@article{BroennekeMuellerMouratisetal.2021,
  author    = {Br{\"o}nneke, Jan Benedikt and M{\"u}ller, Jennifer and Mouratis, Konstantinos and Hagen, Julia and Stern, Ariel Dora},
  title     = {Regulatory, legal, and market aspects of smart wearables for cardiac monitoring},
  series = {Sensors},
  volume    = {21},
  journal   = {Sensors},
  number    = {14},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {1424-8220},
  doi       = {10.3390/s21144937},
  pages     = {19},
  year      = {2021},
  abstract  = {In the area of cardiac monitoring, the use of digitally driven technologies is on the rise. While the development of medical products is advancing rapidly, allowing for new use-cases in cardiac monitoring and other areas, regulatory and legal requirements that govern market access are often evolving slowly, sometimes creating market barriers. This article gives a brief overview of the existing clinical studies regarding the use of smart wearables in cardiac monitoring and provides insight into the main regulatory and legal aspects that need to be considered when such products are intended to be used in a health care setting. Based on this brief overview, the article elaborates on the specific requirements in the main areas of authorization/certification and reimbursement/compensation, as well as data protection and data security. Three case studies are presented as examples of specific market access procedures: the USA, Germany, and Belgium. This article concludes that, despite the differences in specific requirements, market access pathways in most countries are characterized by a number of similarities, which should be considered early on in product development. The article also elaborates on how regulatory and legal requirements are currently being adapted for digitally driven wearables and proposes an ongoing evolution of these requirements to facilitate market access for beneficial medical technology in the future.},
  language  = {en}
}
@article{EgliMehrabiSeppelt2021,
  author    = {Egli, Lukas and Mehrabi, Zia and Seppelt, Ralf},
  title     = {More farms, less specialized landscapes, and higher crop diversity stabilize food supplies},
  series = {Environmental research letters},
  volume    = {16},
  journal   = {Environmental research letters},
  number    = {5},
  publisher = {IOP Publ. Ltd.},
  address   = {Bristol},
  issn      = {1748-9326},
  doi       = {10.1088/1748-9326/abf529},
  pages     = {10},
  year      = {2021},
  abstract  = {Theoretical and empirical studies show increased diversity in crops, supply chains, and markets helps stabilize food systems. At the same time global commodity markets and industrial agriculture have driven homogenization of local and regional production systems, and consolidated power in fewer larger specialized farms and distributers. This is a global challenge, with no obvious global solutions. An important question therefore, is how individual countries can build their own resilience through maintaining or increasing diversity within their borders. Here we show, using farm level data from Germany, that spreading production risk by growing the same crops across different farms carries stabilizing benefits by allowing for increased spatiotemporal asynchrony within crops. We also find that increasing asynchrony between the year-to-year production of different crops has stabilizing effects on food supply. Importantly, the benefits of increasing crop diversity are lower in specialized landscapes growing the same crop on large patches. Our results illustrate clear benefits of diversified crops, producers, and agricultural landscapes to buffer supply side shocks, and for incorporation in subsidies and other regulatory measures aimed at stabilizing food systems.},
  language  = {en}
}
@incollection{WolfFinzel2021,
  author    = {Wolf, Hans-Georg and Finzel, Anna},
  title     = {Colonial cultural conceptualizations and world Englishes},
  series = {Research developments in world englishes},
  booktitle = {Research developments in world englishes},
  publisher = {Bloomsbury Academic},
  address   = {London},
  isbn      = {978-1-3501-6708-7},
  doi       = {10.5040/9781350167087.ch-010},
  pages     = {199 -- 230},
  year      = {2021},
  abstract  = {In this paper, we take a cognitive-sociolinguistic perspective on texts from the colonial period. The texts stem from various agents in the colonial enterprise and include documents from missionaries, administrators and politicians, as well as legal and scientific texts. What we find and trace in these texts is a recurrent set of dominant systems of conceptualizations that are characteristic of the colonial mindset and the corresponding discourse at large. However, these conceptualizations were spelled out in quite different ways in discourse, depending on the ideological background and objectives of the authors and on the specific colonial setting they deal with. We will focus on two contexts, India and sub-Saharan Africa, and we will highlight conceptualizations related to the framing of the constellation between colonizers and colonial subjects in terms of, inter alia, a parent-child, an adult-child and a teacher-pupil relationship. We will then look into some examples of cultural practices among the colonized that were "disturbing" to the colonizers. The fact that they were betrays value systems as well as preoccupations and fears on the side of the colonizers. These practices triggered efforts at cultural engineering in the colonies which had lasting effects on the local culture in these settings. However, this impact was far from being one-directional. The experience with the "otherness" of the colonial subjects fueled debates on latent societal issues in the culture of the colonizers. We will consider this impact for the case of the discourse on homosexuality. The empire stroke back also in linguistic terms, most notably by a host of loan words that entered the lexicon of English. The way these loan words were "integrated" into the English language provides ample evidence of a cultural appropriation also in this direction, i.e., the process known as "contextualization" in traditional Kachruvian sociolinguistics is bi-directional as well.},
  language  = {en}
}
@article{ChromikKlopfensteinPfitzneretal.2022,
  author    = {Chromik, Jonas and Klopfenstein, Sophie Anne Ines and Pfitzner, Bjarne and Sinno, Zeena-Carola and Arnrich, Bert and Balzer, Felix and Poncette, Akira-Sebastian},
  title     = {Computational approaches to alleviate alarm fatigue in intensive care medicine: a systematic literature review},
  series = {Frontiers in digital health},
  volume    = {4},
  journal   = {Frontiers in digital health},
  publisher = {Frontiers Media},
  address   = {Lausanne},
  issn      = {2673-253X},
  doi       = {10.3389/fdgth.2022.843747},
  pages     = {15},
  year      = {2022},
  abstract  = {Patient monitoring technology has been used to guide therapy and alert staff when a vital sign leaves a predefined range in the intensive care unit (ICU) for decades. However, large amounts of technically false or clinically irrelevant alarms provoke alarm fatigue in staff leading to desensitisation towards critical alarms. With this systematic review, we are following the Preferred Reporting Items for Systematic Reviews (PRISMA) checklist in order to summarise scientific efforts that aimed to develop IT systems to reduce alarm fatigue in ICUs. 69 peer-reviewed publications were included. The majority of publications targeted the avoidance of technically false alarms, while the remainder focused on prediction of patient deterioration or alarm presentation. The investigated alarm types were mostly associated with heart rate or arrhythmia, followed by arterial blood pressure, oxygen saturation, and respiratory rate. Most publications focused on the development of software solutions, some on wearables, smartphones, or headmounted displays for delivering alarms to staff. The most commonly used statistical models were tree-based. In conclusion, we found strong evidence that alarm fatigue can be alleviated by IT-based solutions. However, future efforts should focus more on the avoidance of clinically non-actionable alarms which could be accelerated by improving the data availability.},
  language  = {en}
}
@article{JonesWiesner2022,
  author    = {Jones, Chris and Wiesner, Karoline},
  title     = {Clarifying how degree entropies and degree-degree correlations relate to network robustness},
  series = {Entropy : an international and interdisciplinary journal of entropy and information studies},
  volume    = {24},
  journal   = {Entropy : an international and interdisciplinary journal of entropy and information studies},
  number    = {9},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {1099-4300},
  doi       = {10.3390/e24091182},
  pages     = {13},
  year      = {2022},
  abstract  = {It is often claimed that the entropy of a network's degree distribution is a proxy for its robustness. Here, we clarify the link between degree distribution entropy and giant component robustness to node removal by showing that the former merely sets a lower bound to the latter for randomly configured networks when no other network characteristics are specified. Furthermore, we show that, for networks of fixed expected degree that follow degree distributions of the same form, the degree distribution entropy is not indicative of robustness. By contrast, we show that the remaining degree entropy and robustness have a positive monotonic relationship and give an analytic expression for the remaining degree entropy of the log-normal distribution. We also show that degree-degree correlations are not by themselves indicative of a network's robustness for real networks. We propose an adjustment to how mutual information is measured which better encapsulates structural properties related to robustness.},
  language  = {en}
}
@article{KindermannDoblerNiedeggenetal.2021,
  author    = {Kindermann, Liana and Dobler, Magnus and Niedeggen, Daniela and Linst{\"a}dter, Anja},
  title     = {A new protocol for estimation of woody aboveground biomass in disturbance-prone ecosystems},
  series = {Ecological indicators : integrating monitoring, assessment and management},
  volume    = {135},
  journal   = {Ecological indicators : integrating monitoring, assessment and management},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1470-160X},
  doi       = {10.1016/j.ecolind.2021.108466},
  pages     = {16},
  year      = {2021},
  abstract  = {Almost one third of global drylands are open forests and savannas, which are typically shaped by frequent natural disturbances such as wildfire and herbivory. Studies on ecosystem functions and services of woody vegetation require robust estimates of aboveground biomass (AGB). However, most methods have been developed for comparatively undisturbed forest ecosystems. As they are not tailored to accurately quantify AGB of small and irregular growth forms, their application on these growth forms may lead to unreliable or even biased AGB estimates in disturbance-prone dryland ecosystems. Moreover, these methods cannot quantify AGB losses caused by disturbance agents. Here we propose a methodology to estimate individual-and stand-level woody AGB in disturbance-prone ecosystems. It consists of flexible field sampling routines and estimation workflows for six growth classes, delineated by size and damage criteria. It also comprises a detailed damage assessment, harnessing the ecological archive of woody growth for past disturbances. Based on large inventories collected along steep gradients of elephant disturbances in African dryland ecosystems, we compared the AGB estimates generated with our proposed method against estimates from a less adapted forest inventory method. We evaluated the necessary stepwise procedures of method adaptation and analyzed each step's effect on stand-level AGB estimation. We further explored additional advantages of our proposed method with regard to disturbance impact quantification. Results indicate that a majority of growth forms and individuals in savanna vegetation could only be assessed if methods of AGB estimation were adapted to the conditions of a disturbance-prone ecosystem. Furthermore, our damage assessment demonstrated that one third to half of all woody AGB was lost to disturbances. Consequently, less adapted methods may be insufficient and are likely to render inaccurate AGB estimations. Our proposed method has the potential to accurately quantify woody AGB in disturbance-prone ecosystems, as well as AGB losses. Our method is more time consuming than conventional allometric approaches, yet it can cover sufficient areas within reasonable timespans, and can also be easily adapted to alternative sampling schemes.},
  language  = {en}
}
@article{KoertingKoellnerKurasetal.2021,
  author    = {K{\"o}rting, Friederike Magdalena and K{\"o}llner, Nicole and Kuras, Agnieszka and B{\"o}sche, Nina Kristin and Rogass, Christian and Mielke, Christian and Elger, Kirsten and Altenberger, Uwe},
  title     = {A solar optical hyperspectral library of rare-earth-bearing minerals, rare-earth oxide powders, copper-bearing minerals and Apliki mine surface samples},
  series = {Earth system science data : ESSD},
  volume    = {13},
  journal   = {Earth system science data : ESSD},
  publisher = {Copernics Publications},
  address   = {Katlenburg-Lindau},
  issn      = {1866-3508},
  doi       = {10.5194/essd-13-923-2021},
  pages     = {923 -- 942},
  year      = {2021},
  abstract  = {Mineral resource exploration and mining is an essential part of today's high-tech industry. Elements such as rare-earth elements (REEs) and copper are, therefore, in high demand. Modern exploration techniques from multiple platforms (e.g., spaceborne and airborne), to detect and map the spectral characteristics of the materials of interest, require spectral libraries as an essential reference. They include field and laboratory spectral information in combination with geochemical analyses for validation. Here, we present a collection of REE- and copper-related hyperspectral spectra with associated geochemical information. The libraries contain reflectance spectra from rare-earth element oxides, REE-bearing minerals, copper-bearing minerals and mine surface samples from the Apliki copper-gold-pyrite mine in the Republic of Cyprus. The samples were measured with the HySpex imaging spectrometers in the visible and near infrared (VNIR) and shortwave infrared (SWIR) range (400-2500 nm). The geochemical validation of each sample is provided with the reflectance spectra. The spectral libraries are openly available to assist future mineral mapping campaigns and laboratory spectroscopic analyses. The spectral libraries and corresponding geochemistry are published via GFZ Data Services with the following DOIs: https://doi.org/10.5880/GFZ.1.4.2019.004 (13 REE-bearing minerals and 16 oxide powders, Koerting et al., 2019a), https://doi.org/10.5880/GFZ.1.4.2019.003 (20 copper-bearing minerals, Koellner et al., 2019), and https://doi.org/10.5880/GFZ.1.4.2019.005 (37 copper-bearing surface material samples from the Apliki coppergold-pyrite mine in Cyprus, Koerting et al., 2019b). All spectral libraries are united and comparable by the internally consistent method of hyperspectral data acquisition in the laboratory.},
  language  = {en}
}
@article{KindermannDoblerNiedeggenetal.2022,
  author    = {Kindermann, Liana and Dobler, Magnus and Niedeggen, Daniela and Chimbioputo Fabiano, Ezequiel and Linst{\"a}dter, Anja},
  title     = {Dataset on woody aboveground biomass, disturbance losses, and wood density from an African savanna ecosystem},
  series = {Data in Brief},
  volume    = {42},
  journal   = {Data in Brief},
  publisher = {Elsevier},
  address   = {Amsterdam, Niederlande},
  issn      = {2352-3409},
  doi       = {10.1016/j.dib.2022.108155},
  pages     = {1 -- 16},
  year      = {2022},
  abstract  = {This dataset comprises tree inventories and damage assessments performed in Namibia's semi-arid Zambezi Region. Data were sampled in savannas and savanna woodlands along steep gradients of elephant population densities to capture the effects of those (and other) disturbances on individual-level and stand-level aboveground woody biomass (AGB). The dataset contains raw data on dendrometric measures and processed data on specific wood density (SWD), woody aboveground biomass, and biomass losses through disturbance impacts. Allometric proxies (height, canopy diameters, and in adult trees also stem circumferences) were recorded for n = 6,179 tree and shrub individuals. Wood samples were taken for each encountered species to measure specific wood density. These measurements have been used to estimate woody aboveground biomass via established allometric models, advanced through our improved methodologies and workflows that accounted for tree and shrub architecture shaped by disturbance impacts. To this end, we performed a detailed damage assessment on each woody individual in the field. In addition to estimations of standing biomass, our new method also delivered data on biomass losses to different disturbance agents (elephants, fire, and others) on the level of plant individuals and stands. The data presented here have been used within a study published with Ecological Indicators (Kindermann et al., 2022) to evaluate the benefits of our improved methodology in comparison to a standard reference method of aboveground biomass estimations. Additionally, it has been employed in a study on carbon storage and sequestration in vegetation and soils (Sandhage-Hofmann et al., 2021). The raw data of dendrometric measurements can be subjected to other available allometric models for biomass estimation. The processed data can be used to analyze disturbance impacts on woody aboveground biomass, or for regional carbon storage estimates. The data on species-specific wood density can be used for application to other dendrometric datasets to (re-) estimate biomass through allometric models requiring wood density. It can further be used for plant functional trait analyses.},
  language  = {en}
}
@article{DaempflingMielkeKoellneretal.2022,
  author    = {D{\"a}mpfling, Helge L. C. and Mielke, Christian and Koellner, Nicole and Lorenz, Melanie and Rogass, Christian and Altenberger, Uwe and Harlov, Daniel E. and Knoper, Michael},
  title     = {Automatic element and mineral detection in thin sections using hyperspectral transmittance imaging microscopy (HyperTIM)},
  series = {European journal of mineralogy},
  volume    = {34},
  journal   = {European journal of mineralogy},
  number    = {3},
  publisher = {Copernicus},
  address   = {G{\"o}ttingen},
  issn      = {0935-1221},
  doi       = {10.5194/ejm-34-275-2022},
  pages     = {275 -- 284},
  year      = {2022},
  abstract  = {In this study we present a novel method for the automatic detection of minerals and elements using hyperspectral transmittance imaging microscopy measurements of complete thin sections (HyperTIM). This is accomplished by using a hyperspectral camera system that operates in the visible and near-infrared (VNIR) range with a specifically designed sample holder, scanning setup, and a microscope lens. We utilize this method on a monazite ore thin section from Steenkampskraal (South Africa), which we analyzed for the rare earth element (REE)-bearing mineral monazite ((Ce,Nd,La)PO4), with high concentrations of Nd. The transmittance analyses with the hyperspectral VNIR camera can be used to identify REE minerals and Nd in thin sections. We propose a three-point band depth index, the Nd feature depth index (NdFD), and its related product the Nd band depth index (NdBDI), which enables automatic mineral detection and classification for the Nd-bearing monazites in thin sections. In combination with the average concentration of the relative Nd content, it permits a destruction-free, total concentration calculation for Nd across the entire thin section.},
  language  = {en}
}
@article{WangKuhnGongetal.2021,
  author    = {Wang, Rong and Kuhn, Gerhard and Gong, Xun and Biskaborn, Boris K. and Gersonde, Rainer and Lembke-Jene, Lester and Lohmann, Gerrit and Tiedemann, Ralf and Diekmann, Bernhard},
  title     = {Deglacial land-ocean linkages at the Alaskan continental margin in the Bering Sea},
  series = {Frontiers in Earth Science},
  volume    = {9},
  journal   = {Frontiers in Earth Science},
  publisher = {Frontiers Media},
  address   = {Lausanne},
  issn      = {2296-6463},
  doi       = {10.3389/feart.2021.712415},
  pages     = {16},
  year      = {2021},
  abstract  = {A marine sediment record from the central Bering Sea, spanning the last 20 thousand years (ka), was studied to unravel the depositional history with regard to terrigenous sediment supply and biogenic sedimentation. Methodic approaches comprised the inference of accumulation rates of siliciclastic and biogenic components, grain-size analysis, and (clay) mineralogy, as well as paleoclimatic modelling. Changes in the depositional history provides insight into land-ocean linkages of paleoenvironmental changes. During the finale of the Last Glacial Maximum, the depositional environment was characterized by hemipelagic background sedimentation. A marked change in the terrigenous sediment provenance during the late Heinrich 1 Stadial (15.7-14.5 ka), indicated by increases in kaolinite and a high glaciofluvial influx of clay, gives evidence of the deglaciation of the Brooks Range in the hinterland of Alaska. This meltwater pulse also stimulated the postglacial onset of biological productivity. Glacial melt implies regional climate warming during a time of widespread cooling on the northern hemisphere. Our simulation experiment with a coupled climate model suggests atmospheric teleconnections to the North Atlantic, with impacts on the dynamics of the Aleutian Low system that gave rise to warmer winters and an early onset of spring during that time. The late deglacial period between 14.5 and 11.0 ka was characterized by enhanced fluvial runoff and biological productivity in the course of climate amelioration, sea-level rise, seasonal sea-ice retreat, and permafrost thaw in the hinterland. The latter processes temporarily stalled during the Younger Dryas stadial (12.9-11.7 ka) and commenced again during the Preboreal (earliest Holocene), after 11.7 ka. High river runoff might have fertilized the Bering Sea and contributed to enhanced upper ocean stratification. Since 11.0 ka, advanced transgression has shifted the coast line and fluvial influence of the Yukon River away from the study site. The opening of the Bering Strait strengthened contour currents along the continental slope, leaving behind winnowed sand-rich sediments through the early to mid-Holocene, with non-deposition occurring since about 6.0 ka.},
  language  = {en}
}
@article{CheshmehElahiGhayyemetal.2022,
  author    = {Cheshmeh, Sahar and Elahi, Negin and Ghayyem, Maysa and Mosaieby, Elaheh and Moradi, Shima and Pasdar, Yahya and Tahmasebi, Susan and Moradinazar, Mehdi},
  title     = {Effect of green cardamom on the expression of genes implicated in obesity and diabetes among obese women with polycystic ovary syndrome},
  series = {Genes \& nutrition},
  volume    = {17},
  journal   = {Genes \& nutrition},
  number    = {1},
  publisher = {Springer},
  address   = {Berlin},
  issn      = {1865-3499},
  doi       = {10.1186/s12263-022-00719-6},
  pages     = {11},
  year      = {2022},
  abstract  = {Background: Polycystic ovary syndrome (PCOS) is an endocrine disease in which related to obesity, metabolic disorders and is considered as one of the main causes of infertility in women. This trial was investigated the effects of green cardamom on the expression of genes implicated in obesity and diabetes among obese women with PCOS. Methods: One hundred ninety-four PCOS women were randomly divided two groups: intervention (n = 99; 3 g/day green cardamom) and control groups (n = 95). All of them were given low calorie diet. Anthropometric, glycemic and androgen hormones were assessed before and after 16-week intervention. The reverse transcription-polymerase chain reaction (RT-PCR) method was used to measure fat mass and obesity-associated (FTO), peroxisome proliferative activating receptor- (PPAR-), carnitine palmitoyltransferase 1A (CPT1A), acetyl-CoA carboxylase beta (ACAB), leptin receptor (LEPR), ghrelin, and lamin A/C (LAMIN) genes expression in each group. Results: Anthropometric indices were significantly decreased after intervention in both two studied groups. Glycemic indices and androgen hormones were significantly improved in the intervention group compared to the control group. The expression levels of FTO, CPT1A, LEPR, and LAMIN were significantly downregulated compared to control group (P < 0.001), as well as, PPAR-y was significantly upregulated in the intervention group after intervention with green cardamom compared to control group (P < 0.001). Conclusion: This current study showed that the administration of green cardamom is a beneficial approach for improving anthropometric, glycemic, and androgen hormones, as well as obesity and diabetes genes expression in PCOS women under the low-calorie diet.},
  language  = {en}
}
@article{YarmanKurbanoglu2022,
  author    = {Yarman, Aysu and Kurbanoglu, Sevinc},
  title     = {Molecularly imprinted polymer-based sensors for SARS-CoV-2},
  series = {Biomimetics},
  volume    = {7},
  journal   = {Biomimetics},
  number    = {2},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2313-7673},
  doi       = {10.3390/biomimetics7020058},
  pages     = {17},
  year      = {2022},
  abstract  = {Since the first reported case of COVID-19 in 2019 in China and the official declaration from the World Health Organization in March 2021 as a pandemic, fast and accurate diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has played a major role worldwide. For this reason, various methods have been developed, comprising reverse transcriptase-polymerase chain reaction (RT-PCR), immunoassays, clustered regularly interspaced short palindromic repeats (CRISPR), reverse transcription loop-mediated isothermal amplification (RT-LAMP), and bio(mimetic)sensors. Among the developed methods, RT-PCR is so far the gold standard. Herein, we give an overview of the MIP-based sensors utilized since the beginning of the pandemic.},
  language  = {en}
}
@article{GrzesiukPietrzakWackeretal.2022,
  author    = {Grzesiuk, Malgorzata and Pietrzak, Barbara and Wacker, Alexander and Pijanowska, Joanna},
