@article{SchroeterNeugartSchreineretal.2019, author = {Schr{\"o}ter, David and Neugart, Susanne and Schreiner, Monika and Grune, Tilman and Rohn, Sascha and Ott, Christiane}, title = {Amaranth's 2-Caffeoylisocitric Acid—An Anti-Inflammatory Caffeic Acid Derivative That Impairs NF-κB Signaling in LPS-Challenged RAW 264.7 Macrophages}, series = {Nutrients}, volume = {11}, journal = {Nutrients}, number = {3}, publisher = {MDPI}, address = {Basel}, issn = {2072-6643}, doi = {10.3390/nu11030571}, pages = {14}, year = {2019}, abstract = {For centuries, Amaranthus sp. were used as food, ornamentals, and medication. Molecular mechanisms, explaining the health beneficial properties of amaranth, are not yet understood, but have been attributed to secondary metabolites, such as phenolic compounds. One of the most abundant phenolic compounds in amaranth leaves is 2-caffeoylisocitric acid (C-IA) and regarding food occurrence, C-IA is exclusively found in various amaranth species. In the present study, the anti-inflammatory activity of C-IA, chlorogenic acid, and caffeic acid in LPS-challenged macrophages (RAW 264.7) has been investigated and cellular contents of the caffeic acid derivatives (CADs) were quantified in the cells and media. The CADs were quantified in the cell lysates in nanomolar concentrations, indicating a cellular uptake. Treatment of LPS-challenged RAW 264.7 cells with 10 µM of CADs counteracted the LPS effects and led to significantly lower mRNA and protein levels of inducible nitric oxide synthase, tumor necrosis factor alpha, and interleukin 6, by directly decreasing the translocation of the nuclear factor κB/Rel-like containing protein 65 into the nucleus. This work provides new insights into the molecular mechanisms that attribute to amaranth's anti-inflammatory properties and highlights C-IA's potential as a health-beneficial compound for future research.}, language = {en} } @article{FrankenDegelingPreisfeld2023, author = {Franken, Nadine and Degeling, Maria and Preisfeld, Angelika}, title = {Am Puls der (digitalen) Zeit?}, series = {Reflexion in der Lehrkr{\"a}ftebildung: Empirisch - Phasen{\"u}bergreifend - Interdisziplin{\"a}r (Potsdamer Beitr{\"a}ge zur Lehrerbildung und Bildungsforschung ; 4)}, journal = {Reflexion in der Lehrkr{\"a}ftebildung: Empirisch - Phasen{\"u}bergreifend - Interdisziplin{\"a}r (Potsdamer Beitr{\"a}ge zur Lehrerbildung und Bildungsforschung ; 4)}, number = {4}, editor = {Mientus, Lukas and Klempin, Christiane and Nowak, Anna}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-566-8}, issn = {2626-3556}, doi = {10.25932/publishup-63140}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-631402}, pages = {221 -- 231}, year = {2023}, abstract = {In diesem Beitrag wird ein geplantes digitales Lehrkonzept f{\"u}r die universit{\"a}re Begleitung des Praxissemesters in den F{\"a}chern Biologie und Mathematik vorgestellt. Darin setzen sich Studierende im Praxissemester selbstst{\"a}ndig fachspezifische Schwerpunkte f{\"u}r die Planung, Durchf{\"u}hrung und Reflexion von Unterrichtsprojekten in der Schule. Optimalerweise ergibt sich aus den Unterrichtsprojekten auch eine fachbezogene Fragestellung, die von den Studierenden im Zuge Forschenden Lernens ergr{\"u}ndet werden kann. Begleitet wird der gesamte Prozess durch systematisch angeleitete E-Peer-Assessments (E-PA). Dabei treten Studierende in Peers in den digitalen, schriftlichen Dialog {\"u}ber Unterricht und durchlaufen gemeinsam Reflexions- und Feedbackschleifen, welche durch die universit{\"a}re Seminarleitung instruiert werden.}, language = {de} } @article{BadePicatChungetal.2022, author = {Bade, Nadine and Picat, Leo and Chung, WooJin and Mascarenhas, Salvador}, title = {Alternatives and attention in language and reasoning: A reply to Mascarenhas \& Picat (2019)}, series = {Semantics and Pragmatics}, volume = {15}, journal = {Semantics and Pragmatics}, publisher = {Linguistic Society of America}, address = {Washington}, issn = {1937-8912}, doi = {10.3765/sp.15.2}, pages = {31}, year = {2022}, abstract = {In this paper, we employ an experimental paradigm using insights from the psychology of reasoning to investigate the question whether certain modals generate and draw attention to alternatives. The article extends and builds on the methodology and findings of Mascarenhas \& Picat (2019). Based on experimental results, they argue that the English epistemic modal might raises alternatives. We apply the same methodology to the English modal allowed to to test different hypotheses regarding the involvement of alternatives in deontic modality. We find commonalities and differences between the two modals we tested. We discuss theoretical consequences for existing semantic analyses of these modals, and argue that reasoning tasks can serve as a diagnostic tool to discover which natural language expressions involve alternatives.