@article{AdamHahnHoelscheretal.2021, author = {Adam, Jan P. and Hahn, Michelle and H{\"o}lscher, Ines and H{\"o}schel, Heike and Janzen, Stella and K{\"o}gel, Lukas}, title = {Automatisierung von Routinet{\"a}tigkeiten im {\"o}ffentlichen Dienst}, series = {Verwaltung \& Management}, volume = {27}, journal = {Verwaltung \& Management}, number = {1}, publisher = {Nomos}, address = {Baden-Baden}, issn = {0947-9856}, doi = {10.5771/0947-9856-2021-1-39}, pages = {39 -- 48}, year = {2021}, abstract = {Auf Basis einer Umfrage unter 300 Besch{\"a}ftigten im {\"o}ffentlichen Dienst untersucht dieser Beitrag, welche m{\"o}glichen Auswirkungen die Digitale Transformation auf das T{\"a}tigkeitsprofil von Mitarbeiterinnen und Mitarbeitern im {\"o}ffentlichen Sektor haben kann. Zum einen finden sich erste Hinweise auf signifikante Effizienzpotenziale durch Automatisierung im {\"o}ffentlichen Sektor. Zum anderen wird deutlich, dass die Mitarbeiterinnen und Mitarbeiter dieser Entwicklung mehrheitlich positiv gegen{\"u}berstehen und sie aktiv an der Verbesserung von Dienstleistungen mitwirken wollen. Aus diesen Erkenntnissen k{\"o}nnen zahlreiche Handlungsimplikationen f{\"u}r Ver{\"a}nderungsprojekte in der Praxis abgeleitet werden. Gleichzeitig ruft dieser Beitrag dazu auf, die Folgen der Digitalen Transformation f{\"u}r Mitarbeiterinnen und Mitarbeiter noch besser zu erforschen.}, language = {de} } @inproceedings{InaebnitDennis2021, author = {In{\"a}bnit, Thomas and Dennis, Alice B.}, title = {The mitochondrial genome of Melampus bidentatus (Panpulmonata, Ellobioidea)}, series = {Integrative and comparative biology / Society of Integrative and Comparative Biology}, volume = {61}, booktitle = {Integrative and comparative biology / Society of Integrative and Comparative Biology}, number = {Supplement 1}, publisher = {Oxford University Press}, address = {Oxford}, issn = {1540-7063}, pages = {E405 -- E405}, year = {2021}, language = {en} } @article{BastianRobelSchmidtetal.2021, author = {Bastian, Philipp U. and Robel, Nathalie and Schmidt, Peter and Schrumpf, Tim and G{\"u}nter, Christina and Roddatis, Vladimir and Kumke, Michael Uwe}, title = {Resonance energy transfer to track the motion of lanthanide ions}, series = {Biosensors : open access journal}, volume = {11}, journal = {Biosensors : open access journal}, number = {12}, publisher = {MDPI}, address = {Basel}, issn = {2079-6374}, doi = {10.3390/bios11120515}, pages = {23}, year = {2021}, abstract = {The imagination of clearly separated core-shell structures is already outdated by the fact, that the nanoparticle core-shell structures remain in terms of efficiency behind their respective bulk material due to intermixing between core and shell dopant ions. In order to optimize the photoluminescence of core-shell UCNP the intermixing should be as small as possible and therefore, key parameters of this process need to be identified. In the present work the Ln(III) ion migration in the host lattices NaYF4 and NaGdF4 was monitored. These investigations have been performed by laser spectroscopy with help of lanthanide resonance energy transfer (LRET) between Eu(III) as donor and Pr(III) or Nd(III) as acceptor. The LRET is evaluated based on the Forster theory. The findings corroborate the literature and point out the migration of ions in the host lattices. Based on the introduced LRET model, the acceptor concentration in the surrounding of one donor depends clearly on the design of the applied core-shell-shell nanoparticles. In general, thinner intermediate insulating shells lead to higher acceptor concentration, stronger quenching of the Eu(III) donor and subsequently stronger sensitization of the Pr(III) or the Nd(III) acceptors. The choice of the host lattice as well as of the synthesis temperature are parameters to be considered for the intermixing process.}, language = {en} } @article{BanbaraInoueKaufmannetal.2018, author = {Banbara, Mutsunori and Inoue, Katsumi and Kaufmann, Benjamin and Okimoto, Tenda and Schaub, Torsten and Soh, Takehide and Tamura, Naoyuki and Wanko, Philipp}, title = {teaspoon}, series = {Annals of operation research}, volume = {275}, journal = {Annals of operation research}, number = {1}, publisher = {Springer}, address = {Dordrecht}, issn = {0254-5330}, doi = {10.1007/s10479-018-2757-7}, pages = {3 -- 37}, year = {2018}, abstract = {Answer Set Programming (ASP) is an approach to declarative problem solving, combining a rich yet simple modeling language with high performance solving capacities. We here develop an ASP-based approach to curriculum-based course timetabling (CB-CTT), one of the most widely studied course timetabling problems. The resulting teaspoon system reads a CB-CTT instance of a standard input format and converts it into a set of ASP facts. In turn, these facts are combined with a first-order encoding for CB-CTT solving, which can subsequently be solved by any off-the-shelf ASP systems. We establish the competitiveness of our approach by empirically contrasting it to the best known bounds obtained so far via dedicated implementations. Furthermore, we extend the teaspoon system to multi-objective course timetabling and consider minimal perturbation problems.}, language = {en} } @article{FriouxSchaubSchellhornetal.2019, author = {Frioux, Cl{\´e}mence and Schaub, Torsten and Schellhorn, Sebastian and Siegel, Anne and Wanko, Philipp}, title = {Hybrid metabolic network completion}, series = {Theory and practice of logic programming}, volume = {19}, journal = {Theory and practice of logic programming}, number = {1}, publisher = {Cambridge University Press}, address = {New York}, issn = {1471-0684}, doi = {10.1017/S1471068418000455}, pages = {83 -- 108}, year = {2019}, abstract = {Metabolic networks play a crucial role in biology since they capture all chemical reactions in an organism. While there are networks of high quality for many model organisms, networks for less studied organisms are often of poor quality and suffer from incompleteness. To this end, we introduced in previous work an answer set programming (ASP)-based approach to metabolic network completion. Although this qualitative approach allows for restoring moderately degraded networks, it fails to restore highly degraded ones. This is because it ignores quantitative constraints capturing reaction rates. To address this problem, we propose a hybrid approach to metabolic network completion that integrates our qualitative ASP approach with quantitative means for capturing reaction rates. We begin by formally reconciling existing stoichiometric and topological approaches to network completion in a unified formalism. With it, we develop a hybrid ASP encoding and rely upon the theory reasoning capacities of the ASP system dingo for solving the resulting logic program with linear constraints over reals. We empirically evaluate our approach by means of the metabolic network of Escherichia coli. Our analysis shows that our novel approach yields greatly superior results than obtainable from purely qualitative or quantitative approaches.}, language = {en} } @article{JanhunenKaminskiOstrowskietal.2017, author = {Janhunen, Tomi and Kaminski, Roland and Ostrowski, Max and Schellhorn, Sebastian and Wanko, Philipp and Schaub, Torsten}, title = {Clingo goes linear constraints over reals and integers}, series = {Theory and practice of logic programming}, volume = {17}, journal = {Theory and practice of logic programming}, publisher = {Cambridge Univ. Press}, address = {New York}, issn = {1471-0684}, doi = {10.1017/S1471068417000242}, pages = {872 -- 888}, year = {2017}, abstract = {The recent series 5 of the Answer Set Programming (ASP) system clingo provides generic means to enhance basic ASP with theory reasoning capabilities. We instantiate this framework with different forms of linear constraints and elaborate upon its formal properties. Given this, we discuss the respective implementations, and present techniques for using these constraints in a reactive context. More precisely, we introduce extensions to clingo with difference and linear constraints over integers and reals, respectively, and realize them in complementary ways. Finally, we empirically evaluate the resulting clingo derivatives clingo[dl] and clingo[lp] on common language fragments and contrast them to related ASP systems.}, language = {en} } @article{ContierWeymarWartenburgeretal.2022, author = {Contier, Friederike and Weymar, Mathias and Wartenburger, Isabell and Rabovsky, Milena}, title = {Sustained attention as measured by reaction time variability is a strong modulator for the P600, but not the N400}, series = {Journal of cognitive neuroscience}, volume = {34}, journal = {Journal of cognitive neuroscience}, number = {12}, publisher = {MIT Press}, address = {Cambridge}, issn = {0898-929X}, doi = {10.1162/jocn_a_01918}, pages = {2297 -- 2310}, year = {2022}, abstract = {The functional significance of the two prominent language-related ERP components N400 and P600 is still under debate. It has recently been suggested that one important dimension along which the two vary is in terms of automaticity versus attentional control, with N400 amplitudes reflecting more automatic and P600 amplitudes reflecting more controlled aspects of sentence comprehension. The availability of executive resources necessary for controlled processes depends on sustained attention, which fluctuates over time. Here, we thus tested whether P600 and N400 amplitudes depend on the level of sustained attention. We reanalyzed EEG and behavioral data from a sentence processing task by Sassenhagen and Bornkessel-Schlesewsky [The P600 as a correlate of ventral attention network reorientation. Cortex, 66, A3-A20, 2015], which included sentences with morphosyntactic and semantic violations. Participants read sentences phrase by phrase and indicated whether a sentence contained any type of anomaly as soon as they had the relevant information. To quantify the varying degrees of sustained attention, we extracted a moving reaction time coefficient of variation over the entire course of the task. We found that the P600 amplitude was significantly larger during periods of low reaction time variability (high sustained attention) than in periods of high reaction time variability (low sustained attention). In contrast, the amplitude of the N400 was not affected by reaction time variability. These results thus suggest that the P600 component is sensitive to sustained attention whereas the N400 component is not, which provides independent evidence for accounts suggesting that P600 amplitudes reflect more controlled and N400 amplitudes reflect more automatic aspects of sentence comprehension.}, language = {en} } @article{SmithDupontMcCarthyetal.2019, author = {Smith, Sarah R. and Dupont, Chris L. and McCarthy, James K. and Broddrick, Jared T. and Obornik, Miroslav and Horak, Ales and F{\"u}ssy, Zolt{\´a}n and Cihlar, Jaromir and Kleessen, Sabrina and Zheng, Hong and McCrow, John P. and Hixson, Kim K. and Araujo, Wagner L. and Nunes-Nesi, Adriano and Fernie, Alisdair and Nikoloski, Zoran and Palsson, Bernhard O. and Allen, Andrew E.}, title = {Evolution and regulation of nitrogen flux through compartmentalized metabolic networks in a marine diatom}, series = {Nature Communications}, volume = {10}, journal = {Nature Communications}, publisher = {Nature Publ. Group}, address = {London}, issn = {2041-1723}, doi = {10.1038/s41467-019-12407-y}, pages = {14}, year = {2019}, abstract = {Diatoms outcompete other phytoplankton for nitrate, yet little is known about the mechanisms underpinning this ability. Genomes and genome-enabled studies have shown that diatoms possess unique features of nitrogen metabolism however, the implications for nutrient utilization and growth are poorly understood. Using a combination of transcriptomics, proteomics, metabolomics, fluxomics, and flux balance analysis to examine short-term shifts in nitrogen utilization in the model pennate diatom in Phaeodactylum tricornutum, we obtained a systems-level understanding of assimilation and intracellular distribution of nitrogen. Chloroplasts and mitochondria are energetically integrated at the critical intersection of carbon and nitrogen metabolism in diatoms. Pathways involved in this integration are organelle-localized GS-GOGAT cycles, aspartate and alanine systems for amino moiety exchange, and a split-organelle arginine biosynthesis pathway that clarifies the role of the diatom urea cycle. This unique configuration allows diatoms to efficiently adjust to changing nitrogen status, conferring an ecological advantage over other phytoplankton taxa.