  title     = {Photosynthetic activity in both algae and cyanobacteria changes in response to cues of predation},
  series = {Frontiers in plant science},
  volume    = {13},
  journal   = {Frontiers in plant science},
  publisher = {Frontiers Media},
  address   = {Lausanne},
  issn      = {1664-462X},
  doi       = {10.3389/fpls.2022.907174},
  pages     = {8},
  year      = {2022},
  abstract  = {A plethora of adaptive responses to predation has been described in microscopic aquatic producers. Although the energetic costs of these responses are expected, with their consequences going far beyond an individual, their underlying molecular and metabolic mechanisms are not fully known. One, so far hardly considered, is if and how the photosynthetic efficiency of phytoplankton might change in response to the predation cues. Our main aim was to identify such responses in phytoplankton and to detect if they are taxon-specific. We exposed seven algae and seven cyanobacteria species to the chemical cues of an efficient consumer, Daphnia magna, which was fed either a green alga, Acutodesmus obliquus, or a cyanobacterium, Synechococcus elongatus (kairomone and alarm cues), or was not fed (kairomone alone). In most algal and cyanobacterial species studied, the quantum yield of photosystem II increased in response to predator fed cyanobacterium, whereas in most of these species the yield did not change in response to predator fed alga. Also, cyanobacteria tended not to respond to a non-feeding predator. The modal qualitative responses of the electron transport rate were similar to those of the quantum yield. To our best knowledge, the results presented here are the broadest scan of photosystem II responses in the predation context so far.},
  language  = {en}
}
@article{LeidigCasaleWilbertetal.2022,
  author    = {Leidig, Tatjana and Casale, Gino and Wilbert, J{\"u}rgen and Hennemann, Thomas and Volpe, Robert J. and Briesch, Amy and Grosche, Michael},
  title     = {Individual, generalized, and moderated effects of the good behavior game on at-risk primary school students},
  series = {Frontiers in Education},
  volume    = {7},
  journal   = {Frontiers in Education},
  publisher = {Frontiers Media},
  address   = {Lausanne},
  issn      = {2504-284X},
  doi       = {10.3389/feduc.2022.917138},
  pages     = {15},
  year      = {2022},
  abstract  = {The current study examined the impact of the Good Behavior Game (GBG) on the academic engagement (AE) and disruptive behavior (DB) of at-risk students' in a German inclusive primary school sample using behavioral progress monitoring. A multiple baseline design across participants was employed to evaluate the effects of the GBG on 35 primary school students in seven classrooms from grade 1 to 3 (M-age = 8.01 years, SDage = 0.81 years). The implementation of the GBG was randomly staggered by 2 weeks across classrooms. Teacher-completed Direct Behavior Rating (DBR) was applied to measure AE and DB. We used piecewise regression and a multilevel extension to estimate the individual case-specific treatment effects as well as the generalized effects across cases. Piecewise regressions for each case showed significant immediate treatment effects for the majority of participants (82.86\%) for one or both outcome measures. The multilevel approach revealed that the GBG improved at-risk students' classroom behaviors generally with a significant immediate treatment effect across cases (for AE, B = 0.74, p < 0.001; for DB, B = -1.29, p < 0.001). The moderation between intervention effectiveness and teacher ratings of students' risks for externalizing psychosocial problems was significant for DB (B = -0.07, p = 0.047) but not for AE. Findings are consistent with previous studies indicating that the GBG is an appropriate classroom-based intervention for at-risk students and expand the literature regarding differential effects for affected students. In addition, the study supports the relevance of behavioral progress monitoring and data-based decision-making in inclusive schools in order to evaluate the effectiveness of the GBG and, if necessary, to modify the intervention for individual students or the whole group.},
  language  = {en}
}
@article{KnappAttingerHuth2022,
  author    = {Knapp, Nikolai and Attinger, Sabine and Huth, Andreas},
  title     = {A question of scale: modeling biomass, gain and mortality distributions of a tropical forest},
  series = {Biogeosciences},
  volume    = {19},
  journal   = {Biogeosciences},
  number    = {20},
  publisher = {Copernicus},
  address   = {Katlenburg-Lindau [u.a.]},
  issn      = {1726-4170},
  doi       = {10.5194/bg-19-4929-2022},
  pages     = {4929 -- 4944},
  year      = {2022},
  abstract  = {Describing the heterogeneous structure of forests is often challenging. One possibility is to analyze forest biomass in different plots and to derive plot-based frequency distributions. However, these frequency distributions depend on the plot size and thus are scale dependent. This study provides insights about transferring them between scales. Understanding the effects of scale on distributions of biomass is particularly important for comparing information from different sources such as inventories, remote sensing and modeling, all of which can operate at different spatial resolutions. Reliable methods to compare results of vegetation models at a grid scale with field data collected at smaller scales are still missing. The scaling of biomass and variables, which determine the forest biomass, was investigated for a tropical forest in Panama. Based on field inventory data from Barro Colorado Island, spanning 50 ha over 30 years, the distributions of aboveground biomass, biomass gain and mortality were derived at different spatial resolutions, ranging from 10 to 100 m. Methods for fitting parametric distribution functions were compared. Further, it was tested under which assumptions about the distributions a simple stochastic simulation forest model could best reproduce observed biomass distributions at all scales. Also, an analytical forest model for calculating biomass distributions at equilibrium and assuming mortality as a white shot noise process was tested. Scaling exponents of about 0.47 were found for the standard deviations of the biomass and gain distributions, while mortality showed a different scaling relationship with an exponent of 0.3. Lognormal and gamma distribution functions fitted with the moment matching estimation method allowed for consistent parameter transfers between scales. Both forest models (stochastic simulation and analytical solution) were able to reproduce observed biomass distributions across scales, when combined with the derived scaling relationships. The study demonstrates a way of how to approach the scaling problem in model-data comparisons by providing a transfer relationship. Further research is needed for a better understanding of the mechanisms that shape the frequency distributions at the different scales.},
  language  = {en}
}
@article{ShoghiArslanBastiaanseetal.2022,
  author    = {Shoghi, Sara and Arslan, Seckin and Bastiaanse, Roelien and Popov, Srdan},
  title     = {Does a walk-through video help the parser down the garden-path?},
  series = {Frontiers in psychology},
  volume    = {13},
  journal   = {Frontiers in psychology},
  publisher = {Frontiers Media},
  address   = {Lausanne},
  issn      = {1664-1078},
  doi       = {10.3389/fpsyg.2022.1009265},
  pages     = {14},
  year      = {2022},
  abstract  = {The human language processing mechanism assigns a structure to the incoming materials as they unfold. There is evidence that the parser prefers some attachment types over others; however, theories of sentence processing are still in dispute over the stage at which each source of information contributes to the parsing system. The present study aims to identify the nature of initial parsing decisions during sentence processing through manipulating attachment type and verbs' argument structure. To this end, we designed a self-paced reading task using globally ambiguous constructions in Dutch. The structures included double locative prepositional phrases (PPs) where the first PP could attach both to the verb (high attachment) and the noun preceding it (low attachment). To disambiguate the structures, we presented a visual context in the form of short animation clips prior to each reading task. Furthermore, we manipulated the argument structure of the sentences using 2- and 3-argument verbs. The results showed that parsing decisions were influenced by contextual cues depending on the argument structure of the verb. That is, the visual context overcame the preference for high attachment only in the case of 2-argument verbs, while this preference persisted in structures including 3-argument verbs as represented by longer reading times for the low attachment interpretations. These findings can be taken as evidence that our language processing system actively integrates information from linguistic and non-linguistic sources from the initial stages of analysis to build up meaning. We discuss our findings in light of serial and parallel models of sentence processing.},
  language  = {en}
}
@article{WerfelliHammamiSelmietal.2021,
  author    = {Werfelli, Hanen and Hammami, Raouf and Selmi, Mohamed Amine and Selmi, Walid and Gabrilo, Goran and Clark, Cain C. T. and Duncan, Michael and Sekulic, Damir and Granacher, Urs and Rebai, Haithem},
  title     = {Acute Effects of Different Plyometric and Strength Exercises on Balance Performance in Youth Weightlifters},
  series = {Frontiers in Physiology},
  volume    = {12},
  journal   = {Frontiers in Physiology},
  publisher = {Frontiers Research Foundation},
  address   = {Lausanne},
  issn      = {1664-042X},
  doi       = {10.3389/fphys.2021.716981},
  pages     = {9},
  year      = {2021},
  abstract  = {Background: High-intensity muscle actions have the potential to temporarily improve the performance which has been denoted as postactivation performance enhancement. Objectives: This study determined the acute effects of different stretch-shortening (fast vs. low) and strength (dynamic vs. isometric) exercises executed during one training session on subsequent balance performance in youth weightlifters. Materials and Methods: Sixteen male and female young weightlifters, aged 11.3±0.6years, performed four strength exercise conditions in randomized order, including dynamic strength (DYN; 3 sets of 3 repetitions of 10 RM) and isometric strength exercises (ISOM; 3 sets of maintaining 3s of 10 RM of back-squat), as well as fast (FSSC; 3 sets of 3 repetitions of 20-cm drop-jumps) and slow (SSSC; 3 sets of 3 hurdle jumps over a 20-cm obstacle) stretch-shortening cycle protocols. Balance performance was tested before and after each of the four exercise conditions in bipedal stance on an unstable surface (i.e., BOSU ball with flat side facing up) using two dependent variables, i.e., center of pressure surface area (CoP SA) and velocity (CoP V). Results: There was a significant effect of time on CoP SA and CoP V [F(1,60)=54.37, d=1.88, p<0.0001; F(1,60)=9.07, d=0.77, p=0.003]. In addition, a statistically significant effect of condition on CoP SA and CoP V [F(3,60)=11.81, d=1.53, p<0.0001; F(3,60)=7.36, d=1.21, p=0.0003] was observed. Statistically significant condition-by-time interactions were found for the balance parameters CoP SA (p<0.003, d=0.54) and CoP V (p<0.002, d=0.70). Specific to contrast analysis, all specified hypotheses were tested and demonstrated that FSSC yielded significantly greater improvements than all other conditions in CoP SA and CoP V [p<0.0001 (d=1.55); p=0.0004 (d=1.19), respectively]. In addition, FSSC yielded significantly greater improvements compared with the two conditions for both balance parameters [p<0.0001 (d=2.03); p<0.0001 (d=1.45)]. Conclusion: Fast stretch-shortening cycle exercises appear to be more effective to improve short-term balance performance in young weightlifters. Due to the importance of balance for overall competitive achievement in weightlifting, it is recommended that young weightlifters implement dynamic plyometric exercises in the fast stretch-shortening cycle during the warm-up to improve their balance performance.},
  language  = {en}
}
@article{DelfanJuybariGorganiFiruzjaeeetal.2022,
  author    = {Delfan, Maryam and Juybari, Raheleh Amadeh and Gorgani-Firuzjaee, Sattar and Nielsen, Jens H{\o}iriis and Delfan, Neda and Laher, Ismail and Saeidi, Ayoub and Granacher, Urs and Zouhal, Hassane},
  title     = {High-Intensity Interval Training Improves Cardiac Function by miR-206 Dependent HSP60 Induction in Diabetic Rats},
  series = {Frontiers in Cardiovascular Medicine},
  volume    = {9},
  journal   = {Frontiers in Cardiovascular Medicine},
  publisher = {Frontiers},
  address   = {Lausanne, Schweiz},
  issn      = {2297-055X},
  doi       = {10.3389/fcvm.2022.927956},
  pages     = {1 -- 11},
  year      = {2022},
  abstract  = {Objective: A role for microRNAs is implicated in several biological and pathological processes. We investigated the effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on molecular markers of diabetic cardiomyopathy in rats. Methods: Eighteen male Wistar rats (260 ± 10 g; aged 8 weeks) with streptozotocin (STZ)-induced type 1 diabetes mellitus (55 mg/kg, IP) were randomly allocated to three groups: control, MICT, and HIIT. The two different training protocols were performed 5 days each week for 5 weeks. Cardiac performance (end-systolic and end-diastolic dimensions, ejection fraction), the expression of miR-206, HSP60, and markers of apoptosis (cleaved PARP and cytochrome C) were determined at the end of the exercise interventions. Results: Both exercise interventions (HIIT and MICT) decreased blood glucose levels and improved cardiac performance, with greater changes in the HIIT group (p < 0.001, η2: 0.909). While the expressions of miR-206 and apoptotic markers decreased in both training protocols (p < 0.001, η2: 0.967), HIIT caused greater reductions in apoptotic markers and produced a 20\% greater reduction in miR-206 compared with the MICT protocol (p < 0.001). Furthermore, both training protocols enhanced the expression of HSP60 (p < 0.001, η2: 0.976), with a nearly 50\% greater increase in the HIIT group compared with MICT. Conclusions: Our results indicate that both exercise protocols, HIIT and MICT, have the potential to reduce diabetic cardiomyopathy by modifying the expression of miR-206 and its downstream targets of apoptosis. It seems however that HIIT is even more effective than MICT to modulate these molecular markers.},
  language  = {en}
}
@article{RazaghiMoghadamSokolowskaSowaetal.2021,
  author    = {Razaghi-Moghadam, Zahra and Sokolowska, Ewelina and Sowa, Marcin A. and Skirycz, Aleksandra and Nikoloski, Zoran},
  title     = {Combination of network and molecule structure accurately predicts competitive inhibitory interactions},
  series = {Computational and structural biotechnology journal},
  volume    = {19},
  journal   = {Computational and structural biotechnology journal},
  publisher = {Research Network of Computational and Structural Biotechnology (RNCSB)},
  address   = {Gotenburg},
  issn      = {2001-0370},
  doi       = {10.1016/j.csbj.2021.04.012},
  pages     = {2170 -- 2178},
  year      = {2021},
  abstract  = {Mining of metabolite-protein interaction networks facilitates the identification of design principles underlying the regulation of different cellular processes. However, identification and characterization of the regulatory role that metabolites play in interactions with proteins on a genome-scale level remains a pressing task. Based on availability of high-quality metabolite-protein interaction networks and genome-scale metabolic networks, here we propose a supervised machine learning approach, called CIRI that determines whether or not a metabolite is involved in a competitive inhibitory regulatory interaction with an enzyme. First, we show that CIRI outperforms the naive approach based on a structural similarity threshold for a putative competitive inhibitor and the substrates of a metabolic reaction. We also validate the performance of CIRI on several unseen data sets and databases of metabolite-protein interactions not used in the training, and demonstrate that the classifier can be effectively used to predict competitive inhibitory interactions. Finally, we show that CIRI can be employed to refine predictions about metabolite-protein interactions from a recently proposed PROMIS approach that employs metabolomics and proteomics profiles from size exclusion chromatography in E. coli to predict metaboliteprotein interactions. Altogether, CIRI fills a gap in cataloguing metabolite-protein interactions and can be used in directing future machine learning efforts to categorize the regulatory type of these interactions.},
  language  = {en}
}
@article{WiesmeierDalinWehrleetal.2017,
  author    = {Wiesmeier, Isabella K. and Dalin, Daniela and Wehrle, Anja and Granacher, Urs and Muehlbauer, Thomas and Dietterle, J{\"o}rg and Weiller, Cornelius and Gollhofer, Albert and Maurer, Christoph},
  title     = {Balance training enhances vestibular function and reduces overactive proprioceptive feedback in elderly},
  series = {Frontiers in aging neuroscience},
  volume    = {9},
  journal   = {Frontiers in aging neuroscience},
  publisher = {Frontiers Research Foundation},
  address   = {Lausanne},
  issn      = {1663-4365},
  doi       = {10.3389/fnagi.2017.00273},
  pages     = {13},
  year      = {2017},
  abstract  = {Objectives: Postural control in elderly people is impaired by degradations of sensory, motor, and higher-level adaptive mechanisms. Here, we characterize the effects of a progressive balance training programon these postural control impairments using a brain network model based on system identification techniques. Methods and Material: We analyzed postural control of 35 healthy elderly subjects and compared findings to data from 35 healthy young volunteers. Eighteen elderly subjects performed a 10 week balance training conducted twice per week. Balance training was carried out in static and dynamic movement states, on support surfaces with different elastic compliances, under different visual conditions and motor tasks. Postural control was characterized by spontaneous sway and postural reactions to pseudorandom anterior-posterior tilts of the support surface. Data were interpreted using a parameter identification procedure based on a brain network model. Conclusion: Balance training reduced overactive proprioceptive feedback and restored vestibular orientation in elderly. Based on the assumption of a linear deterioration of postural control across the life span, the training effect can be extrapolated as a juvenescence of 10 years. This study points to a considerable benefit of a continuous balance training in elderly, even without any sensorimotor deficits.},
  language  = {en}
}
@article{SaidiBenAbderrahmanBoullosaetal.2020,
  author    = {Saidi, Karim and Ben Abderrahman, Abderraouf and Boullosa, Daniel and Dupont, Gr{\´e}gory and Hackney, Anthony C. and Bideau, Benoit and Pavillon, Thomas and Granacher, Urs and Zouhal, Hassane},
  title     = {The Interplay Between Plasma Hormonal Concentrations, Physical Fitness, Workload and Mood State Changes to Periods of Congested Match Play in Professional Soccer Players},
  series = {Frontiers in Physiology},
  volume    = {11},
  journal   = {Frontiers in Physiology},
  publisher = {Frontiers Research Foundation},
  address   = {Lausanne},
  issn      = {1664-042X},
  doi       = {10.3389/fphys.2020.00835},
  pages     = {14},
  year      = {2020},
  abstract  = {Background: The regular assessment of hormonal and mood state parameters in professional soccer are proposed as good indicators during periods of intense training and/or competition to avoid overtraining. Objective: The aim of this study was to analyze hormonal, psychological, workload and physical fitness parameters in elite soccer players in relation to changes in training and match exposure during a congested period of match play. Methods: Sixteen elite soccer players from a team playing in the first Tunisian soccer league were evaluated three times (T1, T2, and T3) over 12 weeks. The non-congested period of match play was from T1 to T2, when the players played 6 games over 6 weeks. The congested period was from T2 to T3, when the players played 10 games over 6 weeks. From T1 to T3, players performed the Yo-Yo intermittent recovery test level 1 (YYIR1), the repeated shuttle sprint ability test (RSSA), the countermovement jump test (CMJ), and the squat jump test (SJ). Plasma Cortisol (C), Testosterone (T), and the T/C ratio were analyzed at T1, T2, and T3. Players had their mood dimensions (tension, depression, anger, vigor, fatigue, confusion, and a Total Mood Disturbance) assessed through the Profile of Mood State questionnaire (POMS). Training session rating of perceived exertion (sRPE) was also recorded on a daily basis in order to quantify internal training load and elements of monotony and strain. Results: Significant performance declines (T1 < T2 < T3) were found for SJ performance (p = 0.04, effect size [ES] ES₁₋₂ = 0.15-0.06, ES₂₋₃ = 0.24) from T1 to T3. YYIR1 performance improved significantly from T1 to T2 and declined significantly from T2 to T3 (p = 0.001, ES₁₋₂ = 0.24, ES₂₋₃ = -2.54). Mean RSSA performance was significantly higher (p = 0.019, ES₁₋₂ = -0.47, ES₂₋₃ = 1.15) in T3 compared with T2 and T1. Best RSSA performance was significantly higher in T3 when compared with T2 and T1 (p = 0.006, ES₂₋₃ = 0.47, ES₁₋₂ = -0.56), but significantly lower in T2 when compared with to T1. T and T/C were significantly lower in T3 when compared with T2 and T1 (T: p = 0.03, ES₃₋₂ = -0.51, ES₃₋₁ = -0.51, T/C: p = 0.017, ES₃₋₂ = -1.1, ES₃₋₁ = -1.07). Significant decreases were found for the vigor scores in T3 when compared to T2 and T1 (p = 0.002, ES₁₋₂ = 0.31, ES₃₋₂ = -1.25). A significant increase was found in fatigue scores in T3 as compared to T1 and T2 (p = 0.002, ES₁₋₂ = 0.43, ES₂₋₃ = 0.81). A significant increase was found from T1 < T2 < T3 intension score (p = 0.002, ES₁₋₂ = 1.1, ES₂₋₃ = 0.2) and anger score (p = 0.03, ES₁₋₂ = 0.47, ES₂₋₃ = 0.33) over the study period. Total mood disturbance increased significantly (p = 0.02, ES₁₋₂ = 0.91, ES₂₋₃ = 1.1) from T1 to T3. Between T1-T2, significant relationships were observed between workload and changes in T (r = 0.66, p = 0.003), and T/C ratio (r = 0.62, p = 0.01). There were significant relationships between performance in RSSAbest and training load parameters (workload: r = 0.52, p = 0.03; monotony: r = 0.62, p = 0.01; strain: r = 0.62, p = 0.009). Between T2-T3, there was a significant relationship between Δ\% of total mood disturbance and Δ\% of YYIR1 (r = -0.54; p = 0.04), RSSAbest (r = 0.58, p = 0.01), SJ (r = -0,55, p = 0.01), T (r = 0.53; p = 0.03), and T/C (r = 0.5; p = 0.04). Conclusion: An intensive period of congested match play significantly compromised elite soccer players' physical and mental fitness. These changes were related to psychological but not hormonal parameters; even though significant alterations were detected for selected measures. Mood monitoring could be a simple and useful tool to determine the degree of preparedness for match play during a congested period in professional soccer.},
  language  = {en}
}
@article{HomolkaPryba2024,
  author    = {Homolka, Walter and Pryba, Andrzej},
  title     = {Preparations for marriage in the Jewish and Catholic traditions},
  series = {Religions},
  volume    = {15},
  journal   = {Religions},
  number    = {62},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2077-1444},
  doi       = {https://doi.org/10.3390/rel15010062},
  pages     = {1 -- 14},
  year      = {2024},
  abstract  = {In many churches nowadays, there has been a standardized approach to premarital counseling for couples involving social, pastoral, and psychological perspectives. In contrast, many rabbis and other Jewish officials still concentrate on legal aspects alone. The need for resolving important issues on the verge of wedlock is too often left to secular experts in law, psychology, or counseling. However, in recent years, this lack of formal training for marriage preparation has also been acknowledged by the Jewish clergy in order to incorporate it in the preparatory period before the bond is tied. This case study focuses on Jewish and Roman Catholic conceptions of marriage, past and present. We intend to do a comparative analysis of the prerequisites of religious marriage based on the assumption that both Judaism and the Roman Catholic Church have a distinct legal framework to assess marriage preparation.},
  language  = {en}
}
@article{ScharnweberAnderssonChaguacedaetal.2021,
  author    = {Scharnweber, Inga Kristin and Andersson, Matilda L. and Chaguaceda, Fernando and Ekl{\"o}v, Peter},
  title     = {Intraspecific differences in metabolic rates shape carbon stable isotope trophic discrimination factors of muscle tissue in the common teleost Eurasian perch (Perca fluviatilis)},
  series = {Ecology and evolution},
  volume    = {11},
  journal   = {Ecology and evolution},
  number    = {14},
  publisher = {John Wiley \& Sons, Inc.},
  address   = {New Jersey},
  issn      = {2045-7758},
  doi       = {10.1002/ece3.7809},
  pages     = {9804 -- 9814},
  year      = {2021},
  abstract  = {Stable isotopes represent a unique approach to provide insights into the ecology of organisms. δ13C and δ15N have specifically been used to obtain information on the trophic ecology and food-web interactions. Trophic discrimination factors (TDF, Δ13C and Δ15N) describe the isotopic fractionation occurring from diet to consumer tissue, and these factors are critical for obtaining precise estimates within any application of δ13C and δ15N values. It is widely acknowledged that metabolism influences TDF, being responsible for different TDF between tissues of variable metabolic activity (e.g., liver vs. muscle tissue) or species body size (small vs. large). However, the connection between the variation of metabolism occurring within a single species during its ontogeny and TDF has rarely been considered. Here, we conducted a 9-month feeding experiment to report Δ13C and Δ15N of muscle and liver tissues for several weight classes of Eurasian perch (Perca fluviatilis), a widespread teleost often studied using stable isotopes, but without established TDF for feeding on a natural diet. In addition, we assessed the relationship between the standard metabolic rate (SMR) and TDF by measuring the oxygen consumption of the individuals. Our results showed a significant negative relationship of SMR with Δ13C, and a significant positive relationship of SMR with Δ15N of muscle tissue, but not with TDF of liver tissue. SMR varies inversely with size, which translated into a significantly different TDF of muscle tissue between size classes. In summary, our results emphasize the role of metabolism in shaping-specific TDF (i.e., Δ13C and Δ15N of muscle tissue) and especially highlight the substantial differences between individuals of different ontogenetic stages within a species. Our findings thus have direct implications for the use of stable isotope data and the applications of stable isotopes in food-web studies.},
