@book{Deppner2017,
  author    = {Deppner, Corinna},
  title     = {El Aleph},
  number    = {10},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-375-6},
  issn      = {1863-7442},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-98422},
  publisher      = {Universit{\"a}t Potsdam},
  pages     = {162},
  year      = {2017},
  abstract  = {Der argentinische Schriftsteller Jorge Luis Borges (1899-1986) gilt als ein Literat, der bereits in seinen Werken der 30er und 40er Jahre des 20. Jahrhunderts Strukturen geschaffen hat, die sp{\"a}ter die Postmoderne pr{\"a}gen sollten. Foucault hat sich auf ihn berufen. Borges Erz{\"a}hlungen sind insbesondere von intertextuellen Bezugnahmen und sich in Paradoxien verstrickende Narrative durchzogen. Die Folge ist ein dezentrierter sowie dialogisierender Text, der keine eindeutige Aussage hervorbringt, sondern in einer vielstimmigen und unabgeschlossenen Textauslegung zur Wirkung kommt. Die vorliegende Studie stellt zur Diskussion, ob ein wesentlicher Grund f{\"u}r Borges' innovatives, die literarische Postmoderne pr{\"a}gendes Textkonzept darin gesehen werden kann, dass sich der argentinische Schriftsteller nachweislich mit j{\"u}discher Schriftkultur auseinandergesetzt hat. Geht man davon aus, dass die in j{\"u}discher Tradition kultivierte mehrschichtige Textdeutung zugleich einen permanenten, unendlichen Rezeptionsprozess zur Folge hat wird deutlich, dass diese Tradition nicht nur kompatibel zu Borges' Literatur ist, sondern auch zahlreiche Reflexionen in der modernen Literatur und Literaturforschung angeregt hat.},
  language  = {de}
}
@phdthesis{Yishai2019,
  author    = {Yishai, Oren},
  title     = {Engineering the reductive glycine pathway in Escherichia coli},
  school      = {Universit{\"a}t Potsdam},
  pages     = {86},
  year      = {2019},
  language  = {en}
}
@book{PresslerRoggan2019,
  author    = {Preßler, Tobias and Roggan, Alfred},
  title     = {Sorbische/Wendische Spuren in der n{\"o}rdlichen Niederlausitz},
  series = {Podstupimske pśinoski k Sorabistice = Potsdamer Beitr{\"a}ge zur Sorabistik},
  journal   = {Podstupimske pśinoski k Sorabistice = Potsdamer Beitr{\"a}ge zur Sorabistik},
  number    = {12},
  editor    = {Norberg, Madlena and Kosta, Peter},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-478-4},
  issn      = {1615-2476},
  doi       = {10.25932/publishup-43693},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-436933},
  publisher      = {Universit{\"a}t Potsdam},
  pages     = {185},
  year      = {2019},
  abstract  = {Die Herausgeber der „Potsdamer Beitr{\"a}ge zur Sorabistik/Podstupimske pśinoski k Sorbistice" sind erfreut, nach l{\"a}ngerer Pause einen neuen Band ver{\"o}ffentlichen zu k{\"o}nnen. Gemeinschaftlich legen der Kulturwissenschaftler Tobias Preßler, welcher hier deb{\"u}tiert, und der ausgewiesene Denkmalpfleger i. R. Alfred Roggan, vier Artikel zur niedersorbischen Kulturgeschichte vor. Die Autoren widmen sich der sorbischen Sprache im Norden der Niederlausitz, ihrer ehemaligen Verbreitung und den Umst{\"a}nden ihres Verschwindens. Alle Beitr{\"a}ge n{\"a}hern sich aus unterschiedlicher Perspektive diesem Thema, wobei die Schwerpunkte auf verschiedenen Zeiten und Regionen liegen. Mit Paul Thol wird sich einem Restaurator und K{\"u}nstler zugewandt, dessen Werk und Schaffen in die bewegte 1. H{\"a}lfte des 20. Jahrhunderts f{\"a}llt. Diese Zeit bildet gleichsam den Abschluss einer epochen{\"u}bergreifenden Darstellung zur Politik gegen{\"u}ber den Sorben und ihrer Sprache, welche ein weiterer Artikel skizziert. In den beiden Herzst{\"u}cken des Bandes wird der Leser in die fr{\"u}he Neuzeit entf{\"u}hrt. Es wird ein bisher wenig beachtetes Druckwerk aus dem Jahre 1694 vorgestellt, das seinerzeit bewusst in zw{\"o}lf Sprachen herausgegeben wurde. Als wahres Kleinod der sorbischen Sprachgeschichte findet sich dieses Werk - ein Gedicht - {\"u}berliefert, das in einem nunmehr ausgestorbenen Dialektzweig verfasst ist. Neben dem Gedicht selbst, werden auch dessen bisherige literarische Bearbeitungen sowie der Entstehungshintergrund des Druckes eingehender beschrieben. Der vierte Beitrag widmet sich einer Region, in welcher wohl der gleiche Dialekt wie der des Gedichtes gesprochen wurde. Bis zum Verklingen der Sprache im 18. Jahrhundert war sie hier genauso lebendig wie sie es heute noch in ihrem Kerngebiet ist.},
  language  = {de}
}
@article{BeusterElkinaFortenbacheretal.2013,
  author    = {Beuster, Liane and Elkina, Margarita and Fortenbacher, Albrecht and Kappe, Leonard and Merceron, Agathe and Pursian, Andreas and Schwarzrock, Sebastian and Wenzlaff, Boris},
  title     = {Prototyp einer plattformunabh{\"a}ngigen Learning Analytics Applikation - fokussiert auf Nutzungsanalyse und Pfadanalyse},
