@phdthesis{Wenk2020, author = {Wenk, Sebastian}, title = {Engineering formatotrophic growth in Escherichia coli}, school = {Universit{\"a}t Potsdam}, pages = {V, 107}, year = {2020}, abstract = {To meet the demands of a growing world population while reducing carbon dioxide (CO2) emissions, it is necessary to capture CO2 and convert it into value-added compounds. In recent years, metabolic engineering of microbes has gained strong momentum as a strategy for the production of valuable chemicals. As common microbial feedstocks like glucose directly compete with human consumption, the one carbon (C1) compound formate was suggested as an alternative feedstock. Formate can be easily produced by various means including electrochemical reduction of CO2 and could serve as a feedstock for microbial production, hence presenting a novel entry point for CO2 to the biosphere and a storage option for excess electricity. Compared to the gaseous molecule CO2, formate is a highly soluble compound that can be easily handled and stored. It can serve as a carbon and energy source for natural formatotrophs, but these microbes are difficult to cultivate and engineer. In this work, I present the results of several projects that aim to establish efficient formatotrophic growth of E. coli - which cannot naturally grow on formate - via synthetic formate assimilation pathways. In the first study, I establish a workflow for growth-coupled metabolic engineering of E. coli. I demonstrate this approach by presenting an engineering scheme for the PFL-threonine cycle, a synthetic pathway for anaerobic formate assimilation in E. coli. The described methods are intended to create a standardized toolbox for engineers that aim to establish novel metabolic routes in E. coli and related organisms. The second chapter presents a study on the catalytic efficiency of C1-oxidizing enzymes in vivo. As formatotrophic growth requires generation of both energy and biomass from formate, the engineered E. coli strains need to be equipped with a highly efficient formate dehydrogenase, which provides reduction equivalents and ATP for formate assimilation. I engineered a strain that cannot generate reducing power and energy for cellular growth, when fed on acetate. Under this condition, the strain depends on the introduction of an enzymatic system for NADH regeneration, which could further produce ATP via oxidative phosphorylation. I show that the strain presents a valuable testing platform for C1-oxidizing enzymes by testing different NAD-dependent formate and methanol dehydrogenases in the energy auxotroph strain. Using this platform, several candidate enzymes with high in vivo activity, were identified and characterized as potential energy-generating systems for synthetic formatotrophic or methylotrophic growth in E. coli.   In the third chapter, I present the establishment of the serine threonine cycle (STC) - a synthetic formate assimilation pathway - in E. coli. In this pathway, formate is assimilated via formate tetrahydrofolate ligase (FtfL) from Methylobacterium extorquens (M. extorquens). The carbon from formate is attached to glycine to produce serine, which is converted into pyruvate entering central metabolism. Via the natural threonine synthesis and cleavage route, glycine is regenerated and acetyl-CoA is produced as the pathway product. I engineered several selection strains that depend on different STC modules for growth and determined key enzymes that enable high flux through threonine synthesis and cleavage. I could show that expression of an auxiliary formate dehydrogenase was required to achieve growth via threonine synthesis and cleavage on pyruvate. By overexpressing most of the pathway enzymes from the genome, and applying adaptive laboratory evolution, growth on glycine and formate was achieved, indicating the activity of the complete cycle. The fourth chapter shows the establishment of the reductive glycine pathway (rGP) - a short, linear formate assimilation route - in E. coli. As in the STC, formate is assimilated via M. extorquens FtfL. The C1 from formate is condensed with CO2 via the reverse reaction of the glycine cleavage system to produce glycine. Another carbon from formate is attached to glycine to form serine, which is assimilated into central metabolism via pyruvate. The engineered E. coli strain, expressing most of the pathway genes from the genome, can grow via the rGP with formate or methanol as a sole carbon and energy source.}, language = {en} } @phdthesis{Schimpf2020, author = {Schimpf, Stefan}, title = {Herkunft und Ablagerungsmilieu quart{\"a}rer Sedimente im Einzugsgebiet des Heihe, NW China}, school = {Universit{\"a}t Potsdam}, pages = {xi, 186}, year = {2020}, abstract = {Der zentralasiatische Naturraum, wie er sich uns heute pr{\"a}sentiert, ist das Ergebnis eines Zusammenwirkens vieler verschiedener Faktoren {\"u}ber Jahrmillionen hinweg. Im aktuellen Kontext des Klimawandels zeigt sich jedoch, wie stark sich Stofffl{\"u}sse auch kurzfristig {\"a}ndern und dabei das Gesicht der Landschaft verwandeln k{\"o}nnen. Die Gobi-W{\"u}ste in der Inneren Mongolei (China), als Teil der gleichnamigen Trockenregionen Nordwestchinas, ist aufgrund der Ausgestaltung ihrer landschaftspr{\"a}genden Elemente sowie ihrer Landschaftsdynamik, im Zusammenhang mit der Lage zum Tibet-Plateau, in den Fokus der klimageschichtlichen Grundlagenforschung ger{\"u}ckt. Als großes Langzeitarchiv unterschiedlichster fluvialer, lakustriner und {\"a}olischer Sedimente stellt sie eine bedeutende Lokalit{\"a}t zur Rekonstruktion von lokalen und regionalen Stofffl{\"u}ssen dar.. Andererseits ist die Gobi-W{\"u}ste zugleich auch eine bedeutende Quelle f{\"u}r den {\"u}berregionalen Staubtransport, da sie aufgrund der klimatischen Bedingungen insbesondere der Erosion durch Ausblasung preisgegeben wird. Vor diesem Hintergrund erfolgten zwischen 2011 und 2014, im Rahmen des BMBF-Verbundprogramms WTZ Zentralasien - Monsundynamik \& Geo{\"o}kosysteme (F{\"o}rderkennzeichen 03G0814), mehrere deutsch-chinesische Expeditionen in das Ejina-Becken (Innere Mongolei) und das Qilian Shan-Vorland. Im Zuge dieser Expeditionen wurden f{\"u}r eine Bestimmung potenzieller Sedimentquellen erstmals zahlreiche Oberfl{\"a}chenproben aus dem gesamten Einzugsgebiet des Heihe (schwarzer Fluss) gesammelt. Zudem wurden mit zwei Bohrungen im inneren des Ejina-Beckens, erg{\"a}nzende Sedimentbohrkerne zum bestehenden Bohrkern D100 (siehe W{\"u}nnemann (2005)) abgeteuft, um weit reichende, erg{\"a}nzende Informationen zur Landschaftsgeschichte und zum {\"u}berregionalen Sedimenttransfer zu erhalten. Gegenstand und Ziel der vorliegenden Doktorarbeit ist die sedimentologisch-mineralogische Charakterisierung des Untersuchungsgebietes in Bezug auf potenzielle Sedimentquellen und Stofffl{\"u}sse des Ejina-Beckens sowie die Rekonstruktion der Ablagerungsgeschichte eines dort erbohrten, 19m langen Sedimentbohrkerns (GN100). Schwerpunkt ist hierbei die Kl{\"a}rung der Sedimentherkunft innerhalb des Bohrkerns sowie die Ausweisung von Herkunftssignalen und m{\"o}glichen Sedimentquellen bzw. Sedimenttransportpfaden. Die methodische Herangehensweise basiert auf einem Multi-Proxy-Ansatz zur Charakterisierung der klastischen Sedimentfazies anhand von Gel{\"a}ndebeobachtungen, lithologisch-granulometrischen und mineralogisch-geochemischen Analysen sowie statistischen Verfahren. F{\"u}r die mineralogischen Untersuchungen der Sedimente wurde eine neue, rasterelektronenmikroskopische Methode zur automatisierten Partikelanalyse genutzt und den traditionellen Methoden gegen{\"u}bergestellt. Die synoptische Betrachtung der granulometrischen, geochemischen und mineralogischen Befunde der Oberfl{\"a}chensedimente ergibt f{\"u}r das Untersuchungsgebiet ein logisches Kaskadenmodell mit immer wiederkehrenden Prozessbereichen und {\"a}hnlichen Prozesssignalen. Die umfangreichen granulometrischen Analysen deuten dabei auf abnehmende Korngr{\"o}ßen mit zunehmender Entfernung vom Qilian Shan hin und erm{\"o}glichen die Identifizierung von vier texturellen Signalen: den fluvialen Sanden, den D{\"u}nensanden, den Stillwassersedimenten und St{\"a}uben. Diese Ergebnisse k{\"o}nnen als Interpretationsgrundlage f{\"u}r die Korngr{\"o}ßenanalysen des Bohrkerns genutzt werden. Somit ist es m{\"o}glich, die Ablagerungsgeschichte der Bohrkernsedimente zu rekonstruieren und in Verbindung mit eigenen und literaturbasierten Datierungen in einen Gesamtkontext einzuh{\"a}ngen. F{\"u}r das Untersuchungsgebiet werden somit vier Ablagerungsphasen ausgewiesen, die bis in die Zeit des letzten glazialen Maximums (LGM) zur{\"u}ckreichen. W{\"a}hrend dieser Ablagerungsphasen kam es im Zuge unterschiedlicher Aktivit{\"a}ts- und Stabilit{\"a}tsphasen zu einer kontinuierlichen Progradation und {\"U}berpr{\"a}gung des Schwemmf{\"a}chers. Eine besonders aktive Phase kann zwischen 8 ka und 4 ka BP festgestellt werden, w{\"a}hrend der es aufgrund zunehmender fluvialer Aktivit{\"a}ten zu einer deutlich verst{\"a}rkten Schwemmf{\"a}cherdynamik gekommen zu sein scheint. In den Abschnitten davor und danach waren es vor allem {\"a}olische Prozesse, die zu einer {\"U}berpr{\"a}gung des Schwemmf{\"a}chers gef{\"u}hrt haben. Hinsichtlich der mineralogischen Herkunftssignale gibt es eine große Variabilit{\"a}t. Dies spiegelt die enorme Heterogenit{\"a}t der Geologie des Untersuchungsgebietes wider, wodurch die r{\"a}umlichen Signale nicht sehr stark ausgepr{\"a}gt sind. Dennoch, k{\"o}nnen f{\"u}r das Einzugsgebiet drei gr{\"o}ßere Bereiche deklariert werden, die als Herkunftsgebiet in Frage kommen. Das {\"o}stliche Qilian Shan Vorland zeichnet sich dabei durch deutlich h{\"o}here Chloritgehalte als prim{\"a}re Quelle f{\"u}r die Sedimente im Ejina-Becken aus. Sie unterscheiden sich insbesondere durch stark divergierende Chloritgehalte in der Tonmineral- und Gesamtmineralfraktion, was das {\"o}stliche Qilian Shan Vorland als prim{\"a}re Quelle f{\"u}r die Sedimente im Ejina-Becken auszeichnet. Dies steht in Zusammenhang mit den Gr{\"u}nschiefern, Ophioliten und Serpentiniten in diesem Bereich. Geochemisch deutet vor allem das Cr/Rb-Verh{\"a}ltnis eine große Variabilit{\"a}t innerhalb des Einzugsgebietes an. Auch hier ist es das {\"o}stliche Vorland, welches aufgrund seines hohen Anteils an mafischen Gesteinen reich an Chromiten und Spinellen ist und sich somit vom restlichen Untersuchungsgebiet abhebt. Die zeitliche aber auch die generelle Variabilit{\"a}t der Sedimentherkunft l{\"a}sst sich in den Bohrkernsedimenten nicht so deutlich nachzeichnen. Die mineralogisch-sedimentologischen Eigenschaften der erbohrten klastischen Sedimente zeugen zwar von zwischenzeitlichen {\"A}nderungen bei der Sedimentherkunft, diese sind jedoch nicht so deutlich ausgepr{\"a}gt, wie es die Quellsignale in den Oberfl{\"a}chensedimenten