  language  = {en}
}
@article{LeverMayerMetjeetal.2021,
  author    = {Lever, Fabiano and Mayer, Dennis and Metje, Jan and Alisauskas, Skirmantas and Calegari, Francesca and D{\"u}sterer, Stefan and Feifel, Raimund and Niebuhr, Mario and Manschwetus, Bastian and Kuhlmann, Marion and Mazza, Tommaso and Robinson, Matthew Scott and Squibb, Richard J. and Trabattoni, Andrea and Wallner, M{\aa}ns and Wolf, Thomas J. A. and G{\"u}hr, Markus},
  title     = {Core-level spectroscopy of 2-thiouracil at the sulfur L1 and L2,3 edges utilizing a SASE free-electron-laser},
  series = {Molecules},
  volume    = {26},
  journal   = {Molecules},
  number    = {21},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {1420-3049},
  doi       = {10.3390/molecules26216469},
  pages     = {11},
  year      = {2021},
  abstract  = {In this paper, we report X-ray absorption and core-level electron spectra of the nucleobase derivative 2-thiouracil at the sulfur L1- and L2,3-edges. We used soft X-rays from the free-electron laser FLASH2 for the excitation of isolated molecules and dispersed the outgoing electrons with a magnetic bottle spectrometer. We identified photoelectrons from the 2p core orbital, accompanied by an electron correlation satellite, as well as resonant and non-resonant Coster-Kronig and Auger-Meitner emission at the L1- and L2,3-edges, respectively. We used the electron yield to construct X-ray absorption spectra at the two edges. The experimental data obtained are put in the context of the literature currently available on sulfur core-level and 2-thiouracil spectroscopy.},
  language  = {en}
}
@article{DechBittmannSchaefer2021,
  author    = {Dech, Silas and Bittmann, Frank and Schaefer, Laura},
  title     = {Muscle oxygenation level might trigger the regulation of capillary venous blood filling during fatiguing isometric muscle actions},
  series = {Diagnostics},
  volume    = {11},
  journal   = {Diagnostics},
  number    = {11},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2075-4418},
  doi       = {10.3390/diagnostics11111973},
  pages     = {17},
  year      = {2021},
  abstract  = {The regulation of oxygen and blood supply during isometric muscle actions is still unclear. Recently, two behavioral types of oxygen saturation (SvO2) and relative hemoglobin amount (rHb) in venous microvessels were described during a fatiguing holding isometric muscle action (HIMA) (type I: nearly parallel behavior of SvO2 and rHb; type II: partly inverse behavior). The study aimed to ascertain an explanation of these two regulative behaviors. Twelve subjects performed one fatiguing HIMA trial with each arm by weight holding at 60\% of the maximal voluntary isometric contraction (MVIC) in a 90° elbow flexion. Six subjects additionally executed one fatiguing PIMA trial by pulling on an immovable resistance with 60\% of the MVIC with each side and same position. Both regulative types mentioned were found during HIMA (I: n = 7, II: n = 17) and PIMA (I: n = 3, II: n = 9). During the fatiguing measurements, rHb decreased initially and started to increase in type II at an average SvO2-level of 58.75 ± 2.14\%. In type I, SvO2 never reached that specific value during loading. This might indicate the existence of a threshold around 59\% which seems to trigger the increase in rHb and could explain the two behavioral types. An approach is discussed to meet the apparent incompatibility of an increased capillary blood filling (rHb) despite high intramuscular pressures which were found by other research groups during isometric muscle actions.},
  language  = {en}
}
@article{KabothBahrBahrStepaneketal.2021,
  author    = {Kaboth-Bahr, Stefanie and Bahr, Andr{\´e} and Stepanek, Christian and Catunda, Maria Carolina Amorim and Karas, Cyrus and Ziegler, Martin and Garc{\´i}a-Gallardo, {\´A}ngela and Grunert, Patrick},
  title     = {Mediterranean heat injection to the North Atlantic delayed the intensification of Northern Hemisphere glaciations},
  series = {Communications Earth \& Environment},
  journal   = {Communications Earth \& Environment},
  publisher = {Springer Nature},
  address   = {London},
  issn      = {2662-4435},
  doi       = {10.1038/s43247-021-00232-5},
  pages     = {1 -- 9},
  year      = {2021},
  abstract  = {The intensification of Northern Hemisphere glaciations at the end of the Pliocene epoch marks one of the most substantial climatic shifts of the Cenozoic. Despite global cooling, sea surface temperatures in the high latitude North Atlantic Ocean rose between 2.9-2.7 million years ago. Here we present sedimentary geochemical proxy data from the Gulf of Cadiz to reconstruct the variability of Mediterranean Outflow Water, an important heat source to the North Atlantic. We find evidence for enhanced production of Mediterranean Outflow from the mid-Pliocene to the late Pliocene which we infer could have driven a sub-surface heat channel into the high-latitude North Atlantic. We then use Earth System Models to constrain the impact of enhanced Mediterranean Outflow production on the northward heat transport in the North Atlantic. In accord with the proxy data, the numerical model results support the formation of a sub-surface channel that pumped heat from the subtropics into the high latitude North Atlantic. We further suggest that this mechanism could have delayed ice sheet growth at the end of the Pliocene.},
  language  = {en}
}
@article{SeeligRisseEngbert2021,
  author    = {Seelig, Stefan and Risse, Sarah and Engbert, Ralf},
  title     = {Predictive modeling of parafoveal information processing during reading},
  series = {Scientific Reports},
  volume    = {11},
  journal   = {Scientific Reports},
  publisher = {Springer Nature},
  address   = {Berlin},
  issn      = {2045-2322},
  doi       = {10.1038/s41598-021-92140-z},
  pages     = {9},
  year      = {2021},
  abstract  = {Skilled reading requires information processing of the fixated and the not-yet-fixated words to generate precise control of gaze. Over the last 30 years, experimental research provided evidence that word processing is distributed across the perceptual span, which permits recognition of the fixated (foveal) word as well as preview of parafoveal words to the right of fixation. However, theoretical models have been unable to differentiate the specific influences of foveal and parafoveal information on saccade control. Here we show how parafoveal word difficulty modulates spatial and temporal control of gaze in a computational model to reproduce experimental results. In a fully Bayesian framework, we estimated model parameters for different models of parafoveal processing and carried out large-scale predictive simulations and model comparisons for a gaze-contingent reading experiment. We conclude that mathematical modeling of data from gaze-contingent experiments permits the precise identification of pathways from parafoveal information processing to gaze control, uncovering potential mechanisms underlying the parafoveal contribution to eye-movement control.},
  language  = {en}
}
@article{MusculusTuenteRaabetal.2021,
  author    = {Musculus, Lisa and T{\"u}nte, Markus R. and Raab, Markus and Kayhan, Ezgi},
  title     = {An embodied cognition perspective on the role of interoception in the development of the minimal self},
  series = {Frontiers in Psychology},
  volume    = {12},
  journal   = {Frontiers in Psychology},
  publisher = {Frontiers Research Foundation},
  address   = {Lausanne},
  issn      = {1664-1078},
  doi       = {10.3389/fpsyg.2021.716950},
  pages     = {7},
  year      = {2021},
  abstract  = {Interoception is an often neglected but crucial aspect of the human minimal self. In this perspective, we extend the embodiment account of interoceptive inference to explain the development of the minimal self in humans. To do so, we first provide a comparative overview of the central accounts addressing the link between interoception and the minimal self. Grounding our arguments on the embodiment framework, we propose a bidirectional relationship between motor and interoceptive states, which jointly contribute to the development of the minimal self. We present empirical findings on interoception in development and discuss the role of interoception in the development of the minimal self. Moreover, we make theoretical predictions that can be tested in future experiments. Our goal is to provide a comprehensive view on the mechanisms underlying the minimal self by explaining the role of interoception in the development of the minimal self.},
  language  = {en}
}
@article{JulienMatthiasSaynischWagneretal.2022,
  author    = {Julien, B{\"a}renzung and Matthias, Holschneider and Saynisch-Wagner, Jan and Thomas, Maik},
  title     = {Kalmag: a high spatio-temporal model of the geomagnetic field},
  series = {Earth, planets and space},
  volume    = {74},
  journal   = {Earth, planets and space},
  number    = {1},
  publisher = {Springer},
  address   = {New York},
  issn      = {1880-5981},
  doi       = {10.1186/s40623-022-01692-5},
  pages     = {22},
  year      = {2022},
  abstract  = {We present the extension of the Kalmag model, proposed as a candidate for IGRF-13, to the twentieth century. The dataset serving its derivation has been complemented by new measurements coming from satellites, ground-based observatories and land, marine and airborne surveys. As its predecessor, this version is derived from a combination of a Kalman filter and a smoothing algorithm, providing mean models and associated uncertainties. These quantities permit a precise estimation of locations where mean solutions can be considered as reliable or not. The temporal resolution of the core field and the secular variation was set to 0.1 year over the 122 years the model is spanning. Nevertheless, it can be shown through ensembles a posteriori sampled, that this resolution can be effectively achieved only by a limited amount of spatial scales and during certain time periods. Unsurprisingly, highest accuracy in both space and time of the core field and the secular variation is achieved during the CHAMP and Swarm era. In this version of Kalmag, a particular effort was made for resolving the small-scale lithospheric field. Under specific statistical assumptions, the latter was modeled up to spherical harmonic degree and order 1000, and signal from both satellite and survey measurements contributed to its development. External and induced fields were jointly estimated with the rest of the model. We show that their large scales could be accurately extracted from direct measurements whenever the latter exhibit a sufficiently high temporal coverage. Temporally resolving these fields down to 3 hours during the CHAMP and Swarm missions, gave us access to the link between induced and magnetospheric fields. In particular, the period dependence of the driving signal on the induced one could be directly observed. The model is available through various physical and statistical quantities on a dedicated website at https://ionocovar.agnld.uni-potsdam.de/Kalmag/.},
  language  = {en}
}
@article{CahsanKiemelWestburyetal.2021,
  author    = {Cahsan, Binia De and Kiemel, Katrin and Westbury, Michael V. and Lauritsen, Maike and Autenrieth, Marijke and Gollmann, G{\"u}nter and Schweiger, Silke and Stenberg, Marika and Nystr{\"o}m, Per and Drews, Hauke and Tiedemann, Ralph},
  title     = {Southern introgression increases adaptive immune gene variability in northern range margin populations of Fire-bellied toad},
  series = {Ecology and Evolution},
  volume    = {11},
  journal   = {Ecology and Evolution},
  number    = {14},
  publisher = {John Wiley \& Sons, Inc.},
  address   = {New Jersey},
  issn      = {2045-7758},
  doi       = {10.1002/ece3.7805},
  pages     = {15},
  year      = {2021},
  abstract  = {Northern range margin populations of the European fire-bellied toad (Bombina bombina) have rapidly declined during recent decades. Extensive agricultural land use has fragmented the landscape, leading to habitat disruption and loss, as well as eutrophication of ponds. In Northern Germany (Schleswig-Holstein) and Southern Sweden (Sk{\aa}ne), this population decline resulted in decreased gene flow from surrounding populations, low genetic diversity, and a putative reduction in adaptive potential, leaving populations vulnerable to future environmental and climatic changes. Previous studies using mitochondrial control region and nuclear transcriptome-wide SNP data detected introgressive hybridization in multiple northern B. bombina populations after unreported release of toads from Austria. Here, we determine the impact of this introgression by comparing the body conditions (proxy for fitness) of introgressed and nonintrogressed populations and the genetic consequences in two candidate genes for putative local adaptation (the MHC II gene as part of the adaptive immune system and the stress response gene HSP70 kDa). We detected regional differences in body condition and observed significantly elevated levels of within individual MHC allele counts in introgressed Swedish populations, associated with a tendency toward higher body weight, relative to regional nonintrogressed populations. These differences were not observed among introgressed and nonintrogressed German populations. Genetic diversity in both MHC and HSP was generally lower in northern than Austrian populations. Our study sheds light on the potential benefits of translocations of more distantly related conspecifics as a means to increase adaptive genetic variability and fitness of genetically depauperate range margin populations without distortion of local adaptation.},
  language  = {en}
}
@article{MalchowBocediPalmeretal.2021,
  author    = {Malchow, Anne-Kathleen and Bocedi, Greta and Palmer, Stephen C. F. and Travis, Justin M. J. and Zurell, Damaris},
  title     = {RangeShiftR: an R package for individual-based simulation of spatial eco-evolutionary dynamics and speciesu0027 responses to environmental changes},
  series = {Ecography},
  volume    = {44},
  journal   = {Ecography},
  number    = {10},
  publisher = {John Wiley \& Sons, Inc.},
  address   = {New Jersey},
  issn      = {1600-0587},
  doi       = {10.1111/ecog.05689},
  pages     = {10},
  year      = {2021},
  abstract  = {Reliably modelling the demographic and distributional responses of a species to environmental changes can be crucial for successful conservation and management planning. Process-based models have the potential to achieve this goal, but so far they remain underused for predictions of species' distributions. Individual-based models offer the additional capability to model inter-individual variation and evolutionary dynamics and thus capture adaptive responses to environmental change. We present RangeShiftR, an R implementation of a flexible individual-based modelling platform which simulates eco-evolutionary dynamics in a spatially explicit way. The package provides flexible and fast simulations by making the software RangeShifter available for the widely used statistical programming platform R. The package features additional auxiliary functions to support model specification and analysis of results. We provide an outline of the package's functionality, describe the underlying model structure with its main components and present a short example. RangeShiftR offers substantial model complexity, especially for the demographic and dispersal processes. It comes with elaborate tutorials and comprehensive documentation to facilitate learning the software and provide help at all levels. As the core code is implemented in C++, the computations are fast. The complete source code is published under a public licence, making adaptations and contributions feasible. The RangeShiftR package facilitates the application of individual-based and mechanistic modelling to eco-evolutionary questions by operating a flexible and powerful simulation model from R. It allows effortless interoperation with existing packages to create streamlined workflows that can include data preparation, integrated model specification and results analysis. Moreover, the implementation in R strengthens the potential for coupling RangeShiftR with other models.},
  language  = {en}
}
@article{CahsanWestburyParaskevopoulouetal.2021,
  author    = {Cahsan, Binia De and Westbury, Michael V. and Paraskevopoulou, Sofia and Drews, Hauke and Ott, Moritz and Gollmann, G{\"u}nter and Tiedemann, Ralph},
  title     = {Genomic consequences of human-mediated translocations in margin populations of an endangered amphibian},
  series = {Evolutionary Applications},
  volume    = {14},
  journal   = {Evolutionary Applications},
  number    = {6},
  publisher = {John Wiley \& Sons, Inc.},
  address   = {New Jersey},
  issn      = {1752-4563},
  doi       = {10.1111/eva.13229},
  pages     = {12},
  year      = {2021},
  abstract  = {Due to their isolated and often fragmented nature, range margin populations are especially vulnerable to rapid environmental change. To maintain genetic diversity and adaptive potential, gene flow from disjunct populations might therefore be crucial to their survival. Translocations are often proposed as a mitigation strategy to increase genetic diversity in threatened populations. However, this also includes the risk of losing locally adapted alleles through genetic swamping. Human-mediated translocations of southern lineage specimens into northern German populations of the endangered European fire-bellied toad (Bombina bombina) provide an unexpected experimental set-up to test the genetic consequences of an intraspecific introgression from central population individuals into populations at the species range margin. Here, we utilize complete mitochondrial genomes and transcriptome nuclear data to reveal the full genetic extent of this translocation and the consequences it may have for these populations. We uncover signs of introgression in four out of the five northern populations investigated, including a number of introgressed alleles ubiquitous in all recipient populations, suggesting a possible adaptive advantage. Introgressed alleles dominate at the MTCH2 locus, associated with obesity/fat tissue in humans, and the DSP locus, essential for the proper development of epidermal skin in amphibians. Furthermore, we found loci where local alleles were retained in the introgressed populations, suggesting their relevance for local adaptation. Finally, comparisons of genetic diversity between introgressed and nonintrogressed northern German populations revealed an increase in genetic diversity in all German individuals belonging to introgressed populations, supporting the idea of a beneficial transfer of genetic variation from Austria into North Germany.},
  language  = {en}
}
@article{CodecoWeisAndersen2022,
  author    = {Code{\c{c}}o, Marta S. and Weis, Philipp and Andersen, Christine},
  title     = {Numerical modeling of structurally controlled ore formation in magmatic-hydrothermal systems},
  series = {Geochemistry, geophysics, geosystems : G 3 ; an electronic journal of the earth sciences},
  volume    = {23},
  journal   = {Geochemistry, geophysics, geosystems : G 3 ; an electronic journal of the earth sciences},
  number    = {8},
  publisher = {American Geophysical Union},
  address   = {Washington, DC},
  issn      = {1525-2027},
  doi       = {10.1029/2021GC010302},
  pages     = {20},
  year      = {2022},
  abstract  = {Faults and fractures can be permeable pathways for focused fluid flow in structurally controlled ore-forming hydrothermal systems. However, quantifying their role in fluid flow on the scale of several kilometers with numerical models typically requires high-resolution meshes. This study introduces a modified numerical representation of m-scale fault zones using lower-dimensional elements (here, one-dimensional [1D] elements in a 2D domain) to resolve structurally controlled fluid flow with coarser mesh resolutions and apply the method to magmatic-hydrothermal ore-forming systems. We modeled horizontal and vertical structure-controlled magmatic-hydrothermal deposits to understand the role of permeability and structure connectivity on ore deposition. The simulation results of vertically extended porphyry copper systems show that ore deposition can occur along permeable vertical structures where ascending, overpressured magmatic fluids are cooled by downflowing ambient fluids. Structure permeability and fault location control the distribution of ore grades. In highly permeable structures, the mineralization can span up to 3 km vertically, resulting in heat-pipe mechanisms that promote the ascent of a magmatic vapor phase to an overlying structurally controlled epithermal system. Simulations for the formation of subhorizontal vein-type deposits suggest that the major control on fluid flow and metal deposition along horizontal structures is the absence of vertical structures above the injection location but their presence at greater distances. Using a dynamic permeability model mimicking crack-seal mechanisms within the structures leads to a pulsating behavior of fracture-controlled hydrothermal systems and prevents the inflow of ambient fluids under overpressured conditions.},
  language  = {en}
}
@article{LipusJiaBartholomaeusetal.2022,
  author    = {Lipus, Daniel and Jia, Zeyu and Bartholom{\"a}us, Alexander and Burckhardt, Oliver and Sondermann, Megan and Wagner, Dirk and Kallmeyer, Jens},
  title     = {Circular metagenome-assembled genome of Methanobacterium sp. strain ERen5, a putative methanogenic, H2-utilizing terrestrial subsurface archaeon},
  series = {Microbiology Resource Announcements},
  volume    = {11},
  journal   = {Microbiology Resource Announcements},
  number    = {10},
  publisher = {American Society for Microbiology},
  address   = {Washington},
  issn      = {2576-098X},
  doi       = {10.1128/mra.00676-22},
  pages     = {2},
  year      = {2022},
  abstract  = {A circular, single-contig Methanobacterium sp. metagenome-assembled genome (MAG) was recovered from high-CO2 enrichments inoculated with drill core material from the tectonic Eger Rift terrestrial subsurface. Annotation of the recovered MAG highlighted putative methanogenesis genes, providing valuable information on archaeal activity in the deep biosphere.},
  language  = {en}
}
@article{BartholomaeusMitzscherlingLipusetal.2022,
  author    = {Bartholom{\"a}us, Alexander and Mitzscherling, Julia and Lipus, Daniel and MacLean, Joana and Wagner, Dirk},
  title     = {Draft genome sequence of Paenalcaligenes niemegkensis NGK35T, isolated from plastic-polluted soil of an abandoned landfill},
  series = {Microbiology Resource Announcements},
  volume    = {11},
  journal   = {Microbiology Resource Announcements},
  number    = {10},
  publisher = {American Society for Microbiology},
  address   = {Washington},
  issn      = {2576-098X},
  doi       = {10.1128/mra.00671-22},
  pages     = {2},
  year      = {2022},
  abstract  = {The Gram-negative bacterium Paenalcaligenes niemegkensis NGK35(T) was isolated from plastic debris in an abandoned landfill. It has the ability to grow on polyethylene and hexadecane as the sole carbon sources. Here, we report the corresponding draft genome, which contains 3.66 Mbp and is characterized by a G+C content of 52.1\%.},
  language  = {en}
}
@article{TaboriSchneiderLuethetal.2022,
  author    = {Tabori, Harold and Schneider, Jochen and L{\"u}th, Stefan and Zagoya, Carlos and Barucha, Anton and Lehmann, Thomas and Kauf, Eberhard and Barth, Astrid and Mainz, Jochen G.},
  title     = {Elevated levels of toxic bile acids in serum of cystic fibrosis patients with CFTR mutations causing pancreatic insufficiency},
  series = {International journal of molecular sciences},
  volume    = {23},
  journal   = {International journal of molecular sciences},
  number    = {20},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {1422-0067},
  doi       = {10.3390/ijms232012436},
  pages     = {16},
  year      = {2022},
  abstract  = {Hepatobiliary involvement is a hallmark in cystic fibrosis (CF), as the causative CF Transmembrane Conductance Regulator (CFTR) defect is expressed in the biliary tree. However, bile acid (BA) compositions in regard to pancreatic insufficiency, which is present at an early stage in about 85\% of CF patients, have not been satisfactorily understood. We assess the pattern of serum BAs in people with CF (pwCF) without CFTR modulator therapy in regard to pancreatic insufficiency and the CFTR genotype. In 47 pwCF, 10 free and 12 taurine- and glycine-conjugated BAs in serum were prospectively assessed. Findings were related to genotype, pancreatic insufficiency prevalence (PIP)-score, and hepatic involvement indicated by serum liver enzymes, as well as clinical and ultrasound criteria for CF-related liver disease. Serum concentrations of total primary BAs and free cholic acid (CA) were significantly higher in pwCF with higher PIP-scores (p = 0.025, p = 0.009, respectively). Higher total BAs were seen in pwCF with PIP-scores >= 0.88 (p = 0.033) and with pancreatic insufficiency (p = 0.034). Free CA was higher in patients with CF-related liver involvement without cirrhosis, compared to pwCF without liver disease (2.3-fold, p = 0.036). pwCF with severe CFTR genotypes, as assessed by the PIP-score, reveals more toxic BA compositions in serum. Subsequent studies assessing changes in BA homeostasis during new highly effective CFTR-modulating therapies are of high interest.},
  language  = {en}
}
@article{DattaMorassiSassoKiwitetal.2022,
  author    = {Datta, Suparno and Morassi Sasso, Ariane and Kiwit, Nina and Bose, Subhronil and Nadkarni, Girish and Miotto, Riccardo and B{\"o}ttinger, Erwin P.},
  title     = {Predicting hypertension onset from longitudinal electronic health records with deep learning},
  series = {JAMIA Open},
  volume    = {5},
  journal   = {JAMIA Open},
  number    = {4},
  publisher = {Oxford Univ. Press},
  address   = {Oxford},