  series = {E-Learning Symposium 2012 : Aktuelle Anwendungen, innovative Prozesse und neueste Ergebnisse aus der E-Learning-Praxis ; Potsdam, 17. November 2012},
  journal   = {E-Learning Symposium 2012 : Aktuelle Anwendungen, innovative Prozesse und neueste Ergebnisse aus der E-Learning-Praxis ; Potsdam, 17. November 2012},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  doi       = {10.25932/publishup-44216},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-442166},
  pages     = {69 -- 72},
  year      = {2013},
  abstract  = {Bei der hier vorgestellten Anwendung handelt es sich um den Prototypen einer webbasierten Applikation zur Analyse von Nutzungsdaten der AnwenderInnen von eLearning-Angeboten. Die Applikation wurde dabei explizit f{\"u}r unterschiedliche Zielgruppen wie eLearning-AnbieterInnen, Lehrende und WissenschaftlerInnen entworfen. Die Anwendung kann Daten verschiedener Lernplattformen auswerten und nutzt hierbei Methoden des Educational Data Mining. Sie unterst{\"u}tzt dabei sowohl klassische Plattformen mit personalisiertem Zugang sowie offene Plattformen, deren Angebote ohne Registrierung zug{\"a}nglich sind.},
  language  = {de}
}
@phdthesis{RuizRodriguez2019,
  author    = {Ruiz Rodriguez, Janete Lorena},
  title     = {Osmotic pressure effects on collagen mimetic peptides},
  school      = {Universit{\"a}t Potsdam},
  pages     = {139},
  year      = {2019},
  abstract  = {Collagen is the most abundant protein in mammals. In many tissues, collagen molecules assemble to form a hierarchical structure. In the smallest supramolecular unit, named fibril, each molecule is displaced in the axial direction with respect to its neighbors. This staggering creates a periodic gap and overlap regions, where the gap regions exhibit 20\% less density. These fibril-forming collagens play an essential role in the strength of connective tissues. Despite much effort, directed at understanding collagen function and regulation, the influence of the chemical environment on the local structural and mechanical properties remains poorly understood. Recent studies, aimed at elucidating the effect of osmotic pressure, showed that collagen contracts upon water removal. This observation highlights the importance of water for the stabilization and mechanics of the collagen molecule. Using collagen mimetic peptides (CMPs), which fold into triple helical structures reminiscent of natural collagen, the primary goal of this work was to investigate the effect of the osmotic pressure on specific collagen-mimetic sequences. CMPs were used as the model system as they provide sequence control, which is essential for discriminating local from global structural changes and for relating the observed effects to existing knowledge about the full-length collagen molecule. Of specific interest was the structure of individual collagen triple helices as well as their organization into self-assembled higher order structures. These key structural features were monitored with infrared spectroscopy (IR) and synchrotron X-ray scattering, while varying the osmotic pressure. For controlling the osmotic pressure, CMP powder samples were incubated in air of defined relative humidity, ranging from dry conditions to highly "humid". In addition, to obtain more biologically relevant conditions, the CMPs were measured in ultrapure water and in solutions containing small molecule osmolytes. Using the sequences (Pro-Pro-Gly)10, (Pro-Hyp-Gly)10 and (Hyp-Hyp-Gly)10, it was shown that CMPs with different degrees of proline hydroxylation (Hyp = hydroxyproline) exhibit a sequence-specific response to osmotic pressure. IR spectroscopy revealed that osmotic pressure changes affect the strength of the triple helix stabilizing, interchain hydrogen bond and that the extent of this change depends on the degree of hydroxylation. X-ray scattering experiments further showed that changes in osmotic pressure affect both the molecular length as well as the higher order organization of CMPs. Starting from a pseudo-hexagonal packing in the dry state, all three CMPs showed isotropic swelling when increasing the water content to approximately 1.2 water molecules per amino acid, again to different extents depending on the degree of hydroxylation. When increasing the water content further, this pseudo-hexagonal arrangement breaks down. In the fully hydrated state, each CMP is characterized by its own specific and more complex packing geometry. While these changes in the lateral packing arrangement suggest swelling upon hydration, an overall decrease of the molecular length (i.e. contraction) was observed in the axial direction. Also for this structural feature, a strong dependency on the specific amino acid sequence was found. Interestingly, the observed contraction is the opposite of what has been reported