}, language = {en} } @article{KamranfarXueTohgeetal.2018, author = {Kamranfar, Iman and Xue, Gang-Ping and Tohge, Takayuki and Sedaghatmehr, Mastoureh and Fernie, Alisdair and Balazadeh, Salma and Mueller-Roeber, Bernd}, title = {Transcription factor RD26 is a key regulator of metabolic reprogramming during dark-induced senescence}, series = {New phytologist : international journal of plant science}, volume = {218}, journal = {New phytologist : international journal of plant science}, number = {4}, publisher = {Wiley}, address = {Hoboken}, issn = {0028-646X}, doi = {10.1111/nph.15127}, pages = {1543 -- 1557}, year = {2018}, abstract = {Leaf senescence is a key process in plants that culminates in the degradation of cellular constituents and massive reprogramming of metabolism for the recovery of nutrients from aged leaves for their reuse in newly developing sinks. We used molecular-biological and metabolomics approaches to identify NAC transcription factor (TF) RD26 as an important regulator of metabolic reprogramming in Arabidopsis thaliana. RD26 directly activates CHLOROPLAST VESICULATION (CV), encoding a protein crucial for chloroplast protein degradation, concomitant with an enhanced protein loss in RD26 over-expressors during senescence, but a reduced decline of protein in rd26 knockout mutants. RD26 also directly activates LKR/SDH involved in lysine catabolism, and PES1 important for phytol degradation. Metabolic profiling revealed reduced c-aminobutyric acid (GABA) in RD26 overexpressors, accompanied by the induction of respective catabolic genes. Degradation of lysine, phytol and GABA is instrumental for maintaining mitochondrial respiration in carbon-limiting conditions during senescence. RD26 also supports the degradation of starch and the accumulation of mono-and disaccharides during senescence by directly enhancing the expression of AMY1, SFP1 and SWEET15 involved in carbohydrate metabolism and transport. Collectively, during senescence RD26 acts by controlling the expression of genes across the entire spectrum of the cellular degradation hierarchy.}, language = {en} } @article{FerrariProostJanowskietal.2019, author = {Ferrari, Camilla and Proost, Sebastian and Janowski, Marcin Andrzej and Becker, J{\"o}rg and Nikoloski, Zoran and Bhattacharya, Debashish and Price, Dana and Tohge, Takayuki and Bar-Even, Arren and Fernie, Alisdair and Stitt, Mark and Mutwil, Marek}, title = {Kingdom-wide comparison reveals the evolution of diurnal gene expression in Archaeplastida}, series = {Nature Communications}, volume = {10}, journal = {Nature Communications}, publisher = {Nature Publ. Group}, address = {London}, issn = {2041-1723}, doi = {10.1038/s41467-019-08703-2}, pages = {13}, year = {2019}, abstract = {Plants have adapted to the diurnal light-dark cycle by establishing elaborate transcriptional programs that coordinate many metabolic, physiological, and developmental responses to the external environment. These transcriptional programs have been studied in only a few species, and their function and conservation across algae and plants is currently unknown. We performed a comparative transcriptome analysis of the diurnal cycle of nine members of Archaeplastida, and we observed that, despite large phylogenetic distances and dramatic differences in morphology and lifestyle, diurnal transcriptional programs of these organisms are similar. Expression of genes related to cell division and the majority of biological pathways depends on the time of day in unicellular algae but we did not observe such patterns at the tissue level in multicellular land plants. Hence, our study provides evidence for the universality of diurnal gene expression and elucidates its evolutionary history among different photosynthetic eukaryotes.}, language = {en} } @article{ZhangChenSiemiatkowskaetal.2020, author = {Zhang, Youjun and Chen, Moxian and Siemiatkowska, Beata and Toleco, Mitchell Rey and Jing, Yue and Strotmann, Vivien and Zhang, Jianghua and Stahl, Yvonne and Fernie, Alisdair}, title = {A highly efficient agrobacterium-mediated method for transient gene expression and functional studies in multiple plant species}, series = {Plant Communications}, volume = {1}, journal = {Plant Communications}, number = {5}, publisher = {Science Direct}, address = {New York}, issn = {2590-3462}, pages = {12}, year = {2020}, abstract = {Although the use of stable transformation technology has led to great insight into gene function, its application in high-throughput studies remains arduous. Agro-infiltration have been widely used in species such as Nicotiana benthamiana for the rapid detection of gene expression and protein interaction analysis, but this technique does not work efficiently in other plant species, including Arabidopsis thaliana. As an efficient high-throughput transient expression system is currently lacking in the model plant species A. thaliana, we developed a method that is characterized by high efficiency, reproducibility, and suitability for transient expression of a variety of functional proteins in A. thaliana and 7 other plant species, including Brassica oleracea, Capsella rubella, Thellungiella salsuginea, Thellungiella halophila, Solanum tuberosum, Capsicum annuum, and N. benthamiana. Efficiency of this method was independently verified in three independent research facilities, pointing to the robustness of this technique. Furthermore, in addition to demonstrating the utility of this technique in a range of species, we also present a case study employing this method to assess protein-protein interactions in the sucrose biosynthesis pathway in Arabidopsis.}, language = {en} } @article{PandeyYuOmranianetal.2019, author = {Pandey, Prashant K. and Yu, Jing and Omranian, Nooshin and Alseekh, Saleh and Vaid, Neha and Fernie, Alisdair and Nikoloski, Zoran and Laitinen, Roosa A. E.}, title = {Plasticity in metabolism underpins local responses to nitrogen in Arabidopsis thaliana populations}, series = {Plant Direct}, volume = {3}, journal = {Plant Direct}, number = {11}, publisher = {John Wiley \& sonst LTD}, address = {Chichester}, issn = {2475-4455}, doi = {10.1002/pld3.186}, pages = {6}, year = {2019}, abstract = {Nitrogen (N) is central for plant growth, and metabolic plasticity can provide a strategy to respond to changing N availability. We showed that two local A. thaliana populations exhibited differential plasticity in the compounds of photorespiratory and starch degradation pathways in response to three N conditions. Association of metabolite levels with growth-related and fitness traits indicated that controlled plasticity in these pathways could contribute to local adaptation and play a role in plant evolution.}, language = {en} } @article{CordobaTongBurgosetal.2023, author = {C{\´o}rdoba, Sandra Correa and Tong, Hao and Burgos, Asdrubal and Zhu, Feng and Alseekh, Saleh and Fernie, Alisdair and Nikoloski, Zoran}, title = {Identification of gene function based on models capturing natural variability of Arabidopsis thaliana lipid metabolism}, series = {Nature Communications}, volume = {14}, journal = {Nature Communications}, number = {1}, publisher = {Springer Nature}, address = {London}, issn = {2041-1723}, doi = {10.1038/s41467-023-40644-9}, pages = {12}, year = {2023}, abstract = {The use of automated tools to reconstruct lipid metabolic pathways is not warranted in plants. Here, the authors construct Plant Lipid Module for Arabidopsis rosette using constraint-based modeling, demonstrate its integration in other plant metabolic models, and use it to dissect the genetic architecture of lipid metabolism. Lipids play fundamental roles in regulating agronomically important traits. Advances in plant lipid metabolism have until recently largely been based on reductionist approaches, although modulation of its components can have system-wide effects. However, existing models of plant lipid metabolism provide lumped representations, hindering detailed study of component modulation. Here, we present the Plant Lipid Module (PLM) which provides a mechanistic description of lipid metabolism in the Arabidopsis thaliana rosette. We demonstrate that the PLM can be readily integrated in models of A. thaliana Col-0 metabolism, yielding accurate predictions (83\%) of single lethal knock-outs and 75\% concordance between measured transcript and predicted flux changes under extended darkness. Genome-wide associations with fluxes obtained by integrating the PLM in diel condition- and accession-specific models identify up to 65 candidate genes modulating A. thaliana lipid metabolism. Using mutant lines, we validate up to 40\% of the candidates, paving the way for identification of metabolic gene function based on models capturing natural variability in metabolism.}, language = {en} } @article{ApriyantoCompartZimmermannetal.2022, author = {Apriyanto, Ardha and Compart, Julia and Zimmermann, Vincent and Alseekh, Saleh and Fernie, Alisdair and Fettke, J{\"o}rg}, title = {Indication that starch and sucrose are biomarkers for oil yield in oil palm (Elaeis guineensis Jacq.)}, series = {Food chemistry}, volume = {393}, journal = {Food chemistry}, publisher = {Elsevier}, address = {New York, NY [u.a.]}, issn = {0308-8146}, doi = {10.1016/j.foodchem.2022.133361}, pages = {11}, year = {2022}, abstract = {Oil palm (Elaeis guineensis Jacq.) is the most productive oil-producing crop per hectare of land. The oil that accumulates in the mesocarp tissue of the fruit is the highest observed among fruit-producing plants. A comparative analysis between high-, medium-, and low-yielding oil palms, particularly during fruit development, revealed unique characteristics. Metabolomics analysis was able to distinguish accumulation patterns defining of the various developmental stages and oil yield. Interestingly, high- and medium-yielding oil palms exhibited substantially increased sucrose levels compared to low-yielding palms. In addition, parameters such as starch granule morphology, granule size, total starch content, and starch chain length distribution (CLD) differed significantly among the oil yield categories with a clear correlation between oil yield and various starch parameters. These results provide new insights into carbohydrate and starch metabolism for biosynthesis of oil palm fruits, indicating that starch and sucrose can be used as novel, easy-to-analyze, and reliable biomarker for oil yield.}, language = {en} } @article{WatanabeTohgeBalazadehetal.2018, author = {Watanabe, Mutsumi and Tohge, Takayuki and Balazadeh, Salma and Erban, Alexander and Giavalisco, Patrick and Kopka, Joachim and Mueller-Roeber, Bernd and Fernie, Alisdair and Hoefgen, Rainer}, title = {Comprehensive Metabolomics Studies of Plant Developmental Senescence}, series = {Plant Senescence: Methods and Protocols}, volume = {1744}, journal = {Plant Senescence: Methods and Protocols}, publisher = {Humana Press}, address = {Totowa}, isbn = {978-1-4939-7672-0}, issn = {1064-3745}, doi = {10.1007/978-1-4939-7672-0_28}, pages = {339 -- 358}, year = {2018}, abstract = {Leaf senescence is an essential developmental process that involves diverse metabolic changes associated with degradation of macromolecules allowing nutrient recycling and remobilization. In contrast to the significant progress in transcriptomic analysis of leaf senescence, metabolomics analyses have been relatively limited. A broad overview of metabolic changes during leaf senescence including the interactions between various metabolic pathways is required to gain a better understanding of the leaf senescence allowing to link transcriptomics with metabolomics and physiology. In this chapter, we describe how to obtain comprehensive metabolite profiles and how to dissect metabolic shifts during leaf senescence in the model plant Arabidopsis thaliana. Unlike nucleic acid analysis for transcriptomics, a comprehensive metabolite profile can only be achieved by combining a suite of analytic tools. Here, information is provided for measurements of the contents of chlorophyll, soluble proteins, and starch by spectrophotometric methods, ions by ion chromatography, thiols and amino acids by HPLC, primary metabolites by GC/TOF-MS, and secondary metabolites and lipophilic metabolites by LC/ESI-MS. These metabolite profiles provide a rich catalogue of metabolic changes during leaf senescence, which is a helpful database and blueprint to be correlated to future studies such as transcriptome and proteome analyses, forward and reverse genetic studies, or stress-induced senescence studies.}, language = {en} } @article{LangusHoehle2021, author = {Langus, Alan and H{\"o}hle, Barbara}, title = {Object individuation and labelling in 6-month-old infants}, series = {Infant behavior \& development}, volume = {65}, journal = {Infant behavior \& development}, publisher = {Elsevier}, address = {New York}, issn = {0163-6383}, doi = {10.1016/j.infbeh.2021.101627}, pages = {12}, year = {2021}, abstract = {The ability to determine how many objects are involved in physical events is fundamental for reasoning about the world that surrounds us. Previous studies suggest that infants can fail to individuate objects in ambiguous occlusion events until their first birthday and that learning words for the objects may play a crucial role in the development of this ability. The present eye-tracking study tested whether the classical object individuation experiments underestimate young infants' ability to individuate objects and the role word learning plays in this process. Three groups of 6-month-old infants (N = 72) saw two opaque boxes side by side on the eye-tracker screen so that the content of the boxes was not visible. During a familiarization phase, two visually identical objects emerged sequentially from one box and two visually different objects from the other box. For one group of infants the familiarization was silent (Visual Only condition). For a second group of infants the objects were accompanied with nonsense words so that objects' shape and linguistic labels indicated the same number of objects in the two boxes (Visual \& Language condition). For the third group of infants, objects' shape and linguistic labels were in conflict (Visual vs. Language condition). Following the familiarization, it was revealed that both boxes contained the same number of objects (e.g. one or two). In the Visual Only condition, infants looked longer to the box with incorrect number of objects at test, showing that they could individuate objects using visual cues alone. In the Visual \& Language condition infants showed the same looking pattern. However, in the Visual vs Language condition infants looked longer to the box with incorrect number of objects according to linguistic labels. The results show that infants can individuate objects in a complex object individuation paradigm considerably earlier than previously thought and that linguistic cues enforce their own preference in object individuation. The results are consistent with the idea that when language and visual information are in conflict, language can exert an influence on how young infants reason about the visual world.