  issn      = {2574-2531},
  doi       = {10.1093/jamiaopen/ooac097},
  pages     = {10},
  year      = {2022},
  abstract  = {Objective: Hypertension has long been recognized as one of the most important predisposing factors for cardiovascular diseases and mortality. In recent years, machine learning methods have shown potential in diagnostic and predictive approaches in chronic diseases. Electronic health records (EHRs) have emerged as a reliable source of longitudinal data. The aim of this study is to predict the onset of hypertension using modern deep learning (DL) architectures, specifically long short-term memory (LSTM) networks, and longitudinal EHRs. Materials and Methods: We compare this approach to the best performing models reported from previous works, particularly XGboost, applied to aggregated features. Our work is based on data from 233 895 adult patients from a large health system in the United States. We divided our population into 2 distinct longitudinal datasets based on the diagnosis date. To ensure generalization to unseen data, we trained our models on the first dataset (dataset A "train and validation") using cross-validation, and then applied the models to a second dataset (dataset B "test") to assess their performance. We also experimented with 2 different time-windows before the onset of hypertension and evaluated the impact on model performance. Results: With the LSTM network, we were able to achieve an area under the receiver operating characteristic curve value of 0.98 in the "train and validation" dataset A and 0.94 in the "test" dataset B for a prediction time window of 1 year. Lipid disorders, type 2 diabetes, and renal disorders are found to be associated with incident hypertension. Conclusion: These findings show that DL models based on temporal EHR data can improve the identification of patients at high risk of hypertension and corresponding driving factors. In the long term, this work may support identifying individuals who are at high risk for developing hypertension and facilitate earlier intervention to prevent the future development of hypertension.},
  language  = {en}
}
@article{OwoyeleTrujillodeMeloetal.2022,
  author    = {Owoyele, Babajide and Trujillo, James and de Melo, Gerard and Pouw, Wim},
  title     = {Masked-Piper: masking personal identities in visual recordings while preserving multimodal information},
  series = {SoftwareX},
  volume    = {20},
  journal   = {SoftwareX},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {2352-7110},
  doi       = {10.1016/j.softx.2022.101236},
  pages     = {4},
  year      = {2022},
  abstract  = {In this increasingly data-rich world, visual recordings of human behavior are often unable to be shared due to concerns about privacy. Consequently, data sharing in fields such as behavioral science, multimodal communication, and human movement research is often limited. In addition, in legal and other non-scientific contexts, privacy-related concerns may preclude the sharing of video recordings and thus remove the rich multimodal context that humans recruit to communicate. Minimizing the risk of identity exposure while preserving critical behavioral information would maximize utility of public resources (e.g., research grants) and time invested in audio-visual research. Here we present an open-source computer vision tool that masks the identities of humans while maintaining rich information about communicative body movements. Furthermore, this masking tool can be easily applied to many videos, leveraging computational tools to augment the reproducibility and accessibility of behavioral research. The tool is designed for researchers and practitioners engaged in kinematic and affective research. Application areas include teaching/education, communication and human movement research, CCTV, and legal contexts.},
  language  = {en}
}
@article{GiraudierVenturaBortWendtetal.2022,
  author    = {Giraudier, Manon and Ventura-Bort, Carlos and Wendt, Julia and Lischke, Alexander and Weymar, Mathias},
  title     = {Memory advantage for untrustworthy faces},
  series = {PLoS one},
  volume    = {17},
  journal   = {PLoS one},
  number    = {2},
  publisher = {PLoS},
  address   = {San Fransisco},
  issn      = {1932-6203},
  doi       = {10.1371/journal.pone.0264034},
  pages     = {11},
  year      = {2022},
  abstract  = {The Covid-19 pandemic imposed new constraints on empirical research and forced researchers to transfer from traditional laboratory research to the online environment. This study tested the validity of a web-based episodic memory paradigm by comparing participants' memory performance for trustworthy and untrustworthy facial stimuli in a supervised laboratory setting and an unsupervised web setting. Consistent with previous results, we observed enhanced episodic memory for untrustworthy compared to trustworthy faces. Most importantly, this memory bias was comparable in the online and the laboratory experiment, suggesting that web-based procedures are a promising tool for memory research.},
  language  = {en}
}
@article{GiraudierVenturaBortWendtetal.2022,
  author    = {Giraudier, Manon and Ventura-Bort, Carlos and Wendt, Julia and Lischke, Alexander and Weymar, Mathias},
  title     = {Memory advantage for untrustworthy faces: Replication across lab- and web-based studies},
  series = {PLoS ONE},
  volume    = {17},
  journal   = {PLoS ONE},
  edition   = {2},
  publisher = {PLoS ONE},
  address   = {San Francisco, California, US},
  issn      = {1932-6203},
  doi       = {10.1371/journal.pone.0264034},
  pages     = {1 -- 11},
  year      = {2022},
  abstract  = {The Covid-19 pandemic imposed new constraints on empirical research and forced researchers to transfer from traditional laboratory research to the online environment. This study tested the validity of a web-based episodic memory paradigm by comparing participants' memory performance for trustworthy and untrustworthy facial stimuli in a supervised laboratory setting and an unsupervised web setting. Consistent with previous results, we observed enhanced episodic memory for untrustworthy compared to trustworthy faces. Most importantly, this memory bias was comparable in the online and the laboratory experiment, suggesting that web-based procedures are a promising tool for memory research.},
  language  = {en}
}
@article{RikaniFrielerSchewe2022,
  author    = {Rikani, Albano and Frieler, Katja and Schewe, Jacob},
  title     = {Climate change and international migration},
  series = {PLoS one},
  volume    = {17},
  journal   = {PLoS one},
  number    = {11},
  publisher = {PLoS},
  address   = {San Fransisco},
  issn      = {1932-6203},
  doi       = {10.1371/journal.pone.0276764},
  pages     = {25},
  year      = {2022},
  abstract  = {International migration patterns, at the global level, can to a large extent be explained through economic factors in origin and destination countries. On the other hand, it has been shown that global climate change is likely to affect economic development over the coming decades. Here, we demonstrate how these future climate impacts on national income levels could alter the global migration landscape. Using an empirically calibrated global migration model, we investigate two separate mechanisms. The first is through destination-country income, which has been shown consistently to have a positive effect on immigration. As countries' income levels relative to each other are projected to change in the future both due to different rates of economic growth and due to different levels of climate change impacts, the relative distribution of immigration across destination countries also changes as a result, all else being equal. Second, emigration rates have been found to have a complex, inverted U-shaped dependence on origin-country income. Given the available migration flow data, it is unclear whether this dependence-found in spatio-temporal panel data-also pertains to changes in a given migration flow over time. If it does, then climate change will additionally affect migration patterns through origin countries' emigration rates, as the relative and absolute positions of countries on the migration "hump" change. We illustrate these different possibilities, and the corresponding effects of 3 degrees C global warming (above pre-industrial) on global migration patterns, using climate model projections and two different methods for estimating climate change effects on macroeconomic development.},
  language  = {en}
}
@article{GiraudierVenturaBortBurgeretal.2022,
  author    = {Giraudier, Manon and Ventura-Bort, Carlos and Burger, Andreas M. and Claes, Nathalie and D'Agostini, Martina and Fischer, Rico and Franssen, Mathijs and Kaess, Michael and Koenig, Julian and Liepelt, Roman and Nieuwenhuis, Sander and Sommer, Aldo and Usichenko, Taras and Van Diest, Ilse and von Leupoldt, Andreas and Warren, Christopher Michael and Weymar, Mathias},
  title     = {Evidence for a modulating effect of transcutaneous auricular vagus nerve stimulation (taVNS) on salivary alpha-amylase as indirect noradrenergic marker: A pooled mega-analysis},
  series = {Brain Stimulation},
  volume    = {15},
  journal   = {Brain Stimulation},
  edition   = {6},
  publisher = {Elsevier},
  address   = {New York, NY, USA},
  issn      = {1876-4754},
  doi       = {10.1016/j.brs.2022.09.009},
  pages     = {1378 -- 1388},
  year      = {2022},
  abstract  = {Background Non-invasive transcutaneous auricular vagus nerve stimulation (taVNS) has received tremendous attention as a potential neuromodulator of cognitive and affective functions, which likely exerts its effects via activation of the locus coeruleus-noradrenaline (LC-NA) system. Reliable effects of taVNS on markers of LC-NA system activity, however, have not been demonstrated yet. Methods The aim of the present study was to overcome previous limitations by pooling raw data from a large sample of ten taVNS studies (371 healthy participants) that collected salivary alpha-amylase (sAA) as a potential marker of central NA release. Results While a meta-analytic approach using summary statistics did not yield any significant effects, linear mixed model analyses showed that afferent stimulation of the vagus nerve via taVNS increased sAA levels compared to sham stimulation (b = 0.16, SE = 0.05, p = 0.001). When considering potential confounders of sAA, we further replicated previous findings on the diurnal trajectory of sAA activity. Conclusion(s) Vagal activation via taVNS increases sAA release compared to sham stimulation, which likely substantiates the assumption that taVNS triggers NA release. Moreover, our results highlight the benefits of data pooling and data sharing in order to allow stronger conclusions in research.},
  language  = {en}
}
@article{GiraudierVenturaBortWeymar2020,
  author    = {Giraudier, Manon and Ventura-Bort, Carlos and Weymar, Mathias},
  title     = {Transcutaneous Vagus Nerve Stimulation (tVNS) Improves High-Confidence Recognition Memory but Not Emotional Word Processing},
  series = {Frontiers in Psychology},
  volume    = {11},
  journal   = {Frontiers in Psychology},
  publisher = {Frontiers Research Foundation},
  address   = {Lausanne},
  issn      = {1664-1078},
  doi       = {10.3389/fpsyg.2020.01276},
  pages     = {13},
  year      = {2020},
  abstract  = {Previous clinical research found that invasive vagus nerve stimulation (VNS) enhanced word recognition memory in epileptic patients, an effect assumed to be related to the activation of brainstem arousal systems. In this study, we applied non-invasive transcutaneous auricular VNS (tVNS) to replicate and extend the previous work. Using a single-blind, randomized, between-subject design, 60 healthy volunteers received active or sham stimulation during a lexical decision task, in which emotional and neutral stimuli were classified as words or non-words. In a subsequent recognition memory task (1 day after stimulation), participants' memory performance on these words and their subjective memory confidence were tested. Salivary alpha-amylase (sAA) levels, a putative indirect measure of central noradrenergic activation, were also measured before and after stimulation. During encoding, pleasant words were more accurately detected than neutral and unpleasant words. However, no tVNS effects were observed on task performance or on overall sAA level changes. tVNS also did not modulate overall recognition memory, which was particularly enhanced for pleasant emotional words. However, when hit rates were split based on confidence ratings reflecting familiarity- and recollection-based memory, higher recollection-based memory performance (irrespective of emotional category) was observed during active stimulation than during sham stimulation. To summarize, we replicated prior findings of enhanced processing and memory for emotional (pleasant) words. Whereas tVNS showed no effects on word processing, subtle effects on recollection-based memory performance emerged, which may indicate that tVNS facilitates hippocampus-mediated consolidation processes.},
  language  = {en}
}
@article{VenturaBortWendtWeymar2021,
  author    = {Ventura-Bort, Carlos and Wendt, Julia and Weymar, Mathias},
  title     = {The Role of Interoceptive Sensibility and Emotional Conceptualization for the Experience of Emotions},
  series = {Frontiers in psychology},
  volume    = {12},
  journal   = {Frontiers in psychology},
  publisher = {Frontiers Research Foundation},
  address   = {Lausanne, Schweiz},
  issn      = {1664-1078},
  doi       = {10.3389/fpsyg.2021.712418},
  pages     = {1 -- 15},
  year      = {2021},
  abstract  = {The theory of constructed emotions suggests that different psychological components, including core affect (mental and neural representations of bodily changes), and conceptualization (meaning-making based on prior experiences and semantic knowledge), are involved in the formation of emotions. However, little is known about their role in experiencing emotions. In the current study, we investigated how individual differences in interoceptive sensibility and emotional conceptualization (as potential correlates of these components) interact to moderate three important aspects of emotional experiences: emotional intensity (strength of emotion felt), arousal (degree of activation), and granularity (ability to differentiate emotions with precision). To this end, participants completed a series of questionnaires assessing interoceptive sensibility and emotional conceptualization and underwent two emotion experience tasks, which included standardized material (emotion differentiation task; ED task) and self-experienced episodes (day reconstruction method; DRM). Correlational analysis showed that individual differences in interoceptive sensibility and emotional conceptualization were related to each other. Principal Component Analysis (PCA) revealed two independent factors that were referred to as sensibility and monitoring. The Sensibility factor, interpreted as beliefs about the accuracy of an individual in detecting internal physiological and emotional states, predicted higher granularity for negative words. The Monitoring factor, interpreted as the tendency to focus on the internal states of an individual, was negatively related to emotional granularity and intensity. Additionally, Sensibility scores were more strongly associated with greater well-being and adaptability measures than Monitoring scores. Our results indicate that independent processes underlying individual differences in interoceptive sensibility and emotional conceptualization contribute to emotion experiencing.},
  language  = {en}
}
@article{WachsVazsonyiWrightetal.2020,
  author    = {Wachs, Sebastian and Vazsonyi, Alexander T. and Wright, Michelle F. and Ksinan Jiskrova, Gabriela},
  title     = {Cross-National Associations Among Cyberbullying Victimization, Self-Esteem, and Internet Addiction},
  series = {Frontiers in Psychology},
  volume    = {11},
  journal   = {Frontiers in Psychology},
  publisher = {Frontiers Research Foundation},
  address   = {Lausanne},
  issn      = {1664-1078},
  doi       = {10.3389/fpsyg.2020.01368},
  pages     = {10},
  year      = {2020},
  abstract  = {The relationship among cyberbullying victimization, lower self-esteem, and internet addiction has been well-established. Yet, little research exists that explains the nature of these associations, and no previous work has considered the inability to identify or describe one's emotions, namely, alexithymia, as a potential mediator of these links. The present study sought to investigate the indirect effects of cyberbullying victimization on self-esteem and internet addiction, mediated by alexithymia. The sample consisted of 1,442 participants between 12 and 17 years (Mage = 14.17, SD = 1.38, 51.5\% male) from Germany, the Netherlands, and the United States. Results showed a direct relationship between cyberbullying victimization and self-esteem and an indirect association mediated by alexithymia in the Dutch sample. However, in the German and U.S. samples, only an indirect relationship via alexithymia, but not a direct effect of cyberbullying victimization on self-esteem, was found. Consistent across the three country samples, cyberbullying victimization and internet addiction were directly and also indirectly associated via alexithymia. In sum, findings indicate that alexithymia might help better understand which detrimental effects cyberbullying victimization has on adolescent psychological health. Thus, cyberbullying prevention programs should consider implementing elements that educate adolescents on the ability to identify and describe their own emotions.},
  language  = {en}
}
@article{SeboldChenOenaletal.2022,
  author    = {Sebold, Miriam and Chen, Hao and {\"O}nal, Aleyna and Kuitunen-Paul, S{\"o}ren and Mojtahedzadeh, Negin and Garbusow, Maria and Nebe, Stephan and Wittchen, Hans-Ulrich and Huys, Quentin J. M. and Schlagenhauf, Florian and Rapp, Michael A. and Smolka, Michael N. and Heinz, Andreas},
  title     = {Stronger prejudices are associated with decreased model-based control},
  series = {Frontiers in psychology},
  volume    = {12},
  journal   = {Frontiers in psychology},
  publisher = {Frontiers Research Foundation},
  address   = {Lausanne},
  issn      = {1664-1078},
  doi       = {10.3389/fpsyg.2021.767022},
  pages     = {10},
  year      = {2022},
  abstract  = {Background: Prejudices against minorities can be understood as habitually negative evaluations that are kept in spite of evidence to the contrary. Therefore, individuals with strong prejudices might be dominated by habitual or "automatic" reactions at the expense of more controlled reactions. Computational theories suggest individual differences in the balance between habitual/model-free and deliberative/model-based decision-making. Methods: 127 subjects performed the two Step task and completed the blatant and subtle prejudice scale. Results: By using analyses of choices and reaction times in combination with computational modeling, subjects with stronger blatant prejudices showed a shift away from model-based control. There was no association between these decision-making processes and subtle prejudices. Conclusion: These results support the idea that blatant prejudices toward minorities are related to a relative dominance of habitual decision-making. This finding has important implications for developing interventions that target to change prejudices across societies.},
  language  = {en}
}
@article{WrightWachsYanagidaetal.2022,
  author    = {Wright, Michelle F. and Wachs, Sebastian and Yanagida, Takuya and Sevcikova, Anna and Dedkova, Lenka and Bayraktar, Fatih and Aoyama, Ikuko and Kamble, Shanmukh and Mach{\´a}čkov{\´a}, Hana and Li, Zheng and Soudi, Shruti and Lei, Li and Shu, Chang},
  title     = {Coping with Public and Private Face-to-Face and Cyber Victimization among Adolescents in Six Countries},
  series = {International journal of environmental research and public health},
  volume    = {19},
  journal   = {International journal of environmental research and public health},
  number    = {21},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {1661-7827},
  doi       = {10.3390/ijerph192114405},
  pages     = {11},
  year      = {2022},
  abstract  = {This study investigated the role of medium (face-to-face, cyber) and publicity (public, private) in adolescents' perceptions of severity and coping strategies (i.e., avoidant, ignoring, helplessness, social support seeking, retaliation) for victimization, while accounting for gender and cultural values. There were 3432 adolescents (ages 11-15, 49\% girls) in this study; they were from China, Cyprus, the Czech Republic, India, Japan, and the United States. Adolescents completed questionnaires on individualism and collectivism, and ratings of coping strategies and severity for public face-to-face victimization, private face-to-face victimization, public cyber victimization, and private cyber victimization. Findings revealed similarities in adolescents' coping strategies based on perceptions of severity, publicity, and medium for some coping strategies (i.e., social support seeking, retaliation) but differential associations for other coping strategies (i.e., avoidance, helplessness, ignoring). The results of this study are important for prevention and intervention efforts because they underscore the importance of teaching effective coping strategies to adolescents, and to consider how perceptions of severity, publicity, and medium might influence the implementation of these coping strategies.},
  language  = {en}
}
@article{HongKimThornbergetal.2022,
  author    = {Hong, Jun Sung and Kim, Dong Ha and Thornberg, Robert and Wachs, Sebastian and Wright, Michelle F.},
  title     = {Racial discrimination to bullying behavior among White and Black adolescents in the USA: from parents' perspectives},
  series = {International journal of environmental research and public health},
  volume    = {19},
  journal   = {International journal of environmental research and public health},
  number    = {12},
  publisher = {MDPI AG},
  address   = {Basel},
  issn      = {1660-4601},
  doi       = {10.3390/ijerph19127084},
  pages     = {11},
  year      = {2022},
  abstract  = {The present study proposes and tests pathways by which racial discrimination might be positively related to bullying victimization among Black and White adolescents. Data were derived from the 2016 National Survey of Children's Health, a national survey that provides data on children's physical and mental health and their families. Data were collected from households with one or more children between June 2016 to February 2017. A letter was sent to randomly selected households, who were invited to participate in the survey. The caregivers consisted of 66.9\% females and 33.1\% males for the White sample, whose mean age was 47.51 (SD = 7.26), and 76.8\% females and 23.2\% males for the Black sample, whose mean age was 47.61 (SD = 9.71). In terms of the adolescents, 49.0\% were females among the White sample, whose mean age was 14.73 (SD = 1.69). For Black adolescents, 47.9\% were females and the mean age was 14.67(SD = 1.66). Measures for the study included bullying perpetration, racial discrimination, academic disengagement, and socio-demographic variables of the parent and child. Analyses included descriptive statistics, bivariate correlations, and structural path analyses. For adolescents in both racial groups, racial discrimination appears to be positively associated with depression, which was positively associated with bullying perpetration. For White adolescents, racial discrimination was positively associated with academic disengagement, which was also positively associated with bullying perpetration. For Black adolescents, although racial discrimination was not significantly associated with academic disengagement, academic disengagement was positively associated with bullying perpetration.},
  language  = {en}
}
@article{MazzoneWachsFoodyetal.2022,
  author    = {Mazzone, Angela and Wachs, Sebastian and Foody, Mairead and Blaya, Catherine},
  title     = {Editorial: A connected or isolated generation?},
  series = {Frontiers in education},
  volume    = {7},
  journal   = {Frontiers in education},
  publisher = {Frontiers Media},
  address   = {Lausanne},
  issn      = {2504-284X},
  doi       = {10.3389/feduc.2022.999028},
  pages     = {3},
  year      = {2022},
  language  = {en}
}
@article{WachsBilzFischeretal.2017,
  author    = {Wachs, Sebastian and Bilz, Ludwig and Fischer, Saskia M. and Wright, Michelle F.},
  title     = {Do emotional components of alexithymia mediate the interplay between cyberbullying victimization and perpetration?},
  series = {International Journal of Environmental Research and Public Health},
  volume    = {14},
  journal   = {International Journal of Environmental Research and Public Health},
  number    = {12},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {1660-4601},
  doi       = {10.3390/ijerph14121530},
  pages     = {11},
  year      = {2017},
  abstract  = {A substantial amount of research has revealed that cyberbully-victims have more emotional and behavioral problems than either cyberbullying victims or perpetrators. However, until now, little research has been conducted into the factors that contribute to the interplay between cyberbullying victimization and perpetration. The purpose of this study was to examine the relationship between cyberbullying victimization, perpetration, and two emotional components of alexithymia, namely difficulties in identifying and describing one's own feelings. Self-report questions were administered to 1549 adolescents between 12 and 18 years old (M = 14.51; SD = 1.68; 42.1\% (n = 652) male) from Germany and Thailand. Results showed that cyberbullying victimization and alexithymia are associated with cyberbullying perpetration. Moreover, alexithymia mediated the associations between cyberbullying victimization and adolescents' cyberbullying perpetration. Consequently, we suggest that the ability to describe and identify one's own feelings might be important for understanding the link between cyberbullying, victimization, and perpetration. The results may help develop prevention and intervention programs focused on reducing cyberbullying.},
  language  = {en}
}
@article{GamezGuadixMateosWachsetal.2022,
  author    = {G{\´a}mez-Guadix, Manuel and Mateos, Estibaliz and Wachs, Sebastian and Blanco, Marta},
  title     = {Self-harm on the internet among adolescents},
  series = {Psicothema},
  volume    = {34},
  journal   = {Psicothema},