for natural collagen. As (Pro-Pro-Gly)n, (Pro-Hyp-Gly)n and (Hyp-Hyp-Gly)n repeat units are found in collagen with a relatively high abundance, this suggests that other collagen sequence fragments need to respond to hydration in the opposite way to obtain a net elongation of the full-length collagen molecule. To test this hypothesis, sequences predicted to be sensitive to osmotic pressure were considered. One such sequence, consisting of two repeat units (Ala-Arg-Gly-Ser-Asp-Gly), was inserted as a guest into a (Pro-Pro-Gly) host. When compared to the canonical CMP sequences investigated earlier, the lateral helix packing follows a similar trend with increasing hydration; however, the host-guest CMP axially elongates with increasing water content. This behavior is more similar to what has been found for natural collagen and suggests that different sequences do determine the molecular length of collagen sequences differently. Interestingly, the canonical sequences are more abundant in the overlap region while the guest sequence is found in the gap region. This allows to speculate that sequences in the gap and overlap regions possess a specifically fine-tuned local response to osmotic pressure changes. Clearly, more experiments with additional sequences are needed to confirm this. In conclusion, the results obtained in this work indicate a highly sequence specific interaction between collagen and water. Osmotic pressure-induced conformational changes mostly originate from local geometries and bonding patterns and affect both the structure of individual triple helices as well as higher order assemblies. One key remaining question is how these conformational changes affect the local mechanical properties of the collagen molecule. As a first step, the stiffness (persistence length) of full-length collagen was determined using atomic force microscopy. In the future, experimental strategies need to be developed that allow for investigating the mechanical properties of specific collagen sequences, e.g. performing single-molecule force spectroscopy of CMPs.},
  language  = {en}
}
@article{SmirnovBolotovBolotovetal.2022,
  author    = {Smirnov, Lev A. and Bolotov, Maxim and Bolotov, Dmitri and Osipov, Grigory V. and Pikovsky, Arkady},
  title     = {Finite-density-induced motility and turbulence of chimera solitons},
  series = {New Journal of Physics},
  volume    = {24},
  journal   = {New Journal of Physics},
  publisher = {IOP},
  address   = {London},
  issn      = {1367-2630},
  doi       = {10.1088/1367-2630/ac63d9},
  pages     = {15},
  year      = {2022},
  abstract  = {We consider a one-dimensional oscillatory medium with a coupling through a diffusive linear field. In the limit of fast diffusion this setup reduces to the classical Kuramoto-Battogtokh model. We demonstrate that for a finite diffusion stable chimera solitons, namely localized synchronous domain in an infinite asynchronous environment, are possible. The solitons are stable also for finite density of oscillators, but in this case they sway with a nearly constant speed. This finite-density-induced motility disappears in the continuum limit, as the velocity of the solitons is inverse proportional to the density. A long-wave instability of the homogeneous asynchronous state causes soliton turbulence, which appears as a sequence of soliton mergings and creations. As the instability of the asynchronous state becomes stronger, this turbulence develops into a spatio-temporal intermittency.},
  language  = {en}
}
@phdthesis{Littmann2024,
  author    = {Littmann, Daniela-Christin},
  title     = {Large eddy simulations of the Arctic boundary layer around the MOSAiC drift track},
  doi       = {10.25932/publishup-62437},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-624374},
  school      = {Universit{\"a}t Potsdam},
  pages     = {xii, 110},
  year      = {2024},
  abstract  = {The icosahedral non-hydrostatic large eddy model (ICON-LEM) was applied around the drift track of the Multidisciplinary Observatory Study of the Arctic (MOSAiC) in 2019 and 2020. The model was set up with horizontal grid-scales between 100m and 800m on areas with radii of 17.5km and 140 km. At its lateral boundaries, the model was driven by analysis data from the German Weather Service (DWD), downscaled by ICON in limited area mode (ICON-LAM) with horizontal grid-scale of 3 km. The aim of this thesis was the investigation of the atmospheric boundary layer near the surface in the central Arctic during polar winter with a high-resolution mesoscale model. The default settings in ICON-LEM prevent the model from representing the exchange processes in the Arctic boundary layer in accordance to the MOSAiC observations. The implemented sea-ice scheme in ICON does not include a snow layer on