vermuten lassen. Ein Grund daf{\"u}r scheint die starke Vermischung unterschiedlichster Sedimente w{\"a}hrend des Transportes zu sein. Die Kombination der Korngr{\"o}ßenergebnisse mit den Befunden der Gesamt- und Schwermineralogie deuten darauf hin, dass es zwischenzeitlich eine Phase mit {\"u}berwiegend {\"a}olischen Prozessen gegeben hat, die mit einem Sedimenteintrag aus dem westlichen Bei Shan in Verbindung stehen. Neben der Zunahme ultrastabiler Schwerminerale wie Zirkon und Granat und der Abnahme opaker Schwerminerale, weisen vor allem die heutigen Verh{\"a}ltnisse darauf hin. Der Vergleich der traditionellen Schwermineralanalyse mit der Computer-Controlled-Scanning-Electron-Microscopy (kurz: CCSEM), die eine automatisierte Partikelauswertung der Proben erm{\"o}glicht, zeigt den deutlichen Vorteil der modernen Analysemethode. Neben einem zeitlichen Vorteil, den man durch die automatisierte Abarbeitung der vorbereiteten Proben erlangen kann, steht vor allem die deutlich gr{\"o}ßere statistische Signifikanz des Ergebnisses im Vordergrund. Zudem k{\"o}nnen mit dieser Methode auch chemische Variet{\"a}ten einiger Schwerminerale bestimmt werden, die eine noch feinere Klassifizierung und sicherere Aussagen zu einer m{\"o}glichen Sedimentherkunft erm{\"o}glichen. Damit ergeben sich außerdem verbesserte Aussagen zu Zusammensetzungen und Entstehungsprozessen der abgelagerten Sedimente. Die Studie verdeutlicht, dass die Sedimentherkunft innerhalb des Untersuchungsgebietes sowie die ablaufenden Prozesse zum Teil stark von lokalen Gegebenheiten abh{\"a}ngen. Die Heterogenit{\"a}t der Geologie und die Gr{\"o}ße des Einzugsgebietes sowie die daraus resultierende Komplexit{\"a}t der Sedimentgenese, machen exakte Zuordnungen zu klar definierten Sedimentquellen sehr schwer. Dennoch zeigen die Ergebnisse, dass die Sedimentzufuhr in das Ejina-Becken in erster Linie durch fluviale klastische Sedimente des Heihe aus dem Qilian Shan erfolgt sein muss. Die Untersuchungsergebnisse zeigen jedoch ebenso die Notwendigkeit einer erg{\"a}nzenden Bearbeitung angrenzender Untersuchungsgebiete, wie beispielsweise den Gobi-Altai im Norden oder den Beishan im Westen, sowie die Verdichtung der Oberfl{\"a}chenbeprobung zur feineren Aufl{\"o}sung von lokalen Sedimentquellen.}, language = {de} } @article{TofeldeBufeTurowski2022, author = {Tofelde, Stefanie and Bufe, Aaron and Turowski, Jens M.}, title = {Hillslope Sediment Supply Limits Alluvial Valley Width}, series = {AGU Advances}, journal = {AGU Advances}, publisher = {American Geophysical Union (AGU); Wiley}, address = {Hoboken, New Jersey, USA}, issn = {2576-604X}, doi = {10.1029/2021AV000641}, pages = {20}, year = {2022}, abstract = {River-valley morphology preserves information on tectonic and climatic conditions that shape landscapes. Observations suggest that river discharge and valley-wall lithology are the main controls on valley width. Yet, current models based on these observations fail to explain the full range of cross-sectional valley shapes in nature, suggesting hitherto unquantified controls on valley width. In particular, current models cannot explain the existence of paired terrace sequences that form under cyclic climate forcing. Paired river terraces are staircases of abandoned floodplains on both valley sides, and hence preserve past valley widths. Their formation requires alternating phases of predominantly river incision and predominantly lateral planation, plus progressive valley narrowing. While cyclic Quaternary climate changes can explain shifts between incision and lateral erosion, the driving mechanism of valley narrowing is unknown. Here, we extract valley geometries from climatically formed, alluvial river-terrace sequences and show that across our dataset, the total cumulative terrace height (here: total valley height) explains 90\%-99\% of the variance in valley width at the terrace sites. This finding suggests that valley height, or a parameter that scales linearly with valley height, controls valley width in addition to river discharge and lithology. To explain this valley-width-height relationship, we reformulate existing valley-width models and suggest that, when adjusting to new boundary conditions, alluvial valleys evolve to a width at which sediment removal from valley walls matches lateral sediment supply from hillslope erosion. Such a hillslope-channel coupling is not captured in current valley-evolution models. Our model can explain the existence of paired terrace sequences under cyclic climate forcing and relates valley width to measurable field parameters. Therefore, it facilitates the reconstruction of past climatic and tectonic conditions from valley topography.}, language = {en} } @article{MiklashevskyFischerLindemann2022, author = {Miklashevsky, Alex and Fischer, Martin H. and Lindemann, Oliver}, title = {Spatial-numerical associations without a motor response? Grip force says 'Yes'}, series = {Acta Psychologica}, volume = {231}, journal = {Acta Psychologica}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1873-6297}, doi = {10.1016/j.actpsy.2022.103791}, pages = {1 -- 17}, year = {2022}, abstract = {In numerical processing, the functional role of Spatial-Numerical Associations (SNAs, such as the association of smaller numbers with left space and larger numbers with right space, the Mental Number Line hypothesis) is debated. Most studies demonstrate SNAs with lateralized responses, and there is little evidence that SNAs appear when no response is required. We recorded passive holding grip forces in no-go trials during number processing. In Experiment 1, participants performed a surface numerical decision task ("Is it a number or a letter?"). In Experiment 2, we used a deeper semantic task ("Is this number larger or smaller than five?"). Despite instruction to keep their grip force constant, participants' spontaneous grip force changed in both experiments: Smaller numbers led to larger force increase in the left than in the right hand in the numerical decision task (500-700 ms after stimulus onset). In the semantic task, smaller numbers again led to larger force increase in the left hand, and larger numbers increased the right-hand holding force. This effect appeared earlier (180 ms) and lasted longer (until 580 ms after stimulus onset). This is the first demonstration of SNAs with passive holding force. Our result suggests that (1) explicit motor response is not a prerequisite for SNAs to appear, and (2) the timing and strength of SNAs are task-dependent. (216 words).}, language = {en} } @techreport{KienbaumFischerPassmann2023, type = {Working Paper}, author = {Kienbaum, Janna and Fischer, Patryk and Passmann, Sven}, title = {Forschungsdatenmanagement bei personenbezogenen Daten}, doi = {10.5281/zenodo.7428524}, pages = {18}, year = {2023}, abstract = {Das Dokument "Forschungsdatenmanagement bei personenbezogenen Daten - eine Handreichung" versammelt zentrale Inhalte, Verweise und Vorgehensweisen f{\"u}r Forscher*innen, die in einer Studie personenbezogene Daten erheben und diese verarbeiten, archivieren oder ver{\"o}ffentlichen wollen. Die Handreichung verweist an den entsprechenden Abschnitten auf weiterf{\"u}hrende Materialien wie insbesondere die Handreichung „Datenschutz" des Rats f{\"u}r die Sozial-, Verhaltens-, Bildungs- und Wirtschaftswissenschaften (RatSWD).}, language = {de} } @techreport{KienbaumWuerflFavella2022, type = {Working Paper}, author = {Kienbaum, Janna and W{\"u}rfl, Katja and Favella, Gianpiero}, title = {Leitfaden f{\"u}r einen qualitativen Methoden- und Feldbericht}, doi = {10.5281/zenodo.7247993}, pages = {12}, year = {2022}, abstract = {Der Leitfaden f{\"u}r einen qualitativen Methoden- und Feldbericht ist im Rahmen des DFG-Verbundprojektes "FDNext" (2020-2023) entstanden und dient als Orientierungshilfe f{\"u}r die Dokumentation erhobener Daten mit dem Schwerpunkt auf die qualitative Bildungsforschung.}, language = {de} } @article{LindnerMoellerHildebrandtetal.2022, author = {Lindner, Nadja and Moeller, Korbinian and Hildebrandt, Frauke and Hasselhorn, Marcus and Lonnemann, Jan}, title = {Children's use of egocentric reference frames in spatial language is related to their numerical magnitude understanding}, series = {Frontiers in Psychology}, journal = {Frontiers in Psychology}, publisher = {Frontiers}, address = {Lausanne, Schweiz}, issn = {1664-1078}, doi = {10.3389/fpsyg.2022.943191}, pages = {1 -- 13}, year = {2022}, abstract = {Numerical magnitude information is assumed to be spatially represented in the form of a mental number line defined with respect to a body-centred, egocentric frame of reference. In this context, spatial language skills such as mastery of verbal descriptions of spatial position (e.g., in front of, behind, to the right/left) have been proposed to be relevant for grasping spatial relations between numerical magnitudes on the mental number line. We examined 4- to 5-year-old's spatial language skills in tasks that allow responses in egocentric and allocentric frames of reference, as well as their relative understanding of numerical magnitude (assessed by a number word comparison task). In addition, we evaluated influences of children's absolute understanding of numerical magnitude assessed by their number word comprehension (montring different numbers using their fingers) and of their knowledge on numerical sequences (determining predecessors and successors as well as identifying missing dice patterns of a series). Results indicated that when considering responses that corresponded to the egocentric perspective, children's spatial language was associated significantly with their relative numerical magnitude understanding, even after controlling for covariates, such as children's SES, mental rotation skills, and also absolute magnitude understanding or knowledge on numerical sequences. This suggests that the use of egocentric reference frames in spatial language may facilitate spatial representation of numbers along a mental number line and thus seem important for preschoolers' relative understanding of numerical magnitude.