@article{TraxlerHanssenLautenbacheretal.2018, author = {Traxler, Juliane and Hanssen, Marjolein M. and Lautenbacher, Stefan and Ottawa, Fabian and Peters, Madelon L.}, title = {General versus pain-specific cognitions}, series = {European journal of pain}, volume = {23}, journal = {European journal of pain}, number = {1}, publisher = {Wiley}, address = {Hoboken}, issn = {1090-3801}, doi = {10.1002/ejp.1294}, pages = {150 -- 159}, year = {2018}, abstract = {Background Previous studies found evidence that dispositional optimism is related to lower pain sensitivity. Recent findings suggest that temporarily increasing optimism by means of imagining a positive future may also have pain-alleviating effects. Objectives The present experiment was designed to investigate conditioned pain modulation (CPM) as a potential underlying mechanism of this pain-alleviating effect of induced optimism. Methods For this purpose, 45 healthy participants were randomized into an optimistic or neutral imagery condition. Additionally, participants completed questionnaires on dispositional optimism, pain catastrophizing and pain expectations. CPM was assessed by delivering a series of five heat pain stimuli on the nondominant hand before and during immersion of the dominant hand in water of 5 degrees C for 70 s. Results A clear CPM effect was found, that is heat pain reports were lower during simultaneous cold water stimulation. Although the optimism manipulation successfully increased optimism, it did not affect pain ratings or CPM. Post hoc analyses indicated that dispositional optimism was not associated with the magnitude of CPM, but pain catastrophizing and pain expectations did significantly correlate with the CPM effect. Conclusion Pain-specific but not general cognitions appear to influence endogenous pain modulation. Significance Conditioned pain modulation is not the underlying mechanism of the pain-alleviating effects of induced optimism. However, pain-specific cognitions including pain catastrophizing and pain expectations affect endogenous pain modulation which should be taken into account in treatment and CPM research.}, language = {en} } @article{SalzwedelHeidlerMengetal.2020, author = {Salzwedel, Annett and Heidler, Maria-Dorothea and Meng, Karin and Schikora, Martin and Wegscheider, Karl and Reibis, Rona Katharina and V{\"o}ller, Heinz}, title = {Impact of cognitive performance on disease-related knowledge six months after multi-component rehabilitation in patients after an acute cardiac event}, series = {European journal of preventive cardiology : the official ESC journal for primary \& secondary cardiovascular prevention, rehabilitation and sports cardiology}, volume = {26}, journal = {European journal of preventive cardiology : the official ESC journal for primary \& secondary cardiovascular prevention, rehabilitation and sports cardiology}, number = {1}, publisher = {Sage Publ.}, address = {London}, issn = {2047-4873}, doi = {10.1177/2047487318791609}, pages = {46 -- 55}, year = {2020}, abstract = {Background Although associations between cardiovascular diseases and cognitive impairment are well known, the impact of cognitive performance on the success of patient education as a core component of cardiac rehabilitation remains insufficiently investigated so far. Design Prospective observational study in two inpatient cardiac rehabilitation centres between September 2014 and August 2015 with a follow-up six months after cardiac rehabilitation. Method At admission to and discharge from cardiac rehabilitation, the cognitive performance of 401 patients (54.5 ± 6.3 years, 80\% men) following an acute coronary syndrome and/or coronary artery bypass graft was tested using the Montreal Cognitive Assessment. Patients' disease-related knowledge was determined using a quiz (22 items for medical knowledge and 12 items for healthy lifestyle and behaviour) at both times and at follow-up. The change in knowledge after cardiac rehabilitation was analysed in multivariable regression models. Potentially influencing parameters (e.g. level of education, medication, cardiovascular risk factors, coronary artery bypass graft, comorbidities, exercise capacity) were considered. Results During cardiac rehabilitation, disease-related knowledge was significantly enhanced in both scales. At follow-up, the average level of medical knowledge was significantly reduced, while lifestyle knowledge remained at a stable level. The maintenance of knowledge after cardiac rehabilitation was predominantly predicted by prior knowledge, cognitive performance at discharge from cardiac rehabilitation and, in the case of medical knowledge, by coronary artery bypass graft. Conclusion Patient education in cardiac rehabilitation led to enhanced disease-related knowledge, but the maintenance of this essentially depended on patients' cognitive performance, especially after coronary artery bypass graft. Therefore, patient education concepts in cardiac rehabilitation should be reconsidered and adjusted as needed.}, language = {en} } @article{MainkaWisselVoelleretal.2018, author = {Mainka, Stefan and Wissel, J{\"o}rg and V{\"o}ller, Heinz and Evers, Stefan}, title = {The Use of Rhythmic Auditory Stimulation to Optimize Treadmill Training for Stroke Patients}, series = {Frontiers in Neurology}, volume = {9}, journal = {Frontiers in Neurology}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1664-2295}, doi = {10.3389/fneur.2018.00755}, pages = {8}, year = {2018}, abstract = {The use of functional music in gait training termed rhythmic auditory stimulation (RAS) and treadmill training (TT) have both been shown to be effective in stroke patients (SP). The combination of RAS and treadmill training (RAS-TT) has not been clinically evaluated to date. The aim of the study was to evaluate the efficacy of RAS-TT on functional gait in SR The protocol followed the design of an explorative study with a rater-blinded three arm prospective randomized controlled parallel group design. Forty-five independently walking SP with a hemiparesis of the lower limb or an unsafe and asymmetrical walking pattern were recruited. RAS-TT was carried out over 4 weeks with TT and neurodevelopmental treatment based on Bobath approach (NDT) serving as control interventions. For RAS-TT functional music was adjusted individually while walking on the treadmill. Pre and post-assessments consisted of the fast gait speed test (FGS), a gait analysis with the locometre (LOC), 3 min walking time test (3MWT), and an instrumental evaluation of balance (IEB). Raters were blinded to group assignments. An analysis of covariance (ANCOVA) was performed with affiliated measures from pre-assessment and time between stroke and start of study as covariates. Thirty-five participants (mean age 63.6 +/- 8.6 years, mean time between stroke and start of study 42.1 +/- 23.7 days) completed the study (11 RAS-TT, 13 TT, 11 NDT). Significant group differences occurred in the FGS for adjusted post-measures in gait velocity [F-(2,F- (34)) = 3.864, p = 0.032; partial eta(2) = 0.205] and cadence [F-(2,F- 34) = 7.656, p = 0.002; partial eta(2) = 0.338]. Group contrasts showed significantly higher values for RAS-TT. Stride length results did not vary between the groups. LOC, 3MWT, and IEB did not indicate group differences. One patient was withdrawn from TT because of pain in one arm. The study provides first evidence for a higher efficacy of RAS-TT in comparison to the standard approaches TT and NDT in restoring functional gait in SP. The results support the implementation of functional music in neurological gait rehabilitation and its use in combination with treadmill training.}, language = {en} } @misc{TammenKoemhoffMarketal.2018, author = {Tammen, Harald and Koemhoff, Martin and Mark, Michael and Hocher, Berthold and Delic, Denis and Hess, R{\"u}diger and von Eynatten, Maximilian and Klein, Thomas}, title = {Linagliptin treatment is associated with improved cobalamin (vitamin B-12) storage in mice and potentially in humans}, series = {Diabetologia : journal of the European Association for the Study of Diabetes (EASD)}, volume = {61}, journal = {Diabetologia : journal of the European Association for the Study of Diabetes (EASD)}, publisher = {Springer}, address = {New York}, issn = {0012-186X}, pages = {S252 -- S253}, year = {2018}, language = {en} } @article{SammoudNevillNegraetal.2018, author = {Sammoud, Senda and Nevill, Alan Michael and Negra, Yassine and Bouguezzi, Raja and Chaabene, Helmi and Hachana, Youn{\´e}s}, title = {Key somatic variables in young backstroke swimmers}, series = {Journal of sports sciences}, volume = {37}, journal = {Journal of sports sciences}, number = {10}, publisher = {Routledge, Taylor \& Francis Group}, address = {Abingdon}, issn = {0264-0414}, doi = {10.1080/02640414.2018.1546547}, pages = {1162 -- 1167}, year = {2018}, abstract = {The purpose of this study was to estimate the optimal body size, limb-segment length, girth or breadth ratios for 100-m backstroke mean speed performance in young swimmers. Sixty-three young swimmers (boys [n = 30; age: 13.98 ± 0.58 years]; girls [n = 33; age: 13.02 ± 1.20 years]) participated in this study. To identify the optimal body size and body composition components associated with 100-m backstroke speed performance, we adopted a multiplicative allometric log-linear regression model, which was refined using backward elimination. The multiplicative allometric model exploring the association between 100-m backstroke mean speed performance and the different somatic measurements estimated that biological age, sitting height, leg length for the lower-limbs, and two girths (forearm and arm relaxed girth) are the key predictors. Stature and body mass did not contribute to the model, suggesting that the advantage of longer levers was limb-specific rather than a general whole-body advantage. In fact, it is only by adopting multiplicative allometric models that the abovementioned ratios could have been derived. These findings highlighted the importance of considering somatic characteristics of young backstroke swimmers and can help swimming coaches to classify their swimmers and enable them to suggest what might be the swimmers' most appropriate stroke (talent identification).}, language = {en} } @misc{BruettMeisterBerngesetal.2017, author = {Br{\"u}tt, Anna Levke and Meister, Ramona and Bernges, Tabea and Moritz, Steffen and H{\"a}rter, Martin and Kriston, Levente and K{\"u}hne, Franziska}, title = {Patient involvement in a systematic review}, series = {Zeitschrift f{\"u}r Evidenz, Fortbildung und Qualit{\"a}t im Gesundheitswesen}, volume = {127-128}, journal = {Zeitschrift f{\"u}r Evidenz, Fortbildung und Qualit{\"a}t im Gesundheitswesen}, publisher = {Elsevier}, address = {Jena}, issn = {1865-9217}, doi = {10.1016/j.zefq.2017.07.005}, pages = {56 -- 61}, year = {2017}, abstract = {Patient involvement (PI) in research is increasingly required as a means to improve relevance and meaningfulness of research results. PI has been widely promoted by the National Institute for Health Research in England in the last years. In Germany, widespread involvement of patients in research is still missing. The methods used to realize PI have been developed mainly in English research contexts, and detailed information on how to involve patients in systematic reviews is rare. Therefore, the aim of the study was that patients contribute and prioritize clinically relevant outcomes to a systematic review on meta-cognitive interventions, and to evaluate a patient workshop as well as patients' perceptions of research involvement. Seven patients with experience in psychiatric care participated in our workshop. They focused on outcomes pre-defined in the review protocol (e.g., meta-cognitive or cognitive changes, symptomatology, quality of life), neglected other outcomes (like satisfaction with treatment, acceptability), and added relevant new ones (e.g., scope of action/autonomy, applicability). Altogether, they valued the explicit workshop participation positively. However, some suggested to involve patients at an earlier stage and to adapt the amount of information given. Further systematic reviews would benefit from the involvement of patients in the definition of other components of the review question (like patients or interventions), in the interpretation of key findings or in drafting a lay summary.