@article{KoehlerHandorfJaiseretal.2021,
  author    = {K{\"o}hler, Raphael H. and Handorf, D{\"o}rthe and Jaiser, Ralf and Dethloff, Klaus and Z{\"a}ngl, G{\"u}nther and Majewski, Detlev and Rex, Markus},
  title     = {Improved circulation in the Northern hemisphere by adjusting gravity wave drag parameterizations in seasonal experiments with ICON-NWP},
  series = {Earth and Space Science : ESS},
  volume    = {8},
  journal   = {Earth and Space Science : ESS},
  number    = {3},
  publisher = {American Geophysical Union},
  address   = {Malden, Mass.},
  issn      = {2333-5084},
  doi       = {10.1029/2021EA001676},
  pages     = {15},
  year      = {2021},
  abstract  = {The stratosphere is one of the main potential sources for subseasonal to seasonal predictability in midlatitudes in winter. The ability of an atmospheric model to realistically simulate the stratospheric dynamics is essential in order to move forward in the field of seasonal predictions in midlatitudes. Earlier studies with the ICOsahedral Nonhydrostatic atmospheric model (ICON) point out that stratospheric westerlies in ICON are underestimated. This is the first extensive study on the evaluation of Northern Hemisphere stratospheric winter circulation with ICON in numerical weather prediction (NWP) mode. Seasonal experiments with the default setup are able to reproduce the basic climatology of the stratospheric polar vortex. However, westerlies are too weak and major stratospheric warmings too frequent in ICON. Both a reduction of the nonorographic, and a reduction of the orographic gravity wave and wake drag lead to a strengthening of the stratospheric vortex and a bias reduction, in particular in January. However, the effect of the nonorographic gravity wave drag scheme on the stratosphere is stronger. Stratosphere-troposphere coupling is intensified and more realistic due to a reduced gravity wave drag. Furthermore, an adjustment of the subgrid-scale orographic drag parameterization leads to a significant error reduction in the mean sea level pressure. As a result of these findings, we present our current suggested improved setup for seasonal experiments with ICON-NWP. <br /> Plain Language Summary Although seasonal forecasts for midlatitudes have the potential to be highly beneficial to the public sector, they are still characterized by a large amount of uncertainty. Exact simulations of the circulation in the stratosphere can help to improve tropospheric predictability on seasonal time scales. For this reason, we investigate how well the new German atmospheric model is able to simulate the stratospheric circulation. The model reproduces the basic behavior of the Northern Hemisphere stratospheric polar vortex, but the westerly circulation in winter is underestimated. The stratospheric circulation is influenced by gravity waves that exert drag on the flow. These processes are only partly physically represented in the model, but are very important and are hence parameterized. By adjusting the parameterizations for the gravity wave drag, the stratospheric polar vortex is strengthened, thereby yielding a more realistic stratospheric circulation. In addition, the altered parameterizations improve the simulated surface pressure pattern. Based upon this, we present our current suggested improved model setup for seasonal experiments.},
  language  = {en}
}
@article{HartmannHasenkampMayeretal.2015,
  author    = {Hartmann, Stefanie and Hasenkamp, Natascha and Mayer, Jens and Michaux, Johan and Morand, Serge and Mazzoni, Camila J. and Roca, Alfred L. and Greenwood, Alex D.},
  title     = {Endogenous murine leukemia retroviral variation across wild European and inbred strains of house mouse},
  series = {BMC genomics},
  volume    = {16},
  journal   = {BMC genomics},
  publisher = {BioMed Central},
  address   = {London},
  issn      = {1471-2164},
  doi       = {10.1186/s12864-015-1766-z},
  pages     = {13},
  year      = {2015},