}, language = {en} } @article{HeckerSteckhanEybenetal.2022, author = {Hecker, Pascal and Steckhan, Nico and Eyben, Florian and Schuller, Bj{\"o}rn Wolfgang and Arnrich, Bert}, title = {Voice Analysis for Neurological Disorder Recognition - A Systematic Review and Perspective on Emerging Trends}, series = {Frontiers in Digital Health}, journal = {Frontiers in Digital Health}, publisher = {Frontiers Media SA}, address = {Lausanne, Schweiz}, issn = {2673-253X}, doi = {10.3389/fdgth.2022.842301}, pages = {16}, year = {2022}, abstract = {Quantifying neurological disorders from voice is a rapidly growing field of research and holds promise for unobtrusive and large-scale disorder monitoring. The data recording setup and data analysis pipelines are both crucial aspects to effectively obtain relevant information from participants. Therefore, we performed a systematic review to provide a high-level overview of practices across various neurological disorders and highlight emerging trends. PRISMA-based literature searches were conducted through PubMed, Web of Science, and IEEE Xplore to identify publications in which original (i.e., newly recorded) datasets were collected. Disorders of interest were psychiatric as well as neurodegenerative disorders, such as bipolar disorder, depression, and stress, as well as amyotrophic lateral sclerosis amyotrophic lateral sclerosis, Alzheimer's, and Parkinson's disease, and speech impairments (aphasia, dysarthria, and dysphonia). Of the 43 retrieved studies, Parkinson's disease is represented most prominently with 19 discovered datasets. Free speech and read speech tasks are most commonly used across disorders. Besides popular feature extraction toolkits, many studies utilise custom-built feature sets. Correlations of acoustic features with psychiatric and neurodegenerative disorders are presented. In terms of analysis, statistical analysis for significance of individual features is commonly used, as well as predictive modeling approaches, especially with support vector machines and a small number of artificial neural networks. An emerging trend and recommendation for future studies is to collect data in everyday life to facilitate longitudinal data collection and to capture the behavior of participants more naturally. Another emerging trend is to record additional modalities to voice, which can potentially increase analytical performance.}, language = {en} } @inproceedings{CurzonKalasSchubertetal.2015, author = {Curzon, Paul and Kalas, Ivan and Schubert, Sigrid and Schaper, Niclas and Barnes, Jan and Kennewell, Steve and Br{\"o}ker, Kathrin and Kastens, Uwe and Magenheim, Johannes and Dagiene, Valentina and Stupuriene, Gabriele and Ellis, Jason Brent and Abreu-Ellis, Carla Reis and Grillenberger, Andreas and Romeike, Ralf and Haugsbakken, Halvdan and Jones, Anthony and Lewin, Cathy and McNicol, Sarah and Nelles, Wolfgang and Neugebauer, Jonas and Ohrndorf, Laura and Schaper, Niclas and Schubert, Sigrid and Opel, Simone and Kramer, Matthias and Trommen, Michael and Pottb{\"a}cker, Florian and Ilaghef, Youssef and Passig, David and Tzuriel, David and Kedmi, Ganit Eshel and Saito, Toshinori and Webb, Mary and Weigend, Michael and Bottino, Rosa and Chioccariello, Augusto and Christensen, Rhonda and Knezek, Gerald and Gioko, Anthony Maina and Angondi, Enos Kiforo and Waga, Rosemary and Ohrndorf, Laura and Or-Bach, Rachel and Preston, Christina and Younie, Sarah and Przybylla, Mareen and Romeike, Ralf and Reynolds, Nicholas and Swainston, Andrew and Bendrups, Faye and Sysło, Maciej M. and Kwiatkowska, Anna Beata and Zieris, Holger and Gerstberger, Herbert and M{\"u}ller, Wolfgang and B{\"u}chner, Steffen and Opel, Simone and Schiller, Thomas and Wegner, Christian and Zender, Raphael and Lucke, Ulrike and Diethelm, Ira and Syrbe, J{\"o}rn and Lai, Kwok-Wing and Davis, Niki and Eickelmann, Birgit and Erstad, Ola and Fisser, Petra and Gibson, David and Khaddage, Ferial and Knezek, Gerald and Micheuz, Peter and Kloos, Carlos Delgado}, title = {KEYCIT 2014}, editor = {Brinda, Torsten and Reynolds, Nicholas and Romeike, Ralf and Schwill, Andreas}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-292-6}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-70325}, pages = {438}, year = {2015}, abstract = {In our rapidly changing world it is increasingly important not only to be an expert in a chosen field of study but also to be able to respond to developments, master new approaches to solving problems, and fulfil changing requirements in the modern world and in the job market. In response to these needs key competencies in understanding, developing and using new digital technologies are being brought into focus in school and university programmes. The IFIP TC3 conference "KEYCIT - Key Competences in Informatics and ICT (KEYCIT 2014)" was held at the University of Potsdam in Germany from July 1st to 4th, 2014 and addressed the combination of key competencies, Informatics and ICT in detail. The conference was organized into strands focusing on secondary education, university education and teacher education (organized by IFIP WGs 3.1 and 3.3) and provided a forum to present and to discuss research, case studies, positions, and national perspectives in this field.}, language = {en} } @article{OgunkolaGuiraudieCaprazFeronetal.2023, author = {Ogunkola, Moses Olalekan and Guiraudie-Capraz, Gaelle and F{\´e}ron, Fran{\c{c}}ois and Leimk{\"u}hler, Silke}, title = {The Human Mercaptopyruvate Sulfurtransferase TUM1 Is Involved in Moco Biosynthesis, Cytosolic tRNA Thiolation and Cellular Bioenergetics in Human Embryonic Kidney Cells}, series = {Biomolecules}, volume = {13}, journal = {Biomolecules}, edition = {1}, publisher = {MDPI}, address = {Basel, Schweiz}, issn = {2218-273X}, doi = {10.3390/biom13010144}, pages = {1 -- 23}, year = {2023}, abstract = {Sulfur is an important element that is incorporated into many biomolecules in humans. The incorporation and transfer of sulfur into biomolecules is, however, facilitated by a series of different sulfurtransferases. Among these sulfurtransferases is the human mercaptopyruvate sulfurtransferase (MPST) also designated as tRNA thiouridine modification protein (TUM1). The role of the human TUM1 protein has been suggested in a wide range of physiological processes in the cell among which are but not limited to involvement in Molybdenum cofactor (Moco) biosynthesis, cytosolic tRNA thiolation and generation of H2S as signaling molecule both in mitochondria and the cytosol. Previous interaction studies showed that TUM1 interacts with the L-cysteine desulfurase NFS1 and the Molybdenum cofactor biosynthesis protein 3 (MOCS3). Here, we show the roles of TUM1 in human cells using CRISPR/Cas9 genetically modified Human Embryonic Kidney cells. Here, we show that TUM1 is involved in the sulfur transfer for Molybdenum cofactor synthesis and tRNA thiomodification by spectrophotometric measurement of the activity of sulfite oxidase and liquid chromatography quantification of the level of sulfur-modified tRNA. Further, we show that TUM1 has a role in hydrogen sulfide production and cellular bioenergetics.}, language = {en} } @article{GoeldelKamrathMindenetal.2022, author = {G{\"o}ldel, Julia M. and Kamrath, Clemens and Minden, Kirsten and Wiegand, Susanna and Lanzinger, Stefanie and Sengler, Claudia and Weihrauch-Bl{\"u}her, Susann and Holl, Reinhard W. and Tittel, Sascha Ren{\´e} and Warschburger, Petra}, title = {Access to Healthcare for Children and Adolescents with a Chronic Health Condition during the COVID-19 Pandemic: First Results from the KICK-COVID Study in Germany}, series = {Children}, volume = {10}, journal = {Children}, edition = {1}, publisher = {MDPI}, address = {Basel, Schweiz}, issn = {2227-9067}, doi = {10.3390/children10010010}, pages = {1 -- 11}, year = {2022}, abstract = {This study examines the access to healthcare for children and adolescents with three common chronic diseases (type-1 diabetes (T1D), obesity, or juvenile idiopathic arthritis (JIA)) within the 4th (Delta), 5th (Omicron), and beginning of the 6th (Omicron) wave (June 2021 until July 2022) of the COVID-19 pandemic in Germany in a cross-sectional study using three national patient registries. A paper-and-pencil questionnaire was given to parents of pediatric patients (<21 years) during the routine check-ups. The questionnaire contains self-constructed items assessing the frequency of healthcare appointments and cancellations, remote healthcare, and satisfaction with healthcare. In total, 905 parents participated in the T1D-sample, 175 in the obesity-sample, and 786 in the JIA-sample. In general, satisfaction with healthcare (scale: 0-10; 10 reflecting the highest satisfaction) was quite high (median values: T1D 10, JIA 10, obesity 8.5). The proportion of children and adolescents with canceled appointments was relatively small (T1D 14.1\%, JIA 11.1\%, obesity 20\%), with a median of 1 missed appointment, respectively. Only a few parents (T1D 8.6\%; obesity 13.1\%; JIA 5\%) reported obstacles regarding health services during the pandemic. To conclude, it seems that access to healthcare was largely preserved for children and adolescents with chronic health conditions during the COVID-19 pandemic in Germany.}, language = {en} } @article{MarggrafLindeckeVoigtetal.2023, author = {Marggraf, Lara Christin and Lindecke, Oliver and Voigt, Christian C. and Pētersons, Gunārs and Voigt-Heucke, Silke Luise}, title = {Nathusius' bats, Pipistrellus nathusii, bypass mating opportunities of their own species, but respond to foraging heterospecifics on migratory transit flights}, series = {Frontiers in Ecology and Evolution}, journal = {Frontiers in Ecology and Evolution}, publisher = {Frontiers}, address = {Lausanne, Schweiz}, issn = {2296-701X}, doi = {10.3389/fevo.2022.908560}, pages = {1 -- 10}, year = {2023}, abstract = {In late summer, migratory bats of the temperate zone face the challenge of accomplishing two energy-demanding tasks almost at the same time: migration and mating. Both require information and involve search efforts, such as localizing prey or finding potential mates. In non-migrating bat species, playback studies showed that listening to vocalizations of other bats, both con-and heterospecifics, may help a recipient bat to find foraging patches and mating sites. However, we are still unaware of the degree to which migrating bats depend on con-or heterospecific vocalizations for identifying potential feeding or mating opportunities during nightly transit flights. Here, we investigated the vocal responses of Nathusius' pipistrelle bats, Pipistrellus nathusii, to simulated feeding and courtship aggregations at a coastal migration corridor. We presented migrating bats either feeding buzzes or courtship calls of their own or a heterospecific migratory species, the common noctule, Nyctalus noctula. We expected that during migratory transit flights, simulated feeding opportunities would be particularly attractive to bats, as well as simulated mating opportunities which may indicate suitable roosts for a stopover. However, we found that when compared to the natural silence of both pre-and post-playback phases, bats called indifferently during the playback of conspecific feeding sounds, whereas P. nathusii echolocation call activity increased during simulated feeding of N. noctula. In contrast, the call activity of P. nathusii decreased during the playback of conspecific courtship calls, while no response could be detected when heterospecific call types were broadcasted. Our results suggest that while on migratory transits, P. nathusii circumnavigate conspecific mating aggregations, possibly to save time or to reduce the risks associated with social interactions where aggression due to territoriality might be expected. This avoidance behavior could be a result of optimization strategies by P. nathusii when performing long-distance migratory flights, and it could also explain the lack of a response to simulated conspecific feeding. However, the observed increase of activity in response to simulated feeding of N. noctula, suggests that P. nathusii individuals may be eavesdropping on other aerial hawking insectivorous species during migration, especially if these occupy a slightly different foraging niche.