}, language = {en} } @article{TabbenIhsanGhouletal.2018, author = {Tabben, Montassar and Ihsan, Mohammed and Ghoul, Nihel and Coquart, Jeremy and Chaouachi, Anis and Chaabene, Helmi and Tourny, Claire and Chamari, Karim}, title = {Performance 24-h After a Simulated Mixed Martial Arts Combat}, series = {Frontiers in physiology}, volume = {9}, journal = {Frontiers in physiology}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1664-042X}, doi = {10.3389/fphys.2018.01542}, pages = {8}, year = {2018}, abstract = {Objective: The aim of the present study was to examine the effect of Cold Water Immersion (CWI) on the recovery of physical performance, hematological stress markers and perceived wellness (i.e., Hooper scores) following a simulated Mixed Martial Arts (MMA) competition. Methods: Participants completed two experimental sessions in a counter-balanced order (CWI or passive recovery for control condition: CON), after a simulated MMAs competition (3 x 5-min MMA rounds separated by 1-min of passive rest). During CWI, athletes were required to submerge their bodies, except the trunk, neck and head, in the seated position in a temperature-controlled bath (similar to 10 degrees C) for 15-min. During CON, athletes were required to be in a seated position for 15-min in same room ambient temperature. Venous blood samples (creatine kinase, cortisol, and testosterone concentrations) were collected at rest (PRE-EX, i.e., before MMAs), immediately following MMAs (POST-EX), immediately following recovery (POST-R) and 24 h post MMAs (POST-24), whilst physical fitness (squat jump, countermovement-jump and 5- and 10-m sprints) and perceptual measures (well-being Hooper index: fatigue, stress, delayed onset muscle soreness (DOMS), and sleep) were collected at PRE-EX, POST-R and POST-24, and at PRE-EX and POST-24, respectively. Conclusion: The use of CWI resulted in an enhanced recovery of 10-m sprint performance, as well as improved perceived wellness 24-h following simulated MMA competition.}, language = {en} } @article{GerberEhrbarBrandetal.2018, author = {Gerber, Markus and Ehrbar, Janine and Brand, Ralf and Antoniewicz, Franziska and Brand, Serge and Colledge, Flora and Donath, Lars and Egger, Stephan T. and Hatzinger, Martin and Holsboer-Trachsler, Edith and Imboden, Christian and Schweinfurth, Nina and Vetter, Stefan and Ludyga, Sebastian}, title = {Implicit attitudes towards exercise and physical activity behaviour among in-patients with psychiatric disorders}, series = {Mental Health and Physical Activity}, volume = {15}, journal = {Mental Health and Physical Activity}, publisher = {Elsevier}, address = {Oxford}, issn = {1755-2966}, doi = {10.1016/j.mhpa.2018.08.001}, pages = {71 -- 77}, year = {2018}, abstract = {The current body of evidence suggests that in healthy participants, implicit attitudes towards physical activity explain variance in exercise behaviour beyond explicit cognitive processes. However, such relationships have not been examined in psychiatric patients, although this may contribute to a better understanding of the motivational and volitional resources needed to self-regulate their exercise behaviour. Therefore, the present cross-sectional study aimed to assess implicit attitudes towards exercise among psychiatric in-patients, and to correlate these implicit attitudes with their physical activity levels. Patients (N = 101) showing a psychiatric disorder, but no severe cognitive impairment, were directly recruited from psychiatric clinics. Their physical activity levels were assessed using both accelerometers and self-reports. Additionally, patients reported psychiatric symptoms and performed a single-target implicit association test (ST-IAT) with exercise employed as the target category. Of all patients, 39\% showed a preference for exercise, whereas 13\% showed an aversion towards exercise. The implicit attitudes of the remaining participants were equally strong for both concepts. Based on correlational analysis (correcting for age, sex, psychiatric symptoms severity, and ST-IAT sequence), no association was found between ST-IAT score, or self-reported and objectively assessed physical activity. Consequently, the link between exercise behaviour and implicit attitudes towards physical activity found in healthy participants could not be observed in psychiatric patients.}, language = {en} } @article{KlattNoelMusculusetal.2019, author = {Klatt, Stefanie and Noel, Benjamin and Musculus, Lisa and Werner, Karsten and Laborde, Sylvain and Lopes, Mariana Calabria and Greco, Pablo J. and Memmert, Daniel and Raab, Markus}, title = {Creative and Intuitive Decision-Making Processes: A Comparison of Brazilian and German Soccer Coaches and Players}, series = {Research Quarterly for Exercise and Sport}, volume = {90}, journal = {Research Quarterly for Exercise and Sport}, number = {4}, publisher = {Routledge, Taylor \& Francis Group}, address = {Abingdon}, issn = {0270-1367}, doi = {10.1080/02701367.2019.1642994}, pages = {651 -- 665}, year = {2019}, abstract = {Purpose: The concepts of creativity and intuition have been well studied in isolation, but less is known about their distinctive contributions to option generation in decision making. Method: We examined the relation between creative and intuitive decision making in two studies-one involving coaches and one involving soccer players-using video footage of real soccer matches. Additionally, we analyzed whether this relation is culture generic or culture specific by conducting matched cross-cultural studies in a European and a South American country. Results: In Study 1, results indicate a conceptual overlap of creativity and intuition for Brazilian and German soccer coaches. Furthermore, coaches did not differ in their evaluation of creative and intuitive actions of players of both cultures. In Study 2, we found that for both subsamples the total number of generated options was positively correlated with the quality of the first and the final option and that the quality of players' first (intuitive) option was higher than that of options generated later. Moreover, results indicate a positive correlation between a player's creativity score and the quality of the first generated option for the whole sample. Conclusion: Overall, our findings provide meaningful information regarding athletes' and coaches' option-generation processes in decision making in complex team sports.}, language = {en} } @article{LoepfeDussZafeiropoulouetal.2019, author = {L{\"o}pfe, Moira and Duss, Anja and Zafeiropoulou, Katerina-Alexandra and Bjoergvinsdottir, Oddny and Eglin, David and Fortunato, Giuseppino and Klasen, J{\"u}rgen and Ferguson, Stephen J. and W{\"u}rtz-Kozak, Karin and Krupkova, Olga}, title = {Electrospray-Based Microencapsulation of Epigallocatechin 3-Gallate for Local Delivery into the Intervertebral Disc}, series = {Pharmaceutics}, volume = {11}, journal = {Pharmaceutics}, number = {9}, publisher = {MDPI}, address = {Basel}, issn = {1999-4923}, doi = {10.3390/pharmaceutics11090435}, pages = {15}, year = {2019}, abstract = {Locally delivered anti-inflammatory compounds can restore the homeostasis of the degenerated intervertebral disc (IVD). With beneficial effects on IVD cells, epigallocatechin 3-gallate (EGCG) is a promising therapeutic candidate. However, EGCG is prone to rapid degradation and/or depletion. Therefore, the purpose of this study was to develop a method for controlled EGCG delivery in the degenerated IVD. Primary IVD cells were isolated from human donors undergoing IVD surgeries. EGCG was encapsulated into microparticles by electrospraying of glutaraldehyde-crosslinked gelatin. The resulting particles were characterized in terms of cytocompatibility and anti-inflammatory activity, and combined with a thermoresponsive carrier to produce an injectable EGCG delivery system. Subsequently, electrospraying was scaled up using the industrial NANOSPIDER (TM) technology. The produced EGCG microparticles reduced the expression of inflammatory (IL-6, IL-8, COX-2) and catabolic (MMP1, MMP3, MMP13) mediators in pro-inflammatory 3D cell cultures. Combining the EGCG microparticles with the carrier showed a trend towards modulating EGCG activity/release. Electrospray upscaling was achieved, leading to particles with homogenous spherical morphologies. In conclusion, electrospray-based encapsulation of EGCG resulted in cytocompatible microparticles that preserved the activity of EGCG and showed the potential to control EGCG release, thus favoring IVD health by downregulating local inflammation. Future studies will focus on further exploring the biological activity of the developed delivery system for potential clinical use.}, language = {en} } @article{AlgharablyBolbrinkerLeziusetal.2017, author = {Algharably, Engi A. H. and Bolbrinker, Juliane and Lezius, Susanne and Reibis, Rona Katharina and Wegscheider, Karl and V{\"o}ller, Heinz and Kreutz, Reinhold}, title = {Uromodulin associates with cardiorenal function in patients with hypertension and cardiovascular disease}, series = {Journal of hypertension}, volume = {35}, journal = {Journal of hypertension}, publisher = {Lippincott Williams \& Wilkins}, address = {Philadelphia}, issn = {0263-6352}, doi = {10.1097/HJH.0000000000001432}, pages = {2053 -- 2058}, year = {2017}, abstract = {Objective:Common genetic variants in the gene encoding uromodulin (UMOD) have been associated with renal function, blood pressure (BP) and hypertension. We investigated the associations between an important single nucleotide polymorphism (SNP) in UMOD, that is rs12917707-G>T, and estimated glomerular filtration rate (eGFR), BP and cardiac organ damage as determined by echocardiography in patients with arterial hypertension.Methods:A cohort of 1218 treated high-risk patients (mean age 58.5 years, 83\% men) with documented cardiovascular disease (81\% with coronary heart disease) was analysed.Results:The mean values for 24-h SBP and DBP were 124.714.7 and 73.9 +/- 9.4mmHg; mean eGFR was 77.5 +/- 18.3ml/min per 1.73m(2), mean left ventricular ejection fraction was 59.3 +/- 9.9\% and mean left ventricular mass index in men and women was 53.9 +/- 23.2 and 54.9 +/- 23.7g/m(2.7) with 50.4\% of patients having left ventricular hypertrophy. A significant association between rs12917707 and eGFR was observed with T-allele carriers showing significantly higher eGFR values (+2.6ml/min per 1.73m(2), P=0.006) than noncarriers. This SNP associated also with left atrial diameter (P=0.007); homozygous carriers of the T-allele had smaller left atrial diameter (-1.5mm) than other genotype groups (P=0.040). No significant associations between rs12917707 and other cardiac or BP phenotypes were observed.Conclusions:These findings extend the previously documented role of UMOD for renal function also to treated high-risk patients with arterial hypertension and reveal a novel association with left atrial remodelling and thus a potential cardiorenal link modulated by UMOD.}, language = {en} } @article{SixtusFischerLindemann2017, author = {Sixtus, Elena and Fischer, Martin H. and Lindemann, Oliver}, title = {Finger posing primes number comprehension}, series = {Cognitive processing : international quarterly of cognitive science}, volume = {18}, journal = {Cognitive processing : international quarterly of cognitive science}, publisher = {Springer}, address = {Heidelberg}, issn = {1612-4782}, doi = {10.1007/s10339-017-0804-y}, pages = {237 -- 248}, year = {2017}, abstract = {Canonical finger postures, as used in counting, activate number knowledge, but the exact mechanism for this priming effect is unclear. Here we dissociated effects of visual versus motor priming of number concepts. In Experiment 1, participants were exposed either to pictures of canonical finger postures (visual priming) or actively produced the same finger postures (motor priming) and then used foot responses to rapidly classify auditory numbers (targets) as smaller or larger than 5. Classification times revealed that manually adopted but not visually perceived postures primed magnitude classifications. Experiment 2 obtained motor priming of number processing through finger postures also with vocal responses. Priming only occurred through canonical and not through non-canonical finger postures. Together, these results provide clear evidence for motor priming of number knowledge. Relative contributions of vision and action for embodied numerical cognition and the importance of canonicity of postures are discussed.}, language = {en} } @article{HuangGuoYangetal.2017, author = {Huang, Hongshi and Guo, Jianqiao and Yang, Jie and Jiang, Yanfang and Yu, Yuanyuan and Mueller, Steffen and Ren, Gexue and Ao, Yingfang}, title = {Isokinetic angle-specific moments and ratios characterizing hamstring and quadriceps strength in anterior cruciate ligament deficient knees}, series = {Scientific reports}, volume = {7}, journal = {Scientific reports}, publisher = {Nature Publ. Group}, address = {London}, issn = {2045-2322}, doi = {10.1038/s41598-017-06601-5}, pages = {11}, year = {2017}, abstract = {This study is intended to find more effective and robust clinical diagnostic indices to characterize muscle strength and coordination alternation following anterior cruciate ligament (ACL) rupture. To evaluate angle-specific moments and hamstring (H)/quadriceps (Q) ratios, 46 male subjects with unilateral chronic ACL-rupture performed isokinetic concentric (c), eccentric (e) quadriceps and hamstring muscle tests respectively at 60 degrees/s. Normalized moments and H/Q ratios were calculated for peak moment (PM) and 30 degrees, 40 degrees, 50 degrees, 60 degrees, 70 degrees, 80 degrees knee flexion angles. Furthermore, we introduced single-to-arithmetic-mean (SAM) and single-to-root-mean-square (SRMS) muscle co-contraction ratios, calculating them for specific angles and different contraction repetitions. Normalized PM and 40 degrees specific concentric quadriceps, concentric hamstring strength in the ACL-deficient knee were reduced significantly (P <= 0.05). Concentric angle-specific moments together with Qe/Qc ratios at 40 degrees (d = 0.766 vs. d = 0.654) identify more obvious differences than peak values in ACL ruptured limbs. Furthermore, we found SRMS-QeQc deficits at 40 degrees showed stronger effect than Qe/Qc ratios (d = 0.918 vs. d = 0.766), albeit other ratio differences remained basically the same effect size as the original H/Q ratios. All the newly defined SAM and SRMS indices could decrease variance. Overall, 40 degrees knee moments and SAM/ SRMS ratios might be new potential diagnosis indices for ACL rupture detection.