@article{GrasslRitterSchulz2022, author = {Grassl, Sandra and Ritter, Christoph and Schulz, Alexander}, title = {The nature of the Ny-Alesund wind field analysed by high-resolution windlidar data}, series = {Remote sensing}, volume = {14}, journal = {Remote sensing}, number = {15}, publisher = {MDPI}, address = {Basel}, issn = {2072-4292}, doi = {10.3390/rs14153771}, pages = {24}, year = {2022}, abstract = {In this work we present windlidar data for the research village Ny-Alesund located on Svalbard in the European Arctic (78.923 degrees N, 11.928 degrees F) from 2013 to 2021. The data have a resolution of 50 m and 10 min with an overlapping height of about 150 m. The maximum range depends on the meteorologic situation. Up to 1000 m altitude the data availability is better than 71\%. We found that the highest wind speeds occur in November and December, the lowest ones in June and July, up to 500 m altitude the wind is channelled strongly in ESE to NW direction parallel to the fjord axis and the synoptic conditions above 1000 m altitude already dominate. While the fraction of windy days (v > 10 m/s) varies significantly from month to month, there is no overall trend of the wind visible in our data set. We define gusts and jets by the requirement of wind maxima v > 2 m/s above and below a wind maximum. In total, more than 24,000 of these events were identified (corresponding to 6\% of the time), of which 223 lasted for at least 100 min ("Long Jets"). All of these events are fairly equally distributed over the months relatively to the available data. Further, gusts and jets follow different distributions (in terms of altitude or depths) and occur more frequently for synoptic flow from roughly a southerly direction. Jets do not show a clear correlation between occurrence and synoptic flow. Gusts and jets are not related to cloud cover. We conclude that the atmosphere from 400 m to 1000 m above Ny-Alesund is dominated by a turbulent wind shear zone, which connects the micrometeorology in the atmospheric boundary layer (ABL) with the synoptic flow.}, language = {en} } @article{BlockGuenterDuarteRodriguesetal.2021, author = {Block, Inga and G{\"u}nter, Christina and Duarte Rodrigues, Alysson and Paasch, Silvia and Hesemann, Peter and Taubert, Andreas}, title = {Carbon adsorbents from spent coffee for removal of methylene blue and methyl orange from water}, series = {Materials / Molecular Diversity Preservation International}, volume = {14}, journal = {Materials / Molecular Diversity Preservation International}, number = {14}, publisher = {Molecular Diversity Preservation International}, address = {Basel}, issn = {1996-1944}, doi = {10.3390/ma14143996}, pages = {18}, year = {2021}, abstract = {Activated carbons (ACs) were prepared from dried spent coffee (SCD), a biological waste product, to produce adsorbents for methylene blue (MB) and methyl orange (MO) from aqueous solution. Pre-pyrolysis activation of SCD was achieved via treatment of the SCD with aqueous sodium hydroxide solutions at 90 °C. Pyrolysis of the pretreated SCD at 500 °C for 1 h produced powders with typical characteristics of AC suitable and effective for dye adsorption. As an alternative to the rather harsh base treatment, calcium carbonate powder, a very common and abundant resource, was also studied as an activator. Mixtures of SCD and CaCO3 (1:1 w/w) yielded effective ACs for MO and MB removal upon pyrolysis needing only small amounts of AC to clear the solutions. A selectivity of the adsorption process toward anionic (MO) or cationic (MB) dyes was not observed.}, language = {en} } @article{RuszkiewiczPapatheodorouJaecketal.2023, author = {Ruszkiewicz, Joanna and Papatheodorou, Ylea and J{\"a}ck, Nathalie and Melzig, Jasmin and Eble, Franziska and Pirker, Annika and Thomann, Marius and Haberer, Andreas and Rothmiller, Simone and B{\"u}rkle, Alexander and Mangerich, Aswin}, title = {NAD+ Acts as a protective factor in cellular stress response to DNA alkylating agents}, series = {Cells : open access journal}, volume = {12}, journal = {Cells : open access journal}, number = {19}, publisher = {MDPI}, address = {Basel}, issn = {2073-4409}, doi = {10.3390/cells12192396}, pages = {22}, year = {2023}, abstract = {Sulfur mustard (SM) and its derivatives are potent genotoxic agents, which have been shown to trigger the activation of poly (ADP-ribose) polymerases (PARPs) and the depletion of their substrate, nicotinamide adenine dinucleotide (NAD+). NAD+ is an essential molecule involved in numerous cellular pathways, including genome integrity and DNA repair, and thus, NAD+ supplementation might be beneficial for mitigating mustard-induced (geno)toxicity. In this study, the role of NAD+ depletion and elevation in the genotoxic stress response to SM derivatives, i.e., the monofunctional agent 2-chloroethyl-ethyl sulfide (CEES) and the crosslinking agent mechlorethamine (HN2), was investigated with the use of NAD+ booster nicotinamide riboside (NR) and NAD+ synthesis inhibitor FK866. The effects were analyzed in immortalized human keratinocytes (HaCaT) or monocyte-like cell line THP-1. In HaCaT cells, NR supplementation, increased NAD+ levels, and elevated PAR response, however, did not affect ATP levels or DNA damage repair, nor did it attenuate long- and short-term cytotoxicities. On the other hand, the depletion of cellular NAD+ via FK866 sensitized HaCaT cells to genotoxic stress, particularly CEES exposure, whereas NR supplementation, by increasing cellular NAD+ levels, rescued the sensitizing FK866 effect. Intriguingly, in THP-1 cells, the NR-induced elevation of cellular NAD+ levels did attenuate toxicity of the mustard compounds, especially upon CEES exposure. Together, our results reveal that NAD+ is an important molecule in the pathomechanism of SM derivatives, exhibiting compound-specificity. Moreover, the cell line-dependent protective effects of NR are indicative of system-specificity of the application of this NAD+ booster.}, language = {en} } @article{LachmairFischerGerjets2022, author = {Lachmair, Martin and Fischer, Martin H. and Gerjets, Peter}, title = {Action-control mappings of interfaces in virtual reality: a study of embodied interaction}, series = {Frontiers in virtual reality}, volume = {3}, journal = {Frontiers in virtual reality}, publisher = {Frontiers Media}, address = {Lausanne}, issn = {2673-4192}, doi = {10.3389/frvir.2022.976849}, pages = {11}, year = {2022}, abstract = {The development of interface technologies is driven by the goal of making interaction more positive through natural action-control mappings. In Virtual Reality (VR), the entire body is potentially involved for interaction, using such mappings with a maximum of degrees of freedom. The downside is the increase in interaction complexity, which can dramatically influence interface design. A cognitive perspective on detailed aspects of interaction patterns is lacking in common interface design guidelines, although it can be helpful to make this complexity controllable and, thus, make interaction behavior predictable. In the present study, the distinction between grounding, embodiment, and situatedness (the GES framework) is applied to organize aspects of interactions and to compare them with each other. In two experiments, zooming into or out of emotional pictures through changes of arm span was examined in VR. There are qualitatively different aspects during such an interaction: i) perceptual aspects caused by zooming are fundamental for human behavior (Grounding: closer objects appear bigger) and ii) aspects of gestures correspond to the physical characteristics of the agents (Embodiment: little distance of hands signals little or, in contrast, "creating more detail"). The GES-framework sets aspects of Grounding against aspects of Embodiment, thus allowing to predict human behavior regarding these qualitatively different aspects. For the zooming procedure, the study shows that Grounding can overrule Embodiment in interaction design. Thus, we propose GES as a cognitive framework that can help to inform interaction guidelines for user interface design in VR.}, language = {en} } @article{SieberWilkeAppeltetal.2022, author = {Sieber, Melanie J. and Wilke, Max and Appelt, Oona and Oelze, Marcus and Koch-M{\"u}ller, Monika}, title = {Melting relations of Ca-Mg carbonates and trace element signature of carbonate melts up to 9 GPa - a proxy for melting of carbonated mantle lithologies}, series = {European journal of mineralogy}, volume = {34}, journal = {European journal of mineralogy}, number = {5}, publisher = {Copernicus}, address = {G{\"o}ttingen}, issn = {0935-1221}, doi = {10.5194/ejm-34-411-2022}, pages = {411 -- 424}, year = {2022}, abstract = {The most profound consequences of the presence of Ca-Mg carbonates (CaCO3-MgCO3) in the Earth's upper mantle may be to lower the melting temperatures of the mantle and control the melt composition. Low-degree partial melting of a carbonate-bearing mantle produces CO2-rich, silica-poor melts compositionally imposed by the melting relations of carbonates. Thus, understanding the melting relations in the CaCO3-MgCO3 system facilitates the interpretation of natural carbonate-bearing silicate systems. We report the melting relations of the CaCO3-MgCO3 system and the partition coefficient of trace elements between carbonates and carbonate melt from experiments at high pressure (6 and 9 GPa) and temperature (1300-1800 degrees C) using a rocking multi-anvil press. In the absence of water, Ca-Mg carbonates are stable along geothermal gradients typical of subducting slabs. Ca-Mg carbonates ( similar to Mg0.1-0.9Ca0.9-0.1CO3) partially melt beneath mid-ocean ridges and in plume settings. Ca-Mg carbonates melt incongruently, forming periclase crystals and carbonate melt between 4 and 9 GPa. Furthermore, we show that the rare earth element (REE) signature of Group-I kimberlites, namely strong REE fractionation and depletion of heavy REE relative to the primitive mantle, is resembled by carbonate melt in equilibrium with Ca-bearing magnesite and periclase at 6 and 9 GPa. This suggests that the dolomite-magnesite join of the CaCO3-MgCO3 system might be useful to approximate the REE signature of carbonate-rich melts parental to kimberlites.