sea-ice, which causes a too slow response of the sea-ice surface temperature to atmospheric changes. To allow the sea-ice surface to respond faster to changes in the atmosphere, the implemented sea-ice parameterization in ICON was extended with an adapted heat capacity term. The adapted sea-ice parameterization resulted in better agreement with the MOSAiC observations. However, the sea-ice surface temperature in the model is generally lower than observed due to biases in the downwelling long-wave radiation and the lack of complex surface structures, like leads. The large eddy resolving turbulence closure yielded a better representation of the lower boundary layer under strongly stable stratification than the non-eddy-resolving turbulence closure. Furthermore, the integration of leads into the sea-ice surface reduced the overestimation of the sensible heat flux for different weather conditions. The results of this work help to better understand boundary layer processes in the central Arctic during the polar night. High-resolving mesoscale simulations are able to represent temporally and spatially small interactions and help to further develop parameterizations also for the application in regional and global models.},
  language  = {en}
}
@phdthesis{WindirschWoiwode2024,
  author    = {Windirsch-Woiwode, Torben},
  title     = {Permafrost carbon stabilisation by recreating a herbivore-driven ecosystem},
  doi       = {10.25932/publishup-62424},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-624240},
  school      = {Universit{\"a}t Potsdam},
  pages     = {X, 104, A-57},
  year      = {2024},
  abstract  = {With Arctic ground as a huge and temperature-sensitive carbon reservoir, maintaining low ground temperatures and frozen conditions to prevent further carbon emissions that contrib-ute to global climate warming is a key element in humankind's fight to maintain habitable con-ditions on earth. Former studies showed that during the late Pleistocene, Arctic ground condi-tions were generally colder and more stable as the result of an ecosystem dominated by large herbivorous mammals and vast extents of graminoid vegetation - the mammoth steppe. Characterised by high plant productivity (grassland) and low ground insulation due to animal-caused compression and removal of snow, this ecosystem enabled deep permafrost aggrad-ation. Now, with tundra and shrub vegetation common in the terrestrial Arctic, these effects are not in place anymore. However, it appears to be possible to recreate this ecosystem local-ly by artificially increasing animal numbers, and hence keep Arctic ground cold to reduce or-ganic matter decomposition and carbon release into the atmosphere. By measuring thaw depth, total organic carbon and total nitrogen content, stable carbon iso-tope ratio, radiocarbon age, n-alkane and alcohol characteristics and assessing dominant vegetation types along grazing intensity transects in two contrasting Arctic areas, it was found that recreating conditions locally, similar to the mammoth steppe, seems to be possible. For permafrost-affected soil, it was shown that intensive grazing in direct comparison to non-grazed areas reduces active layer depth and leads to higher TOC contents in the active layer soil. For soil only frozen on top in winter, an increase of TOC with grazing intensity could not be found, most likely because of confounding factors such as vertical water and carbon movement, which is not possible with an impermeable layer in permafrost. In both areas, high animal activity led to a vegetation transformation towards species-poor graminoid-dominated landscapes with less shrubs. Lipid biomarker analysis revealed that, even though the available organic material is different between the study areas, in both permafrost-affected and sea-sonally frozen soils the organic material in sites affected by high animal activity was less de-composed than under less intensive grazing pressure. In conclusion, high animal activity af-fects decomposition processes in Arctic soils and the ground thermal regime, visible from reduced active layer depth in permafrost areas. Therefore, grazing management might be utilised to locally stabilise permafrost and reduce Arctic carbon emissions in the future, but is likely not scalable to the entire permafrost region.},
  language  = {en}
}
@inproceedings{RehakStreckerEchtler2006,
  author    = {Rehak, Katrin and Strecker, Manfred and Echtler, Helmut Peter},
  title     = {DEM supported tectonic geomorphology : the Coastal Cordillera of the South-Central Chilean active margin ; [Poster]},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-7224},
  year      = {2006},