}, language = {en} } @article{MarimonTarterHoehleLangus2022, author = {Marimon Tarter, Mireia and H{\"o}hle, Barbara and Langus, Alan}, title = {Pupillary entrainment reveals individual differences in cue weighting in 9-month-old German-learning infants}, series = {Cognition : international journal of cognitive science}, volume = {224}, journal = {Cognition : international journal of cognitive science}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0010-0277}, doi = {10.1016/j.cognition.2022.105054}, pages = {15}, year = {2022}, abstract = {Young infants can segment continuous speech with statistical as well as prosodic cues. Understanding how these cues interact can be informative about how infants solve the segmentation problem. Here we investigate how German-speaking adults and 9-month-old German-learning infants weigh statistical and prosodic cues when segmenting continuous speech. We measured participants' pupil size while they were familiarized with a continuous speech stream where prosodic cues were pitted off against transitional probabilities. Adult participants' changes in pupil size synchronized with the occurrence of prosodic words during the familiarization and the temporal alignment of these pupillary changes was predictive of adult participants' performance at test. Further, 9-month-olds as a group failed to consistently segment the familiarization stream with prosodic or statistical cues. However, the variability in temporal alignment of the pupillary changes at word frequency showed that prosodic and statistical cues compete for dominance when segmenting continuous speech. A followup language development questionnaire at 40 months of age suggested that infants who entrained to prosodic words performed better on a vocabulary task and those infants who relied more on statistical cues performed better on grammatical tasks. Together these results suggest that statistics and prosody may serve different roles in speech segmentation in infancy.}, language = {en} } @misc{NeubauerWankoSchaubetal.2017, author = {Neubauer, Kai and Wanko, Philipp and Schaub, Torsten and Haubelt, Christian}, title = {Enhancing symbolic system synthesis through ASPmT with partial assignment evaluation}, series = {Proceedings of the Design, Automation \& Test in Europe Conference \& Exhibition (DATE), 2017}, journal = {Proceedings of the Design, Automation \& Test in Europe Conference \& Exhibition (DATE), 2017}, publisher = {IEEE}, address = {New York}, isbn = {978-3-9815370-9-3}, issn = {1530-1591}, doi = {10.23919/DATE.2017.7927005}, pages = {306 -- 309}, year = {2017}, abstract = {The design of embedded systems is becoming continuously more complex such that efficient system-level design methods are becoming crucial. Recently, combined Answer Set Programming (ASP) and Quantifier Free Integer Difference Logic (QF-IDL) solving has been shown to be a promising approach in system synthesis. However, this approach still has several restrictions limiting its applicability. In the paper at hand, we propose a novel ASP modulo Theories (ASPmT) system synthesis approach, which (i) supports more sophisticated system models, (ii) tightly integrates the QF-IDL solving into the ASP solving, and (iii) makes use of partial assignment checking. As a result, more realistic systems are considered and an early exclusion of infeasible solutions improves the entire system synthesis.}, language = {en} } @article{GebserKaminskiKaufmannetal.2018, author = {Gebser, Martin and Kaminski, Roland and Kaufmann, Benjamin and L{\"u}hne, Patrick and Obermeier, Philipp and Ostrowski, Max and Romero Davila, Javier and Schaub, Torsten and Schellhorn, Sebastian and Wanko, Philipp}, title = {The Potsdam Answer Set Solving Collection 5.0}, series = {K{\"u}nstliche Intelligenz}, volume = {32}, journal = {K{\"u}nstliche Intelligenz}, number = {2-3}, publisher = {Springer}, address = {Heidelberg}, issn = {0933-1875}, doi = {10.1007/s13218-018-0528-x}, pages = {181 -- 182}, year = {2018}, abstract = {The Potsdam answer set solving collection, or Potassco for short, bundles various tools implementing and/or applying answer set programming. The article at hand succeeds an earlier description of the Potassco project published in Gebser et al. (AI Commun 24(2):107-124, 2011). Hence, we concentrate in what follows on the major features of the most recent, fifth generation of the ASP system clingo and highlight some recent resulting application systems.}, language = {en} } @article{HaubeltNeubauerSchaubetal.2018, author = {Haubelt, Christian and Neubauer, Kai and Schaub, Torsten and Wanko, Philipp}, title = {Design space exploration with answer set programming}, series = {K{\"u}nstliche Intelligenz}, volume = {32}, journal = {K{\"u}nstliche Intelligenz}, number = {2-3}, publisher = {Springer}, address = {Heidelberg}, issn = {0933-1875}, doi = {10.1007/s13218-018-0530-3}, pages = {205 -- 206}, year = {2018}, abstract = {The aim of our project design space exploration with answer set programming is to develop a general framework based on Answer Set Programming (ASP) that finds valid solutions to the system design problem and simultaneously performs Design Space Exploration (DSE) to find the most favorable alternatives. We leverage recent developments in ASP solving that allow for tight integration of background theories to create a holistic framework for effective DSE.}, language = {en} } @inproceedings{DennisInaebnit2021, author = {Dennis, Alice B. and In{\"a}bnit, Thomas}, title = {Physiological and genomic variation among cryptic species of a marsh snail (Melampus bidentatus)}, series = {Integrative and comparative biology / Society of Integrative and Comparative Biology}, volume = {61}, booktitle = {Integrative and comparative biology / Society of Integrative and Comparative Biology}, publisher = {Oxford University Press}, address = {Oxford}, issn = {1540-7063}, doi = {10.1093/icb/icab001}, pages = {E195 -- E196}, year = {2021}, language = {en} } @article{DettmannHuittinenNicolasetal.2023, author = {Dettmann, Sophie and Huittinen, Nina Maria and Nicolas, Jahn and Kretzschmar, Jerome and Kumke, Michael Uwe and Kutyma, Tamara and Lohmann, Janik and Reich, Tobias and Schmeide, Katja and Azzam, Salim Shams Aldin and Spittler, Leon and Stietz, Janina}, title = {Influence of gluconate on the retention of Eu(III), Am(III), Th(IV), Pu(IV), and U(VI) by C-S-H (C/S = 0.8)}, series = {Frontiers in Nuclear Engineering}, volume = {2}, journal = {Frontiers in Nuclear Engineering}, publisher = {Frontiers Media}, address = {Lausanne}, issn = {2813-3412}, doi = {10.3389/fnuen.2023.1124856}, pages = {15}, year = {2023}, abstract = {The retention of actinides in different oxidation states (An(X), X = III, IV, VI) by a calcium-silicate-hydrate (C-S-H) phase with a Ca/Si (C/S) ratio of 0.8 was investigated in the presence of gluconate (GLU). The actinides considered were Am(III), Th(IV), Pu(IV), and U(VI). Eu(III) was investigated as chemical analogue for Am(III) and Cm(III). In addition to the ternary systems An(X)/GLU/C-S-H, also binary systems An(X)/C-S-H, GLU/C-S-H, and An(X)/GLU were studied. Complementary analytical techniques were applied to address the different specific aspects of the binary and ternary systems. Time-resolved laser-induced luminescence spectroscopy (TRLFS) was applied in combination with parallel factor analysis (PARAFAC) to identify retained species and to monitor species-selective sorption kinetics. ¹³C and ²⁹Si magic-angle-spinning (MAS) nuclear magnetic resonance (NMR) spectroscopy and X-ray photoelectron spectroscopy (XPS) were applied to determine the bulk structure and the composition of the C-S-H surface, respectively, in the absence and presence of GLU. The interaction of Th(IV) with GLU in different electrolytes was studied by capillary electrophoresis-inductively coupled plasma mass spectrometry (CE-ICP-MS). The influence of GLU on An(X) retention was investigated for a large concentration range up to 10⁻² M. The results showed that GLU had little to no effect on the overall An(X) retention by C-S-H with C/S of 0.8, regardless of the oxidation state of the actinides. For Eu(III), the TRLFS investigations additionally implied the formation of a Eu(III)-bearing precipitate with dissolved constituents of the C-S-H phase, which becomes structurally altered by the presence of GLU. For U(VI) sorption on the C-S-H phase, only a small influence of GLU could be established in the luminescence spectroscopic investigations, and no precipitation of U(VI)-containing secondary phases could be identified.}, language = {en} } @article{ToenjesFiorePereiradaSilva2021, author = {T{\"o}njes, Ralf and Fiore, Carlos E. and Pereira da Silva, Tiago}, title = {Coherence resonance in influencer networks}, series = {Nature Communications}, volume = {12}, journal = {Nature Communications}, number = {1}, publisher = {Nature Publishing Group UK}, address = {London}, issn = {2041-1723}, doi = {10.1038/s41467-020-20441-4}, pages = {8}, year = {2021}, abstract = {Complex networks are abundant in nature and many share an important structural property: they contain a few nodes that are abnormally highly connected (hubs). Some of these hubs are called influencers because they couple strongly to the network and play fundamental dynamical and structural roles. Strikingly, despite the abundance of networks with influencers, little is known about their response to stochastic forcing. Here, for oscillatory dynamics on influencer networks, we show that subjecting influencers to an optimal intensity of noise can result in enhanced network synchronization. This new network dynamical effect, which we call coherence resonance in influencer networks, emerges from a synergy between network structure and stochasticity and is highly nonlinear, vanishing when the noise is too weak or too strong. Our results reveal that the influencer backbone can sharply increase the dynamical response in complex systems of coupled oscillators. Influencer networks include a small set of highly-connected nodes and can reach synchrony only via strong node interaction. Tonjes et al. show that introducing an optimal amount of noise enhances synchronization of such networks, which may be relevant for neuroscience or opinion dynamics applications.}, language = {en} } @article{ToenjesKori2022, author = {T{\"o}njes, Ralf and Kori, Hiroshi}, title = {Phase and frequency linear response theory for hyperbolic chaotic oscillators}, series = {Chaos : an interdisciplinary journal of nonlinear science}, volume = {32}, journal = {Chaos : an interdisciplinary journal of nonlinear science}, number = {4}, publisher = {AIP Publishing}, address = {Melville}, issn = {1054-1500}, doi = {10.1063/5.0064519}, pages = {13}, year = {2022}, abstract = {We formulate a linear phase and frequency response theory for hyperbolic flows, which generalizes phase response theory for autonomous limit cycle oscillators to hyperbolic chaotic dynamics. The theory is based on a shadowing conjecture, stating the existence of a perturbed trajectory shadowing every unperturbed trajectory on the system attractor for any small enough perturbation of arbitrary duration and a corresponding unique time isomorphism, which we identify as phase such that phase shifts between the unperturbed trajectory and its perturbed shadow are well defined. The phase sensitivity function is the solution of an adjoint linear equation and can be used to estimate the average change of phase velocity to small time dependent or independent perturbations. These changes in frequency are experimentally accessible, giving a convenient way to define and measure phase response curves for chaotic oscillators. The shadowing trajectory and the phase can be constructed explicitly in the tangent space of an unperturbed trajectory using co-variant Lyapunov vectors. It can also be used to identify the limits of the regime of linear response.