}, language = {en} } @article{SalzwedelReibisHeidleretal.2019, author = {Salzwedel, Annett and Reibis, Rona Katharina and Heidler, Maria-Dorothea and Wegscheider, Karl and V{\"o}ller, Heinz}, title = {Determinants of Return to Work After Multicomponent Cardiac Rehabilitation}, series = {Archives of Physical Medicine and Rehabilitation}, volume = {100}, journal = {Archives of Physical Medicine and Rehabilitation}, number = {12}, publisher = {Elsevier}, address = {Philadelphia}, issn = {0003-9993}, doi = {10.1016/j.apmr.2019.04.003}, pages = {2399 -- 2402}, year = {2019}, abstract = {Objectives: To explore predictors of return to work in patients after acute coronary syndrome and coronary artery bypass grafting, taking into account cognitive performance, depression, physical capacity, and self-assessment of the occupational prognosis. Design: Observational, prospective, bicentric. Setting: Postacute 3-week inpatient cardiac rehabilitation (CR). Participants: Patients (N=401) <65 years of age (mean 54.5 +/- 6.3y), 80\% men. Interventions: Not applicable. Main Outcome Measures: Status of return to work (RTW) 6 months after discharge from CR. Results: The regression model for RTW showed negative associations for depression (odds ratio 0.52 per SD, 95\% confidence interval 0.36-0.76, P=.001), age (odds ratio 0.72, 95\% confidence interval 0.52-1.00, P=.047), and in particular for a negative subjective occupational prognosis (expected incapacity for work odds ratio 0.19, 95\% confidence interval 0.06-0.59, P=.004; unemployment odds ratio 0.08, 95\% confidence interval 0.01-0.72, P=.024; retirement odds ratio 0.07, 95\% confidence interval 0.01-0.067, P=.021). Positive predictors were employment before the cardiac event (odds ratio 9.66, 95\% confidence interval 3.10-30.12, P<.001), capacity to work (fit vs unfit) at discharge from CR (odds ratio 3.15, 95\% confidence interval 1.35-7.35, P=.008), and maximum exercise capacity (odds ratio 1.49, 95\% confidence interval 1.06-2.11, P=.022). Cognitive performance had no effect.}, language = {en} } @misc{SalzwedelVoellerReibis2019, author = {Salzwedel, Annett and V{\"o}ller, Heinz and Reibis, Rona Katharina}, title = {Vocational reintegration in coronary heart disease patients - the holistic approach of the WHO biopsychosocial concept}, series = {European journal of preventive cardiology : the official ESC journal for primary \& secondary cardiovascular prevention, rehabilitation and sports cardiology}, volume = {26}, journal = {European journal of preventive cardiology : the official ESC journal for primary \& secondary cardiovascular prevention, rehabilitation and sports cardiology}, number = {13}, publisher = {Sage Publ.}, address = {London}, issn = {2047-4873}, doi = {10.1177/2047487319850699}, pages = {1383 -- 1385}, year = {2019}, language = {en} } @article{SchuchStubbsMeyeretal.2019, author = {Schuch, Felipe B. and Stubbs, Brendon and Meyer, Jacob and Heissel, Andreas and Zech, Philipp and Vancampfort, Davy and Rosenbaum, Simon and Deenik, Jeroen and Firth, Joseph and Ward, Philip B. and Carvalho, Andre F. and Hiles, Sarah A.}, title = {Physical activity protects from incident anxiety: A meta-analysis of prospective cohort studies}, series = {Depression and anxiety}, volume = {36}, journal = {Depression and anxiety}, number = {9}, publisher = {Wiley}, address = {Hoboken}, issn = {1091-4269}, doi = {10.1002/da.22915}, pages = {846 -- 858}, year = {2019}, abstract = {Background Prospective cohorts have suggested that physical activity (PA) can decrease the risk of incident anxiety. However, no meta-analysis has been conducted. Aims To examine the prospective relationship between PA and incident anxiety and explore potential moderators. Methods Searches were conducted on major databases from inception to October 10, 2018 for prospective studies (at least 1 year of follow-up) that calculated the odds ratio (OR) of incident anxiety in people with high PA against people with low PA. Methodological quality was assessed using the Newcastle-Ottawa Scale (NOS). A random-effects meta-analysis was conducted and heterogeneity was explored using subgroup and meta-regression analysis. Results Across 14 cohorts of 13 unique prospective studies (N = 75,831, median males = 50.1\%) followed for 357,424 person-years, people with high self-reported PA (versus low PA) were at reduced odds of developing anxiety (adjusted odds ratio [AOR] = 0.74; 95\% confidence level [95\% CI] = 0.62, 0.88; crude OR = 0.80; 95\% CI = 0.69, 0.92). High self-reported PA was protective against the emergence of agoraphobia (AOR = 0.42; 95\% CI = 0.18, 0.98) and posttraumatic stress disorder (AOR = 0.57; 95\% CI = 0.39, 0.85). The protective effects for anxiety were evident in Asia (AOR = 0.31; 95\% CI = 0.10, 0.96) and Europe (AOR = 0.82; 95\% CI = 0.69, 0.97); for children/adolescents (AOR = 0.52; 95\% CI = 0.29, 0.90) and adults (AOR = 0.81; 95\% CI = 0.69, 0.95). Results remained robust when adjusting for confounding factors. Overall study quality was moderate to high (mean NOS = 6.7 out of 9). Conclusion Evidence supports the notion that self-reported PA can confer protection against the emergence of anxiety regardless of demographic factors. In particular, higher PA levels protects from agoraphobia and posttraumatic disorder.}, language = {en} } @article{VoellerHeyne2020, author = {V{\"o}ller, Heinz and Heyne, Karen}, title = {Evaluation of the Accuracy of the LumiraDx INR Test Using Patients in Receipt of Phenprocoumon Anticoagulation Therapy}, series = {Point of care : the journal of near-patient testing \& technology}, volume = {19}, journal = {Point of care : the journal of near-patient testing \& technology}, number = {3}, publisher = {Lippincott Williams \& Wilkins}, address = {Philadelphia}, issn = {1533-029X}, doi = {10.1097/POC.0000000000000207}, pages = {72 -- 76}, year = {2020}, abstract = {Background: The LumiraDx INR Test is a new point-of-care diagnostic test designed to analyze fingerstick blood samples. The test was assessed in patients receiving phenprocoumon (NCT04074980). Methods: Venous plasma international normalized ratio (INR) was measured using the LumiraDx INR Test. LumiraDx INR Test-ascertained capillary whole blood INR was compared with venous plasma INR measured using the IL ACL Elite Pro and Sysmex CS-5100 reference instruments. Results: A total of 102 patients receiving phenprocoumon were recruited. The INR results from venous plasma and capillary whole blood that were analyzed on the LumiraDx INR Test correlated well with those measured using the IL ACL Elite Pro (plasma: n = 25, r = 0.981; capillary blood: n = 74, r = 0.949) and the Sysmex CS-5100 (n = 73, r = 0.950). Conclusions: The LumiraDx INR Test showed high accuracy in analyzing venous plasma and capillary whole blood from patients receiving phenprocoumon.}, language = {en} } @article{GrajaGarciaCarrizoJanketal.2018, author = {Graja, Antonia and Garcia-Carrizo, Francisco and Jank, Anne-Marie and Gohlke, Sabrina and Ambrosi, Thomas H. and Jonas, Wenke and Ussar, Siegfried and Kern, Matthias and Sch{\"u}rmann, Annette and Aleksandrova, Krasimira and Bluher, Matthias and Schulz, Tim Julius}, title = {Loss of periostin occurs in aging adipose tissue of mice and its genetic ablation impairs adipose tissue lipid metabolism}, series = {Aging Cell}, volume = {17}, journal = {Aging Cell}, number = {5}, publisher = {Wiley}, address = {Hoboken}, issn = {1474-9718}, doi = {10.1111/acel.12810}, pages = {13}, year = {2018}, abstract = {Remodeling of the extracellular matrix is a key component of the metabolic adaptations of adipose tissue in response to dietary and physiological challenges. Disruption of its integrity is a well-known aspect of adipose tissue dysfunction, for instance, during aging and obesity. Adipocyte regeneration from a tissue-resident pool of mesenchymal stem cells is part of normal tissue homeostasis. Among the pathophysiological consequences of adipogenic stem cell aging, characteristic changes in the secretory phenotype, which includes matrix-modifying proteins, have been described. Here, we show that the expression of the matricellular protein periostin, a component of the extracellular matrix produced and secreted by adipose tissue-resident interstitial cells, is markedly decreased in aged brown and white adipose tissue depots. Using a mouse model, we demonstrate that the adaptation of adipose tissue to adrenergic stimulation and high-fat diet feeding is impaired in animals with systemic ablation of the gene encoding for periostin. Our data suggest that loss of periostin attenuates lipid metabolism in adipose tissue, thus recapitulating one aspect of age-related metabolic dysfunction. In human white adipose tissue, periostin expression showed an unexpected positive correlation with age of study participants. This correlation, however, was no longer evident after adjusting for BMI or plasma lipid and liver function biomarkers. These findings taken together suggest that age-related alterations of the adipose tissue extracellular matrix may contribute to the development of metabolic disease by negatively affecting nutrient homeostasis.}, language = {en} } @misc{KrupkovaSmoldersWuertzKozaketal.2018, author = {Krupkova, Olga and Smolders, Lucas and W{\"u}rtz-Kozak, Karin and Cook, James and Pozzi, Antonio}, title = {The pathobiology of the meniscus}, series = {Frontiers in veterinary science}, volume = {5}, journal = {Frontiers in veterinary science}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {2297-1769}, doi = {10.3389/fvets.2018.00073}, pages = {15}, year = {2018}, abstract = {Serious knee pain and related disability have an annual prevalence of approximately 25\% on those over the age of 55 years. As curative treatments for the common knee problems are not available to date, knee pathologies typically progress and often lead to osteoarthritis (OA). While the roles that the meniscus plays in knee biomechanics are well characterized, biological mechanisms underlying meniscus pathophysiology and roles in knee pain and OA progression are not fully clear. Experimental treatments for knee disorders that are successful in animal models often produce unsatisfactory results in humans due to species differences or the inability to fully replicate disease progression in experimental animals. The use of animals with spontaneous knee pathologies, such as dogs, can significantly help addressing this issue. As microscopic and macroscopic anatomy of the canine and human menisci are similar, spontaneous meniscal pathologies in canine patients are thought to be highly relevant for translational medicine. However, it is not clear whether the biomolecular mechanisms of pain, degradation of extracellular matrix, and inflammatory responses are species dependent. The aims of this review are (1) to provide an overview of the anatomy, physiology, and pathology of the human and canine meniscus, (2) to compare the known signaling pathways involved in spontaneous meniscus pathology between both species, and (3) to assess the relevance of dogs with spontaneous meniscal pathology as a translational model. Understanding these mechanisms in human and canine meniscus can help to advance diagnostic and therapeutic strategies for painful knee disorders and improve clinical decision making.}, language = {en} } @article{SadowskaKamedaKrupkovaetal.2018, author = {Sadowska, Aleksandra and Kameda, Takuya and Krupkova, Olga and Wuertz-Kozak, Karin}, title = {Osmosensing, osmosignalling and inflammation}, series = {European cells \& materials}, volume = {36}, journal = {European cells \& materials}, publisher = {Ao research institute davos-Ari}, address = {Davos}, issn = {1473-2262}, doi = {10.22203/eCM.v036a17}, pages = {231 -- 250}, year = {2018}, abstract = {Intervertebral disc (IVD) cells are naturally exposed to high osmolarity and complex mechanical loading, which drive microenvironmental osmotic changes. Age- and degeneration-induced degradation of the IVD's extracellular matrix causes osmotic imbalance, which, together with an altered function of cellular receptors and signalling pathways, instigates local osmotic stress. Cellular responses to osmotic stress include osmoadaptation and activation of pro-inflammatory pathways. This review summarises the current knowledge on how IVD cells sense local osmotic changes and translate these signals into physiological or pathophysiological responses, with a focus on inflammation. Furthermore, it discusses the expression and function of putative membrane osmosensors (e.g. solute carrier transporters, transient receptor potential channels, aquaporins and acid-sensing ion channels) and osmosignalling mediators [e.g. tonicity response-element-binding protein/nuclear factor of activated T-cells 5 (TonEBP/NFAT5), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB)] in healthy and degenerated IVDs. Finally, an overview of the potential therapeutic targets for modifying osmosensing and osmosignalling in degenerated IVDs is provided.