  abstract  = {Fluvial systems are one of the major features shaping a landscape. They adjust to the prevailing tectonic and climatic setting and therefore are very sensitive markers of changes in these systems. If their response to tectonic and climatic forcing is quantified and if the climatic signal is excluded, it is possible to derive a local deformation history. Here, we investigate fluvial terraces and erosional surfaces in the southern Chilean forearc to assess a long-term geomorphic and hence tectonic evolution. Remote sensing and field studies of the Nahuelbuta Range show that the long-term deformation of the Chilean forearc is manifested by breaks in topography, sequences of differentially uplifted marine, alluvial and strath terraces as well as tectonically modified river courses and drainage basins. We used SRTM-90-data as basic elevation information for extracting and delineating drainage networks. We calculated hypsometric curves as an indicator for basin uplift, stream-length gradient indices to identify stream segments with anomalous slopes, and longitudinal river profiles as well as DS-plots to identify knickpoints and other anomalies. In addition, we investigated topography with elevation-slope graphs, profiles, and DEMs to reveal erosional surfaces. During the first field trip we already measured palaeoflow directions, performed pebble counting and sampled the fluvial terraces in order to apply cosmogenic nuclide dating (<sup>10Be, <sup>26Al) as well as provenance analyses. Our preliminary analysis of the Coastal Cordillera indicates a clear segmentation between the northern and southern parts of the Nahuelbuta Range. The Lanalhue Fault, a NW-SE striking fault zone oblique to the plate boundary, defines the segment boundary. Furthermore, we find a complex drainage re-organisation including a drainage reversal and wind gap on the divide between the Tir{\´u}a and Pellahu{\´e}n basins east of the town Tir{\´u}a. The coastal basins lost most of their Andean sediment supply areas that existed in Tertiary and in part during early Pleistocene time. Between the B{\´i}o-B{\´i}o and Imperial rivers no Andean river is recently capable to traverse the Coastal Cordillera, suggesting ongoing Quaternary uplift of the entire range. From the spatial distribution of geomorphic surfaces in this region two uplift signals may be derived: (1) a long-term differential uplift process, active since the Miocene and possibly caused by underplating of subducted trench sediments, (2) a younger, local uplift affecting only the northern part of the Nahuelbuta Range that may be caused by the interaction of the forearc with the subduction of the Mocha Fracture Zone at the latitude of the Arauco peninsula. Our approach thus provides results in our attempt to decipher the characteristics of forearc development of active convergent margins using long-term geomorphic indicators. Furthermore, it is expected that our ongoing assessment will constrain repeatedly active zones of deformation. <hr> Interdisziplin{\"a}res Zentrum f{\"u}r Musterdynamik und Angewandte Fernerkundung Workshop vom 9. - 10. Februar 2006},
  language  = {en}
}
@phdthesis{Behrens2018,
  author    = {Behrens, Ricarda},
  title     = {Causes for slow weathering and erosion in the steep, warm, monsoon-subjected Highlands of Sri Lanka},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-408503},
  school      = {Universit{\"a}t Potsdam},
  pages     = {ix, 107, XXIV},
  year      = {2018},
  abstract  = {In the Highlands of Sri Lanka, erosion and chemical weathering rates are among the lowest for global mountain denudation. In this tropical humid setting, highly weathered deep saprolite profiles have developed from high-grade metamorphic charnockite during spheroidal weathering of the bedrock. The spheroidal weathering produces rounded corestones and spalled rindlets at the rock-saprolite interface. I used detailed textural, mineralogical, chemical, and electron-microscopic (SEM, FIB, TEM) analyses to identify the factors limiting the rate of weathering front advance in the profile, the sequence of weathering reactions, and the underlying mechanisms. The first mineral attacked by weathering was found to be pyroxene initiated by in situ Fe oxidation, followed by in situ biotite oxidation. Bulk dissolution of the primary minerals is best described with a dissolution - re-precipitation process, as no chemical gradients towards the mineral surface and sharp structural boundaries are observed at the nm scale. Only the local oxidation in pyroxene and biotite is better described with an ion by ion process. The first secondary phases are oxides and amorphous precipitates from which secondary minerals (mainly smectite and kaolinite) form. Only for biotite direct solid state transformation to kaolinite is likely. The initial oxidation of pyroxene and biotite takes place in locally restricted areas and is relatively