@book{SchmidtUlrichBuechneretal.2024,
  author    = {Schmidt, Thorsten Ingo and Ulrich, Peter and B{\"u}chner, Christiane and Franzke, Jochen and Jann, Werner and Bauer, Hartmut and Wagner, Dieter and Br{\"u}ning, Christoph and Bickenbach, Christian and Kuhlmann, Sabine and Peters, Niklas and Reichard, Christoph and Tessmann, Jens and Maaß, Christian and Kern, Kristine and Kochsk{\"a}mper, Elisa and Gailing, Ludger and Krzymuski, Marcin},
  title     = {Kommunalwissenschaften an der Universit{\"a}t Potsdam},
  series = {KWI-Schriften},
  journal   = {KWI-Schriften},
  number    = {15},
  editor    = {Schmidt, Thorsten Ingo and Bickenbach, Christian and Gronewold, Ulfert and Kuhlmann, Sabine and Ulrich, Peter},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-581-1},
  issn      = {1867-951X},
  doi       = {10.25932/publishup-63618},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-636180},
  publisher      = {Universit{\"a}t Potsdam},
  pages     = {124},
  year      = {2024},
  abstract  = {Zum dreißigj{\"a}hrigen Bestehen des Kommunalwissenschaftlichen Instituts an der Universit{\"a}t Potsdam vereint dieser Jubil{\"a}umsband kurze Aufs{\"a}tze von ehemaligen und aktuellen Vorstandsmitgliedern, von Ehrenmitgliedern des Vorstands, langj{\"a}hrigen wissenschaftlichen Mitarbeitern des Instituts und aktuellen wissenschaftlichen Kooperationspartnern. Die insgesamt zw{\"o}lf Beitr{\"a}ge befassen sich mit den Kommunalwissenschaften und der Geschichte des Kommunalwissenschaftlichen Instituts, mit aktuellen kommunalwissenschaftlichen Fragestellungen und wissenschaftlichen Kooperationen des KWI. Der vom KWI-Vorstand herausgegebene Band soll einen breiten Blick auf 30 Jahre Kommunalwissenschaften in Brandenburg und an der Universit{\"a}t Potsdam werfen und einen Ausblick auf zuk{\"u}nftige kommunalwissenschaftliche Forschung geben.},
  language  = {de}
}
@article{Maass2024,
  author    = {Maaß, Christian},
  title     = {Brandenburg, (k)ein Land der Reformen?},
  series = {Kommunalwissenschaften an der Universit{\"a}t Potsdam (KWI-Schriften ; 15)},
  journal   = {Kommunalwissenschaften an der Universit{\"a}t Potsdam (KWI-Schriften ; 15)},
  number    = {15},
  editor    = {Schmidt, Thorsten Ingo and Bickenbach, Christian and Gronewold, Ulfert and Kuhlmann, Sabine and Ulrich, Peter},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-581-1},
  issn      = {1867-951X},
  doi       = {10.25932/publishup-64787},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-647878},
  pages     = {87 -- 98},
  year      = {2024},
  language  = {de}
}
@article{KernKochskaemper2024,
  author    = {Kern, Kristine and Kochsk{\"a}mper, Elisa},
  title     = {Wege zur urbanen Transformation},
  series = {Kommunalwissenschaften an der Universit{\"a}t Potsdam (KWI-Schriften ; 15)},
  journal   = {Kommunalwissenschaften an der Universit{\"a}t Potsdam (KWI-Schriften ; 15)},
  number    = {15},
  editor    = {Schmidt, Thorsten Ingo and Bickenbach, Christian and Gronewold, Ulfert and Kuhlmann, Sabine and Ulrich, Peter},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-581-1},
  issn      = {1867-951X},
  doi       = {10.25932/publishup-64788},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-647882},
  pages     = {101 -- 109},
  year      = {2024},
  language  = {de}
}
@article{Gailing2024,
  author    = {Gailing, Ludger},
  title     = {Regionalplanung - und die Kommunalwissenschaften},
  series = {Kommunalwissenschaften an der Universit{\"a}t Potsdam (KWI-Schriften ; 15)},
  journal   = {Kommunalwissenschaften an der Universit{\"a}t Potsdam (KWI-Schriften ; 15)},
  number    = {15},
  editor    = {Schmidt, Thorsten Ingo and Bickenbach, Christian and Gronewold, Ulfert and Kuhlmann, Sabine and Ulrich, Peter},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-581-1},
  issn      = {1867-951X},
  doi       = {10.25932/publishup-64789},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-647899},
  pages     = {111 -- 120},
  year      = {2024},
  language  = {de}
}
@article{Tessmann2024,
  author    = {Tessmann, Jens},
  title     = {Organisationsvarianten kommunaler Selbstverwaltung in Deutschland},
  series = {Kommunalwissenschaften an der Universit{\"a}t Potsdam (KWI-Schriften ; 15)},
  journal   = {Kommunalwissenschaften an der Universit{\"a}t Potsdam (KWI-Schriften ; 15)},
  number    = {15},
  editor    = {Schmidt, Thorsten Ingo and Bickenbach, Christian and Gronewold, Ulfert and Kuhlmann, Sabine and Ulrich, Peter},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-581-1},
  issn      = {1867-951X},
  doi       = {10.25932/publishup-64786},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-647869},
  pages     = {79 -- 85},
  year      = {2024},
  language  = {de}
}
@article{Krzymuski2024,
  author    = {Krzymuski, Marcin},
  title     = {Ph{\"a}nomen des Kollisionsrechts im Verwaltungsrecht?},
  series = {Kommunalwissenschaften an der Universit{\"a}t Potsdam (KWI-Schriften ; 15)},
  journal   = {Kommunalwissenschaften an der Universit{\"a}t Potsdam (KWI-Schriften ; 15)},
  number    = {15},
  editor    = {Schmidt, Thorsten Ingo and Bickenbach, Christian and Gronewold, Ulfert and Kuhlmann, Sabine and Ulrich, Peter},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-581-1},
  issn      = {1867-951X},
  doi       = {10.25932/publishup-64791},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-647912},
  pages     = {121 -- 124},
  year      = {2024},
  language  = {de}
}
@misc{WernerCiceroneKliegletal.1984,
  author    = {Werner, John S. and Cicerone, Carola M. and Kliegl, Reinhold and DellaRosa, Denise},
  title     = {Spectral efficiency of blackness induction},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-16897},
  year      = {1984},
  abstract  = {The spectral efficiency of blackness induction was measured in three normal trichromatic observers and in one deuteranomalous observer. The psychophysical task was to adjust the radiance of a monochromatic 60-120′ annulus until a 45′ central broadband field just turned black and its contour became indiscriminable from a dark surrounding gap that separated it from the annulus. The reciprocal of the radiance required to induce blackness with annulus wavelengths between 420 and 680 nm was used to define a spectral-efficiency function for the blackness component of the achromatic process. For each observer, the shape of this blackness-sensitivity function agreed with the spectral-efficiency function based on heterochromatic flicker photometry when measured with the same 60-120′ annulus. Both of these functions matched the Commission Internationale de l'Eclairage Vλ function except at short wavelengths. Ancillary measurements showed that the latter difference in sensitivity can be ascribed to nonuniformities of preretinal absorption, since the annular field excluded the central 60′ of the fovea. Thus our evidence indicates that, at least to a good first approximation, induced blackness is inversely related to the spectral-luminosity function. These findings are consistent with a model that separates the achromatic and the chromatic pathways.},
  language  = {en}
}
@phdthesis{Ketzer2024,
  author    = {Ketzer, Laura},
  title     = {The impact of stellar activity evolution on atmospheric mass loss of young exoplanets},
  doi       = {10.25932/publishup-62681},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-626819},
  school      = {Universit{\"a}t Potsdam},
  pages     = {x, 208},
  year      = {2024},
  abstract  = {The increasing number of known exoplanets raises questions about their demographics and the mechanisms that shape planets into how we observe them today. Young planets in close-in orbits are exposed to harsh environments due to the host star being magnetically highly active, which results in high X-ray and extreme UV fluxes impinging on the planet. Prolonged exposure to this intense photoionizing radiation can cause planetary atmospheres to heat up, expand and escape into space via a hydrodynamic escape process known as photoevaporation. For super-Earth and sub-Neptune-type planets, this can even lead to the complete erosion of their primordial gaseous atmospheres. A factor of interest for this particular mass-loss process is the activity evolution of the host star. Stellar rotation, which drives the dynamo and with it the magnetic activity of a star, changes significantly over the stellar lifetime. This strongly affects the amount of high-energy radiation received by a planet as stars age. At a young age, planets still host warm and extended envelopes, making them particularly susceptible to atmospheric evaporation. Especially in the first gigayear, when X-ray and UV levels can be 100 - 10,000 times higher than for the present-day sun, the characteristics of the host star and the detailed evolution of its high-energy emission are of importance. In this thesis, I study the impact of stellar activity evolution on the high-energy-induced atmospheric mass loss of young exoplanets. The PLATYPOS code was developed as part of this thesis to calculate photoevaporative mass-loss rates over time. The code, which couples parameterized planetary mass-radius relations with an analytical hydrodynamic escape model, was used, together with Chandra and eROSITA X-ray observations, to investigate the future mass loss of the two young multiplanet systems V1298 Tau and K2-198. Further, in a numerical ensemble study, the effect of a realistic spread of activity tracks on the small-planet radius gap was investigated for the first time. The works in this thesis show that for individual systems, in particular if planetary masses are unconstrained, the difference between a young host star following a low-activity track vs. a high-activity one can have major implications: the exact shape of the activity evolution can determine whether a planet can hold on to some of its atmosphere, or completely loses its envelope, leaving only the bare rocky core behind. For an ensemble of simulated planets, an observationally-motivated distribution of activity tracks does not substantially change the final radius distribution at ages of several gigayears. My simulations indicate that the overall shape and slope of the resulting small-planet radius gap is not significantly affected by the spread in stellar activity tracks. However, it can account for a certain scattering or fuzziness observed in and around the radius gap of the observed exoplanet population.},