}, language = {en} } @article{Doerfler2005, author = {D{\"o}rfler, Thomas}, title = {Geographie und Dekonstruktion}, series = {Geographische Revue : Zeitschrift f{\"u}r Literatur und Diskussion}, volume = {7}, journal = {Geographische Revue : Zeitschrift f{\"u}r Literatur und Diskussion}, number = {1/2}, issn = {1438-3039}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-31098}, pages = {67 -- 85}, year = {2005}, abstract = {Inhalt: - Der Ort - Das Symptom - Der Jargon des Vermeintlichen, oder: vermeintliche Philosophie - Was ist: Dekonstruktion? - Zur Genese - Dekonstruktion und Geographie - Grenz-Philosophie - Die Welt als Text - Versuch {\"u}ber die Grenze, in geographischer Absicht}, language = {de} } @article{KuehneFauthDestinaSevdeetal.2021, author = {K{\"u}hne, Franziska and Fauth, Henriette and Destina Sevde, Ay-Bryson and Visser, Leonie N.C. and Weck, Florian}, title = {Communicating the diagnosis of cancer or depression: Results of a randomized controlled online study using video vignettes}, series = {Cancer Medicine}, volume = {10}, journal = {Cancer Medicine}, edition = {24}, publisher = {Wiley}, address = {Hoboken, New Jersey, USA}, issn = {2045-7634}, doi = {10.1002/cam4.4396}, pages = {9012 -- 9021}, year = {2021}, abstract = {Background Communicating a diagnosis is highly important, yet complex, especially in the context of cancer and mental disorders. The aim was to explore the communication style of an oncologist vs. psychotherapist in an online study. Methods Patients (N = 136: 65 cancer, 71 depression) were randomly assigned to watch a standardized video vignette with one of two communication styles (empathic vs. unempathic). Outcome measures of affectivity, information recall, communication skills, empathy and trust were applied. Results Regardless of diagnosis, empathic communication was associated with the perception of a significantly more empathic (p < 0.001, η2partial = 0.08) and trustworthy practitioner (p = 0.014, η2partial = 0.04) with better communication skills (p = 0.013, η2partial = 0.05). Cancer patients reported a larger decrease in positive affect (p < 0.001, η2partial = 0.15) and a larger increase in negative affect (p < 0.001, η2partial = 0.14) from pre- to post-video than depressive patients. Highly relevant information was recalled better in both groups (p < 0.001, d = 0.61-1.06). Conclusions The results highlight the importance of empathy while communicating both a diagnosis of cancer and a mental disorder. Further research should focus on the communication of a mental disorder in association with cancer.}, language = {en} } @book{CeglarekWulschFrenzeletal.2006, author = {Ceglarek, Petra and Wulsch, Iris and Frenzel, Tom and Ihle, Wolfgang}, title = {Gesundheitsf{\"o}rderung in Brandenburger Kindertagesst{\"a}tten : eine Bestandsaufnahme}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-939469-50-6}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-13105}, publisher = {Universit{\"a}t Potsdam}, pages = {112}, year = {2006}, abstract = {Theoretischer Hintergrund: Eine fr{\"u}hzeitige Gesundheitsf{\"o}rderung wird als wesentliches Bestimmungsst{\"u}ck zur Pr{\"a}vention k{\"o}rperlicher und psychischer Erkrankungen angesehen. Als ideales Setting f{\"u}r eine gezielte Gesundheitsf{\"o}rderung wird der Lebensraum Kita angesehen. Fragestellungen: Welche Aktivit{\"a}ten zur Gesundheitsf{\"o}rderung gibt es bisher in den Brandenburger Kitas? Spielt hier die Bildungsn{\"a}he/-ferne der betreuten Kinder eine Rolle? In welchen Bereichen gibt es den gr{\"o}ßten Fort- und Weiterbildungsbedarf der Mitarbeiterinnen? Methode: Untersuchung einer Stichprobe von 269 Brandenburger Kitas mit insgesamt 21 653 betreuten Kindern. Erfassung struktureller Rahmenbedingungen, p{\"a}dagogischer Konzepte, Aktivit{\"a}ten zur Gesundheitsf{\"o}rderung, Partizipation und Fortbildungsbedarf. Ergebnisse: Es zeigte sich eine nachhaltige Umsetzung von Aktivit{\"a}ten und große Kreativit{\"a}t. Dabei standen vor allem Angebote der Bereiche Bewegung und Ern{\"a}hrung im Zentrum. Psychosoziale Themen wurden seltener als Schwerpunkt benannt, wohingegen hierf{\"u}r der gr{\"o}ßte Fortbildungbedarf (Ranking der Fortbildungsthemen: 1. Psychosoziale Entwicklung, 2. Psychische Probleme, 3. Stressbew{\"a}ltigung) vorlag.}, language = {de} } @article{ReegStriglJeltsch2022, author = {Reeg, Jette and Strigl, Lea and Jeltsch, Florian}, title = {Agricultural buffer zone thresholds to safeguard functional bee diversity}, series = {Ecology and Evolution}, volume = {12}, journal = {Ecology and Evolution}, edition = {3}, publisher = {Wiley Online Library}, address = {Hoboken, New Jersey, USA}, issn = {2045-7758}, doi = {10.1002/ece3.8748}, pages = {1 -- 17}, year = {2022}, abstract = {Wild bee species are important pollinators in agricultural landscapes. However, population decline was reported over the last decades and is still ongoing. While agricultural intensification is a major driver of the rapid loss of pollinating species, transition zones between arable fields and forest or grassland patches, i.e., agricultural buffer zones, are frequently mentioned as suitable mitigation measures to support wild bee populations and other pollinator species. Despite the reported general positive effect, it remains unclear which amount of buffer zones is needed to ensure a sustainable and permanent impact for enhancing bee diversity and abundance. To address this question at a pollinator community level, we implemented a process-based, spatially explicit simulation model of functional bee diversity dynamics in an agricultural landscape. More specifically, we introduced a variable amount of agricultural buffer zones (ABZs) at the transition of arable to grassland, or arable to forest patches to analyze the impact on bee functional diversity and functional richness. We focused our study on solitary bees in a typical agricultural area in the Northeast of Germany. Our results showed positive effects with at least 25\% of virtually implemented agricultural buffer zones. However, higher amounts of ABZs of at least 75\% should be considered to ensure a sufficient increase in Shannon diversity and decrease in quasi-extinction risks. These high amounts of ABZs represent effective conservation measures to safeguard the stability of pollination services provided by solitary bee species. As the model structure can be easily adapted to other mobile species in agricultural landscapes, our community approach offers the chance to compare the effectiveness of conservation measures also for other pollinator communities in future.}, language = {en} } @article{ZieglerPfitznerSchulzetal.2022, author = {Ziegler, Joceline and Pfitzner, Bjarne and Schulz, Heinrich and Saalbach, Axel and Arnrich, Bert}, title = {Defending against Reconstruction Attacks through Differentially Private Federated Learning for Classification of Heterogeneous Chest X-ray Data}, series = {Sensors}, volume = {22}, journal = {Sensors}, edition = {14}, publisher = {MDPI}, address = {Basel, Schweiz}, issn = {1424-8220}, doi = {10.3390/s22145195}, pages = {25}, year = {2022}, abstract = {Privacy regulations and the physical distribution of heterogeneous data are often primary concerns for the development of deep learning models in a medical context. This paper evaluates the feasibility of differentially private federated learning for chest X-ray classification as a defense against data privacy attacks. To the best of our knowledge, we are the first to directly compare the impact of differentially private training on two different neural network architectures, DenseNet121 and ResNet50. Extending the federated learning environments previously analyzed in terms of privacy, we simulated a heterogeneous and imbalanced federated setting by distributing images from the public CheXpert and Mendeley chest X-ray datasets unevenly among 36 clients. Both non-private baseline models achieved an area under the receiver operating characteristic curve (AUC) of 0.940.94 on the binary classification task of detecting the presence of a medical finding. We demonstrate that both model architectures are vulnerable to privacy violation by applying image reconstruction attacks to local model updates from individual clients. The attack was particularly successful during later training stages. To mitigate the risk of a privacy breach, we integrated R{\´e}nyi differential privacy with a Gaussian noise mechanism into local model training. We evaluate model performance and attack vulnerability for privacy budgets ε∈{1,3,6,10}�∈{1,3,6,10}. The DenseNet121 achieved the best utility-privacy trade-off with an AUC of 0.940.94 for ε=6�=6. Model performance deteriorated slightly for individual clients compared to the non-private baseline. The ResNet50 only reached an AUC of 0.760.76 in the same privacy setting. Its performance was inferior to that of the DenseNet121 for all considered privacy constraints, suggesting that the DenseNet121 architecture is more robust to differentially private training.