@book{OPUS4-56684, title = {Drug target miRNA}, series = {Methods in Molecular Biology}, journal = {Methods in Molecular Biology}, editor = {Schmidt, Marco F.}, publisher = {Springer}, address = {New York}, isbn = {978-1-4939-6561-8}, issn = {1064-3745}, doi = {10.1007/978-1-4939-6563-2}, pages = {320}, year = {2017}, abstract = {This volume provides a concise and technical discussion of recently developed approaches to overcome challenges in miRNA drug discovery. Drug Target miRNA: Methods and Protocols explores strategies to overcome pharmacodynamics and pharmacokinetics challenges. These strategies cover anti-sense agents targeting miRNA that are applied in advanced formulations or are chemically optimized to increase delivery; small molecule miRNA modulators to overcome anti-sense agents' limitations; general enhancers of miRNA maturation; and Argonaute 2 protein and its pharmacokinetic parameters. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and thorough, Drug Target miRNA: Methods and Protocols is a valuable resource for anyone interested in the ever-evolving field of miRNA drug discovery.}, language = {en} } @book{Koechy2006, author = {K{\"o}chy, Martin}, title = {Opposite trends in life stages of annual plants caused by daily rainfall variability - interaction with climate change}, year = {2006}, abstract = {Global Circulation Models of climate predict not only a change of annual precipitation amounts but also a shift in the daily distribution. To improve the understanding of the importance of daily rain pattern for annual plant communities, which represent a large portion of semi-natural vegetation in the Middle East, I used a detailed, spatially explicit model. The model explicitly considers water storage in the soil and has been parameterized and validated with data collected in field experiments in Israel and data from the literature. I manipulated daily rainfall variability by increasing the mean daily rain intensity on rainy days (MDI, rain volume/day) and decreasing intervals between rainy days while keeping the mean annual amount constant. In factorial combination, I also increased mean annual precipitation (MAP). I considered five climatic regions characterized by 100, 300, 450, 600, and 800 mm MAP. Increasing MDI decreased establishment when MAP was >250 mm but increased establishment at more arid sites. The negative effect of increasing MDI was compensated by increasing mortality with increasing MDI in dry and typical Mediterranean regions (c. 360-720 mm MAP). These effects were strongly tied to water availability in upper and lower soil layers and modified by competition among seedlings and adults. Increasing MAP generally increased water availability, establishment, and density. The order of magnitudes of MDI and MAP effects overlapped partially so that their combined effect is important for projections of climate change effects on annual vegetation. The effect size of MAP and MDI followed a sigmoid curve along the MAP gradient indicating that the semi-arid region (?300 mm MAP) is the most sensitive to precipitation change with regard to annual communities.}, language = {en} } @book{AbelHolschneider2009, author = {Abel, Markus and Holschneider, Matthias}, title = {Modellierung und Datenbankanalyse komplexer Systeme Teil 8 : Vorlesung 2009-06-25}, publisher = {Univ.-Bibl.}, address = {Potsdam}, year = {2009}, abstract = {Komplexe Systeme reichen von "harten", physikalischen, wie Klimaphysik, Turbulenz in Fluiden oder Plasmen bis zu so genannten "weichen", wie man sie in der Biologie, der Physik weicher Materie, Soziologie oder {\"O}konomie findet. Die Ausbildung von Verst{\"a}ndnis zu einem solchen System beinhaltet eine Beschreibung in Form von Statistiken und schlussendlich mathematischen Gleichungen. Moderne Datenanalyse stellt eine große Menge von Werkzeugen zur Analyse von Komplexit{\"a}t auf verschiedenen Beschreibungsebenen bereit. In diesem Kurs werden statistische Methoden mit einem Schwerpunkt auf dynamischen Systemen diskutiert und einge{\"u}bt. Auf der methodischen Seite werden lineare und nichtlineare Ans{\"a}tze behandelt, inklusive der Standard-Werkzeuge der deskriptiven und schlussfolgernden Statistik, Wavelet Analyse, Nichtparametrische Regression und der Sch{\"a}tzung nichtlinearer Maße wie fraktaler Dimensionen, Entropien und Komplexit{\"a}tsmaßen. Auf der Modellierungsseite werden deterministische und stochastische Systeme, Chaos, Skalierung und das Entstehen von Komplexit{\"a}t durch Wechselwirkung diskutiert - sowohl f{\"u}r diskrete als auch f{\"u}r ausgedehnte Systeme. Die beiden Ans{\"a}tze werden durch Systemanalyse jeweils passender Beispiele vereint.