  language  = {en}
}
@article{DeekenReichertZechetal.2022,
  author    = {Deeken, Friederike and Reichert, Markus and Zech, Hilmar and Wenzel, Julia and Wedemeyer, Friederike and Aguilera, Alvaro and Aslan, Acelya and Bach, Patrick and Bahr, Nadja Samia and Ebrahimi, Claudia and Fischbach, Pascale Christine and Ganz, Marvin and Garbusow, Maria and Großkopf, Charlotte M. and Heigert, Marie and Hentschel, Angela and Karl, Damian and Pelz, Patricia and Pinger, Mathieu and Riemerschmid, Carlotta and Rosenthal, Annika and Steffen, Johannes and Strehle, Jens and Weiss,, Franziska and Wieder, Gesine and Wieland, Alfred and Zaiser, Judith and Zimmermann, Sina and Walter, Henrik and Lenz, Bernd and Deserno, Lorenz and Smolka, Michael N. and Liu, Shuyan and Ebner-Priemer, Ulrich Walter and Heinz, Andreas and Rapp, Michael A.},
  title     = {Patterns of Alcohol Consumption Among Individuals With Alcohol Use Disorder During the COVID-19 Pandemic and Lockdowns in Germany},
  series = {JAMA Network Open},
  volume    = {5},
  journal   = {JAMA Network Open},
  edition   = {8},
  publisher = {JAMA Network / American Medical Association},
  address   = {Chicago, Illinois, USA},
  issn      = {2574-3805},
  doi       = {10.1001/jamanetworkopen.2022.24641},
  pages     = {1 -- 11},
  year      = {2022},
  abstract  = {Importance Alcohol consumption (AC) leads to death and disability worldwide. Ongoing discussions on potential negative effects of the COVID-19 pandemic on AC need to be informed by real-world evidence. Objective To examine whether lockdown measures are associated with AC and consumption-related temporal and psychological within-person mechanisms. Design, Setting, and Participants This quantitative, intensive, longitudinal cohort study recruited 1743 participants from 3 sites from February 20, 2020, to February 28, 2021. Data were provided before and within the second lockdown of the COVID-19 pandemic in Germany: before lockdown (October 2 to November 1, 2020); light lockdown (November 2 to December 15, 2020); and hard lockdown (December 16, 2020, to February 28, 2021). Main Outcomes and Measures Daily ratings of AC (main outcome) captured during 3 lockdown phases (main variable) and temporal (weekends and holidays) and psychological (social isolation and drinking intention) correlates. Results Of the 1743 screened participants, 189 (119 [63.0\%] male; median [IQR] age, 37 [27.5-52.0] years) with at least 2 alcohol use disorder (AUD) criteria according to the Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition) yet without the need for medically supervised alcohol withdrawal were included. These individuals provided 14 694 smartphone ratings from October 2020 through February 2021. Multilevel modeling revealed significantly higher AC (grams of alcohol per day) on weekend days vs weekdays (β = 11.39; 95\% CI, 10.00-12.77; P < .001). Alcohol consumption was above the overall average on Christmas (β = 26.82; 95\% CI, 21.87-31.77; P < .001) and New Year's Eve (β = 66.88; 95\% CI, 59.22-74.54; P < .001). During the hard lockdown, perceived social isolation was significantly higher (β = 0.12; 95\% CI, 0.06-0.15; P < .001), but AC was significantly lower (β = -5.45; 95\% CI, -8.00 to -2.90; P = .001). Independent of lockdown, intention to drink less alcohol was associated with lower AC (β = -11.10; 95\% CI, -13.63 to -8.58; P < .001). Notably, differences in AC between weekend and weekdays decreased both during the hard lockdown (β = -6.14; 95\% CI, -9.96 to -2.31; P = .002) and in participants with severe AUD (β = -6.26; 95\% CI, -10.18 to -2.34; P = .002). Conclusions and Relevance This 5-month cohort study found no immediate negative associations of lockdown measures with overall AC. Rather, weekend-weekday and holiday AC patterns exceeded lockdown effects. Differences in AC between weekend days and weekdays evinced that weekend drinking cycles decreased as a function of AUD severity and lockdown measures, indicating a potential mechanism of losing and regaining control. This finding suggests that temporal patterns and drinking intention constitute promising targets for prevention and intervention, even in high-risk individuals.},
  language  = {en}
}
@article{BrahmsHeinzelRappetal.2022,
  author    = {Brahms, Markus and Heinzel, Stephan and Rapp, Michael A. and M{\"u}ckstein, Marie and Hortob{\´a}gyi, Tibor and Stelzel, Christine and Granacher, Urs},
  title     = {The acute effects of mental fatigue on balance performance in healthy young and older adults - A systematic review and meta-analysis},
  series = {Acta Psychologica},
  volume    = {225},
  journal   = {Acta Psychologica},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1873-6297},
  doi       = {10.1016/j.actpsy.2022.103540},
  pages     = {1 -- 13},
  year      = {2022},
  abstract  = {Cognitive resources contribute to balance control. There is evidence that mental fatigue reduces cognitive resources and impairs balance performance, particularly in older adults and when balance tasks are complex, for example when trying to walk or stand while concurrently performing a secondary cognitive task. We conducted a systematic literature search in PubMed (MEDLINE), Web of Science and Google Scholar to identify eligible studies and performed a random effects meta-analysis to quantify the effects of experimentally induced mental fatigue on balance performance in healthy adults. Subgroup analyses were computed for age (healthy young vs. healthy older adults) and balance task complexity (balance tasks with high complexity vs. balance tasks with low complexity) to examine the moderating effects of these factors on fatigue-mediated balance performance. We identified 7 eligible studies with 9 study groups and 206 participants. Analysis revealed that performing a prolonged cognitive task had a small but significant effect (SMDwm = -0.38) on subsequent balance performance in healthy young and older adults. However, age- and task-related differences in balance responses to fatigue could not be confirmed statistically. Overall, aggregation of the available literature indicates that mental fatigue generally reduces balance in healthy adults. However, interactions between cognitive resource reduction, aging and balance task complexity remain elusive.},
  language  = {en}
}
@article{CorbettSiegelThulin2024,
  author    = {Corbett, Tim and Siegel, Bj{\"o}rn and Thulin, Mirjam},
  title     = {Towards Pluricultural and Connected Histories},
  series = {PaRDeS},
  journal   = {PaRDeS},
  number    = {29},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-574-3},
  issn      = {1614-6492},
  doi       = {10.25932/publishup-64598},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-645988},
  pages     = {15 -- 27},
  year      = {2024},
  language  = {en}
}
@article{Hoedl2024,
  author    = {H{\"o}dl, Klaus},
  title     = {Blurring the Boundaries of Jewishness},
  series = {PaRDeS},
  journal   = {PaRDeS},
  number    = {29},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-574-3},
  issn      = {1614-6492},
  doi       = {10.25932/publishup-64600},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-646009},
  pages     = {39 -- 50},
  year      = {2024},
  abstract  = {In this essay I argue that while research in Jewish studies over the last several decades has done much to erode the historical narrative of Jewish/non-Jewish separation and detachment, it has also raised various questions pertaining to the outcome of Jewish/non-Jewish interactions and coexistence as well as the contours of Jewish difference. I contend that employing the concepts of conviviality, ethnic/religious/national indifference, and similarity will greatly facilitate answering these questions.},
  language  = {en}
}
@article{Csaky2024,
  author    = {Cs{\´a}ky, Moritz},
  title     = {Habsburg Central Europe},
  series = {PaRDeS},
  journal   = {PaRDeS},
  number    = {29},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-574-3},
  issn      = {1614-6492},
  doi       = {10.25932/publishup-64599},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-645995},
  pages     = {31 -- 37},
  year      = {2024},
  abstract  = {Central Europe is characterized by linguistic and cultural density as well as by endogenous and exogenous cultural influences. These constellations were especially visible in the former Habsburg Empire, where they influenced the formation of individual and collective identities. This led not only to continual crises and conflicts, but also to an equally enormous creative potential as became apparent in the culture of the fin-de-si{\`e}cle.},
  language  = {en}
}
@article{YeZhangWarbyetal.2022,
  author    = {Ye, Fangyuan and Zhang, Shuo and Warby, Jonathan and Wu, Jiawei and Gutierrez-Partida, Emilio and Lang, Felix and Shah, Sahil and Saglamkaya, Elifnaz and Sun, Bowen and Zu, Fengshuo and Shoai, Safa and Wang, Haifeng and Stiller, Burkhard and Neher, Dieter and Zhu, Wei-Hong and Stolterfoht, Martin and Wu, Yongzhen},
