archives of gynecology and obstetrics},
  publisher = {Springer},
  address   = {Heidelberg},
  issn      = {0932-0067},
  doi       = {10.1007/s00404-017-4338-4},
  pages     = {1157 -- 1165},
  year      = {2017},
  abstract  = {To study the role of the TTR-RBP4-ROH complex components (transthyretin, serum retinol binding protein, retinol) and of angiogenic factors PlGF (placental growth factor) and sFlt-1 (soluble fms-like tyrosine kinase-1) in pregnancies complicated by small for gestational age infants (SGA). Case control study conducted on maternal serum collected between 11 + 0 to 13 + 6 weeks of gestation. TTR, RBP4, ROH, PlGF and sFlt-1 were measured in SGA patients (birth weight < 10\%) who delivered at term (n = 37) and before 37 weeks of gestation (n = 17) and in a matched control group with uneventful pregnancies (n = 37). We found decreased RBP4 in SGA patients that delivered fetuses < 3\% and in fetuses delivered after the 37 weeks of gestation compared to controls [1.50 (95\% CI 1.40-1.75) vs 1.62 (95\% CI 1.47-1.98), p < 0.05]. Further, we found lower PlGF and sFlt-1 concentrations in SGA that delivered before 37 weeks of gestation compared to controls (respectively, PIGF and sFlt-1: 39.7 pg/ml (95\% CI 32.3-66.3) vs 62.9 pg/ml (95\% CI 45.2-78.4) and 906 pg/ml (95\% CI 727-1626) vs 1610 pg/ml (95\% CI 1088-212), p < 0.05). First trimester maternal serum RBP4 and angiogenic factors PlGF and sFlt-1 can differently predict the timing of delivery of pregnancies complicated by SGA fetuses.},
  language  = {en}
}
@phdthesis{Wu2017,
  author    = {Wu, Si},
  title     = {Exploring the Arabidopsis metabolic landscape by genetic mapping integrated with network analysis},
  school      = {Universit{\"a}t Potsdam},
  pages     = {121},
  year      = {2017},
  language  = {en}
}
@phdthesis{deAbreueLima2017,
  author    = {de Abreu e Lima, Francisco Anastacio},
  title     = {Experimental validation of hybrid performance predictive models in Zea mays L.},
  school      = {Universit{\"a}t Potsdam},
  pages     = {127},
  year      = {2017},
  language  = {en}
}
@phdthesis{Gorka2017,
  author    = {G{\´o}rka, Michal Jakub},
  title     = {Establishing a pipeline for identification of protein- protein interactions using different native fractionation methods},
  school      = {Universit{\"a}t Potsdam},
  pages     = {109},
  year      = {2017},
  language  = {en}
}
@article{NishinoOkamotoLeimkuehler2017,
  author    = {Nishino, Takeshi and Okamoto, Ken and Leimk{\"u}hler, Silke},
  title     = {Enzymes of the Xanthine Oxidase Family},
  series = {Molybdenum and tungsten enzymes : biochemistry},
  volume    = {5},
  journal   = {Molybdenum and tungsten enzymes : biochemistry},
  publisher = {Royal Society of Chemistry},
  address   = {Cambridge},
  isbn      = {978-1-78262-391-5},
  doi       = {10.1039/9781782623915-00192},
  pages     = {192 -- 239},
  year      = {2017},
  abstract  = {Enzymes from the xanthine oxidase (XO) family of molybdenum enzymes are generally, with some exceptions, molybdenum iron-sulfur flavin hydroxylases. Mammalian xanthine oxidoreductase and aldehyde oxidase were among the first enzymes to be studied in detail more than 100 years ago and, surprisingly, they continue to be thoroughly studied in molecular detail with many open and unresolved questions remaining. Enzymes of the XO family are characterized by a molybdenum cofactor (Moco) active site with a MoVIOS(OH) ligand sphere where substrate hydroxylation of either aromatic or aliphatic carbon centers is catalyzed. During the reaction, electrons are transferred to the oxidizing substrate, most commonly O2 or NAD+, which react at the FAD site.},
  language  = {en}
}
@article{BergholzMayGiladietal.2017,
  author    = {Bergholz, Kolja and May, Felix and Giladi, Itamar and Ristow, Michael and Ziv, Yaron and Jeltsch, Florian},
  title     = {Environmental heterogeneity drives fine-scale species assembly and functional diversity of annual plants in a semi-arid environment},
  series = {Perspectives in plant ecology, evolution and systematics},
  volume    = {24},
  journal   = {Perspectives in plant ecology, evolution and systematics},
  publisher = {Elsevier},
  address   = {Jena},
  issn      = {1433-8319},
  doi       = {10.1016/j.ppees.2017.01.001},
  pages     = {138 -- 146},
  year      = {2017},
