@phdthesis{Prevot2006,
  author    = {Prevot, Michelle Elizabeth},
  title     = {Introduction of a thermo-sensitive non-polar species into polyelectrolyte multilayer capsules for drug delivery},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-7785},
  school      = {Universit{\"a}t Potsdam},
  year      = {2006},
  abstract  = {The layer-by-layer assembly (LBL) of polyelectrolytes has been extensively studied for the preparation of ultrathin films due to the versatility of the build-up process. The control of the permeability of these layers is particularly important as there are potential drug delivery applications. Multilayered polyelectrolyte microcapsules are also of great interest due to their possible use as microcontainers. This work will present two methods that can be used as employable drug delivery systems, both of which can encapsulate an active molecule and tune the release properties of the active species. Poly-(N-isopropyl acrylamide), (PNIPAM) is known to be a thermo-sensitive polymer that has a Lower Critical Solution Temperature (LCST) around 32oC; above this temperature PNIPAM is insoluble in water and collapses. It is also known that with the addition of salt, the LCST decreases. This work shows Differential Scanning Calorimetry (DSC) and Confocal Laser Scanning Microscopy (CLSM) evidence that the LCST of the PNIPAM can be tuned with salt type and concentration. Microcapsules were used to encapsulate this thermo-sensitive polymer, resulting in a reversible and tunable stimuli- responsive system. The encapsulation of the PNIPAM inside of the capsule was proven with Raman spectroscopy, DSC (bulk LCST measurements), AFM (thickness change), SEM (morphology change) and CLSM (in situ LCST measurement inside of the capsules). The exploitation of the capsules as a microcontainer is advantageous not only because of the protection the capsules give to the active molecules, but also because it facilitates easier transport. The second system investigated demonstrates the ability to reduce the permeability of polyelectrolyte multilayer films by the addition of charged wax particles. The incorporation of this hydrophobic coating leads to a reduced water sensitivity particularly after heating, which melts the wax, forming a barrier layer. This conclusion was proven with Neutron Reflectivity by showing the decreased presence of D2O in planar polyelectrolyte films after annealing creating a barrier layer. The permeability of capsules could also be decreased by the addition of a wax layer. This was proved by the increase in recovery time measured by Florescence Recovery After Photobleaching, (FRAP) measurements. In general two advanced methods, potentially suitable for drug delivery systems, have been proposed. In both cases, if biocompatible elements are used to fabricate the capsule wall, these systems provide a stable method of encapsulating active molecules. Stable encapsulation coupled with the ability to tune the wall thickness gives the ability to control the release profile of the molecule of interest.},
  subject      = {Mikrokapsel},
  language  = {en}
}
@phdthesis{Schauer2006,
  author    = {Schauer, Nicolas},
  title     = {Quantitative trait loci (QTL) for metabolite accumulation and metabolic regulation : metabolite profiling of interspecific crosses of tomato},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-7643},
  school      = {Universit{\"a}t Potsdam},
  year      = {2006},
  abstract  = {The advent of large-scale and high-throughput technologies has recently caused a shift in focus in contemporary biology from decades of reductionism towards a more systemic view. Alongside the availability of genome sequences the exploration of organisms utilizing such approach should give rise to a more comprehensive understanding of complex systems. Domestication and intensive breeding of crop plants has led to a parallel narrowing of their genetic basis. The potential to improve crops by conventional breeding using elite cultivars is therefore rather limited and molecular technologies, such as marker assisted selection (MAS) are currently being exploited to re-introduce allelic variance from wild species. Molecular breeding strategies have mostly focused on the introduction of yield or resistance