  title     = {Overcoming C₆₀-induced interfacial recombination in inverted perovskite solar cells by electron-transporting carborane},
  series = {Nature Communications},
  volume    = {13},
  journal   = {Nature Communications},
  number    = {1},
  publisher = {Springer Nature},
  address   = {London},
  issn      = {2041-1723},
  doi       = {10.1038/s41467-022-34203-x},
  pages     = {12},
  year      = {2022},
  abstract  = {Inverted perovskite solar cells still suffer from significant non-radiative recombination losses at the perovskite surface and across the perovskite/C₆₀ interface, limiting the future development of perovskite-based single- and multi-junction photovoltaics. Therefore, more effective inter- or transport layers are urgently required. To tackle these recombination losses, we introduce ortho-carborane as an interlayer material that has a spherical molecular structure and a three-dimensional aromaticity. Based on a variety of experimental techniques, we show that ortho-carborane decorated with phenylamino groups effectively passivates the perovskite surface and essentially eliminates the non-radiative recombination loss across the perovskite/C₆₀ interface with high thermal stability. We further demonstrate the potential of carborane as an electron transport material, facilitating electron extraction while blocking holes from the interface. The resulting inverted perovskite solar cells deliver a power conversion efficiency of over 23\% with a low non-radiative voltage loss of 110 mV, and retain >97\% of the initial efficiency after 400 h of maximum power point tracking. Overall, the designed carborane based interlayer simultaneously enables passivation, electron-transport and hole-blocking and paves the way toward more efficient and stable perovskite solar cells.},
  language  = {en}
}
@article{HeroldLabottGraessleretal.2022,
  author    = {Herold, Fabian and Labott, Berit K. and Gr{\"a}ssler, Bernhard and Halfpaap, Nicole and Langhans, Corinna and M{\"u}ller, Patrick and Ammar, Achraf and Dordevic, Milos and H{\"o}kelmann, Anita and M{\"u}ller, Notger Germar},
  title     = {A Link between Handgrip Strength and Executive Functioning: A Cross-Sectional Study in Older Adults with Mild Cognitive Impairment and Healthy Controls},
  series = {Healthcare : open access journal},
  volume    = {10},
  journal   = {Healthcare : open access journal},
  edition   = {2},
  publisher = {MDPI},
  address   = {Basel, Schweiz},
  issn      = {2227-9032},
  doi       = {10.3390/healthcare10020230},
  pages     = {1 -- 14},
  year      = {2022},
  abstract  = {Older adults with amnestic mild cognitive impairment (aMCI) who in addition to their memory deficits also suffer from frontal-executive dysfunctions have a higher risk of developing dementia later in their lives than older adults with aMCI without executive deficits and older adults with non-amnestic MCI (naMCI). Handgrip strength (HGS) is also correlated with the risk of cognitive decline in the elderly. Hence, the current study aimed to investigate the associations between HGS and executive functioning in individuals with aMCI, naMCI and healthy controls. Older, right-handed adults with amnestic MCI (aMCI), non-amnestic MCI (naMCI), and healthy controls (HC) conducted a handgrip strength measurement via a handheld dynamometer. Executive functions were assessed with the Trail Making Test (TMT A\&B). Normalized handgrip strength (nHGS, normalized to Body Mass Index (BMI)) was calculated and its associations with executive functions (operationalized through z-scores of TMT B/A ratio) were investigated through partial correlation analyses (i.e., accounting for age, sex, and severity of depressive symptoms). A positive and low-to-moderate correlation between right nHGS (rp (22) = 0.364; p = 0.063) and left nHGS (rp (22) = 0.420; p = 0.037) and executive functioning in older adults with aMCI but not in naMCI or HC was observed. Our results suggest that higher levels of nHGS are linked to better executive functioning in aMCI but not naMCI and HC. This relationship is perhaps driven by alterations in the integrity of the hippocampal-prefrontal network occurring in older adults with aMCI. Further research is needed to provide empirical evidence for this assumption.},
  language  = {en}
}
@phdthesis{Sieg2018,
  author    = {Sieg, Tobias},
  title     = {Reliability of flood damage estimations across spatial scales},
  doi       = {10.25932/publishup-42616},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-426161},
  school      = {Universit{\"a}t Potsdam},
  pages     = {XIII, 115},
  year      = {2018},
  abstract  = {Extreme Naturereignisse sind ein integraler Bestandteil der Natur der Erde. Sie werden erst dann zu Gefahren f{\"u}r die Gesellschaft, wenn sie diesen Ereignissen ausgesetzt ist. Dann allerdings k{\"o}nnen Naturgefahren verheerende Folgen f{\"u}r die Gesellschaft haben. Besonders hydro-meteorologische Gefahren wie zum Beispiel Flusshochwasser, Starkregenereignisse, Winterst{\"u}rme, Orkane oder Tornados haben ein hohes Schadenspotential und treten rund um den Globus auf. Einhergehend mit einer immer w{\"a}rmer werdenden Welt, werden auch Extremwetterereignisse, welche potentiell Naturgefahren ausl{\"o}sen k{\"o}nnen, immer wahrscheinlicher. Allerdings tr{\"a}gt nicht nur eine sich ver{\"a}ndernde Umwelt zur Erh{\"o}hung des Risikos von Naturgefahren bei, sondern auch eine sich ver{\"a}ndernde Gesellschaft. Daher ist ein angemessenes Risikomanagement erforderlich um die Gesellschaft auf jeder r{\"a}umlichen Ebene an diese Ver{\"a}nderungen anzupassen. Ein essentieller Bestandteil dieses Managements ist die Absch{\"a}tzung der {\"o}konomischen Auswirkungen der Naturgefahren. Bisher allerdings fehlen verl{\"a}ssliche Methoden um die Auswirkungen von hydro-meteorologischen Gefahren abzusch{\"a}tzen. Ein Hauptbestandteil dieser Arbeit ist daher die Entwicklung und Anwendung einer neuen Methode, welche die Verl{\"a}sslichkeit der Schadenssch{\"a}tzung verbessert. Die Methode wurde beispielhaft zur Sch{\"a}tzung der {\"o}konomischen Auswirkungen eines Flusshochwassers auf einzelne Unternehmen bis hin zu den Auswirkungen auf das gesamte Wirtschaftssystem Deutschlands erfolgreich angewendet. Bestehende Methoden geben meist wenig Information {\"u}ber die Verl{\"a}sslichkeit ihrer Sch{\"a}tzungen. Da diese Informationen Entscheidungen zur Anpassung an das Risiko erleichtern, wird die Verl{\"a}sslichkeit der Schadenssch{\"a}tzungen mit der neuen Methode dargestellt. Die Verl{\"a}sslichkeit bezieht sich dabei nicht nur auf die Schadenssch{\"a}tzung selber, sondern auch auf die Annahmen, die {\"u}ber betroffene Geb{\"a}ude gemacht werden. Nach diesem Prinzip kann auch die Verl{\"a}sslichkeit von Annahmen {\"u}ber die Zukunft dargestellt werden, dies ist ein wesentlicher Aspekt f{\"u}r Prognosen. Die Darstellung der Verl{\"a}sslichkeit und die erfolgreiche Anwendung zeigt das Potential der Methode zur Verwendung von Analysen f{\"u}r gegenw{\"a}rtige und zuk{\"u}nftige hydro-meteorologische Gefahren.},
  language  = {en}
}
@article{RoeslerGasparatosHermanussenetal.2022,
  author    = {R{\"o}sler, Antonia and Gasparatos, Nikolaos and Hermanussen, Michael and Scheffler, Christiane},
  title     = {Practicability and user-friendliness of height measurements by proof of concept APP using Augmented Reality, in 22 healthy children},
  series = {Human biology and public health},
  volume    = {2022},
  journal   = {Human biology and public health},
  number    = {2},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  issn      = {2748-9957},
  doi       = {10.52905/hbph2022.2.48},
  pages     = {9},
  year      = {2022},
  abstract  = {Background: Child growth is a dynamic process. When measured at short intervals, children's growth shows characteristic patterns that can be of great importance for clinical purposes. Objective: To study whether measuring height on a daily basis using an APP is practicable and user-friendly. Methods: Recruitment took place via Snowball Sampling. Thirteen out of 14 contacted families signed up for a study period of 12 weeks with altogether 22 healthy children aged 3 to 13 years (response rate 93\%). The study started with a visit to the family home for the setup of the measurement site, conventional height measuring and initial training of the new measurement process. Follow-up appointments were made at four, eight and 12 weeks. The children's height was measured at daily intervals at their family homes over a period of three months. Results: The parents altogether recorded 1704 height measurements and meticulously documented practicability and problems when using the device. A 93\% response rate in recruitment was achieved by maintaining a high motivation within the families. Contact with the principal investigator was permanently available, including open communication, personal training and attendance during the appointments at the family homes. Conclusion: Measuring height by photographic display is interesting for children and parents and can be used for height measurements at home. A positive response rate of 13 out of 14 families with altogether 22 children highlights feasible recruitment and the high convenience and user-friendliness of daily APP-supported height measurements. Daily APP measurements appear to be a promising new tool for longitudinal growth studies.},
  language  = {en}
}
@article{SchmitzAntonischkiHeideNetzebandt2022,
  author    = {Schmitz-Antonischki, Dorit and Heide, Judith and Netzebandt, Jonka},
  title     = {Therapie von Wortabrufst{\"o}rungen mit der App LingoTalk bei einer Patientin mit Aphasie},
  series = {Spektrum Patholinguistik 15},