fast: log J = -11 molmin/(m2 s). However, calculated corestone-scale mineral oxidation rates are comparable to corestone-scale mineral dissolution rates: log R = -13 molpx/(m2 s) and log R = -15 molbt/(m2 s). The oxidation reaction results in a volume increase. Volumetric calculations suggest that this observed oxidation leads to the generation of porosity due to the formation of micro-fractures in the minerals and the bedrock allowing for fluid transport and subsequent dissolution of plagioclase. At the scale of the corestone, this fracture reaction is responsible for the larger fractures that lead to spheroidal weathering and to the formation of rindlets. Since these fractures have their origin from the initial oxidational induced volume increase, oxidation is the rate limiting parameter for weathering to take place. The ensuing plagioclase weathering leads to formation of high secondary porosity in the corestone over a distance of only a few cm and eventually to the final disaggregation of bedrock to saprolite. As oxidation is the first weathering reaction, the supply of O2 is a rate-limiting factor for chemical weathering. Hence, the supply of O2 and its consumption at depth connects processes at the weathering front with erosion at the surface in a feedback mechanism. The strength of the feedback depends on the relative weight of advective versus diffusive transport of O2 through the weathering profile. The feedback will be stronger with dominating diffusive transport. The low weathering rate ultimately depends on the transport of O2 through the whole regolith, and on lithological factors such as low bedrock porosity and the amount of Fe-bearing primary minerals. In this regard the low-porosity charnockite with its low content of Fe(II) bearing minerals impedes fast weathering reactions. Fresh weatherable surfaces are a pre-requisite for chemical weathering. However, in the case of the charnockite found in the Sri Lankan Highlands, the only process that generates these surfaces is the fracturing induced by oxidation. Tectonic quiescence in this region and low pre-anthropogenic erosion rate (attributed to a dense vegetation cover) minimize the rejuvenation of the thick and cohesive regolith column, and lowers weathering through the feedback with erosion.},
  language  = {en}
}
@article{SchjeideSchenkeSeegeretal.2022,
  author    = {Schjeide, Brit-Maren and Schenke, Maren and Seeger, Bettina and P{\"u}schel, Gerhard},
  title     = {Validation of a novel double control quantitative copy number PCR method to quantify off-target transgene integration after CRISPR-induced DNA modification},
  series = {Methods and protocols : M\&Ps},
  volume    = {5},
  journal   = {Methods and protocols : M\&Ps},
  number    = {3},
  publisher = {MDPI},
  address   = {Basel, Schweiz},
  issn      = {2409-9279},
  doi       = {10.3390/mps5030043},
  pages     = {1 -- 14},
  year      = {2022},
  abstract  = {In order to improve a recently established cell-based assay to assess the potency of botulinum neurotoxin, neuroblastoma-derived SiMa cells and induced pluripotent stem-cells (iPSC) were modified to incorporate the coding sequence of a reporter luciferase into a genetic safe harbor utilizing CRISPR/Cas9. A novel method, the double-control quantitative copy number PCR (dc-qcnPCR), was developed to detect off-target integrations of donor DNA. The donor DNA insertion success rate and targeted insertion success rate were analyzed in clones of each cell type. The dc-qcnPCR reliably quantified the copy number in both cell lines. The probability of incorrect donor DNA integration was significantly increased in SiMa cells in comparison to the iPSCs. This can possibly be explained by the lower bundled relative gene expression of a number of double-strand repair genes (BRCA1, DNA2, EXO1, MCPH1, MRE11, and RAD51) in SiMa clones than in iPSC clones. The dc-qcnPCR offers an efficient and cost-effective method to detect off-target CRISPR/Cas9-induced donor DNA integrations.},
  language  = {en}
}
@inproceedings{WedernikovSlivaEbseevetal.2013,
  author    = {Wedernikov, Nikolaij T. and Sliva, Anatolij J. and Ebseev, Boris S. and Mitjukov, Mitjukov, Michail Alekseevič and Bobrowa, Vera K. and Yustus, Ekaterina and Postier, R{\"u}diger and Schulze, Carola and Hoof, Karsten and Steinhorst, Lars and Straschun, Boris A. and Narutto, Svetlana Vasil'evna and Michaleva, Nadezda A. and Fadeev, Vladimir Ivanovič and Warlen, Maria V.},
  title     = {Verfassungsgerichtsbarkeit in der Russischen F{\"o}deration und in der Bundesrepublik Deutschland},
  editor    = {Schulze, Carola and Fadeev, Vladimir Ivanovič},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  organization    = {Universit{\"a}t Potsdam, Juristische Fakult{\"a}t},