}, language = {en} } @article{ZhengToenjesPikovskij2021, author = {Zheng, Chunming and T{\"o}njes, Ralf and Pikovskij, Arkadij}, title = {Transition to synchrony in a three-dimensional swarming model with helical trajectories}, series = {Physical review : E, Statistical, nonlinear and soft matter physics}, volume = {104}, journal = {Physical review : E, Statistical, nonlinear and soft matter physics}, number = {1}, publisher = {American Physical Society}, address = {College Park}, issn = {2470-0045}, doi = {10.1103/PhysRevE.104.014216}, pages = {7}, year = {2021}, abstract = {We investigate the transition from incoherence to global collective motion in a three-dimensional swarming model of agents with helical trajectories, subject to noise and global coupling. Without noise this model was recently proposed as a generalization of the Kuramoto model and it was found that alignment of the velocities occurs discontinuously for arbitrarily small attractive coupling. Adding noise to the system resolves this singular limit and leads to a continuous transition, either to a directed collective motion or to center-of-mass rotations.}, language = {en} } @article{ToenjesPikovsky2020, author = {T{\"o}njes, Ralf and Pikovsky, Arkady}, title = {Low-dimensional description for ensembles of identical phase oscillators subject to Cauchy noise}, series = {Physical review : E, Statistical, nonlinear and soft matter physics}, volume = {102}, journal = {Physical review : E, Statistical, nonlinear and soft matter physics}, number = {5}, publisher = {American Physical Society}, address = {College Park}, issn = {2470-0045}, doi = {10.1103/PhysRevE.102.052315}, pages = {5}, year = {2020}, abstract = {We study ensembles of globally coupled or forced identical phase oscillators subject to independent white Cauchy noise. We demonstrate that if the oscillators are forced in several harmonics, stationary synchronous regimes can be exactly described with a finite number of complex order parameters. The corresponding distribution of phases is a product of wrapped Cauchy distributions. For sinusoidal forcing, the Ott-Antonsen low-dimensional reduction is recovered.}, language = {en} } @article{Mitsch2023, author = {Mitsch, Wolfgang}, title = {Warum \S 362 Nr. 5 StPO aufgehoben werden sollte}, series = {KriPoZ : kriminalpolitische Zeitschrift}, volume = {8}, journal = {KriPoZ : kriminalpolitische Zeitschrift}, number = {5}, publisher = {Universit{\"a}t zu K{\"o}ln}, address = {K{\"o}ln}, issn = {2509-6826}, pages = {371 -- 378}, year = {2023}, abstract = {Mit Spannung wird die Entscheidung des BVerfG zu \S 362 Nr. 5 StPO erwartet. Die Verfassungsbeschwerde des Beschuldigten, der vor Jahrzehnten vom Vorwurf des Mordes rechtskr{\"a}ftig freigesprochen worden war und der nun bef{\"u}rchten muss, auf der Grundlage des \S 362 Nr. 5 StPO wegen derselben Tat verurteilt zu werden, hat die verfassungsrechtliche {\"U}berpr{\"u}fung der Vorschrift veranlasst. Zuvor waren bereits in zahlreichen Texten von Rechtswissenschaftlern Argumente f{\"u}r und gegen die Regelung ausgetauscht worden. Verst{\"a}ndlicherweise steht dabei Art. 103 Abs. 3 GG im Vordergrund. Wer \S 362 Nr. 5 StPO ablehnt, begr{\"u}ndet das in erster Linie mit einer Verletzung des ne-bis-in-idem-Grundsatzes. Nicht wenige Bef{\"u}rworter der erweiterten Wiederaufnahmem{\"o}glichkeit verweisen - gef{\"u}hlsgeleitet - auf „materielle Gerechtigkeit" sowie auf „schlechterdings unertr{\"a}gliche Ergebnisse". Unbefriedigend ist das f{\"u}r Menschen, die es weder ungerecht noch unertr{\"a}glich finden, dass ein Tatverd{\"a}chtiger nach rechtskr{\"a}ftigem Freispruch bis an sein Lebensende als „unschuldig" gilt und zwar auch, wenn auf Grund neuer Beweismittel aus dem Freigesprochenen ein zu lebenslanger Freiheitsstrafe Verurteilter werden k{\"o}nnte. Dass das Festhalten am rechtskr{\"a}ftigen Freispruch richtig ist, daf{\"u}r gibt es starke juristische Gr{\"u}nde. Auch f{\"u}r die Durchbrechung des Strafklageverbrauchs in den von \S 362 Nr. 5 StPO erfassten F{\"a}llen gibt es gewiss beachtliche Gr{\"u}nde. Sie sind meines Erachtens jedoch nicht gewichtig genug. Im vorliegenden Text soll die verfassungsrechtliche Dimension außen vor bleiben. Eine neue Vorschrift, mit der das geltende Strafprozessrecht ver{\"a}ndert wird, muss auch eine Pr{\"u}fung am Maßstab des geltenden Strafprozessrechts durchlaufen, um akzeptiert werden zu k{\"o}nnen. \S 362 Nr. 5 StPO f{\"a}llt bei dieser Pr{\"u}fung durch und sollte deshalb aufgehoben werden.}, language = {de} } @article{Mitsch2024, author = {Mitsch, Wolfgang}, title = {Fortschritte im Notwehrrecht?}, series = {KriPoZ : kriminalpolitische Zeitschrift}, volume = {9}, journal = {KriPoZ : kriminalpolitische Zeitschrift}, number = {3}, publisher = {Universit{\"a}t zu K{\"o}ln}, address = {K{\"o}ln}, issn = {2509-6826}, pages = {148 -- 156}, year = {2024}, abstract = {Der untenstehende Text ist eine recht spontane Reaktion auf Bemerkungen, die j{\"u}ngst von den Kollegen Armin Engl{\"a}nder und Christian R{\"u}ckert zu einem Kodifizierungsvorschlag f{\"u}r die Regelungsthemen Notwehr, Notwehrexzess und subjektives Rechtfertigungselement in der Zeitschrift „Goltdammer's Archiv f{\"u}r Strafrecht" pr{\"a}sentiert wurden. Den Entwurfstext hat eine - kleine - Gruppe von Strafrechtslehrern erarbeitet. Er wurde letztes Jahr mittels eines Aufsatzes von Elisa Hoven und Wolfgang Mitsch - ebenfalls im „Goltdammer's Archiv" - vorgestellt und erl{\"a}utert. Engl{\"a}nder und R{\"u}ckert {\"a}ußern stellenweise Zustimmung, {\"u}ben aber auch zu vielen Punkten des Entwurfs und seiner Begr{\"u}ndung Kritik. Da der hiesige Verfasser sowohl an der Entwicklung des Entwurfstextes als auch an dem genannten GA-Aufsatz als Ko-Autor beteiligt war, m{\"o}chte er - im Folgenden: ich - zu einigen der Kritiken Stellung nehmen.}, language = {de} } @article{RinkerBloderPloetner2022, author = {Rinker, Tanja and Bloder, Theresa Sophie and Pl{\"o}tner, Kathleen}, title = {Italian and German lexical development in Italian heritage speakers in kindergarten and elementary school settings}, series = {Lingue e linguaggio / Dipartimento di Lingue}, volume = {21}, journal = {Lingue e linguaggio / Dipartimento di Lingue}, number = {1}, publisher = {Societ{\`a} editrice il Mulino}, address = {Bologna}, issn = {1720-9331}, doi = {10.1418/104449}, pages = {53 -- 72}, year = {2022}, abstract = {Language development in children with a heritage language background is often characterized by a shift towards the majority language once children enter formal educational contexts. In Germany, educational programs that target heritage languages are scarce. It is therefore of interest whether children with a heritage language background can benefit from a bilingual program targeting their heritage language. In this paper, we report data on the lexical skills of Italian heritage children in two educational contexts, bilingual Italian-German kindergartens and a bilingual Italian-German elementary school. We examine (1) developmental trajectories of children's lexical skills in German and Italian, (2) differences between noun and verb development, (3) differences between lexical production and comprehenand Italian, kindergarteners showed balanced receptive vocabulary skills. By contrast, elementary school-children had a larger German than Italian vocabulary. Both groups demonstrated a clear dominance of nouns over verbs. While school children already performed at ceiling in German at the end of first grade, across the school years, their Italian vocabulary increased, nouns in particular.}, language = {en} } @misc{DettmannHuittinenJahnetal.2023, author = {Dettmann, Sophie and Huittinen, Nina Maria and Jahn, Nicolas and Kretzschmar, Jerome and Kumke, Michael Uwe and Kutyma, Tamara and Lohmann, Janik and Reich, Tobias and Schmeide, Katja and Azzam, Salim Shams Aldin and Spittler, Leon and Stietz, Janina}, title = {Influence of gluconate on the retention of Eu(III), Am(III), Th(IV), Pu(IV), and U(VI) by C-S-H (C/S = 0.8)}, series = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, journal = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, number = {1318}, issn = {1866-8372}, doi = {10.25932/publishup-58845}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-588455}, pages = {15}, year = {2023}, abstract = {The retention of actinides in different oxidation states (An(X), X = III, IV, VI) by a calcium-silicate-hydrate (C-S-H) phase with a Ca/Si (C/S) ratio of 0.8 was investigated in the presence of gluconate (GLU). The actinides considered were Am(III), Th(IV), Pu(IV), and U(VI). Eu(III) was investigated as chemical analogue for Am(III) and Cm(III). In addition to the ternary systems An(X)/GLU/C-S-H, also binary systems An(X)/C-S-H, GLU/C-S-H, and An(X)/GLU were studied. Complementary analytical techniques were applied to address the different specific aspects of the binary and ternary systems. Time-resolved laser-induced luminescence spectroscopy (TRLFS) was applied in combination with parallel factor analysis (PARAFAC) to identify retained species and to monitor species-selective sorption kinetics. ¹³C and ²⁹Si magic-angle-spinning (MAS) nuclear magnetic resonance (NMR) spectroscopy and X-ray photoelectron spectroscopy (XPS) were applied to determine the bulk structure and the composition of the C-S-H surface, respectively, in the absence and presence of GLU. The interaction of Th(IV) with GLU in different electrolytes was studied by capillary electrophoresis-inductively coupled plasma mass spectrometry (CE-ICP-MS). The influence of GLU on An(X) retention was investigated for a large concentration range up to 10⁻² M. The results showed that GLU had little to no effect on the overall An(X) retention by C-S-H with C/S of 0.8, regardless of the oxidation state of the actinides. For Eu(III), the TRLFS investigations additionally implied the formation of a Eu(III)-bearing precipitate with dissolved constituents of the C-S-H phase, which becomes structurally altered by the presence of GLU. For U(VI) sorption on the C-S-H phase, only a small influence of GLU could be established in the luminescence spectroscopic investigations, and no precipitation of U(VI)-containing secondary phases could be identified.}, language = {en} } @article{ChemuraSchrumpfGuenteretal.2023, author = {Chemura, Sitshengisiwe and Schrumpf, Tim and G{\"u}nter, Christina and Kumke, Michael Uwe}, title = {Ceria nanomaterials containing ytterbium}, series = {RSC Advances : an international journal to further the chemical sciences}, volume = {13}, journal = {RSC Advances : an international journal to further the chemical sciences}, number = {50}, publisher = {RSC Publishing}, address = {London}, issn = {2046-2069}, doi = {10.1039/D3RA06868D}, pages = {35445 -- 35456}, year = {2023}, abstract = {Lanthanide based ceria nanomaterials are important practical materials due to the redox properties that are useful in the avenues pertaining to technology and life sciences. Sub 10 nm spherical and highly monodisperse Ce1-xYbxO2-y (0.04 ≤ x ≤ 0.22) nanoparticles were synthesized by thermal decomposition, annealed separately at 773 K and 1273 K for 2 hours and characterized. Elemental mapping for Yb3+ doped ceria nanoparticles shows homogeneous distribution of Yb3+ atoms in the ceria with low Yb3+ content annealed at 773 K and 1273 K for 2 hours. However, clusters are observed for 773 K annealed ceria samples with high concentration of Yb3+. These clusters are not detected in 1273 K annealed nanomaterials. Introducing small amounts of Yb3+ ions into the ceria lattice as spectroscopic probes can provide detailed information about the atomic structure and local environments allowing the monitoring of small structural changes, such as clustering. The emission spectra observed at room temperature and at 4 K have a manifold of bands that corresponds to the 2F5/2 → 2F7/2 transition of Yb3+ ions. Some small shifts are observed in the Stark splitting pattern depending on the sample and the annealing conditions. The deconvolution by PARAFAC analysis yielded luminescence decay kinetics as well as the associated luminescence spectra of three species for each of the low Yb3+ doped ceria samples annealed at 773 K and one species for the 1273 K annealed samples. However, the ceria samples with high concentration of Yb3+ annealed at the two temperatures showed only one species with lower decay times as compared to the low Yb3+ doped ceria samples.}, language = {en} } @article{BlasiusToenjes2005, author = {Blasius, Bernd and T{\"o}njes, Ralf}, title = {Quasiregular concentric waves in heterogeneous lattices of coupled oscillators}, year = {2005}, abstract = {We study the pattern formation in a lattice of locally coupled phase oscillators with quenched disorder. In the synchronized regime quasi regular concentric waves can arise which are induced by the disorder of the system. Maximal regularity is found at the edge of the synchronization regime. The emergence of the concentric waves is related to the symmetry breaking of the interaction function. An explanation of the numerically observed phenomena is given in a one- dimensional chain of coupled phase oscillators. Scaling properties, describing the target patterns are obtained.