  journal   = {Spektrum Patholinguistik 15},
  number    = {15},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-542-2},
  issn      = {1866-9433},
  doi       = {10.25932/publishup-57243},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-572433},
  pages     = {157 -- 171},
  year      = {2022},
  language  = {de}
}
@inproceedings{GebserHinrichsSchaubetal.2010,
  author    = {Gebser, Martin and Hinrichs, Henrik and Schaub, Torsten and Thiele, Sven},
  title     = {xpanda: a (simple) preprocessor for adding multi-valued propositions to ASP},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-41466},
  year      = {2010},
  abstract  = {We introduce a simple approach extending the input language of Answer Set Programming (ASP) systems by multi-valued propositions. Our approach is implemented as a (prototypical) preprocessor translating logic programs with multi-valued propositions into logic programs with Boolean propositions only. Our translation is modular and heavily benefits from the expressive input language of ASP. The resulting approach, along with its implementation, allows for solving interesting constraint satisfaction problems in ASP, showing a good performance.},
  language  = {en}
}
@misc{Janošikova2024,
  author    = {J{\´a}noš{\´i}kov{\´a}, Magdal{\´e}na},
  title     = {Jason Sion Mokhtarian, Medicine in the Talmud: Natural and Supernatural Therapies between Magic and Science (Berkeley, CA: University of California Press, 2022), 260 pp.},
  series = {PaRDeS},
  journal   = {PaRDeS},
  number    = {29},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-574-3},
  issn      = {1614-6492},
  doi       = {10.25932/publishup-65039},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-650392},
  pages     = {154 -- 157},
  year      = {2024},
  language  = {en}
}
@misc{Halbinger2024,
  author    = {Halbinger, Monika},
  title     = {Kateřina Čapkov{\´a}/Hillel J. Kieval (eds.), Prague and Beyond. Jews in the Bohemian Lands (Philadelphia, PA: University of Pennsylvania Press 2021), 384 pp.},
  series = {PaRDeS},
  journal   = {PaRDeS},
  number    = {29},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-574-3},
  issn      = {1614-6492},
  doi       = {10.25932/publishup-65030},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-650309},
  pages     = {151 -- 154},
  year      = {2024},
  language  = {de}
}
@misc{Kessler2024,
  author    = {Keßler, Katrin},
  title     = {Anke Geißler-Gr{\"u}nberg, J{\"u}discher Friedhof Potsdam: Dokumentation - Geschichte - Erinnerungsort (Wiesbaden: Harrassowitz, 2022). Teil 1: Geschichte, Gestaltung, Ort der Erinnerung, 289 S. + 1 eingelegter Plan. Teil 2: Dokumentation der Grabsteine und Grabanlagen, 780 S.},
  series = {PaRDeS},
  journal   = {PaRDeS},
  number    = {29},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-574-3},
  issn      = {1614-6492},
  doi       = {10.25932/publishup-65040},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-650401},
  pages     = {157 -- 160},
  year      = {2024},
  language  = {de}
}
@article{MaassKuehneHeinzeetal.2022,
  author    = {Maaß, Ulrike and K{\"u}hne, Franziska and Heinze, Peter Eric and Ay-Bryson, Destina Sevde and Weck, Florian},
  title     = {The concise measurement of clinical communication skills},
  series = {Frontiers in Psychiatry},
  volume    = {13},
  journal   = {Frontiers in Psychiatry},
  publisher = {Frontiers},
  address   = {Lausanne, Schweiz},
  issn      = {1664-0640},
  doi       = {10.3389/fpsyt.2022.977324},
  pages     = {10},
  year      = {2022},
  abstract  = {Objective: There is a lack of brief rating scales for the reliable assessment of psychotherapeutic skills, which do not require intensive rater training and/or a high level of expertise. Thus, the objective is to validate a 14-item version of the Clinical Communication Skills Scale (CCSS-S). Methods: Using a sample of N = 690 video-based ratings of role-plays with simulated patients, we calculated a confirmatory factor analysis and an exploratory structural equation modeling (ESEM), assessed convergent validities, determined inter-rater reliabilities and compared these with those who were either psychology students, advanced psychotherapy trainees, or experts. Results: Correlations with other competence rating scales were high (rs > 0.86-0.89). The intraclass correlations ranged between moderate and good [ICC(2,2) = 0.65-0.80], with student raters yielding the lowest scores. The one-factor model only marginally replicated the data, but the internal consistencies were excellent (α = 0.91-95). The ESEM yielded a two-factor solution (Collaboration and Structuring and Exploration Skills). Conclusion: The CCSS-S is a brief and valid rating scale that reliably assesses basic communication skills, which is particularly useful for psychotherapy training using standardized role-plays. To ensure good inter-rater reliabilities, it is still advisable to employ raters with at least some clinical experience. Future studies should further investigate the one- or two-factor structure of the instrument.},
  language  = {en}
}
@article{KasperMarienberg2024,
  author    = {Kasper-Marienberg, Verena},
  title     = {Imperial Transition and Early Modern Jewish Continuities},
  series = {PaRDeS},
  journal   = {PaRDeS},
  number    = {29},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-574-3},
  issn      = {1614-6492},
  doi       = {10.25932/publishup-65022},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-650224},
  pages     = {53 -- 66},
  year      = {2024},
  abstract  = {This article brings two seemingly disconnected historiographic models of periodization into conversation: Habsburg studies and Habsburg Jewish studies. It argues for an expansion of the temporal frameworks of both fields to highlight historical continuities connecting the Holy Roman and Habsburg Empire at least from a structural perspective. These historical continuums are a useful analytical lens when applied to marginalized groups, like early modern Jews, in tandem with a central group of contemporary powerholders, such as the Habsburg nobility. Using Bohemia as a case study, this essay juxtaposes questions of transregional transfer of cultural, economic, and social capital with the challenges of Jewish marginalization and discrimination to highlight the changing yet interconnected imperial landscapes.},
  language  = {en}
}
@article{Berkovich2024,
  author    = {Berkovich, Ilya},
  title     = {Jewish Mercenaries in Habsburg Service},
  series = {PaRDeS},
  journal   = {PaRDeS},
  number    = {29},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-574-3},
  issn      = {1614-6492},
  doi       = {10.25932/publishup-65023},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-650239},
  pages     = {69 -- 79},
  year      = {2024},
  abstract  = {This article aims to demonstrate the exceptional potential of Habsburg military records for the study of Jewish history during Europe's Age of Revolution. We begin with the random discovery of six Jewish veterans of Freikorps Gr{\"u}n Loudon - a unit of mercenary freebooters - which fought for the Habsburgs during the first war against the French Republic (1792 - 97). A careful re-reading of the available archival evidence reveals that these men were the survivors of a much larger group numbering at least two dozen Jewish soldiers. While Jewish conscripts had been drafted into the Habsburg army since 1788, the fact that Jews could also serve - even volunteer - as professional soldiers in that period is completely new to us. When considered together, the personal circumstances and service experiences of the Jewish soldiers of Freikorps Gr{\"u}n Loudon enable us to make several observations about their motivation as well as their position vis-{\`a}-vis their non-Jewish comrades.},
  language  = {en}
}
@article{Czakai2024,
  author    = {Czakai, Johannes},
  title     = {Between Legibility, Emancipation, and Markers of "Otherness"},
  series = {PaRDeS},
  journal   = {PaRDeS},
  number    = {29},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-574-3},
  issn      = {1614-6492},
  doi       = {10.25932/publishup-65024},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-650249},
  pages     = {81 -- 89},
  year      = {2024},
  abstract  = {The article analyzes the interdependences between the history of the Habsburg Empire and the names of its Jewish inhabitants. Until today, these names tell stories about this close relationship and they are an everlasting symbol of this era. By focusing on names, this paper shows how state policies towards Jews shifted over time, and how the perspective on names and name regulations can be a tool to connect and investigate both Habsburg and Jewish studies.},
  language  = {en}
}
@article{Stechauner2024,
  author    = {Stechauner, Martin},
  title     = {"Domestic Foreigners"},
  series = {PaRDeS},
  journal   = {PaRDeS},
  number    = {29},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-574-3},
  issn      = {1614-6492},
  doi       = {10.25932/publishup-65026},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-650260},
  pages     = {103 -- 112},
  year      = {2024},
  abstract  = {This paper examines the relationship between the Sephardic Jewish community of Vienna and the Ottoman and Habsburg Empires in the latter half of the 19th century. The community's legal status was transformed following the emancipation of Austrian Jews, but very few first-hand accounts of these changes exist today. The primary sources analyzed in this paper are Judezmo-language newspapers published in Vienna at that time. The paper emphasizes the historical and political contexts surrounding these sources, particularly the community's close ties to the Ottoman and Habsburg regimes.},