}, language = {en} } @article{StreflerKrieglerBaueretal.2021, author = {Strefler, Jessica and Kriegler, Elmar and Bauer, Nico and Luderer, Gunnar and Pietzcker, Robert C. and Giannousakis, Anastasis and Edenhofer, Ottmar}, title = {Alternative carbon price trajectories can avoid excessive carbon removal}, series = {Nature communications}, volume = {12}, journal = {Nature communications}, number = {1}, publisher = {Nature Publishing Group}, address = {London}, issn = {2041-1723}, doi = {10.1038/s41467-021-22211-2}, pages = {8}, year = {2021}, abstract = {The large majority of climate change mitigation scenarios that hold warming below 2 °C show high deployment of carbon dioxide removal (CDR), resulting in a peak-and-decline behavior in global temperature. This is driven by the assumption of an exponentially increasing carbon price trajectory which is perceived to be economically optimal for meeting a carbon budget. However, this optimality relies on the assumption that a finite carbon budget associated with a temperature target is filled up steadily over time. The availability of net carbon removals invalidates this assumption and therefore a different carbon price trajectory should be chosen. We show how the optimal carbon price path for remaining well below 2 °C limits CDR demand and analyze requirements for constructing alternatives, which may be easier to implement in reality. We show that warming can be held at well below 2 °C at much lower long-term economic effort and lower CDR deployment and therefore lower risks if carbon prices are high enough in the beginning to ensure target compliance, but increase at a lower rate after carbon neutrality has been reached.}, language = {en} } @article{JonasSchwerbelZellneretal.2022, author = {Jonas, Wenke and Schwerbel, Kristin and Zellner, Lisa and J{\"a}hnert, Markus and Gottmann, Pascal and Sch{\"u}rmann, Annette}, title = {Alterations of lipid profile in livers with impaired lipophagy}, series = {International journal of molecular sciences}, volume = {23}, journal = {International journal of molecular sciences}, number = {19}, publisher = {MDPI}, address = {Basel}, issn = {1422-0067}, doi = {10.3390/ijms231911863}, pages = {12}, year = {2022}, abstract = {Non-alcoholic fatty liver disease (NAFLD) is characterized by excessive lipid accumulation in the liver. Various mechanisms such as an increased uptake in fatty acids or de novo synthesis contribute to the development of steatosis and progression to more severe stages. Furthermore, it has been shown that impaired lipophagy, the degradation of lipids by autophagic processes, contributes to NAFLD. Through an unbiased lipidome analysis of mouse livers in a genetic model of impaired lipophagy, we aimed to determine the resulting alterations in the lipidome. Observed changes overlap with those of the human disease. Overall, the entire lipid content and in particular the triacylglycerol concentration increased under conditions of impaired lipophagy. In addition, we detected a reduction in long-chain polyunsaturated fatty acids (PUFAs) and an increased ratio of n-6 PUFAs to n-3 PUFAs, which was due to the depletion of n-3 PUFAs. Although the abundance of major phospholipid classes was reduced, the ratio of phosphatidylcholines to phosphatidylethanolamines was not affected. In conclusion, this study demonstrates that impaired lipophagy contributes to the pathology of NAFLD and is associated with an altered lipid profile. However, the lipid pattern does not appear to be specific for lipophagic alterations, as it resembles mainly that described in relation to fatty liver disease.}, language = {en} } @article{BuschBlasimannMayeretal.2021, author = {Busch, Aglaja and Blasimann, Angela and Mayer, Frank and Baur, Heiner}, title = {Alterations in sensorimotor function after ACL reconstruction during active joint position sense testing. A systematic review}, series = {PLOS ONE}, volume = {16}, journal = {PLOS ONE}, number = {6}, publisher = {PLOS}, address = {San Francisco}, issn = {1932-6203}, doi = {10.1371/journal.pone.0253503}, pages = {14}, year = {2021}, abstract = {Background The anterior cruciate ligament (ACL) rupture can lead to impaired knee function. Reconstruction decreases the mechanical instability but might not have an impact on sensorimotor alterations. Objective Evaluation of the sensorimotor function measured with the active