}, language = {de} } @book{GaedkeWickham2004, author = {Gaedke, Ursula and Wickham, Steve}, title = {Ciliate dynamics in response to changing biotic and abiotic conditions in a large, deep lake (L. Constance)}, issn = {0948-3055}, year = {2004}, abstract = {During 1987-1998, the ciliates and their prey and predator communities in large, deep, mesotrophic Lake Constance were intensively studied as it underwent re-oligotrophication. Ciliate biomass exhibited the bimodal seasonal distribution typical for meso-eutrophic lakes, with high biomass in spring and summer and low biomass in winter and during the clear-water phase. Cluster analysis produced nine groups of temporally co-occurring ciliate morphotypes with potentially similar ecological characteristics. The clusters exhibited a larger seasonality than found in the size distribution, showing that similarly-sized ciliates had seasonally compensatory dynamics. Ciliate biomass declined by approx. 30 \% during the 12 years of study, i.e. considerably less than daphnids (and total phosphorus). This yielded a significant increase in the ratio between summer ciliate and daphnid biomass as re-oligotrophication progressed, in contrast to previous studies. Few indications for a mechanistic link between phosphorus concentrations (which declined threefold during the study period) and ciliate biomass or community composition via group-specific food concentrations were found. The relative contribution of three of the nine clusters changed as re-oligotrophication progressed. Ciliate size distribution was related to reoligotrophication and daphnid biomass in summer. The smallest and largest ciliates gained in importance when daphnids decreased whereas large ciliates declined. Overall, summer daphnid biomas had a greater predictive power for attributes of the ciliate community than the other factors studied (phosphorus, prey biomass, copepod biomass). The extent of bottom-up and top-down control of ciliates appeared to be time and group specific. Overall, the ciliate community exhibited remarkably recurrent seasonal patterns despite major alternations in abiotic and biotic conditions.}, language = {en} } @book{GaedkeSeifriedAdrian2004, author = {Gaedke, Ursula and Seifried, Angelika and Adrian, Rita}, title = {Biomass size spectra and plankton diversity in a shallow eutrophic lake}, issn = {1434-2944}, year = {2004}, abstract = {Biomass size spectra collate structural and functional attributes of plankton communities enabling standardised temporal and cross-system comparisons and may be rapidly obtained by automated particle counters. To examine how differences in plankton communities from highly eutrophic and more oligotrophic lakes are reflected in size spectra, a three-year time series of biomass size spectra was established for polymictic, eutrophic Lake M{\"u}ggelsee, based on approximately weekly sampling and microscopic enumeration. The continuous but often bumpy size spectra reflected appropriately the seasonal and trophy-related variations in the plankton composition and growth conditions and the potential impact of daphnids on smaller plankton. We tested the hypothesis that more diverse plankton communities have smoother size spectra than impoverished ones. The spectra of L. M{\"u}ggelsee and other more less eutrophic lakes covaried roughly with the functional diversity in total plankton composition but were unrelated to taxonomical diversity within the phyto- or mesozooplankton. The slopes of the normalised size spectra of Lake M{\"u}ggelsee were generally more negative than -1, exhibited a recurrent seasonal pattern, and were strongly correlated with crustacean biomass. In contrast to less eutrophic systems, slopes could not be used to quantify energy fluxes within the foodweb due to highly variable algal P/B ratios and frequently bumpy size distributions. The latter indicated stronger deviations from the ideal concept of a steady energy flow along the size gradient than found in e. g. large, mesotrophic Lake Constance.