  language  = {en}
}
@article{Dodou2024,
  author    = {Dodou, Lida-Maria},
  title     = {"Austrian," "Jewish," "Salonican"},
  series = {PaRDeS},
  journal   = {PaRDeS},
  number    = {29},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-574-3},
  issn      = {1614-6492},
  doi       = {10.25932/publishup-65027},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-650271},
  pages     = {115 -- 123},
  year      = {2024},
  abstract  = {Even though Salonican Jews are not typically associated with the Habsburg Empire, some of them, nonetheless, lived there. This paper aims to examine the formation of these Salonican Jews' (self-)identification by studying their social interactions with the local Viennese population such as the Viennese Sephardi or the Greek-Orthodox communities. The change of the milieu within which they found themselves subsequently impacted their self-perception. Thus, the issue of the surrounding environment and their relations with other groups became central to their self-understanding, as will be demonstrated. By examining different aspects, like migration patterns, financial decisions and family ties, one can understand how their intersection influenced Salonica Jews' self-identification, which, at the same time, shaped and was shaped by the surrounding milieu. Within this framework, these people perceived themselves and were perceived as Salonican, Sephardi, Jewish, and as subjects of the Emperor.},
  language  = {en}
}
@article{MaślakMaciejewska2024,
  author    = {Maślak-Maciejewska, Alicja},
  title     = {Shared Spaces},
  series = {PaRDeS},
  journal   = {PaRDeS},
  number    = {29},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-574-3},
  issn      = {1614-6492},
  doi       = {10.25932/publishup-65025},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-650253},
  pages     = {91 -- 100},
  year      = {2024},
  abstract  = {Galicia was home to the largest Jewish population of the Cisleithanian part of the Habsburg Empire. After the Josephinian "German-Jewish schools" had closed already in 1806, educational patterns differed from those in Moravia and Bohemia, where Jewish children received a secular education in a more consistent "Jewish" space. In Galicia in the constitutional era (post-1867), however, with mandatory education enforced, public schools became a shared space in which Jews and (Catholic) Christians functioned together. In Galicia, most Jewish children received public education but usually constituted a religious minority in the student body. The article analyzes how the school space, calendar, and routines were adjusted to accommodate the multi-religious character of the student body.},
  language  = {en}
}
@misc{Piskačova2024,
  author    = {Piskačov{\´a}, Zora},
  title     = {Agnieszka Wierzcholska, Nur Erinnerungen und Steine sind geblieben. Leben und Sterben einer polnisch-j{\"u}dischen Stadt: Tarn{\´o}w 1918 - 1945 (Paderborn: Brill-Sch{\"o}ningh Verlag, 2022), 665 pp.},
  series = {PaRDeS},
  journal   = {PaRDeS},
  number    = {29},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-574-3},
  issn      = {1614-6492},
  doi       = {10.25932/publishup-65053},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-650538},
  pages     = {163 -- 167},
  year      = {2024},
  language  = {en}
}
@article{NasrCorbett2024,
  author    = {Nasr, Omar T. and Corbett, Tim},
  title     = {Diversifying Modern Austrian History},
  series = {PaRDeS},
  journal   = {PaRDeS},
  number    = {29},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-574-3},
  issn      = {1614-6492},
  doi       = {10.25932/publishup-65029},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-650290},
  pages     = {137 -- 147},
  year      = {2024},
  abstract  = {Jews and Muslims have lived in the territory of modern-day Austria for centuries untold, yet often continue to be construed as the essential "other." This essay explores a selection of sometimes divergent, sometimes convergent historical experiences amongst these two broad population groups, focusing specifically on demographic diversity, community-building, discrimination and persecution, and the post-war situation. The ultimate aim is to illuminate paradigmatically through the Austrian case study the complex multicultural mosaic of historical Central Europe, the understanding of which, so our contention, sheds a critical light on the often divisive present-day debates concerning immigration and diversity in Austria and Central Europe more broadly. It furthermore opens up a hitherto understudied field of historical research, namely the entangled history of Jews and Muslims in modern Europe.},
  language  = {en}
}
@article{BornhorstSeyfried2021,
  author    = {Bornhorst, Dorothee and Seyfried, Salim},
  title     = {Strong as a hippo's heart},
  series = {Frontiers in cell and developmental biology},
  volume    = {9},
  journal   = {Frontiers in cell and developmental biology},
  publisher = {Frontiers Media},
  address   = {Lausanne, Schweiz},
  issn      = {2296-634X},
  doi       = {10.3389/fcell.2021.731101},
  pages     = {1 -- 10},
  year      = {2021},
  abstract  = {The heart is comprised of multiple tissues that contribute to its physiological functions. During development, the growth of myocardium and endocardium is coupled and morphogenetic processes within these separate tissue layers are integrated. Here, we discuss the roles of mechanosensitive Hippo signaling in growth and morphogenesis of the zebrafish heart. Hippo signaling is involved in defining numbers of cardiac progenitor cells derived from the secondary heart field, in restricting the growth of the epicardium, and in guiding trabeculation and outflow tract formation. Recent work also shows that myocardial chamber dimensions serve as a blueprint for Hippo signaling-dependent growth of the endocardium. Evidently, Hippo pathway components act at the crossroads of various signaling pathways involved in embryonic zebrafish heart development. Elucidating how biomechanical Hippo signaling guides heart morphogenesis has direct implications for our understanding of cardiac physiology and pathophysiology.},
  language  = {en}
}
@inproceedings{OPUS4-1574,
  title     = {Clumping in hot-star winds : proceedings of an international workshop held in Potsdam, Germany, 18. - 22. June 2007},
  editor    = {Hamann, Wolf-Rainer and Feldmeier, Achim and Oskinova, Lidia M.},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-940793-33-1},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-13981},
  pages     = {254},
  year      = {2007},
  abstract  = {Stellar winds play an important role for the evolution of massive stars and their cosmic environment. Multiple lines of evidence, coming from spectroscopy, polarimetry, variability, stellar ejecta, and hydrodynamic modeling, suggest that stellar winds are non-stationary and inhomogeneous. This is referred to as 'wind clumping'. The urgent need to understand this phenomenon is boosted by its far-reaching implications. Most importantly, all techniques to derive empirical mass-loss rates are more or less corrupted by wind clumping. Consequently, mass-loss rates are extremely uncertain. Within their range of uncertainty, completely different scenarios for the evolution of massive stars are obtained. Settling these questions for Galactic OB, LBV and Wolf-Rayet stars is prerequisite to understanding stellar clusters and galaxies, or predicting the properties of first-generation stars. In order to develop a consistent picture and understanding of clumped stellar winds, an international workshop on 'Clumping in Hot Star Winds' was held in Potsdam, Germany, from 18. - 22. June 2007. About 60 participants, comprising almost all leading experts in the field, gathered for one week of extensive exchange and discussion. The Scientific Organizing Committee (SOC) included John Brown (Glasgow), Joseph Cassinelli (Madison), Paul Crowther (Sheffield), Alex Fullerton (Baltimore), Wolf-Rainer Hamann (Potsdam, chair), Anthony Moffat (Montreal), Stan Owocki (Newark), and Joachim Puls (Munich). These proceedings contain the invited and contributed talks presented at the workshop, and document the extensive discussions.},
  language  = {en}
}
@phdthesis{Martin2024,
  author    = {Martin, Johannes},
  title     = {Synthesis of protein-polymer conjugates and block copolymers via sortase-mediated ligation},
  doi       = {10.25932/publishup-64566},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-645669},
  school      = {Universit{\"a}t Potsdam},
  pages     = {XVII, 150},
  year      = {2024},