related traits to date. However given that medical research has highlighted the importance of crop compositional quality in the human diet this research field is rapidly becoming more important. Chemical composition of biological tissues can be efficiently assessed by metabolite profiling techniques, which allow the multivariate detection of metabolites of a given biological sample. Here, a GC/MS metabolite profiling approach has been applied to investigate natural variation of tomatoes with respect to the chemical composition of their fruits. The establishment of a mass spectral and retention index (MSRI) library was a prerequisite for this work in order to establish a framework for the identification of metabolites from a complex mixture. As mass spectral and retention index information is highly important for the metabolomics community this library was made publicly available. Metabolite profiling of tomato wild species revealed large differences in the chemical composition, especially of amino and organic acids, as well as on the sugar composition and secondary metabolites. Intriguingly, the analysis of a set of S. pennellii introgression lines (IL) identified 889 quantitative trait loci of compositional quality and 326 yield-associated traits. These traits are characterized by increases/decreases not only of single metabolites but also of entire metabolic pathways, thus highlighting the potential of this approach in uncovering novel aspects of metabolic regulation. Finally the biosynthetic pathway of the phenylalanine-derived fruit volatiles phenylethanol and phenylacetaldehyde was elucidated via a combination of metabolic profiling of natural variation, stable isotope tracer experiments and reverse genetic experimentation.},
  subject      = {Tomate},
  language  = {en}
}
@misc{Trautner1997,
  author    = {Trautner, Bernhard J.},
  title     = {Hegemonialm{\"a}chte im Vorderen und Mittleren Orient : die Dritte Partei in internationalen Konflikten},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-7998},
  year      = {1997},
  abstract  = {During the last five decades hegemons played an important role in de-escalating international conflicts in the subregion defined as the core of Oriens Islamicus. Statistical analysis of large datasets shows that half of all conflicts remained without any interference from the hegemonial powers at all - both on global scale and in the subregion. In all other cases however, hegemons (especially super-powers in the role of patrons) tended more often to act as (power-) mediators when their client-state was engaged in conflict with a client of the opposing superpower in Oriens Islamicus than they did on global scale. They did this in their own interest in order to avoid direct involvement, i.e. possible danger of a nuclear escalation. In contrast to conventional mediation theory they were more effective in conflict de-escalation than other mediators, especially in conflicts between Israel and its Arab neighbours. The end of bipolarity in the international system also brought this mechanism of de-escalation to an end. It leaves the hegemon(s) as a potentially powerful third party on the one hand, but on the other their inclination to become involved in regional conflict remains rather diminished as long as the basic national interests in the area are not at stake.},
  language  = {de}
}
@misc{Hellmann2004,
  author    = {Hellmann, Gunther},
  title     = {Wider die machtpolitische Resozialisierung der deutschen Außenpolitik},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-8027},
  year      = {2004},
  abstract  = {German foreign policy is in the midst of a far-reaching transformation. Contrary to disciplinary expectations, this process is neither properly captured by descriptions in the liberal tradition („Europeanisation", „Civilian Power") nor by Realist expectations that Germany is doomed to „remilitarise" and/or „renationalise". However, the key term of foreign policy discourse, „normalisation", is an unmistakable code, signalling a rediscovery of traditional Realpolitik practices which fit Germany's current environment. The paper argues that rather than merely playing the role of an obedient disciple of Realpolitik socialisers, Germany ought to rehabilitate the foreign policy tradition of the Bonn Republic in support of an active Idealpolitik transformation of its environment. The article serves as a starting point for a debate on German foreign policy in the upcoming issues of WeltTrends.},