}, language = {en} } @article{LiebeDordevicKaufmannetal.2022, author = {Liebe, Thomas and Dordevic, Milos and Kaufmann, J{\"o}rn and Avetisyan, Araks and Skalej, Martin and M{\"u}ller, Notger Germar}, title = {Investigation of the functional pathogenesis of mild cognitive impairment by localisation-based locus coeruleus resting-state fMRI}, series = {Human Brain Mapping}, volume = {43}, journal = {Human Brain Mapping}, edition = {18}, publisher = {Wiley}, address = {New York, NY, USA}, issn = {1097-0193}, doi = {10.1002/hbm.26039}, pages = {5630 -- 5642}, year = {2022}, abstract = {Dementia as one of the most prevalent diseases urges for a better understanding of the central mechanisms responsible for clinical symptoms, and necessitates improvement of actual diagnostic capabilities. The brainstem nucleus locus coeruleus (LC) is a promising target for early diagnosis because of its early structural alterations and its relationship to the functional disturbances in the patients. In this study, we applied our improved method of localisation-based LC resting-state fMRI to investigate the differences in central sensory signal processing when comparing functional connectivity (fc) of a patient group with mild cognitive impairment (MCI, n = 28) and an age-matched healthy control group (n = 29). MCI and control participants could be differentiated in their Mini-Mental-State-Examination (MMSE) scores (p < .001) and LC intensity ratio (p = .010). In the fMRI, LC fc to anterior cingulate cortex (FDR p < .001) and left anterior insula (FDR p = .012) was elevated, and LC fc to right temporoparietal junction (rTPJ, FDR p = .012) and posterior cingulate cortex (PCC, FDR p = .021) was decreased in the patient group. Importantly, LC to rTPJ connectivity was also positively correlated to MMSE scores in MCI patients (p = .017). Furthermore, we found a hyperactivation of the left-insula salience network in the MCI patients. Our results and our proposed disease model shed new light on the functional pathogenesis of MCI by directing to attentional network disturbances, which could aid new therapeutic strategies and provide a marker for diagnosis and prediction of disease progression.}, language = {en} } @article{HauffeRathAgyapongetal.2022, author = {Hauffe, Robert and Rath, Michaela and Agyapong, Wilson and Jonas, Wenke and Vogel, Heike and Schulz, Tim Julius and Schwarz, Maria and Kipp, Anna Patricia and Bl{\"u}her, Matthias and Kleinridders, Andr{\´e}}, title = {Obesity Hinders the Protective Effect of Selenite Supplementation on Insulin Signaling}, series = {Antioxidants}, volume = {11}, journal = {Antioxidants}, edition = {5}, publisher = {MDPI}, address = {Basel, Schweiz}, issn = {2076-3921}, doi = {10.3390/antiox11050862}, pages = {1 -- 16}, year = {2022}, abstract = {The intake of high-fat diets (HFDs) containing large amounts of saturated long-chain fatty acids leads to obesity, oxidative stress, inflammation, and insulin resistance. The trace element selenium, as a crucial part of antioxidative selenoproteins, can protect against the development of diet-induced insulin resistance in white adipose tissue (WAT) by increasing glutathione peroxidase 3 (GPx3) and insulin receptor (IR) expression. Whether selenite (Se) can attenuate insulin resistance in established lipotoxic and obese conditions is unclear. We confirm that GPX3 mRNA expression in adipose tissue correlates with BMI in humans. Cultivating 3T3-L1 pre-adipocytes in palmitate-containing medium followed by Se treatment attenuates insulin resistance with enhanced GPx3 and IR expression and adipocyte differentiation. However, feeding obese mice a selenium-enriched high-fat diet (SRHFD) only resulted in a modest increase in overall selenoprotein gene expression in WAT in mice with unaltered body weight development, glucose tolerance, and insulin resistance. While Se supplementation improved adipocyte morphology, it did not alter WAT insulin sensitivity. However, mice fed a SRHFD exhibited increased insulin content in the pancreas. Overall, while selenite protects against palmitate-induced insulin resistance in vitro, obesity impedes the effect of selenite on insulin action and adipose tissue metabolism in vivo.}, language = {en} } @article{KayhanMatthesMarriottHaresignetal.2022, author = {Kayhan, Ezgi and Matthes, Daniel and Marriott Haresign, Ira and B{\´a}nki, Anna and Michel, Christine and Langeloh, Miriam and Wass, Sam and Hoehl, Stefanie}, title = {DEEP: A dual EEG pipeline for developmental hyperscanning studies}, series = {Developmental Cognitive Neuroscience}, volume = {54}, journal = {Developmental Cognitive Neuroscience}, publisher = {Elsevier}, address = {Amsterdam, Niederlande}, issn = {1878-9307}, doi = {10.1016/j.dcn.2022.101104}, pages = {1 -- 11}, year = {2022}, abstract = {Cutting-edge hyperscanning methods led to a paradigm shift in social neuroscience. It allowed researchers to measure dynamic mutual alignment of neural processes between two or more individuals in naturalistic contexts. The ever-growing interest in hyperscanning research calls for the development of transparent and validated data analysis methods to further advance the field. We have developed and tested a dual electroencephalography (EEG) analysis pipeline, namely DEEP. Following the preprocessing of the data, DEEP allows users to calculate Phase Locking Values (PLVs) and cross-frequency PLVs as indices of inter-brain phase alignment of dyads as well as time-frequency responses and EEG power for each participant. The pipeline also includes scripts to control for spurious correlations. Our goal is to contribute to open and reproducible science practices by making DEEP publicly available together with an example mother-infant EEG hyperscanning dataset.}, language = {en} } @article{TiedemannIobbiNivolLeimkuehler2022, author = {Tiedemann, Kim and Iobbi-Nivol, Chantal and Leimk{\"u}hler, Silke}, title = {The Role of the Nucleotides in the Insertion of the bis-Molybdopterin Guanine Dinucleotide Cofactor into apo-Molybdoenzymes}, series = {Molecules}, volume = {27}, journal = {Molecules}, edition = {9}, publisher = {MDPI}, address = {Basel, Schweiz}, issn = {1420-3049}, doi = {10.3390/molecules27092993}, pages = {1 -- 15}, year = {2022}, abstract = {The role of the GMP nucleotides of the bis-molybdopterin guanine dinucleotide (bis-MGD) cofactor of the DMSO reductase family has long been a subject of discussion. The recent characterization of the bis-molybdopterin (bis-Mo-MPT) cofactor present in the E. coli YdhV protein, which differs from bis-MGD solely by the absence of the nucleotides, now enables studying the role of the nucleotides of bis-MGD and bis-MPT cofactors in Moco insertion and the activity of molybdoenzymes in direct comparison. Using the well-known E. coli TMAO reductase TorA as a model enzyme for cofactor insertion, we were able to show that the GMP nucleotides of bis-MGD are crucial for the insertion of the bis-MGD cofactor into apo-TorA.}, language = {en} } @inproceedings{ReimerAharonianHintonetal.2007, author = {Reimer, O. and Aharonian, Felix A. and Hinton, J. and Hofmann, W. and Hoppe, S. and Raue, M. and Reimer, A.}, title = {VHE gamma-rays from Westerlund 2 and implications for the inferred energetics}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-18172}, year = {2007}, abstract = {The H.E.S.S. collaboration recently reported the discovery of VHE γ-ray emission coincident with the young stellar cluster Westerlund 2. This system is known to host a population of hot, massive stars, and, most particularly, the WR binary WR 20a. Particle acceleration to TeV energies in Westerlund 2 can be accomplished in several alternative scenarios, therefore we only discuss energetic constraints based on the total available kinetic energy in the system, the actual mass loss rates of respective cluster members, and implied gamma-ray production from processes such as inverse Compton scattering or neutral pion decay. From the inferred gammaray luminosity of the order of 1035erg/s, implications for the efficiency of converting available kinetic energy into non-thermal radiation associated with stellar winds in the Westerlund 2 cluster are discussed under consideration of either the presence or absence of wind clumping.}, language = {en} } @article{WeithoffBell2022, author = {Weithoff, Guntram and Bell, Elanor Margaret}, title = {Complex Trophic Interactions in an Acidophilic Microbial Community}, series = {Microorganisms}, volume = {10}, journal = {Microorganisms}, edition = {7}, publisher = {MDPI}, address = {Basel, Schweiz}, issn = {2076-2607}, doi = {10.3390/microorganisms10071340}, pages = {1 -- 10}, year = {2022}, abstract = {Extreme habitats often harbor specific communities that differ substantially from non-extreme habitats. In many cases, these communities are characterized by archaea, bacteria and protists, whereas the number of species of metazoa and higher plants is relatively low. In extremely acidic habitats, mostly prokaryotes and protists thrive, and only very few metazoa thrive, for example, rotifers. Since many studies have investigated the physiology and ecology of individual species, there is still a gap in research on direct, trophic interactions among extremophiles. To fill this gap, we experimentally studied the trophic interactions between a predatory protist (Actinophrys sol, Heliozoa) and its prey, the rotifers Elosa woralli and Cephalodella sp., the ciliate Urosomoida sp. and the mixotrophic protist Chlamydomonas acidophila (a green phytoflagellate, Chlorophyta). We found substantial predation pressure on all animal prey. High densities of Chlamydomonas acidophila reduced the predation impact on the rotifers by interfering with the feeding behaviour of A. sol. These trophic relations represent a natural case of intraguild predation, with Chlamydomonas acidophila being the common prey and the rotifers/ciliate and A. sol being the intraguild prey and predator, respectively. We further studied this intraguild predation along a resource gradient using Cephalodella sp. as the intraguild prey. The interactions among the three species led to an increase in relative rotifer abundance with increasing resource (Chlamydomonas) densities. By applying a series of laboratory experiments, we revealed the complexity of trophic interactions within a natural extremophilic community.}, language = {en} } @book{WeissVerlaanVasquezCarruthersetal.2022, author = {Weiß, Norman and Verlaan, Stephanie and Vasquez Carruthers, Juan Francisco and Mair, Theresa and Conner, Sean and Maaser, Lucas and R{\"o}thlisberger, Livia}, title = {Transitional Justice}, series = {Potsdamer Studien zu Staat, Recht und Politik}, journal = {Potsdamer Studien zu Staat, Recht und Politik}, number = {7}, editor = {Weiß, Norman}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-473-9}, issn = {1869-2443}, doi = {10.25932/publishup-43171}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-431711}, publisher = {Universit{\"a}t Potsdam}, pages = {194}, year = {2022}, abstract = {This publication deals with the topic of transitional justice. In six case studies, the authors link theoretical and practical implications in order to develop some innovative approaches. Their proposals might help to deal more effectively with the transition of societies, legal orders and political systems. Young academics from various backgrounds provide fresh insights and demonstrate the relevance of the topic. The chapters analyse transitions and conflicts in Sierra Leone, Argentina, Nicaragua, Nepal, and South Sudan as well as Germany's colonial genocide in Namibia. Thus, the book provides the reader with new insights and contributes to the ongoing debate about transitional justice.