@article{GrdseloffBouldayRoedeletal.2023, author = {Grdseloff, Nastasja and Boulday, Gwenola and Roedel, Claudia J. and Otten, Cecile and Vannier, Daphne Raphaelle and Cardoso, Cecile and Faurobert, Eva and Dogra, Deepika and Tournier-Lasserve, Elisabeth and Abdelilah-Seyfried, Salim}, title = {Impaired retinoic acid signaling in cerebral cavernous malformations}, series = {Scientific reports}, volume = {13}, journal = {Scientific reports}, number = {1}, publisher = {Nature Portfolio}, address = {Berlin}, issn = {2045-2322}, doi = {10.1038/s41598-023-31905-0}, pages = {11}, year = {2023}, abstract = {The capillary-venous pathology cerebral cavernous malformation (CCM) is caused by loss of CCM1/Krev interaction trapped protein 1 (KRIT1), CCM2/MGC4607, or CCM3/PDCD10 in some endothelial cells. Mutations of CCM genes within the brain vasculature can lead to recurrent cerebral hemorrhages. Pharmacological treatment options are urgently needed when lesions are located in deeply-seated and in-operable regions of the central nervous system. Previous pharmacological suppression screens in disease models of CCM led to the discovery that treatment with retinoic acid improved CCM phenotypes. This finding raised a need to investigate the involvement of retinoic acid in CCM and test whether it has a curative effect in preclinical mouse models. Here, we show that components of the retinoic acid synthesis and degradation pathway are transcriptionally misregulated across disease models of CCM. We complemented this analysis by pharmacologically modifying retinoic acid levels in zebrafish and human endothelial cell models of CCM, and in acute and chronic mouse models of CCM. Our pharmacological intervention studies in CCM2-depleted human umbilical vein endothelial cells (HUVECs) and krit1 mutant zebrafish showed positive effects when retinoic acid levels were increased. However, therapeutic approaches to prevent the development of vascular lesions in adult chronic murine models of CCM were drug regiment-sensitive, possibly due to adverse developmental effects of this hormone. A treatment with high doses of retinoic acid even worsened CCM lesions in an adult chronic murine model of CCM. This study provides evidence that retinoic acid signaling is impaired in the CCM pathophysiology and suggests that modification of retinoic acid levels can alleviate CCM phenotypes.}, language = {en} } @article{SmithBoers2023, author = {Smith, Taylor and Boers, Niklas}, title = {Global vegetation resilience linked to water availability and variability}, series = {Nature Communications}, volume = {14}, journal = {Nature Communications}, number = {1}, publisher = {Springer Nature}, address = {London}, issn = {2041-1723}, doi = {10.1038/s41467-023-36207-7}, pages = {11}, year = {2023}, abstract = {Quantifying the resilience of vegetated ecosystems is key to constraining both present-day and future global impacts of anthropogenic climate change. Here we apply both empirical and theoretical resilience metrics to remotely-sensed vegetation data in order to examine the role of water availability and variability in controlling vegetation resilience at the global scale. We find a concise global relationship where vegetation resilience is greater in regions with higher water availability. We also reveal that resilience is lower in regions with more pronounced inter-annual precipitation variability, but find less concise relationships between vegetation resilience and intra-annual precipitation variability. Our results thus imply that the resilience of vegetation responds differently to water deficits at varying time scales. In view of projected increases in precipitation variability, our findings highlight the risk of ecosystem degradation under ongoing climate change. Vegetation dynamics depend on both the amount of precipitation and its variability over time. Here, the authors show that vegetation resilience is greater where water availability is higher and where precipitation is more stable from year to year.}, language = {en} } @article{FalkenhagenKnoechelKloftetal.2023, author = {Falkenhagen, Undine and Kn{\"o}chel, Jane and Kloft, Charlotte and Huisinga, Wilhelm}, title = {Deriving mechanism-based pharmacodynamic models by reducing quantitative systems pharmacology models}, series = {CPT: Pharmacometrics \& Systems Pharmacology}, volume = {12}, journal = {CPT: Pharmacometrics \& Systems Pharmacology}, number = {4}, publisher = {Wiley}, address = {Hoboken}, issn = {2163-8306}, doi = {10.1002/psp4.12903}, pages = {432 -- 443}, year = {2023}, abstract = {Quantitative systems pharmacology (QSP) models integrate comprehensive qualitative and quantitative knowledge about pharmacologically relevant processes. We previously proposed a first approach to leverage the knowledge in QSP models to derive simpler, mechanism-based pharmacodynamic (PD) models. Their complexity, however, is typically still too large to be used in the population analysis of clinical data. Here, we extend the approach beyond state reduction to also include the simplification of reaction rates, elimination of reactions, and analytic solutions. We additionally ensure that the reduced model maintains a prespecified approximation quality not only for a reference individual but also for a diverse virtual population. We illustrate the extended approach for the warfarin effect on blood coagulation. Using the model-reduction approach, we derive a novel small-scale warfarin/international normalized ratio model and demonstrate its suitability for biomarker identification. Due to the systematic nature of the approach in comparison with empirical model building, the proposed model-reduction algorithm provides an improved rationale to build PD models also from QSP models in other applications.}, language = {en} } @article{LewkowiczBoettingerSiegel2023, author = {Lewkowicz, Daniel and B{\"o}ttinger, Erwin and Siegel, Martin}, title = {Economic evaluation of digital therapeutic care apps for unsupervised treatment of low back pain}, series = {JMIR mhealth and uhealth}, volume = {11}, journal = {JMIR mhealth and uhealth}, publisher = {JMIR Publications}, address = {Toronto}, issn = {2291-5222}, doi = {10.2196/44585}, pages = {14}, year = {2023}, abstract = {Background: Digital therapeutic care (DTC) programs are unsupervised app-based treatments that provide video exercises and educational material to patients with nonspecific low back pain during episodes of pain and functional disability. German statutory health insurance can reimburse DTC programs since 2019, but evidence on efficacy and reasonable pricing remains scarce. This paper presents a probabilistic sensitivity analysis (PSA) to evaluate the efficacy and cost-utility of a DTC app against treatment as usual (TAU) in Germany. Objective: The aim of this study was to perform a PSA in the form of a Monte Carlo simulation based on the deterministic base case analysis to account for model assumptions and parameter uncertainty. We also intend to explore to what extent the results in this probabilistic analysis differ from the results in the base case analysis and to what extent a shortage of outcome data concerning quality-of-life (QoL) metrics impacts the overall results. Methods: The PSA builds upon a state-transition Markov chain with a 4-week cycle length over a model time horizon of 3 years from a recently published deterministic cost-utility analysis. A Monte Carlo simulation with 10,000 iterations and a cohort size of 10,000 was employed to evaluate the cost-utility from a societal perspective. Quality-adjusted life years (QALYs) were derived from Veterans RAND 6-Dimension (VR-6D) and Short-Form 6-Dimension (SF-6D) single utility scores. Finally, we also simulated reducing the price for a 3-month app prescription to analyze at which price threshold DTC would result in being the dominant strategy over TAU in Germany. Results: The Monte Carlo simulation yielded on average a euro135.97 (a currency exchange rate of EUR euro1=US \$1.069 is applicable) incremental cost and 0.004 incremental QALYs per person and year for the unsupervised DTC app strategy compared to in-person physiotherapy in Germany. The corresponding incremental cost-utility ratio (ICUR) amounts to an additional euro34,315.19 per additional QALY. DTC yielded more QALYs in 54.96\% of the iterations. DTC dominates TAU in 24.04\% of the iterations for QALYs. Reducing the app price in the simulation from currently euro239.96 to euro164.61 for a 3-month prescription could yield a negative ICUR and thus make DTC the dominant strategy, even though the estimated probability of DTC being more effective than TAU is only 54.96\%. Conclusions: Decision-makers should be cautious when considering the reimbursement of DTC apps since no significant treatment effect was found, and the probability of cost-effectiveness remains below 60\% even for an infinite willingness-to-pay threshold. More app-based studies involving the utilization of QoL outcome parameters are urgently needed to account for the low and limited precision of the available QoL input parameters, which are crucial to making profound recommendations concerning the cost-utility of novel apps.}, language = {en} } @article{KapidzicFreyNeubergeretal.2023, author = {Kapidzic, Sanja and Frey, Felix and Neuberger, Christoph and Stieglitz, Stefan and Mirbabaie, Milad}, title = {Crisis communication on Twitter}, series = {International journal of communication}, volume = {17}, journal = {International journal of communication}, publisher = {The Annenberg Center for Communication}, address = {Los Angeles, Calif.}, issn = {1932-8036}, pages = {735 -- 754}, year = {2023}, abstract = {The study explores differences between three user types in the top tweets about the 2015 "refugee crisis" in Germany and presents the results of a quantitative content analysis. All tweets with the keyword "Fl{\"u}chtlinge" posted for a monthlong period following September 13, 2015, the day Germany decided to implement border controls, were collected (N = 763,752). The top 2,495 tweets according to number of retweets were selected for analysis. Differences between news media, public and private actor tweets in topics, tweet characteristics such as tone and opinion expression, links, and specific sentiments toward refugees were analyzed. We found strong differences between the tweets. Public actor tweets were the main source of positive sentiment toward refugees and the main information source on refugee support. News media tweets mostly reflected traditional journalistic norms of impartiality and objectivity, whereas private actor tweets were more diverse in sentiments toward refugees.}, language = {en} } @article{AgtheKayserSchwarzetal.2023, author = {Agthe, Maria and Kayser, Daniela Niesta and Schwarz, Sascha and Maner, Jon K.