}, language = {en} } @article{GongZhengToenjesetal.2019, author = {Gong, Chen Chris and Zheng, Chunming and T{\"o}njes, Ralf and Pikovskij, Arkadij}, title = {Repulsively coupled Kuramoto-Sakaguchi phase oscillators ensemble subject to common noise}, series = {Chaos : an interdisciplinary journal of nonlinear science}, volume = {29}, journal = {Chaos : an interdisciplinary journal of nonlinear science}, number = {3}, publisher = {American Institute of Physics}, address = {Melville}, issn = {1054-1500}, doi = {10.1063/1.5084144}, pages = {11}, year = {2019}, abstract = {We consider the Kuramoto-Sakaguchi model of identical coupled phase oscillators with a common noisy forcing. While common noise always tends to synchronize the oscillators, a strong repulsive coupling prevents the fully synchronous state and leads to a nontrivial distribution of oscillator phases. In previous numerical simulations, the formation of stable multicluster states has been observed in this regime. However, we argue here that because identical phase oscillators in the Kuramoto-Sakaguchi model form a partially integrable system according to the Watanabe-Strogatz theory, the formation of clusters is impossible. Integrating with various time steps reveals that clustering is a numerical artifact, explained by the existence of higher order Fourier terms in the errors of the employed numerical integration schemes. By monitoring the induced change in certain integrals of motion, we quantify these errors. We support these observations by showing, on the basis of the analysis of the corresponding Fokker-Planck equation, that two-cluster states are non-attractive. On the other hand, in ensembles of general limit cycle oscillators, such as Van der Pol oscillators, due to an anharmonic phase response function as well as additional amplitude dynamics, multiclusters can occur naturally. Published under license by AIP Publishing.}, language = {en} } @article{GongToenjesPikovsky2020, author = {Gong, Chen Chris and T{\"o}njes, Ralf and Pikovsky, Arkady}, title = {Coupled M{\"o}bius maps as a tool to model Kuramoto phase synchronization}, series = {Physical review : E, Statistical, nonlinear and soft matter physics}, volume = {102}, journal = {Physical review : E, Statistical, nonlinear and soft matter physics}, number = {2}, publisher = {American Physical Society}, address = {College Park}, issn = {2470-0045}, doi = {10.1103/PhysRevE.102.022206}, pages = {12}, year = {2020}, abstract = {We propose Mobius maps as a tool to model synchronization phenomena in coupled phase oscillators. Not only does the map provide fast computation of phase synchronization, it also reflects the underlying group structure of the sinusoidally coupled continuous phase dynamics. We study map versions of various known continuous-time collective dynamics, such as the synchronization transition in the Kuramoto-Sakaguchi model of nonidentical oscillators, chimeras in two coupled populations of identical phase oscillators, and Kuramoto-Battogtokh chimeras on a ring, and demonstrate similarities and differences between the iterated map models and their known continuous-time counterparts.}, language = {en} } @article{ToenjesBlasius2009, author = {T{\"o}njes, Ralf and Blasius, Bernd}, title = {Perturbation analysis of the Kuramoto phase-diffusion equation subject to quenched frequency disorder}, issn = {1539-3755}, doi = {10.1103/Physreve.79.016112}, year = {2009}, abstract = {The Kuramoto phase-diffusion equation is a nonlinear partial differential equation which describes the spatiotemporal evolution of a phase variable in an oscillatory reaction-diffusion system. Synchronization manifests itself in a stationary phase gradient where all phases throughout a system evolve with the same velocity, the synchronization frequency. The formation of concentric waves can be explained by local impurities of higher frequency which can entrain their surroundings. Concentric waves in synchronization also occur in heterogeneous systems, where the local frequencies are distributed randomly. We present a perturbation analysis of the synchronization frequency where the perturbation is given by the heterogeneity of natural frequencies in the system. The nonlinearity in the form of dispersion leads to an overall acceleration of the oscillation for which the expected value can be calculated from the second-order perturbation terms. We apply the theory to simple topologies, like a line or sphere, and deduce the dependence of the synchronization frequency on the size and the dimension of the oscillatory medium. We show that our theory can be extended to include rotating waves in a medium with periodic boundary conditions. By changing a system parameter, the synchronized state may become quasidegenerate. We demonstrate how perturbation theory fails at such a critical point.}, language = {en} } @article{ToenjesSokolovPostnikov2013, author = {T{\"o}njes, Ralf and Sokolov, Igor M. and Postnikov, E. B.}, title = {Non-spectral relaxation in one dimensional Ornstein-Uhlenbeck processes}, series = {Physical review letters}, volume = {110}, journal = {Physical review letters}, number = {15}, publisher = {American Physical Society}, address = {College Park}, issn = {0031-9007}, doi = {10.1103/PhysRevLett.110.150602}, pages = {4}, year = {2013}, abstract = {The relaxation of a dissipative system to its equilibrium state often shows a multiexponential pattern with relaxation rates, which are typically considered to be independent of the initial condition. The rates follow from the spectrum of a Hermitian operator obtained by a similarity transformation of the initial Fokker-Planck operator. However, some initial conditions are mapped by this similarity transformation to functions which growat infinity. These cannot be expanded in terms of the eigenfunctions of a Hermitian operator, and show different relaxation patterns. Considering the exactly solvable examples of Gaussian and generalized Levy Ornstein-Uhlenbeck processes (OUPs) we show that the relaxation rates belong to the Hermitian spectrum only if the initial condition belongs to the domain of attraction of the stable distribution defining the noise. While for an ordinary OUP initial conditions leading to nonspectral relaxation can be considered exotic, for generalized OUPs driven by Levy noise, such initial conditions are the rule. DOI: 10.1103/PhysRevLett.110.150602}, language = {en} } @article{SebekToenjesKiss2016, author = {Sebek, Michael and T{\"o}njes, Ralf and Kiss, Istvan Z.}, title = {Complex Rotating Waves and Long Transients in a Ring Network of Electrochemical Oscillators with Sparse Random Cross-Connections}, series = {Physical review letters}, volume = {116}, journal = {Physical review letters}, publisher = {American Physical Society}, address = {College Park}, issn = {0031-9007}, doi = {10.1103/PhysRevLett.116.068701}, pages = {3001 -- 3009}, year = {2016}, abstract = {We perform experiments and phase model simulations with a ring network of oscillatory electrochemical reactions to explore the effect of random connections and nonisochronicity of the interactions on the pattern formation. A few additional links facilitate the emergence of the fully synchronized state. With larger nonisochronicity, complex rotating waves or persistent irregular phase dynamics can derail the convergence to global synchronization. The observed long transients of irregular phase dynamics exemplify the possibility of a sudden onset of hypersynchronous behavior without any external stimulus or network reorganization.}, language = {en} } @article{ToenjesSokolovPostnikov2014, author = {T{\"o}njes, Ralf and Sokolov, Igor M. and Postnikov, Eugene B.}, title = {Spectral properties of the fractional Fokker-Planck operator for the Levy flight in a harmonic potential}, series = {The European physical journal}, volume = {87}, journal = {The European physical journal}, number = {12}, publisher = {Springer}, address = {New York}, issn = {1434-6028}, doi = {10.1140/epjb/e2014-50558-5}, pages = {11}, year = {2014}, abstract = {We present a detailed analysis of the eigenfunctions of the Fokker-Planck operator for the LevyOrnstein- Uhlenbeck process, their asymptotic behavior and recurrence relations, explicit expressions in coordinate space for the special cases of the Ornstein-Uhlenbeck process with Gaussian and with Cauchy white noise and for the transformation kernel, which maps the fractional Fokker-Planck operator of the Cauchy-Ornstein-Uhlenbeck process to the non-fractional Fokker-Planck operator of the usual Gaussian Ornstein-Uhlenbeck process. We also describe how non-spectral relaxation can be observed in bounded random variables of the Levy-Ornstein-Uhlenbeck process and their correlation functions.}, language = {en} } @article{ToenjesBlasius2009, author = {T{\"o}njes, Ralf and Blasius, Bernd}, title = {Perturbation analysis of complete synchronization in networks of phase oscillators}, issn = {1539-3755}, doi = {10.1103/Physreve.80.026202}, year = {2009}, abstract = {The behavior of weakly coupled self-sustained oscillators can often be well described by phase equations. Here we use the paradigm of Kuramoto phase oscillators which are coupled in a network to calculate first- and second-order corrections to the frequency of the fully synchronized state for nonidentical oscillators. The topology of the underlying coupling network is reflected in the eigenvalues and eigenvectors of the network Laplacian which influence the synchronization frequency in a particular way. They characterize the importance of nodes in a network and the relations between them. Expected values for the synchronization frequency are obtained for oscillators with quenched random frequencies on a class of scale-free random networks and for a Erdoumls-Reacutenyi random network. We briefly discuss an application of the perturbation theory in the second order to network structural analysis.}, language = {en} } @article{BlasiusToenjes2009, author = {Blasius, Bernd and T{\"o}njes, Ralf}, title = {Zipf's Law in the popularity distribution of chess openings}, issn = {0031-9007}, doi = {10.1103/Physrevlett.103.218701}, year = {2009}, abstract = {We perform a quantitative analysis of extensive chess databases and show that the frequencies of opening moves are distributed according to a power law with an exponent that increases linearly with the game depth, whereas the pooled distribution of all opening weights follows Zipf's law with universal exponent. We propose a simple stochastic process that is able to capture the observed playing statistics and show that the Zipf law arises from the self-similar nature of the game tree of chess. Thus, in the case of hierarchical fragmentation the scaling is truly universal and independent of a particular generating mechanism. Our findings are of relevance in general processes with composite decisions.}, language = {en} } @article{OezsoyIefremenkoSchroeder2022, author = {{\"O}zsoy, Onur and Iefremenko, Kateryna and Schroeder, Christoph}, title = {Shifting and expanding clause combining strategies in heritage Turkish varieties}, series = {Languages}, volume = {7}, journal = {Languages}, number = {3}, publisher = {MDPI}, address = {Basel}, issn = {2226-471X}, doi = {10.3390/languages7030242}, pages = {23}, year = {2022}, abstract = {Turkish is a language described as relying predominantly on non-finite subordination in the domain of clause combining. However, there are also strategies of finite subordination, as well as means of syndetic and asyndetic paratactic clause combining, especially in the informal settings. Clause combining is and has been one of the focal points of research on heritage Turkish (h-Turkish). One point is particularly clear: In comparison with the monolingual setting, finite means of clause combining are more frequent in h-Turkish in Germany, the U.S., and the Netherlands, while non-finite means of clause combining are less frequent. Overall, our results confirm the findings of earlier studies: heritage speakers in Germany and the U.S. prefer paratactic means of clause combining using connectors, as opposed to monolingual speakers. Our results also reveal that age (adolescents vs. adults) and register (informal vs. formal) significantly modulate the use of connectors. Moreover, we find that the shift in preferences in means of clause combining triggers an expansion in the system of connectors and leads to the development of new narrative connectors, such as o zaman and derken. The system of syndetic paratactic clause combining is expanding in heritage Turkish. This expansion calls for multifaceted modeling of change in heritage languages, which integrates language-internal factors (register), dynamics of convergence with the contact languages, and extra-linguistic factors (age and language use).}, language = {en} } @article{AngerChristophGalkiewiczetal.2024, author = {Anger, Silke and Christoph, Bernhard and Galkiewicz, Agata and Margaryan, Shushanik and Peter, Frauke and Sandner, Malte and Siedler, Thomas}, title = {War, international spillovers, and adolescents}, series = {Journal of Economic Behavior \& Organization}, volume = {224}, journal = {Journal of Economic Behavior \& Organization}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0167-2681}, doi = {10.1016/j.jebo.2024.03.009}, pages = {181 -- 193}, year = {2024}, abstract = {Using novel longitudinal data, this paper studies the short- and medium-term effects of Russia's invasion of Ukraine on February 24, 2022 on social trust of adolescents in Germany. Comparing adolescents who responded to our survey shortly before the start of the war with those who responded shortly after the conflict began and applying difference-in-differences (DiD) models over time, we find a significant decline in the outcome after the war started. These findings provide new evidence on how armed conflicts influence social trust and well-being among young people in a country not directly involved in the war.