  isbn      = {978-3-86956-267-4},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-67861},
  pages     = {XX, 152},
  year      = {2013},
  abstract  = {Der Tagungsband enth{\"a}lt die Referate und Diskussionsbeitr{\"a}ge des in Moskau an der Staatlichen Juristischen Kutafin-Universit{\"a}t am 9. und 10. Oktober 2012 durchgef{\"u}hrten Rundtischgespr{\"a}ches zur Verfassungsgerichtsbarkeit. Behandelt werden ausgew{\"a}hlte rechtshistorische und -politische Fragen sowie aktuelle rechtliche Probleme der Verfassungsgerichtsbarkeit in der Russischen F{\"o}deration und der Bundesrepublik Deutschland sowohl aus der Sicht der Rechtspraxis als auch der Wissenschaft: insbesondere die Entwicklung der Verfassungsgerichtsbarkeit in Geschichte und Gegenwart, Status, Rechtsnatur und Aufgaben des Verfassungsgerichts in den Subjekten der F{\"o}deration und in den L{\"a}ndern sowie Verfassungsgericht und Gesetzgebung. Zudem werden Spezialfragen der Verfassungsgerichtsbarkeit er{\"o}rtert, z.B. die Institution des Bevollm{\"a}chtigten Vertreters des Pr{\"a}sidenten im Verfassungsgericht in Russland, der Eilrechtsschutz durch das BVerfG und der Rechtsschutz bei {\"u}berlangen Verfahren vor dem BVerfG in Deutschland.},
  language  = {de}
}
@article{Steinhorst2013,
  author    = {Steinhorst, Lars},
  title     = {Rechtsschutz bei {\"u}berlangen Gerichtsverfahren vor dem Bundesverfassungsgericht},
  series = {Verfassungsgerichtsbarkeit in der Russischen F{\"o}deration und in der Bundesrepublik Deutschland : Rundtischgespr{\"a}ch an der Moskauer Staatlichen Juristischen Kutafin-Universit{\"a}t am 9. und 10. Oktober 2012},
  journal   = {Verfassungsgerichtsbarkeit in der Russischen F{\"o}deration und in der Bundesrepublik Deutschland : Rundtischgespr{\"a}ch an der Moskauer Staatlichen Juristischen Kutafin-Universit{\"a}t am 9. und 10. Oktober 2012},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-68315},
  pages     = {93 -- 105},
  year      = {2013},
  abstract  = {Inhalt: I. Einleitung II. Einbeziehung des BVerfG und Sonderregelung f{\"u}r das verfassungsgerichtliche Verfahren III. Umfang und Voraussetzungen der Entsch{\"a}digungsleistung IV. Verfahren},
  language  = {de}
}
@article{SchaeferKakularamReischetal.2022,
  author    = {Sch{\"a}fer, Marj{\"a}nn Helena and Kakularam, Kumar Reddy and Reisch, Florian and Rothe, Michael and Stehling, Sabine and Heydeck, Dagmar and P{\"u}schel, Gerhard Paul and Kuhn, Hartmut},
  title     = {Male Knock-in Mice Expressing an Arachidonic Acid Lipoxygenase 15B (Alox15B) with Humanized Reaction Specificity Are Prematurely Growth Arrested When Aging},
  series = {Biomedicines},
  volume    = {10},
  journal   = {Biomedicines},
  edition   = {6},
  publisher = {MDPI},
  address   = {Basel, Schweiz},
  issn      = {2227-9059},
  doi       = {10.3390/biomedicines10061379},
  pages     = {1 -- 22},
  year      = {2022},
  abstract  = {Mammalian arachidonic acid lipoxygenases (ALOXs) have been implicated in cell differentiation and in the pathogenesis of inflammation. The mouse genome involves seven functional Alox genes and the encoded enzymes share a high degree of amino acid conservation with their human orthologs. There are, however, functional differences between mouse and human ALOX orthologs. Human ALOX15B oxygenates arachidonic acid exclusively to its 15-hydroperoxy derivative (15S-HpETE), whereas 8S-HpETE is dominantly formed by mouse Alox15b. The structural basis for this functional difference has been explored and in vitro mutagenesis humanized the reaction specificity of the mouse enzyme. To explore whether this mutagenesis strategy may also humanize the reaction specificity of mouse Alox15b in vivo, we created Alox15b knock-in mice expressing the arachidonic acid 15-lipoxygenating Tyr603Asp+His604Val double mutant instead of the 8-lipoxygenating wildtype enzyme. These mice are fertile, display slightly modified plasma oxylipidomes and develop normally up to an age of 24 weeks. At later developmental stages, male Alox15b-KI mice gain significantly less body weight than outbred wildtype controls, but this effect was not observed for female individuals. To explore the possible reasons for the observed gender-specific growth arrest, we determined the basic hematological parameters and found that aged male Alox15b-KI mice exhibited significantly attenuated red blood cell parameters (erythrocyte counts, hematocrit, hemoglobin). Here again, these differences were not observed in female individuals. These data suggest that humanization of the reaction specificity of mouse Alox15b impairs the functionality of the hematopoietic system in males, which is paralleled by a premature growth arrest.},
  language  = {en}
}
@article{Hoof2013,
  author    = {Hoof, Karsten},
  title     = {Eilrechtsschutz durch das Bundesverfassungsgericht},