  number    = {2},
  publisher = {Departamento de Psicolog{\´i}a de la Universidad de Oviedo, Colegio Oficial de Psic{\´o}logos del Principado de Asturias, Vicerrectorado de Investigaci{\´o}n de la Universidad de Oviedo},
  address   = {Oviedo},
  issn      = {0214-9915},
  doi       = {10.7334/psicothema2021.328},
  pages     = {233 -- 239},
  year      = {2022},
  abstract  = {Background: Using the internet to search for information or share images about self-harm is an emerging risk among young people. The aims of this study were (a) to analyze the prevalence of different types of self-harm on the internet and differences by sex and age, and (b) to examine the relationship of self-harm on the internet with intrapersonal factors (i.e., depression and anxiety) and interpersonal factors (i.e., family cohesion and social resources). Method: The sample consisted of 1,877 adolescents (946 girls) between 12 and 17 years old (Mage = 13.41, SD = 1.25) who completed self-report measures. Results: Approximately 11\% of the participants had been involved in some type of self-harm on the internet. The prevalence was significantly higher among girls than boys and among adolescents older than 15 years old. Depression and anxiety increased the risk of self-harm on the internet, whereas family cohesion decreased the probability of self-harm on the internet. Conclusions: Self-harm on the internet is a relatively widespread phenomenon among Spanish adolescents. Prevention programs should include emotional regulation, coping skills, and resilience to reduce in this behavior.},
  language  = {en}
}
@article{KasalBesirogluZorluetal.2021,
  author    = {Kasal, Meltem and Besiroglu, Lutfullah and Zorlu, Nabi and Dikmeer, Nur and Bilge, Aslihan and Durmaz, Ercan and Polat, Serap and Gelal, Fazil and Rapp, Michael A. and Heinz, Andreas and Sebold, Miriam},
  title     = {Fronto-striatal structures related with model-based control as an endophenotype for obsessive-compulsive disorder},
  series = {Scientific reports},
  volume    = {11},
  journal   = {Scientific reports},
  number    = {1},
  publisher = {Springer Nature},
  address   = {[London]},
  issn      = {2045-2322},
  doi       = {10.1038/s41598-021-91179-2},
  pages     = {10},
  year      = {2021},
  abstract  = {Recent theories suggest a shift from model-based goal-directed to model-free habitual decision-making in obsessive-compulsive disorder (OCD). However, it is yet unclear, whether this shift in the decision process is heritable. We investigated 32 patients with OCD, 27 unaffected siblings (SIBs) and 31 healthy controls (HCs) using the two-step task. We computed behavioral and reaction time analyses and fitted a computational model to assess the balance between model-based and model-free control. 80 subjects also underwent structural imaging. We observed a significant ordered effect for the shift towards model-free control in the direction OCD>SIB>HC in our computational parameter of interest. However less directed analyses revealed no shift towards model-free control in OCDs. Nonetheless, we found evidence for reduced model-based control in OCDs compared to HCs and SIBs via 2nd stage reaction time analyses. In this measure SIBs also showed higher levels of model-based control than HCs. Across all subjects these effects were associated with the surface area of the left medial/right dorsolateral prefrontal cortex. Moreover, correlations between bilateral putamen/right caudate volumes and these effects varied as a function of group: they were negative in SIBs and OCDs, but positive in HCs. Associations between fronto-striatal regions and model-based reaction time effects point to a potential endophenotype for OCD.},
  language  = {en}
}
@article{WrightWachsHuang2020,
  author    = {Wright, Michelle F. and Wachs, Sebastian and Huang, Zheng},
  title     = {Adolescents' Popularity-Motivated Aggression and Prosocial Behaviors: The Roles of Callous-Unemotional Traits and Social Status Insecurity},
  series = {Frontiers in Psychology},
  journal   = {Frontiers in Psychology},
  publisher = {Frontiers},
  address   = {Lausanne, Schweiz},
  issn      = {1664-1078},
  doi       = {10.3389/fpsyg.2021.606865},
  pages     = {1 -- 8},
  year      = {2020},
  abstract  = {As competition over peer status becomes intense during adolescence, some adolescents develop insecure feelings regarding their social standing among their peers (i.e., social status insecurity). These adolescents sometimes use aggression to defend or promote their status. The aim of this study was to examine the relationships among social status insecurity, callous-unemotional (CU) traits, and popularity-motivated aggression and prosocial behaviors among adolescents, while controlling for gender. Another purpose was to examine the potential moderating role of CU traits in these relationships. Participants were 1,047 (49.2\% girls; Mage = 12.44 years; age range from 11 to 14 years) in the 7th or 8th grades from a large Midwestern city. They completed questionnaires on social status insecurity, CU traits, and popularity-motivated relational aggression, physical aggression, cyberaggression, and prosocial behaviors. A structural regression model was conducted, with gender as a covariate. The model had adequate fit. Social status insecurity was associated positively with callousness, unemotional, and popularity-motivated aggression and related negatively to popularity-motivated prosocial behaviors. High social status insecurity was related to greater popularity-motivated aggression when adolescents had high callousness traits. The findings have implications for understanding the individual characteristics associated with social status insecurity.},
  language  = {en}
}
@article{WachsWrightSittichaietal.2019,
  author    = {Wachs, Sebastian and Wright, Michelle F. and Sittichai, Ruthaychonnee and Singh, Ritu and Biswal, Ramakrishna and Kim, Eun-mee and Yang, Soeun and G{\´a}mez-Guadix, Manuel and Almendros, Carmen and Flora, Katerina and Daskalou, Vassiliki and Maziridou, Evdoxia},
  title     = {Associations between witnessing and perpetrating online hate in eight countries},
  series = {International Journal of Environmental Research and Public Health},
  volume    = {16},
  journal   = {International Journal of Environmental Research and Public Health},
  number    = {20},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {1660-4601},
  doi       = {10.3390/ijerph16203992},
  pages     = {13},
  year      = {2019},
  abstract  = {Online hate is a topic that has received considerable interest lately, as online hate represents a risk to self-determination and peaceful coexistence in societies around the globe. However, not much is known about the explanations for adolescents posting or forwarding hateful online material or how adolescents cope with this newly emerging online risk. Thus, we sought to better understand the relationship between a bystander to and perpetrator of online hate, and the moderating effects of problem-focused coping strategies (e.g., assertive, technical coping) within this relationship. Self-report questionnaires on witnessing and committing online hate and assertive and technical coping were completed by 6829 adolescents between 12 and 18 years of age from eight countries. The results showed that increases in witnessing online hate were positively related to being a perpetrator of online hate. Assertive and technical coping strategies were negatively related with perpetrating online hate. Bystanders of online hate reported fewer instances of perpetrating online hate when they reported higher levels of assertive and technical coping strategies, and more frequent instances of perpetrating online hate when they reported lower levels of assertive and technical coping strategies. In conclusion, our findings suggest that, if effective, prevention and intervention programs that target online hate should consider educating young people about problem-focused coping strategies, self-assertiveness, and media skills. Implications for future research are discussed.},
  language  = {en}
}
@article{VillalbaKasadaZoccaratoetal.2022,
  author    = {Villalba, Luis Alberto and Kasada, Minoru and Zoccarato, Luca and Wollrab, Sabine and Grossart, Hans Peter},
  title     = {Differing escape responses of the marine bacterium Marinobacter adhaerens in the presence of planktonic vs. surface-associated protist grazers},
  series = {International journal of molecular sciences},
  volume    = {23},
  journal   = {International journal of molecular sciences},
  number    = {17},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {1661-6596},
  doi       = {10.3390/ijms231710082},
  pages     = {13},
  year      = {2022},
  abstract  = {Protist grazing pressure plays a major role in controlling aquatic bacterial populations, affecting energy flow through the microbial loop and biogeochemical cycles. Predator-escape mechanisms might play a crucial role in energy flow through the microbial loop, but are yet understudied. For example, some bacteria can use planktonic as well as surface-associated habitats, providing a potential escape mechanism to habitat-specific grazers. We investigated the escape response of the marine bacterium Marinobacter adhaerens in the presence of either planktonic (nanoflagellate: Cafeteria roenbergensis) or surface-associated (amoeba: Vannella anglica) protist predators, following population dynamics over time. In the presence of V. anglica, M. adhaerens cell density increased in the water, but decreased on solid surfaces, indicating an escape response towards the planktonic habitat. In contrast, the planktonic predator C. roenbergensis induced bacterial escape to the surface habitat. While C. roenbergensis cell numbers dropped substantially after a sharp initial increase, V. anglica exhibited a slow, but constant growth throughout the entire experiment. In the presence of C. roenbergensis, M. adhaerens rapidly formed cell clumps in the water habitat, which likely prevented consumption of the planktonic M. adhaerens by the flagellate, resulting in a strong decline in the predator population. Our results indicate an active escape of M. adhaerens via phenotypic plasticity (i.e., behavioral and morphological changes) against predator ingestion. This study highlights the potentially important role of behavioral escape mechanisms for community composition and energy flow in pelagic environments, especially with globally rising particle loads in aquatic systems through human activities and extreme weather events.},
  language  = {en}
}
@article{SamprognaMohorThiekenKorup2021,
  author    = {Samprogna Mohor, Guilherme and Thieken, Annegret and Korup, Oliver},
  title     = {Residential flood loss estimated from Bayesian multilevel models},
  series = {Natural Hazards and Earth System Sciences},
  volume    = {21},
  journal   = {Natural Hazards and Earth System Sciences},
  publisher = {European Geophysical Society},
  address   = {Katlenburg-Lindau},
  issn      = {2195-9269},
  doi       = {10.5194/nhess-21-1599-2021},
  pages     = {1599 -- 1614},
  year      = {2021},
  abstract  = {Models for the predictions of monetary losses from floods mainly blend data deemed to represent a single flood type and region. Moreover, these approaches largely ignore indicators of preparedness and how predictors may vary between regions and events, challenging the transferability of flood loss models. We use a flood loss database of 1812 German flood-affected households to explore how Bayesian multilevel models can estimate normalised flood damage stratified by event, region, or flood process type. Multilevel models acknowledge natural groups in the data and allow each group to learn from others. We obtain posterior estimates that differ between flood types, with credibly varying influences of water depth, contamination, duration, implementation of property-level precautionary measures, insurance, and previous flood experience; these influences overlap across most events or regions, however. We infer that the underlying damaging processes of distinct flood types deserve further attention. Each reported flood loss and affected region involved mixed flood types, likely explaining the uncertainty in the coefficients. Our results emphasise the need to consider flood types as an important step towards applying flood loss models elsewhere. We argue that failing to do so may unduly generalise the model and systematically bias loss estimations from empirical data.},
  language  = {en}
}
@article{vonSpechtOeztuerkVehetal.2019,
  author    = {von Specht, Sebastian and {\"O}zt{\"u}rk, Ugur and Veh, Georg and Cotton, Fabrice and Korup, Oliver},
  title     = {Effects of finite source rupture on landslide triggering},
  series = {Solid earth},
  volume    = {10},
  journal   = {Solid earth},
  number    = {2},
  publisher = {Copernicus},
  address   = {G{\"o}ttingen},
  issn      = {1869-9510},
  doi       = {10.5194/se-10-463-2019},
  pages     = {463 -- 486},
  year      = {2019},
  abstract  = {The propagation of a seismic rupture on a fault introduces spatial variations in the seismic wave field surrounding the fault. This directivity effect results in larger shaking amplitudes in the rupture propagation direction. Its seismic radiation pattern also causes amplitude variations between the strike-normal and strike-parallel components of horizontal ground motion. We investigated the landslide response to these effects during the 2016 Kumamoto earthquake (M-w 7.1) in central Kyushu (Japan). Although the distribution of some 1500 earthquake-triggered landslides as a function of rupture distance is consistent with the observed Arias intensity, the landslides were more concentrated to the northeast of the southwest-northeast striking rupture. We examined several landslide susceptibility factors: hillslope inclination, the median amplification factor (MAF) of ground shaking, lithology, land cover, and topographic wetness. None of these factors sufficiently explains the landslide distribution or orientation (aspect), although the landslide head scarps have an elevated hillslope inclination and MAF. We propose a new physics-based ground-motion model (GMM) that accounts for the seismic rupture effects, and we demonstrate that the low-frequency seismic radiation pattern is consistent with the overall landslide distribution. Its spatial pattern is influenced by the rupture directivity effect, whereas landslide aspect is influenced by amplitude variations between the fault-normal and fault-parallel motion at frequencies < 2 Hz. This azimuth dependence implies that comparable landslide concentrations can occur at different distances from the rupture. This quantitative link between the prevalent landslide aspect and the low-frequency seismic radiation pattern can improve coseismic landslide hazard assessment.},
  language  = {en}
}
@article{WangCherstvyMetzleretal.2022,
  author    = {Wang, Wei and Cherstvy, Andrey G. and Metzler, Ralf and Sokolov, Igor M.},
  title     = {Restoring ergodicity of stochastically reset anomalous-diffusion processes},
  series = {Physical Review Research},
  volume    = {4},
  journal   = {Physical Review Research},
  edition   = {1},
  publisher = {American Physical Society},
  address   = {College Park, Maryland, United States},
  issn      = {2643-1564},
  doi       = {10.1103/PhysRevResearch.4.013161},
  pages     = {013161-1 -- 013161-13},
  year      = {2022},
  abstract  = {How do different reset protocols affect ergodicity of a diffusion process in single-particle-tracking experiments? We here address the problem of resetting of an arbitrary stochastic anomalous-diffusion process (ADP) from the general mathematical points of view and assess ergodicity of such reset ADPs for an arbitrary resetting protocol. The process of stochastic resetting describes the events of the instantaneous restart of a particle's motion via randomly distributed returns to a preset initial position (or a set of those). The waiting times of such resetting events obey the Poissonian, Gamma, or more generic distributions with specified conditions regarding the existence of moments. Within these general approaches, we derive general analytical results and support them by computer simulations for the behavior of the reset mean-squared displacement (MSD), the new reset increment-MSD (iMSD), and the mean reset time-averaged MSD (TAMSD). For parental nonreset ADPs with the MSD(t)∝ tμ we find a generic behavior and a switch of the short-time growth of the reset iMSD and mean reset TAMSDs from ∝ _μ for subdiffusive to ∝ _1 for superdiffusive reset ADPs. The critical condition for a reset ADP that recovers its ergodicity is found to be more general than that for the nonequilibrium stationary state, where obviously the iMSD and the mean TAMSD are equal. The consideration of the new statistical quantifier, the iMSD—as compared to the standard MSD—restores the ergodicity of an arbitrary reset ADP in all situations when the μth moment of the waiting-time distribution of resetting events is finite. Potential applications of these new resetting results are, inter alia, in the area of biophysical and soft-matter systems.},
  language  = {en}
}
@article{KluthStadionGottmannetal.2019,
  author    = {Kluth, Oliver and Stadion, Mandy and Gottmann, Pascal and Aga-Barfknecht, Heja and J{\"a}hnert, Markus and Scherneck, Stephan and Vogel, Heike and Krus, Ulrika and Seelig, Anett and Ling, Charlotte and Gerdes, Jantje and Sch{\"u}rmann, Annette},
  title     = {Decreased expression of cilia genes in pancreatic islets as a risk factor for type 2 diabetes in mice and humans},
  series = {Cell reports},
  volume    = {26},
  journal   = {Cell reports},
  number    = {11},
  publisher = {Cell Press},
  address   = {Maryland Heights},
  issn      = {2211-1247},
  doi       = {10.1016/j.celrep.2019.02.056},
  pages     = {3027 -- 3036},
  year      = {2019},
  abstract  = {An insufficient adaptive beta-cell compensation is a hallmark of type 2 diabetes (T2D). Primary cilia function as versatile sensory antennae regulating various cellular processes, but their role on compensatory beta-cell replication has not been examined. Here, we identify a significant enrichment of downregulated, cilia-annotated genes in pancreatic islets of diabetes-prone NZO mice as compared with diabetes-resistant B6-ob/ob mice. Among 327 differentially expressed mouse cilia genes, 81 human orthologs are also affected in islets of diabetic donors. Islets of nondiabetic mice and humans show a substantial overlap of upregulated cilia genes that are linked to cell-cycle progression. The shRNA-mediated suppression of KIF3A, essential for ciliogenesis, impairs division of MINE beta cells as well as in dispersed primary mouse and human islet cells, as shown by decreased BrdU incorporation. These findings demonstrate the substantial role of cilia-gene regulation on islet function and T2D risk.},
  language  = {en}
}
@article{StieglerPahlGuillenetal.2023,
  author    = {Stiegler, Jonas and Pahl, Janice and Guillen, Rafael Arce and Ullmann, Wiebke and Blaum, Niels},
  title     = {The heat is on},
  series = {Frontiers in Ecology and Evolution},
  volume    = {11},
  journal   = {Frontiers in Ecology and Evolution},
  publisher = {Frontiers Media},
  address   = {Lausanne},
  issn      = {2296-701X},
  doi       = {10.3389/fevo.2023.1193861},
  pages     = {10},
  year      = {2023},
  abstract  = {Climate conditions severely impact the activity and, consequently, the fitness of wildlife species across the globe. Wildlife can respond to new climatic conditions, but the pace of human-induced change limits opportunities for adaptation or migration. Thus, how these changes affect behavior, movement patterns, and activity levels remains unclear. In this study, we investigate how extreme weather conditions affect the activity of European hares (Lepus europaeus) during their peak reproduction period. When hares must additionally invest energy in mating, prevailing against competitors, or lactating, we investigated their sensitivities to rising temperatures, wind speed, and humidity. To quantify their activity, we used the overall dynamic body acceleration (ODBA) calculated from tri-axial acceleration measurements of 33 GPS-collared hares. Our analysis revealed that temperature, humidity, and wind speed are important in explaining changes in activity, with a strong response for high temperatures above 25 \& DEG;C and the highest change in activity during temperature extremes of over 35 \& DEG;C during their inactive period. Further, we found a non-linear relationship between temperature and activity and an interaction of activity changes between day and night. Activity increased at higher temperatures during the inactive period (day) and decreased during the active period (night). This decrease was strongest during hot tropical nights. At a stage of life when mammals such as hares must substantially invest in reproduction, the sensitivity of females to extreme temperatures was particularly pronounced. Similarly, both sexes increased their activity at high humidity levels during the day and low wind speeds, irrespective of the time of day, while the effect of humidity was stronger for males. Our findings highlight the importance of understanding the complex relationships between extreme weather conditions and mammal behavior, critical for conservation and management. With ongoing climate change, extreme weather events such as heat waves and heavy rainfall are predicted to occur more often and last longer. These events will directly impact the fitness of hares and other wildlife species and hence the population dynamics of already declining populations across Europe.},
  language  = {en}
}
@article{ParrySchlaegelTiedemannetal.2022,
  author    = {Parry, Victor and Schl{\"a}gel, Ulrike and Tiedemann, Ralph and Weithoff, Guntram},
  title     = {Behavioural responses of defended and undefended prey to their predator},
  series = {Biology : open access journal},
  volume    = {11},
  journal   = {Biology : open access journal},
  number    = {8},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2079-7737},
  doi       = {10.3390/biology11081217},
  pages     = {14},
  year      = {2022},
  abstract  = {Many animals that have to cope with predation have evolved mechanisms to reduce their predation risk. One of these mechanisms is change in morphology, for example, the development of spines. These spines are induced, when mothers receive chemical signals of a predator (kairomones) and their daughters are then equipped with defensive spines. We studied the behaviour of a prey and its predator when the prey is either defended or undefended. We used common aquatic micro-invertebrates, the rotifers Brachionus calyciflorus (prey) and Asplanchna brightwellii (predator) as experimental animals. We found that undefended prey increased its swimming speed in the presence of the predator. The striking result was that the defended prey did not respond to the predator's presence. This suggests that defended prey has a different response behaviour to a predator than undefended conspecifics. Our study provides further insights into complex zooplankton predator-prey interactions. Predation is a strong species interaction causing severe harm or death to prey. Thus, prey species have evolved various defence strategies to minimize predation risk, which may be immediate (e.g., a change in behaviour) or transgenerational (morphological defence structures). We studied the behaviour of two strains of a rotiferan prey (Brachionus calyciflorus) that differ in their ability to develop morphological defences in response to their predator Asplanchna brightwellii. Using video analysis, we tested: (a) if two strains differ in their response to predator presence and predator cues when both are undefended; (b) whether defended individuals respond to live predators or their cues; and (c) if the morphological defence (large spines) per se has an effect on the swimming behaviour. We found a clear increase in swimming speed for both undefended strains in predator presence. However, the defended specimens responded neither to the predator presence nor to their cues, showing that they behave indifferently to their predator when they are defended. We did not detect an effect of the spines on the swimming behaviour. Our study demonstrates a complex plastic behaviour of the prey, not only in the presence of their predator, but also with respect to their defence status.},
  language  = {en}
}
@article{ParrySchlaegelTiedemannetal.2022,
  author    = {Parry, Victor and Schl{\"a}gel, Ulrike and Tiedemann, Ralph and Weithoff, Guntram},
  title     = {Behavioural Responses of Defended and Undefended Prey to Their Predator},
  series = {Biology},
  volume    = {11},
  journal   = {Biology},
  number    = {8},
  publisher = {MDPI},
  address   = {Basel, Schweiz},
  issn      = {2079-7737},
  doi       = {10.3390/biology11081217},
  pages     = {14},
  year      = {2022},
  abstract  = {Predation is a strong species interaction causing severe harm or death to prey. Thus, prey species have evolved various defence strategies to minimize predation risk, which may be immediate (e.g., a change in behaviour) or transgenerational (morphological defence structures). We studied the behaviour of two strains of a rotiferan prey (Brachionus calyciflorus) that differ in their ability to develop morphological defences in response to their predator Asplanchna brightwellii. Using video analysis, we tested: (a) if two strains differ in their response to predator presence and predator cues when both are undefended; (b) whether defended individuals respond to live predators or their cues; and (c) if the morphological defence (large spines) per se has an effect on the swimming behaviour. We found a clear increase in swimming speed for both undefended strains in predator presence. However, the defended specimens responded neither to the predator presence nor to their cues, showing that they behave indifferently to their predator when they are defended. We did not detect an effect of the spines on the swimming behaviour. Our study demonstrates a complex plastic behaviour of the prey, not only in the presence of their predator, but also with respect to their defence status.},
  language  = {en}
}
@article{PottsSchlaegel2020,
  author    = {Potts, Jonathan R. and Schl{\"a}gel, Ulrike},
  title     = {Parametrizing diffusion-taxis equations from animal movement trajectories using step selection analysis},
  series = {Methods in ecology and evolution : an official journal of the British Ecological Society},