}, language = {en} } @article{JonasSchwerbelZellneretal.2022, author = {Jonas, Wenke and Schwerbel, Kristin and Zellner, Lisa and J{\"a}hnert, Markus and Gottmann, Pascal and Sch{\"u}rmann, Annette}, title = {Alterations of lipid profile in livers with impaired lipophagy}, series = {International journal of molecular sciences}, volume = {23}, journal = {International journal of molecular sciences}, number = {19}, publisher = {MDPI}, address = {Basel}, issn = {1422-0067}, doi = {10.3390/ijms231911863}, pages = {12}, year = {2022}, abstract = {Non-alcoholic fatty liver disease (NAFLD) is characterized by excessive lipid accumulation in the liver. Various mechanisms such as an increased uptake in fatty acids or de novo synthesis contribute to the development of steatosis and progression to more severe stages. Furthermore, it has been shown that impaired lipophagy, the degradation of lipids by autophagic processes, contributes to NAFLD. Through an unbiased lipidome analysis of mouse livers in a genetic model of impaired lipophagy, we aimed to determine the resulting alterations in the lipidome. Observed changes overlap with those of the human disease. Overall, the entire lipid content and in particular the triacylglycerol concentration increased under conditions of impaired lipophagy. In addition, we detected a reduction in long-chain polyunsaturated fatty acids (PUFAs) and an increased ratio of n-6 PUFAs to n-3 PUFAs, which was due to the depletion of n-3 PUFAs. Although the abundance of major phospholipid classes was reduced, the ratio of phosphatidylcholines to phosphatidylethanolamines was not affected. In conclusion, this study demonstrates that impaired lipophagy contributes to the pathology of NAFLD and is associated with an altered lipid profile. However, the lipid pattern does not appear to be specific for lipophagic alterations, as it resembles mainly that described in relation to fatty liver disease.}, language = {en} } @article{BillingThonickeSakschewskietal.2022, author = {Billing, Maik and Thonicke, Kirsten and Sakschewski, Boris and von Bloh, Werner and Walz, Ariane}, title = {Future tree survival in European forests depends on understorey tree diversity}, series = {Scientific reports}, volume = {12}, journal = {Scientific reports}, number = {1}, publisher = {Springer Nature}, address = {Berlin}, issn = {2045-2322}, doi = {10.1038/s41598-022-25319-7}, pages = {12}, year = {2022}, abstract = {Climate change heavily threatens forest ecosystems worldwide and there is urgent need to understand what controls tree survival and forests stability. There is evidence that biodiversity can enhance ecosystem stability (Loreau and de Mazancourt in Ecol Lett 16:106-115, 2013; McCann in Nature 405:228-233, 2000), however it remains largely unclear whether this also holds for climate change and what aspects of biodiversity might be most important. Here we apply machine learning to outputs of a flexible-trait Dynamic Global Vegetation Model to unravel the effects of enhanced functional tree trait diversity and its sub-components on climate-change resistance of temperate forests (http://www.pik-potsdam.de/similar to billing/video/Forest_Resistance_LPJmLFIT.mp4). We find that functional tree trait diversity enhances forest resistance. We explain this with 1. stronger complementarity effects (similar to 25\% importance) especially improving the survival of trees in the understorey of up to +16.8\% (+/- 1.6\%) and 2. environmental and competitive filtering of trees better adapted to future climate (40-87\% importance). We conclude that forests containing functionally diverse trees better resist and adapt to future conditions. In this context, we especially highlight the role of functionally diverse understorey trees as they provide the fundament for better survival of young trees and filtering of resistant tree individuals in the future.}, language = {en} } @article{KuehneFauthAyBrysonetal.2021, author = {K{\"u}hne, Franziska and Fauth, Henriette and Ay-Bryson, Destina Sevde and Visser, Leonie N.C. and Weck, Florian}, title = {Communicating the diagnosis of cancer or depression}, series = {Cancer medicine}, volume = {10}, journal = {Cancer medicine}, number = {24}, publisher = {Wiley}, address = {Hoboken, New Jersey, USA}, issn = {2045-7634}, doi = {10.1002/cam4.4396}, pages = {9012 -- 9021}, year = {2021}, abstract = {Background Communicating a diagnosis is highly important, yet complex, especially in the context of cancer and mental disorders. The aim was to explore the communication style of an oncologist vs. psychotherapist in an online study. Methods Patients (N = 136: 65 cancer, 71 depression) were randomly assigned to