  abstract  = {Background: Endogenous murine leukemia retroviruses (MLVs) are high copy number proviral elements difficult to comprehensively characterize using standard low throughput sequencing approaches. However, high throughput approaches generate data that is challenging to process, interpret and present. Results: Next generation sequencing (NGS) data was generated for MLVs from two wild caught Mus musculus domesticus (from mainland France and Corsica) and for inbred laboratory mouse strains C3H, LP/J and SJL. Sequence reads were grouped using a novel sequence clustering approach as applied to retroviral sequences. A Markov cluster algorithm was employed, and the sequence reads were queried for matches to specific xenotropic (Xmv), polytropic (Pmv) and modified polytropic (Mpmv) viral reference sequences. Conclusions: Various MLV subtypes were more widespread than expected among the mice, which may be due to the higher coverage of NGS, or to the presence of similar sequence across many different proviral loci. The results did not correlate with variation in the major MLV receptor Xpr1, which can restrict exogenous MLVs, suggesting that endogenous MLV distribution may reflect gene flow more than past resistance to infection.},
  language  = {en}
}
@article{RomanowskyHandorfJaiseretal.2019,
  author    = {Romanowsky, Erik and Handorf, D{\"o}rthe and Jaiser, Ralf and Wohltmann, Ingo and Dorn, Wolfgang and Ukita, Jinro and Cohen, Judah and Dethloff, Klaus and Rex, Markus},
  title     = {The role of stratospheric ozone for Arctic-midlatitude linkages},
  series = {Scientific reports},
  volume    = {9},
  journal   = {Scientific reports},
  publisher = {Nature Publ. Group},
  address   = {London},
  issn      = {2045-2322},
  doi       = {10.1038/s41598-019-43823-1},
  pages     = {7},
  year      = {2019},
  abstract  = {Arctic warming was more pronounced than warming in midlatitudes in the last decades making this region a hotspot of climate change. Associated with this, a rapid decline of sea-ice extent and a decrease of its thickness has been observed. Sea-ice retreat allows for an increased transport of heat and momentum from the ocean up to the tropo- and stratosphere by enhanced upward propagation of planetary-scale atmospheric waves. In the upper atmosphere, these waves deposit the momentum transported, disturbing the stratospheric polar vortex, which can lead to a breakdown of this circulation with the potential to also significantly impact the troposphere in mid- to late-winter and early spring. Therefore, an accurate representation of stratospheric processes in climate models is necessary to improve the understanding of the impact of retreating sea ice on the atmospheric circulation. By modeling the atmospheric response to a prescribed decline in Arctic sea ice, we show that including interactive stratospheric ozone chemistry in atmospheric model calculations leads to an improvement in tropo-stratospheric interactions compared to simulations without interactive chemistry. This suggests that stratospheric ozone chemistry is important for the understanding of sea ice related impacts on atmospheric dynamics.},
  language  = {en}
}
@article{NumbergerDreierVullioudetal.2019,
  author    = {Numberger, Daniela and Dreier, Carole and Vullioud, Colin and Gabriel, G{\"u}lsah and Greenwood, Alex D. and Grossart, Hans-Peter},
  title     = {Recovery of influenza a viruses from lake water and sediments by experimental inoculation},
  series = {PLoS one},
  volume    = {14},
  journal   = {PLoS one},
  number    = {5},
  publisher = {PLoS},
  address   = {San Fransisco},
  issn      = {1932-6203},
  doi       = {10.1371/journal.pone.0216880},
  pages     = {13},
  year      = {2019},
  abstract  = {Influenza A viruses (IAV) are zoonotic pathogens relevant to human, domestic animal and wildlife health. Many avian IAVs are transmitted among waterfowl via a faecal-oral-route. Therefore, environmental water where waterfowl congregate may play an important role in the ecology and epidemiology of avian IAV. Water and sediment may sustain and transmit virus among individuals or species. It is unclear at what concentrations waterborne viruses are infectious or remain detectable. To address this, we performed lake water and sediment dilution experiments with varying concentrations or infectious doses of four IAV strains from seal, turkey, duck and gull. To test for infectivity of the IAV strains in a concentration dependent manner, we applied cultivation to specific pathogen free (SPF) embryonated chicken eggs and Madin-Darby Canine Kidney (MDCK) cells. IAV recovery was more effective from embryonated chicken eggs than MDCK cells for freshwater lake dilutions, whereas, MDCK cells were more effective for viral recovery from sediment samples. Low infectious dose (1 PFU/200 mu L) was sufficient in most cases to detect and recover IAV from lake water dilutions. Sediment required higher initial infectious doses (>= 100 PFU/200 mu L).},