  volume    = {11},
  journal   = {Methods in ecology and evolution : an official journal of the British Ecological Society},
  number    = {9},
  publisher = {Wiley},
  address   = {Hoboken},
  issn      = {2041-210X},
  doi       = {10.1111/2041-210X.13406},
  pages     = {1092 -- 1105},
  year      = {2020},
  abstract  = {Mathematical analysis of partial differential equations (PDEs) has led to many insights regarding the effect of organism movements on spatial population dynamics. However, their use has mainly been confined to the community of mathematical biologists, with less attention from statistical and empirical ecologists. We conjecture that this is principally due to the inherent difficulties in fitting PDEs to data. To help remedy this situation, in the context of movement ecology, we show how the popular technique of step selection analysis (SSA) can be used to parametrize a class of PDEs, calleddiffusion-taxismodels, from an animal's trajectory. We examine the accuracy of our technique on simulated data, then demonstrate the utility of diffusion-taxis models in two ways. First, for non-interacting animals, we derive the steady-state utilization distribution in a closed analytic form. Second, we give a recipe for deriving spatial pattern formation properties that emerge from interacting animals: specifically, do those interactions cause heterogeneous spatial distributions to emerge and if so, do these distributions oscillate at short times or emerge without oscillations? The second question is applied to data on concurrently tracked bank volesMyodes glareolus. Our results show that SSA can accurately parametrize diffusion-taxis equations from location data, providing the frequency of the data is not too low. We show that the steady-state distribution of our diffusion-taxis model, where it is derived, has an identical functional form to the utilization distribution given by resource selection analysis (RSA), thus formally linking (fine scale) SSA with (broad scale) RSA. For the bank vole data, we show how our SSA-PDE approach can give predictions regarding the spatial aggregation and segregation of different individuals, which are difficult to predict purely by examining results of SSA. Our methods provide a user-friendly way into the world of PDEs, via a well-used statistical technique, which should lead to tighter links between the findings of mathematical ecology and observations from empirical ecology. By providing a non-speculative link between observed movement behaviours and space use patterns on larger spatio-temporal scales, our findings will also aid integration of movement ecology into understanding spatial species distributions.},
  language  = {en}
}
@article{HauffeRathAgyapongetal.2022,
  author    = {Hauffe, Robert and Rath, Michaela and Agyapong, Wilson and Jonas, Wenke and Vogel, Heike and Schulz, Tim Julius and Schwarz, Maria and Kipp, Anna Patricia and Bl{\"u}her, Matthias and Kleinridders, Andr{\´e}},
  title     = {Obesity Hinders the Protective Effect of Selenite Supplementation on Insulin Signaling},
  series = {Antioxidants},
  volume    = {11},
  journal   = {Antioxidants},
  edition   = {5},
  publisher = {MDPI},
  address   = {Basel, Schweiz},
  issn      = {2076-3921},
  doi       = {10.3390/antiox11050862},
  pages     = {1 -- 16},
  year      = {2022},
  abstract  = {The intake of high-fat diets (HFDs) containing large amounts of saturated long-chain fatty acids leads to obesity, oxidative stress, inflammation, and insulin resistance. The trace element selenium, as a crucial part of antioxidative selenoproteins, can protect against the development of diet-induced insulin resistance in white adipose tissue (WAT) by increasing glutathione peroxidase 3 (GPx3) and insulin receptor (IR) expression. Whether selenite (Se) can attenuate insulin resistance in established lipotoxic and obese conditions is unclear. We confirm that GPX3 mRNA expression in adipose tissue correlates with BMI in humans. Cultivating 3T3-L1 pre-adipocytes in palmitate-containing medium followed by Se treatment attenuates insulin resistance with enhanced GPx3 and IR expression and adipocyte differentiation. However, feeding obese mice a selenium-enriched high-fat diet (SRHFD) only resulted in a modest increase in overall selenoprotein gene expression in WAT in mice with unaltered body weight development, glucose tolerance, and insulin resistance. While Se supplementation improved adipocyte morphology, it did not alter WAT insulin sensitivity. However, mice fed a SRHFD exhibited increased insulin content in the pancreas. Overall, while selenite protects against palmitate-induced insulin resistance in vitro, obesity impedes the effect of selenite on insulin action and adipose tissue metabolism in vivo.},
  language  = {en}
}
@article{FischerBrettinRoessneretal.2022,
  author    = {Fischer, Melanie and Brettin, Jana and Roessner, Sigrid and Walz, Ariane and Fort, Monique and Korup, Oliver},
  title     = {Rare flood scenarios for a rapidly growing high-mountain city: Pokhara, Nepal},
  series = {Natural Hazards and Earth System Sciences},
  volume    = {22},
  journal   = {Natural Hazards and Earth System Sciences},
  edition   = {9},
  publisher = {Copernicus Publications},
  address   = {Katlenburg-Lindau},
  issn      = {1684-9981},
  doi       = {10.5194/nhess-22-3105-2022},
  pages     = {3105 -- 3123},
  year      = {2022},
  abstract  = {Pokhara (ca. 850 m a.s.l.), Nepal's second-largest city, lies at the foot of the Higher Himalayas and has more than tripled its population in the past 3 decades. Construction materials are in high demand in rapidly expanding built-up areas, and several informal settlements cater to unregulated sand and gravel mining in the Pokhara Valley's main river, the Seti Khola. This river is fed by the Sabche glacier below Annapurna III (7555 m a.s.l.), some 35 km upstream of the city, and traverses one of the steepest topographic gradients in the Himalayas. In May 2012 a sudden flood caused >70 fatalities and intense damage along this river and rekindled concerns about flood risk management. We estimate the flow dynamics and inundation depths of flood scenarios using the hydrodynamic model HEC-RAS (Hydrologic Engineering Center's River Analysis System). We simulate the potential impacts of peak discharges from 1000 to 10 000 m3 s-1 on land cover based on high-resolution Maxar satellite imagery and OpenStreetMap data (buildings and road network). We also trace the dynamics of two informal settlements near Kaseri and Yamdi with high potential flood impact from RapidEye, PlanetScope, and Google Earth imagery of the past 2 decades. Our hydrodynamic simulations highlight several sites of potential hydraulic ponding that would largely affect these informal settlements and sites of sand and gravel mining. These built-up areas grew between 3- and 20-fold, thus likely raising local flood exposure well beyond changes in flood hazard. Besides these drastic local changes, about 1 \% of Pokhara's built-up urban area and essential rural road network is in the highest-hazard zones highlighted by our flood simulations. Our results stress the need to adapt early-warning strategies for locally differing hydrological and geomorphic conditions in this rapidly growing urban watershed.},
  language  = {en}
}
@article{PalyulinBlackburnLomholtetal.2019,
  author    = {Palyulin, Vladimir V. and Blackburn, George and Lomholt, Michael A. and Watkins, Nicholas W. and Metzler, Ralf and Klages, Rainer and Chechkin, Aleksei},
  title     = {First passage and first hitting times of Levy flights and Levy walks},
  series = {New journal of physics : the open-access journal for physics},
  volume    = {21},
  journal   = {New journal of physics : the open-access journal for physics},
  number    = {10},
  publisher = {IOP Publ. Ltd.},
  address   = {Bristol},
  issn      = {1367-2630},
  doi       = {10.1088/1367-2630/ab41bb},
  pages     = {23},
  year      = {2019},
  abstract  = {For both L{\´e}vy flight and L{\´e}vy walk search processes we analyse the full distribution of first-passage and first-hitting (or first-arrival) times. These are, respectively, the times when the particle moves across a point at some given distance from its initial position for the first time, or when it lands at a given point for the first time. For L{\´e}vy motions with their propensity for long relocation events and thus the possibility to jump across a given point in space without actually hitting it ('leapovers'), these two definitions lead to significantly different results. We study the first-passage and first-hitting time distributions as functions of the L{\´e}vy stable index, highlighting the different behaviour for the cases when the first absolute moment of the jump length distribution is finite or infinite. In particular we examine the limits of short and long times. Our results will find their application in the mathematical modelling of random search processes as well as computer algorithms.},
  language  = {en}
}
@article{GonzalezHauckHerrmannHettihewaetal.2022,
  author    = {Gonz{\´a}lez Hauck, Su{\´e} and Herrmann, Franziska M. and Hettihewa, Julian A. and Kraft, Dariush and Milas, Max and Springer, Stephanie and Weckner, Franka},
  title     = {Jurisdiction},
  series = {Zeitschrift f{\"u}r ausl{\"a}ndisches {\"o}ffentliches Recht und V{\"o}lkerrecht},
  volume    = {82},
  journal   = {Zeitschrift f{\"u}r ausl{\"a}ndisches {\"o}ffentliches Recht und V{\"o}lkerrecht},
  number    = {2},
  publisher = {C.H. Beck},
  address   = {M{\"u}nchen},
  issn      = {0044-2348},
  doi       = {10.17104/0044-2348-2022-2-289},
  pages     = {289 -- 298},
  year      = {2022},
  language  = {en}
}
@article{BergholzKoberJeltschetal.2021,
  author    = {Bergholz, Kolja and Kober, Klarissa and Jeltsch, Florian and Schmidt, Kristina and Weiß, Lina},
  title     = {Trait means or variance},
  series = {Ecology and evolution},
  volume    = {11},
  journal   = {Ecology and evolution},
  number    = {7},
  publisher = {John Wiley \& Sons, Inc.},
  issn      = {2045-7758},
  doi       = {10.1002/ece3.7287},
  pages     = {3357 -- 3365},
  year      = {2021},
  abstract  = {One of the few laws in ecology is that communities consist of few common and many rare taxa. Functional traits may help to identify the underlying mechanisms of this community pattern, since they correlate with different niche dimensions. However, comprehensive studies are missing that investigate the effects of species mean traits (niche position) and intraspecific trait variability (ITV, niche width) on species abundance. In this study, we investigated fragmented dry grasslands to reveal trait-occurrence relationships in plants at local and regional scales. We predicted that (a) at the local scale, species occurrence is highest for species with intermediate traits, (b) at the regional scale, habitat specialists have a lower species occurrence than generalists, and thus, traits associated with stress-tolerance have a negative effect on species occurrence, and (c) ITV increases species occurrence irrespective of the scale. We measured three plant functional traits (SLA = specific leaf area, LDMC = leaf dry matter content, plant height) at 21 local dry grassland communities (10 m × 10 m) and analyzed the effect of these traits and their variation on species occurrence. At the local scale, mean LDMC had a positive effect on species occurrence, indicating that stress-tolerant species are the most abundant rather than species with intermediate traits (hypothesis 1). We found limited support for lower specialist occurrence at the regional scale (hypothesis 2). Further, ITV of LDMC and plant height had a positive effect on local occurrence supporting hypothesis 3. In contrast, at the regional scale, plants with a higher ITV of plant height were less frequent. We found no evidence that the consideration of phylogenetic relationships in our analyses influenced our findings. In conclusion, both species mean traits (in particular LDMC) and ITV were differently related to species occurrence with respect to spatial scale. Therefore, our study underlines the strong scale-dependency of trait-abundance relationships.},
  language  = {en}
}
@article{BergholzSittelRistowetal.2022,
  author    = {Bergholz, Kolja and Sittel, Lara-Pauline and Ristow, Michael and Jeltsch, Florian and Weiß, Lina},
  title     = {Pollinator guilds respond contrastingly at different scales to landscape parameters of land-use intensity},
  series = {Ecology and evolution},
  volume    = {12},
  journal   = {Ecology and evolution},
  number    = {3},
  publisher = {Wiley},
  address   = {Hoboken},
  issn      = {2045-7758},
  doi       = {10.1002/ece3.8708},
  pages     = {11},
  year      = {2022},
  abstract  = {Land-use intensification is the main factor for the catastrophic decline of insect pollinators. However, land-use intensification includes multiple processes that act across various scales and should affect pollinator guilds differently depending on their ecology. We aimed to reveal how two main pollinator guilds, wild bees and hoverflies, respond to different land-use intensification measures, that is, arable field cover (AFC), landscape heterogeneity (LH), and functional flower composition of local plant communities as a measure of habitat quality. We sampled wild bees and hoverflies on 22 dry grassland sites within a highly intensified landscape (NE Germany) within three campaigns using pan traps. We estimated AFC and LH on consecutive radii (60-3000 m) around the dry grassland sites and estimated the local functional flower composition. Wild bee species richness and abundance was positively affected by LH and negatively by AFC at small scales (140-400 m). In contrast, hoverflies were positively affected by AFC and negatively by LH at larger scales (500-3000 m), where both landscape parameters were negatively correlated to each other. At small spatial scales, though, LH had a positive effect on hoverfly abundance. Functional flower diversity had no positive effect on pollinators, but conspicuous flowers seem to attract abundance of hoverflies. In conclusion, landscape parameters contrarily affect two pollinator guilds at different scales. The correlation of landscape parameters may influence the observed relationships between landscape parameters and pollinators. Hence, effects of land-use intensification seem to be highly landscape-specific.},
  language  = {en}
}
@article{PetrichAjiDunsingetal.2023,
  author    = {Petrich, Annett and Aji, Amit Koikkarah and Dunsing, Valentin and Chiantia, Salvatore},
  title     = {Benchmarking of novel green fluorescent proteins for the quantification of protein oligomerization in living cells},
  series = {PLoS one},
  volume    = {18},
  journal   = {PLoS one},
  number    = {8},
  publisher = {PLoS},
  address   = {San Fransisco},
  issn      = {1932-6203},
  doi       = {10.1371/journal.pone.0285486},
  pages     = {13},
  year      = {2023},
  abstract  = {Protein-protein-interactions play an important role in many cellular functions. Quantitative non-invasive techniques are applied in living cells to evaluate such interactions, thereby providing a broader understanding of complex biological processes. Fluorescence fluctuation spectroscopy describes a group of quantitative microscopy approaches for the characterization of molecular interactions at single cell resolution. Through the obtained molecular brightness, it is possible to determine the oligomeric state of proteins. This is usually achieved by fusing fluorescent proteins (FPs) to the protein of interest. Recently, the number of novel green FPs has increased, with consequent improvements to the quality of fluctuation-based measurements. The photophysical behavior of FPs is influenced by multiple factors (including photobleaching, protonation-induced "blinking" and long-lived dark states). Assessing these factors is critical for selecting the appropriate fluorescent tag for live cell imaging applications. In this work, we focus on novel green FPs that are extensively used in live cell imaging. A systematic performance comparison of several green FPs in living cells under different pH conditions using Number \& Brightness (N \& B) analysis and scanning fluorescence correlation spectroscopy was performed. Our results show that the new FP Gamillus exhibits higher brightness at the cost of lower photostability and fluorescence probability (pf), especially at lower pH. mGreenLantern, on the other hand, thanks to a very high pf, is best suited for multimerization quantification at neutral pH. At lower pH, mEGFP remains apparently the best choice for multimerization investigation. These guidelines provide the information needed to plan quantitative fluorescence microscopy involving these FPs, both for general imaging or for protein-protein-interactions quantification via fluorescence fluctuation-based methods.},
  language  = {en}
}
@article{GenderjahnLewinHornetal.2021,
  author    = {Genderjahn, Steffi and Lewin, Simon and Horn, Fabian and Schleicher, Anja M. and Mangelsdorf, Kai and Wagner, Dirk},
  title     = {Living lithic and sublithic bacterial communities in Namibian drylands},
  series = {Microorganisms : open access journal},
  volume    = {9},
  journal   = {Microorganisms : open access journal},
  number    = {2},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2076-2607},
  doi       = {10.3390/microorganisms9020235},
  pages     = {20},
  year      = {2021},
  abstract  = {Dryland xeric conditions exert a deterministic effect on microbial communities, forcing life into refuge niches. Deposited rocks can form a lithic niche for microorganisms in desert regions. Mineral weathering is a key process in soil formation and the importance of microbial-driven mineral weathering for nutrient extraction is increasingly accepted. Advances in geobiology provide insight into the interactions between microorganisms and minerals that play an important role in weathering processes. In this study, we present the examination of the microbial diversity in dryland rocks from the Tsauchab River banks in Namibia. We paired culture-independent 16S rRNA gene amplicon sequencing with culture-dependent (isolation of bacteria) techniques to assess the community structure and diversity patterns. Bacteria isolated from dryland rocks are typical of xeric environments and are described as being involved in rock weathering processes. For the first time, we extracted extra- and intracellular DNA from rocks to enhance our understanding of potentially rock-weathering microorganisms. We compared the microbial community structure in different rock types (limestone, quartz-rich sandstone and quartz-rich shale) with adjacent soils below the rocks. Our results indicate differences in the living lithic and sublithic microbial communities.},
  language  = {en}
}
@article{SchuckSchleicherJanssenetal.2020,
  author    = {Schuck, Bernhard and Schleicher, Anja M. and Janssen, Christoph and Toy, Virginia G. and Dresen, Georg},
  title     = {Fault zone architecture of a large plate-bounding strike-slip fault},
  series = {Solid Earth},
  volume    = {11},
  journal   = {Solid Earth},
  number    = {1},
  publisher = {Copernicus Publications},
  address   = {G{\"o}ttingen},
  issn      = {1869-9529},
  doi       = {10.5194/se-11-95-2020},
  pages     = {95 -- 124},
  year      = {2020},
  abstract  = {New Zealand's Alpine Fault is a large, platebounding strike-slip fault, which ruptures in large (M-w > 8) earthquakes. We conducted field and laboratory analyses of fault rocks to assess its fault zone architecture. Results reveal that the Alpine Fault Zone has a complex geometry, comprising an anastomosing network of multiple slip planes that have accommodated different amounts of displacement. This contrasts with the previous perception of the Alpine Fault Zone, which assumes a single principal slip zone accommodated all displacement. This interpretation is supported by results of drilling projects and geophysical investigations. Furthermore, observations presented here show that the young, largely unconsolidated sediments that constitute the footwall at shallow depths have a significant influence on fault gouge rheological properties and structure.},
  language  = {en}
}
@article{BergholzSittelRistowetal.2022,
  author    = {Bergholz, Kolja and Sittel, Lara-Pauline and Ristow, Michael and Jeltsch, Florian and Weiß, Lina},
  title     = {Pollinator guilds respond contrastingly at different scales to landscape parameters of land-use intensity},
  series = {Ecology and Evolution},
  volume    = {12},
  journal   = {Ecology and Evolution},
  number    = {3},
  publisher = {John Wiley \& Sons, Inc.},
  address   = {Hoboken (New Jersey)},
  issn      = {2045-7758},
  doi       = {10.1002/ece3.8708},
  pages     = {11},
  year      = {2022},
  abstract  = {Land-use intensification is the main factor for the catastrophic decline of insect pollinators. However, land-use intensification includes multiple processes that act across various scales and should affect pollinator guilds differently depending on their ecology. We aimed to reveal how two main pollinator guilds, wild bees and hoverflies, respond to different land-use intensification measures, that is, arable field cover (AFC), landscape heterogeneity (LH), and functional flower composition of local plant communities as a measure of habitat quality. We sampled wild bees and hoverflies on 22 dry grassland sites within a highly intensified landscape (NE Germany) within three campaigns using pan traps. We estimated AFC and LH on consecutive radii (60-3000 m) around the dry grassland sites and estimated the local functional flower composition. Wild bee species richness and abundance was positively affected by LH and negatively by AFC at small scales (140-400 m). In contrast, hoverflies were positively affected by AFC and negatively by LH at larger scales (500-3000 m), where both landscape parameters were negatively correlated to each other. At small spatial scales, though, LH had a positive effect on hoverfly abundance. Functional flower diversity had no positive effect on pollinators, but conspicuous flowers seem to attract abundance of hoverflies. In conclusion, landscape parameters contrarily affect two pollinator guilds at different scales. The correlation of landscape parameters may influence the observed relationships between landscape parameters and pollinators. Hence, effects of land-use intensification seem to be highly landscape-specific.},
  language  = {en}
}
@article{KumarLeimkuehler2023,
  author    = {Kumar, Hemant and Leimk{\"u}hler, Silke},
  title     = {Changing the electron acceptor specificity of rhodobacter capsulatus formate dehydrogenase from NAD+ to NADP+},
  series = {International journal of molecular sciences},
  volume    = {24},
  journal   = {International journal of molecular sciences},
  number    = {22},
  publisher = {Molecular Diversity Preservation International},
  address   = {Basel},
  issn      = {1422-0067},
  doi       = {10.3390/ijms242216067},
  pages     = {13},
  year      = {2023},
  abstract  = {Formate dehydrogenases catalyze the reversible oxidation of formate to carbon dioxide. These enzymes play an important role in CO2 reduction and serve as nicotinamide cofactor recycling enzymes. More recently, the CO2-reducing activity of formate dehydrogenases, especially metal-containing formate dehydrogenases, has been further explored for efficient atmospheric CO2 capture. Here, we investigate the nicotinamide binding site of formate dehydrogenase from Rhodobacter capsulatus for its specificity toward NAD+ vs. NADP+ reduction. Starting from the NAD+-specific wild-type RcFDH, key residues were exchanged to enable NADP+ binding on the basis of the NAD+-bound cryo-EM structure (PDB-ID: 6TG9). It has been observed that the lysine at position 157 (Lys157) in the β-subunit of the enzyme is essential for the binding of NAD+. RcFDH variants that had Glu259 exchanged for either a positively charged or uncharged amino acid had additional activity with NADP+. The FdsBL279R and FdsBK276A variants also showed activity with NADP+. Kinetic parameters for all the variants were determined and tested for activity in CO2 reduction. The variants were able to reduce CO2 using NADPH as an electron donor in a coupled assay with phosphite dehydrogenase (PTDH), which regenerates NADPH. This makes the enzyme suitable for applications where it can be coupled with other enzymes that use NADPH.},
  language  = {en}
}
@article{KonakDoeringFiedleretal.2023,
  author    = {Konak, Orhan and D{\"o}ring, Valentin and Fiedler, Tobias and Liebe, Lucas and Masopust, Leander and Postnov, Kirill and Sauerwald, Franz and Treykorn, Felix and Wischmann, Alexander and Kalabakov, Stefan and Gjoreski, Hristijan and Luštrek, Mitja and Arnrich, Bert},
  title     = {SONAR},
  series = {Scientific data},
  volume    = {10},
  journal   = {Scientific data},
  number    = {1},
  publisher = {Nature Publ. Group},
  address   = {London},
  issn      = {2052-4463},
  doi       = {10.1038/s41597-023-02620-2},
  pages     = {12},
  year      = {2023},
  abstract  = {Accurate and comprehensive nursing documentation is essential to ensure quality patient care. To streamline this process, we present SONAR, a publicly available dataset of nursing activities recorded using inertial sensors in a nursing home. The dataset includes 14 sensor streams, such as acceleration and angular velocity, and 23 activities recorded by 14 caregivers using five sensors for 61.7 hours. The caregivers wore the sensors as they performed their daily tasks, allowing for continuous monitoring of their activities. We additionally provide machine learning models that recognize the nursing activities given the sensor data. In particular, we present benchmarks for three deep learning model architectures and evaluate their performance using different metrics and sensor locations. Our dataset, which can be used for research on sensor-based human activity recognition in real-world settings, has the potential to improve nursing care by providing valuable insights that can identify areas for improvement, facilitate accurate documentation, and tailor care to specific patient conditions.},
  language  = {en}
}
@article{BoginHermanussenScheffler2022,
  author    = {Bogin, Barry and Hermanussen, Michael and Scheffler, Christiane},
  title     = {Bergmann's rule is a "just-so" story of human body size},
  series = {Journal of physiological anthropology},
  volume    = {41},
  journal   = {Journal of physiological anthropology},