  series = {Verfassungsgerichtsbarkeit in der Russischen F{\"o}deration und in der Bundesrepublik Deutschland : Rundtischgespr{\"a}ch an der Moskauer Staatlichen Juristischen Kutafin-Universit{\"a}t am 9. und 10. Oktober 2012},
  journal   = {Verfassungsgerichtsbarkeit in der Russischen F{\"o}deration und in der Bundesrepublik Deutschland : Rundtischgespr{\"a}ch an der Moskauer Staatlichen Juristischen Kutafin-Universit{\"a}t am 9. und 10. Oktober 2012},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-68300},
  pages     = {81 -- 91},
  year      = {2013},
  abstract  = {Inhalt: I. Sinn und Zweck II. Zul{\"a}ssigkeit III. Begr{\"u}ndetheit IV. Aus der Spruchpraxis des BVerfG V. Zusammenfassung},
  language  = {de}
}
@article{Mitjukov2013,
  author    = {Mitjukov, Mitjukov, Michail Alekseevič},
  title     = {Die Verfassungsgerichtsbarkeit in den Subjekten der Russischen F{\"o}deration},
  series = {Verfassungsgerichtsbarkeit in der Russischen F{\"o}deration und in der Bundesrepublik Deutschland : Rundtischgespr{\"a}ch an der Moskauer Staatlichen Juristischen Kutafin-Universit{\"a}t am 9. und 10. Oktober 2012},
  journal   = {Verfassungsgerichtsbarkeit in der Russischen F{\"o}deration und in der Bundesrepublik Deutschland : Rundtischgespr{\"a}ch an der Moskauer Staatlichen Juristischen Kutafin-Universit{\"a}t am 9. und 10. Oktober 2012},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-68254},
  pages     = {35 -- 44},
  year      = {2013},
  language  = {de}
}
@article{Narutto2013,
  author    = {Narutto, Svetlana Vasil'evna},
  title     = {Bestimmtheitsgrundsatz als Kriterium der Verfassungsm{\"a}ßigkeit der Gesetze},
  series = {Verfassungsgerichtsbarkeit in der Russischen F{\"o}deration und in der Bundesrepublik Deutschland : Rundtischgespr{\"a}ch an der Moskauer Staatlichen Juristischen Kutafin-Universit{\"a}t am 9. und 10. Oktober 2012},
  journal   = {Verfassungsgerichtsbarkeit in der Russischen F{\"o}deration und in der Bundesrepublik Deutschland : Rundtischgespr{\"a}ch an der Moskauer Staatlichen Juristischen Kutafin-Universit{\"a}t am 9. und 10. Oktober 2012},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-68338},
  pages     = {113 -- 120},
  year      = {2013},
  language  = {de}
}
@article{Michaleva2013,
  author    = {Michaleva, Nadezda A.},
  title     = {Der russische F{\"o}deralismus im Objektiv der Verfassungsrechtspflege},
  series = {Verfassungsgerichtsbarkeit in der Russischen F{\"o}deration und in der Bundesrepublik Deutschland : Rundtischgespr{\"a}ch an der Moskauer Staatlichen Juristischen Kutafin-Universit{\"a}t am 9. und 10. Oktober 2012},
  journal   = {Verfassungsgerichtsbarkeit in der Russischen F{\"o}deration und in der Bundesrepublik Deutschland : Rundtischgespr{\"a}ch an der Moskauer Staatlichen Juristischen Kutafin-Universit{\"a}t am 9. und 10. Oktober 2012},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-68344},
  pages     = {121 -- 128},
  year      = {2013},
  language  = {de}
}
@article{Yustus2013,
  author    = {Yustus, Ekaterina},
  title     = {Status und Aufgaben des Bundesverfassungsgerichts},
  series = {Verfassungsgerichtsbarkeit in der Russischen F{\"o}deration und in der Bundesrepublik Deutschland : Rundtischgespr{\"a}ch an der Moskauer Staatlichen Juristischen Kutafin-Universit{\"a}t am 9. und 10. Oktober 2012},
  journal   = {Verfassungsgerichtsbarkeit in der Russischen F{\"o}deration und in der Bundesrepublik Deutschland : Rundtischgespr{\"a}ch an der Moskauer Staatlichen Juristischen Kutafin-Universit{\"a}t am 9. und 10. Oktober 2012},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-68278},
  pages     = {57 -- 61},
  year      = {2013},
  abstract  = {Inhalt: I. Die verfassungsrechtliche Stellung des BVerfG II. Die Zusammensetzung des BVerfG III. Die Zus{\"a}ndigkeit des BVerfG},
  language  = {de}
}
@article{Postier2013,
  author    = {Postier, R{\"u}diger},
  title     = {Verfassungsgerichtsbarkeit im Land Brandenburg},
  series = {Verfassungsgerichtsbarkeit in der Russischen F{\"o}deration und in der Bundesrepublik Deutschland : Rundtischgespr{\"a}ch an der Moskauer Staatlichen Juristischen Kutafin-Universit{\"a}t am 9. und 10. Oktober 2012},
  journal   = {Verfassungsgerichtsbarkeit in der Russischen F{\"o}deration und in der Bundesrepublik Deutschland : Rundtischgespr{\"a}ch an der Moskauer Staatlichen Juristischen Kutafin-Universit{\"a}t am 9. und 10. Oktober 2012},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-68283},
  pages     = {63 -- 67},
  year      = {2013},
  abstract  = {Inhalt: I. Die Stellung des Verfassungsgerichts des Landes Brandenburgs im Staatsgef{\"u}ge II. Bildung und Zusammensetzung des Verfassungsgerichts III. Die Aufgaben des Verfassungsgerichts IV. Die Arbeitsweise des Verfassungsgerichts},
  language  = {de}
}