  abstract  = {In den vergangenen Jahrzehnten haben therapeutische Proteine in der pharmazeutischen Industrie mehr und mehr an Bedeutung gewonnen. Werden Proteine nichtmenschlichen Ursprungs verwendet, kann es jedoch zu einer Immunreaktion kommen, sodass das Protein sehr schnell aus dem K{\"o}rper ausgeschieden oder abgebaut wird. Um die Zirkulationszeit im Blut signifikant zu verl{\"a}ngern, werden die Proteine mit synthetischen Polymeren modifiziert (Protein-Polymer-Konjugate). Die Proteine aller heute auf dem Markt erh{\"a}ltlichen Medikamente dieser Art tragen eine oder mehrere Polymerketten aus Poly(ethylenglycol) (PEG). Ein Nachteil der PEGylierung ist, dass viele Patienten bei regelm{\"a}ßiger Einnahme dieser Medikamente Antik{\"o}rper gegen PEG entwickeln, die den effizienzsteigernden Effekt der PEGylierung wieder aufheben. Ein weiterer Nachteil der PEGylierung ist die oftmals deutlich verringerte Aktivit{\"a}t der Konjugate im Vergleich zum nativen Protein. Der Grund daf{\"u}r ist die Herstellungsmethode der Konjugate, bei der meist die prim{\"a}ren Amine der Lysin-Seitenketten und der N-Terminus des Proteins genutzt werden. Da die meisten Proteine mehrere gut zug{\"a}ngliche Lysine aufweisen, werden oft unterschiedliche und teilweise mehrere Lysine mit PEG funktionalisiert, was zu einer Mischung an Regioisomeren f{\"u}hrt. Je nach Position der PEG-Kette kann das aktive Zentrum abgeschirmt oder die 3D-Struktur des Proteins ver{\"a}ndert werden, was zu einem teilweise drastischen Aktivit{\"a}tsabfall f{\"u}hrt. In dieser Arbeit wurde eine neuartige Methode zur Ligation von Makromolek{\"u}len untersucht. Die Verwendung eines Enzyms als Katalysator zur Verbindung zweier Makromolek{\"u}le ist bisher wenig untersucht und ineffizient. Als Enzym wurde Sortase A ausgew{\"a}hlt, eine gut untersuchte Ligase aus der Familie der Transpeptidasen, welche die Ligation zweier Peptide katalysieren kann. Ein Nachteil dieser Sortase-vermittelten Ligation ist, dass es sich um eine Gleichgewichtsreaktion handelt, wodurch hohe Ausbeuten schwierig zu erreichen sind. Im Rahmen dieser Dissertation wurden zwei zuvor entwickelte Methoden zur Verschiebung des Gleichgewichts ohne Einsatz eines großen {\"U}berschusses von einem Edukt f{\"u}r Makromolek{\"u}le {\"u}berpr{\"u}ft. Zur Durchf{\"u}hrung der Sortase-vermittelten Ligation werden zwei komplement{\"a}re Peptidsequenzen verwendet, die Erkennungssequenz und das Nukleophil. Um eine systematische Untersuchung durchf{\"u}hren zu k{\"o}nnen, wurden alle n{\"o}tigen Bausteine (Protein-Erkennungssequenz zur Reaktion mit Nukleophil-Polymer und Polymer-Erkennungssequenz mit Nukleophil-Protein) hergestellt. Als Polymerisationstechnik wurde die radikalische Polymerisation mit reversibler Deaktivierung (im Detail, Atom Transfer Radical Polymerization, ATRP und Reversible Addition-Fragmentation Chain Transfer, RAFT polymerization) gew{\"a}hlt, um eine enge Molmassenverteilung zu erreichen. Die Herstellung der Bausteine begann mit der Synthese der Peptide via automatisierter Festphasen-Peptidsynthese, um eine einfache {\"A}nderung der Peptidsequenz zu gew{\"a}hrleisten und um eine Modifizierung der Polymerkette nach der Polymerisation zu umgehen. Um die ben{\"o}tigte unterschiedliche Funktionalit{\"a}t der zwei Peptidsequenzen (freier C-Terminus bei der Erkennungssequenz bzw. freier N-Terminus bei dem Nukleophil) zu erreichen, wurden verschiedene Linker zwischen Harz und Peptid verwendet. Danach wurde der Ketten{\"u}bertr{\"a}ger (chain transfer agent, CTA) zur Kontrolle der Polymerisation mit dem auf dem Harz befindlichen Peptid gekoppelt. Die f{\"u}r die anschließende Polymerisation verwendeten Monomere basierten auf Acrylamiden und Acrylaten und wurden anhand ihrer Eignung als Alternativen zu PEG ausgew{\"a}hlt. Es wurde eine k{\"u}rzlich entwickelte Technik basierend auf der RAFT-Polymerisation (xanthate-supported photo-iniferter RAFT, XPI-RAFT) verwendet um eine Reihe an Peptid-Polymeren mit unterschiedlichen Molekulargewichten und engen Molekulargewichtsverteilungen herzustellen. Nach Entfernung der Schutzgruppen der Peptid-Seitenketten wurden die Peptid-Polymere zun{\"a}chst genutzt, um mittels Sortase-vermittelter Ligation zwei Polymerketten zu einem Blockcopolymer zu verbinden. Unter Verwendung von Ni2+-Ionen in Kombination mit einer Verl{\"a}ngerung der Erkennungssequenz um ein Histidin zur Unterdr{\"u}ckung der R{\"u}ckreaktion konnte ein maximaler Umsatz von 70 \% erreicht werden. Dabei zeigte sich ein oberes Limit von durchschnittlich 100 Wiederholungseinheiten; die Ligation von l{\"a}ngeren Polymeren war nicht erfolgreich. Danach wurden ein Modellprotein und ein Nanobody mit vielversprechenden medizinischen Eigenschaften mit den f{\"u}r die enzymkatalysierte Ligation ben{\"o}tigten Peptidsequenzen f{\"u}r die Kopplung mit den zuvor hergestellten Peptid-Polymeren verwendet. Dabei konnte bei Verwendung des Modellproteins keine Bildung von Protein-Polymer-Konjugaten beobachtet werden. Der Nanobody konnte dagegen C-terminal mit einem Polymer funktionalisiert werden. Dabei wurde eine {\"a}hnliche Limitierung in der Polymer-Kettenl{\"a}nge beobachtet wie zuvor. Die auf Ni-Ionen basierte Strategie zur Gleichgewichtsverschiebung hatte hier keinen ausschlaggebenden Effekt, w{\"a}hrend die Verwendung von einem {\"U}berschuss an Polymer zur vollst{\"a}ndigen Umsetzung des Edukt-Nanobody f{\"u}hrte. Die erhaltenen Daten aus diesem Projekt bilden eine gute Basis f{\"u}r weitere Forschung in dem vielversprechenden Feld der enzymkatalysierten Herstellung von Protein-Polymer-Konjugaten und Blockcopolymeren. Langfristig k{\"o}nnte diese Herangehensweise eine vielseitig einsetzbare Herstellungsmethode von ortsspezifischen therapeutischen Protein-Polymer Konjugaten darstellen, welche sowohl eine hohe Aktivit{\"a}t als auch eine lange Zirkulationszeit im Blut aufweisen.},
  language  = {en}
}
@phdthesis{Videla2014,
  author    = {Videla, Santiago},
  title     = {Reasoning on the response of logical signaling networks with answer set programming},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-71890},
  school      = {Universit{\"a}t Potsdam},
  year      = {2014},
  abstract  = {Deciphering the functioning of biological networks is one of the central tasks in systems biology. In particular, signal transduction networks are crucial for the understanding of the cellular response to external and internal perturbations. Importantly, in order to cope with the complexity of these networks, mathematical and computational modeling is required. We propose a computational modeling framework in order to achieve more robust discoveries in the context of logical signaling networks. More precisely, we focus on modeling the response of logical signaling networks by means of automated reasoning using Answer Set Programming (ASP). ASP provides a declarative language for modeling various knowledge representation and reasoning problems. Moreover, available ASP solvers provide several reasoning modes for assessing the multitude of answer sets. Therefore, leveraging its rich modeling language and its highly efficient solving capacities, we use ASP to address three challenging problems in the context of logical signaling networks: learning of (Boolean) logical networks, experimental design, and identification of intervention strategies. Overall, the contribution of this thesis is three-fold. Firstly, we introduce a mathematical framework for characterizing and reasoning on the response of logical signaling networks. Secondly, we contribute to a growing list of successful applications of ASP in systems biology. Thirdly, we present a software providing a complete pipeline for automated reasoning on the response of logical signaling networks.},
  language  = {en}
}
@article{HeimannJelinek2024,
  author    = {Heimann-Jelinek, Felicitas},
  title     = {What was "Jewish" about the Old Jewish Museum of Vienna?},
  series = {PaRDeS},
  journal   = {PaRDeS},
  number    = {29},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-574-3},
  issn      = {1614-6492},
  doi       = {10.25932/publishup-65028},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-650283},
  pages     = {125 -- 134},
  year      = {2024},
  abstract  = {The Jewish museums established in the fin-de-si{\`e}cle Habsburg Empire postulated the unity of "the Jewish people," with custodians constructing an "us" (Jews) in distinction to the "other" (non-Jews). In the difference-oriented frenzy of the time, Jewish identity was predominantly presented as Central European, enlightened, not overly religious, and middle-class. Then, when the Viennese Jewish Museum opened its doors in 1895, the painters Isidor Kaufmann and David Kohn created an installation called "Die Gute Stube" (The Parlor). This exhibit housed books, furniture, as well as decorative and ritual objects of the kind that were thought to be found in typical Eastern European Jewish households. However, as this article argues, this attempted visualization of the essence of Judaism and the range of Jewish life worlds promoted a paradigmatic stereotype with which Jewish museums would have to struggle for decades to come.},
  language  = {en}
}
@misc{Arnold2024,
  author    = {Arnold, Rafael D.},
  title     = {Renata Segre, Preludio al Ghetto di Venezia: Gli ebrei sotto i dogi (1250 - 1516) (= Studi di storia, 15). (Venezia: Edizioni Ca' Foscari, 2021). 618 S.},
  series = {PaRDeS},
  journal   = {PaRDeS},
  number    = {29},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-574-3},
  issn      = {1614-6492},
  doi       = {10.25932/publishup-65123},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-651231},
  pages     = {167 -- 170},
  year      = {2024},
  language  = {de}
}
@misc{Shapira2024,
  author    = {Shapira, Elena},
  title     = {Charles Dellheim, Belonging and Betrayal: How Jews Made the Art World Modern (Waltham, MA: Brandeis University Press, 2021), 674 pp., 24 col./96 mono illus.},
  series = {PaRDeS},
  journal   = {PaRDeS},
  number    = {29},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-574-3},
  issn      = {1614-6492},
  doi       = {10.25932/publishup-65125},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-651252},
  pages     = {174 -- 177},
  year      = {2024},
  language  = {en}
}
@misc{Sidky2024,
  author    = {Sidky, Sean},
  title     = {Heike Bauer, Andrea Greenbaum, Sarah Lightman, eds., Jewish Women in Comics: Bodies and Borders (Syracuse, NY: Syracuse University Press, 2023), 296 pp.},
  series = {PaRDeS},
  journal   = {PaRDeS},
  number    = {29},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-574-3},
  issn      = {1614-6492},
  doi       = {10.25932/publishup-65126},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-651268},