}, language = {en} } @article{MartinezValdesNegroFallaetal.2018, author = {Martinez-Valdes, Eduardo Andr{\´e}s and Negro, Francesco and Falla, Deborah and De Nunzio, Alessandro Marco and Farina, Dario}, title = {Surface electromyographic amplitude does not identify differences in neural drive to synergistic muscles}, series = {Journal of applied physiology}, volume = {124}, journal = {Journal of applied physiology}, number = {4}, publisher = {American Chemical Society}, address = {Bethesda}, issn = {8750-7587}, doi = {10.1152/japplphysiol.01115.2017}, pages = {1071 -- 1079}, year = {2018}, abstract = {Surface electromyographic (EMG) signal amplitude is typically used to compare the neural drive to muscles. We experimentally investigated this association by studying the motor unit (MU) behavior and action potentials in the vastus medialis (VM) and vastus lateralis (VL) muscles. Eighteen participants performed isometric knee extensions at four target torques [10. 30. 50, and 70\% of the maximum torque (MVC)] while high-density EMG signals were recorded from the VM and VL. The absolute EMG amplitude was greater for VM than VL (P < 0.001), whereas the EMG amplitude normalized with respect to MVC was greater for VL than VM (P < 0.04). Because differences in EMG amplitude can be due to both differences in the neural drive and in the size of the MU action potentials, we indirectly inferred the neural drives received by the two muscles by estimating the synaptic inputs received by the corresponding motor neuron pools. For this purpose. we analyzed the increase in discharge rate from recruitment to target torque for motor units matched by recruitment threshold in the two muscles. This analysis indicated that the two muscles received similar levels of neural drive. Nonetheless, the size of the MU action potentials was greater for VM than VL (P < 0.001), and this difference explained most of the differences in EMG amplitude between the two muscles (similar to 63\% of explained variance). These results indicate that EMG amplitude, even following normalization, does not reflect the neural drive to synergistic muscles. Moreover, absolute EMG amplitude is mainly explained by the size of MU action potentials. NEW \& NOTEWORTHY Electromyographic (EMG) amplitude is widely used to compare indirectly the strength of neural drive received by synergistic muscles. However, there are no studies validating this approach with motor unit data. Here, we compared between-muscles differences in surface EMG amplitude and motor unit behavior. The results clarify the limitations of surface EMG to interpret differences in neural drive between muscles.}, language = {en} } @article{EichlerSalzwedelHarnathetal.2018, author = {Eichler, Sarah and Salzwedel, Annett and Harnath, Axel and Butter, Christian and Wegscheider, Karl and Chiorean, Mihai and V{\"o}ller, Heinz and Reibis, Rona Katharina}, title = {Nutrition and mobility predict all-cause mortality in patients 12 months after transcatheter aortic valve implantation}, series = {Clinical research in cardiology : official journal of the German Cardiac Society.}, volume = {107}, journal = {Clinical research in cardiology : official journal of the German Cardiac Society.}, number = {4}, publisher = {Springer}, address = {Heidelberg}, issn = {1861-0684}, doi = {10.1007/s00392-017-1183-1}, pages = {304 -- 311}, year = {2018}, abstract = {The aim of the study was to determine pre-interventional predictors for all-cause mortality in patients after transcatheter aortic valve implantation (TAVI) with a 12-month follow-up. From 10/2013 to 07/2015, 344 patients (80.9 +/- 5.0 years, 44.5\% male) with an elective TAVI were consecutively enrolled prospectively in a multicentre cohort study. Prior to the intervention, sociodemographic parameters, echocardiographic data and comorbidities were documented. All patients performed a 6-min walk test, Short Form 12 and a Frailty Index (score consisting of activities of daily living, cognition, nutrition and mobility). Peri-interventional complications were documented. Vital status was assessed over telephone 12 months after TAVI. Predictors for all-cause mortality were identified using a multivariate regression model. At discharge, 333 patients were alive (in-hospital mortality 3.2\%; n = 11). During a follow-up of 381.0 +/- 41.9 days, 46 patients (13.8\%) died. The non-survivors were older (82.3 +/- 5.0 vs. 80.6 +/- 5.1 years; p = 0.035), had a higher number of comorbidities (2.6 +/- 1.3 vs. 2.1 +/- 1.3; p = 0.026) and a lower left ventricular ejection fraction (51.0 +/- 13.6 vs. 54.6 +/- 10.6\%; p = 0.048). Additionally, more suffered from diabetes mellitus (60.9 vs. 44.6\%; p = 0.040). While the global Frailty Index had no predictive power, its individual components, particularly nutrition (OR 0.83 per 1 pt., CI 0.72-0.95; p = 0.006) and mobility (OR 5.12, CI 1.64-16.01; p = 0.005) had a prognostic impact. Likewise, diabetes mellitus (OR 2.18, CI 1.10-4.32; p = 0.026) and EuroSCORE (OR 1.21 per 5\%, CI 1.07-1.36; p = 0.002) were associated with a higher risk of all-cause mortality. Besides EuroSCORE and diabetes mellitus, nutrition status and mobility of patients scheduled for TAVI offer prognostic information for 1-year all-cause mortality and should be advocated in the creation of contemporary TAVI risk scores.}, language = {en} } @misc{BridwellCavanaghCollinsetal.2018, author = {Bridwell, David A. and Cavanagh, James F. and Collins, Anne G. E. and Nunez, Michael D. and Srinivasan, Ramesh and Stober, Sebastian and Calhoun, Vince D.}, title = {Moving Beyond ERP Components}, series = {Frontiers in human neuroscienc}, volume = {12}, journal = {Frontiers in human neuroscienc}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1662-5161}, doi = {10.3389/fnhum.2018.00106}, pages = {17}, year = {2018}, abstract = {Relationships between neuroimaging measures and behavior provide important clues about brain function and cognition in healthy and clinical populations. While electroencephalography (EEG) provides a portable, low cost measure of brain dynamics, it has been somewhat underrepresented in the emerging field of model-based inference. We seek to address this gap in this article by highlighting the utility of linking EEG and behavior, with an emphasis on approaches for EEG analysis that move beyond focusing on peaks or "components" derived from averaging EEG responses across trials and subjects (generating the event-related potential, ERP). First, we review methods for deriving features from EEG in order to enhance the signal within single-trials. These methods include filtering based on user-defined features (i.e., frequency decomposition, time-frequency decomposition), filtering based on data-driven properties (i.e., blind source separation, BSS), and generating more abstract representations of data (e.g., using deep learning). We then review cognitive models which extract latent variables from experimental tasks, including the drift diffusion model (DDM) and reinforcement learning (RL) approaches. Next, we discuss ways to access associations among these measures, including statistical models, data-driven joint models and cognitive joint modeling using hierarchical Bayesian models (HBMs). We think that these methodological tools are likely to contribute to theoretical advancements, and will help inform our understandings of brain dynamics that contribute to moment-to-moment cognitive function.}, language = {en} } @article{SadowskaTouliHitzletal.2017, author = {Sadowska, Aleksandra and Touli, Ermioni and Hitzl, Wolfgang and Greutert, Helen and Ferguson, Stephen J. and W{\"u}rtz-Kozak, Karin and Hausmann, Oliver N.}, title = {Inflammaging in cervical and lumbar degenerated intervertebral discs}, series = {European Spine Journal}, volume = {27}, journal = {European Spine Journal}, number = {3}, publisher = {Springer}, address = {New York}, issn = {0940-6719}, doi = {10.1007/s00586-017-5360-8}, pages = {564 -- 577}, year = {2017}, abstract = {To investigate and compare the occurrence of inflammatory processes in the sites of disc degeneration in the lumbar and cervical spine by a gene array and subsequent qPCR and to investigate the mechanistic involvement of transient receptor potential channels TRPC6 and TRPV4. The gene expression of inflammatory cytokines and TRP channels was measured in human disc samples obtained from patients undergoing discectomy at the cervical (n = 24) or lumbar (n = 27) spine for degenerative disc disease (DDD) and disc herniation (DH) and analyzed for differences with regard to spinal level, IVD degeneration grade, Modic grade, age, sex, disc region and surgical extent. Aside from genes with known implication in DDD and DH, four previously unreported genes from the interferon and TRP families (IFNA1, IFNA8, IFNB1, TRPC6) could be detected. A correlation between gene expression and age (IL-15) and IVD degeneration grade (IFNA1, IL-6, IL-15, TRPC6), but not Modic grade, was identified. Significant differences were detected between cervical and lumbar discs (IL-15), nucleus and annulus (IL-6, TNF-alpha, TRPC6), single-level and multi-level surgery (IL-6, IL-8) as well as DDD and DH (IL-8), while sex had no effect. Multiple gene-gene pair correlations, either between different cytokines or between cytokines and TRP channels, exist in the disc. This study supports the relevance of IL-6 and IL-8 in disc diseases, but furthermore points toward a possible pathological role of IL-15 and type I interferons, as well as a mechanistic role of TRPC6. With limited differences in the inflammatory profile of cervical and lumbar discs, novel anti-inflammatory or TRP-modulatory strategies for the treatment of disc pathologies may be applicable independent of the spinal region.}, language = {en} } @misc{KhajooeiLinSteffanetal.2018, author = {Khajooei, Mina and Lin, Chiao-I and Steffan, M{\"u}ller and Mayer, Frank}, title = {Effect of Instability in Legpress Testing on Strength \& Muscle Activity in Functional Ankle Instability}, series = {Medicine and science in sports and exercise : official journal of the American College of Sports Medicine}, volume = {50}, journal = {Medicine and science in sports and exercise : official journal of the American College of Sports Medicine}, number = {5S}, publisher = {Lippincott Williams \& Wilkins}, address = {Philadelphia}, issn = {0195-9131}, doi = {:10.1249/01.mss.0000537073.01736.db}, pages = {602 -- 602}, year = {2018}, language = {en} } @article{OuerguiDelleliBouassidaetal.2021, author = {Ouergui, Ibrahim and Delleli, Slaheddine and Bouassida, Anissa and Bouhlel, Ezdine and Chaabene, Helmi and Ardig{\`o}, Luca Paolo and Franchini, Emerson}, title = {Technical-tactical analysis of small combat games in male kickboxers}, series = {BMC Sports Science, Medicine and Rehabilitation}, journal = {BMC Sports Science, Medicine and Rehabilitation}, number = {13}, publisher = {Springer Nature}, address = {Berlin}, issn = {2052-1847}, doi = {10.1186/s13102-021-00391-0}, pages = {8}, year = {2021}, abstract = {Background: To handle the competition demands, sparring drills are used for specific technical-tactical training as well as physical-physiological conditioning in combat sports. While the effects of different area sizes and number of within-round sparring partners on physiological and perceptive responses in combats sports were examined in previous studies, technical and tactical aspects were not investigated. This study investigated the effect of different within-round sparring partners number (i.e., at a time; 1 vs. 1, 1 vs. 2, and 1 vs. 4) and area sizes (2 m × 2 m, 4 m × 4 m, and 6 m × 6 m) variation on the technical-tactical aspects of small combat games in kickboxing. Method: Twenty male kickboxers (mean ± standard deviation, age: 20.3 ± 0.9 years), regularly competing in regional and national events randomly performed nine different kickboxing combats, lasting 2 min each. All combats were video recorded and analyzed using the software Dartfish. Results: Results showed that the total number of punches was significantly higher in 1 versus 4 compared with 1 versus 1 (p = 0.011, d = 0.83). Further, the total number of kicks was significantly higher in 1 versus 4 compared with 1 versus 1 and 1 versus 2 (p < 0.001; d = 0.99 and d = 0.83, respectively). Moreover, the total number of kick combinations was significantly higher in 1 versus 4 compared with 1 versus 1 and 1 versus 2 (p < 0.001; d = 1.05 and d = 0.95, respectively). The same outcome was significantly lower in 2 m × 2 m compared with 4 m × 4 m and 6 m × 6 m areas (p = 0.010 and d = - 0.45; p < 0.001 and d = - 0.6, respectively). The number of block-and-parry was significantly higher in 1 versus 4 compared with 1 versus 1 (p < 0.001, d = 1.45) and 1 versus 2 (p = 0.046, d = 0.61) and in 2 m × 2 m compared with 4 m × 4 m and 6 × 6 m areas (p < 0.001; d = 0.47 and d = 0.66, respectively). Backwards lean actions occurred more often in 2 m × 2 m compared with 4 m × 4 m (p = 0.009, d = 0.53) and 6 m × 6 m (p = 0.003, d = 0.60). However, the number of foot defenses was significantly lower in 2 m × 2 m compared with 6 m × 6 m (p < 0.001, d = 1.04) and 4 m × 4 m (p = 0.004, d = 0.63). Additionally, the number of clinches was significantly higher in 1 versus 1 compared with 1 versus 2 (p = 0.002, d = 0.7) and 1 versus 4 (p = 0.034, d = 0.45). Conclusions: This study provides practical insights into how to manipulate within-round sparring partners' number and/or area size to train specific kickboxing technical-tactical fundamentals.