  language  = {en}
}
@article{GischRobertBerlinetal.2022,
  author    = {Gisch, Ulrike Alexandra and Robert, Margaux and Berlin, Noemi and Nebout, Antoine and Etile, Fabrice and Teyssier, Sabrina and Andreeva, Valentina A. and Hercberg, Serge and Touvier, Mathilde and Peneau, Sandrine},
  title     = {Mastery is associated with weight status, food intake, snacking, and eating disorder symptoms in the NutriNet-Sante cohort study},
  series = {Frontiers in Nutrition},
  volume    = {9},
  journal   = {Frontiers in Nutrition},
  publisher = {Frontiers Media},
  address   = {Lausanne},
  issn      = {2296-861X},
  doi       = {10.3389/fnut.2022.871669},
  pages     = {13},
  year      = {2022},
  abstract  = {Mastery is a psychological resource that is defined as the extent to which individuals perceive having control over important circumstances of their lives. Although mastery has been associated with various physical and psychological health outcomes, studies assessing its relationship with weight status and dietary behavior are lacking. The aim of this cross-sectional study was to assess the relationship between mastery and weight status, food intake, snacking, and eating disorder (ED) symptoms in the NutriNet-Sante cohort study. Mastery was measured with the Pearlin Mastery Scale (PMS) in 32,588 adults (77.45\% female), the mean age was 50.04 (14.53) years. Height and weight were self-reported. Overall diet quality and food group consumption were evaluated with >= 3 self-reported 24-h dietary records (range: 3-27). Snacking was assessed with an ad-hoc question. ED symptoms were assessed with the Sick-Control-One-Fat-Food Questionnaire (SCOFF). Linear and logistic regression analyses were conducted to assess the relationship between mastery and weight status, food intake, snacking, and ED symptoms, controlling for sociodemographic and lifestyle characteristics. Females with a higher level of mastery were less likely to be underweight (OR: 0.88; 95\%CI: 0.84, 0.93), overweight [OR: 0.94 (0.91, 0.97)], or obese [class I: OR: 0.86 (0.82, 0.90); class II: OR: 0.76 (0.71, 0.82); class III: OR: 0.77 (0.69, 0.86)]. Males with a higher level of mastery were less likely to be obese [class III: OR: 0.75 (0.57, 0.99)]. Mastery was associated with better diet quality overall, a higher consumption of fruit and vegetables, seafood, wholegrain foods, legumes, non-salted oleaginous fruits, and alcoholic beverages and with a lower consumption of meat and poultry, dairy products, sugary and fatty products, milk-based desserts, and sweetened beverages. Mastery was also associated with lower snacking frequency [OR: 0.89 (0.86, 0.91)] and less ED symptoms [OR: 0.73 (0.71, 0.75)]. As mastery was associated with favorable dietary behavior and weight status, targeting mastery might be a promising approach in promoting healthy behaviors.},
  language  = {en}
}
@article{Philipowski2021,
  author    = {Philipowski, Katharina},
  title     = {Konrads ›Klage der Kunst‹ im Kontext von Sangspruchdichtung und allegorischem Ich-Erz{\"a}hlen},
  series = {Konrad von W{\"u}rzburg als Erz{\"a}hler},
  volume    = {10},
  journal   = {Konrad von W{\"u}rzburg als Erz{\"a}hler},
  number    = {Themenheft},
  publisher = {University of Oldenburg Press},
  address   = {Oldenburg},
  issn      = {2568-9967},
  doi       = {10.25619/BmE20214131},
  url       = {http://nbn-resolving.de/https://ojs.uni-oldenburg.de/ojs/index.php/bme/article/view/131},
  pages     = {57 -- 79},
  year      = {2021},
  abstract  = {Die ›Klage der Kunst‹ Konrads wird auf dem Hintergrund und in Bezug zur Sangspruchdichtung sowie der Textfamilie allegorischer Erz{\"a}hlungen in der ersten Person untersucht. W{\"a}hrend Strophik, Sangbarkeit und kunst-Thematik das Werk in den Kontext der Sangspruchdichtung r{\"u}cken, stellt es sich durch seinen Umfang, seine Narrativit{\"a}t und das Erz{\"a}hltempus, das die Handlung zwar nicht dominiert, aber rahmt, an die Seite erster fr{\"u}her Erz{\"a}hlexperimente, die Dialog, Streit oder Rede als erlebte Erfahrung eines Ich pr{\"a}sentieren wie das ›Frauenbuch‹ Ulrichs von Liechtenstein, das aber - {\"a}hnlich wie Konrads ›Klage der Kunst‹ - zu seiner Zeit offenbar nur m{\"a}ßig erfolgreich, jedenfalls nur unikal {\"u}berliefert, ist. Konrad scheint der erste zu sein, der in der h{\"o}fischen Literatur das Erz{\"a}hlen in der ersten Person mit Allegorizit{\"a}t verkn{\"u}pft. Er nutzt dieses neue und in der sp{\"a}teren Literatur so {\"u}beraus fruchtbare Erz{\"a}hlformat geschickt, um seine eigene literarische Meisterschaft unter anderem in den Gestalten von wildekeit und kunst unter Beweis zu stellen, zu thematisieren und szenisch zu verhandeln.},