}, title = {Antecedents of the red-romance effect}, series = {PLOS ONE / Public Library of Science}, volume = {18}, journal = {PLOS ONE / Public Library of Science}, number = {4}, publisher = {PLOS}, address = {San Fransisco}, issn = {1932-6203}, doi = {10.1371/journal.pone.0284035}, pages = {19}, year = {2023}, abstract = {The color red has been implicated in a variety of social processes, including those involving mating. While previous research suggests that women sometimes wear red strategically to increase their attractiveness, the replicability of this literature has been questioned. The current research is a reasonably powered conceptual replication designed to strengthen this literature by testing whether women are more inclined to display the color red 1) during fertile (as compared with less fertile) days of the menstrual cycle, and 2) when expecting to interact with an attractive man (as compared with a less attractive man and with a control condition). Analyses controlled for a number of theoretically relevant covariates (relationship status, age, the current weather). Only the latter hypothesis received mixed support (mainly among women on hormonal birth control), whereas results concerning the former hypothesis did not reach significance. Women (N = 281) displayed more red when expecting to interact with an attractive man; findings did not support the prediction that women would increase their display of red on fertile days of the cycle. Findings thus suggested only mixed replicability for the link between the color red and psychological processes involving romantic attraction. They also illustrate the importance of further investigating the boundary conditions of color effects on everyday social processes.}, language = {en} } @article{SchmickerFruehlingMenzeetal.2023, author = {Schmicker, Marlen and Fr{\"u}hling, Insa and Menze, Inga and Glanz, Wenzel and M{\"u}ller, Patrick and Noesselt, Toemme and M{\"u}ller, Notger Germar}, title = {The potential role of gustatory function as an early diagnostic marker for the risk of alzheimer's disease in subjective cognitive decline}, series = {Journal of Alzheimer's disease reports : JADR}, volume = {7}, journal = {Journal of Alzheimer's disease reports : JADR}, number = {1}, publisher = {IOS Press}, address = {Clifton, VA}, issn = {2542-4823}, doi = {10.3233/ADR220092}, pages = {249 -- 262}, year = {2023}, abstract = {Background: Patients with subjective cognitive decline (SCD) report memory deterioration and are at an increased risk of converting to Alzheimer's disease (AD) although psychophysical testing does not reveal any cognitive deficit. Objective: Here, gustatory function is investigated as a potential predictor for an increased risk of progressive cognitive decline indicating higher AD risk in SCD. Methods: Measures of smell and taste perception as well as neuropsychological data were assessed in patients with subjective cognitive decline (SCD): Subgroups with an increased likelihood of the progression to preclinical AD (SCD+) and those with a lower likelihood (SCD-) were compared to healthy controls (HC), patients with mild cognitive impairment and AD patients. The Sniffin' Sticks test contained 12 items with different qualities and taste was measured with 32 taste stripes (sweet, salty, bitter, sour) of different concentration. Results: Only taste was able to distinguish between HC/SCD- and SCD+ patients. Conclusion: This study provides a first hint of taste as a more sensitive marker than smell for detecting preclinical AD in SCD. Longitudinal observation of cognition and pathology are necessary to further evaluate taste perception as a predictor of pathological objective decline in cognition.}, language = {en} } @article{deCarvalhoSouzaBarrocasFischeretal.2023, author = {de Carvalho Souza, Alyson Matheus and Barrocas, Roberta and Fischer, Martin H. and Arnaud, Emanuel and Moeller, Korbinian and Renn{\´o}-Costa, C{\´e}sar}, title = {Combining virtual reality and tactile stimulation to investigate embodied finger-based numerical representations}, series = {Frontiers in psychology / Frontiers Research Foundation}, volume = {14}, journal = {Frontiers in psychology / Frontiers Research Foundation}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1664-1078}, doi = {10.3389/fpsyg.2023.1119561}, pages = {13}, year = {2023}, abstract = {Finger-based representation of numbers is a high-level cognitive strategy to assist numerical and arithmetic processing in children and adults. It is unclear whether this paradigm builds on simple perceptual features or comprises several attributes through embodiment. Here we describe the development and initial testing of an experimental setup to study embodiment during a finger-based numerical task using Virtual Reality (VR) and a low-cost tactile stimulator that is easy to build. Using VR allows us to create new ways to study finger-based numerical representation using a virtual hand that can be manipulated in ways our hand cannot, such as decoupling tactile and visual stimuli. The goal is to present a new methodology that can allow researchers to study embodiment through this new approach, maybe shedding new light on the cognitive strategy behind the finger-based representation of numbers. In this case, a critical methodological requirement is delivering precisely targeted sensory stimuli to specific effectors while simultaneously recording their behavior and engaging the participant in a simulated experience. We tested the device's capability by stimulating users in different experimental configurations. Results indicate that our device delivers reliable tactile stimulation to all fingers of a participant's hand without losing motion tracking quality during an ongoing task. This is reflected by an accuracy of over 95\% in participants detecting stimulation of a single finger or multiple fingers in sequential stimulation as indicated by experiments with sixteen participants. We discuss possible application scenarios, explain how to apply our methodology to study the embodiment of finger-based numerical representations and other high-level cognitive functions, and discuss potential further developments of the device based on the data obtained in our testing.}, language = {en} } @article{StueblerKloftHuisinga2023, author = {St{\"u}bler, Sabine and Kloft, Charlotte and Huisinga, Wilhelm}, title = {Cell-level systems biology model to study inflammatory bowel diseases and their treatment options}, series = {CPT: pharmacometrics \& systems pharmacology}, volume = {12}, journal = {CPT: pharmacometrics \& systems pharmacology}, number = {5}, publisher = {Nature Publ. Group}, address = {London}, issn = {2163-8306}, doi = {10.1002/psp4.12932}, pages = {690 -- 705}, year = {2023}, abstract = {To help understand the complex and therapeutically challenging inflammatory bowel diseases (IBDs), we developed a systems biology model of the intestinal immune system that is able to describe main aspects of IBD and different treatment modalities thereof. The model, including key cell types and processes of the mucosal immune response, compiles a large amount of isolated experimental findings from literature into a larger context and allows for simulations of different inflammation scenarios based on the underlying data and assumptions. In the context of a large and diverse virtual IBD population, we characterized the patients based on their phenotype (in contrast to healthy individuals, they developed persistent inflammation after a trigger event) rather than on a priori assumptions on parameter differences to a healthy individual. This allowed to reproduce the enormous diversity of predispositions known to lead to IBD. Analyzing different treatment effects, the model provides insight into characteristics of individual drug therapy. We illustrate for anti-TNF-alpha therapy, how the model can be used (i) to decide for alternative treatments with best prospects in the case of nonresponse, and (ii) to identify promising combination therapies with other available treatment options.}, language = {en} } @article{EhrigWagnerWolteretal.2023, author = {Ehrig, Lukas and Wagner, Ann-Christin and Wolter, Heike and Correll, Christoph U. and Geisel, Olga and Konigorski, Stefan}, title = {FASDetect as a machine learning-based screening app for FASD in youth with ADHD}, series = {npj Digital Medicine}, volume = {6}, journal = {npj Digital Medicine}, number = {1}, publisher = {Macmillan Publishers Limited}, address = {Basingstoke}, issn = {2398-6352}, doi = {10.1038/s41746-023-00864-1}, pages = {9}, year = {2023}, abstract = {Fetal alcohol-spectrum disorder (FASD) is underdiagnosed and often misdiagnosed as attention-deficit/hyperactivity disorder (ADHD). Here, we develop a screening tool for FASD in youth with ADHD symptoms. To develop the prediction model, medical record data from a German University outpatient unit are assessed including 275 patients aged 0-19 years old with FASD with or without ADHD and 170 patients with ADHD without FASD aged 0-19 years old. We train 6 machine learning models based on 13 selected variables and evaluate their performance. Random forest models yield the best prediction models with a cross-validated AUC of 0.92 (95\% confidence interval [0.84, 0.99]). Follow-up analyses indicate that a random forest model with 6 variables - body length and head circumference at birth, IQ, socially intrusive behaviour, poor memory and sleep disturbance - yields equivalent predictive accuracy. We implement the prediction model in a web-based app called FASDetect - a user-friendly, clinically scalable FASD risk calculator that is freely available at https://fasdetect.dhc-lab.hpi.de.}, language = {en} } @article{SlosarekIbingSchormairetal.2023, author = {Slosarek, Tamara and Ibing, Susanne and Schormair, Barbara and Heyne, Henrike and B{\"o}ttinger, Erwin and Andlauer, Till and Schurmann, Claudia}, title = {Implementation and evaluation of personal genetic testing as part of genomics analysis courses in German universities}, series = {BMC Medical Genomics}, volume = {16}, journal = {BMC Medical Genomics}, number = {1}, publisher = {BMC}, address = {London}, issn = {1755-8794}, doi = {10.1186/s12920-023-01503-0}, pages = {13}, year = {2023}, abstract = {Purpose Due to the increasing application of genome analysis and interpretation in medical disciplines, professionals require adequate education. Here, we present the implementation of personal genotyping as an educational tool in two genomics courses targeting Digital Health students at the Hasso Plattner Institute (HPI) and medical students at the Technical University of Munich (TUM). Methods We compared and evaluated the courses and the students ' perceptions on the course setup using questionnaires. Results During the course, students changed their attitudes towards genotyping (HPI: 79\% [15 of 19], TUM: 47\% [25 of 53]). Predominantly, students became more critical of personal genotyping (HPI: 73\% [11 of 15], TUM: 72\% [18 of 25]) and most students stated that genetic analyses should not be allowed without genetic counseling (HPI: 79\% [15 of 19], TUM: 70\% [37 of 53]). Students found the personal genotyping component useful (HPI: 89\% [17 of 19], TUM: 92\% [49 of 53]) and recommended its inclusion in future courses (HPI: 95\% [18 of 19], TUM: 98\% [52 of 53]). Conclusion Students perceived the personal genotyping component as valuable in the described genomics courses. The implementation described here can serve as an example for future courses in Europe.}, language = {en} } @article{TiberiusWeyland2023, author = {Tiberius, Victor and Weyland, Michael}, title = {Identifying constituent elements of entrepreneurship curricula}, series = {Administrative sciences}, volume = {14}, journal = {Administrative sciences}, number = {1}, publisher = {MDPI}, address = {Basel}, issn = {2076-3387}, doi = {10.3390/admsci14010001}, pages = {18}, year = {2023}, abstract = {Entrepreneurship education research has a strong "output" focus on impact studies but pays much less attention to the "inside" or process perspective of the way entrepreneurship education occurs. In particular, the scattered previous entrepreneurship curriculum research has not managed to provide a current and comprehensive overview of the curricular elements that constitute entrepreneurship education. To overcome this shortcoming, we aim to identify the teaching objectives, teaching contents, teaching methods, and assessment methods discussed in entrepreneurship curriculum research. To this end, we conducted a systematic literature review on the four entrepreneurship curriculum dimensions and collected all mentioned curriculum items. We used a two-stage coding procedure to find the genuinely entrepreneurship-specific items. Among numerous items (also from business management and other subjects), we found 26 objectives, 34 contents, 11 teaching methods, and 7 assessment methods that were entrepreneurship-specific. Most of these items were addressed by only a few scholarly papers.