@book{OPUS4-56684,
  title     = {Drug target miRNA},
  series = {Methods in Molecular Biology},
  journal   = {Methods in Molecular Biology},
  editor    = {Schmidt, Marco F.},
  publisher = {Springer},
  address   = {New York},
  isbn      = {978-1-4939-6561-8},
  issn      = {1064-3745},
  doi       = {10.1007/978-1-4939-6563-2},
  pages     = {320},
  year      = {2017},
  abstract  = {This volume provides a concise and technical discussion of recently developed approaches to overcome challenges in miRNA drug discovery. Drug Target miRNA: Methods and Protocols explores strategies to overcome pharmacodynamics and pharmacokinetics challenges. These strategies cover anti-sense agents targeting miRNA that are applied in advanced formulations or are chemically optimized to increase delivery; small molecule miRNA modulators to overcome anti-sense agents' limitations; general enhancers of miRNA maturation; and Argonaute 2 protein and its pharmacokinetic parameters. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and thorough, Drug Target miRNA: Methods and Protocols is a valuable resource for anyone interested in the ever-evolving field of miRNA drug discovery.},
  language  = {en}
}