joint position sense (JPS) test in anterior cruciate ligament (ACL) reconstructed patients compared to the contralateral side and a healthy control group. Methods The databases MEDLINE, CINAHL, EMBASE, PEDro, Cochrane Library and SPORTDiscus were systematically searched from origin until April 2020. Studies published in English, German, French, Spanish or Italian language were included. Evaluation of the sensorimotor performance was restricted to the active joint position sense test in ACL reconstructed participants or healthy controls. The Preferred Items for Systematic Reviews and Meta-Analyses guidelines were followed. Study quality was evaluated using the Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies. Data was descriptively synthesized. Results Ten studies were included after application of the selective criteria. Higher angular deviation, reaching significant difference (p < 0.001) in one study, was shown up to three months after surgery in the affected limb. Six months post-operative significantly less error (p < 0.01) was found in the reconstructed leg compared to the contralateral side and healthy controls. One or more years after ACL reconstruction significant differences were inconsistent along the studies. Conclusions Altered sensorimotor function was present after ACL reconstruction. Due to inconsistencies and small magnitudes, clinical relevance might be questionable. JPS testing can be performed in acute injured persons and prospective studies could enhance knowledge of sensorimotor function throughout the rehabilitative processes.}, language = {en} } @article{MachlebSeyboth2021, author = {Machleb, Franziska and Seyboth, Margret}, title = {Alles kann besser werden!}, series = {Spektrum Patholinguistik}, journal = {Spektrum Patholinguistik}, number = {14}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-507-1}, issn = {1866-9085}, doi = {10.25932/publishup-51041}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-510412}, pages = {121 -- 137}, year = {2021}, language = {de} } @article{SchubarthMauermeisterSchulzeReicheltetal.2020, author = {Schubarth, Wilfried and Mauermeister, Sylvi and Schulze-Reichelt, Friederike and Erdmann, Melinda}, title = {Alles auf (Studien-)Anfang? Faktoren f{\"u}r den Studienerfolg in der Eingangsphase und zur Studienmitte}, series = {Potsdamer Beitr{\"a}ge zur Hochschulforschung}, journal = {Potsdamer Beitr{\"a}ge zur Hochschulforschung}, number = {6}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-498-2}, issn = {2192-1075}, doi = {10.25932/publishup-49262}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-492623}, pages = {27 -- 54}, year = {2020}, abstract = {Die hohen Abbruchquoten, insbesondere in der Studieneingangsphase, haben die Hochschulen in Deutschland veranlasst, eine Vielzahl von Maßnahmen zu ergreifen, {\"u}ber deren Wirkungen bisher allerdings wenig bekannt ist. Im vorliegenden Beitrag werden Befunde eines Forschungsprojekts speziell zur Studieneingangsphase sowie erg{\"a}nzend zur Studienmitte vorgestellt, dessen Ziel es war, Bedingungen eines erfolgreichen Studieneinstiegs zu identifizieren und Empfehlungen f{\"u}r eine Optimierung des Studieneingangs abzuleiten. Das Forschungsdesign umfasste neben qualitativen Studien vor allem eine quantitative L{\"a}ngsschnittbefragung an f{\"u}nf Universit{\"a}ten (Potsdam, Mainz, Magdeburg, Kiel und Greifswald). Im Ergebnis der Analysen konnte die forschungsleitende Hypothese, dass Maßnahmen zum Studieneingang vor allem dann zur Erh{\"o}hung des Studienerfolgs einen Beitrag leisten, wenn sie zur akademischen und sozialen Integration in die Hochschule beitragen, best{\"a}tigt werden. Bedeutsam f{\"u}r den Studienerfolg sind demnach insbesondere solche Faktoren wie die Identifikation mit dem Studienfach, die Selbstwirksamkeit, die berufliche bzw. erfolgsorientierte Lernmotivation und die akademische Integration. Daneben konnte ein positiver Einfluss des sozialen Klimas sowie des Forschungs- und Praxisbezugs auf die Studienzufriedenheit nachgewiesen werden. Weiterf{\"u}hrende Analysen zur Studienmitte verdeutlichen zudem, dass f{\"u}r die beiden Studienphasen (Eingang und Studienmitte) gleiche Faktoren bei zum Teil unterschiedlicher Gewichtung eine Rolle spielen. So ist die soziale Integration ein wesentlicher Pr{\"a}diktor in beiden Phasen - in der Eingangsphase eher in die Studierendenschaft und im weiteren Studienverlauf (Studienmitte) eher in die akademische Gemeinschaft (in Form von Lehrenden). Insofern muss die Eingangsfrage wie folgt beantwortet werden: Ja, alles auf Anfang, aber dann mit den Bem{\"u}hungen, soziale und akademische Integration aller Studierenden voll und ganz zu gew{\"a}hrleisten. Zudem machen die Befunde auf die bisher offenbar untersch{\"a}tzte Rolle von Verwertungsmotiven aufmerksam.