@misc{NorregaardMetzlerRitteretal.2017, author = {Norregaard, Kamilla and Metzler, Ralf and Ritter, Christine M. and Berg-Sorensen, Kirstine and Oddershede, Lene Broeng}, title = {Manipulation and Motion of Organelles and Single Molecules in Living Cells}, series = {Chemical reviews}, volume = {117}, journal = {Chemical reviews}, number = {5}, publisher = {American Chemical Society}, address = {Washington}, issn = {0009-2665}, doi = {10.1021/acs.chemrev.6b00638}, pages = {4342 -- 4375}, year = {2017}, abstract = {The biomolecule is among the most important building blocks of biological systems, and a full understanding of its function forms the scaffold for describing the mechanisms of higher order structures as organelles and cells. Force is a fundamental regulatory mechanism of biomolecular interactions driving many cellular processes. The forces on a molecular scale are exactly in the range that can be manipulated and probed with single molecule force spectroscopy. The natural environment of a biomolecule is inside a living cell, hence, this is the most relevant environment for probing their function. In vivo studies are, however, challenged by the complexity of the cell. In this review, we start with presenting relevant theoretical tools for analyzing single molecule data obtained in intracellular environments followed by a description of state-of-the art visualization techniques. The most commonly used force spectroscopy techniques, namely optical tweezers, magnetic tweezers, and atomic force microscopy, are described in detail, and their strength and limitations related to in vivo experiments are discussed. Finally, recent exciting discoveries within the field of in vivo manipulation and dynamics of single molecule and organelles are reviewed.}, language = {en} } @misc{BordeSmithSutherlandetal.2017, author = {Borde, Ron and Smith, Jordan J. and Sutherland, Rachel and Nathan, Nicole and Lubans, David Revalds}, title = {Methodological considerations and impact of school-based interventions on objectively measured physical activity in adolescents: a systematic review and meta-analysis}, series = {Obesity reviews : an official journal of the International Association for the Study of Obesity}, volume = {18}, journal = {Obesity reviews : an official journal of the International Association for the Study of Obesity}, publisher = {Wiley}, address = {Hoboken}, issn = {1467-7881}, doi = {10.1111/obr.12517}, pages = {476 -- 490}, year = {2017}, abstract = {Objective: The aims of this systematic review and meta-analysis are (i) to determine the impact of school-based interventions on objectively measured physical activity among adolescents and (ii) to examine accelerometer methods and decision rule reporting in previous interventions. Methods: A systematic search was performed to identify randomized controlled trials targeting adolescents (age: >= 10 years), conducted in the school setting, and reporting objectively measured physical activity. Random effects meta-analyses were conducted to determine the pooled effects of previous interventions on total and moderate-to-vigorous physical activity. Potential moderators of intervention effects were also explored. Results: Thirteen articles met the inclusion criteria, and twelve were included in the meta-analysis. The pooled effects were small and non-significant for both total physical activity (standardized mean difference = 0.02 [95\% confidence interval = -0.13 to 0.18]) and moderate-to-vigorous physical activity (standardized mean difference = 0.24 [95\% confidence interval = -0.08 to 0.56]). Sample age and accelerometer compliance were significant moderators for total physical activity, with a younger sample and higher compliance associated with larger effects. Conclusion: Previous school-based physical activity interventions targeting adolescents have been largely unsuccessful, particularly for older adolescents. There is a need for more high-quality research using objective monitoring in this population. Future interventions should comply with best-practice recommendations regarding physical activity monitoring protocols.