}, language = {en} } @article{BoschDeCesareDemskeetal.2023, author = {Bosch, Sina and De Cesare, Ilaria and Demske, Ulrike and Felser, Claudia}, title = {Word-order variation and coherence in German infinitival complementation}, series = {The journal of comparative Germanic linguistics}, volume = {26}, journal = {The journal of comparative Germanic linguistics}, number = {1}, publisher = {Springer}, address = {New York}, issn = {1572-8552}, doi = {10.1007/s10828-023-09140-8}, pages = {43}, year = {2023}, abstract = {This study provides a synthesis of corpus-based and experimental investigations of word-order preferences in German infinitival complementation. We carried out a systematic analysis of present-day German corpora to establish frequency distributions of different word-order options: extraposition, intraposition, and 'third construction'. We then examined, firstly, whether and to what extent corpus frequencies and processing economy constraints can predict the acceptability of these three word-order variants, and whether subject raising and subject control verbs form clearly distinguishable subclasses of infinitive-embedding verbs in terms of their word-order behaviour. Secondly, our study looks into the issue of coherence by comparing acceptability ratings for monoclausal coherent and biclausal incoherent construals of intraposed infinitives, and by examining whether a biclausal incoherent analysis gives rise to local and/or global processing difficulty. Taken together, our results revealed that (i) whilst the extraposition pattern consistently wins out over all other word-order variants for control verbs, neither frequency nor processing-based approaches to word-order variation can account for the acceptability of low-frequency variants, (ii) there is considerable verb-specific variation regarding word-order preferences both between and within the two sets of raising and control verbs under investigation, and (iii) although monoclausal coherent intraposition is rated above biclausal incoherent intraposition, the latter is not any more difficult to process than the former. Our findings indicate that frequency of occurrence and processing-related constraints interact with idiosyncratic lexical properties of individual verbs in determining German speakers' structural preferences.}, language = {en} } @article{SchellWardelmannHauffeetal.2023, author = {Schell, Mareike and Wardelmann, Kristina and Hauffe, Robert and Rath, Michaela and Chopra, Simran and Kleinridders, Andr{\´e}}, title = {Lactobacillus rhamnosus sex-specifically attenuates depressive-like behavior and mitigates metabolic consequences in obesity}, series = {Biological psychiatry: global open science}, volume = {3}, journal = {Biological psychiatry: global open science}, number = {4}, publisher = {Elsevier}, address = {Amsterdam}, issn = {2667-1743}, doi = {10.1016/j.bpsgos.2023.02.011}, pages = {651 -- 662}, year = {2023}, abstract = {BACKGROUND: Patients with diabetes exhibit an increased prevalence for emotional disorders compared with healthy humans, partially due to a shared pathogenesis including hormone resistance and inflammation, which is also linked to intestinal dysbiosis. The preventive intake of probiotic lactobacilli has been shown to improve dysbiosis along with mood and metabolism. Yet, a potential role of Lactobacillus rhamnosus (Lacticaseibacillus rhamnosus 0030) (LR) in improving emotional behavior in established obesity and the underlying mechanisms are unknown. METHODS: Female and male C57BL/6N mice were fed a low-fat diet (10\% kcal from fat) or high-fat diet (HFD) (45\% kcal from fat) for 6 weeks, followed by daily oral gavage of vehicle or 1 3 10 8 colony-forming units of LR, and assessment of anxiety- and depressive-like behavior. Cecal microbiota composition was analyzed using 16S ribosomal RNA sequencing, plasma and cerebrospinal fluid were collected for metabolomic analysis, and gene expression of different brain areas was assessed using reverse transcriptase quantitative polymerase chain reaction. RESULTS: We observed that 12 weeks of HFD feeding induced hyperinsulinemia, which was attenuated by LR application only in female mice. On the contrary, HFD-fed male mice exhibited increased anxiety- and depressive-like behavior, where the latter was specifically attenuated by LR application, which was independent of metabolic changes. Furthermore, LR application restored the HFD-induced decrease of tyrosine hydroxylase, along with normalizing cholecystokinin gene expression in dopaminergic brain regions; both tyrosine hydroxylase and cholecystokinin are involved in signaling pathways impacting emotional disorders. CONCLUSIONS: Our data show that LR attenuates depressive-like behavior after established obesity, with changes in the dopaminergic system in male mice, and mitigates hyperinsulinemia in obese female mice.}, language = {en} } @article{SixtusLindnerLohseetal.2023, author = {Sixtus, Elena and Lindner, Nadja and Lohse, Karoline and Lonnemann, Jan}, title = {Investigating the influence of body movements on children's mental arithmetic performance}, series = {Acta psychologica : international journal of psychonomics}, volume = {239}, journal = {Acta psychologica : international journal of psychonomics}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0001-6918}, doi = {10.1016/j.actpsy.2023.104003}, pages = {7}, year = {2023}, abstract = {Several lines of research have demonstrated spatial-numerical associations in both adults and children, which are thought to be based on a spatial representation of numerical information in the form of a mental number line. The acquisition of increasingly precise mental number line representations is assumed to support arithmetic learning in children. It is further suggested that sensorimotor experiences shape the development of number concepts and arithmetic learning, and that mental arithmetic can be characterized as "motion along a path" and might constitute shifts in attention along the mental number line. The present study investigated whether movements in physical space influence mental arithmetic in primary school children, and whether the expected effect depends on concurrency of body movements and mental arithmetic. After turning their body towards the left or right, 48 children aged 8 to 10 years solved simple subtraction and addition problems. Meanwhile, they either walked or stood still and looked towards the respective direction. We report a congruency effect between body orientation and operation type, i.e., higher performance for the combinations leftward orientation and subtraction and rightward orientation and addition. We found no significant difference between walking and looking conditions. The present results suggest that mental arithmetic in children is influenced by preceding sensorimotor cues and not necessarily by concurrent body movements.}, language = {en} } @article{HeideNetzebandtAhrensetal.2023, author = {Heide, Judith and Netzebandt, Jonka and Ahrens, Stine and Br{\"u}sch, Julia and Saalfrank, Teresa and Schmitz-Antonischki, Dorit}, title = {Improving lexical retrieval with LingoTalk}, series = {Frontiers in communication}, volume = {8}, journal = {Frontiers in communication}, publisher = {Frontiers Media}, address = {Lausanne}, issn = {2297-900X}, doi = {10.3389/fcomm.2023.1210193}, pages = {16}, year = {2023}, abstract = {Introduction LingoTalk is a German speech-language app designed to enhance lexical retrieval in individuals with aphasia. It incorporates automatic speech recognition (ASR) to provide therapist-independent feedback. The execution and effectiveness of a self-administered intervention with LingoTalk was explored in a case series study. Methods Three individuals with chronic aphasia participated in a highly individualized, supervised self-administered intervention lasting 3 weeks. The LingoTalk app closely monitored the frequency, intensity and progress of the intervention. Treatment efficacy was assessed using a multiple baseline design, examining both item-specific treatment effects and generalization to untreated items, an untreated task, and spontaneous speech. Results All participants successfully completed the intervention with LingoTalk, although one participant was not able to use the ASR feature. None of the participants fully adhered to the treatment protocol. All participants demonstrated significant and sustained improvement in the naming of practiced items, although there was limited evidence of generalization. Additionally, there was a slight reduction in word-finding difficulties during spontaneous speech. Discussion This small-scale study indicates that self-administered intervention with LingoTalk can improve oral naming of treated items. Thus, it has the potential to complement face-to-face speech-language therapy, such as within in a "flipped speech room" approach. The choice of feedback mode is discussed. Transparent progress monitoring of the intervention appears to positively influence patients' motivation.}, language = {en} } @article{RosenblumPikovsky2023, author = {Rosenblum, Michael and Pikovsky, Arkady}, title = {Inferring connectivity of an oscillatory network via the phase dynamics reconstruction}, series = {Frontiers in network physiology}, volume = {3}, journal = {Frontiers in network physiology}, publisher = {Frontiers Media}, address = {Lausanne}, issn = {2674-0109}, doi = {10.3389/fnetp.2023.1298228}, pages = {10}, year = {2023}, abstract = {We review an approach for reconstructing oscillatory networks' undirected and directed connectivity from data. The technique relies on inferring the phase dynamics model. The central assumption is that we observe the outputs of all network nodes. We distinguish between two cases. In the first one, the observed signals represent smooth oscillations, while in the second one, the data are pulse-like and can be viewed as point processes. For the first case, we discuss estimating the true phase from a scalar signal, exploiting the protophase-to-phase transformation. With the phases at hand, pairwise and triplet synchronization indices can characterize the undirected connectivity. Next, we demonstrate how to infer the general form of the coupling functions for two or three oscillators and how to use these functions to quantify the directional links. We proceed with a different treatment of networks with more than three nodes. We discuss the difference between the structural and effective phase connectivity that emerges due to high-order terms in the coupling functions. For the second case of point-process data, we use the instants of spikes to infer the phase dynamics model in the Winfree form directly. This way, we obtain the network's coupling matrix in the first approximation in the coupling strength.