}, language = {en} } @article{Krueger2022, author = {Kr{\"u}ger, Hans-Peter}, title = {Critical anthropology? On the relation between philosophical anthropology and critical theory}, series = {Iride : filosofia e discussione pubblica}, volume = {35}, journal = {Iride : filosofia e discussione pubblica}, number = {2}, publisher = {Societ{\`a} editrice il Mulino}, address = {Bologna}, isbn = {978-88-15-38060-9}, issn = {1122-7893}, doi = {10.1414/106105}, pages = {313 -- 331}, year = {2022}, abstract = {This article compares Max Horkheimer's and Theodor W. Adorno's foundation of the Frankfurt Critical Theory with Helmuth Plessner's foundation of Philosophical Anthropology. While Horkheimer's and Plessner's paradigms are mutually incompatible, Adorno's << negative dialectics >> and Plessner's << negative anthropology >> (G. Gamm) can be seen as complementing one another. Jurgen Habermas at one point sketched a complementary relationship between his own publicly communicative theory of modern society and Plessner's philosophy of nature and human expressivity, and though he then came to doubt this, he later reaffirmed it. Faced with the << life power >> in << high capitalism >> (Plessner), the ambitions for a public democracy in a pluralistic society have to be broadened from an argumentative focus (Habermas) to include the human condition and the expressive modes of our experience as essentially embodied persons. The article discusses some possible aspects of this complementarity under the title of a << critical anthropology >> (H. Schn{\"a}delbach).}, language = {en} } @article{RiehlSchroeder2022, author = {Riehl, Claudia Maria and Schroeder, Christoph}, title = {DaF / DaZ im Kontext von Mehrsprachigkeit}, series = {Deutsch als Fremdsprache : Zeitschrift zur Theorie und Praxis des Faches Deutsch als Fremdsprache}, volume = {59}, journal = {Deutsch als Fremdsprache : Zeitschrift zur Theorie und Praxis des Faches Deutsch als Fremdsprache}, number = {2}, publisher = {Erich Schmidt Verlag}, address = {Berlin}, issn = {0011-9741}, doi = {10.37307/j.2198-2430.2022.02}, pages = {67 -- 76}, year = {2022}, abstract = {Der Beitrag beleuchtet die Perspektiven von DaF und DaZ im Kontext von Mehrsprachigkeit. Zun{\"a}chst wird ein Verst{\"a}ndnis von ‚Mehrsprachigkeitʻ erarbeitet und diskutiert. Anschließend wird gezeigt, wie sich DaZ, DaF und die Forschung zu Variet{\"a}ten des Deutschen im Ausland im Rahmen dieses Verst{\"a}ndnisses von Mehrsprachigkeit positionieren lassen. Der Beitrag schließt mit einem Pl{\"a}doyer f{\"u}r ein neues, integratives Konzept von ‚Deutsch im Mehrsprachigkeitskontextʻ.}, language = {de} } @article{WenderingNikoloski2022, author = {Wendering, Philipp and Nikoloski, Zoran}, title = {Genome-scale modeling specifies the metabolic capabilities of Rhizophagus irregularis}, series = {mSystems}, volume = {7}, journal = {mSystems}, number = {1}, publisher = {American Society for Microbiology}, address = {Washington, DC}, issn = {2379-5077}, doi = {10.1128/msystems.01216-21}, pages = {17}, year = {2022}, abstract = {Rhizophagus irregularis is one of the most extensively studied arbuscular mycorrhizal fungi (AMF) that forms symbioses with and improves the performance of many crops. Lack of transformation protocol for R. irregularis renders it challenging to investigate molecular mechanisms that shape the physiology and interactions of this AMF with plants. Here, we used all published genomics, transcriptomics, and metabolomics resources to gain insights into the metabolic functionalities of R. irregularis by reconstructing its high-quality genome-scale metabolic network that considers enzyme constraints. Extensive validation tests with the enzyme-constrained metabolic model demonstrated that it can be used to (i) accurately predict increased growth of R. irregularis on myristate with minimal medium; (ii) integrate enzyme abundances and carbon source concentrations that yield growth predictions with high and significant Spearman correlation (rS = 0.74) to measured hyphal dry weight; and (iii) simulate growth rate increases with tighter association of this AMF with the host plant across three fungal structures. Based on the validated model and system-level analyses that integrate data from transcriptomics studies, we predicted that differences in flux distributions between intraradical mycelium and arbuscles are linked to changes in amino acid and cofactor biosynthesis. Therefore, our results demonstrated that the enzyme-constrained metabolic model can be employed to pinpoint mechanisms driving developmental and physiological responses of R. irregularis to different environmental cues. In conclusion, this model can serve as a template for other AMF and paves the way to identify metabolic engineering strategies to modulate fungal metabolic traits that directly affect plant performance. IMPORTANCE Mounting evidence points to the benefits of the symbiotic interactions between the arbuscular mycorrhiza fungus Rhizophagus irregularis and crops; however, the molecular mechanisms underlying the physiological responses of this fungus to different host plants and environments remain largely unknown. We present a manually curated, enzyme-constrained, genome-scale metabolic model of R. irregularis that can accurately predict experimentally observed phenotypes. We show that this high-quality model provides an entry point into better understanding the metabolic and physiological responses of this fungus to changing environments due to the availability of different nutrients. The model can be used to design metabolic engineering strategies to tailor R. irregularis metabolism toward improving the performance of host plants.}, language = {en} } @inproceedings{FayyazHartmannHanacketal.2022, author = {Fayyaz, Susann and Hartmann, Bolette and Hanack, Katja and Michelchen, Sophia and Kreiling, Reinhard}, title = {Development of a hematopoietic stem cell (murine system) based system as an alternative for the in vivo T-cell-dependent antibody response (TDAR) assay within the EOGRTS: case-study with Parabens}, series = {Toxicology letters}, volume = {368}, booktitle = {Toxicology letters}, publisher = {Elsevier Science}, address = {Amsterdam [u.a.]}, issn = {0378-4274}, doi = {10.1016/j.toxlet.2022.07.483}, pages = {S175 -- S176}, year = {2022}, language = {en} } @article{HuangHuangReichetal.2022, author = {Huang, Daniel Zhengyu and Huang, Jiaoyang and Reich, Sebastian and Stuart, Andrew M.}, title = {Efficient derivative-free Bayesian inference for large-scale inverse problems}, series = {Inverse problems : an international journal of inverse problems, inverse methods and computerised inversion of data}, volume = {38}, journal = {Inverse problems : an international journal of inverse problems, inverse methods and computerised inversion of data}, number = {12}, publisher = {IOP Publ. Ltd.}, address = {Bristol}, issn = {0266-5611}, doi = {10.1088/1361-6420/ac99fa}, pages = {40}, year = {2022}, abstract = {We consider Bayesian inference for large-scale inverse problems, where computational challenges arise from the need for repeated evaluations of an expensive forward model. This renders most Markov chain Monte Carlo approaches infeasible, since they typically require O(10(4)) model runs, or more. Moreover, the forward model is often given as a black box or is impractical to differentiate. Therefore derivative-free algorithms are highly desirable. We propose a framework, which is built on Kalman methodology, to efficiently perform Bayesian inference in such inverse problems. The basic method is based on an approximation of the filtering distribution of a novel mean-field dynamical system, into which the inverse problem is embedded as an observation operator. Theoretical properties are established for linear inverse problems, demonstrating that the desired Bayesian posterior is given by the steady state of the law of the filtering distribution of the mean-field dynamical system, and proving exponential convergence to it. This suggests that, for nonlinear problems which are close to Gaussian, sequentially computing this law provides the basis for efficient iterative methods to approximate the Bayesian posterior. Ensemble methods are applied to obtain interacting particle system approximations of the filtering distribution of the mean-field model; and practical strategies to further reduce the computational and memory cost of the methodology are presented, including low-rank approximation and a bi-fidelity approach. The effectiveness of the framework is demonstrated in several numerical experiments, including proof-of-concept linear/nonlinear examples and two large-scale applications: learning of permeability parameters in subsurface flow; and learning subgrid-scale parameters in a global climate model. Moreover, the stochastic ensemble Kalman filter and various ensemble square-root Kalman filters are all employed and are compared numerically. The results demonstrate that the proposed method, based on exponential convergence to the filtering distribution of a mean-field dynamical system, is competitive with pre-existing Kalman-based methods for inverse problems.}, language = {en} } @article{NicolaiWittFrieseetal.2022, author = {Nicolai, Merle Marie and Witt, Barbara and Friese, Sharleen and Michaelis, Vivien and H{\"o}lz-Armstrong, Lisa and Martin, Maximilian and Ebert, Franziska and Schwerdtle, Tanja and Bornhorst, Julia}, title = {Mechanistic studies on the adverse effects of manganese overexposure in differentiated LUHMES cells}, series = {Food and chemical toxicology}, volume = {161}, journal = {Food and chemical toxicology}, publisher = {Elsevier}, address = {Oxford}, issn = {0278-6915}, doi = {10.1016/j.fct.2022.112822}, pages = {10}, year = {2022}, abstract = {Manganese (Mn) is an essential trace element, but overexposure is associated with toxicity and neurological dysfunction. Accumulation of Mn can be observed in dopamine-rich regions of the brain in vivo and Mn-induced oxidative stress has been discussed extensively. Nevertheless, Mn-induced DNA damage, adverse effects of DNA repair, and possible resulting consequences for the neurite network are not yet characterized. For this, LUHMES cells were used, as they differentiate into dopaminergic-like neurons and form extensive neurite networks. Experiments were conducted to analyze Mn bioavailability and cytotoxicity of MnCl2, indicating a dose-dependent uptake and substantial cytotoxic effects. DNA damage, analyzed by means of 8-oxo-7,8-dihydro-2'-guanine (8oxodG) and single DNA strand break formation, showed significant dose- and time-dependent increase of DNA damage upon 48 h Mn exposure. Furthermore, the DNA damage response was increased which was assessed by analytical quantification of poly(ADP-ribosyl)ation (PARylation). Gene expression of the respective DNA repair genes was not significantly affected. Degradation of the neuronal network is significantly altered by 48 h Mn exposure. Altogether, this study contributes to the characterization of Mn-induced neurotoxicity, by analyzing the adverse effects of Mn on genome integrity in dopaminergic-like neurons and respective outcomes.}, language = {en} } @article{SandhageHofmannAngombeKindermannetal.2022, author = {Sandhage-Hofmann, Alexandra and Angombe, Simon and Kindermann, Liana and Linst{\"a}dter, Anja and M{\"o}rchen, Ramona}, title = {Conservation with elephants and agricultural intensification}, series = {Geoderma : an international journal of soil science}, volume = {425}, journal = {Geoderma : an international journal of soil science}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0016-7061}, doi = {10.1016/j.geoderma.2022.116009}, pages = {15}, year = {2022}, abstract = {Nature conservation is currently shaping many terrestrial ecosystems in Africa. This is particularly evident in Sub-Saharan Africa (SSA), where conservation is intended to recover wildlife populations, with special focus on elephants. Rising numbers of elephants induce woody biomass losses but increase soil organic carbon (SOC) stocks from decaying wood and dung. We hypothesized that these increases under wildlife conservation in SSA go along with rising contents of plant residues in SOC, traceable by the molecular markers lignin and n-alkanes. In contrast, agricultural intensification would reduce them due to lower C input and faster SOC turnover through tillage. To test this, we analyzed lignin by the CuO oxidation method and n-alkanes by fast pressurized solvent extraction in topsoils (0-10 cm) of Arenosols and corresponding plant samples (trees, grasses and crops). Sampling sites followed conservation gradients with low, medium and high elephant densities and intensification gradients with rangeland and cropland in the woodland savanna of the Namibian Zambezi Region. Patterns of lignin-derived phenols were retained in the soil, whereas n-alkanes showed shifts in chain lengths. n-Alkanes also showed no clear increase or decrease under conservation or intensification, respectively. Differently, lignin-derived phenols showed lower values under intensification than under conservation. Confirming our hypothesis, rising SOC contents with rising elephant densities (from 4.4 at low to 5.7 g kg(-1) SOC at high elephant densities) went along with an increasing accumulation of lignin-derived phenols (24.4-34.8 g kg(-1) VSCOC). This increase is associated with the input of woody debris to the soil, as indicated by V-units and carbon isotopes, modulated by clay and woody biomass. We conclude, that increasing input of woody residues into soil by browsing behaviour of elephants is an important mechanism for controlling SOC supply in the context of wildlife conservation and is traceable with lignin-derived phenols, but not with n-alkanes.