  language  = {de}
}
@article{GorinScherzKorostetal.2021,
  author    = {Gorin, Vladislav A. and Scherz, Mark D. and Korost, Dmitry V. and Poyarkov, Nikolay A.},
  title     = {Consequences of parallel miniaturisation in Microhylinae (Anura, Microhylidae), with the description of a new genus of diminutive South East Asian frogs},
  series = {Zoosystematics and evolution : Mitteilungen aus dem Museum f{\"u}r Naturkunde in Berlin},
  volume    = {97},
  journal   = {Zoosystematics and evolution : Mitteilungen aus dem Museum f{\"u}r Naturkunde in Berlin},
  number    = {1},
  publisher = {Pensoft Publishers},
  address   = {Sofia},
  issn      = {1860-0743},
  doi       = {10.3897/zse.97.57968},
  pages     = {21 -- 54},
  year      = {2021},
  abstract  = {The genus Microhyla Tschudi, 1838 includes 52 species and is one of the most diverse genera of the family Microhylidae, being the most species-rich taxon of the Asian subfamily Microhylinae. The recent, rapid description of numerous new species of Microhyla with complex phylogenetic relationships has made the taxonomy of the group especially challenging. Several recent phylogenetic studies suggested paraphyly of Microhyla with respect to Glyphoglossus Gunther, 1869, and revealed three major phylogenetic lineages of mid-Eocene origin within this assemblage. However, comprehensive works assessing morphological variation among and within these lineages are absent. In the present study we investigate the generic taxonomy of Microhyla-Glyphoglossus assemblage based on a new phylogeny including 57 species, comparative morphological analysis of skeletons from cleared-and-stained specimens for 23 species, and detailed descriptions of generalized osteology based on volume-rendered micro-CT scans for five speciesal-together representing all major lineages within the group. The results confirm three highly divergent and well-supported clades that correspond with external and osteological morphological characteristics, as well as respective geographic distribution. Accordingly, acknowledging ancient divergence between these lineages and their significant morphological differentiation, we propose to consider these three lineages as distinct genera: Microhyla sensu stricto, Glyphoglossus, and a newly described genus, Nanohyla gen. nov.},
  language  = {en}
}
@article{ReilRosenfeldImholtetal.2017,
  author    = {Reil, Daniela and Rosenfeld, Ulrike and Imholt, Christian and Schmidt, Sabrina and Ulrich, Rainer G. and Eccard, Jana and Jacob, Jens},
  title     = {Puumala hantavirus infections in bank vole populations},
  series = {BMC ecology},
  volume    = {17},
  journal   = {BMC ecology},
  publisher = {BioMed Central},
  address   = {London},
  issn      = {1472-6785},
  doi       = {10.1186/s12898-017-0118-z},
  pages     = {13},
  year      = {2017},
  abstract  = {Background In Europe, bank voles (Myodes glareolus) are widely distributed and can transmit Puumala virus (PUUV) to humans, which causes a mild to moderate form of haemorrhagic fever with renal syndrome, called nephropathia epidemica. Uncovering the link between host and virus dynamics can help to prevent human PUUV infections in the future. Bank voles were live trapped three times a year in 2010-2013 in three woodland plots in each of four regions in Germany. Bank vole population density was estimated and blood samples collected to detect PUUV specific antibodies. Results We demonstrated that fluctuation of PUUV seroprevalence is dependent not only on multi-annual but also on seasonal dynamics of rodent host abundance. Moreover, PUUV infection might affect host fitness, because seropositive individuals survived better from spring to summer than uninfected bank voles. Individual space use was independent of PUUV infections. Conclusions Our study provides robust estimations of relevant patterns and processes of the dynamics of PUUV and its rodent host in Central Europe, which are highly important for the future development of predictive models for human hantavirus infection risk},