  language  = {de}
}
@inproceedings{Bischof2005,
  author    = {Bischof, Ulrike},
  title     = {Nachlasserschließung im Goethe- und Schiller-Archiv},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-6081},
  year      = {2005},
  abstract  = {Beitr{\"a}ge zum Thema "Nachl{\"a}sse an Universit{\"a}ts- und Hochschularchiven sowie Archiven wissenschaftlicher Institutionen" im Rahmen der Fr{\"u}hjahrstagung der Fachgruppe 8: "Archivare an Hochschularchiven und Archiven wissenschaftlicher Institutionen" am 16./17. Juni an der Universit{\"a}t Potsdam.},
  subject      = {Archiv},
  language  = {de}
}
@inproceedings{Wiemers2005,
  author    = {Wiemers, Gerald},
  title     = {Der Nachlass des Erziehungswissenschaftlers und Philosophen Theodor Litt in seiner {\"o}ffentlichen Wirkung},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-6113},
  year      = {2005},
  abstract  = {Beitr{\"a}ge zum Thema "Nachl{\"a}sse an Universit{\"a}ts- und Hochschularchiven sowie Archiven wissenschaftlicher Institutionen" im Rahmen der Fr{\"u}hjahrstagung der Fachgruppe 8: "Archivare an Hochschularchiven und Archiven wissenschaftlicher Institutionen" am 16./17. Juni an der Universit{\"a}t Potsdam.},
  subject      = {Archiv},
  language  = {de}
}
@inproceedings{Schultze2005,
  author    = {Schultze, Winfried},
  title     = {Zufall - Wunsch - Planung : die Erwerbung von Nachl{\"a}ssen zur Bestandserg{\"a}nzung},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-6098},
  year      = {2005},
  abstract  = {Nachl{\"a}sse sind pers{\"o}nliches Eigentum und unterliegen deshalb keiner Abgabepflicht. Der Wunsch des Nachlassers bez{\"u}glich der weiteren Aufbewahrung seines schriftlichen Erbes ist demzufolge prim{\"a}r gegen{\"u}ber allen unseren W{\"u}nschen. Wir k{\"o}nnen nicht fordern, sondern nur bitten, uns durch eigene Leistungen anbieten und die zuk{\"u}nftigen Nachlassenden oder deren Erben {\"u}berzeugen. Die nicht vorhandene institutionelle Zust{\"a}ndigkeit f{\"u}r die {\"U}bernahme von Nachl{\"a}ssen erzeugt die Reibungspunkte zwischen den Einrichtungen, die sich um den Erwerb von Nachl{\"a}ssen bem{\"u}hen: Archive - Bibliotheken - Museen - Sammlungen. Die W{\"u}nsche zum Erwerb des Nachlasses einer bestimmten Person - egal ob Wissenschaftler, K{\"u}nstler oder Politiker - sind demzufolge immer an verschiedenen Orten gleichzeitig vorhanden. Der Zufall entscheidet dann leider meist dar{\"u}ber, an welcher Stelle der Nachlass zuk{\"u}nftig verwahrt und wissenschaftlich genutzt wird. Es stellt sich die Frage, ob wir auf solche Zuf{\"a}lle hoffen und warten sollen, oder ob wir nicht eher eine engagierte - gemeinsam zwischen den Archiven abgestimmte - Erwerbspolitik betrieben sollten. ------------ Beitr{\"a}ge zum Thema "Nachl{\"a}sse an Universit{\"a}ts- und Hochschularchiven sowie Archiven wissenschaftlicher Institutionen" im Rahmen der Fr{\"u}hjahrstagung der Fachgruppe 8: "Archivare an Hochschularchiven und Archiven wissenschaftlicher Institutionen" am 16./17. Juni an der Universit{\"a}t Potsdam.},
  subject      = {Archiv},
  language  = {de}
}
@unpublished{RoellyFradon2006,
  author    = {Roelly, Sylvie and Fradon, Myriam},
  title     = {Infinite system of Brownian balls : equilibrium measures are canonical Gibbs},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-6720},
  year      = {2006},
  abstract  = {We consider a system of infinitely many hard balls in R<sup>d undergoing Brownian motions and submitted to a smooth pair potential. It is modelized by an infinite-dimensional stochastic differential equation with a local time term. We prove that the set of all equilibrium measures, solution of a detailed balance equation, coincides with the set of canonical Gibbs measures associated to the hard core potential added to the smooth interaction potential.},
  language  = {en}
}
@phdthesis{Unterstab2005,
  author    = {Unterstab, Gunhild},
  title     = {Charakterisierung der viralen Genprodukte p10 und P des Borna Disease Virus},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-6905},