}, language = {en} } @book{BurkartDierschkeHoelzeletal.2004, author = {Burkart, Michael and Dierschke, Hartmut and H{\"o}lzel, Norbert and Nowak, Bernd and Fartmann, Thomas}, title = {Molinio-Arrhenatheretea = Kulturgrasland und verwandte Vegetationstypen. Teil 2: Molinietalia}, series = {Synopsis der Pflanzengesellschaften Deutschlands}, volume = {9}, journal = {Synopsis der Pflanzengesellschaften Deutschlands}, publisher = {Selbstverl. der Floristisch-Soziologischen Arbeitsgemeinschaft}, address = {G{\"o}ttingen}, issn = {1433-8440}, pages = {103 S.}, year = {2004}, language = {de} } @book{SchulzOrgzallFreydanketal.2005, author = {Schulz, Burkhard and Orgzall, Ingo and Freydank, Anke-Christine and Chenggang, X{\"u}}, title = {Self-organization of substituted 1,3,4-oxadizazoles in the solid state and at surfaces}, year = {2005}, abstract = {Different aspects of the structure formation for a class of molecules containing the diphenyl-1,3,4-oxadiazole fragment are discussed. Starting from the bulk state with the ideal crystal lattice and the derivation of some common packing motifs the formation of liquid-crystalline states are described. This leads to the consideration of structures found in Langmuir-Blodgett films and those obtained by organic molecular beam deposition. These structures may again be compared to those for the bulk crystalline state. Common features as well as characteristic differences due to peculiarities of the individual molecular structures are discussed. (c) 2005 Elsevier B.V. All rights reserved}, language = {en} } @book{MuzikanteFonavsBrehmeretal.2005, author = {Muzikante, I. and Fonavs, E. and Brehmer, Ludwig and Stiller, Burkhard}, title = {Photoinuced phenomena in corona poled polar organic films}, year = {2005}, abstract = {Organic materials have received considerable attention because of their large dipole moments and optical nonlinearities. The optically induced switching of material properties is important for studying the optoelectronic effects including second harmonic generation. Organic materials for photonic applications contain chromophore dipole which consist of acceptor and donor groups bridged by a delocalized pi-electron system. Both theoretical and experimental data show a reversible highly dipolar photoinduced intra molecular charge transfer in betaine type molecules accompanied by change of the sign and the value of the dipole moment. The arrangement of polar molecules in films is studied both by atom force microscopy and surface potential measurements. To understand the photo response of these materials, their spectroscopic and electrical properties are studied. The morphology and photoinduced surface potential switching of the self-assembled monolayers and polymer films are investigated. (c) 2005 Elsevier B.V. All rights reserved}, language = {en} } @book{SmertenkoFenenkoBrehmeretal.2005, author = {Smertenko, P. and Fenenko, L. and Brehmer, Ludwig and Schrader, Sigurd}, title = {Differential approach to the study of integral characteristics in polymer films}, year = {2005}, abstract = {The differential approach is based on the determination of dimensionless differential slope, for instance, of current-voltage characteristics (IVC), I=f(V). This slope (a) is given by formula alpha=d(lgI)/d(lgV). With such definition the ranges of constancy of the a(V) dependency correspond to the part of IVC characterized by the power behaviour (I similar to V-alpha). The differential slope of alpha(V) dependency gamma = d(lg alpha)/dlgV determines the exponent behaviour of curve (I similar to exp {eV(y)/kT}). Processing by the differential approach of the investigated theoretical or experimental characteristics permits us to determine the peculiarity of charge flow mechanisms, temperature behaviour of conductivity, etc. The theoretical base and some applications of differential approach to the investigation of the current-voltage, temperature and degradation characteristics of the polyaniline and poly(p- phenilenevinilene) based structures have been shown. (c) 2005 Elsevier B.V. All rights reserved}, language = {en} } @book{BergstedtGroenkeMeincke1996, author = {Bergstedt, Christel and Gr{\"o}nke, Ottokar and Meincke, Irmtraut}, title = {Biologie : Lehrbuch f{\"u}r Sekundarstufe II ; Gymnasium, Gesamtschule ; Lehrerband mit Kopiervorlagen}, publisher = {Volk u. Wissen}, address = {Berlin}, isbn = {3-06-012155-9}, pages = {160 S.}, year = {1996}, language = {de} }