  pages     = {178 -- 180},
  year      = {2024},
  language  = {en}
}
@misc{Kauders2024,
  author    = {Kauders, Anthony D.},
  title     = {Andrei S. Markovits, Der Pass ist mein Zuhause. Aufgefangen in Wurzellosigkeit (Berlin: Neofelis Verlag, 2022), 326 pp.},
  series = {PaRDeS},
  journal   = {PaRDeS},
  number    = {29},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-574-3},
  issn      = {1614-6492},
  doi       = {10.25932/publishup-65041},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-650417},
  pages     = {160 -- 163},
  year      = {2024},
  language  = {en}
}
@misc{Sun2024,
  author    = {Sun, Cheuk Him Ryan},
  title     = {Kathryn Hellerstein and Song Lihong (eds.), China and Ashkenazic Jewry: Transnational Encounters (Munich: De Gruyter Oldenbourg, 2022), 359 pp.},
  series = {PaRDeS},
  journal   = {PaRDeS},
  number    = {29},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-574-3},
  issn      = {1614-6492},
  doi       = {10.25932/publishup-65127},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-651277},
  pages     = {181 -- 185},
  year      = {2024},
  language  = {en}
}
@misc{Tusan2024,
  author    = {Tusan, Michelle Elizabeth},
  title     = {Jaclyn Granick, International Jewish Humanitarianism in the Age of the Great War (Cambridge, UK: Cambridge University Press, 2021), 418 pp.},
  series = {PaRDeS},
  journal   = {PaRDeS},
  number    = {29},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-574-3},
  issn      = {1614-6492},
  doi       = {10.25932/publishup-65129},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-651291},
  pages     = {187 -- 190},
  year      = {2024},
  language  = {en}
}
@misc{TiroshSamuelson2024,
  author    = {Tirosh-Samuelson, Hava},
  title     = {Andrea Dara Cooper, Gendering Modern Jewish Thought (Bloomington, IN: Indiana University Press, 2021), 270 pp.},
  series = {PaRDeS},
  journal   = {PaRDeS},
  number    = {29},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-574-3},
  issn      = {1614-6492},
  doi       = {10.25932/publishup-65128},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-651289},
  pages     = {185 -- 187},
  year      = {2024},
  language  = {en}
}
@misc{Weigand2024,
  author    = {Weigand, Susanne},
  title     = {Elisheva Baumgarten, Biblical Women and Jewish Daily Life in the Middle Ages (Philadelphia: University of Pennsylvania Press, 2022), 288 pp.},
  series = {PaRDeS},
  journal   = {PaRDeS},
  number    = {29},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-574-3},
  issn      = {1614-6492},
  doi       = {10.25932/publishup-65130},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-651300},
  pages     = {190 -- 192},
  year      = {2024},
  language  = {en}
}
@phdthesis{Brill2022,
  author    = {Brill, Fabio Alexander},
  title     = {Applications of machine learning and open geospatial data in flood risk modelling},
  doi       = {10.25932/publishup-55594},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-555943},
  school      = {Universit{\"a}t Potsdam},
  pages     = {xix, 124},
  year      = {2022},
  abstract  = {Der technologische Fortschritt erlaubt es, zunehmend komplexe Vorhersagemodelle auf Basis immer gr{\"o}ßerer Datens{\"a}tze zu produzieren. F{\"u}r das Risikomanagement von Naturgefahren sind eine Vielzahl von Modellen als Entscheidungsgrundlage notwendig, z.B. in der Auswertung von Beobachtungsdaten, f{\"u}r die Vorhersage von Gefahrenszenarien, oder zur statistischen Absch{\"a}tzung der zu erwartenden Sch{\"a}den. Es stellt sich also die Frage, inwiefern moderne Modellierungsans{\"a}tze wie das maschinelle Lernen oder Data-Mining in diesem Themenbereich sinnvoll eingesetzt werden k{\"o}nnen. Zus{\"a}tzlich ist im Hinblick auf die Datenverf{\"u}gbarkeit und -zug{\"a}nglichkeit ein Trend zur {\"O}ffnung (open data) zu beobachten. Thema dieser Arbeit ist daher, die M{\"o}glichkeiten und Grenzen des maschinellen Lernens und frei verf{\"u}gbarer Geodaten auf dem Gebiet der Hochwasserrisikomodellierung im weiteren Sinne zu untersuchen. Da dieses {\"u}bergeordnete Thema sehr breit ist, werden einzelne relevante Aspekte herausgearbeitet und detailliert betrachtet. Eine prominente Datenquelle im Bereich Hochwasser ist die satellitenbasierte Kartierung von {\"U}berflutungsfl{\"a}chen, die z.B. {\"u}ber den Copernicus Service der Europ{\"a}ischen Union frei zur Verf{\"u}gung gestellt werden. Große Hoffnungen werden in der wissenschaftlichen Literatur in diese Produkte gesetzt, sowohl f{\"u}r die akute Unterst{\"u}tzung der Einsatzkr{\"a}fte im Katastrophenfall, als auch in der Modellierung mittels hydrodynamischer Modelle oder zur Schadensabsch{\"a}tzung. Daher wurde ein Fokus in dieser Arbeit auf die Untersuchung dieser Flutmasken gelegt. Aus der Beobachtung, dass die Qualit{\"a}t dieser Produkte in bewaldeten und urbanen Gebieten unzureichend ist, wurde ein Verfahren zur nachtr{\"a}glichenVerbesserung mittels maschinellem Lernen entwickelt. Das Verfahren basiert auf einem Klassifikationsalgorithmus der nur Trainingsdaten von einer vorherzusagenden Klasse ben{\"o}tigt, im konkreten Fall also Daten von {\"U}berflutungsfl{\"a}chen, nicht jedoch von der negativen Klasse (trockene Gebiete). Die Anwendung f{\"u}r Hurricane Harvey in Houston zeigt großes Potenzial der Methode, abh{\"a}ngig von der Qualit{\"a}t der urspr{\"u}nglichen Flutmaske. Anschließend wird anhand einer prozessbasierten Modellkette untersucht, welchen Einfluss implementierte physikalische Prozessdetails auf das vorhergesagte statistische Risiko haben. Es wird anschaulich gezeigt, was eine Risikostudie basierend auf etablierten Modellen leisten kann. Solche Modellketten sind allerdings bereits f{\"u}r Flusshochwasser sehr komplex, und f{\"u}r zusammengesetzte oder kaskadierende Ereignisse mit Starkregen, Sturzfluten, und weiteren Prozessen, kaum vorhanden. Im vierten Kapitel dieser Arbeit wird daher getestet, ob maschinelles Lernen auf Basis von vollst{\"a}ndigen Schadensdaten einen direkteren Weg zur Schadensmodellierung erm{\"o}glicht, der die explizite Konzeption einer solchen Modellkette umgeht. Dazu wird ein staatlich erhobener Datensatz der gesch{\"a}digten Geb{\"a}ude w{\"a}hrend des schweren El Ni{\~n}o Ereignisses 2017 in Peru verwendet. In diesem Kontext werden auch die M{\"o}glichkeiten des Data-Mining zur Extraktion von Prozessverst{\"a}ndnis ausgelotet. Es kann gezeigt werden, dass diverse frei verf{\"u}gbare Geodaten n{\"u}tzliche Informationen f{\"u}r die Gefahren- und Schadensmodellierung von komplexen Flutereignissen liefern, z.B. satellitenbasierte Regenmessungen, topographische und hydrographische Information, kartierte Siedlungsfl{\"a}chen, sowie Indikatoren aus Spektraldaten. Zudem zeigen sich Erkenntnisse zu den Sch{\"a}digungsprozessen, die im Wesentlichen mit den vorherigen Erwartungen in Einklang stehen. Die maximale Regenintensit{\"a}t wirkt beispielsweise in St{\"a}dten und steilen Schluchten st{\"a}rker sch{\"a}digend, w{\"a}hrend die Niederschlagssumme in tiefliegenden Flussgebieten und bewaldeten Regionen als aussagekr{\"a}ftiger befunden wurde. L{\"a}ndliche Gebiete in Peru weisen in der pr{\"a}sentierten Studie eine h{\"o}here Vulnerabilit{\"a}t als die Stadtgebiete auf. Jedoch werden auch die grunds{\"a}tzlichen Grenzen der Methodik und die Abh{\"a}ngigkeit von spezifischen Datens{\"a}tzen and Algorithmen offenkundig. In der {\"u}bergreifenden Diskussion werden schließlich die verschiedenen Methoden - prozessbasierte Modellierung, pr{\"a}diktives maschinelles Lernen, und Data-Mining - mit Blick auf die Gesamtfragestellungen evaluiert. Im Bereich der Gefahrenbeobachtung scheint eine Fokussierung auf neue Algorithmen sinnvoll. Im Bereich der Gefahrenmodellierung, insbesondere f{\"u}r Flusshochwasser, wird eher die Verbesserung von physikalischen Modellen, oder die Integration von prozessbasierten und statistischen Verfahren angeraten. In der Schadensmodellierung fehlen nach wie vor die großen repr{\"a}sentativen Datens{\"a}tze, die f{\"u}r eine breite Anwendung von maschinellem Lernen Voraussetzung ist. Daher ist die Verbesserung der Datengrundlage im Bereich der Sch{\"a}den derzeit als wichtiger einzustufen als die Auswahl der Algorithmen.},
  language  = {en}
}
@phdthesis{Schifferle2024,
  author    = {Schifferle, Lukas},
  title     = {Optical properties of (Mg,Fe)O at high pressure},
  doi       = {10.25932/publishup-62216},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-622166},
  school      = {Universit{\"a}t Potsdam},
  pages     = {XIV, 90},
  year      = {2024},