}, language = {en} } @article{BisiBalogunRector2017, author = {Bisi-Balogun, Adebisi and Rector, Michael V.}, title = {Clinical Utility of Ultrasound Measurements of Plantar Fascia Width and Cross-Sectional Area}, series = {Journal of the American Podiatric Medical Association}, volume = {107}, journal = {Journal of the American Podiatric Medical Association}, number = {5}, publisher = {Amer podiatric med assoc}, address = {Bethesda}, issn = {8750-7315}, doi = {10.7547/16-042}, pages = {375 -- 381}, year = {2017}, abstract = {Background: We sought to develop a standardized protocol for ultrasound (US) measurements of plantar fascia (PF) width and cross-sectional area (CSA), which may serve as additional outcome variables during US examinations of both healthy asymptomatic PF and in plantar fasciopathy and determine its interrater and intrarater reliability. Methods: Ten healthy individuals (20 feet) were enrolled. Participants were assessed twice by two raters each to determine intrarater and interrater reliability. For each foot, three transverse scans of the central bundle of the PF were taken at its insertion at the medial calcaneal tubercle, identified in real time on the plantar surface of the foot, using a fine wire technique. Reliability was determined using intraclass correlation coefficients (ICC), standard errors of measurement (SEM), and limits of agreement (LOA) expressed as percentages of the mean. Reliability of PF width and CSA measurements was determined using PF width and CSA measurements from one sonogram measured once and the mean of three measurements from three sonograms each measured once. Results: Ultrasound measurements of PF width and CSA showed a mean of 18.6 +/- 2.0 mm and 69.20 +/- 13.6 mm(2) respectively. Intra-reliability within both raters showed an ICC. 0.84 for width and ICC. 0.92 for CSA as well as a SEM\% and LOA\%, 10\% for both width and CSA. Inter-rater reliability showed an ICC of 0.82 for width and 0.87 for CSA as well as a SEM\% and LOA\%, 10\% for width and a SEM\%, 10\% and LOA\%, 20\% for CSA. Relative and absolute reliability within and between raters were higher when using the mean of three sonographs compared to one sonograph. Conclusions: Using this novel technique, PF CSA and width may be determined reliably using measurements from one sonogram or the mean of three sonograms. Measurement of PF CSA and width in addition to already established thickness and echogenicity measurements provides additional information on structural properties of the PF for clinicians and researchers in healthy and pathologic PF.}, language = {en} } @phdthesis{Rector2019, author = {Rector, Michael V.}, title = {The acute effect of exercise on flow-mediated dilation in young people with cystic fibrosis}, doi = {10.25932/publishup-43893}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-438938}, school = {Universit{\"a}t Potsdam}, pages = {121}, year = {2019}, abstract = {Introduction: Cystic fibrosis (CF) is a genetic disease which disrupts the function of an epithelial surface anion channel, CFTR (cystic fibrosis transmembrane conductance regulator). Impairment to this channel leads to inflammation and infection in the lung causing the majority of morbidity and mortality. However, CF is a multiorgan disease affecting many tissues, including vascular smooth muscle. Studies have revealed young people with cystic fibrosis lacking inflammation and infection still demonstrate vascular endothelial dysfunction, measured per flow-mediated dilation (FMD). In other disease cohorts, i.e. diabetic and obese, endurance exercise interventions have been shown improve or taper this impairment. However, long-term exercise interventions are risky, as well as costly in terms of time and resources. Nevertheless, emerging research has correlated the acute effects of exercise with its long-term benefits and advocates the study of acute exercise effects on FMD prior to longitudinal studies. The acute effects of exercise on FMD have previously not been examined in young people with CF, but could yield insights on the potential benefits of long-term exercise interventions. The aims of these studies were to 1) develop and test the reliability of the FMD method and its applicability to study acute exercise effects; 2) compare baseline FMD and the acute exercise effect on FMD between young people with and without CF; and 3) explore associations between the acute effects of exercise on FMD and demographic characteristics, physical activity levels, lung function, maximal exercise capacity or inflammatory hsCRP levels. Methods: Thirty young volunteers (10 people with CF, 10 non-CF and 10 non-CF active matched controls) between the ages of 10 and 30 years old completed blood draws, pulmonary function tests, maximal exercise capacity tests and baseline FMD measurements, before returning approximately 1 week later and performing a 30-min constant load training at 75\% HRmax. FMD measurements were taken prior, immediately after, 30 minutes after and 1 hour after constant load training. ANOVAs and repeated measures ANOVAs were employed to explore differences between groups and timepoints, respectively. Linear regression was implemented and evaluated to assess correlations between FMD and demographic characteristics, physical activity levels, lung function, maximal exercise capacity or inflammatory hsCRP levels. For all comparisons, statistical significance was set at a p-value of α < 0.05. Results: Young people with CF presented with decreased lung function and maximal exercise capacity compared to matched controls. Baseline FMD was also significantly decreased in the CF group (CF: 5.23\% v non-CF: 8.27\% v non-CF active: 9.12\%). Immediately post-training, FMD was significantly attenuated (approximately 40\%) in all groups with CF still demonstrating the most minimal FMD. Follow-up measurements of FMD revealed a slow recovery towards baseline values 30 min post-training and improvements in the CF and non-CF active groups 60 min post-training. Linear regression exposed significant correlations between maximal exercise capacity (VO2 peak), BMI and FMD immediately post-training. Conclusion: These new findings confirm that CF vascular endothelial dysfunction can be acutely modified by exercise and will aid in underlining the importance of exercise in CF populations. The potential benefits of long-term exercise interventions on vascular endothelial dysfunction in young people with CF warrants further investigation.}, language = {en} } @article{HadzicEichlerVoelleretal.2022, author = {Hadzic, Miralem and Eichler, Sarah and V{\"o}ller, Heinz and Salzwedel, Annett}, title = {Akzeptanz und Nutzung eines telemedizinischen Rehabilitationsprogramms f{\"u}r Patienten mit Knie- oder H{\"u}ft-Totalendoprothese}, series = {Bewegungstherapie und Gesundheitssport : B \& G ; offizielles Organ des Deutschen Verbandes f{\"u}r Gesundheitssport und Sporttherapie e.V. (DVGS)}, volume = {38}, journal = {Bewegungstherapie und Gesundheitssport : B \& G ; offizielles Organ des Deutschen Verbandes f{\"u}r Gesundheitssport und Sporttherapie e.V. (DVGS)}, number = {01}, publisher = {Thieme}, address = {Stuttgart}, organization = {Arbeitsgrp ReMove-It}, issn = {1613-0863}, doi = {10.1055/a-1714-3629}, pages = {20 -- 25}, year = {2022}, abstract = {Objective of the study: The long-term use of telemedical programs depends not only on their effectiveness, but also on patient acceptance and satisfaction. The effectiveness of telemedical exercise therapy for patients after implantation of a total knee or hip prosthesis and subsequent rehabilitation has already been examined in a randomized controlled study. This article focuses on the patient's acceptance and usage behaviour with regard to the tele-rehabilitation system. Methodology: 48 patients (53 +/- 7 years; 26 women; 35 hip/13 knee TEP) were questioned after a three-month telemedical movement therapy using the Telehealth Usability Questionnaire (TUQ) to determine the acceptance of the technology. The questionnaire consisted of 21 items (seven-point Likert scale) in six scales (e. g. usefulness, quality of interactions, reliability). System-specific questions were summarized on an additional scale. The results were presented as a percentage of the scale (100 estimates complete agreement). The usage behaviour was examined using system-generated process data for training and integrated voice/text messages. Results: The TUQ scales "Usefulness" (Mdn 95.2) and "Ease of use and learnability" (Mdn 92.9) were rated the highest, while "Reliability" (Mdn 57.1) and "Quality of interactions" ( Mdn 71.4) showed the lowest levels. The system-specific scale was placed in the upper quartile (Mdn 85.7). In the first week, 39 patients (81\%) and in the second 45 patients (94\%) performed at least one training exercise with the system. The proportion of active patients (>= 1 exercise/week) decreased in the further course to 75\% (n=36) in the 7th week and 48\% (n=23) in the 12th week. The system communication options were initially used frequently after the start of therapy: in the first week, 42 patients (88\%) sent messages, 47 patients (98\%) received messages from their therapist respectively. In week 7, 9 (19\%) and 13 (27\%) patients sent/received messages via the system respectively. Conclusion: Most of the patients perceived telemedical movement therapy as useful and user-friendly and seemed to be largely satisfied with the system. This proved to be well suited for short-term use of 6 to 8 weeks following subsequent rehabilitation.}, language = {de} } @article{HoermanndosSantosMorkischetal.2017, author = {H{\"o}rmann, Simon and dos Santos, Luara Ferreira and Morkisch, Nadine and Jettkowski, Katrin and Sillis, Moran and Devan, Hemakumar and Kanagasabai, Parimala S. and Schmidt, Henning and Kr{\"u}ger, J{\"o}rg and Dohle, Christian and Regenbrecht, Holger and Hale, Leigh and Cutfield, Nicholas J.}, title = {Computerised mirror therapy with Augmented Reflection Technology for early stroke rehabilitation}, series = {Disability and rehabilitation : an international, multidisciplinary journal}, volume = {39}, journal = {Disability and rehabilitation : an international, multidisciplinary journal}, publisher = {Routledge, Taylor \& Francis Group}, address = {Abingdon}, issn = {0963-8288}, doi = {10.1080/09638288.2017.1291765}, pages = {1503 -- 1514}, year = {2017}, abstract = {Purpose: New rehabilitation strategies for post-stroke upper limb rehabilitation employing visual stimulation show promising results, however, cost-efficient and clinically feasible ways to provide these interventions are still lacking. An integral step is to translate recent technological advances, such as in virtual and augmented reality, into therapeutic practice to improve outcomes for patients. This requires research on the adaptation of the technology for clinical use as well as on the appropriate guidelines and protocols for sustainable integration into therapeutic routines. Here, we present and evaluate a novel and affordable augmented reality system (Augmented Reflection Technology, ART) in combination with a validated mirror therapy protocol for upper limb rehabilitation after stroke. Results: The results showed that the combination and application of the Berlin Protocol for Mirror Therapy together with ART was feasible for clinical use. This combination was integrated into the therapeutic plan of subacute stroke patients at the two clinical locations where the second part of this research was conducted. Conclusions: Our findings pave the way for using technology to provide mirror therapy in clinical settings and show potential for the more effective use of inpatient time and enhanced recoveries for patients. IMPLICATIONS FOR REHABILITATION Computerised Mirror Therapy is feasible for clinical use Augmented Reflection Technology can be integrated as an adjunctive therapeutic intervention for subacute stroke patients in an inpatient setting Virtual Rehabilitation devices such as Augmented Reflection Technology have considerable potential to enhance stroke rehabilitation}, language = {en} } @article{UrbachAwiszusLeissetal.2020, author = {Urbach, Dietmar and Awiszus, Friedemann and Leiß, Sven and Venton, Tamsin and De Specht, Alexander Vincent and Apfelbacher, Christian}, title = {Associations of medications with lower odds of typical COVID-19 symptoms}, series = {JMIR public health and surveillance}, volume = {6}, journal = {JMIR public health and surveillance}, number = {4}, publisher = {JMIR Publications}, address = {Toronto}, issn = {2369-2960}, doi = {10.2196/22521}, pages = {10}, year = {2020}, abstract = {Background: As the COVID-19 pandemic continues to spread across the globe, the search for an effective medication to treat the symptoms of COVID-19 continues as well. It