  school      = {Universit{\"a}t Potsdam},
  year      = {2005},
  abstract  = {Das Borna Disease Virus (BDV, Bornavirus) besitzt ein einzelstr{\"a}ngiges RNA-Genom negativer Polarit{\"a}t und ist innerhalb der Ordnung Mononegavirales der Prototyp einer eigenen Virusfamilie, die der Bornaviridae. Eine außergew{\"o}hnliche Eigenschaft des Virus ist seine nukle{\"a}re Transkription und Replikation, eine weitere besteht in seiner F{\"a}higkeit, als neurotropes Virus sowohl in vivo als auch in vitro persistente Infektionen zu etablieren. Die zugrunde liegenden Mechanismen sowohl der Replikation als auch der Persistenz sind derzeit noch unzureichend verstanden, auch deshalb, weil das Virus noch relativ „jung" ist: Erste komplette Sequenzen des RNA-Genoms wurden 1994 publiziert und erst vor einigen Monaten gelang die Generierung rekombinanter Viren auf der Basis klonierter cDNA. Im Mittelpunkt dieser Arbeit standen das p10 Protein und das Phosphoprotein (P), die von der gemeinsamen Transkriptionseinheit II in {\"u}berlappenden Leserahmen kodiert werden. Als im Kern der Wirtszelle replizierendes Virus ist das Bornavirus auf zellul{\"a}re Importmechanismen angewiesen, um den Kernimport aller an der Replikation beteiligten viralen Proteine zu gew{\"a}hrleisten. Das p10 Protein ist ein negativer Regulator der viralen RNA-abh{\"a}ngigen RNA-Polymerase (L). In vitro Importexperimente zeigten, dass p10 {\"u}ber den klassischen Importin alpha/beta abh{\"a}ngigen Kernimportweg in den Nukleus transportiert wird. Dies war unerwartet, da p10 kein vorhersagbares klassisches Kernlokalisierungssignal (NLS) besitzt und weist darauf hin, dass der zellul{\"a}re Importapparat offensichtlich flexibler ist als allgemein angenommen. Die ersten 20 N-terminalen AS vermitteln sowohl Kernimport als auch die Bindung an den Importrezeptor Importin alpha. Durch Di-Alanin-Austauschmutagenese wurden die f{\"u}r diesen Transportprozess essentiellen AS identifiziert und die Bedeutung hydrophober und polarer AS-Reste demonstriert. Die F{\"a}higkeit des Bornavirus, persistente Infektionen zu etablieren, wirft die Frage auf, wie das Virus die zellul{\"a}ren antiviralen Abwehrmechanismen, insbesondere das Typ I Interferon (IFN)-System, unterwandert. Das virale P Protein wurde in dieser Arbeit als potenter Antagonist der IFN-Induktion charakterisiert. Es verhindert die Phosphorylierung des zentralen Transkriptionsfaktors IRF3 durch die zellul{\"a}re Kinase TBK1 und somit dessen Aktivierung. Der Befund, dass P mit TBK1 Komplexe bildet und zudem auch als Substrat f{\"u}r die zellul{\"a}re Kinase fungiert, erlaubt es, erstmalig einen Mechanismus zu postulieren, in dem ein virales Protein (BDV-P) als putatives TBK1-Pseudosubstrat die IRF3-Aktivierung kompetitiv hemmt.},
  subject      = {Interferon <beta->},
  language  = {de}
}
@book{OPUS4-721,
  title     = {Interdisciplinary studies on information structure : ISIS ; working papers of the SFB 632. - Vol. 1},
  editor    = {Ishihara, Shinichiro and Schmitz, Michaela and Schwarz, Anne},
  issn      = {1866-4725},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-8237},
  publisher      = {Universit{\"a}t Potsdam},
  year      = {2004},
  abstract  = {Contents: A1: Phonology and syntax of focussing and topicalisation: Gisbert Fanselow: Cyclic Phonology-Syntax-Interaction: Movement to First Position in German Caroline F{\´e}ry and Laura Herbst: German Sentence Accent Revisited Shinichiro Ishihara: Prosody by Phase: Evidence from Focus Intonation-Wh-scope Correspondence in Japanese A2: Quantification and information structure: Cornelia Endriss and Stefan Hinterwimmer: The Influence of Tense in Adverbial Quantification A3: Rhetorical Structure in Spoken Language: Modeling of Global Prosodic Parameters: Ekaterina Jasinskaja, J{\"o}rg Mayer and David Schlangen: Discourse Structure and Information Structure: Interfaces and Prosodic Realization B2: Focussing in African Tchadic languages: Katharina Hartmann and Malte Zimmermann: Focus Strategies in Chadic: The Case of Tangale Revisited D1: Linguistic database for information structure: Annotation and retrieval: Stefanie Dipper, Michael G{\"o}tze, Manfred Stede and Tillmann Wegst: ANNIS: A Linguistic Database for Exploring Information Structure},
  language  = {en}
}