  abstract  = {Spatial environmental heterogeneity is considered a fundamental factor for the maintenance of plant species richness. However, it still remains unclear whether heterogeneity may also facilitate coexistence at fine grain sizes or whether other processes, like mass effects and source sink dynamics due to dispersal, control species composition and diversity at these scales. In this study, we used two complimentary analyses to identify the role of heterogeneity within 15 m x 15 m plots for the coexistence of species-rich annual communities in a semi-arid environment along a steep precipitation gradient. Specifically, we: (a) analyzed the effect of environmental heterogeneity on species, functional and phylogenetic diversity within microsites (alpha diversity, 0.06 m(2) and 1 m(2)), across microsites (beta diversity), and diversity at the entire plot (gamma diversity); (b) further we used two null models to detect non-random trait and phylogenetic patterns in order to infer assembly processes, i.e. whether co-occurring species tend to share similar traits (trait convergence) or dissimilar traits (trait divergence). In general, our results showed that heterogeneity had a positive effect on community diversity. Specifically, for alpha diversity, the effect was significant for functional diversity, and not significant for either species or phylogenetic diversities. For beta diversity, all three measures of community diversity (species, functional, and phylogenetic) increased significantly, as they also did for gamma diversity, where functional measures were again stronger than for species or phylogenetic measures. In addition, the null model approach consistently detected trait convergence, indicating that species with similar traits tended to co-occur and had high abundances in a given microsite. While null model analysis across the phylogeny partly supported these trait findings, showing phylogenetic underdispersion at the 1m(2) grain size, surprisingly when species abundances in microsites were analyzed they were more evenly distributed across the phylogenetic tress than expected (phylogenetic overdispersion). In conclusion, our results provide compelling support that environmental heterogeneity at a relatively fine scale is an important factor for species co-existence as it positively affects diversity as well as influences species assembly. Our study underlines the need for trait-based approaches conducted at fine grain sizes in order to better understand species coexistence and community assembly. (C) 2017 Elsevier GmbH. All rights reserved.},
  language  = {en}
}
@article{HansenMeyerFerrarietal.2017,
  author    = {Hansen, Bjoern Oest and Meyer, Etienne H. and Ferrari, Camilla and Vaid, Neha and Movahedi, Sara and Vandepoele, Klaas and Nikoloski, Zoran and Mutwil, Marek},
  title     = {Ensemble gene function prediction database reveals genes important for complex I formation in Arabidopsis thaliana},
  series = {New phytologist : international journal of plant science},
  volume    = {217},
  journal   = {New phytologist : international journal of plant science},
  number    = {4},
  publisher = {Wiley},
  address   = {Hoboken},
  issn      = {0028-646X},
  doi       = {10.1111/nph.14921},
  pages     = {1521 -- 1534},
  year      = {2017},
  abstract  = {Recent advances in gene function prediction rely on ensemble approaches that integrate results from multiple inference methods to produce superior predictions. Yet, these developments remain largely unexplored in plants. We have explored and compared two methods to integrate 10 gene co-function networks for Arabidopsis thaliana and demonstrate how the integration of these networks produces more accurate gene function predictions for a larger fraction of genes with unknown function. These predictions were used to identify genes involved in mitochondrial complex I formation, and for five of them, we confirmed the predictions experimentally. The ensemble predictions are provided as a user-friendly online database, EnsembleNet. The methods presented here demonstrate that ensemble gene function prediction is a powerful method to boost prediction performance, whereas the EnsembleNet database provides a cutting-edge community tool to guide experimentalists.},
  language  = {en}
}
@article{WiegmannRutschmannWillemsen2017,
  author    = {Wiegmann, Alex and Rutschmann, Ronja and Willemsen, Pascale},
  title     = {Empirically investigating the concept of lying},
  series = {Journal of Indian Council of Philosophical Research},
  volume    = {34},
  journal   = {Journal of Indian Council of Philosophical Research},
  publisher = {Springer},
  address   = {New Dehli},
  issn      = {0970-7794},
  doi       = {10.1007/s40961-017-0112-z},
  pages     = {591 -- 609},
  year      = {2017},
  abstract  = {Lying is an everyday moral phenomenon about which philosophers have written a lot. Not only the moral status of lying has been intensively discussed but also what it means to lie in the first place. Perhaps the most important criterion for an adequate definition of lying is that it fits with people's understanding and use of this concept. In this light, it comes as a surprise that researchers only recently started to empirically investigate the folk concept of lying. In this paper, we describe three experimental studies which address the following questions: Does a statement need to be objectively false in order to constitute lying? Does lying necessarily include the intention to deceive? Can one lie by omitting relevant facts?},
  language  = {en}
}