would be desirable to identify a medication that is already in use for another condition and whose side effect profile and safety data are already known and approved. Objective: The objective of this study was to evaluate the effect of different medications on typical COVID-19 symptoms by using data from an online surveillance survey. Methods: Between early April and late-July 2020, a total of 3654 individuals in Lower Saxony, Germany, participated in an online symptom-tracking survey conducted through the app covid-nein-danke.de. The questionnaire comprised items on typical COVID-19 symptoms, age range, gender, employment in patient-facing healthcare, housing status, postal code, previous illnesses, permanent medication, vaccination status, results of reverse transcription polymerase chain reaction (RT-PCR) and antibody tests for COVID-19 diagnosis, and consequent COVID-19 treatment if applicable. Odds ratio estimates with corresponding 95\% CIs were computed for each medication and symptom by using logistic regression models. Results: Data analysis suggested a statistically significant inverse relationship between typical COVID-19 symptoms self-reported by the participants and self-reported statin therapy and, to a lesser extent, antihypertensive therapy. When COVID-19 diagnosis was based on restrictive symptom criteria (ie, presence of 4 out of 7 symptoms) or a positive RT-PCR test, a statistically significant association was found solely for statins (odds ratio 0.28, 95\% CI 0.1-0.78). Conclusions: Individuals taking statin medication are more likely to have asymptomatic COVID-19, in which case they may be at an increased risk of transmitting the disease unknowingly. We suggest that the results of this study be incorporated into symptoms-based surveillance and decision-making protocols in regard to COVID-19 management. Whether statin therapy has a beneficial effect in combating COVID-19 cannot be deduced based on our findings and should be investigated by further study.}, language = {en} } @article{MehnertBrunettiSteinbrinketal.2013, author = {Mehnert, Jan and Brunetti, Maddalena and Steinbrink, Jens and Niedeggen, Michael and Dohle, Christian}, title = {Effect of a mirror-like illusion on activation in the precuneus assessed with functional near-infrared spectroscopy}, series = {Journal of biomedical optics}, volume = {18}, journal = {Journal of biomedical optics}, number = {6}, publisher = {SPIE}, address = {Bellingham}, issn = {1083-3668}, doi = {10.1117/1.JBO.18.6.066001}, pages = {9}, year = {2013}, abstract = {Mirror therapy is a therapy to treat patients with pain syndromes or hemiparesis after stroke. However, the underlying neurophysiologic mechanisms are not clearly understood. In order to determine the effect of a mirror-like illusion (MIR) on brain activity using functional near-infrared spectroscopy, 20 healthy right-handed subjects were examined. A MIR was induced by a digital horizontal inversion of the subjects' filmed hand. Optodes were placed on the primary motor cortex (M1) and the occipito-parietal cortex (precuneus, PC). Regions of interest (ROI) were defined a priori based on previous results of similar studies and confirmed by the analysis of effect sizes. Analysis of variance of the ROI signal revealed a dissociated pattern: at the PC, the MIR caused a significant inversion of a hemispheric lateralization opposite to the perceived hand, independent of the moving hand. In contrast, activity in M1 showed lateralization opposite to the moving hand, but revealed no mirror effect. These findings extend our understanding on interhemispheric rivalry and indicate that a MIR is integrated into visuomotor coordination similar to normal view, irrespective of the hand that is actually performing the task. (C) 2013 Society of Photo-Optical Instrumentation Engineers (SPIE)}, language = {en} } @article{WangFritzschBernardingetal.2013, author = {Wang, Jing and Fritzsch, Claire and Bernarding, Johannes and Holtze, Susanne and Mauritz, Karl-Heinz and Brunetti, Maddalena and Dohle, Christian}, title = {A comparison of neural mechanisms in mirror therapy and movement observation therapy}, series = {Journal of rehabilitation medicine : official journal of the UEMS European Board of Physical and Rehabilitation Medicine}, volume = {45}, journal = {Journal of rehabilitation medicine : official journal of the UEMS European Board of Physical and Rehabilitation Medicine}, number = {4}, publisher = {Foundation for Rehabilitation Information}, address = {Uppsala}, issn = {1650-1977}, doi = {10.2340/16501977-1127}, pages = {410 -- 413}, year = {2013}, abstract = {Objective: To compare lateralized cerebral activations elicited during self-initiated movement mirroring and observation of movements. Subjects: A total of 15 right-handed healthy subjects, age range 22-56 years. Methods: Functional imaging study comparing movement mirroring with movement observation, in both hands, in an otherwise identical setting. Imaging data were analysed using statistical parametric mapping software, with significance threshold set at p<0.01 (false discovery rate) and a minimum cluster size of 20 voxels. Results: Movement mirroring induced additional activation in primary and higher-order visual areas strictly contralateral to the limb seen by the subject. There was no significant difference of brain activity when comparing movement observation of somebody else's right hand with left hand. Conclusion: Lateralized cerebral activations are elicited by inversion of visual feedback (movement mirroring), but not by movement observation.}, language = {en} } @unpublished{ThiemeMehrholzPohletal.2013, author = {Thieme, Holm and Mehrholz, Jan and Pohl, Marcus and Behrens, Johann and Dohle, Christian}, title = {Mirror therapy for improving motor function after stroke}, series = {Stroke : a journal of cerebral circulation}, volume = {44}, journal = {Stroke : a journal of cerebral circulation}, number = {1}, publisher = {Lippincott Williams \& Wilkins}, address = {Philadelphia}, issn = {0039-2499}, doi = {10.1161/STROKEAHA.112.673087}, pages = {E1 -- E2}, year = {2013}, language = {en} } @article{HeidlerSalzwedelJoebgesetal.2018, author = {Heidler, Maria-Dorothea and Salzwedel, Annett and J{\"o}bges, Michael and L{\"u}ck, Olaf and Dohle, Christian and Seifert, Michael and von Helden, Andrea and Hollweg, Wibke and V{\"o}ller, Heinz}, title = {Decannulation of tracheotomized patients after long-term mechanical ventilation - results of a prospective multicentric study in German neurological early rehabilitation hospitals}, series = {BMC Anesthesiology}, volume = {18}, journal = {BMC Anesthesiology}, publisher = {BMC}, address = {London}, issn = {1471-2253}, doi = {10.1186/s12871-018-0527-3}, pages = {7}, year = {2018}, abstract = {Background: In the course of neurological early rehabilitation, decannulation is attempted in tracheotomized patients after weaning due to its considerable prognostic significance. We aimed to identify predictors of a successful tracheostomy decannulation. Methods: From 09/2014 to 03/2016, 831 tracheotomized and weaned patients (65.4 +/- 12.9 years, 68\% male) were included consecutively in a prospective multicentric observation study. At admission, sociodemographic and clinical data (e.g. relevant neurological and internistic diseases, duration of mechanical ventilation, tracheotomy technique, and nutrition) as well as functional assessments (Coma Recovery Scale-Revised (CRS-R), Early Rehabilitation Barthel Index, Bogenhausener Dysphagia Score) were collected. Complications and the success of the decannulation procedure were documented at discharge. Results: Four hundred seventy patients (57\%) were decannulated. The probability of decannulation was significantly negatively associated with increasing age (OR 0.68 per SD = 12.9 years, p < 0.001), prolonged duration of mechanical ventilation (OR 0.57 per 33.2 days, p < 0.001) and complications. An oral diet (OR 3.80; p < 0.001) and a higher alertness at admission (OR 3.07 per 7.18 CRS-R points; p < 0.001) were positively associated. Conclusions: This study identified practically measurable predictors of decannulation, which in the future can be used for a decannulation prognosis and supply optimization at admission in the neurological early rehabilitation clinic.}, language = {en} } @article{FritzschWangdosSantosetal.2014, author = {Fritzsch, Claire and Wang, Jing and dos Santos, Luara Ferreira and Mauritz, Karl-Heinz and Brunetti, Maddalena and Dohle, Christian}, title = {Different effects of the mirror illusion on motor and somatosensory processing}, series = {Restorative neurology and neuroscience}, volume = {32}, journal = {Restorative neurology and neuroscience}, number = {2}, publisher = {IOS Press}, address = {Amsterdam}, issn = {0922-6028}, doi = {10.3233/RNN-130343}, pages = {269 -- 280}, year = {2014}, abstract = {Purpose: Mirror therapy can improve motor and sensory functions, but effects of the mirror illusion on primary motor and somatosensory cortex could not be established consistently. Methods: Fifteen right handed healthy volunteers performed or observed a finger-thumb opposition task. Cerebral activations during normal movement (NOR), mirrored movement (MIR) and movement observation (OBS) by means of a video chain were recorded with functional magnetic resonance imaging (fMRI). Activation sizes in movement > static conditions were identified using SPM8 (p < 0.001, unc.) and attributed to predefined areas employing the Anatomy toolbox 1.8. Laterality indices for the responsive areas were calculated on the basis of the number of activated voxels. Results: Relevant bilateral BOLD responses were found in primary motor (M1) and somatosensory (S1 - BA 2, 3b and 3a) cortex, premotor and parietal areas and V5. When comparing MIR to NOR, no significant change of contralateral activation in M1 was found, but clearly at S1 with differences between hands. Conclusion: The mirror illusion does not elicit immediate changes in motor areas, yet there is a direct effect on somatosensory areas, especially for left hand movements. These results suggest different effects of mirror therapy on processing and rehabilitation of motor and sensory function.}, language = {en} } @book{OPUS4-24328, title = {K{\"o}rper, Kultur und Ideologie : Sport und Zeitgeist im 19. und 20. Jahrhundert ; [im Gedenken an Hajo Bernett (1921 - 1996), den Nestor der deutsch-j{\"u}dischen Sportgeschichte]}, series = {Studien zur Geistesgeschichte}, volume = {19}, journal = {Studien zur Geistesgeschichte}, editor = {Diekmann, Irene and Teichler, Hans Joachim}, publisher = {Philo}, address = {Bodenheim}, pages = {312 S.}, year = {1997}, language = {de} } @article{ThierHolmberg2020, author = {Thier, Anne and Holmberg, Christine}, title = {The patients' view}, series = {Disability and rehabilitation : an international, multidisciplinary journal}, volume = {44}, journal = {Disability and rehabilitation : an international, multidisciplinary journal}, number = {5}, publisher = {Taylor \& Francis Group}, address = {Abingdon}, issn = {0963-8288}, doi = {10.1080/09638288.2020.1775901}, pages = {661 -- 671}, year = {2020}, abstract = {Aim:The aim of this meta-synthesis is to find out what it means for patients with age-related macular degeneration to live with visual impairment, how they cope with the illness and how they experience their medical care, including vascular endothelial growth factor inhibitor therapy. Method:Inclusion criteria: qualitative studies exploring patients' experiences with age-related macular degeneration in their daily lives and with medical care, published in journals in English or German. The included studies were analysed following the rules and principles of grounded theory. Results:For the analysis, twenty-four articles matching the inclusion criteria were identified. Three main analytic themes emerged from the included studies: (i) a life shaped by losses; (ii) the burden of medical treatment; and (iii) coping with vision loss. For patients, visual impairment/vision loss means living with multiple losses in various domains of life. With the introduction of vascular endothelial growth factor inhibitor therapy, patients with neovascular age-related macular degeneration have a good chance of slowing down the disease progression; therapy does, however, also represent a major burden. Conclusion:New strategies need to be conceived to reduce the burden of medical treatment and to improve the dissemination of information about age-related macular degeneration.