}, language = {en} } @article{KonakvandeWaterDoeringetal.2023, author = {Konak, Orhan and van de Water, Robin and D{\"o}ring, Valentin and Fiedler, Tobias and Liebe, Lucas and Masopust, Leander and Postnov, Kirill and Sauerwald, Franz and Treykorn, Felix and Wischmann, Alexander and Gjoreski, Hristijan and Luštrek, Mitja and Arnrich, Bert}, title = {HARE}, series = {Sensors}, volume = {23}, journal = {Sensors}, number = {23}, publisher = {MDPI}, address = {Basel}, issn = {1424-8220}, doi = {10.3390/s23239571}, pages = {23}, year = {2023}, abstract = {Sensor-based human activity recognition is becoming ever more prevalent. The increasing importance of distinguishing human movements, particularly in healthcare, coincides with the advent of increasingly compact sensors. A complex sequence of individual steps currently characterizes the activity recognition pipeline. It involves separate data collection, preparation, and processing steps, resulting in a heterogeneous and fragmented process. To address these challenges, we present a comprehensive framework, HARE, which seamlessly integrates all necessary steps. HARE offers synchronized data collection and labeling, integrated pose estimation for data anonymization, a multimodal classification approach, and a novel method for determining optimal sensor placement to enhance classification results. Additionally, our framework incorporates real-time activity recognition with on-device model adaptation capabilities. To validate the effectiveness of our framework, we conducted extensive evaluations using diverse datasets, including our own collected dataset focusing on nursing activities. Our results show that HARE's multimodal and on-device trained model outperforms conventional single-modal and offline variants. Furthermore, our vision-based approach for optimal sensor placement yields comparable results to the trained model. Our work advances the field of sensor-based human activity recognition by introducing a comprehensive framework that streamlines data collection and classification while offering a novel method for determining optimal sensor placement.}, language = {en} } @article{BlaserWeymarWendt2023, author = {Blaser, Berenike Lisa and Weymar, Mathias and Wendt, Julia}, title = {The effect of a single-session heart rate variability biofeedback on attentional control}, series = {Frontiers in psychology}, volume = {14}, journal = {Frontiers in psychology}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1664-1078}, doi = {10.3389/fpsyg.2023.1292983}, pages = {13}, year = {2023}, abstract = {Introduction Vagally mediated heart rate variability is an index of autonomic nervous system activity that is associated with a large variety of outcome variables including psychopathology and self-regulation. While practicing heart rate variability biofeedback over several weeks has been reliably associated with a number of positive outcomes, its acute effects are not well known. As the strongest association with vagally mediated heart rate variability has been found particularly within the attention-related subdomain of self-regulation, we investigated the acute effect of heart rate variability biofeedback on attentional control using the revised Attention Network Test. Methods Fifty-six participants were tested in two sessions. In one session each participant received a heart rate variability biofeedback intervention, and in the other session a control intervention of paced breathing at a normal ventilation rate. After the biofeedback or control intervention, participants completed the Attention Network Test using the Orienting Score as a measure of attentional control. Results Mixed models revealed that higher resting baseline vagally mediated heart rate variability was associated with better performance in attentional control, which suggests more efficient direction of attention to target stimuli. There was no significant main effect of the intervention on attentional control. However, an interaction effect indicated better performance in attentional control after biofeedback in individuals who reported higher current stress levels. Discussion The results point to acute beneficial effects of heart rate variability biofeedback on cognitive performance in highly stressed individuals. Although promising, the results need to be replicated in larger or more targeted samples in order to reach stronger conclusions about the effects.}, language = {en} } @article{LangaryKuekenNikoloski2023, author = {Langary, Damoun and K{\"u}ken, Anika and Nikoloski, Zoran}, title = {The effective deficiency of biochemical networks}, series = {Scientific reports}, volume = {13}, journal = {Scientific reports}, publisher = {Springer Nature}, address = {London}, issn = {2045-2322}, doi = {10.1038/s41598-023-41767-1}, pages = {12}, year = {2023}, abstract = {The deficiency of a (bio)chemical reaction network can be conceptually interpreted as a measure of its ability to support exotic dynamical behavior and/or multistationarity. The classical definition of deficiency relates to the capacity of a network to permit variations of the complex formation rate vector at steady state, irrespective of the network kinetics. However, the deficiency is by definition completely insensitive to the fine details of the directionality of reactions as well as bounds on reaction fluxes. While the classical definition of deficiency can be readily applied in the analysis of unconstrained, weakly reversible networks, it only provides an upper bound in the cases where relevant constraints on reaction fluxes are imposed. Here we propose the concept of effective deficiency, which provides a more accurate assessment of the network's capacity to permit steady state variations at the complex level for constrained networks of any reversibility patterns. The effective deficiency relies on the concept of nonstoichiometric balanced complexes, which we have already shown to be present in real-world biochemical networks operating under flux constraints. Our results demonstrate that the effective deficiency of real-world biochemical networks is smaller than the classical deficiency, indicating the effects of reaction directionality and flux bounds on the variation of the complex formation rate vector at steady state.}, language = {en} } @article{SammoudBouguezziUthoffetal.2023, author = {Sammoud, Senda and Bouguezzi, Raja and Uthoff, Aaron and Ramirez-Campillo, Rodrigo and Moran, Jason and Negra, Yassine and Hachana, Younes and Chaabene, Helmi}, title = {The effects of backward vs. forward running training on measures of physical fitness in young female handball players}, series = {Frontiers in sports and active living}, volume = {5}, journal = {Frontiers in sports and active living}, publisher = {Frontiers Media}, address = {Lausanne}, issn = {2624-9367}, doi = {10.3389/fspor.2023.1244369}, pages = {10}, year = {2023}, abstract = {Introduction This study examined the effects of an 8-week backward running (BR) vs. forward running (FR) training programmes on measures of physical fitness in young female handball players. Methods Twenty-nine players participated in this study. Participants were randomly assigned to a FR training group, BR training group, and a control group. Results and discussion Within-group analysis indicated significant, small-to-large improvements in all performance tests (effect size [g] = 0.36 to 1.80), except 5-m forward sprint-time in the BR group and 5- and 10-m forward sprint-time in the FR group. However, the CG significantly decreased forward sprint performance over 10-m and 20-m (g = 0.28 to 0.50) with no changes in the other fitness parameters. No significant differences in the amount of change scores between the BR and FR groups were noted. Both training interventions have led to similar improvements in measures of muscle power, change of direction (CoD) speed, sprint speed either forward or backward, and repeated sprint ability (RSA) in young female handball players, though BR training may have a small advantage over FR training for 10-m forward sprint time and CoD speed, while FR training may provide small improvements over BR training for RSAbest. Practitioners are advised to consider either FR or BR training to improve various measures of physical fitness in young female handball players.}, language = {en} } @article{QuarmbyZhangGeisleretal.2023, author = {Quarmby, Andrew and Zhang, Martin and Geisler, Moritz and Javorsky, Tomas and Mugele, Hendrik and Cassel, Michael and Lawley, Justin}, title = {Risk factors and injury prevention strategies for overuse injuries in adult climbers}, series = {Frontiers in sports and active living}, volume = {5}, journal = {Frontiers in sports and active living}, publisher = {Frontiers Media}, address = {Lausanne}, issn = {2624-9367}, doi = {10.3389/fspor.2023.1269870}, pages = {13}, year = {2023}, abstract = {Introduction Climbing is an increasingly popular activity and imposes specific physiological demands on the human body, which results in unique injury presentations. Of particular concern are overuse injuries (non-traumatic injuries). These injuries tend to present in the upper body and might be preventable with adequate knowledge of risk factors which could inform about injury prevention strategies. Research in this area has recently emerged but has yet to be synthesized comprehensively. Therefore, the aim of this study was to conduct a systematic review of the potential risk factors and injury prevention strategies for overuse injuries in adult climbers. Methods This systematic review was conducted in accordance with the PRISMA guidelines. Databases were searched systematically, and articles were deemed eligible based upon specific criteria. Research included was original and peer-reviewed, involving climbers, and published in English, German or Czech. Outcomes included overuse injury, and at least one or more variable indicating potential risk factors or injury prevention strategies. The methodological quality of the included studies was assessed with the Downs and Black Quality Index. Data were extracted from included studies and reported descriptively for population, climbing sport type, study design, injury definition and incidence/prevalence, risk factors, and injury prevention strategies. Results Out of 1,183 records, a total of 34 studies were included in the final analysis. Higher climbing intensity, bouldering, reduced grip/finger strength, use of a "crimp" grip, and previous injury were associated with an increased risk of overuse injury. Additionally, a strength training intervention prevented shoulder and elbow injuries. BMI/body weight, warm up/cool downs, stretching, taping and hydration were not associated with risk of overuse injury. The evidence for the risk factors of training volume, age/years of climbing experience, and sex was conflicting. Discussion This review presents several risk factors which appear to increase the risk of overuse injury in climbers. Strength and conditioning, load management, and climbing technique could be targeted in injury prevention programs, to enhance the health and wellbeing of climbing athletes. Further research is required to investigate the conflicting findings reported across included studies, and to investigate the effectiveness of injury prevention programs. Systematic Review Registrationhttps://www.crd.york.ac.uk/, PROSPERO (CRD42023404031).