}, language = {en} } @misc{MartinezNunezKretschmarBozzoetal.2017, author = {Martinez-Nunez, Silvia and Kretschmar, Peter and Bozzo, Enrico and Oskinova, Lida and Puls, Joachim and Sidoli, Lara and Sundqvist, Jon Olof and Blay, Pere and Falanga, Maurizio and Furst, Felix and Gimenez-Garcia, Angel and Kreykenbohm, Ingo and Kuehnel, Matthias and Sander, Andreas Alexander Christoph and Torrejon, Jose Miguel and Wilms, Joern}, title = {Towards a Unified View of Inhomogeneous Stellar Winds in Isolated Supergiant Stars and Supergiant High Mass X-Ray Binaries}, series = {Space science reviews}, volume = {212}, journal = {Space science reviews}, publisher = {Springer}, address = {Dordrecht}, issn = {0038-6308}, doi = {10.1007/s11214-017-0340-1}, pages = {59 -- 150}, year = {2017}, abstract = {Massive stars, at least similar to 10 times more massive than the Sun, have two key properties that make them the main drivers of evolution of star clusters, galaxies, and the Universe as a whole. On the one hand, the outer layers of massive stars are so hot that they produce most of the ionizing ultraviolet radiation of galaxies; in fact, the first massive stars helped to re-ionize the Universe after its Dark Ages. Another important property of massive stars are the strong stellar winds and outflows they produce. This mass loss, and finally the explosion of a massive star as a supernova or a gamma-ray burst, provide a significant input of mechanical and radiative energy into the interstellar space. These two properties together make massive stars one of the most important cosmic engines: they trigger the star formation and enrich the interstellar medium with heavy elements, that ultimately leads to formation of Earth-like rocky planets and the development of complex life. The study of massive star winds is thus a truly multidisciplinary field and has a wide impact on different areas of astronomy. In recent years observational and theoretical evidences have been growing that these winds are not smooth and homogeneous as previously assumed, but rather populated by dense "clumps". The presence of these structures dramatically affects the mass loss rates derived from the study of stellar winds. Clump properties in isolated stars are nowadays inferred mostly through indirect methods (i.e., spectroscopic observations of line profiles in various wavelength regimes, and their analysis based on tailored, inhomogeneous wind models). The limited characterization of the clump physical properties (mass, size) obtained so far have led to large uncertainties in the mass loss rates from massive stars. Such uncertainties limit our understanding of the role of massive star winds in galactic and cosmic evolution. Supergiant high mass X-ray binaries (SgXBs) are among the brightest X-ray sources in the sky. A large number of them consist of a neutron star accreting from the wind of a massive companion and producing a powerful X-ray source. The characteristics of the stellar wind together with the complex interactions between the compact object and the donor star determine the observed X-ray output from all these systems. Consequently, the use of SgXBs for studies of massive stars is only possible when the physics of the stellar winds, the compact objects, and accretion mechanisms are combined together and confronted with observations. This detailed review summarises the current knowledge on the theory and observations of winds from massive stars, as well as on observations and accretion processes in wind-fed high mass X-ray binaries. The aim is to combine in the near future all available theoretical diagnostics and observational measurements to achieve a unified picture of massive star winds in isolated objects and in binary systems.}, language = {en} } @misc{LaquaiAndrienkoDeibeletal.2017, author = {Laquai, Frederic and Andrienko, Denis and Deibel, Carsten and Neher, Dieter}, title = {Charge carrier generation, recombination, and extraction in polymer-fullerene bulk heterojunction organic solar cells}, series = {Elementary processes in organic photovoltaics}, volume = {272}, journal = {Elementary processes in organic photovoltaics}, publisher = {Springer}, address = {Berlin}, isbn = {978-3-319-28338-8}, issn = {0065-3195}, doi = {10.1007/978-3-319-28338-8_11}, pages = {267 -- 291}, year = {2017}, abstract = {In this chapter we review the basic principles of photocurrent generation in bulk heterojunction organic solar cells, discuss the loss channels limiting their efficiency, and present case studies of several polymer-fullerene blends. Using steady-state and transient, optical, and electrooptical techniques, we create a precise picture of the fundamental processes that ultimately govern solar cell efficiency.