}, language = {en} } @phdthesis{Gutschow2009, author = {Gutschow, Ivonne}, title = {Auswirkungen des Cellvas-Mikrostromverfahrens auf die Leistungsf{\"a}higkeit bei Sportlern : Analyse m{\"o}glicher Effekte auf ausgew{\"a}hlte psycho-physische Belastungsparameter im Leistungssport}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-40224}, school = {Universit{\"a}t Potsdam}, year = {2009}, abstract = {Hohe Leistungsanspr{\"u}che im Wettkampfsport erfordern von den Athleten eine hohe sportliche Belastbarkeit. M{\"o}glichkeiten die Trainingsumf{\"a}nge und -intensit{\"a}ten zu erh{\"o}hen, sind z.T. ausgesch{\"o}pft. So bestehen nach wie vor Bestrebungen neue Wege zu finden, um m{\"o}gliche Leistungsreserven zu erschließen. Elektrotherapieverfahren haben sich im klinischen Alltag, u.a. zur Behandlung von Traumata, bew{\"a}hrt und werden h{\"a}ufig zum Zweck der Analgesierung, Verbesserung der Gewebedurchblutung und zur Muskelstimulation angewandt. Deren Einsatz im adjuvanten Bereich der Trainingsbegleitung wurde bislang nur vereinzelt beschrieben. In der vorliegenden Studie wurden die Auswirkungen einer elektromagnetischen Anwendungsform auf ausgew{\"a}hlte psycho-physische Parameter untersucht (Kontrollgruppenvergleich mit placebokontrolliertem Design), um Aussagen {\"u}ber praxisrelevante Ans{\"a}tze zur trainingsunterst{\"u}tzenden Betreuung abzuleiten. Es stellte sich die Frage, ob eine Intervention (15 x / 4 Wo.) mit frequenzmodulierten Wechselstr{\"o}men im vorwiegend niederfrequenten Wirkungsspektrum (0-10000Hz, 5 μA / cm², CellVAS®) zu einer Beeinflussung der untersuchten Parameter f{\"u}hren und dahingehend nachhaltige leistungsf{\"o}rdernde oder -reduzierende Effekte erzielt werden k{\"o}nnten. Des Weiteren sollte gepr{\"u}ft werden, inwiefen die erhobenen Parameter (PWC170, Squat-Jump, Lateralflexion der Wirbels{\"a}ule und SF36®) aussagekr{\"a}ftig genug sind. Die Wirksamkeit des Applikationsform wurde im Pr{\"a}-Post-Vergleich vor (T1), nach (T2) und 4 Wo. nach Abschluss (T3, Nachhaltigkeit) der Intervention analysiert. Die Teilnehmer der Kontrollgruppe erhielten vergleichbare Applikationen im Placebomodus. Das Probandenkollektiv bestand aus gesunden Leistungssportlern, deren Sportarten einen hohen Kraftausdaueranteil enthielten (n=127). Die Gruppenzuteilung erfolgte teilrandomisiert in Haupt- (HG) und Kontrollgruppe (KG). Zudem wurden die Gruppen zus{\"a}tzlich geschlechtsspezifisch getrennt. Im Untersuchungsverlauf ließen sich Ver{\"a}nderungen f{\"u}r die Leistungsparameter PWC170 und Squat Jump erkennen. Inwiefern diese Abweichungen auf den Einfluss der Intervention mit frequenzmodulierten Wechselstr{\"o}men im niederfrequenten Wirkungsspektrum zur{\"u}ckzuf{\"u}hren sind, konnte in dieser Untersuchung nicht eindeutig gekl{\"a}rt werden. Die nachgewiesenen Effekte ließen sich nach den zu Grunde liegenden wissenschaftlichen Standards nicht statistisch valide belegen. Der wissenschaftliche Nachweis einer m{\"o}gliche Leistungsver{\"a}nderung konnte nicht abschließend erbracht werden. Im therapeutischen Bereich hat die untersuchte Applikationsform, auf Basis der bestehen Studienlage, ihre Anwendung gefunden und kann bedenkenlos verwendet werden. F{\"u}r den Einsatz als unterst{\"u}tzendes Verfahren in der sportlichen Praxis besteht nach wie vor Bedarf an validen, randomisierten Studien, die die Wirksamkeit der Applikationsform auf psycho-physische Parameter von Athleten nachhaltig belegen, bevor sie in der sportlichen Praxis Anwendung finden sollten.}, language = {de} } @phdthesis{Barsuhn2016, author = {Barsuhn, Michael}, title = {Sportentwicklungsplanung als ein strategisches Steuerungsinstrument f{\"u}r kommunale Sportveranstaltungen}, series = {Schriften zur K{\"o}rperkultur ; 79}, journal = {Schriften zur K{\"o}rperkultur ; 79}, publisher = {Lit}, address = {Berlin}, isbn = {978-3-643-13525-4}, pages = {264}, year = {2016}, language = {de} } @article{AntoniewiczBrand2016, author = {Antoniewicz, Franziska and Brand, Ralf}, title = {Dropping Out or Keeping Up?}, series = {Frontiers in psychology}, volume = {7}, journal = {Frontiers in psychology}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1664-1078}, doi = {10.3389/fpsyg.2016.00838}, pages = {8}, year = {2016}, abstract = {The aim of this study was to examine how automatic evaluations of exercising (AEE) varied according to adherence to an exercise program. Eighty-eight participants (24.98 years ± 6.88; 51.1\% female) completed a Brief-Implicit Association Task assessing their AEE, positive and negative associations to exercising at the beginning of a 3-month exercise program. Attendance data were collected for all participants and used in a cluster analysis of adherence patterns. Three different adherence patterns (52 maintainers, 16 early dropouts, 20 late dropouts; 40.91\% overall dropouts) were detected using cluster analyses. Participants from these three clusters differed significantly with regard to their positive and negative associations to exercising before the first course meeting (η2p = 0.07). Discriminant function analyses revealed that positive associations to exercising was a particularly good discriminating factor. This is the first study to provide evidence of the differential impact of positive and negative associations on exercise behavior over the medium term. The findings contribute to theoretical understanding of evaluative processes from a dual-process perspective and may provide a basis for targeted interventions.}, language = {en} } @misc{AntoniewiczBrand2016, author = {Antoniewicz, Franziska and Brand, Ralf}, title = {Dropping Out or Keeping Up?}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-97060}, pages = {8}, year = {2016}, abstract = {The aim of this study was to examine how automatic evaluations of exercising (AEE) varied according to adherence to an exercise program. Eighty-eight participants (24.98 years ± 6.88; 51.1\% female) completed a Brief-Implicit Association Task assessing their AEE, positive and negative associations to exercising at the beginning of a 3-month exercise program. Attendance data were collected for all participants and used in a cluster analysis of adherence patterns. Three different adherence patterns (52 maintainers, 16 early dropouts, 20 late dropouts; 40.91\% overall dropouts) were detected using cluster analyses. Participants from these three clusters differed significantly with regard to their positive and negative associations to exercising before the first course meeting (η2p = 0.07). Discriminant function analyses revealed that positive associations to exercising was a particularly good discriminating factor. This is the first study to provide evidence of the differential impact of positive and negative associations on exercise behavior over the medium term. The findings contribute to theoretical understanding of evaluative processes from a dual-process perspective and may provide a basis for targeted interventions.}, language = {en} } @misc{SalzwedelHeidlerHauboldetal.2016, author = {Salzwedel, Annett and Heidler, Maria-Dorothea and Haubold, Kathrin and Schikora, Martin and Reibis, Rona Katharina and Wegscheider, Karl and J{\"o}bgens, Michael and V{\"o}ller, Heinz}, title = {Prevalence of mild cognitive impairment in employable patients after acute coronary event in cardiac rehabilitation}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-104113}, pages = {55 -- 60}, year = {2016}, abstract = {Introduction: Adequate cognitive function in patients is a prerequisite for successful implementation of patient education and lifestyle coping in comprehensive cardiac rehabilitation (CR) programs. Although the association between cardiovascular diseases and cognitive impairments (CIs) is well known, the prevalence particularly of mild CI in CR and the characteristics of affected patients have been insufficiently investigated so far. Methods: In this prospective observational study, 496 patients (54.5 ± 6.2 years, 79.8\% men) with coronary artery disease following an acute coronary event (ACE) were analyzed. Patients were enrolled within 14 days of discharge from the hospital in a 3-week inpatient CR program. Patients were tested for CI using the Montreal Cognitive Assessment (MoCA) upon admission to and discharge from CR. Additionally, sociodemographic, clinical, and physiological variables were documented. The data were analyzed descriptively and in a multivariate stepwise backward elimination regression model with respect to CI. Results: At admission to CR, the CI (MoCA score < 26) was determined in 182 patients (36.7\%). Significant differences between CI and no CI groups were identified, and CI group was associated with high prevalence of smoking (65.9 vs 56.7\%, P = 0.046), heavy (physically demanding) workloads (26.4 vs 17.8\%, P < 0.001), sick leave longer than 1 month prior to CR (28.6 vs 18.5\%, P = 0.026), reduced exercise capacity (102.5 vs 118.8 W, P = 0.006), and a shorter 6-min walking distance (401.7 vs 421.3 m, P = 0.021) compared to no CI group. The age- and education-adjusted model showed positive associations with CI only for sick leave more than 1 month prior to ACE (odds ratio [OR] 1.673, 95\% confidence interval 1.07-2.79; P = 0.03) and heavy workloads (OR 2.18, 95\% confidence interval 1.42-3.36; P < 0.01). Conclusion: The prevalence of CI in CR was considerably high, affecting more than one-third of cardiac patients. Besides age and education level, CI was associated with heavy workloads and a longer sick leave before ACE.}, language = {en} } @article{BrandSchlicht2008, author = {Brand, Ralf and Schlicht, Wolfgang}, title = {Sportpsychologische Interventionen in der Therapie und Rehabilitation}, isbn = {978-3-8017-0597-8}, year = {2008}, language = {de} } @article{GiannitsisRothLeithaeuseretal.2009, author = {Giannitsis, Evangelos and Roth, Heinz J{\"u}rgen and Leithaeuser, Renate M. and Scherhag, J{\"u}rgen and Beneke, Ralt and Katus, Hugo A.}, title = {New highly sensitivity assay used to measure cardiac troponin T concentration changes during a continuous 216- km marathon}, issn = {0009-9147}, doi = {10.1373/clinchem.2008.116566}, year = {2009}, language = {en} } @article{WickMoellerKruegeretal.2010, author = {Wick, Ditmar and M{\"o}ller, Sebastian and Kr{\"u}ger, Tom and Kittel, Ren{\´e}}, title = {Analyse und Optimierung angriffsspezifischer Technikelemente : individuelle Bewegungsprofile von Spitzenjudoka}, year = {2010}, language = {de} } @phdthesis{Bohlken2016, author = {Bohlken, Jens}, title = {Ambulante medikament{\"o}se Behandlung von Patienten mit Demenz}, school = {Universit{\"a}t Potsdam}, year = {2016}, language = {de} } @phdthesis{Klaedtke2008, author = {Klaedtke, Uta}, title = {Betriebssport in der DDR : Ph{\"a}nomene des Alltagssports zwischen physischer Reproduktion und politischer Anpassung am Beispiel des Stahl- und Walzwerkes Brandenburg}, publisher = {Sport \& Co Fachliteratur Verl.}, address = {Hamburg}, isbn = {978-3-9811094-1-2}, pages = {199 S. : graph. Darst.}, year = {2008}, language = {de} } @article{Baur2008, author = {Baur, J{\"u}rgen}, title = {Das Programm "Integration durch Sport" in Deutschland : Handlungsfeld alltagspolitischer Partizipation}, year = {2008}, language = {de} } @book{BaurMutzNobisetal.2008, author = {Baur, J{\"u}rgen and Mutz, Michael and Nobis, Tina and R{\"u}bner, Anne and Strahle, Yvonne}, title = {Basisdaten zum Programm "Integration durch Sport"}, series = {Ass-Materialien}, volume = {28}, journal = {Ass-Materialien}, address = {Potsdam}, issn = {1615-6129}, pages = {38 S.}, year = {2008}, language = {de} } @article{BaurRosenkranz2007, author = {Baur, J{\"u}rgen and Rosenkranz, Sebastian}, title = {Die Argumentationsfigur "Gesundheit - Sport - Fitness" im Sportverst{\"a}ndnis Jugendlicher}, isbn = {978-3-939390-97-8}, year = {2007}, language = {de} } @article{Wick2010, author = {Wick, Ditmar}, title = {Multidimensionale und komplexe Analyse kinematischer, dynamischer und elektromyographischer Daten im Jahresverlauf im Leistungsrudern (Skull, m{\"a}nnlich)}, year = {2010}, language = {de} } @article{Fussan2007, author = {Fussan, Nancy}, title = {Soziale Integration von jugendlichen Sportvereinsmitgliedern in die Kultur Gleichaltriger : Wettkampfsportler und Nicht-Wettkampfsportler im Vergleich}, isbn = {978-3-939390-66-4}, year = {2007}, language = {de} } @article{Stahl2007, author = {Stahl, Silvester}, title = {Der Sportbegriff im individuellen Gebrauch von Jugendlichen : ein Typenmodell}, isbn = {978-3-939390-97-8}, year = {2007}, language = {de} } @article{StrahleBurrmann2007, author = {Strahle, Yvonne and Burrmann, Ulrike}, title = {Das Selbst- und Fremdbild als Sportler}, isbn = {978-3-939390-97-8}, year = {2007}, language = {de} } @article{OPUS4-11054, title = {Sportmedizin f{\"u}r {\"A}rzte : Lehrbuch auf der Grundlage des Weiterbildungssystems der Deutschen Gesellschaft f{\"u}r Sportmedizin und Pr{\"a}vention (DGSP)}, editor = {Dickhuth, Hans-Hermann and Meyer, Frank and R{\"o}cker, Kai and Berg, Alois}, publisher = {Dt. {\"A}rzte-Verl.}, address = {K{\"o}ln}, isbn = {978-3-7691-0472-1}, pages = {636 S.}, year = {2007}, language = {de} } @book{OPUS4-11058, title = {Zum Sportverst{\"a}ndnis von Jugendlichen : was erfassen schriftliche Jugendsporterhebungen?}, series = {Wissenschaftliche Berichte und Materialien / Bundesinstitut f{\"u}r Sportwissenschaft, Bonn}, volume = {05}, journal = {Wissenschaftliche Berichte und Materialien / Bundesinstitut f{\"u}r Sportwissenschaft, Bonn}, editor = {Burrmann, Ulrike}, publisher = {Sport und Buch Strau\ß}, address = {K{\"o}ln}, isbn = {3-939390-97-8}, pages = {426 S.