}, language = {en} } @article{BuergerHeistermann2023, author = {B{\"u}rger, Gerd and Heistermann, Maik}, title = {Shallow and deep learning of extreme rainfall events from convective atmospheres}, series = {Natural hazards and earth system sciences : NHESS}, volume = {23}, journal = {Natural hazards and earth system sciences : NHESS}, number = {9}, publisher = {European Geophysical Society}, address = {Katlenburg-Lindau}, issn = {1561-8633}, doi = {10.5194/nhess-23-3065-2023}, pages = {3065 -- 3077}, year = {2023}, abstract = {Our subject is a new catalogue of radar-based heavy rainfall events (CatRaRE) over Germany and how it relates to the concurrent atmospheric circulation. We classify daily ERA5 fields of convective indices according to CatRaRE, using an array of 13 statistical methods, consisting of 4 conventional ("shallow") and 9 more recent deep machine learning (DL) algorithms; the classifiers are then applied to corresponding fields of simulated present and future atmospheres from the Coordinated Regional Climate Downscaling Experiment (CORDEX) project. The inherent uncertainty of the DL results from the stochastic nature of their optimization is addressed by employing an ensemble approach using 20 runs for each network. The shallow random forest method performs best with an equitable threat score (ETS) around 0.52, followed by the DL networks ALL-CNN and ResNet with an ETS near 0.48. Their success can be understood as a result of conceptual simplicity and parametric parsimony, which obviously best fits the relatively simple classification task. It is found that, on summer days, CatRaRE convective atmospheres over Germany occur with a probability of about 0.5. This probability is projected to increase, regardless of method, both in ERA5-reanalyzed and CORDEX-simulated atmospheres: for the historical period we find a centennial increase of about 0.2 and for the future period one of slightly below 0.1.}, language = {en} } @article{HeistermannFranckeScheiffeleetal.2023, author = {Heistermann, Maik and Francke, Till and Scheiffele, Lena and Petrova, Katya Dimitrova and Budach, Christian and Schr{\"o}n, Martin and Trost, Benjamin and Rasche, Daniel and G{\"u}ntner, Andreas and Doepper, Veronika and F{\"o}rster, Michael and K{\"o}hli, Markus and Angermann, Lisa and Antonoglou, Nikolaos and Zude, Manuela and Oswald, Sascha}, title = {Three years of soil moisture observations by a dense cosmic-ray neutron sensing cluster at an agricultural research site in north-east Germany}, series = {Earth system science data : ESSD}, volume = {15}, journal = {Earth system science data : ESSD}, number = {7}, publisher = {Copernics Publications}, address = {Katlenburg-Lindau}, issn = {1866-3508}, doi = {10.5194/essd-15-3243-2023}, pages = {3243 -- 3262}, year = {2023}, abstract = {Cosmic-ray neutron sensing (CRNS) allows for the estimation of root-zone soil water content (SWC) at the scale of several hectares. In this paper, we present the data recorded by a dense CRNS network operated from 2019 to 2022 at an agricultural research site in Marquardt, Germany - the first multi-year CRNS cluster. Consisting, at its core, of eight permanently installed CRNS sensors, the cluster was supplemented by a wealth of complementary measurements: data from seven additional temporary CRNS sensors, partly co-located with the permanent ones; 27 SWC profiles (mostly permanent); two groundwater observation wells; meteorological records; and Global Navigation Satellite System reflectometry (GNSS-R). Complementary to these continuous measurements, numerous campaign-based activities provided data by mobile CRNS roving, hyperspectral im-agery via UASs, intensive manual sampling of soil properties (SWC, bulk density, organic matter, texture, soil hydraulic properties), and observations of biomass and snow (cover, depth, and density). The unique temporal coverage of 3 years entails a broad spectrum of hydro-meteorological conditions, including exceptional drought periods and extreme rainfall but also episodes of snow coverage, as well as a dedicated irrigation experiment. Apart from serving to advance CRNS-related retrieval methods, this data set is expected to be useful for vari-ous disciplines, for example, soil and groundwater hydrology, agriculture, or remote sensing. Hence, we show exemplary features of the data set in order to highlight the potential for such subsequent studies. The data are available at doi.org/10.23728/b2share.551095325d74431881185fba1eb09c95 (Heistermann et al., 2022b).}, language = {en} } @article{KuekenTrevesNikoloski2023, author = {K{\"u}ken, Anika and Treves, Haim and Nikoloski, Zoran}, title = {A simulation-free constrained regression approach for flux estimation in isotopically nonstationary metabolic flux analysis with applications in microalgae}, series = {Frontiers in plant science : FPLS}, volume = {14}, journal = {Frontiers in plant science : FPLS}, publisher = {Frontiers Media}, address = {Lausanne}, issn = {1664-462X}, doi = {10.3389/fpls.2023.1140829}, pages = {12}, year = {2023}, abstract = {Introduction Flux phenotypes from different organisms and growth conditions allow better understanding of differential metabolic networks functions. Fluxes of metabolic reactions represent the integrated outcome of transcription, translation, and post-translational modifications, and directly affect growth and fitness. However, fluxes of intracellular metabolic reactions cannot be directly measured, but are estimated via metabolic flux analysis (MFA) that integrates data on isotope labeling patterns of metabolites with metabolic models. While the application of metabolomics technologies in photosynthetic organisms have resulted in unprecedented data from 13CO2-labeling experiments, the bottleneck in flux estimation remains the application of isotopically nonstationary MFA (INST-MFA). INST-MFA entails fitting a (large) system of coupled ordinary differential equations, with metabolite pools and reaction fluxes as parameters. Here, we focus on the Calvin-Benson cycle (CBC) as a key pathway for carbon fixation in photosynthesizing organisms and ask if approaches other than classical INST-MFA can provide reliable estimation of fluxes for reactions comprising this pathway. Methods First, we show that flux estimation with the labeling patterns of all CBC intermediates can be formulated as a single constrained regression problem, avoiding the need for repeated simulation of time-resolved labeling patterns. Results We then compare the flux estimates of the simulation-free constrained regression approach with those obtained from the classical INST-MFA based on labeling patterns of metabolites from the microalgae Chlamydomonas reinhardtii, Chlorella sorokiniana and Chlorella ohadii under different growth conditions. Discussion Our findings indicate that, in data-rich scenarios, simulation-free regression-based approaches provide a suitable alternative for flux estimation from classical INST-MFA since we observe a high qualitative agreement (rs=0.89) to predictions obtained from INCA, a state-of-the-art tool for INST-MFA.}, language = {en} } @article{PuchkovMuellerLehmannetal.2023, author = {Puchkov, Dmytro and M{\"u}ller, Paul Markus and Lehmann, Martin and Matth{\"a}us, Claudia}, title = {Analyzing the cellular plasma membrane by fast and efficient correlative STED and platinum replica EM}, series = {Frontiers in cell and developmental biology}, volume = {11}, journal = {Frontiers in cell and developmental biology}, publisher = {Frontiers Media}, address = {Lausanne}, issn = {2296-634X}, doi = {10.3389/fcell.2023.1305680}, pages = {15}, year = {2023}, abstract = {The plasma membrane of mammalian cells links transmembrane receptors, various structural components, and membrane-binding proteins to subcellular processes, allowing inter- and intracellular communication. Therefore, membrane-binding proteins, together with structural components such as actin filaments, modulate the cell membrane in their flexibility, stiffness, and curvature. Investigating membrane components and curvature in cells remains challenging due to the diffraction limit in light microscopy. Preparation of 5-15-nm-thin plasma membrane sheets and subsequent inspection by metal replica transmission electron microscopy (TEM) reveal detailed information about the cellular membrane topology, including the structure and curvature. However, electron microscopy cannot identify proteins associated with specific plasma membrane domains. Here, we describe a novel adaptation of correlative super-resolution light microscopy and platinum replica TEM (CLEM-PREM), allowing the analysis of plasma membrane sheets with respect to their structural details, curvature, and associated protein composition. We suggest a number of shortcuts and troubleshooting solutions to contemporary PREM protocols. Thus, implementation of super-resolution stimulated emission depletion (STED) microscopy offers significant reduction in sample preparation time and reduced technical challenges for imaging and analysis. Additionally, highly technical challenges associated with replica preparation and transfer on a TEM grid can be overcome by scanning electron microscopy (SEM) imaging. The combination of STED microscopy and platinum replica SEM or TEM provides the highest spatial resolution of plasma membrane proteins and their underlying membrane and is, therefore, a suitable method to study cellular events like endocytosis, membrane trafficking, or membrane tension adaptations.}, language = {en} } @article{GutzeitTiberius2023, author = {Gutzeit, Lilly Joan and Tiberius, Victor}, title = {Business and management research on the motion picture industry}, series = {Journalism and media}, volume = {4}, journal = {Journalism and media}, number = {4}, publisher = {MDPI}, address = {Basel}, issn = {2673-5172}, doi = {10.3390/journalmedia4040076}, pages = {1198 -- 1210}, year = {2023}, abstract = {The motion picture industry is subject to extensive business and management research conducted on a wide range of topics. Due to high research productivity, it is challenging to keep track of the abundance of publications. Against this background, we employ a bibliographic coupling analysis to gain a comprehensive understanding of current research topics. The following themes were defined: Key factors for success, word of mouth and social media, organizational and pedagogical dimensions, advertising—product placement and online marketing, tourism, the influence of data, the influence of culture, revenue maximization and purchase decisions, and the perception and identification of audiences. Based on the cluster analysis, we suggest the following future research opportunities: Exploring technological innovations, especially the influence of social media and streaming platforms in the film industry; the in-depth analysis of the use of artificial intelligence in film production, both in terms of its creative potential and ethical and legal challenges; the exploration of the representation of wokeness and minorities in films and their cultural and economic significance; and, finally, a detailed examination of the long-term effects of the COVID-19 pandemic and other crises on the film industry, especially in terms of changed consumption habits and structural adjustments.}, language = {en} } @article{ZhouFischerBrahmsetal.2023, author = {Zhou, Lin and Fischer, Eric and Brahms, Clemens Markus and Granacher, Urs and Arnrich, Bert}, title = {DUO-GAIT}, series = {Scientific data}, volume = {10}, journal = {Scientific data}, number = {1}, publisher = {Nature Publ. Group}, address = {London}, issn = {2052-4463}, doi = {10.1038/s41597-023-02391-w}, pages = {10}, year = {2023}, abstract = {In recent years, there has been a growing interest in developing and evaluating gait analysis algorithms based on inertial measurement unit (IMU) data, which has important implications, including sports, assessment of diseases, and rehabilitation. Multi-tasking and physical fatigue are two relevant aspects of daily life gait monitoring, but there is a lack of publicly available datasets to support the development and testing of methods using a mobile IMU setup. We present a dataset consisting of 6-minute walks under single- (only walking) and dual-task (walking while performing a cognitive task) conditions in unfatigued and fatigued states from sixteen healthy adults. Especially, nine IMUs were placed on the head, chest, lower back, wrists, legs, and feet to record under each of the above-mentioned conditions. The dataset also includes a rich set of spatio-temporal gait parameters that capture the aspects of pace, symmetry, and variability, as well as additional study-related information to support further analysis. This dataset can serve as a foundation for future research on gait monitoring in free-living environments.