watch a standardized video vignette with one of two communication styles (empathic vs. unempathic). Outcome measures of affectivity, information recall, communication skills, empathy and trust were applied. Results Regardless of diagnosis, empathic communication was associated with the perception of a significantly more empathic (p < 0.001, η2partial = 0.08) and trustworthy practitioner (p = 0.014, η2partial = 0.04) with better communication skills (p = 0.013, η2partial = 0.05). Cancer patients reported a larger decrease in positive affect (p < 0.001, η2partial = 0.15) and a larger increase in negative affect (p < 0.001, η2partial = 0.14) from pre- to post-video than depressive patients. Highly relevant information was recalled better in both groups (p < 0.001, d = 0.61-1.06). Conclusions The results highlight the importance of empathy while communicating both a diagnosis of cancer and a mental disorder. Further research should focus on the communication of a mental disorder in association with cancer.}, language = {en} } @article{MontiRautenstrauchGhanbarietal.2022, author = {Monti, Remo and Rautenstrauch, Pia and Ghanbari, Mahsa and James, Alva Rani and Kirchler, Matthias and Ohler, Uwe and Konigorski, Stefan and Lippert, Christoph}, title = {Identifying interpretable gene-biomarker associations with functionally informed kernel-based tests in 190,000 exomes}, series = {Nature Communications}, volume = {13}, journal = {Nature Communications}, publisher = {Nature Publishing Group UK}, address = {London}, issn = {2041-1723}, doi = {10.1038/s41467-022-32864-2}, pages = {16}, year = {2022}, abstract = {Here we present an exome-wide rare genetic variant association study for 30 blood biomarkers in 191,971 individuals in the UK Biobank. We compare gene- based association tests for separate functional variant categories to increase interpretability and identify 193 significant gene-biomarker associations. Genes associated with biomarkers were ~ 4.5-fold enriched for conferring Mendelian disorders. In addition to performing weighted gene-based variant collapsing tests, we design and apply variant-category-specific kernel-based tests that integrate quantitative functional variant effect predictions for mis- sense variants, splicing and the binding of RNA-binding proteins. For these tests, we present a computationally efficient combination of the likelihood- ratio and score tests that found 36\% more associations than the score test alone while also controlling the type-1 error. Kernel-based tests identified 13\% more associations than their gene-based collapsing counterparts and had advantages in the presence of gain of function missense variants. We introduce local collapsing by amino acid position for missense variants and use it to interpret associations and identify potential novel gain of function variants in PIEZO1. Our results show the benefits of investigating different functional mechanisms when performing rare-variant association tests, and demonstrate pervasive rare-variant contribution to biomarker variability.}, language = {en} } @article{KaapDeederSanchezFernandezJohannessenetal.2022, author = {Kaap-Deeder, Jolene van der and S{\´a}nchez Fern{\`a}ndez, Alba Cristina and Johannessen, Maria Regine Aasland and Stenseng, Frode and Saksvik-Lehouillier, Ingvild and Heißel, Andreas}, title = {The validation of the Norwegian basic psychological need satisfaction and frustration scale: a stratified sampling procedure}, series = {Frontiers in psychology}, volume = {13}, journal = {Frontiers in psychology}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1664-1078}, doi = {10.3389/fpsyg.2022.1032006}, pages = {11}, year = {2022}, abstract = {This study aimed to validate the Norwegian version of the Basic Psychological Need Satisfaction and Frustration Scale (BPNSFS) and to examine its relations with indicators of well-being and ill-being. Additionally, despite the vast number of studies employing the BPNSFS, norms related to the BPNSFS are currently lacking. Therefore, we also aimed to provide normative data for this scale. Data were collected among a representative sample of 326 participants (M age = 42.90 years, SD = 14.76; range 18-70) in Norway, of which 49.7\% was female. Results yielded evidence for a six-factor structure (i.e., combining satisfaction/frustration with the type of need) and showed the subscales to be highly reliable. Subsequent structural equation modeling showed that both need satisfaction and need frustration related strongly to vitality, life satisfaction, and internalizing symptoms, but in opposite ways. Norm scores were provided, thereby differentiating between women and men and different age groups. These findings support the use of the Norwegian BPNSFS and provide researchers and professionals with normative data on the most widely used tool to assess individuals' satisfaction and frustration of the basic psychological needs for autonomy, competence, and relatedness.}, language = {en} }