}, language = {en} } @misc{SadovnichiiPanasyukAmelyushkinetal.2017, author = {Sadovnichii, V. A. and Panasyuk, M. I. and Amelyushkin, A. M. and Bogomolov, V. V. and Benghin, V. V. and Garipov, G. K. and Kalegaev, V. V. and Klimov, P. A. and Khrenov, B. A. and Petrov, V. L. and Sharakin, S. A. and Shirokov, A. V. and Svertilov, S. I. and Zotov, M. Y. and Yashin, I. V. and Gorbovskoy, E. S. and Lipunov, V. M. and Park, I. H. and Lee, J. and Jeong, S. and Kim, M. B. and Jeong, H. M. and Shprits, Yuri Y. and Angelopoulos, V. and Russell, C. T. and Runov, A. and Turner, D. and Strangeway, R. J. and Caron, R. and Biktemerova, S. and Grinyuk, A. and Lavrova, M. and Tkachev, L. and Tkachenko, A. and Martinez, O. and Salazar, H. and Ponce, E.}, title = {"Lomonosov" Satellite-Space Observatory to Study Extreme Phenomena in Space}, series = {Space science reviews}, volume = {212}, journal = {Space science reviews}, publisher = {Springer}, address = {Dordrecht}, issn = {0038-6308}, doi = {10.1007/s11214-017-0425-x}, pages = {1705 -- 1738}, year = {2017}, abstract = {The "Lomonosov" space project is lead by Lomonosov Moscow State University in collaboration with the following key partners: Joint Institute for Nuclear Research, Russia, University of California, Los Angeles (USA), University of Pueblo (Mexico), Sungkyunkwan University (Republic of Korea) and with Russian space industry organi-zations to study some of extreme phenomena in space related to astrophysics, astroparticle physics, space physics, and space biology. The primary goals of this experiment are to study: -Ultra-high energy cosmic rays (UHECR) in the energy range of the Greizen-ZatsepinKuzmin (GZK) cutoff; -Ultraviolet (UV) transient luminous events in the upper atmosphere; -Multi-wavelength study of gamma-ray bursts in visible, UV, gamma, and X-rays; -Energetic trapped and precipitated radiation (electrons and protons) at low-Earth orbit (LEO) in connection with global geomagnetic disturbances; -Multicomponent radiation doses along the orbit of spacecraft under different geomagnetic conditions and testing of space segments of optical observations of space-debris and other space objects; -Instrumental vestibular-sensor conflict of zero-gravity phenomena during space flight. This paper is directed towards the general description of both scientific goals of the project and scientific equipment on board the satellite. The following papers of this issue are devoted to detailed descriptions of scientific instruments.}, language = {en} } @misc{ShpritsAngelopoulosRusselletal.2017, author = {Shprits, Yuri Y. and Angelopoulos, V. and Russell, C. T. and Strangeway, R. J. and Runov, A. and Turner, D. and Caron, R. and Cruce, P. and Leneman, D. and Michaelis, I. and Petrov, V. and Panasyuk, M. and Yashin, I. and Drozdov, Alexander and Russell, C. L. and Kalegaev, V. and Nazarkov, I. and Clemmons, J. H.}, title = {Scientific Objectives of Electron Losses and Fields INvestigation Onboard Lomonosov Satellite}, series = {Space science reviews}, volume = {214}, journal = {Space science reviews}, number = {1}, publisher = {Springer}, address = {Dordrecht}, issn = {0038-6308}, doi = {10.1007/s11214-017-0455-4}, pages = {19}, year = {2017}, abstract = {The objective of the Electron Losses and Fields INvestigation on board the Lomonosov satellite ( ELFIN-L) project is to determine the energy spectrum of precipitating energetic electrons and ions and, together with other polar-orbiting and equatorial missions, to better understand the mechanisms responsible for scattering these particles into the atmosphere. This mission will provide detailed measurements of the radiation environment at low altitudes. The 400-500 km sun-synchronous orbit of Lomonosov is ideal for observing electrons and ions precipitating into the atmosphere. This mission provides a unique opportunity to test the instruments. Similar suite of instruments will be flown in the future NSF-and NASA-supported spinning CubeSat ELFIN satellites which will augment current measurements by providing detailed information on pitch-angle distributions of precipitating and trapped particles.}, language = {en} }