}, language = {en} } @article{PrasseIversenLienhardetal.2022, author = {Prasse, Paul and Iversen, Pascal and Lienhard, Matthias and Thedinga, Kristina and Herwig, Ralf and Scheffer, Tobias}, title = {Pre-Training on In Vitro and Fine-Tuning on Patient-Derived Data Improves Deep Neural Networks for Anti-Cancer Drug-Sensitivity Prediction}, series = {MDPI}, volume = {14}, journal = {MDPI}, edition = {16}, publisher = {MDPI}, address = {Basel, Schweiz}, issn = {2072-6694}, doi = {10.3390/cancers14163950}, pages = {1 -- 14}, year = {2022}, abstract = {Large-scale databases that report the inhibitory capacities of many combinations of candidate drug compounds and cultivated cancer cell lines have driven the development of preclinical drug-sensitivity models based on machine learning. However, cultivated cell lines have devolved from human cancer cells over years or even decades under selective pressure in culture conditions. Moreover, models that have been trained on in vitro data cannot account for interactions with other types of cells. Drug-response data that are based on patient-derived cell cultures, xenografts, and organoids, on the other hand, are not available in the quantities that are needed to train high-capacity machine-learning models. We found that pre-training deep neural network models of drug sensitivity on in vitro drug-sensitivity databases before fine-tuning the model parameters on patient-derived data improves the models' accuracy and improves the biological plausibility of the features, compared to training only on patient-derived data. From our experiments, we can conclude that pre-trained models outperform models that have been trained on the target domains in the vast majority of cases.}, language = {en} } @article{OmaneHoehle2020, author = {Omane, Paul Okyere and H{\"o}hle, Barbara}, title = {Acquiring syntactic variability}, series = {Frontiers in communication}, volume = {2021}, journal = {Frontiers in communication}, publisher = {Frontiers Media}, address = {Lausanne, Schweiz}, issn = {2297-900X}, doi = {10.3389/fcomm.2021.604951}, pages = {15}, year = {2020}, abstract = {This paper investigates the predictions of the Derivational Complexity Hypothesis by studying the acquisition of wh-questions in 4- and 5-year-old Akan-speaking children in an experimental approach using an elicited production and an elicited imitation task. Akan has two types of wh-question structures (wh-in-situ and wh-ex-situ questions), which allows an investigation of children's acquisition of these two question structures and their preferences for one or the other. Our results show that adults prefer to use wh-ex-situ questions over wh-in-situ questions. The results from the children show that both age groups have the two question structures in their linguistic repertoire. However, they differ in their preferences in usage in the elicited production task: while the 5-year-olds preferred the wh-in-situ structure over the wh-ex-situ structure, the 4-year-olds showed a selective preference for the wh-in-situ structure in who-questions. These findings suggest a developmental change in wh-question preferences in Akan-learning children between 4 and 5 years of age with a so far unobserved u-shaped developmental pattern. In the elicited imitation task, all groups showed a strong tendency to maintain the structure of in-situ and ex-situ questions in repeating grammatical questions. When repairing ungrammatical ex-situ questions, structural changes to grammatical in-situ questions were hardly observed but the insertion of missing morphemes while keeping the ex-situ structure. Together, our findings provide only partial support for the Derivational Complexity Hypothesis.}, language = {en} } @phdthesis{Mueller2008, author = {M{\"u}ller, Melanie J. I.}, title = {Bidirectional transport by molecular motors}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-18715}, school = {Universit{\"a}t Potsdam}, year = {2008}, abstract = {In biological cells, the long-range intracellular traffic is powered by molecular motors which transport various cargos along microtubule filaments. The microtubules possess an intrinsic direction, having a 'plus' and a 'minus' end. Some molecular motors such as cytoplasmic dynein walk to the minus end, while others such as conventional kinesin walk to the plus end. Cells typically have an isopolar microtubule network. This is most pronounced in neuronal axons or fungal hyphae. In these long and thin tubular protrusions, the microtubules are arranged parallel to the tube axis with the minus ends pointing to the cell body and the plus ends pointing to the tip. In such a tubular compartment, transport by only one motor type leads to 'motor traffic jams'. Kinesin-driven cargos accumulate at the tip, while dynein-driven cargos accumulate near the cell body. We identify the relevant length scales and characterize the jamming behaviour in these tube geometries by using both Monte Carlo simulations and analytical calculations. A possible solution to this jamming problem is to transport cargos with a team of plus and a team of minus motors simultaneously, so that they can travel bidirectionally, as observed in cells. The presumably simplest mechanism for such bidirectional transport is provided by a 'tug-of-war' between the two motor teams which is governed by mechanical motor interactions only. We develop a stochastic tug-of-war model and study it with numerical and analytical calculations. We find a surprisingly complex cooperative motility behaviour. We compare our results to the available experimental data, which we reproduce qualitatively and quantitatively.}, language = {en} } @article{RoseGroegerHoelzle2021, author = {Rose, Robert and Groeger, Lars and H{\"o}lzle, Katharina}, title = {The Emergence of Shared Leadership in Innovation Labs}, series = {Frontiers in Psychology}, volume = {12}, journal = {Frontiers in Psychology}, publisher = {Frontiers in psychology}, address = {Lausanne, Schweiz}, issn = {1664-1078}, doi = {10.3389/fpsyg.2021.685167}, pages = {1 -- 13}, year = {2021}, abstract = {Implementing innovation laboratories to leverage intrapreneurship are an increasingly popular organizational practice. A typical feature in these creative environments are semi-autonomous teams in which multiple members collectively exert leadership influence, thereby challenging traditional command-and-control conceptions of leadership. An extensive body of research on the team-centric concept of shared leadership has recognized the potential for pluralized leadership structures in enhancing team effectiveness; however, little empirical work has been conducted in organizational contexts in which creativity is key. This study set out to explore antecedents of shared leadership and its influence on team creativity in an innovation lab. Building on extant shared leadership and innovation research, we propose antecedents customary to creative teamwork, that is, experimental culture, task reflexivity, and voice. Multisource data were collected from 104 team members and 49 evaluations of 29 coaches nested in 21 teams working in a prototypical innovation lab. We identify factors specific to creative teamwork that facilitate the emergence of shared leadership by providing room for experimentation, encouraging team members to speak up in the creative process, and cultivating a reflective application of entrepreneurial thinking. We provide specific exemplary activities for innovation lab teams to increase levels of shared leadership.}, language = {en} } @article{DordevicHoelzerRussoetal.2022, author = {Dordevic, Milos and H{\"o}lzer, Sonja and Russo, Augusta and Garc{\´i}a Alanis, Jos{\´e} Carlos and M{\"u}ller, Notger Germar}, title = {The Role of the Precuneus in Human Spatial Updating in a Real Environment Setting—A cTBS Study}, series = {Life}, volume = {12}, journal = {Life}, edition = {8}, publisher = {MDPI}, address = {Basel, Schweiz}, issn = {2075-1729}, doi = {10.3390/life12081239}, pages = {1 -- 13}, year = {2022}, abstract = {As we move through an environment, we update positions of our body relative to other objects, even when some objects temporarily or permanently leave our field of view—this ability is termed egocentric spatial updating and plays an important role in everyday life. Still, our knowledge about its representation in the brain is still scarce, with previous studies using virtual movements in virtual environments or patients with brain lesions suggesting that the precuneus might play an important role. However, whether this assumption is also true when healthy humans move in real environments where full body-based cues are available in addition to the visual cues typically used in many VR studies is unclear. Therefore, in this study we investigated the role of the precuneus in egocentric spatial updating in a real environment setting in 20 healthy young participants who underwent two conditions in a cross-over design: (a) stimulation, achieved through applying continuous theta-burst stimulation (cTBS) to inhibit the precuneus and (b) sham condition (activated coil turned upside down). In both conditions, participants had to walk back with blindfolded eyes to objects they had previously memorized while walking with open eyes. Simplified trials (without spatial updating) were used as control condition, to make sure the participants were not affected by factors such as walking blindfolded, vestibular or working memory deficits. A significant interaction was found, with participants performing better in the sham condition compared to real stimulation, showing smaller errors both in distance and angle. The results of our study reveal evidence of an important role of the precuneus in a real-environment egocentric spatial updating; studies on larger samples are necessary to confirm and further investigate this finding.}, language = {en} } @article{WestphalKalinowskiHoferichteretal.2022, author = {Westphal, Andrea and Kalinowski, Eva and Hoferichter, Clara Josepha and Vock, Miriam}, title = {K-12 teachers' stress and burnout during the COVID-19 pandemic: A systematic review}, series = {Frontiers in Psychology}, journal = {Frontiers in Psychology}, publisher = {Frontiers}, address = {Lausanne, Schweiz}, issn = {1664-1078}, doi = {10.3389/fpsyg.2022.920326}, pages = {1 -- 29}, year = {2022}, abstract = {We present the first systematic literature review on stress and burnout in K-12 teachers during the COVID-19 pandemic. Based on a systematic literature search, we identified 17 studies that included 9,874 K-12 teachers from around the world. These studies showed some indication that burnout did increase during the COVID-19 pandemic. There were, however, almost no differences in the levels of stress and burnout experienced by K-12 teachers compared to individuals employed in other occupational fields. School principals' leadership styles emerged as an organizational characteristic that is highly relevant for K-12 teachers' levels of stress and burnout. Individual teacher characteristics associated with burnout were K-12 teachers' personality, self-efficacy in online teaching, and perceived vulnerability to COVID-19. In order to reduce stress, there was an indication that stress-management training in combination with training in technology use for teaching may be superior to stress-management training alone. Future research needs to adopt more longitudinal designs and examine the interplay between individual and organizational characteristics in the development of teacher stress and burnout during the COVID-19 pandemic and beyond.