}, language = {en} } @article{ZhengToenjes2022, author = {Zheng, Chunming and T{\"o}njes, Ralf}, title = {Noise-induced swarming of active particles}, series = {Physical review : E, Statistical, nonlinear and soft matter physics}, volume = {106}, journal = {Physical review : E, Statistical, nonlinear and soft matter physics}, number = {6}, publisher = {American Physical Society}, address = {College Park}, issn = {2470-0045}, doi = {10.1103/PhysRevE.106.064601}, pages = {7}, year = {2022}, abstract = {We report on the effect of spatially correlated noise on the velocities of self-propelled particles. Correlations in the random forces acting on self-propelled particles can induce directed collective motion, i.e., swarming. Even with repulsive coupling in the velocity directions, which favors a disordered state, strong correlations in the fluctuations can align the velocities locally leading to a macroscopic, turbulent velocity field. On the other hand, while spatially correlated noise is aligning the velocities locally, the swarming transition to globally directed motion is inhibited when the correlation length of the noise is nonzero, but smaller than the system size. We analyze the swarming transition in d-dimensional space in a mean field model of globally coupled velocity vectors.}, language = {en} } @article{AbramovaGladkaya2024, author = {Abramova, Olga and Gladkaya, Margarita}, title = {Behind videoconferencing fatigue at work}, series = {Business \& information systems engineering}, journal = {Business \& information systems engineering}, publisher = {Springer Fachmedien}, address = {Wiesbaden}, issn = {2363-7005}, doi = {10.1007/s12599-024-00874-7}, pages = {19}, year = {2024}, abstract = {A remarkable peculiarity of videoconferencing (VC) applications - the self-view - a.k.a. digital mirror, is examined as a potential reason behind the voiced exhaustion among users. This work draws on technostress research and objective self-awareness theory and proposes the communication role (sender vs. receiver) as an interaction variable. We report the results of two studies among European employees (n1 = 176, n2 = 253) with a one-year time lag. A higher frequency of self-view in a VC when receiving a message, i.e., listening to others, indirectly increases negative affect (study 1 \& 2) and exhaustion (study 2) via the increased state of public self-awareness. Self-viewing in the role of message sender, e.g., as an online presenter, also increases public self-awareness, but its overall effects are less harmful. As for individual differences, users predisposed to public self-consciousness were more concerned with how other VC participants perceived them. Gender effects were insignificant.}, language = {en} } @misc{GenazzanoMompo2022, author = {Genazzano Mompo, Pablo Adrian}, title = {Elettra Stimilli 'Jacob Taubes: Soberan{\´i}a y tiempo mesi{\´a}nico'. [Trad. Martino Sacchi. Revisi{\´o}n de Francisco Caja y Volker Herrmann. Barcelona: Los Libros del T{\´a}bano, 2020, 360 p., ISBN: 9788409263097]}, series = {Convivium - Revista de Filosofia}, journal = {Convivium - Revista de Filosofia}, number = {35}, publisher = {Universitat de Barcelona}, address = {Barcelona}, issn = {0010-8235}, pages = {245 -- 249}, year = {2022}, language = {es} } @article{ZurellKoenigMalchowetal.2022, author = {Zurell, Damaris and K{\"o}nig, Christian and Malchow, Anne-Kathleen and Kapitza, Simon and Bocedi, Greta and Travis, Justin M. J. and Fandos, Guillermo}, title = {Spatially explicit models for decision-making in animal conservation and restoration}, series = {Ecography : pattern and diversity in ecology / Nordic Ecologic Society Oikos}, journal = {Ecography : pattern and diversity in ecology / Nordic Ecologic Society Oikos}, number = {4}, publisher = {Wiley-Blackwell}, address = {Oxford}, issn = {1600-0587}, doi = {10.1111/ecog.05787}, pages = {1 -- 16}, year = {2022}, abstract = {Models are useful tools for understanding and predicting ecological patterns and processes. Under ongoing climate and biodiversity change, they can greatly facilitate decision-making in conservation and restoration and help designing adequate management strategies for an uncertain future. Here, we review the use of spatially explicit models for decision support and to identify key gaps in current modelling in conservation and restoration. Of 650 reviewed publications, 217 publications had a clear management application and were included in our quantitative analyses. Overall, modelling studies were biased towards static models (79\%), towards the species and population level (80\%) and towards conservation (rather than restoration) applications (71\%). Correlative niche models were the most widely used model type. Dynamic models as well as the gene-to-individual level and the community-to-ecosystem level were underrepresented, and explicit cost optimisation approaches were only used in 10\% of the studies. We present a new model typology for selecting models for animal conservation and restoration, characterising model types according to organisational levels, biological processes of interest and desired management applications. This typology will help to more closely link models to management goals. Additionally, future efforts need to overcome important challenges related to data integration, model integration and decision-making. We conclude with five key recommendations, suggesting that wider usage of spatially explicit models for decision support can be achieved by 1) developing a toolbox with multiple, easier-to-use methods, 2) improving calibration and validation of dynamic modelling approaches and 3) developing best-practise guidelines for applying these models. Further, more robust decision-making can be achieved by 4) combining multiple modelling approaches to assess uncertainty, and 5) placing models at the core of adaptive management. These efforts must be accompanied by long-term funding for modelling and monitoring, and improved communication between research and practise to ensure optimal conservation and restoration outcomes.}, language = {en} } @article{WittStibollerRaschkeetal.2021, author = {Witt, Barbara and Stiboller, Michael and Raschke, Stefanie and Friese, Sharleen and Ebert, Franziska and Schwerdtle, Tanja}, title = {Characterizing effects of excess copper levels in a human astrocytic cell line with focus on oxidative stress markers}, series = {Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements, GMS}, volume = {65}, journal = {Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements, GMS}, publisher = {Elsevier}, address = {M{\"u}nchen}, issn = {1878-3252}, doi = {10.1016/j.jtemb.2021.126711}, pages = {9}, year = {2021}, abstract = {Background: Being an essential trace element, copper is involved in diverse physiological processes. However, excess levels might lead to adverse effects. Disrupted copper homeostasis, particularly in the brain, has been associated with human diseases including the neurodegenerative disorders Wilson and Alzheimer?s disease. In this context, astrocytes play an important role in the regulation of the copper homeostasis in the brain and likely in the prevention against neuronal toxicity, consequently pointing them out as a potential target for the neurotoxicity of copper. Major toxic mechanisms are discussed to be directed against mitochondria probably via oxidative stress. However, the toxic potential and mode of action of copper in astrocytes is poorly understood, so far. Methods: In this study, excess copper levels affecting human astrocytic cell model and their involvement in the neurotoxic mode of action of copper, as well as, effects on the homeostasis of other trace elements (Mn, Fe, Ca and Mg) were investigated. Results: Copper induced substantial cytotoxic effects in the human astrocytic cell line following 48 h incubation (EC30: 250 ?M) and affected mitochondrial function, as observed via reduction of mitochondrial membrane potential and increased ROS production, likely originating from mitochondria. Moreover, cellular GSH metabolism was altered as well. Interestingly, not only cellular copper levels were affected, but also the homeostasis of other elements (Ca, Fe and Mn) were disrupted. Conclusion: One potential toxic mode of action of copper seems to be effects on the mitochondria along with induction of oxidative stress in the human astrocytic cell model. Moreover, excess copper levels seem to interact with the homeostasis of other essential elements such as Ca, Fe and Mn. Disrupted element homeostasis might also contribute to the induction of oxidative stress, likely involved in the onset and progression of neurodegenerative disorders. These insights in the toxic mechanisms will help to develop ideas and approaches for therapeutic strategies against copper-mediated diseases.}, language = {en} } @article{PasechnikShmelevaSaidgazievetal.2022, author = {Pasechnik, Sergey V. and Shmeleva, Dina and Saidgaziev, Ayvr Sh. and Kharlamov, Semen and Vasilieva, Aleksandra A. and Santer, Svetlana}, title = {Shear flows induced by electro-osmotic pumps in optofluidic liquid crystal cell for modulation of visible light and THz irradiation}, series = {Liquid Crystals and their Application : Russian Journal}, volume = {22}, journal = {Liquid Crystals and their Application : Russian Journal}, number = {3}, publisher = {Nanomaterials Research Institute}, address = {Ivanovo}, issn = {1991-3966}, doi = {10.18083/LCAppl.2022.3.49}, pages = {49 -- 57}, year = {2022}, abstract = {The work is devoted to the use of electrokinetic phenomena in liquid crystals to create a new class of microfluidics devices - optofluidics, designed to control electromagnetic radiation, including the THz frequency range. To achieve the goal, an optical method is used to study changes in the orientational structure in LC layers caused by a shear flow generated by electroosmotic pumps. Simula-tion of LC behaviour in an experimental cell containing electroosmotic pumps and flat layers of a nematic liquid crystal is fulfilled. The experimental depend-ences of the intensity of polarized radiation passing through flat LC layers on the control voltage applied to the electroosmotic pump and the results of calcu-lations of the hydrodynamic and mechano-optical characteristics of the experi-mental LC cell are presented. The propagation of THz irradiation across the multilayer structure of the optofluidic cell is considered taking into account the minimum number of re-reflections of waves from different layers and the ab-sorption of THz irradiation in a propylene and a liquid crystal.}, language = {en} } @article{LueckGuillemoteauTronickeetal.2022, author = {L{\"u}ck, Erika and Guillemoteau, Julien and Tronicke, Jens and Rummel, Udo and Hierold, Wilfried}, title = {From point to field scale-indirect monitoring of soil moisture variations at the DWD test site in Falkenberg}, series = {Geoderma : an international journal of soil science}, volume = {427}, journal = {Geoderma : an international journal of soil science}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0016-7061}, doi = {10.1016/j.geoderma.2022.116134}, pages = {15}, year = {2022}, abstract = {Information regarding the spatial distribution of soil water content is key in many disciplines and applications including soil and atmospheric sciences, hydrology, and agricultural engineering. Thus, within the past decades various experimental methods and strategies have been developed to map spatial variations in soil moisture distribution and to monitor temporal changes. Our study examines the combination of electrical resistivity mapping and point observations of soil moisture to infer the spatial and the temporal variability of soil moisture. Over a period of around two years, we performed field measurements on six days to collect repeated electrical resistivity mapping data for a nine-hectare test site south-east of Berlin, Germany. Permanently installed TDR probes, temporary TDR measurements within permanently installed tubes, and gravimetric measurements using soil samples provided soil moisture data at various selected points. In addition, soil analysis and classification results are available for 132 regularly distributed positions up to depths of 1.2 m. We compare and link three-dimensional resistivity models obtained via data inversion to soil composition and soil moisture as provided by our point data. Both the soil samples and the resistivity models indicate a two-layer medium characterized by a sandy top layer with varying thickness and a loamy bottom soil. For all six field campaigns, we observe similar resistivity patterns reflecting the temporally stable influence of soil texture. While the overall patterns are stable, the range of resistivity values changes with soil moisture. Finally, to estimate spatial models of soil moisture, we link our soil moisture and resistivity data using empirical petrophysical models relying on a second order polynomial function. We observe a mean prediction error for soil moisture of +/-0.034 m3 \& BULL; m? 3 using all observation points while we notice that point-specific models further reduce the error. Thus, we conclude that our experimental and data analysis strategies represent a reliable approach to establish site-specific models and to estimate three-dimensional moisture distribution including temporal variations.