}, language = {de} } @article{WarszawskiKrieglerLentonetal.2021, author = {Warszawski, Lila and Kriegler, Elmar and Lenton, Timothy M. and Gaffney, Owen and Jacob, Daniela and Klingenfeld, Daniel and Koide, Ryu and Costa, Mar{\´i}a M{\´a}{\~n}ez and Messner, Dirk and Nakicenovic, Nebojsa and Schellnhuber, Hans Joachim and Schlosser, Peter and Takeuchi, Kazuhiko and van der Leeuw, Sander and Whiteman, Gail and Rockstr{\"o}m, Johan}, title = {All options, not silver bullets, needed to limit global warming to 1.5 °C}, series = {Environmental research letters}, volume = {16}, journal = {Environmental research letters}, number = {6}, publisher = {IOP Publishing}, address = {Bristol}, issn = {1748-9326}, doi = {10.1088/1748-9326/abfeec}, pages = {15}, year = {2021}, abstract = {Climate science provides strong evidence of the necessity of limiting global warming to 1.5 °C, in line with the Paris Climate Agreement. The IPCC 1.5 °C special report (SR1.5) presents 414 emissions scenarios modelled for the report, of which around 50 are classified as '1.5 °C scenarios', with no or low temperature overshoot. These emission scenarios differ in their reliance on individual mitigation levers, including reduction of global energy demand, decarbonisation of energy production, development of land-management systems, and the pace and scale of deploying carbon dioxide removal (CDR) technologies. The reliance of 1.5 °C scenarios on these levers needs to be critically assessed in light of the potentials of the relevant technologies and roll-out plans. We use a set of five parameters to bundle and characterise the mitigation levers employed in the SR1.5 1.5 °C scenarios. For each of these levers, we draw on the literature to define 'medium' and 'high' upper bounds that delineate between their 'reasonable', 'challenging' and 'speculative' use by mid century. We do not find any 1.5 °C scenarios that stay within all medium upper bounds on the five mitigation levers. Scenarios most frequently 'over use' CDR with geological storage as a mitigation lever, whilst reductions of energy demand and carbon intensity of energy production are 'over used' less frequently. If we allow mitigation levers to be employed up to our high upper bounds, we are left with 22 of the SR1.5 1.5 °C scenarios with no or low overshoot. The scenarios that fulfil these criteria are characterised by greater coverage of the available mitigation levers than those scenarios that exceed at least one of the high upper bounds. When excluding the two scenarios that exceed the SR1.5 carbon budget for limiting global warming to 1.5 °C, this subset of 1.5 °C scenarios shows a range of 15-22 Gt CO2 (16-22 Gt CO2 interquartile range) for emissions in 2030. For the year of reaching net zero CO2 emissions the range is 2039-2061 (2049-2057 interquartile range).}, language = {en} } @article{MientusWulffNowaketal.2023, author = {Mientus, Lukas and Wulff, Peter and Nowak, Anna and Borowski, Andreas}, title = {Algorithmen als Dozierende?}, series = {PSI-Potsdam: Ergebnisbericht zu den Aktivit{\"a}ten im Rahmen der Qualit{\"a}tsoffensive Lehrerbildung (2019-2023) (Potsdamer Beitr{\"a}ge zur Lehrerbildung und Bildungsforschung ; 3)}, journal = {PSI-Potsdam: Ergebnisbericht zu den Aktivit{\"a}ten im Rahmen der Qualit{\"a}tsoffensive Lehrerbildung (2019-2023) (Potsdamer Beitr{\"a}ge zur Lehrerbildung und Bildungsforschung ; 3)}, number = {3}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-568-2}, issn = {2626-3556}, doi = {10.25932/publishup-61640}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-616407}, pages = {117 -- 129}, year = {2023}, abstract = {Auf maschinellem Lernen basierende Tools haben schon l{\"a}ngst Einzug in unseren Alltag gefunden und so konnten auch in der Lehrkr{\"a}ftebildung erste Anwendungen entwickelt, erprobt und evaluiert werden. Im Teilprojekt Physikdidaktik des Schwerpunktes 2 „Schulpraktische Studien" wurden auf Basis eines Rahmenmodells f{\"u}r Reflexion (Nowak et al., 2019) automatisierte Analysemethoden (Wulff et al., 2020) entwickelt und fanden Einzug in universit{\"a}re fachdidaktische Lehre (Mientus et al., 2021a). Mit dem Projekt konnten Potenziale KI-basierter Unterst{\"u}tzung aufgezeigt und verstetigt sowie spezifische Herausforderungen identifiziert werden. Dieser Beitrag skizziert ausgew{\"a}hlte Anwendungsm{\"o}glichkeiten und weiterf{\"u}hrende Forschungen unter dem Gesichtspunkt der Akzeptanz computerunterst{\"u}tzter Lehre.}, language = {de} }