}, language = {en} } @article{ZiubanovaLaurinavichyuteParshina2023, author = {Ziubanova, Anastasia A. and Laurinavichyute, Anna and Parshina, Olga}, title = {Does early exposure to spoken and sign language affect reading fluency in deaf and hard-of-hearing adult signers?}, series = {Frontiers in psychology}, volume = {14}, journal = {Frontiers in psychology}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1664-1078}, doi = {10.3389/fpsyg.2023.1145638}, pages = {9}, year = {2023}, abstract = {Introduction Early linguistic background, and in particular, access to language, lays the foundation of future reading skills in deaf and hard-of-hearing signers. The current study aims to estimate the impact of two factors - early access to sign and/or spoken language - on reading fluency in deaf and hard-of-hearing adult Russian Sign Language speakers. Methods In the eye-tracking experiment, 26 deaf and 14 hard-of-hearing native Russian Sign Language speakers read 144 sentences from the Russian Sentence Corpus. Analysis of global eye-movement trajectories (scanpaths) was used to identify clusters of typical reading trajectories. The role of early access to sign and spoken language as well as vocabulary size as predictors of the more fluent reading pattern was tested. Results Hard-of-hearing signers with early access to sign language read more fluently than those who were exposed to sign language later in life or deaf signers without access to speech sounds. No association between early access to spoken language and reading fluency was found. Discussion Our results suggest a unique advantage for the hard-of-hearing individuals from having early access to both sign and spoken language and support the existing claims that early exposure to sign language is beneficial not only for deaf but also for hard-of-hearing children.}, language = {en} } @article{CordobaTongBurgosetal.2023, author = {C{\´o}rdoba, Sandra Correa and Tong, Hao and Burgos, Asdrubal and Zhu, Feng and Alseekh, Saleh and Fernie, Alisdair and Nikoloski, Zoran}, title = {Identification of gene function based on models capturing natural variability of Arabidopsis thaliana lipid metabolism}, series = {Nature Communications}, volume = {14}, journal = {Nature Communications}, number = {1}, publisher = {Springer Nature}, address = {London}, issn = {2041-1723}, doi = {10.1038/s41467-023-40644-9}, pages = {12}, year = {2023}, abstract = {The use of automated tools to reconstruct lipid metabolic pathways is not warranted in plants. Here, the authors construct Plant Lipid Module for Arabidopsis rosette using constraint-based modeling, demonstrate its integration in other plant metabolic models, and use it to dissect the genetic architecture of lipid metabolism. Lipids play fundamental roles in regulating agronomically important traits. Advances in plant lipid metabolism have until recently largely been based on reductionist approaches, although modulation of its components can have system-wide effects. However, existing models of plant lipid metabolism provide lumped representations, hindering detailed study of component modulation. Here, we present the Plant Lipid Module (PLM) which provides a mechanistic description of lipid metabolism in the Arabidopsis thaliana rosette. We demonstrate that the PLM can be readily integrated in models of A. thaliana Col-0 metabolism, yielding accurate predictions (83\%) of single lethal knock-outs and 75\% concordance between measured transcript and predicted flux changes under extended darkness. Genome-wide associations with fluxes obtained by integrating the PLM in diel condition- and accession-specific models identify up to 65 candidate genes modulating A. thaliana lipid metabolism. Using mutant lines, we validate up to 40\% of the candidates, paving the way for identification of metabolic gene function based on models capturing natural variability in metabolism.}, language = {en} } @article{DettmannHuittinenNicolasetal.2023, author = {Dettmann, Sophie and Huittinen, Nina Maria and Nicolas, Jahn and Kretzschmar, Jerome and Kumke, Michael Uwe and Kutyma, Tamara and Lohmann, Janik and Reich, Tobias and Schmeide, Katja and Azzam, Salim Shams Aldin and Spittler, Leon and Stietz, Janina}, title = {Influence of gluconate on the retention of Eu(III), Am(III), Th(IV), Pu(IV), and U(VI) by C-S-H (C/S = 0.8)}, series = {Frontiers in Nuclear Engineering}, volume = {2}, journal = {Frontiers in Nuclear Engineering}, publisher = {Frontiers Media}, address = {Lausanne}, issn = {2813-3412}, doi = {10.3389/fnuen.2023.1124856}, pages = {15}, year = {2023}, abstract = {The retention of actinides in different oxidation states (An(X), X = III, IV, VI) by a calcium-silicate-hydrate (C-S-H) phase with a Ca/Si (C/S) ratio of 0.8 was investigated in the presence of gluconate (GLU). The actinides considered were Am(III), Th(IV), Pu(IV), and U(VI). Eu(III) was investigated as chemical analogue for Am(III) and Cm(III). In addition to the ternary systems An(X)/GLU/C-S-H, also binary systems An(X)/C-S-H, GLU/C-S-H, and An(X)/GLU were studied. Complementary analytical techniques were applied to address the different specific aspects of the binary and ternary systems. Time-resolved laser-induced luminescence spectroscopy (TRLFS) was applied in combination with parallel factor analysis (PARAFAC) to identify retained species and to monitor species-selective sorption kinetics. ¹³C and ²⁹Si magic-angle-spinning (MAS) nuclear magnetic resonance (NMR) spectroscopy and X-ray photoelectron spectroscopy (XPS) were applied to determine the bulk structure and the composition of the C-S-H surface, respectively, in the absence and presence of GLU. The interaction of Th(IV) with GLU in different electrolytes was studied by capillary electrophoresis-inductively coupled plasma mass spectrometry (CE-ICP-MS). The influence of GLU on An(X) retention was investigated for a large concentration range up to 10⁻² M. The results showed that GLU had little to no effect on the overall An(X) retention by C-S-H with C/S of 0.8, regardless of the oxidation state of the actinides. For Eu(III), the TRLFS investigations additionally implied the formation of a Eu(III)-bearing precipitate with dissolved constituents of the C-S-H phase, which becomes structurally altered by the presence of GLU. For U(VI) sorption on the C-S-H phase, only a small influence of GLU could be established in the luminescence spectroscopic investigations, and no precipitation of U(VI)-containing secondary phases could be identified.}, language = {en} } @article{ChemuraSchrumpfGuenteretal.2023, author = {Chemura, Sitshengisiwe and Schrumpf, Tim and G{\"u}nter, Christina and Kumke, Michael Uwe}, title = {Ceria nanomaterials containing ytterbium}, series = {RSC Advances : an international journal to further the chemical sciences}, volume = {13}, journal = {RSC Advances : an international journal to further the chemical sciences}, number = {50}, publisher = {RSC Publishing}, address = {London}, issn = {2046-2069}, doi = {10.1039/D3RA06868D}, pages = {35445 -- 35456}, year = {2023}, abstract = {Lanthanide based ceria nanomaterials are important practical materials due to the redox properties that are useful in the avenues pertaining to technology and life sciences. Sub 10 nm spherical and highly monodisperse Ce1-xYbxO2-y (0.04 ≤ x ≤ 0.22) nanoparticles were synthesized by thermal decomposition, annealed separately at 773 K and 1273 K for 2 hours and characterized. Elemental mapping for Yb3+ doped ceria nanoparticles shows homogeneous distribution of Yb3+ atoms in the ceria with low Yb3+ content annealed at 773 K and 1273 K for 2 hours. However, clusters are observed for 773 K annealed ceria samples with high concentration of Yb3+. These clusters are not detected in 1273 K annealed nanomaterials. Introducing small amounts of Yb3+ ions into the ceria lattice as spectroscopic probes can provide detailed information about the atomic structure and local environments allowing the monitoring of small structural changes, such as clustering. The emission spectra observed at room temperature and at 4 K have a manifold of bands that corresponds to the 2F5/2 → 2F7/2 transition of Yb3+ ions. Some small shifts are observed in the Stark splitting pattern depending on the sample and the annealing conditions. The deconvolution by PARAFAC analysis yielded luminescence decay kinetics as well as the associated luminescence spectra of three species for each of the low Yb3+ doped ceria samples annealed at 773 K and one species for the 1273 K annealed samples. However, the ceria samples with high concentration of Yb3+ annealed at the two temperatures showed only one species with lower decay times as compared to the low Yb3+ doped ceria samples.}, language = {en} } @article{RuszkiewiczEndigGueveretal.2023, author = {Ruszkiewicz, Joanna and Endig, Lisa and G{\"u}ver, Ebru and B{\"u}rkle, Alexander and Mangerich, Aswin}, title = {Life-cycle-dependent toxicities of mono- and bifunctional alkylating agents in the 3R-compliant model organism C. elegans}, series = {Cells : open access journal}, volume = {12}, journal = {Cells : open access journal}, number = {23}, publisher = {MDPI}, address = {Basel}, issn = {2073-4409}, doi = {10.3390/cells12232728}, pages = {16}, year = {2023}, abstract = {Caenorhabditis elegans (C. elegans) is gaining recognition and importance as an organismic model for toxicity testing in line with the 3Rs principle (replace, reduce, refine). In this study, we explored the use of C. elegans to examine the toxicities of alkylating sulphur mustard analogues, specifically the monofunctional agent 2-chloroethyl-ethyl sulphide (CEES) and the bifunctional, crosslinking agent mechlorethamine (HN2). We exposed wild-type worms at different life cycle stages (from larvae L1 to adulthood day 10) to CEES or HN2 and scored their viability 24 h later. The susceptibility of C. elegans to CEES and HN2 paralleled that of human cells, with HN2 exhibiting higher toxicity than CEES, reflected in LC50 values in the high µM to low mM range. Importantly, the effects were dependent on the worms' developmental stage as well as organismic age: the highest susceptibility was observed in L1, whereas the lowest was observed in L4 worms. In adult worms, susceptibility to alkylating agents increased with advanced age, especially to HN2. To examine reproductive effects, L4 worms were exposed to CEES and HN2, and both the offspring and the percentage of unhatched eggs were assessed. Moreover, germline apoptosis was assessed by using ced-1p::GFP (MD701) worms. In contrast to concentrations that elicited low toxicities to L4 worms, CEES and HN2 were highly toxic to germline cells, manifesting as increased germline apoptosis as well as reduced offspring number and percentage of eggs hatched. Again, HN2 exhibited stronger effects than CEES. Compound specificity was also evident in toxicities to dopaminergic neurons-HN2 exposure affected expression of dopamine transporter DAT-1 (strain BY200) at lower concentrations than CEES, suggesting a higher neurotoxic effect. Mechanistically, nicotinamide adenine dinucleotide (NAD+) has been linked to mustard agent toxicities. Therefore, the NAD+-dependent system was investigated in the response to CEES and HN2 treatment. Overall NAD+ levels in worm extracts were revealed to be largely resistant to mustard exposure except for high concentrations, which lowered the NAD+ levels in L4 worms 24 h post-treatment. Interestingly, however, mutant worms lacking components of NAD+-dependent pathways involved in genome maintenance, namely pme-2, parg-2, and sirt-2.1 showed a higher and compound-specific susceptibility, indicating an active role of NAD+ in genotoxic stress response. In conclusion, the present results demonstrate that C. elegans represents an attractive model to study the toxicology of alkylating agents, which supports its use in mechanistic as well as intervention studies with major strength in the possibility to analyze toxicities at different life cycle stages.