  number    = {1},
  publisher = {BMC},
  address   = {London},
  issn      = {1880-6805},
  doi       = {10.1186/s40101-022-00287-z},
  pages     = {13},
  year      = {2022},
  abstract  = {Carl Bergmann was an astute naturalist and physiologist. His ideas about animal size and shape were important advances in the pre-Darwinian nineteenth century. Bergmann's rule claims that that in cold climates, large body mass increases the ratio of volume-to-surface area and provides for maximum metabolic heat retention in mammals and birds. Conversely, in warmer temperatures, smaller body mass increases surface area relative to volume and allows for greater heat loss. For humans, we now know that body size and shape are regulated more by social-economic-political-emotional (SEPE) factors as well as nutrition-infection interactions. Temperature has virtually no effect. Bergmann's rule is a "just-so" story and should be relegated to teaching and scholarship about the history of science. That "rule" is no longer acceptable science and has nothing to tell us about physiological anthropology.},
  language  = {en}
}
@article{BergholzBalthasarWeissetal.2023,
  author    = {Bergholz, Kolja and Balthasar, Cathrina and Weiss, Anne-Marie and Brunkhardt, Jennifer and Ristow, Michael and Weiß, Lina},
  title     = {Niche differentiation of arthropods and plants along small-scale gradients in temporary wetlands (kettle holes)},
  series = {Basic and applied ecology : journal of the Gesellschaft f{\"u}r {\"O}kologie},
  volume    = {73},
  journal   = {Basic and applied ecology : journal of the Gesellschaft f{\"u}r {\"O}kologie},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1439-1791},
  doi       = {10.1016/j.baae.2023.10.003},
  pages     = {10 -- 17},
  year      = {2023},
  abstract  = {Small temporary wetlands, like kettle holes, provide many valuable ecosystem functions and serve as refuge habitats in otherwise monotonous agricultural landscapes. However, the mechanisms that maintain biodiversity in these habitats are still poorly understood. In this study, we investigate how three taxa (vascular plants, ground beetles and spiders) respond to small-scale flooding and disturbance gradients in kettle holes as well as kettle hole area. For this purpose, we determined total, hygrophilic and red list species richness for all taxa and activity density for arthropods along transects extending from the edge towards the center of kettle holes. Furthermore, we calculated the community-weighted mean body size for arthropods and seed mass for plants as surrogates for the ability to respond to disturbance. Our analyses revealed that in particular plants and ground beetles showed strong responses along the small-scale spatial gradient. Total plant species richness decreased towards the center, while hygrophilic plant species increased. In contrast, both total and hygrophilic species richness of ground beetles increased towards the center. Spiders showed similar responses as ground beetles, but less pronounced. We found no evidence that disturbance at the edge of kettle holes leads to smaller body sizes or seed masses. However, arthropods in adjacent arable fields (one meter from the kettle hole edge) were particularly small. Kettle hole area had only weak effects on plants, but not on arthropods. Our study indicates that differences in the depth at the drier edge and the moist, regularly flooded center have a large and taxon-dependent influence on the species composition. Therefore, small-scale heterogeneity seems to be an important predictor for the maintenance of species diversity.},
  language  = {en}
}
@article{WittekToumaNitezkietal.2023,
  author    = {Wittek, Laura and Touma, Chadi and Nitezki, Tina and Laeger, Thomas and Kr{\"a}mer, Stephanie and Raila, Jens},
  title     = {Reduction in cold stress in an innovative metabolic cage housing system increases animal welfare in laboratory mice},
  series = {Animals},
  volume    = {13},
  journal   = {Animals},
  number    = {18},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2076-2615},
  doi       = {10.3390/ani13182866},
  pages     = {21},
  year      = {2023},
  abstract  = {Housing in metabolic cages can induce a pronounced stress response. Metabolic cage systems imply housing mice on metal wire mesh for the collection of urine and feces in addition to monitoring food and water intake. Moreover, mice are single-housed, and no nesting, bedding, or enrichment material is provided, which is often argued to have a not negligible impact on animal welfare due to cold stress. We therefore attempted to reduce stress during metabolic cage housing for mice by comparing an innovative metabolic cage (IMC) with a commercially available metabolic cage from Tecniplast GmbH (TMC) and a control cage. Substantial refinement measures were incorporated into the IMC cage design. In the frame of a multifactorial approach for severity assessment, parameters such as body weight, body composition, food intake, cage and body surface temperature (thermal imaging), mRNA expression of uncoupling protein 1 (Ucp1) in brown adipose tissue (BAT), fur score, and fecal corticosterone metabolites (CMs) were included. Female and male C57BL/6J mice were single-housed for 24 h in either conventional Macrolon cages (control), IMC, or TMC for two sessions. Body weight decreased less in the IMC (females—1st restraint: -6.94\%; 2nd restraint: -6.89\%; males—1st restraint: -8.08\%; 2nd restraint: -5.82\%) compared to the TMC (females—1st restraint: -13.2\%; 2nd restraint: -15.0\%; males—1st restraint: -13.1\%; 2nd restraint: -14.9\%) and the IMC possessed a higher cage temperature (females—1st restraint: 23.7 °C; 2nd restraint: 23.5 °C; males—1st restraint: 23.3 °C; 2nd restraint: 23.5 °C) compared with the TMC (females—1st restraint: 22.4 °C; 2nd restraint: 22.5 °C; males—1st restraint: 22.6 °C; 2nd restraint: 22.4 °C). The concentration of fecal corticosterone metabolites in the TMC (females—1st restraint: 1376 ng/g dry weight (DW); 2nd restraint: 2098 ng/g DW; males—1st restraint: 1030 ng/g DW; 2nd restraint: 1163 ng/g DW) was higher compared to control cage housing (females—1st restraint: 640 ng/g DW; 2nd restraint: 941 ng/g DW; males—1st restraint: 504 ng/g DW; 2nd restraint: 537 ng/g DW). Our results show the stress potential induced by metabolic cage restraint that is markedly influenced by the lower housing temperature. The IMC represents a first attempt to target cold stress reduction during metabolic cage application thereby producing more animal welfare friendlydata.},
  language  = {en}
}
@article{HermanussenDammhahnScheffleretal.2023,
  author    = {Hermanussen, Michael and Dammhahn, Melanie and Scheffler, Christiane and Groth, Detlef},
  title     = {Winner-loser effects improve social network efficiency between competitors with equal resource holding power},
  series = {Scientific reports},
  volume    = {13},
  journal   = {Scientific reports},
  number    = {1},
  publisher = {Springer Nature},
  address   = {London},
  issn      = {2045-2322},
  doi       = {10.1038/s41598-023-41225-y},
  pages     = {9},
  year      = {2023},
  abstract  = {Animal societies are structured of dominance hierarchy (DH). DH can be viewed as networks and analyzed by graph theory. We study the impact of state-dependent feedback (winner-loser effect) on the emergence of local dominance structures after pairwise contests between initially equal-ranking members (equal resource-holding-power, RHP) of small and large social groups. We simulated pairwise agonistic contests between individuals with and without a priori higher RHP by Monte-Carlo-method. Random pairwise contests between equal-ranking competitors result in random dominance structures ('Null variant') that are low in transitive triads and high in pass along triads; whereas state-dependent feedback ('Winner-loser variant') yields centralized 'star' structured DH that evolve from competitors with initially equal RHP and correspond to hierarchies that evolve from keystone individuals. Monte-Carlo simulated DH following state-dependent feedback show motif patterns very similar to those of a variety of natural DH, suggesting that state-dependent feedback plays a pivotal role in robust self-organizing phenomena that transcend the specifics of the individual. Self-organization based on state-dependent feedback leads to social structures that correspond to those resulting from pre-existing keystone individuals. As the efficiency of centralized social networks benefits both, the individual and the group, centralization of social networks appears to be an important evolutionary goal.},
  language  = {en}
}
@article{MachinPiontekTodheetal.2022,
  author    = {Machin, Laura and Piontek, Martin and Todhe, Sara and Staniek, Katrin and Monzote, Lianet and Fudickar, Werner and Linker, Torsten and Gille, Lars},
  title     = {Antileishmanial anthracene endoperoxides: efficacy in vitro, mechanisms and structure-activity relationships},
  series = {Molecules : a journal of synthetic chemistry and natural product chemistry},
  volume    = {27},
  journal   = {Molecules : a journal of synthetic chemistry and natural product chemistry},
  number    = {20},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {1420-3049},
  doi       = {10.3390/molecules27206846},
  pages     = {22},
  year      = {2022},
  abstract  = {Leishmaniasis is a vector-borne disease caused by protozoal Leishmania parasites. Previous studies have shown that endoperoxides (EP) can selectively kill Leishmania in host cells. Therefore, we studied in this work a set of new anthracene-derived EP (AcEP) together with their non-endoperoxidic analogs in model systems of Leishmania tarentolae promastigotes (LtP) and J774 macrophages for their antileishmanial activity and selectivity. The mechanism of effective compounds was explored by studying their reaction with iron (II) in chemical systems and in Leishmania. The correlation of structural parameters with activity demonstrated that in this compound set, active compounds had a LogP(OW) larger than 3.5 and a polar surface area smaller than 100 angstrom(2). The most effective compounds (IC50 in LtP < 2 mu M) with the highest selectivity (SI > 30) were pyridyl-/tert-butyl-substituted AcEP. Interestingly, also their analogs demonstrated activity and selectivity. In mechanistic studies, it was shown that EP were activated by iron in chemical systems and in LtP due to their EP group. However, the molecular structure beyond the EP group significantly contributed to their differential mitochondrial inhibition in Leishmania. The identified compound pairs are a good starting point for subsequent experiments in pathogenic Leishmania in vitro and in animal models.},
  language  = {en}
}
@article{HartmannGoetzkeDuestereretal.2022,
  author    = {Hartmann, Gregor and Goetzke, Gesa and D{\"u}sterer, Stefan and Feuer-Forson, Peter and Lever, Fabiano and Meier, David and M{\"o}ller, Felix and Ramirez, Luis Vera and G{\"u}hr, Markus and Tiedtke, Kai and Viefhaus, Jens and Braune, Markus},
  title     = {Unsupervised real-world knowledge extraction via disentangled variational autoencoders for photon diagnostics},
  series = {Scientific reports},
  volume    = {12},
  journal   = {Scientific reports},
  number    = {1},
  publisher = {Springer Nature},
  address   = {London},
  issn      = {2045-2322},
  doi       = {10.1038/s41598-022-25249-4},
  pages     = {10},
  year      = {2022},
  abstract  = {We present real-world data processing on measured electron time-of-flight data via neural networks. Specifically, the use of disentangled variational autoencoders on data from a diagnostic instrument for online wavelength monitoring at the free electron laser FLASH in Hamburg. Without a-priori knowledge the network is able to find representations of single-shot FEL spectra, which have a low signal-to-noise ratio. This reveals, in a directly human-interpretable way, crucial information about the photon properties. The central photon energy and the intensity as well as very detector-specific features are identified. The network is also capable of data cleaning, i.e. denoising, as well as the removal of artefacts. In the reconstruction, this allows for identification of signatures with very low intensity which are hardly recognisable in the raw data. In this particular case, the network enhances the quality of the diagnostic analysis at FLASH. However, this unsupervised method also has the potential to improve the analysis of other similar types of spectroscopy data.},
  language  = {en}
}
@article{BondueHollTrommleretal.2022,
  author    = {Bond{\"u}, Rebecca and Holl, Anna K. and Trommler, Denny and Schmitt, Manfred J.},
  title     = {Responses toward injustice shaped by justice sensitivity - evidence from Germany},
  series = {Frontiers in psychology},
  volume    = {13},
  journal   = {Frontiers in psychology},
  publisher = {Frontiers Media},
  address   = {Lausanne},
  issn      = {1664-1078},
  doi       = {10.3389/fpsyg.2022.858291},
  pages     = {19},
  year      = {2022},
  abstract  = {Anger, indignation, guilt, rumination, victim compensation, and perpetrator punishment are considered primary responses associated with justice sensitivity (JS). However, injustice and high JS may predispose to further responses. We had N = 293 adults rate their JS, 17 potential responses toward 12 unjust scenarios from the victim's, observer's, beneficiary's, and perpetrator's perspectives, and several control variables. Unjust situations generally elicited many affective, cognitive, and behavioral responses. JS generally predisposed to strong affective responses toward injustice, including sadness, pity, disappointment, and helplessness. It impaired trivialization, victim-blaming, or justification, which may otherwise help cope with injustice. It predisposed to conflict solutions and victim compensation. Particularly victim and beneficiary JS had stronger effects in unjust situations from the corresponding perspective. These findings add to a better understanding of the main and interaction effects of unjust situations from different perspectives and the JS facets, differences between the JS facets, as well as the links between JS and behavior and well-being.},
  language  = {en}
}
@article{DordevicMaileDasetal.2023,
  author    = {Dordevic, Milos and Maile, Olga and Das, Anustup and Kundu, Sumit and Haun, Carolin and Baier, Bernhard and M{\"u}ller, Notger Germar},
  title     = {A comparison of immersive vs. non-immersive virtual reality exercises for the upper limb},
  series = {Journal of Clinical Medicine : open access journal},
  volume    = {12},
  journal   = {Journal of Clinical Medicine : open access journal},
  number    = {18},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2077-0383},
  doi       = {10.3390/jcm12185781},
  pages     = {10},
  year      = {2023},
  abstract  = {Functional near-infrared spectroscopy (fNIRS) allows for a reliable assessment of oxygenated blood flow in relevant brain regions. Recent advancements in immersive virtual reality (VR)-based technology have generated many new possibilities for its application, such as in stroke rehabilitation. In this study, we asked whether there is a difference in oxygenated hemoglobin (HbO2) within brain motor areas during hand/arm movements between immersive and non-immersive VR settings. Ten healthy young participants (24.3 ± 3.7, three females) were tested using a specially developed VR paradigm, called "bus riding", whereby participants used their hand to steer a moving bus. Both immersive and non-immersive conditions stimulated brain regions controlling hand movements, namely motor cortex, but no significant differences in HbO2 could be found between the two conditions in any of the relevant brain regions. These results are to be interpreted with caution, as only ten participants were included in the study.},
  language  = {en}
}
@article{RezaeiTimmermanMoazzenetal.2023,
  author    = {Rezaei, Leila and Timmerman, Martin Jan and Moazzen, Mohssen and Altenberger, Uwe and Sl{\´a}ma, Jiř{\´i} and Sudo, Masafumi and G{\"u}nter, Christina and Wilke, Franziska Daniela Helena and Schleicher, Anja M.},
  title     = {Mid-cretaceous extensional magmatism in the Alborz Mountains, north Iran},
  series = {Swiss journal of geosciences},
  volume    = {116},
  journal   = {Swiss journal of geosciences},
  publisher = {Birkh{\"a}user},
  address   = {Basel},
  issn      = {1661-8734},
  doi       = {10.1186/s00015-023-00443-2},
  pages     = {21},
  year      = {2023},
  abstract  = {In the Gasht-Masuleh area in the Alborz Mountains, gabbroic magma intruded Palaeozoic metasediments and Mesozoic sediments and crystallised as isotropic and cumulate gabbros. LREE enrichment points to relatively low degrees of mantle melting and depletion of Ti, Nb and Ta relative to primitive mantle points to an arc related component in the magma. Clinopyroxene compositions indicate MORB to arc signatures. U-Pb zircon crystallisation ages of 99.5 ± 0.6 Ma and 99.4 ± 0.6 Ma and phlogopite 40Ar/39Ar ages of 97.1 ± 0.4 Ma, 97.5 ± 0.4 Ma, 97.1 ± 0.1 Ma, within 2σ error, indicate that gabbro intrusion occurred in the (Albian-)Cenomanian (mid-Cretaceous). As active subduction did not take place in the Cretaceous in North Iran, the small volume mafic magmatism in the Gasht-Masuleh area must be due to local, extension-related mantle melting. Melting was most likely caused by far field effects triggered by roll-back of the Neo-Tethys subducting slab. As subduction took place at a distance of ~ 400 km (present distance) from the Alborz Mountains, the observed arc geochemical signatures must be inherited from a previous subduction event and concomitant mantle metasomatism, possibly in combination with contamination of the magma by crustal material.},
  language  = {en}
}
@article{HaltaufderheideLuchtStruencketal.2023,
  author    = {Haltaufderheide, Joschka and Lucht, Annika and Str{\"u}nck, Christoph and Vollmann, Jochen},
  title     = {Increasing efficiency and well-being?},
  series = {BMC medical ethics},
  volume    = {24},
  journal   = {BMC medical ethics},
  number    = {1},
  publisher = {BioMed Central},
  address   = {London},
  issn      = {1472-6939},
  doi       = {10.1186/s12910-023-00984-z},
  pages     = {14},
  year      = {2023},
  abstract  = {Background: Socially assistive devices (care robots, companions, smart screen assistants) have been advocated as a promising tool in elderly care in Western healthcare systems. Ethical debates indicate various challenges. One of the most prevalent arguments in the debate is the double-benefit argument claiming that socially assistive devices may not only provide benefits for autonomy and well-being of their users but might also be more efficient than other caring practices and might help to mitigate scarce resources in healthcare. Against this background, we used a subset of comparative empirical studies from a comprehensive systematic review on effects and perceptions of human-machine interaction with socially assistive devices to gather and appraise all available evidence supporting this argument from the empirical side. Methods: Electronic databases and additional sources were queried using a comprehensive search strategy which generated 9851 records. Studies were screened independently by two authors. Methodological quality of studies was assessed. For 39 reports using a comparative study design, a narrative synthesis was performed. Results: The data shows positive evidential support to claim that some socially assistive devices (Paro) might be able to contribute to the well-being and autonomy of their users. However, results also indicate that these positive findings may be heavily dependent on the context of use and the population. In addition, we found evidence that socially assistive devices can have negative effects on certain populations. Evidence regarding the claim of efficiency is scarce. Existing results indicate that socially assistive devices can be more effective than standard of care but are far less effective than plush toys or placebo devices. Discussion: We suggest using the double-benefit argument with great caution as it is not supported by the currently available evidence. The occurrence of potentially negative effects of socially assistive devices requires more research and indicates a more complex ethical calculus than suggested by the double-benefit argument.},
  language  = {en}
}
@article{SchoedlOdemerBecheretal.2022,
  author    = {Sch{\"o}dl, Isabel and Odemer, Richard and Becher, Matthias A. and Berg, Stefan and Otten, Christoph and Grimm, Volker and Groeneveld, J{\"u}rgen},
  title     = {Simulation of Varroa mite control in honey bee colonies without synthetic acaricides: demonstration of Good Beekeeping Practice for Germany in the BEEHAVE model},
  series = {Ecology and evolution},
  volume    = {12},
  journal   = {Ecology and evolution},
  number    = {11},
  publisher = {John Wiley \& Sons, Inc.},
  issn      = {2045-7758},
  doi       = {10.1002/ece3.9456},
  pages     = {14},
  year      = {2022},
  abstract  = {The BEEHAVE model simulates the population dynamics and foraging activity of a single honey bee colony (Apis mellifera) in great detail. Although it still makes numerous simplifying assumptions, it appears to capture a wide range of empirical observations. It could, therefore, in principle, also be used as a tool in beekeeper education, as it allows the implementation and comparison of different management options. Here, we focus on treatments aimed at controlling the mite Varroa destructor. However, since BEEHAVE was developed in the UK, mite treatment includes the use of a synthetic acaricide, which is not part of Good Beekeeping Practice in Germany. A practice that consists of drone brood removal from April to June, treatment with formic acid in August/September, and treatment with oxalic acid in November/December. We implemented these measures, focusing on the timing, frequency, and spacing between drone brood removals. The effect of drone brood removal and acid treatment, individually or in combination, on a mite-infested colony was examined. We quantify the efficacy of Varroa mite control as the reduction of mites in treated bee colonies compared to untreated bee colonies. We found that drone brood removal was very effective, reducing mites by 90\% at the end of the first simulation year after the introduction of mites. This value was significantly higher than the 50-67\% reduction expected by bee experts and confirmed by empirical studies. However, literature reports varying percent reductions in mite numbers from 10 to 85\% after drone brood removal. The discrepancy between model results, empirical data, and expert estimates indicate that these three sources should be reviewed and refined, as all are based on simplifying assumptions. These results and the adaptation of BEEHAVE to the Good Beekeeping Practice are a decisive step forward for the future use of BEEHAVE in beekeeper education in Germany and anywhere where organic acids and drone brood removal are utilized.},
  language  = {en}
}
@article{DreymannSabrowskiDansoetal.2022,
  author    = {Dreymann, Nico and Sabrowski, Wiebke and Danso, Jennifer and Menger, Marcus},
  title     = {Aptamer-based sandwich assay formats for detection and discrimination of human high- and low-molecular-weight uPA for cancer prognosis and diagnosis},
  series = {Cancers / Molecular Diversity Preservation International (MDPI)},
  volume    = {14},
  journal   = {Cancers / Molecular Diversity Preservation International (MDPI)},
  number    = {21},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2072-6694},
  doi       = {10.3390/cancers14215222},
  pages     = {17},
  year      = {2022},
  abstract  = {Simple Summary Urokinase-type plasminogen activator (urokinase, uPA) is a widely discussed biomarker for cancer prognosis and diagnosis. The gold standard for the determination of protein biomarkers in physiological samples is the enzyme-linked immunosorbent assay (ELISA). Here, antibodies are used to detect the specific protein. In our study, recently published urokinase aptamers were tested for their use in a sandwich assay format as alternative specific recognition elements. Different aptamer combinations were used for the detection of uPA in a sandwich-assay format and a combination of aptamers and antibodies additionally allowed the differentiation of human high and low molecular weight- (HMW- and LMW-) uPA. Hence, uPA aptamers offer a valuable alternative as specific recognition elements for analytical purposes. Since aptamers are easy to synthesize and modify, they can be used as a cost-effective alternative in sandwich assay formats for the detection of uPA in physiological samples. Abstract Urokinase-type plasminogen activator (urokinase, uPA) is a frequently discussed biomarker for prognosis, diagnosis, and recurrence of cancer. In a previous study, we developed ssDNA aptamers that bind to different forms of human urokinase, which are therefore assumed to have different binding regions. In this study, we demonstrate the development of aptamer-based sandwich assays that use different combinations of these aptamers to detect high molecular weight- (HMW-) uPA in a micro titer plate format. By combining aptamers and antibodies, it was possible to distinguish between HMW-uPA and low molecular weight- (LMW-) uPA. For the best performing aptamer combination, we calculated the limit of detection (LOD) and limit of quantification (LOQ) in spiked buffer and urine samples with an LOD up to 50 ng/mL and 138 ng/mL, respectively. To show the specificity and sequence dependence of the reporter aptamer uPAapt-02-FR, we have identified key nucleotides within the sequence that are important for specific folding and binding to uPA using a fluorescent dye-linked aptamer assay (FLAA). Since uPA is a much-discussed marker for prognosis and diagnosis in various types of cancers, these aptamers and their use in a micro titer plate assay format represent a novel, promising tool for the detection of uPA and for possible diagnostic applications.},
  language  = {en}
}
@article{KraemerHellmannAnvarietal.2022,
  author    = {Kr{\"a}mer, Kai Hauke and Hellmann, Frank and Anvari, Mehrnaz and Kurths, J{\"u}rgen and Marwan, Norbert},
  title     = {Spike spectra for recurrences},
  series = {Entropy : an international and interdisciplinary journal of entropy and information studies},
  volume    = {24},
  journal   = {Entropy : an international and interdisciplinary journal of entropy and information studies},