}, language = {en} } @article{SpikesRodriguezSilvaBennettetal.2021, author = {Spikes, Montrai and Rodr{\´i}guez-Silva, Rodet and Bennett, Kerri-Ann and Br{\"a}ger, Stefan and Josaphat, James and Torres-Pineda, Patricia and Ernst, Anja and Havenstein, Katja and Schlupp, Ingo and Tiedemann, Ralph}, title = {A phylogeny of the genus Limia (Teleostei: Poeciliidae) suggests a single-lake radiation nested in a Caribbean-wide allopatric speciation scenario}, series = {BMC Research Notes}, volume = {14}, journal = {BMC Research Notes}, publisher = {BMC Research Notes / Biomed Central}, address = {London}, issn = {1756-0500}, doi = {10.1186/s13104-021-05843-x}, pages = {1 -- 8}, year = {2021}, abstract = {Objective The Caribbean is an important global biodiversity hotspot. Adaptive radiations there lead to many speciation events within a limited period and hence are particularly prominent biodiversity generators. A prime example are freshwater fish of the genus Limia, endemic to the Greater Antilles. Within Hispaniola, nine species have been described from a single isolated site, Lake Mirago{\^a}ne, pointing towards extraordinary sympatric speciation. This study examines the evolutionary history of the Limia species in Lake Mirago{\^a}ne, relative to their congeners throughout the Caribbean. Results For 12 Limia species, we obtained almost complete sequences of the mitochondrial cytochrome b gene, a well-established marker for lower-level taxonomic relationships. We included sequences of six further Limia species from GenBank (total N  = 18 species). Our phylogenies are in concordance with other published phylogenies of Limia. There is strong support that the species found in Lake Mirago{\^a}ne in Haiti are monophyletic, confirming a recent local radiation. Within Lake Mirago{\^a}ne, speciation is likely extremely recent, leading to incomplete lineage sorting in the mtDNA. Future studies using multiple unlinked genetic markers are needed to disentangle the relationships within the Lake Mirago{\^a}ne clade.}, language = {en} } @article{KruegerFoersterTrauthetal.2021, author = {Kr{\"u}ger, Johanna and Foerster, Verena Elisabeth and Trauth, Martin H. and Hofreiter, Michael and Tiedemann, Ralph}, title = {Exploring the Past Biosphere of Chew Bahir/Southern Ethiopia: Cross-Species Hybridization Capture of Ancient Sedimentary DNA from a Deep Drill Core}, series = {Frontiers in Earth Science}, journal = {Frontiers in Earth Science}, publisher = {Frontiers in Earth Science}, address = {Lausanne, Schweiz}, issn = {2296-6463}, doi = {10.3389/feart.2021.683010}, pages = {1 -- 20}, year = {2021}, abstract = {Eastern Africa has been a prime target for scientific drilling because it is rich in key paleoanthropological sites as well as in paleolakes, containing valuable paleoclimatic information on evolutionary time scales. The Hominin Sites and Paleolakes Drilling Project (HSPDP) explores these paleolakes with the aim of reconstructing environmental conditions around critical episodes of hominin evolution. Identification of biological taxa based on their sedimentary ancient DNA (sedaDNA) traces can contribute to understand past ecological and climatological conditions of the living environment of our ancestors. However, sedaDNA recovery from tropical environments is challenging because high temperatures, UV irradiation, and desiccation result in highly degraded DNA. Consequently, most of the DNA fragments in tropical sediments are too short for PCR amplification. We analyzed sedaDNA in the upper 70 m of the composite sediment core of the HSPDP drill site at Chew Bahir for eukaryotic remnants. We first tested shotgun high throughput sequencing which leads to metagenomes dominated by bacterial DNA of the deep biosphere, while only a small fraction was derived from eukaryotic, and thus probably ancient, DNA. Subsequently, we performed cross-species hybridization capture of sedaDNA to enrich ancient DNA (aDNA) from eukaryotic remnants for paleoenvironmental analysis, using established barcoding genes (cox1 and rbcL for animals and plants, respectively) from 199 species that may have had relatives in the past biosphere at Chew Bahir. Metagenomes yielded after hybridization capture are richer in reads with similarity to cox1 and rbcL in comparison to metagenomes without prior hybridization capture. Taxonomic assignments of the reads from these hybridization capture metagenomes also yielded larger fractions of the eukaryotic domain. For reads assigned to cox1, inferred wet periods were associated with high inferred relative abundances of putative limnic organisms (gastropods, green algae), while inferred dry periods showed increased relative abundances for insects. These findings indicate that cross-species hybridization capture can be an effective approach to enhance the information content of sedaDNA in order to explore biosphere changes associated with past environmental conditions, enabling such analyses even under tropical conditions.}, language = {en} } @inproceedings{BandaGallagher2010, author = {Banda, Gourinath and Gallagher, John P.}, title = {Constraint-based abstraction of a model checker for infinite state systems}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-41516}, year = {2010}, abstract = {Abstract interpretation-based model checking provides an approach to verifying properties of infinite-state systems. In practice, most previous work on abstract model checking is either restricted to verifying universal properties, or develops special techniques for temporal logics such as modal transition systems or other dual transition systems. By contrast we apply completely standard techniques for constructing abstract interpretations to the abstraction of a CTL semantic function, without restricting the kind of properties that can be verified. Furthermore we show that this leads directly to implementation of abstract model checking algorithms for abstract domains based on constraints, making use of an SMT solver.}, language = {en} } @article{Kohnen2011, author = {Kohnen, Saskia}, title = {Vernachl{\"a}ssigte Dyslexien}, series = {Spektrum Patholinguistik}, journal = {Spektrum Patholinguistik}, number = {4}, issn = {1869-3822}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-54226}, pages = {75 -- 81}, year = {2011}, language = {de} } @article{BethmannScheichBrechmann2011, author = {Bethmann, Anja and Scheich, Henning and Brechmann, Andr{\´e}}, title = {Produktion von Eigennamen}, series = {Spektrum Patholinguistik}, journal = {Spektrum Patholinguistik}, number = {4}, issn = {1869-3822}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-54246}, pages = {95 -- 116}, year = {2011}, language = {de} } @article{MeinuschNeumann2011, author = {Meinusch, Miriam and Neumann, Sandra}, title = {Systematisches Review zur Ermittlung wissenschaftlicher Evidenzen der Dysphagie bei LKGS-Fehlbildungen}, series = {Spektrum Patholinguistik}, journal = {Spektrum Patholinguistik}, number = {4}, issn = {1869-3822}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-54291}, pages = {149 -- 170}, year = {2011}, language = {de} } @article{PuritzSeidlFrank2011, author = {Puritz, Caroline and Seidl, Rainer Ottis and Frank, Ulrike}, title = {Die Auswirkungen des Lee Silverman Voice Treatments (LSVT) auf die kortikalen Repr{\"a}sentationen der Schluckmuskulatur bei Patienten mit Morbus Parkinson}, series = {Spektrum Patholinguistik}, journal = {Spektrum Patholinguistik}, number = {4}, issn = {1869-3822}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-54322}, pages = {189 -- 191}, year = {2011}, language = {de} } @article{EtzienMachlebLorenz2011, author = {Etzien, Maria and Machleb, Franziska and Lorenz, Antje}, title = {Semantische versus wortform-spezifische Merkmalsanalyse in der Behandlung von Wortabrufst{\"o}rungen bei Aphasie}, series = {Spektrum Patholinguistik}, journal = {Spektrum Patholinguistik}, number = {4}, issn = {1869-3822}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-54337}, pages = {193 -- 197}, year = {2011}, language = {de} } @article{Tagoe2011, author = {Tagoe, Tanja}, title = {Sprache und Emotion bei Kindern und Jugendlichen mit Williams-Beuren-Syndrom}, series = {Spektrum Patholinguistik}, journal = {Spektrum Patholinguistik}, number = {4}, issn = {1869-3822}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-54367}, pages = {217 -- 236}, year = {2011}, language = {de} } @article{WatermeyerHoehleKauschke2011, author = {Watermeyer, Melanie and H{\"o}hle, Barbara and Kauschke, Christina}, title = {Ausagieren von S{\"a}tzen versus Satz-Bild-Zuordnung}, series = {Spektrum Patholinguistik}, journal = {Spektrum Patholinguistik}, number = {4}, issn = {1869-3822}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-54374}, pages = {237 -- 246}, year = {2011}, language = {de} } @book{Peters2012, author = {Peters, Friedrich Ernst}, title = {Die dr{\"o}ge Trina : Geschichte einer "Poahr Dangoaß"}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-57245}, publisher = {Universit{\"a}t Potsdam}, year = {2012}, abstract = {"Die dr{\"o}ge Trina" erz{\"a}hlt eine von F. E. Peters in hochdeutscher Sprache ver{\"o}ffentlichte Geschichte aus der "Baasd{\"o}rper Kr{\"o}nk", der bedeutenden niederdeutschen Dorfchronik desselben Autors. Der Roman, 1946 erschienen, beschreibt, wie die Bauerntochter Trina D{\"u}hrsen, raffgierige Anbeterin des "Taler-Gottes", durch ihre Habgier das Leben ihres Bruders und ihres Ehemannes zerst{\"o}rt und versucht, ihren Neffen Wilhelm um sein Erbe zu bringen. Der Roman findet dennoch ein vers{\"o}hnliches Ende, als Trina inmitten der Inflation der Jahre 1922/1923 die Entwertung ihres Geldes und damit die Verg{\"a}nglichkeit irdischer G{\"u}ter erlebt, gleichzeitig aber menschliche Werte sch{\"a}tzen lernt . Der eigenwillige Untertitel "Geschichte einer Poahr Dangoaß" bezieht sich auf den Spitz- und Schimpfnamen Trinas, eine Verballhornung des franz{\"o}sischen Begriffs "poire d'angoisse" (f{\"u}r das Folterinstrument der Mundbirne), der ihr in Anspielung an ihren schlechten Charakter und die sch{\"o}nen, aber wenig schmackhaften Birnen ihres Hofes, die "Gurgelschn{\"u}rer", verliehen wurde. "Die dr{\"o}ge Trina" schildert mit freundlich-ironischer Empathie mentalit{\"a}tsgeschichtlich aufschlussreiche Verhaltensweisen, Sitten und Br{\"a}uche der norddeutschen Provinz im Zeitalter der Industrialisierung. Ber{\"u}hmtheit hat die Beschreibung eines Schweinewiegens erlangt. Die dr{\"o}ge Trina ist 1945 als Fortsetzungsroman unter dem Titel "Trina D{\"u}hrsen" in den Flensburger Nachrichten erschienen.