}, year = {2007}, language = {de} } @article{Burrmann2007, author = {Burrmann, Ulrike}, title = {Zur Einf{\"u}hrung}, isbn = {978-3-939390-97-8}, year = {2007}, language = {de} } @article{Baur2007, author = {Baur, J{\"u}rgen}, title = {Einleitung zu einem Forschungsbericht}, isbn = {978-3-939390-66-4}, year = {2007}, language = {de} } @article{BurrmannBaur2007, author = {Burrmann, Ulrike and Baur, J{\"u}rgen}, title = {Die Sicht der Jugend auf den Wettkampfsport}, isbn = {978-3-939390-97-8}, year = {2007}, language = {de} } @article{MerzigerBaur2007, author = {Merziger, Anke and Baur, J{\"u}rgen}, title = {Die Sicht der Jugendlichen auf kommerzielle Sportangebote}, isbn = {978-3-939390-97-8}, year = {2007}, language = {de} } @article{Stahl2007, author = {Stahl, Silvester}, title = {Methoden der Datenerhebung und -aufbereitung}, isbn = {978-3-939390-97-8}, year = {2007}, language = {de} } @article{PolchowRuebner2007, author = {Polchow, Sandra and R{\"u}bner, Anne}, title = {Kurzportraits}, isbn = {978-3-939390-97-8}, year = {2007}, language = {de} } @article{Burrmann2007, author = {Burrmann, Ulrike}, title = {Die Sicht der Jugendlichen auf den vereinsorganisierten Sport}, isbn = {978-3-939390-97-8}, year = {2007}, language = {de} } @article{Stahl2007, author = {Stahl, Silvester}, title = {Fecetten des Sportbegriffs im Verst{\"a}ndnis von Jugendlichen}, isbn = {978-3-939390-97-8}, year = {2007}, language = {de} } @article{Baur2007, author = {Baur, J{\"u}rgen}, title = {Alterstypisierungen im Sport}, isbn = {978-3-939390-97-8}, year = {2007}, language = {de} } @article{StrahleBurrmann2007, author = {Strahle, Yvonne and Burrmann, Ulrike}, title = {Methodische Triangulation im Rahmen der Validit{\"a}tsstudie}, isbn = {978-3-939390-97-8}, year = {2007}, language = {de} } @article{Baur2007, author = {Baur, J{\"u}rgen}, title = {Sport f{\"u}r "harte Jungs" und "softe M{\"a}dchen": Geschlechtertypisierungen im Sport?}, isbn = {978-3-939390-97-8}, year = {2007}, language = {de} } @article{Stahl2007, author = {Stahl, Silvester}, title = {"So richtig Sport" - Differenzierungsmuster im Sportverst{\"a}ndnis von Jugendlichen}, isbn = {978-3-939390-97-8}, year = {2007}, language = {de} } @book{OPUS4-11155, title = {Integration von Jugendlichen mit Migrationshintergrund}, series = {ASS-Materialien}, volume = {23}, journal = {ASS-Materialien}, editor = {Nobis, Tina and Baur, J{\"u}rgen}, publisher = {Univ.}, address = {Potsdam}, issn = {1615-6129}, pages = {104 S.}, year = {2007}, language = {de} } @article{NobisFussan2007, author = {Nobis, Tina and Fussan, Nancy}, title = {Soziale Integration von Jugendlichen mit Migrationshintergrund}, isbn = {978-3-939390-66-4}, year = {2007}, language = {de} } @article{FussanNobis2007, author = {Fussan, Nancy and Nobis, Tina}, title = {Zur Partizipation von Jugendlichen mit Migrationshintergrund in Sportvereinen}, isbn = {978-3-939390-66-4}, year = {2007}, language = {de} } @article{Fussan2007, author = {Fussan, Nancy}, title = {Integration von Jugendlichen mit Migrationshintergrund in Peer-Netzwerke: Sozialisationsvorteile sportvereinsgebundener Jugendlicher?}, isbn = {978-3-939390-66-4}, year = {2007}, language = {de} } @article{Nobis2007, author = {Nobis, Tina}, title = {Politische Orientierungen von Jugendlichen mit Migrationshintergrund: Sportvereinsmitglieder und Nicht- Mitglieder im Vergleich}, isbn = {978-3-939390-66-4}, year = {2007}, language = {de} } @article{Nobis2007, author = {Nobis, Tina}, title = {Einstellungen Jugendlicher Sportvereinsmitglieder zur ausl{\"a}ndischen Bev{\"o}lkerung}, isbn = {978-3-939390-66-4}, year = {2007}, language = {de} } @article{BaurFussan2007, author = {Baur, J{\"u}rgen and Fussan, Nancy}, title = {Sekund{\"a}ranalysen zur sozialen Integration von jugendlichen Sportvereinsmitgliedern und Nicht-Mitgliedern}, isbn = {978-3-939390-66-4}, year = {2007}, language = {de} } @book{OPUS4-11183, title = {Soziale Integration vereinsorganisierter Jugendlicher}, series = {Wissenschaftliche Berichte und Materialien / Bundesinstitut f{\"u}r Sportwissenschaft, Bonn}, volume = {2007,9}, journal = {Wissenschaftliche Berichte und Materialien / Bundesinstitut f{\"u}r Sportwissenschaft, Bonn}, editor = {Nobis, Tina and Baur, J{\"u}rgen}, publisher = {Sport und Buch Strau\ß}, address = {K{\"o}ln}, isbn = {3-939390-66-4}, pages = {352 S.}, year = {2007}, language = {de} } @article{Fussan2007, author = {Fussan, Nancy}, title = {Einbindung von Jugendlichen in Peer-Netzwerke : Sportvereinsmitglieder und Nicht-Mitglieder im Vergleich}, isbn = {978-3-939390-66-4}, year = {2007}, language = {de} } @article{Fussan2007, author = {Fussan, Nancy}, title = {Qualit{\"a}t der Peerbeziehungen von Jugendlichen: Sportvereinsmitglier und Nicht- Mitglieder im Vergleich}, isbn = {978-3-939390-66-4}, year = {2007}, language = {de} } @article{Nobis2007, author = {Nobis, Tina}, title = {Vorbemerkungen zum freiwilligen Engagement Jugendlicher}, isbn = {978-3-939390-66-4}, year = {2007}, language = {de} } @article{Nobis2007, author = {Nobis, Tina}, title = {Freiwilliges Engagement jugendlicher Sportvereinsmitglieder}, isbn = {978-3-939390-66-4}, year = {2007}, language = {de} } @article{Nobis2007, author = {Nobis, Tina}, title = {Sozialstrukturelle Variationen im freiwilligen Engagement jugendlicher Sportvereinsmitglieder}, isbn = {978-3-939390-66-4}, year = {2007}, language = {de} } @article{Nobis2007, author = {Nobis, Tina}, title = {Freiwilliges Engagement Jugendlicher in verschiedenen Freiwilligenvereinigungen}, isbn = {978-3-939390-66-4}, year = {2007}, language = {de} } @article{Nobis2007, author = {Nobis, Tina}, title = {Vorbemerkungen zur politischen Sozialisation in Freiwilligenvereinigungen}, isbn = {978-3-939390-66-4}, year = {2007}, language = {de} } @article{MutzNobis2007, author = {Mutz, Michael and Nobis, Tina}, title = {Zur Mitgliederstruktur von Freiwilligenvereinigungen}, isbn = {978-3-939390-66-4}, year = {2007}, language = {de} } @article{Nobis2007, author = {Nobis, Tina}, title = {Politisches Interesse jugendlicher Sportvereinsmitglieder}, isbn = {978-3-939390-66-4}, year = {2007}, language = {de} } @article{MutzNobis2007, author = {Mutz, Michael and Nobis, Tina}, title = {Politische Sozialisationsleistungen von Freiwilligenvereinigungen: Sportvereine und andere Freiwilligenvereinigungen im Vergleich}, isbn = {978-3-939390-66-4}, year = {2007}, language = {de} } @article{Krueger2009, author = {Kr{\"u}ger, Tom}, title = {Biomechanische Aspekte in leichtathletischen Disziplinen}, isbn = {3-938509-59-7}, year = {2009}, language = {de} } @article{Teichler2007, author = {Teichler, Hans Joachim}, title = {Die faschistische Epoche des IOC}, year = {2007}, language = {de} } @article{Teichler2007, author = {Teichler, Hans Joachim}, title = {Zur Erinnerungskultur im deutschen Sport nach 1945}, year = {2007}, language = {de} } @article{Teichler2007, author = {Teichler, Hans Joachim}, title = {Der Weltkongress f{\"u}r Freizeit und Erholung 1936 in Hamburg : ein vergessener Teil der Geschichte des IOC und der Olympischen Spiele von Berlin 1936}, year = {2007}, language = {de} } @article{BergmannMayWick2009, author = {Bergmann, Julian and May, Lars and Wick, Ditmar}, title = {Stabilit{\"a}t sportlicher Begabung}, isbn = {978-3-88020-533-8}, year = {2009}, language = {de} } @article{Strahle2007, author = {Strahle, Yvonne}, title = {Zum wettkampfsportlichen Engagement von Jugendlichen}, isbn = {978-3-939390-97-8}, year = {2007}, language = {de} } @article{Teichler2006, author = {Teichler, Hans Joachim}, title = {Fußball in der DDR}, year = {2006}, language = {de} } @article{Burrmann2006, author = {Burrmann, Ulrike}, title = {Entwicklung des Selbstkonzepts}, isbn = {3-939390-83-6}, year = {2006}, language = {de} } @article{Burrmann2006, author = {Burrmann, Ulrike}, title = {Sport im Kontext von Freizeitengagements Jugendlicher : aus dem Brandenburgischen L{\"a}ngsschnitt}, year = {2006}, language = {de} } @article{Nobis2006, author = {Nobis, Tina}, title = {Vom Verr{\"a}ter zum M{\"a}rthyrer : ein R{\"u}ckblick auf Muhammad Ali}, year = {2006}, language = {de} } @book{Schroeder2006, author = {Schr{\"o}der, Manfred}, title = {Burnout unvermeidlich?}, series = {Potsdamer Studien zur Geschichte von Sport und Gesundheit}, volume = {2}, journal = {Potsdamer Studien zur Geschichte von Sport und Gesundheit}, publisher = {Univ.-Verl.}, address = {Potsdam}, isbn = {978-3-937786-96-4}, issn = {1611-4922}, pages = {385 S.}, year = {2006}, language = {de} } @phdthesis{Wagner2006, author = {Wagner, Ringo}, title = {Der vergessene Sportverband der DDR : die Gesellschaft f{\"u}r Sport und Technik in sporthistorischer Perspektive}, series = {Sportforum. Dissertations- und Habilitationsschriftenreihe}, volume = {16}, journal = {Sportforum. Dissertations- und Habilitationsschriftenreihe}, publisher = {Meyer \& Meyer}, address = {Aachen}, isbn = {978-3-89899-283-1}, pages = {301 S.}, year = {2006}, language = {de} } @phdthesis{Reschke2016, author = {Reschke, Antje}, title = {Effectiveness of a foot orthosis on muscular activity in functional ankle instability}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-104366}, school = {Universit{\"a}t Potsdam}, pages = {XII, 155, XXXVIII}, year = {2016}, abstract = {A majority of studies documented a reduced ankle muscle activity, particularly of the peroneus longus muscle (PL), in patients with functional ankle instability (FI). It is considered valid that foot orthoses as well as sensorimotor training have a positive effect on ankle muscle activity in healthy individuals and those with lower limb overuse injuries or flat arched feet (reduced reaction time by sensorimotor exercises; increased ankle muscle amplitude by orthoses use). However, the acute- and long-term influence of foot orthoses on ankle muscle activity in individuals with FI is unknown. AIMS: The present thesis addressed (1a) acute- and (1b) long-term effects of foot orthoses compared to sensorimotor training on ankle muscle activity in patients with FI. (2) Further, it was investigated if the orthosis intervention group demonstrate higher ankle muscle activity by additional short-term use of a measurement in-shoe orthosis (compared to short-term use of "shoe only") after intervention. (3) As prerequisite, it was evaluated if ankle muscle activity can be tested reliably and (4) if this differs between healthy individuals and those with FI. METHODS: Three intervention groups (orthosis group [OG], sensorimotor training group [SMTG], control group [CG]), consisting of both, healthy individuals and those with FI, underwent one longitudinal investigation (randomised controlled trial). Throughout 6 weeks of intervention, OG wore an in-shoe orthosis with a specific "PL stimulation module", whereas SMTG conducted home-based exercises. CG served to measure test-retest reliability of ankle muscle activity (PL, M. tibialis anterior [TA] and M. gastrocnemius medialis [GM]). Pre- and post-intervention, ankle muscle activity (EMG amplitude) was recorded during "normal" unperturbed (NW) and perturbed walking (PW) on a split-belt treadmill (stimulus 200 ms post initial heel contact [IC]) as well as during side cutting (SC), each while wearing "shoes only" and additional measurement in-shoe orthoses (randomized order). Normalized RMS values (100\% MVC, mean±SD) were calculated pre- (100-50 ms) and post (200-400 ms) - IC. RESULTS: (3) Test-retest reliability showed a high range of values in healthy individuals and those with FI. (4) Compared to healthy individuals, patients with FI demonstrated lower PL pre-activity during SC, however higher PL pre-activity for NW and PW. (1a) Acute orthoses use did not influence ankle muscle activity. (1b) For most conditions, sensorimotor training was more effective in individuals with FI than long-term orthotic intervention (increased: PL and GM pre-activity and TA reflex-activity for NW, PL pre-activity and TA, PL and GM reflex-activity for SC, PL reflex-activity for PW). However, prolonged orthoses use was more beneficial in terms of an increase in GM pre-activity during SC. For some conditions, long-term orthoses intervention was as effective as sensorimotor training for individuals with FI (increased: PL pre-activity for PW, TA pre-activity for SC, PL and GM reflex-activity for NW). Prolonged orthoses use was also advantageous in healthy individuals (increased: PL and GM pre-activity for NW and PW, PL pre-activity for SC, TA and PL reflex-activity for NW, PL and GM reflex-activity for PW). (2) The orthosis intervention group did not present higher ankle muscle activity by the additional short-term use of a measurement in-shoe orthosis at re-test after intervention. CONCLUSION: High variations of reproducibility reflect physiological variability in muscle activity during gait and therefore deemed acceptable. The main findings confirm the presence of sensorimotor long-term effects of specific foot orthoses in healthy individuals (primary preventive effect) and those with FI (therapeutic effect). Neuromuscular compensatory feedback- as well as anticipatory feedforward adaptation mechanism to prolonged orthoses use, specifically of the PL muscle, underpins the key role of PL in providing essential dynamic ankle joint stability. Due to its advantages over sensorimotor training (positive subjective feedback in terms of comfort, time-and-cost-effectiveness), long-term foot orthoses use can be recommended as an applicable therapy alternative in the treatment of FI. Long-term effect of foot orthoses in a population with FI must be validated in a larger sample size with longer follow-up periods to substantiate the generalizability of the existing outcomes.}, language = {en} }