  number    = {11},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {1099-4300},
  doi       = {10.3390/e24111689},
  pages     = {18},
  year      = {2022},
  abstract  = {In recurrence analysis, the tau-recurrence rate encodes the periods of the cycles of the underlying high-dimensional time series. It, thus, plays a similar role to the autocorrelation for scalar time-series in encoding temporal correlations. However, its Fourier decomposition does not have a clean interpretation. Thus, there is no satisfactory analogue to the power spectrum in recurrence analysis. We introduce a novel method to decompose the tau-recurrence rate using an over-complete basis of Dirac combs together with sparsity regularization. We show that this decomposition, the inter-spike spectrum, naturally provides an analogue to the power spectrum for recurrence analysis in the sense that it reveals the dominant periodicities of the underlying time series. We show that the inter-spike spectrum correctly identifies patterns and transitions in the underlying system in a wide variety of examples and is robust to measurement noise.},
  language  = {en}
}
@article{MardoukhiChechkinMetzler2020,
  author    = {Mardoukhi, Yousof and Chechkin, Aleksei and Metzler, Ralf},
  title     = {Spurious ergodicity breaking in normal and fractional Ornstein-Uhlenbeck process},
  series = {New Journal of Physics},
  volume    = {22},
  journal   = {New Journal of Physics},
  publisher = {IOP},
  address   = {London},
  issn      = {1367-2630},
  doi       = {10.1088/1367-2630/ab950b},
  pages     = {18},
  year      = {2020},
  abstract  = {The Ornstein-Uhlenbeck process is a stationary and ergodic Gaussian process, that is fully determined by its covariance function and mean. We show here that the generic definitions of the ensemble- and time-averaged mean squared displacements fail to capture these properties consistently, leading to a spurious ergodicity breaking. We propose to remedy this failure by redefining the mean squared displacements such that they reflect unambiguously the statistical properties of any stochastic process. In particular we study the effect of the initial condition in the Ornstein-Uhlenbeck process and its fractional extension. For the fractional Ornstein-Uhlenbeck process representing typical experimental situations in crowded environments such as living biological cells, we show that the stationarity of the process delicately depends on the initial condition.},
  language  = {en}
}
@article{KayhanMatthesMarriottHaresignetal.2022,
  author    = {Kayhan, Ezgi and Matthes, Daniel and Marriott Haresign, Ira and B{\´a}nki, Anna and Michel, Christine and Langeloh, Miriam and Wass, Sam and H{\"o}hl, Stefanie},
  title     = {DEEP: A dual EEG pipeline for developmental hyperscanning studies},
  series = {Developmental Cognitive Neuroscience},
  volume    = {54},
  journal   = {Developmental Cognitive Neuroscience},
  publisher = {Elsevier},
  address   = {Amsterdam, Niederlande},
  issn      = {1878-9307},
  doi       = {10.1016/j.dcn.2022.101104},
  pages     = {1 -- 11},
  year      = {2022},
  abstract  = {Cutting-edge hyperscanning methods led to a paradigm shift in social neuroscience. It allowed researchers to measure dynamic mutual alignment of neural processes between two or more individuals in naturalistic contexts. The ever-growing interest in hyperscanning research calls for the development of transparent and validated data analysis methods to further advance the field. We have developed and tested a dual electroencephalography (EEG) analysis pipeline, namely DEEP. Following the preprocessing of the data, DEEP allows users to calculate Phase Locking Values (PLVs) and cross-frequency PLVs as indices of inter-brain phase alignment of dyads as well as time-frequency responses and EEG power for each participant. The pipeline also includes scripts to control for spurious correlations. Our goal is to contribute to open and reproducible science practices by making DEEP publicly available together with an example mother-infant EEG hyperscanning dataset.},
  language  = {en}
}
@article{ApeltKochMichalowskietal.2023,
  author    = {Apelt, Maja and Koch, Annika and Michalowski, Ines and Molzberger, Kaspar and Schenk, Liane and Schmidt, Max Oliver},
  title     = {How organisations regulate Muslim body practices},
  series = {Comparative migration studies},
  volume    = {11},
  journal   = {Comparative migration studies},
  publisher = {European Research Centre on Migration and Ethnic Relations},
  address   = {Utrecht},
  issn      = {2214-594X},
  doi       = {10.1186/s40878-023-00355-y},
  pages     = {19},
  year      = {2023},
  abstract  = {In a comparison of three human service organisations in which the human body plays a key role, we examine how organisations regulate religious body practices. We concentrate on Muslim norms of dressing and undressing as a potential focal point of cultural and religious diversity. Inspired by Ray's (2019) idea of racialized organizations, we assume that state-run organizations in Germany are characterized by a strong commitment to religious tolerance and non-discrimination but also marked by anti- Muslim sentiment prevalent among the German population. Our study looks for mechanism that explain how Human Service Organizations accommodate Muslim body practices. It draws on qualitative empirical data collected in state-run hospitals, schools and swimming pools in Germany. Our analyses show that the organizations draw on formal and informal rules at the organizational level to accommodate Islam. We identify five general organizational mechanisms that may hinder Muslim accommodation in human service organizations. In particular, we see a risk of decoupling between the expectation of religious tolerance and processes that lead to informal discrimination, driven mainly by the difficulty of controlling group dynamics among users.},
  language  = {en}
}
@article{WilhelmiGrunwaldGimberetal.2020,
  author    = {Wilhelmi, Ilka and Grunwald, Stephan and Gimber, Niclas and Popp, Oliver and Dittmar, Gunnar and Arumughan, Anup and Wanker, Erich E. and Laeger, Thomas and Schmoranzer, Jan and Daumke, Oliver and Sch{\"u}rmann, Annette},
  title     = {The ARFRP1-dependent Golgi scaffolding protein GOPC is required for insulin secretion from pancreatic 13-cells},
  series = {Molecular metabolism},
  volume    = {45},
  journal   = {Molecular metabolism},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {2212-8778},
  doi       = {10.1016/j.molmet.2020.101151},
  pages     = {13},
  year      = {2020},
  abstract  = {Objective: Hormone secretion from metabolically active tissues, such as pancreatic islets, is governed by specific and highly regulated signaling pathways. Defects in insulin secretion are among the major causes of diabetes. The molecular mechanisms underlying regulated insulin secretion are, however, not yet completely understood. In this work, we studied the role of the GTPase ARFRP1 on insulin secretion from pancreatic 13-cells. <br /> Methods: A 13-cell-specific Arfrp1 knockout mouse was phenotypically characterized. Pulldown experiments and mass spectrometry analysis were employed to screen for new ARFRP1-interacting proteins. Co-immunoprecipitation assays as well as super-resolution microscopy were applied for validation. <br /> Results: The GTPase ARFRP1 interacts with the Golgi-associated PDZ and coiled-coil motif-containing protein (GOPC). Both proteins are co localized at the trans-Golgi network and regulate the first and second phase of insulin secretion by controlling the plasma membrane localization of the SNARE protein SNAP25. Downregulation of both GOPC and ARFRP1 in Min6 cells interferes with the plasma membrane localization of SNAP25 and enhances its degradation, thereby impairing glucose-stimulated insulin release from 13-cells. In turn, overexpression of SNAP25 as well as GOPC restores insulin secretion in islets from 13-cell-specific Arfrp1 knockout mice. <br /> Conclusion: Our results identify a hitherto unrecognized pathway required for insulin secretion at the level of trans-Golgi sorting. (c) 2020 The Authors. Published by Elsevier GmbH. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).},
  language  = {en}
}
@article{KobsEhlertLenkeitetal.2022,
  author    = {Kobs, Scarlett and Ehlert, Antje and Lenkeit, Jenny and Hartmann, Anne Therese and Sporer, Nadine and Knigge, Michel},
  title     = {The influence of individual and situational factors on teachers' justice ratings of classroom interactions},
  series = {Frontiers in psychology},
  volume    = {13},
  journal   = {Frontiers in psychology},
  publisher = {Frontiers Media},
  address   = {Lausanne},
  issn      = {1664-1078},
  doi       = {10.3389/fpsyg.2022.789110},
  pages     = {18},
  year      = {2022},
  abstract  = {Teachers, as role models, are crucial in promoting inclusion in society through their actions. Being perceived as fair by their students is linked to students' feelings of belonging in school. In addition, their decisions of resource allocations also affect students' academic success. Both aspects underpin the importance of teachers' views on justice. This article aims to investigate what teachers consider to be just and how teacher characteristics and situational factors affect justice ratings of hypothetical student-teacher-interactions. In an experimental design, we randomly varied the description of the interacting student in text vignettes regarding his/her special educational need (SEN) (situational factor). We also collected data on teachers' attitudes toward inclusion and experiences with persons with disabilities (individual factors). A sample of in-service teachers in Germany (N = 2,254) rated randomized versions of two text vignettes. To also consider the effect of professional status, a sample of pre-service teachers (N = 275) did the same. Linear mixed effect models point to a negative effect of the SEN on justice ratings, meaning situations in which the interacting student is described with a SEN were rated less just compared to the control condition. As the interacting student in the situations was treated worse than the rest, this was indicative for the application of the need principle. Teachers with more positive attitudes toward inclusion rated the vignettes as significantly less just. Professional status also had a negative effect on justice ratings, with in-service teachers rating the interactions significantly lower than the pre-service teachers. Our results suggest that the teachers applied the principle of need in their ratings. Implications for inclusive teaching practices and future research are discussed further.},
  language  = {en}
}
@inproceedings{PepplerFeisstSchneideretal.2023,
  author    = {Peppler, Lisa and Feißt, Martin and Schneider, Anna and Apelt, Maja and Schenk, Liane},
  title     = {Beyond one-sided expectations of integration},
  series = {European journal of public health},
  volume    = {33},
  booktitle = {European journal of public health},
  number    = {Supplement 2},
  publisher = {Oxford University Press},
  address   = {London},
  issn      = {1101-1262},
  doi       = {10.1093/eurpub/ckad160.1484},
  pages     = {1},
  year      = {2023},
  abstract  = {Background: Like most countries, Germany is currently recruiting international nurses due to staff shortages. While these are mostly academic, the academisation of nursing in Germany has only just begun. This allows for a broader look at the participation of migrant nurses: How do care teams deal with the fact that immigrant colleagues are theoretically more highly qualified than long-established colleagues? Methods: Case studies were conducted in four inpatient care teams of two hospitals in 2022. Qualitative data include 26 observation protocols, 4 group discussions and 17 guided interviews. These were analysed using the documentary method and validated intersubjectively. Results: Due to current academisation efforts in Germany and the immigration of academised nursing staff from abroad, the areas of activity and responsibility of nursing in Germany are under negotiating pressure. This concerns basic care for example, which in Germany is provided by skilled workers, but in other countries is mostly provided by assistants or relatives. The question of who should provide basic care, whether all nurses or only nursing assistants, documents the struggle between an established and a new understanding of care. In this context, the knowledge and skills of migrant and academicised care workers become a crucial aspect in the struggle for a new professional identity for care in Germany. Conclusions: The specific situation in Germany makes it possible to show the potential for change that international care migration can constitute for destination countries. The far-reaching process of change of German nursing is given a further dimension not only by its academization, but by the immigration of international and academically trained nursing staff, where inclusive or exclusive effects can already be observed. Key messages: The increasing proportion of migrant nurses accelerates the current discussion on nursing in Germany. Conflict areas show up in everyday work of care teams and must be addressed there.},
  language  = {en}
}
@article{MonteroCrucifixCoupletetal.2022,
  author    = {Montero, Marina Mart{\´i}nez and Crucifix, Michel and Couplet, Victor and Brede, Nuria and Botta, Nicola},
  title     = {SURFER v2.0: a flexible and simple model linking anthropogenic CO2 emissions and solar radiation modification to ocean acidification and sea level rise},
  series = {Geoscientific model development : an interactive open access journal of the European Geosciences Union},
  volume    = {15},
  journal   = {Geoscientific model development : an interactive open access journal of the European Geosciences Union},
  number    = {21},
  publisher = {Copernicus},
  address   = {Katlenburg-Lindau},
  issn      = {1991-959X},
  doi       = {10.5194/gmd-15-8059-2022},
  pages     = {8059 -- 8084},
  year      = {2022},
  abstract  = {We present SURFER, a novel reduced model for estimating the impact of CO2 emissions and solar radiation modification options on sea level rise and ocean acidification over timescales of several thousands of years. SURFER has been designed for the analysis of CO2 emission and solar radiation modification policies, for supporting the computation of optimal (CO2 emission and solar radiation modification) policies and for the study of commitment and responsibility under uncertainty. The model is based on a combination of conservation laws for the masses of atmospheric and oceanic carbon and for the oceanic temperature anomalies, and of adhoc parameterisations for the different sea level rise contributors: ice sheets, glaciers and ocean thermal expansion. It consists of 9 loosely coupled ordinary differential equations, is understandable, fast and easy to modify and calibrate. It reproduces the results of more sophisticated, high-dimensional earth system models on timescales up to millennia.},
  language  = {en}
}
@article{GuillenLindgrenMuffetal.2023,
  author    = {Guillen, Rafael Arce and Lindgren, Finn and Muff, Stefanie and Glass, Thomas W. and Breed, Greg A. and Schl{\"a}gel, Ulrike},
  title     = {Accounting for unobserved spatial variation in step selection analyses of animal movement via spatial random effects},
  series = {Methods in ecology and evolution : MEE},
  volume    = {14},
  journal   = {Methods in ecology and evolution : MEE},
  number    = {10},
  publisher = {Wiley},
  address   = {Oxford},
  issn      = {2041-210X},
  doi       = {10.1111/2041-210X.14208},
  pages     = {2639 -- 2653},
  year      = {2023},
  abstract  = {Step selection analysis (SSA) is a common framework for understanding animal movement and resource selection using telemetry data. Such data are, however, inherently autocorrelated in space, a complication that could impact SSA-based inference if left unaddressed. Accounting for spatial correlation is standard statistical practice when analysing spatial data, and its importance is increasingly recognized in ecological models (e.g. species distribution models). Nonetheless, no framework yet exists to account for such correlation when analysing animal movement using SSA. Here, we extend the popular method integrated step selection analysis (iSSA) by including a Gaussian field (GF) in the linear predictor to account for spatial correlation. For this, we use the Bayesian framework R-INLA and the stochastic partial differential equations (SPDE) technique. We show through a simulation study that our method provides accurate fixed effects estimates, quantifies their uncertainty well and improves the predictions. In addition, we demonstrate the practical utility of our method by applying it to three wolverine (Gulo gulo) tracks. Our method solves the problems of assuming spatially independent residuals in the SSA framework. In addition, it offers new possibilities for making long-term predictions of habitat usage.},
  language  = {en}
}
@article{JiangSongBaueretal.2022,
  author    = {Jiang, Feng and Song, Junwei and Bauer, Jonas and Gao, Linyu and Vallon, Magdalena and Gebhardt, Reiner and Leisner, Thomas and Norra, Stefan and Saathoff, Harald},
  title     = {Chromophores and chemical composition of brown carbon characterized at anurban kerbside by excitation-emission spectroscopy and mass spectrometry},
  series = {Atmospheric chemistry and physics},
  volume    = {22},
  journal   = {Atmospheric chemistry and physics},
  number    = {22},
  publisher = {EGU},
  address   = {Katlenburg-Lindau},
  issn      = {1680-7316},
  doi       = {10.5194/acp-22-14971-2022},
  pages     = {14971 -- 14986},
  year      = {2022},
  abstract  = {The optical properties, chemical composition, and potential chromophores of brown carbon (BrC) aerosol particles were studied during typical summertime and wintertime at a kerbside in downtown Karl-sruhe, a city in central Europe. The average absorption coefficient and mass absorption efficiency at 365 nm (Abs(365) and MAE(365)) of methanol-soluble BrC (MS-BrC) were lower in the summer period (1.6 +/- 0.5 Mm(-1), 0.5 +/- 0.2 m(2) g(-1)) than in the winter period (2.8 +/- 1.9 Mm(-1), 1.1 +/- 0.3 m(2) g(-1)). Using a parallel factor (PARAFAC) analysis to identify chromophores, two different groups of highly oxygenated humic-like substances (HO-HULIS) dominated in summer and contributed 96 +/- 6 \% of the total fluorescence intensity. In contrast, less-oxygenated HULIS (LO-HULIS) dominated the total fluorescence intensity in winter with 57 +/- 12 \%, followed by HO-HULIS with 31 +/- 18 \%. Positive matrix factorization (PMF) analysis of organic compounds detected in real time by an online aerosol mass spectrometer (AMS) led to five characteristic organic compound classes. The statistical analysis of PARAFAC components and PMF factors showed that LO-HULIS chromophores were most likely emitted from biomass burning in winter. HO-HULIS chromophores could be low-volatility oxy-genated organic aerosol from regional transport and oxidation of biogenic volatile organic compounds (VOCs) in summer. Five nitro-aromatic compounds (NACs) were identified by a chemical ionization mass spectrometer (C7H7O3N, C7H7O4N, C6H5O5N, C6H5O4N, and C6H5O3N), which contributed 0.03 +/- 0.01 \% to the total organic mass but can explain 0.3 +/- 0.1 \% of the total absorption of MS-BrC at 365 nm in winter. Furthermore, we identified 316 potential brown carbon molecules which accounted for 2.5 +/- 0.6 \% of the organic aerosol mass. Using an average mass absorption efficiency (MAE(365)) of 9.5 m(2)g(-1) for these compounds, we can es-timate their mean light absorption to be 1.2 +/- 0.2 Mm(-1), accounting for 32 +/- 15 \% of the total absorption of MS-BrC at 365 nm. This indicates that a small fraction of brown carbon molecules dominates the overall ab-sorption. The potential BrC molecules assigned to the LO-HULIS component had a higher average molecular weight (265 +/- 2 Da) and more nitrogen-containing molecules (62 +/- 1 \%) than the molecules assigned to the HOHULIS components. Our analysis shows that the LO-HULIS, with a high contribution of nitrogen-containing molecules originating from biomass burning, dominates aerosol fluorescence in winter, and HO-HULIS, with fewer nitrogen-containing molecules as low-volatility oxygenated organic aerosol from regional transport and oxidation of biogenic volatile organic compounds (VOC), dominates in summer.},
  language  = {en}
}
@misc{OtienoMoongaNidensetal.2022,
  author    = {Otieno, Melvine Anyango and Moonga, Given and Nidens, Nathalie and Magero, Norah Vivian and Jung, Laura},
  title     = {Adapting to a changing environment: inspiration for planetary health from east African communities},
  series = {The lancet. Planetary health},
  volume    = {6},
  journal   = {The lancet. Planetary health},
  number    = {10},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {2542-5196},
  doi       = {10.1016/S2542-5196(22)00193-0},
  pages     = {E775 -- E776},
  year      = {2022},
  language  = {en}
}
@article{HeinenHeisselHeinzeletal.2023,
  author    = {Heinen, Darlene and Heissel, Andreas and Heinzel, Stephan and Fydrich, Thomas and Str{\"o}hle, Andreas and Rapp, Michael A. and Vogel, Heike},
  title     = {Effect of acute and long-term exercise on leptin levels in depressed outpatients},
  series = {BMC public health},
  volume    = {23},
  journal   = {BMC public health},
  publisher = {BioMed Central},
  address   = {London},
  issn      = {1471-2458},
  doi       = {10.1186/s12889-023-17362-4},
  pages     = {11},
  year      = {2023},
  abstract  = {Background Depression is a leading cause of disability worldwide and a significant contributor to the global burden of disease. Altered leptin levels are known to be associated with depressive symptoms, however discrepancies in the results of increased or decreased levels exist. Due to various limitations associated with commonly used antidepressant drugs, alternatives such as exercise therapy are gaining more importance. Therefore, the current study investigates whether depressed patients have higher leptin levels compared to healthy controls and if exercise is efficient to reduce these levels. Methods Leptin levels of 105 participants with major depressive disorder (MDD; 45.7\% female, age mean ± SEM: 39.1 ± 1.0) and 34 healthy controls (HC; 61.8\% female, age mean ± SEM: 36.0 ± 2.0) were measured before and after a bicycle ergometer test. Additionally, the MDD group was separated into three groups: two endurance exercise intervention groups (EX) differing in their intensities, and a waiting list control group (WL). Leptin levels were measured pre and post a 12-week exercise intervention or the waiting period. Results Baseline data showed no significant differences in leptin levels between the MDD and HC groups. As expected, correlation analyses displayed significant relations between leptin levels and body weight (HC: r = 0.474, p = 0.005; MDD: r = 0.198, p = 0.043) and even more with body fat content (HC: r = 0.755, p \&lt; 0.001; MDD: r = 0.675, p \&lt; 0.001). The acute effect of the bicycle ergometer test and the 12-week training intervention showed no significant changes in circulating leptin levels. Conclusion Leptin levels were not altered in patients with major depression compared to healthy controls and exercise, both the acute response and after 12 weeks of endurance training, had no effect on the change in leptin levels. Trial registration The study was registered at the German register for clinical studies (DRKS) and the International Clinical Trials Registry Platform of the World Health Organization https://trialsearch.who.int/Trial2.aspx?TrialID=DRKS00008869 on 28/07/2015.},
  language  = {en}
}
@article{BaritelloSteinWolffetal.2023,
  author    = {Baritello, Omar and Stein, Hanna and Wolff, Lara Luisa and Hamann, Maria and V{\"o}ller, Heinz and Salzwedel, Annett},
  title     = {Effect of multicomponent rehabilitation on independence and functioning in elderly patients with common age-associated diseases},
  series = {BMJ open},
  volume    = {13},
  journal   = {BMJ open},
  number    = {5},
  publisher = {BMJ Publishing Group},
  address   = {London},
  issn      = {2044-6055},
  doi       = {10.1136/bmjopen-2022-068722},
  pages     = {7},
  year      = {2023},
  abstract  = {Introduction Elderly patients after hospitalisation for acute events on account of age-related diseases (eg, joint or heart valve replacement surgery) are often characterised by a remarkably reduced functional health. Multicomponent rehabilitation (MR) is considered an appropriate approach to restore the functioning of these patients. However, its efficacy in improving functioning-related outcomes such as care dependency, activities of daily living (ADL), physical function and health-related quality of life (HRQL) remains unclarified. We outline the research framework of a scoping review designed to map the available evidence of the effects of MR on the independence and functional capacity of elderly patients hospitalised for age-related diseases in four main medical specialties beyond geriatrics. Methods and analysis The biomedical databases (PubMed, Cochrane Library, ICTRP Search Platform, ClinicalTrials) and additionally Google Scholar will be systematically searched for studies comparing centre-based MR with usual care in patients ≥75 years of age, hospitalised for common acute events due to age-related diseases (eg, joint replacement, stroke) in one of the specialties of orthopaedics, oncology, cardiology or neurology. MR is defined as exercise training and at least one additional component (eg, nutritional counselling), starting within 3 months after hospital discharge. Randomised controlled trials as well as prospective and retrospective controlled cohort studies will be included from inception and without language restriction. Studies investigating patients \&lt;75 years, other specialties (eg, geriatrics), rehabilitation definition or differently designed will be excluded. Care dependency after at least a 6-month follow-up is set as the primary outcome. Physical function, HRQL, ADL, rehospitalisation and mortality will be additionally considered. Data for each outcome will be summarised, stratified by specialty, study design and type of assessment. Furthermore, quality assessment of the included studies will be performed. Ethics and dissemination Ethical approval is not required. Findings will be published in a peer-reviewed journal and presented at national and/or international congresses.},
  language  = {en}
}