}, language = {en} } @article{RuszkiewiczPapatheodorouJaecketal.2023, author = {Ruszkiewicz, Joanna and Papatheodorou, Ylea and J{\"a}ck, Nathalie and Melzig, Jasmin and Eble, Franziska and Pirker, Annika and Thomann, Marius and Haberer, Andreas and Rothmiller, Simone and B{\"u}rkle, Alexander and Mangerich, Aswin}, title = {NAD+ Acts as a protective factor in cellular stress response to DNA alkylating agents}, series = {Cells : open access journal}, volume = {12}, journal = {Cells : open access journal}, number = {19}, publisher = {MDPI}, address = {Basel}, issn = {2073-4409}, doi = {10.3390/cells12192396}, pages = {22}, year = {2023}, abstract = {Sulfur mustard (SM) and its derivatives are potent genotoxic agents, which have been shown to trigger the activation of poly (ADP-ribose) polymerases (PARPs) and the depletion of their substrate, nicotinamide adenine dinucleotide (NAD+). NAD+ is an essential molecule involved in numerous cellular pathways, including genome integrity and DNA repair, and thus, NAD+ supplementation might be beneficial for mitigating mustard-induced (geno)toxicity. In this study, the role of NAD+ depletion and elevation in the genotoxic stress response to SM derivatives, i.e., the monofunctional agent 2-chloroethyl-ethyl sulfide (CEES) and the crosslinking agent mechlorethamine (HN2), was investigated with the use of NAD+ booster nicotinamide riboside (NR) and NAD+ synthesis inhibitor FK866. The effects were analyzed in immortalized human keratinocytes (HaCaT) or monocyte-like cell line THP-1. In HaCaT cells, NR supplementation, increased NAD+ levels, and elevated PAR response, however, did not affect ATP levels or DNA damage repair, nor did it attenuate long- and short-term cytotoxicities. On the other hand, the depletion of cellular NAD+ via FK866 sensitized HaCaT cells to genotoxic stress, particularly CEES exposure, whereas NR supplementation, by increasing cellular NAD+ levels, rescued the sensitizing FK866 effect. Intriguingly, in THP-1 cells, the NR-induced elevation of cellular NAD+ levels did attenuate toxicity of the mustard compounds, especially upon CEES exposure. Together, our results reveal that NAD+ is an important molecule in the pathomechanism of SM derivatives, exhibiting compound-specificity. Moreover, the cell line-dependent protective effects of NR are indicative of system-specificity of the application of this NAD+ booster.}, language = {en} } @article{UthBlestelSanchezMoreano2024, author = {Uth, Melanie and Blestel, {\´E}lodie and S{\´a}nchez Moreano, Santiago}, title = {Labialization of final nasals}, series = {Forma y funci{\´o}n}, volume = {37}, journal = {Forma y funci{\´o}n}, number = {1}, publisher = {Universidad Nacional de Colombia, Facultad de Ciencias Humanas}, address = {Bogot{\´a}}, issn = {2256-5469}, doi = {10.15446/fyf.v37n1.104644}, pages = {1 -- 25}, year = {2024}, abstract = {Comparamos la labializaci{\´o}n no asimiladora de nasales finales en espa{\~n}ol en tres corpus de espa{\~n}ol americano (mexicano, colombiano y paraguayo). Si bien es conocida la labializaci{\´o}n no asimiladora en espa{\~n}ol yucateco, es en gran parte desconocida en otras regiones de habla hispana, por lo que a menudo se atribuye a la influencia maya. Ahora bien, se han se{\~n}alado casualmente h{\´a}bitos de pronunciaci{\´o}n similares tanto en Paraguay como en Colombia. Comparando emp{\´i}ricamente la labializaci{\´o}n en tres corpus constituidos sobre la misma base metodol{\´o}gica, concluimos que la evidencia a favor del contacto ling{\"u}{\´i}stico es como mucho sumamente indirecta. Independientemente de esto, encontramos que la diferencia m{\´a}s marcada es que la tasa de labializaci{\´o}n parece ser determinada por la duraci{\´o}n de la pausa subsiguiente en los datos de la pen{\´i}nsula yucateca, mas no en aquellos de Colombia y Paraguay. Argumentamos que es cierto que el contacto puede eventualmente haber desencadenado el desarrollo de este rasgo en el espa{\~n}ol yucateco, puesto que el espa{\~n}ol actual casi no conoce nasales labiales finales, pero el maya s{\´i}. Sin embargo, el perfil ling{\"u}{\´i}stico (hablantes monoling{\"u}es vs. biling{\"u}es) no tiene ning{\´u}n efecto en nuestros datos yucatecos y paraguayos, y en el total de nuestros datos tampoco encontramos evidencia en favor de la hip{\´o}tesis que el contacto ling{\"u}{\´i}stico hubiera jugado un rol (importante) en el desarrollo de las labiales nasales en las tres variedades.}, language = {es} } @article{CarlaUhinkGarciaMorcillo2024, author = {Carl{\`a}-Uhink, Filippo and Garc{\´i}a Morcillo, Marta}, title = {Problemas y desaf{\´i}os de la investigaci{\´o}n hist{\´o}rica sobre la corrupci{\´o}n}, series = {Eunom{\´i}a : Revista en Cultura de la Legalidad}, volume = {26}, journal = {Eunom{\´i}a : Revista en Cultura de la Legalidad}, publisher = {Madrid}, address = {Universidad Carlos III de Madrid}, issn = {2253-6655}, doi = {https://doi.org/10.20318/eunomia.2024.8506}, pages = {146 -- 164}, year = {2024}, abstract = {El art{\´i}culo analiza la corrupci{\´o}n como un fen{\´o}meno complejo y con frecuencia ambiguo, relacionado con comportamientos y mentalidades individuales y colectivas, que son percibidos como ileg{\´i}timos o inmorales y, por lo tanto, desviados de normas establecidas. M{\´a}s all{\´a} de un acercamiento reduccionista u objetivista a lugares comunes de la corrupci{\´o}n pol{\´i}tica, o a delitos tipificados por la ley, esta contribuci{\´o}n pretende destacar la relevancia del an{\´a}lisis hist{\´o}rico del discurso en el estudio del tema. Este enfoque nos permite reconstruir contextos en los que se identifica la corrupci{\´o}n, as{\´i} como analizar relatos, no siempre un{\´a}nimes, sobre estas pr{\´a}cticas. El trabajo se adentra en una {\´e}poca lejana, pero a la vez cercana a nuestro tiempo, el {\´u}ltimo siglo la Rep{\´u}blica romana. La evidencia nos permite evaluar cr{\´i}ticamente aspectos fundamentales de la construcci{\´o}n ret{\´o}rica de la corrupci{\´o}n y de sus zonas grises, como la distinci{\´o}n, a menudo borrosa, entre regalo y soborno.}, language = {es} } @article{HomolkaPryba2024, author = {Homolka, Walter and Pryba, Andrzej}, title = {Preparations for Marriage in the Jewish and Catholic Traditions}, series = {Religions}, volume = {15}, journal = {Religions}, number = {62}, publisher = {MDPI}, address = {Basel}, issn = {2077-1444}, doi = {https://doi.org/10.3390/rel15010062}, pages = {1 -- 14}, year = {2024}, abstract = {In many churches nowadays, there has been a standardized approach to premarital counseling for couples involving social, pastoral, and psychological perspectives. In contrast, many rabbis and other Jewish officials still concentrate on legal aspects alone. The need for resolving important issues on the verge of wedlock is too often left to secular experts in law, psychology, or counseling. However, in recent years, this lack of formal training for marriage preparation has also been acknowledged by the Jewish clergy in order to incorporate it in the preparatory period before the bond is tied. This case study focuses on Jewish and Roman Catholic conceptions of marriage, past and present. We intend to do a comparative analysis of the prerequisites of religious marriage based on the assumption that both Judaism and the Roman Catholic Church have a distinct legal framework to assess marriage preparation.}, language = {en} } @article{LimSamperMejia2024, author = {Lim, Misun and Samper Mejia, Cristina}, title = {Race and cohort differences in family status in the United States}, series = {Socius : sociological research for a dynamic world}, volume = {10}, journal = {Socius : sociological research for a dynamic world}, publisher = {Sage Publications}, address = {London}, issn = {2378-0231}, doi = {10.1177/23780231241241041}, pages = {1 -- 4}, year = {2024}, abstract = {In this visualization, the authors show changes in family patterns by different race groups across two cohorts. Using data from the National Longitudinal Survey of Youth 1979 (born from 1957 to 1965) and 1997 (born from 1980 to 1984), the authors visualize the relationship-parenthood state distributions at each age between 15 and 35 years by race and cohort. The results suggest the rise of cohabiting mothers and the decline of married and divorced mothers among women born from 1980 to 1984. Black women born from 1980 to 1984 were more likely to experience single/childless and single/parent status compared with Black women born from 1957 to 1965. Although with some visible postponement in the recent cohort, white women in both cohorts were more likely to experience married/parent status than other race groups. The decline in married/parent status across the two generations was sharpest among Hispanic women. These descriptive findings highlight the importance of identifying race when discussing changes in family formation and dissolution trends across generations.}, language = {en} } @article{SancıKardas2024, author = {Sanc{\i}, Kadir and Kardas, Arhan}, title = {Die islamische Speiseordnung}, series = {Du sollst nicht essen: Warum Menschen auf Nahrung verzichten - interdisziplin{\"a}re Zug{\"a}nge}, journal = {Du sollst nicht essen: Warum Menschen auf Nahrung verzichten - interdisziplin{\"a}re Zug{\"a}nge}, editor = {Kollodzeiski, Ulrike and Hafner, Johann Evangelist}, publisher = {Ergon Verlag}, address = {Baden-Baden}, isbn = {978-3-98740-007-0}, doi = {10.5771/9783987400087}, pages = {105 -- 124}, year = {2024}, language = {de} } @article{Schweigert2024, author = {Schweigert, Florian J.}, title = {H{\"a}sslich aber gut}, series = {Du sollst nicht essen: Warum Menschen auf Nahrung verzichten - interdisziplin{\"a}re Zug{\"a}nge}, journal = {Du sollst nicht essen: Warum Menschen auf Nahrung verzichten - interdisziplin{\"a}re Zug{\"a}nge}, editor = {Kollodzeiski, Ulrike and Hafner, Johann Evangelist}, publisher = {Ergon Verlag}, address = {Baden-Baden}, isbn = {978-3-98740-007-0}, doi = {10.5771/9783987400087}, pages = {47 -- 59}, year = {2024}, language = {de} } @article{SchmidtWellenburg2024, author = {Schmidt-Wellenburg, Christian}, title = {French economists and the symbolic power of (post-)national scopes of capital}, series = {Serendipities : journal for the sociology and history of the social sciences}, volume = {8}, journal = {Serendipities : journal for the sociology and history of the social sciences}, number = {1-2}, publisher = {Karl-Franzens-Universit{\"a}t Graz}, address = {Graz}, issn = {2521-0947}, doi = {10.7146/serendipities.v8i1-2.133990}, pages = {77 -- 108}, year = {2024}, abstract = {The paper argues that economists' position-taking in discourses of crises should be understood in the light of economists' positions in the academic field of economics. This hypothesis is investigated by performing a multiple correspondence analysis (MCA) on a prosopographical data set of 144 French economists who positioned themselves between 2008 and 2021 in controversies over the euro crisis, the French political economic model, and French economics. In these disciplinary controversies, different forms of (post-)national academic capital are used by economists to either initiate change or defend the status quo. These strategies are then interpreted as part of more general power struggles over the basic national or post-national constitution and legitimate governance of economy and society.