  language  = {en}
}
@article{WitzelAbuRishaAlbersetal.2019,
  author    = {Witzel, Katja and Abu Risha, Marua and Albers, Philip and B{\"o}rnke, Frederik and Hanschen, Franziska S.},
  title     = {Identification and Characterization of Three Epithiospecifier Protein Isoforms in Brassica oleracea},
  series = {Frontiers in plant science},
  volume    = {10},
  journal   = {Frontiers in plant science},
  publisher = {Frontiers Research Foundation},
  address   = {Lausanne},
  issn      = {1664-462X},
  doi       = {10.3389/fpls.2019.01552},
  pages     = {14},
  year      = {2019},
  abstract  = {Glucosinolates present in Brassicaceae play a major role in herbivory defense. Upon tissue disruption, glucosinolates come into contact with myrosinase, which initiates their breakdown to biologically active compounds. Among these, the formation of epithionitriles is triggered by the presence of epithiospecifier protein (ESP) and a terminal double bond in the glucosinolate side chain. One ESP gene is characterized in the model plant Arabidopsis thaliana (AtESP; At1g54040.2). However, Brassica species underwent genome triplication since their divergence from the Arabidopsis lineage. This indicates the presence of multiple ESP isoforms in Brassica crops that are currently poorly characterized. We identified three B. oleracea ESPs, specifically BoESP1 (LOC106296341), BoESP2 (LOC106306810), and BoESP3 (LOC106325105) based on in silico genome analysis. Transcript and protein abundance were assessed in shoots and roots of four B. oleracea vegetables, namely broccoli, kohlrabi, white, and red cabbage, because these genotypes showed a differential pattern for the formation of glucosinolate hydrolysis products as well for their ESP activity. BoESP1 and BoESP2 were expressed mainly in shoots, while BoESP3 was abundant in roots. Biochemical characterization of heterologous expressed BoESP isoforms revealed different substrate specificities towards seven glucosinolates: all isoforms showed epithiospecifier activity on alkenyl glucosinolates, but not on non-alkenyl glucosinolates. The pH-value differently affected BoESP activity: while BoESP1 and BoESP2 activities were optimal at pH 6-7, BoESP3 activity remained relatively stable from pH 4 to 7. In order test their potential for the in vivo modification of glucosinolate breakdown, the three isoforms were expressed in A. thaliana Hi-0, which lacks AtESP expression, and analyzed for the effect on their respective hydrolysis products. The BoESPs altered the hydrolysis of allyl glucosinolate in the A. thaliana transformants to release 1-cyano-2,3-epithiopropane and reduced formation of the corresponding 3-butenenitrile and allyl isothiocyanate. Plants expressing BoESP2 showed the highest percentage of released epithionitriles. Given these results, we propose a model for isoform-specific roles of B. oleracea ESPs in glucosinolate breakdown.},
  language  = {en}
}
@article{GrumHiesslMareschetal.2021,
  author    = {Grum, Marcus and Hiessl, Werner and Maresch, Karl and Gronau, Norbert},
  title     = {Design of a neuronal training modeling language},
  series = {AIS-Transactions on enterprise systems},
  volume    = {5},
  journal   = {AIS-Transactions on enterprise systems},
  number    = {1},
  publisher = {GITO-Publ., Verl. f{\"u}r Industrielle Informationstechnik und Organisation},
  address   = {Berlin},
  issn      = {1867-7134},
  doi       = {10.30844/aistes.v5i1.20},
  pages     = {16},
  year      = {2021},
  abstract  = {As the complexity of learning task requirements, computer infrastruc- tures and knowledge acquisition for artificial neuronal networks (ANN) is in- creasing, it is challenging to talk about ANN without creating misunderstandings. An efficient, transparent and failure-free design of learning tasks by models is not supported by any tool at all. For this purpose, particular the consideration of data, information and knowledge on the base of an integration with knowledge- intensive business process models and a process-oriented knowledge manage- ment are attractive. With the aim of making the design of learning tasks express- ible by models, this paper proposes a graphical modeling language called Neu- ronal Training Modeling Language (NTML), which allows the repetitive use of learning designs. An example ANN project of AI-based dynamic GUI adaptation exemplifies its use as a first demonstration.},
  language  = {en}
}