}, language = {en} } @inproceedings{SchulzeDoeschnerGoegeretal.2022, author = {Schulze, Kora and D{\"o}schner, Larissa and G{\"o}ger, Lea and Franz, K. and M{\"u}ller-Werdan, Ursula and Norman, Kristina and Herpich, Catrin}, title = {Kurzeitige vegane Intervention senkt Inflammationsmarker}, series = {Zeitschrift f{\"u}r Gerontologie und Geriatrie}, volume = {55}, booktitle = {Zeitschrift f{\"u}r Gerontologie und Geriatrie}, number = {Suppl. 1}, publisher = {Springer Medizin}, address = {Heidelberg}, issn = {0948-6704}, doi = {10.1007/s00391-022-02095-7}, pages = {S83 -- S84}, year = {2022}, language = {de} } @article{SteinMukkavilliWagener2022, author = {Stein, Lina and Mukkavilli, Surya Karthik and Wagener, Thorsten}, title = {Lifelines for a drowning science - improving findability and synthesis of hydrologic publications}, series = {Hydrological processes}, volume = {36}, journal = {Hydrological processes}, number = {11}, publisher = {Wiley}, address = {New York, NY}, issn = {0885-6087}, doi = {10.1002/hyp.14742}, pages = {7}, year = {2022}, abstract = {Increasing publication numbers make it difficult to keep up with knowledge evolution in a science like hydrology. Here we give recommendations to authors and journals for writing future-proof articles that contribute to knowledge accumulation and synthesis.}, language = {en} } @article{RuszkiewiczPapatheodorouJaecketal.2023, author = {Ruszkiewicz, Joanna and Papatheodorou, Ylea and J{\"a}ck, Nathalie and Melzig, Jasmin and Eble, Franziska and Pirker, Annika and Thomann, Marius and Haberer, Andreas and Rothmiller, Simone and B{\"u}rkle, Alexander and Mangerich, Aswin}, title = {NAD+ Acts as a protective factor in cellular stress response to DNA alkylating agents}, series = {Cells : open access journal}, volume = {12}, journal = {Cells : open access journal}, number = {19}, publisher = {MDPI}, address = {Basel}, issn = {2073-4409}, doi = {10.3390/cells12192396}, pages = {22}, year = {2023}, abstract = {Sulfur mustard (SM) and its derivatives are potent genotoxic agents, which have been shown to trigger the activation of poly (ADP-ribose) polymerases (PARPs) and the depletion of their substrate, nicotinamide adenine dinucleotide (NAD+). NAD+ is an essential molecule involved in numerous cellular pathways, including genome integrity and DNA repair, and thus, NAD+ supplementation might be beneficial for mitigating mustard-induced (geno)toxicity. In this study, the role of NAD+ depletion and elevation in the genotoxic stress response to SM derivatives, i.e., the monofunctional agent 2-chloroethyl-ethyl sulfide (CEES) and the crosslinking agent mechlorethamine (HN2), was investigated with the use of NAD+ booster nicotinamide riboside (NR) and NAD+ synthesis inhibitor FK866. The effects were analyzed in immortalized human keratinocytes (HaCaT) or monocyte-like cell line THP-1. In HaCaT cells, NR supplementation, increased NAD+ levels, and elevated PAR response, however, did not affect ATP levels or DNA damage repair, nor did it attenuate long- and short-term cytotoxicities. On the other hand, the depletion of cellular NAD+ via FK866 sensitized HaCaT cells to genotoxic stress, particularly CEES exposure, whereas NR supplementation, by increasing cellular NAD+ levels, rescued the sensitizing FK866 effect. Intriguingly, in THP-1 cells, the NR-induced elevation of cellular NAD+ levels did attenuate toxicity of the mustard compounds, especially upon CEES exposure. Together, our results reveal that NAD+ is an important molecule in the pathomechanism of SM derivatives, exhibiting compound-specificity. Moreover, the cell line-dependent protective effects of NR are indicative of system-specificity of the application of this NAD+ booster.}, language = {en} } @article{SaguTchewonpiRawelRohn2022, author = {Sagu Tchewonpi, Sorel and Rawel, Harshadrai M. and Rohn, Sascha}, title = {Targeted bottom-up mass spectrometry approach for the relative quantification of post-translational modification of bovine κ-casein during milk fermentation}, series = {Molecules}, volume = {27}, journal = {Molecules}, number = {18}, publisher = {MDPI}, address = {Basel}, issn = {1420-3049}, doi = {10.3390/molecules27185834}, pages = {17}, year = {2022}, abstract = {kappa-casein (kappa-CN) is one of the key components in bovine milk, playing a unique role in the structuration of casein micelles. It contains in its chemical structure up to sixteen amino acid residues (mainly serine and threonine) susceptible to modifications, including glycosylation and phosphorylation, which may further be formed during milk processing. In this study, changes in post-translational modification (PTM) of kappa-CN during bovine milk fermentation were investigated. One-to-five-day fermented milk samples were produced. A traditional bottom-up proteomics approach was used to establish a multiple-reaction monitoring (MRM) method for relative quantification of kappa-CN PTM. Endoproteinase Glu-C was found to efficiently digest the kappa-CN molecule. The developed LC-MS method was validated by performing assessments of linearity, precision, repeatability, reproducibility, limit of detection (LOD), and limit of quantification (LOQ). Among the yielded peptides, four of them containing serine and threonine residues were identified and the unmodified as well as the modified variants of each of them were relatively quantified. These peptides were (1) IPTINTIASGEPTSTTE ([140, 158]), (2) STVATLE ([162, 168]), (3) DSPE ([169, 172]), and (4) INTVQVTSTAV ([180, 190]). Distribution analysis between unmodified and modified peptides revealed that over 50\% of kappa-CN was found in one of its modified forms in milk. The fermentation process further significantly altered the composition between unmodified/modified kappa-CN, with glycoslaytion being predominant compared to phosphorylation (p < 0.01). Further method development towards alpha and beta-CN fractions and their PTM behavior would be an asset to better understand the changes undergone by milk proteins and the micellar structure during fermentation.}, language = {en} } @article{ShlapunovTarchanov2022, author = {Shlapunov, Alexander A. and Tarchanov, Nikolaj Nikolaevič}, title = {Inverse image of precompact sets and regular solutions to the Navier-Stokes equations}, series = {Vestnik Udmurtskogo Universiteta. Matematika, mechanika, kompʹjuternye nauki}, volume = {32}, journal = {Vestnik Udmurtskogo Universiteta. Matematika, mechanika, kompʹjuternye nauki}, number = {2}, publisher = {Udmurtskij gosudarstvennyj universitet}, address = {Iževsk}, issn = {1994-9197}, doi = {10.35634/vm220208}, pages = {278 -- 297}, year = {2022}, abstract = {We consider the initial value problem for the Navier-Stokes equations over R-3 x [0, T] with time T > 0 in the spatially periodic setting. We prove that it induces open injective mappings A(s): B-1(s) -> B-2(s-1) where B-1(s), B-2(s-1) are elements from scales of specially constructed function spaces of Bochner-Sobolev typeparametrized with the smoothness index s is an element of N. Finally, we prove that a map Asis surjective if and only if the inverse image A(s)(- 1) (K) of any pre compact set K from the range of the map Asis bounded in the Bochner space L-s([0, T], L-r(T-3))with the Ladyzhenskaya-Prodi-Serrin numbers s, r.}, language = {en} } @article{LachmairFischerGerjets2022, author = {Lachmair, Martin and Fischer, Martin H. and Gerjets, Peter}, title = {Action-control mappings of interfaces in virtual reality: a study of embodied interaction}, series = {Frontiers in virtual reality}, volume = {3}, journal = {Frontiers in virtual reality}, publisher = {Frontiers Media}, address = {Lausanne}, issn = {2673-4192}, doi = {10.3389/frvir.2022.976849}, pages = {11}, year = {2022}, abstract = {The development of interface technologies is driven by the goal of making interaction more positive through natural action-control mappings. In Virtual Reality (VR), the entire body is potentially involved for interaction, using such mappings with a maximum of degrees of freedom. The downside is the increase in interaction complexity, which can dramatically influence interface design. A cognitive perspective on detailed aspects of interaction patterns is lacking in common interface design guidelines, although it can be helpful to make this complexity controllable and, thus, make interaction behavior predictable. In the present study, the distinction between grounding, embodiment, and situatedness (the GES framework) is applied to organize aspects of interactions and to compare them with each other. In two experiments, zooming into or out of emotional pictures through changes of arm span was examined in VR. There are qualitatively different aspects during such an interaction: i) perceptual aspects caused by zooming are fundamental for human behavior (Grounding: closer objects appear bigger) and ii) aspects of gestures correspond to the physical characteristics of the agents (Embodiment: little distance of hands signals little or, in contrast, "creating more detail"). The GES-framework sets aspects of Grounding against aspects of Embodiment, thus allowing to predict human behavior regarding these qualitatively different aspects. For the zooming procedure, the study shows that Grounding can overrule Embodiment in interaction design. Thus, we propose GES as a cognitive framework that can help to inform interaction guidelines for user interface design in VR.}, language = {en} } @misc{HorvatWienerSchmelingetal.2022, author = {Horvat, Anja Kranjc and Wiener, Jeff and Schmeling, Sascha Marc and Borowski, Andreas}, title = {What does the curriculum say? Review of the particle physics content in 27 high-school physics curricula}, series = {Physics}, volume = {4}, journal = {Physics}, number = {4}, publisher = {MDPI}, address = {Basel}, issn = {2624-8174}, doi = {10.3390/physics4040082}, pages = {1278 -- 1298}, year = {2022}, abstract = {This international curricular review provides a structured overview of the particle physics content in 27 state, national, and international high-school physics curricula. The review was based on a coding manual that included 60 concepts that were identified as relevant for high-school particle physics education. Two types of curricula were reviewed, namely curricula with a dedicated particle physics chapter and curricula without a dedicated particle physics chapter. The results of the curricular review show that particle physics concepts are explicitly or implicitly present in all reviewed curricula. However, the number of particle physics concepts that are featured in a curriculum varies greatly across the reviewed curricula. We identified core particle physics concepts that can be found in most curricula. Here, elementary particles, fundamental interactions, and charges were identified as explicit particle physics concepts that are featured in more than half of the reviewed curricula either as content or context. Indeed, theoretical particle physics concepts are more prominent in high-school physics curricula than experimental particle physics concepts. Overall, this international curricular review provides the basis for future curricular development with respect to particle physics and suggests an increased inclusion of experimental particle physics concepts in high-school physics curricula.}, language = {en} } @article{LunaKorup2022, author = {Luna, Lisa and Korup, Oliver}, title = {Seasonal landslide activity lags annual precipitation pattern in the Pacific Northwest}, series = {Geophysical research letters}, volume = {49}, journal = {Geophysical research letters}, number = {18}, publisher = {Wiley}, address = {Hoboken, NJ}, issn = {0094-8276}, doi = {10.1029/2022GL098506}, pages = {11}, year = {2022}, abstract = {Seasonal variations in landslide activity remain understudied compared to recent advances in landslide early warning at hourly to daily timescales. Here, we learn the seasonal pattern of monthly landslide activity in the Pacific Northwest from five heterogeneous landslide inventories with differing spatial and temporal coverage and reporting protocols combined in a Bayesian multi-level model. We find that landslide activity is distinctly seasonal, with credible increases in landslide intensity, inter-annual variability, and probability marking the onset of the landslide season in November. Peaks in landslide probability in January and intensity in February lag the annual peak in mean monthly precipitation and landslide activity is more variable in winter than in summer, when landslides are rare. For a given monthly rainfall, landslide intensity at the season peak in February is up to 10 times higher than at the onset in November, underlining the importance of antecedent seasonal hillslope conditions.}, language = {en} }