}, language = {de} } @book{Peters2012, author = {Peters, Friedrich Ernst}, title = {Die schmale Br{\"u}cke}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-57258}, publisher = {Universit{\"a}t Potsdam}, year = {2012}, abstract = {"Die schmale Br{\"u}cke" ist eine Dreiecksgeschichte, die das Ringen zweier ungleicher M{\"a}nner um eine junge Frau schildert. Der fleißige und solide Mittelschulrektor Peter Hansen, der unter der Kinderlosigkeit und K{\"a}lte seiner Frau leidet, trifft nach dem Ersten Weltkrieg seinen "Jugendfeind", den redegewandten, bei den Damen hoch beliebten Werner Hagemann wieder, welcher im Zug die Lehrerin Ursula W{\"u}stenhagen kennengelernt hat, eine Kollegin Peter Hansens, in die dieser sich verliebt hat. In schw{\"u}ler Gespr{\"a}chsatmosph{\"a}re entwickelt sich eine Rivalit{\"a}t, die zunehmend bedrohliche Z{\"u}ge annimmt. Mordgedanken keimen auf. Schließlich fordert Peter Hansen, auf ein Gottesurteil hoffend, Werner Hagemann zu einem lebensgef{\"a}hrlichen Kr{\"a}ftemessen auf einer Br{\"u}cke auf. Die Erz{\"a}hlung ist das einzige Werk von F. E. Peters, das im Lehrermilieu spielt. Verwoben mit der spannungsreichen Dreiecksbeziehung sind Themen der Frauenemanzipation und modernen P{\"a}dagogik sowie zahlreiche literarische Reminiszenzen an den "Zauberberg" oder auch an Goethe und H{\"o}lderlin, insbesondere in der zentralen Frage der "Schicksalsw{\"u}rdigkeit". Der urspr{\"u}nglich von Peters gew{\"a}hlte Titel ("Der Schicksalsw{\"u}rdige") wurde auf Wunsch des Verlages in "Die schmale Br{\"u}cke" ge{\"a}ndert.}, language = {de} } @book{Peters2012, author = {Peters, Friedrich Ernst}, title = {Der heilsame Umweg}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-57261}, publisher = {Universit{\"a}t Potsdam}, year = {2012}, abstract = {„Der heilsame Umweg", 1939 mit dem Schleswig-Holsteinischen Literaturpreis ausgezeichnet, geh{\"o}rt zu der Gattung der deutsch-franz{\"o}sischen Verst{\"a}ndigungsromane, die in den dreißiger Jahren des 20. Jahrhunderts sehr erfolgreich waren. Der Roman beschreibt das Leben franz{\"o}sischer Kriegsgefangener in einem holsteinischen Dorf w{\"a}hrend des Ersten Weltkriegs und ist das fiktionale Pendant zu den Kriegserinnerungen von F.E. Peters, der selbst von 1914 bis 1920 Gefangener in Frankreich war und dort als Dolmetscher eingesetzt wurde. Im Mittelpunkt der Handlung steht die junge Elisabeth Torm{\"a}hlen, die sich von der weltfremden Sch{\"u}lerin eines M{\"a}dchenpensionats zu einer t{\"u}chtigen B{\"a}uerin und reifen Ehefrau entwickelt. W{\"a}hrend ihr Mann an der Front ist, entspinnt sich eine kurze harmlose Romanze zwischen ihr und dem franz{\"o}sischen Dolmetscher Gaston Marzais, die schnell beendet ist, als Elisabeth endg{\"u}ltig zu ihrem Mann findet und dieser sich nach Kriegsende von ihrer Treue {\"u}berzeugen kann. Das vielschichtige Werk beschreibt unter Verzicht auf die g{\"a}ngigen nationalen Stereotypen oder mittels deren Demontage Deutsche und Franzosen als in ihrer Unterschiedlichkeit sehr {\"a}hnlich. Durch zahlreiche Symmetrie-Effekte und konsequent durchgef{\"u}hrte Perspektivwechsel, die sowohl die deutsche als auch die franz{\"o}sische Sicht zu ber{\"u}cksichtigen suchen, wird das Gleiche im Fremden hervorgehoben. Gleicher Patriotismus und gleiche Opferbereitschaft auf beiden Seiten, aber auch gleiche Friedenssehns{\"u}chte und gleiches Leiden unter den Grausamkeiten des Krieges sowie gleiche fachliche Kompetenz - denn auch die gefangenen Franzosen sind erfahrene Bauern und bew{\"a}hren sich im t{\"a}glichen Zusammenleben. Fanatiker wie die verbitterte Soldatenwitwe Greta Harders oder der hasserf{\"u}llte Brandstifter Maurice Thaudi{\`e}re werden als lebensunt{\"u}chtig dargestellt und begehen Selbstmord. Den ideologischen Grundtenor des Werkes betonen zum Schluss noch einmal die Intellektuellen: Gaston Marzais und sein deutscher Freund, der Jurist Georg Schmitt, beide erf{\"u}llt von dem Wissen um und dem Respekt vor der Kultur des anderen. Gemeinsam wollen sie nach der deutschen Niederlage weitere deutsch-franz{\"o}sische Kriege verhindern und beschw{\"o}ren die pazifistische Vision eines Europas der Toleranz und der Aufkl{\"a}rung. „Der heilsame Umweg" ist dar{\"u}ber hinaus eine Hymne an b{\"a}uerliche Kultur und famili{\"a}re Werte. So bewundert Marzais Interieur und Kleidung der alten B{\"a}uerin Abel Schierholdt. Auch ein traditionelles norddeutsches Begr{\"a}bnisritual wird detailliert beschrieben. Frankreichs Landleben ist pr{\"a}sent durch nostalgische Evozierungen der Gefangenen und deutliche Ankl{\"a}nge an den am Anfang des letzten Jahrhunderts sehr beliebten Roman von Henry Bordeaux „Les Roquevillard" (1906), den F.E.Peters w{\"a}hrend seiner Kriegsgefangenschaft {\"u}bersetzt hat. Schließlich reflektiert der Roman Macht und Ohnmacht von Sprache sowie die autobiographische Dimension literarischer Produktions- und Rezeptionsprozesse. Seine Heldin - und mit ihr der Leser - erkennt, "dass Dichtung nur echt ist als erlittenes Leben und dass sie nur aus der Erfahrung des Leides verstanden wird."}, language = {de} } @article{Peters2012, author = {Peters, Friedrich Ernst}, title = {"Ulenspegel un Jan Dood"}, series = {Digitale Edition : Friedrich Peters}, journal = {Digitale Edition : Friedrich Peters}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-58086}, year = {2012}, abstract = {Charakterisierung des literarischen Schaffens von Moritz Jahn. Seine Bedeutung f{\"u}r das Plattdeutsche. F. E. Peters beschreibt, Moritz Jahn humorvoll folgend, "polare Spannungen" in Niederdeutschland: "Es gibt Niederdeutsche, die ihrem Lande nie so ganz trauen, die daheim in einer immerw{\"a}hrenden leisen Unruhe hinleben und die aufatmen, wenn sie in gebirgiger Gegend das nackte Gestein unter ihren F{\"u}ßen f{\"u}hlen. Dann wird klar, was sie sich bis dahin m{\"u}hsam verhehlt haben: dass sie n{\"a}mlich in einem geheimen Winkel ihrer Seele glauben, ihr Land sei vom Meere untersp{\"u}lt, k{\"o}nne an besonders d{\"u}nnen Stellen durchbrechen, vom festen Kern der Erde losgerissen werden und in die Nebel der Unendlichkeit hinaustreiben. Auf felsigem Grund werden sie dann die neue und wohltuende Sicherheit mit großer Freude so lange genießen, bis das unwiderstehliche Heimweh sie zur{\"u}cktreibt in die Unsicherheit."}, language = {de} } @article{Peters2012, author = {Peters, Friedrich Ernst}, title = {Meissenheim}, series = {Digitale Edition : Friedrich Peters}, journal = {Digitale Edition : Friedrich Peters}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-57979}, year = {2012}, abstract = {Beschreibung einer Reise durch das Elsass verflochten mit Zitaten aus F. H{\"o}lderlins Gedicht „Der Rhein" (1801) und Entdeckung des Friederike-Brion-Grabes in Meißenheim. Peters entzaubert den Friederike-Mythos mit einer empathisch-kritischen Frage, die literarische {\"U}berh{\"o}hung und Lebenswirklichkeit kontrastiert: „Dem M{\"a}dchen aus Sesenheim geschah Leid von dem Halbgott. Leid war der Preis f{\"u}r das Licht der Unsterblichkeit,… War der Preis zu hoch?"}, language = {de} } @article{Peters2012, author = {Peters, Friedrich Ernst}, title = {Timm Kr{\"o}ger}, series = {Digitale Edition : Friedrich Peters}, journal = {Digitale Edition : Friedrich Peters}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-57984}, year = {2012}, abstract = {Der norddeutsche Schriftsteller Timm Kr{\"o}ger ist in Haale (Kreis Rendsburg-Eckernf{\"o}rde) geboren, einem Dorf, das in n{\"a}chster N{\"a}he von Luhnstedt, dem Heimatdorf von F.E. Peters, liegt. Peters und Kr{\"o}ger sind sich nie pers{\"o}nlich begegnet, hatten aber gemeinsame Bekannte. „Timm Kr{\"o}ger - der Dichter unserer Heimat" stammt aus dem Nachlass von F.E. Peters, der ein Bewunderer der Kunst Timm Kr{\"o}gers war und den „besonderen lyrischen Schimmer" seiner Erz{\"a}hlkunst geliebt hat. Die Rede ist anl{\"a}sslich des 110. Geburtstages von Timm Kr{\"o}ger entstanden. Peters nimmt das Jubil{\"a}um zum Anlass, anhand von Zitaten aus Kr{\"o}gers Vorwort zu einer Gesamtausgabe seiner Werke die Gattung Heimatdichtung kritisch zu beleuchten und zu unterscheiden zwischen einer ideologisch gef{\"a}rbten schablonenhaften Heimatdichtung und einer Dichtung, welche die Landschaften der Heimat in den Mittelpunkt stellt, das Provinzielle jedoch {\"u}berwindet: „Es sei zugegeben, dass von sogenannten Heimatdichtern viel plattes Zeug geliefert wird. Darum spreche ich heute von dem Dichter unserer Heimat, nicht von dem Heimatdichter Timm Kr{\"o}ger."}, language = {de} } @article{Peters2012, author = {Peters, Friedrich Ernst}, title = {S{\"a}chsische Ubiquit{\"a}t}, series = {Digitale Edition : Friedrich Peters}, journal = {Digitale Edition : Friedrich Peters}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-57994}, year = {2012}, abstract = {Humorvolle Schilderung einer Alltagsszene im Dresdener Museum vor Rembrandts Bild „Ganymed in den F{\"a}ngen des Adlers" mit geistreichem Br{\"u}ckenschlag zu Langbehns „Rembrandt als Erzieher" (1890).}, language = {de} } @article{Peters2012, author = {Peters, Friedrich Ernst}, title = {Unterschiedliche Moden}, series = {Digitale Edition : Friedrich Peters}, journal = {Digitale Edition : Friedrich Peters}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-58002}, year = {2012}, abstract = {Anekdoten und Beobachtungen zu Denk- und Verhaltensweisen in der norddeutschen Provinz mit sensibler Charakterisierung des l{\"a}ndlichen Lebensrhythmus. Die vierte und die f{\"u}nfte Geschichte findet man auch in der "Baasd{\"o}rper Kr{\"o}nk". „Unterschiedliche Moden" ist eine Hommage an Timm Kr{\"o}ger.}, language = {de} } @article{Rarog2013, author = {Rarog, Alexey}, title = {Strafrechtliche Verantwortlichkeit von Amtstr{\"a}gern im deutschen und russischen Recht}, series = {Schriften zum deutschen und russischen Strafrecht}, journal = {Schriften zum deutschen und russischen Strafrecht}, number = {3}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {2191-0898}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-67452}, pages = {13 -- 16}, year = {2013}, language = {de} } @article{Чучаев2013, author = {Чучаев, А. И.}, title = {Ответственность за контрабанду}, series = {Schriften zum deutschen und russischen Strafrecht}, journal = {Schriften zum deutschen und russischen Strafrecht}, number = {3}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-67474}, pages = {17 -- 20}, year = {2013}, language = {ru} }