  abstract  = {Large parts of the Earth's interior are inaccessible to direct observation, yet global geodynamic processes are governed by the physical material properties under extreme pressure and temperature conditions. It is therefore essential to investigate the deep Earth's physical properties through in-situ laboratory experiments. With this goal in mind, the optical properties of mantle minerals at high pressure offer a unique way to determine a variety of physical properties, in a straight-forward, reproducible, and time-effective manner, thus providing valuable insights into the physical processes of the deep Earth. This thesis focusses on the system Mg-Fe-O, specifically on the optical properties of periclase (MgO) and its iron-bearing variant ferropericlase ((Mg,Fe)O), forming a major planetary building block. The primary objective is to establish links between physical material properties and optical properties. In particular the spin transition in ferropericlase, the second-most abundant phase of the lower mantle, is known to change the physical material properties. Although the spin transition region likely extends down to the core-mantle boundary, the ef-fects of the mixed-spin state, where both high- and low-spin state are present, remains poorly constrained. In the studies presented herein, we show how optical properties are linked to physical properties such as electrical conductivity, radiative thermal conductivity and viscosity. We also show how the optical properties reveal changes in the chemical bonding. Furthermore, we unveil how the chemical bonding, the optical and other physical properties are affected by the iron spin transition. We find opposing trends in the pres-sure dependence of the refractive index of MgO and (Mg,Fe)O. From 1 atm to ~140 GPa, the refractive index of MgO decreases by ~2.4\% from 1.737 to 1.696 (±0.017). In contrast, the refractive index of (Mg0.87Fe0.13)O (Fp13) and (Mg0.76Fe0.24)O (Fp24) ferropericlase increases with pressure, likely because Fe Fe interactions between adjacent iron sites hinder a strong decrease of polarizability, as it is observed with increasing density in the case of pure MgO. An analysis of the index dispersion in MgO (decreasing by ~23\% from 1 atm to ~103 GPa) reflects a widening of the band gap from ~7.4 eV at 1 atm to ~8.5 (±0.6) eV at ~103 GPa. The index dispersion (between 550 and 870 nm) of Fp13 reveals a decrease by a factor of ~3 over the spin transition range (~44-100 GPa). We show that the electrical band gap of ferropericlase significantly widens up to ~4.7 eV in the mixed spin region, equivalent to an increase by a factor of ~1.7. We propose that this is due to a lower electron mobility between adjacent Fe2+ sites of opposite spin, explaining the previously observed low electrical conductivity in the mixed spin region. From the study of absorbance spectra in Fp13, we show an increasing covalency of the Fe-O bond with pressure for high-spin ferropericlase, whereas in the low-spin state a trend to a more ionic nature of the Fe-O bond is observed, indicating a bond weakening effect of the spin transition. We found that the spin transition is ultimately caused by both an increase of the ligand field-splitting energy and a decreasing spin-pairing energy of high-spin Fe2+.},
  language  = {en}
}
@phdthesis{Arend2024,
  author    = {Arend, Marius},
  title     = {Comparing genome-scale models of protein-constrained metabolism in heterotrophic and photosynthetic microorganisms},
  doi       = {10.25932/publishup-65147},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-651470},
  school      = {Universit{\"a}t Potsdam},
  pages     = {150},
  year      = {2024},
  abstract  = {Genome-scale metabolic models are mathematical representations of all known reactions occurring in a cell. Combined with constraints based on physiological measurements, these models have been used to accurately predict metabolic fluxes and effects of perturbations (e.g. knock-outs) and to inform metabolic engineering strategies. Recently, protein-constrained models have been shown to increase predictive potential (especially in overflow metabolism), while alleviating the need for measurement of nutrient uptake rates. The resulting modelling frameworks quantify the upkeep cost of a certain metabolic flux as the minimum amount of enzyme required for catalysis. These improvements are based on the use of in vitro turnover numbers or in vivo apparent catalytic rates of enzymes for model parameterization. In this thesis several tools for the estimation and refinement of these parameters based on in vivo proteomics data of Escherichia coli, Saccharomyces cerevisiae, and Chlamydomonas reinhardtii have been developed and applied. The difference between in vitro and in vivo catalytic rate measures for the three microorganisms was systematically analyzed. The results for the facultatively heterotrophic microalga C. reinhardtii considerably expanded the apparent catalytic rate estimates for photosynthetic organisms. Our general finding pointed at a global reduction of enzyme efficiency in heterotrophy compared to other growth scenarios. Independent of the modelled organism, in vivo estimates were shown to improve accuracy of predictions of protein abundances compared to in vitro values for turnover numbers. To further improve the protein abundance predictions, machine learning models were trained that integrate features derived from protein-constrained modelling and codon usage. Combining the two types of features outperformed single feature models and yielded good prediction results without relying on experimental transcriptomic data. The presented work reports valuable advances in the prediction of enzyme allocation in unseen scenarios using protein constrained metabolic models. It marks the first successful application of this modelling framework in the biotechnological important taxon of green microalgae, substantially increasing our knowledge of the enzyme catalytic landscape of phototrophic microorganisms.},
  language  = {en}
}
@article{ZurellKoenigMalchowetal.2022,
  author    = {Zurell, Damaris and K{\"o}nig, Christian and Malchow, Anne-Kathleen and Kapitza, Simon and Bocedi, Greta and Travis, Justin M. J. and Fandos, Guillermo},
  title     = {Spatially explicit models for decision-making in animal conservation and restoration},
  series = {Ecography : pattern and diversity in ecology / Nordic Ecologic Society Oikos},
  journal   = {Ecography : pattern and diversity in ecology / Nordic Ecologic Society Oikos},
  number    = {4},
  publisher = {Wiley-Blackwell},
  address   = {Oxford},
  issn      = {1600-0587},
  doi       = {10.1111/ecog.05787},
  pages     = {1 -- 16},
  year      = {2022},
  abstract  = {Models are useful tools for understanding and predicting ecological patterns and processes. Under ongoing climate and biodiversity change, they can greatly facilitate decision-making in conservation and restoration and help designing adequate management strategies for an uncertain future. Here, we review the use of spatially explicit models for decision support and to identify key gaps in current modelling in conservation and restoration. Of 650 reviewed publications, 217 publications had a clear management application and were included in our quantitative analyses. Overall, modelling studies were biased towards static models (79\%), towards the species and population level (80\%) and towards conservation (rather than restoration) applications (71\%). Correlative niche models were the most widely used model type. Dynamic models as well as the gene-to-individual level and the community-to-ecosystem level were underrepresented, and explicit cost optimisation approaches were only used in 10\% of the studies. We present a new model typology for selecting models for animal conservation and restoration, characterising model types according to organisational levels, biological processes of interest and desired management applications. This typology will help to more closely link models to management goals. Additionally, future efforts need to overcome important challenges related to data integration, model integration and decision-making. We conclude with five key recommendations, suggesting that wider usage of spatially explicit models for decision support can be achieved by 1) developing a toolbox with multiple, easier-to-use methods, 2) improving calibration and validation of dynamic modelling approaches and 3) developing best-practise guidelines for applying these models. Further, more robust decision-making can be achieved by 4) combining multiple modelling approaches to assess uncertainty, and 5) placing models at the core of adaptive management. These efforts must be accompanied by long-term funding for modelling and monitoring, and improved communication between research and practise to ensure optimal conservation and restoration outcomes.},
  language  = {en}
}
@article{KuehneFauthAyBrysonetal.2021,
  author    = {K{\"u}hne, Franziska and Fauth, Henriette and Ay-Bryson, Destina Sevde and Visser, Leonie N.C. and Weck, Florian},
  title     = {Communicating the diagnosis of cancer or depression},
  series = {Cancer medicine},
  volume    = {10},
  journal   = {Cancer medicine},
  number    = {24},
  publisher = {Wiley},
  address   = {Hoboken, New Jersey, USA},
  issn      = {2045-7634},
  doi       = {10.1002/cam4.4396},
  pages     = {9012 -- 9021},
  year      = {2021},
  abstract  = {Background Communicating a diagnosis is highly important, yet complex, especially in the context of cancer and mental disorders. The aim was to explore the communication style of an oncologist vs. psychotherapist in an online study. Methods Patients (N = 136: 65 cancer, 71 depression) were randomly assigned to watch a standardized video vignette with one of two communication styles (empathic vs. unempathic). Outcome measures of affectivity, information recall, communication skills, empathy and trust were applied. Results Regardless of diagnosis, empathic communication was associated with the perception of a significantly more empathic (p < 0.001, η2partial = 0.08) and trustworthy practitioner (p = 0.014, η2partial = 0.04) with better communication skills (p = 0.013, η2partial = 0.05). Cancer patients reported a larger decrease in positive affect (p < 0.001, η2partial = 0.15) and a larger increase in negative affect (p < 0.001, η2partial = 0.14) from pre- to post-video than depressive patients. Highly relevant information was recalled better in both groups (p < 0.001, d = 0.61-1.06). Conclusions The results highlight the importance of empathy while communicating both a diagnosis of cancer and a mental disorder. Further research should focus on the communication of a mental disorder in association with cancer.},
  language  = {en}
}