}, language = {en} } @article{Krochmalnik2024, author = {Krochmalnik, Daniel}, title = {Kaschrut}, series = {Du sollst nicht essen: Warum Menschen auf Nahrung verzichten - interdisziplin{\"a}re Zug{\"a}nge}, journal = {Du sollst nicht essen: Warum Menschen auf Nahrung verzichten - interdisziplin{\"a}re Zug{\"a}nge}, editor = {Kollodzeiski, Ulrike and Hafner, Johann Evangelist}, isbn = {978-3-98740-007-0}, doi = {10.5771/9783987400087}, pages = {91 -- 104}, year = {2024}, language = {de} } @article{Kollodzeiski2024, author = {Kollodzeiski, Ulrike}, title = {„Keine Seele von euch soll Blut essen!" (Lev 17,12)}, series = {Du sollst nicht essen: Warum Menschen auf Nahrung verzichten - interdisziplin{\"a}re Zug{\"a}nge}, journal = {Du sollst nicht essen: Warum Menschen auf Nahrung verzichten - interdisziplin{\"a}re Zug{\"a}nge}, editor = {Kollodzeiski, Ulrike and Hafner, Johann Evangelist}, publisher = {Ergon Verlag}, address = {Baden-Baden}, isbn = {978-3-98740-007-0}, doi = {10.5771/9783987400087}, pages = {77 -- 89}, year = {2024}, language = {de} } @article{Olhoeft2024, author = {Olhoeft, Netanel}, title = {„Und Nahrung labt das Herz der Menschen" (Ps 104,15)}, series = {Du sollst nicht essen: Warum Menschen auf Nahrung verzichten - interdisziplin{\"a}re Zug{\"a}nge}, journal = {Du sollst nicht essen: Warum Menschen auf Nahrung verzichten - interdisziplin{\"a}re Zug{\"a}nge}, editor = {Kollodzeiski, Ulrike and Hafner, Johann Evangelist}, publisher = {Ergon Verlag}, address = {Baden-Baden}, isbn = {978-3-98740-007-0}, doi = {10.5771/9783987400087}, pages = {153 -- 156}, year = {2024}, language = {de} } @article{Dietzel2024, author = {Dietzel, Irene}, title = {Fastenzeit und Kulinarik in der Orthodoxie}, series = {Du sollst nicht essen: Warum Menschen auf Nahrung verzichten - interdisziplin{\"a}re Zug{\"a}nge}, journal = {Du sollst nicht essen: Warum Menschen auf Nahrung verzichten - interdisziplin{\"a}re Zug{\"a}nge}, editor = {Kollodzeiski, Ulrike and Hafner, Johann Evangelist}, publisher = {Ergon Verlag}, address = {Baden-Baden}, isbn = {978-3-98740-007-0}, doi = {10.5771/9783987400087}, pages = {149 -- 150}, year = {2024}, language = {de} } @article{TjadenSeutheWeinert2024, author = {Tjaden, Jasper and Seuthe, Miriam and Weinert, Sebastian}, title = {Recruiting refugees to reduce labour shortages in health care professions}, series = {Human resources for health}, volume = {22}, journal = {Human resources for health}, publisher = {Biomed Central}, address = {London}, issn = {1478-4491}, doi = {10.1186/s12960-024-00933-w}, pages = {1 -- 9}, year = {2024}, abstract = {Background Many high-income countries are grappling with severe labour shortages in the healthcare sector. Refugees and recent migrants present a potential pool for staff recruitment due to their higher unemployment rates, younger age, and lower average educational attainment compared to the host society's labour force. Despite this, refugees and recent migrants, often possessing limited language skills in the destination country, are frequently excluded from traditional recruitment campaigns conducted solely in the host country's language. Even those with intermediate language skills may feel excluded, as destination-country language advertisements are perceived as targeting only native speakers. This study experimentally assesses the effectiveness of a recruitment campaign for nursing positions in a German care facility, specifically targeting Arabic and Ukrainian speakers through Facebook advertisements. Methods We employ an experimental design (AB test) approximating a randomized controlled trial, utilizing Facebook as the delivery platform. We compare job advertisements for nursing positions in the native languages of Arabic and Ukrainian speakers (treatment) with the same advertisements displayed in German (control) for the same target group in the context of a real recruitment campaign for nursing jobs in Berlin, Germany. Our evaluation includes comparing link click rates, visits to the recruitment website, initiated applications, and completed applications, along with the unit cost of these indicators. We assess statistical significance in group differences using the Chi-squared test. Results We find that recruitment efforts in the origin language were 5.6 times (Arabic speakers) and 1.9 times (Ukrainian speakers) more effective in initiating nursing job applications compared to the standard model of German-only advertisements among recent migrants and refugees. Overall, targeting refugees and recent migrants was 2.4 (Ukrainians) and 10.8 (Arabic) times cheaper than targeting the reference group of German speakers indicating higher interest among these groups. Conclusions The results underscore the substantial benefits for employers in utilizing targeted recruitment via social media aimed at foreign-language communities within the country. This strategy, which is low-cost and low effort compared to recruiting abroad or investing in digitalization, has the potential for broad applicability in numerous high-income countries with sizable migrant communities. Increased employment rates among underemployed refugee and migrant communities, in turn, contribute to reducing poverty, social exclusion, public expenditure, and foster greater acceptance of newcomers within the receiving society.}, language = {en} } @article{Kraft2024, author = {Kraft, Tobias}, title = {Neue Quellen zu Humboldts Kuba-Forschung. Das „Digitale Dossier" des Proyecto Humboldt Digital (2019-2023)}, series = {HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies}, volume = {XXV}, journal = {HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies}, number = {48}, editor = {Ette, Ottmar and Knobloch, Eberhard}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {2568-3543}, doi = {10.18443/373}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-646592}, pages = {25 -- 64}, year = {2024}, abstract = {Die deutsch-kubanische Forschungs- und Digitalisierungsinitiative „Proyecto Humboldt Digital" (ProHD) hat w{\"a}hrend ihrer Projektlaufzeit (2019-2023) wichtige Quellen zum Thema „Humboldt und Kuba" erstmals digital erschlossen. Als Kooperation zwischen der Berlin-Brandenburgischen Akademie der Wissenschaften und der Oficina del Historiador de la Ciudad de La Habana hat ProHD damit wichtige Akzente f{\"u}r die Archivdigitalisierung, die digitale Editionsphilologie und die digitale Wissenschaftskommunikation in Kuba gesetzt. Das Korpus der erschlossenen Best{\"a}nde wird hier in f{\"u}nf Schlaglichtern vorgestellt: 1) Quellen zur Humboldt'schen Forschungsreise, 2) Juan Luis de la Cuesta, 3) Materialien zu Kuba aus dem Humboldt-Nachlass, 4) Zensur und Beschlagnahme des Essai politique sur l'{\^i}le de Cuba, 5) Francisco de Arango y Parre{\~n}o.}, language = {de} } @article{Gao2024, author = {Gao, Hong}, title = {Nachgedanken zur {\"U}bersetzung des ersten Bandes von Humboldts „Kosmos"}, series = {HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies}, volume = {XXV}, journal = {HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies}, number = {48}, editor = {Ette, Ottmar and Knobloch, Eberhard}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {2568-3543}, doi = {10.18443/371}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-646569}, pages = {17 -- 24}, year = {2024}, abstract = {La traduction en langue chinoise du premier volume du monumental ouvrage scientifique d'Alexander von Humboldt, intitul{\´e} «Cosmos», a vu le jour en 2023 sous l՚{\´e}gide de la prestigieuse maison d՚{\´e}dition de l՚Universit{\´e} de P{\´e}kin. Dans sa postface {\´e}clair{\´e}e, la traductrice {\´e}m{\´e}rite, Gao Hong, {\´e}claire la lanterne des lecteurs chinois sur la fresque cosmique esquiss{\´e}e par Humboldt, r{\´e}v{\´e}lant ainsi les intrications entre les ph{\´e}nom{\`e}nes naturels et leur pertinence {\`a} l՚{\´e}chelle de l'univers tout entier. Gao Hong narre son propre p{\´e}riple aux c{\^o}t{\´e}s de Humboldt, tout en distillant ses r{\´e}flexions personnelles sur cette fresque cosmique. «Cosmos» d՚Humboldt, œuvre scientifique par excellence, transcende {\´e}galement les sph{\`e}res esth{\´e}tiques et artistiques, exprimant invariablement une profonde v{\´e}n{\´e}ration pour l՚univers. Restituer en chinois la «beaut{\´e} g{\´e}om{\´e}trique» de la langue allemande, empreinte d՚une rigueur structurelle, constitue un d{\´e}fi singulier, le chinois se caract{\´e}risant par sa fluidit{\´e}, sa souplesse et sa po{\´e}sie imag{\´e}e, en totale antith{\`e}se avec l՚allemand. En qualit{\´e} de traducteur, il importe de naviguer librement entre ces deux mondes linguistiques distincts.}, language = {de} } @article{EtteSchwarz2024, author = {Ette, Ottmar and Schwarz, Ingo}, title = {„Ein junges, neues Geschlecht wird besseres liefern als das alte". Ein Empfehlungsbrief Alexander von Humboldts f{\"u}r Carl Ludwig}, series = {HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies}, volume = {XXV}, journal = {HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies}, number = {48}, editor = {Ette, Ottmar and Knobloch, Eberhard}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {2568-3543}, doi = {10.18443/370}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-646552}, pages = {5 -- 15}, year = {2024}, abstract = {In dem Aufsatz wird ein Brief erstmalig ver{\"o}ffentlicht, in dem Alexander von Humboldt im Jahr 1849 bei einem Minister der liberalen Regierung von Kurhessen die Verdienste eines an der Universit{\"a}t in Marburg lehrenden jungen Professors hervorhob. Die Rede ist hier von dem sp{\"a}ter durch bahnbrechende Entdeckungen ber{\"u}hmten Physiologen Carl Ludwig. Vermittelt wurde das Schreiben durch den Humboldt nahestehenden Mediziner und Physiologen Emil du Bois-Reymond. Der Empfehlungsbrief, mit dem Humboldt versuchte, Ludwigs finanzielle Situation zu verbessern, ist ein Beispiel f{\"u}r die F{\"o}rderung junger Forscher wie auch freier wissenschaftlicher Institutionen durch Humboldt.}, language = {de} } @article{Kutzinski2024, author = {Kutzinski, Vera M.}, title = {Off-road adventures}, series = {HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies}, volume = {XXV}, journal = {HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies}, number = {48}, editor = {Ette, Ottmar and Knobloch, Eberhard}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {2568-3543}, doi = {10.18443/367}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-646601}, pages = {65 -- 86}, year = {2024}, abstract = {This article focuses on the visual qualities of Alexander von Humboldt's statistical tables in his Political Essay on the Kingdom of New Spain (1808-1811, 2nd ed. 1825-1827) with special attention to how such composites of numbers, alphabetical script, and semiotic elements relate to narrative writing. I argue that Humboldt's tables/tableaus open up spaces inside his narrative that fragment the reading process, inviting new conversations, connections, and ideas.}, language = {en} }