@misc{MacGroganMuenchdelaPompa2018,
  author    = {MacGrogan, Donal and M{\"u}nch, Juliane and de la Pompa, Jos{\´e} Luis},
  title     = {Notch and interacting signalling pathways in cardiac development, disease, and regeneration},
  series = {Nature Reviews Cardiology},
  volume    = {15},
  journal   = {Nature Reviews Cardiology},
  number    = {11},
  publisher = {Nature Publ. Group},
  address   = {New York},
  issn      = {1759-5002},
  doi       = {10.1038/s41569-018-0100-2},
  pages     = {685 -- 704},
  year      = {2018},
  abstract  = {Cardiogenesis is a complex developmental process involving multiple overlapping stages of cell fate specification, proliferation, differentiation, and morphogenesis. Precise spatiotemporal coordination between the different cardiogenic processes is ensured by intercellular signalling crosstalk and tissue-tissue interactions. Notch is an intercellular signalling pathway crucial for cell fate decisions during multicellular organismal development and is aptly positioned to coordinate the complex signalling crosstalk required for progressive cell lineage restriction during cardiogenesis. In this Review, we describe the role of Notch signalling and the crosstalk with other signalling pathways during the differentiation and patterning of the different cardiac tissues and in cardiac valve and ventricular chamber development. We examine how perturbation of Notch signalling activity is linked to congenital heart diseases affecting the neonate and adult, and discuss studies that shed light on the role of Notch signalling in heart regeneration and repair after injury.},
  language  = {en}
}
@article{AndresDelgadoErnstGalardiCastillaetal.2019,
  author    = {Andr{\´e}s-Delgado, Laura and Ernst, Alexander and Galardi-Castilla, Mar{\´i}a and Bazaga, David and Peralta, Marina and M{\"u}nch, Juliane and Gonzalez-Rosa, Juan M. and Marques, In{\^e}s and Tessadori, Federico and de la Pompa, Jos{\´e} Luis and Vermot, Julien and Mercader, Nadia},
  title     = {Actin dynamics and the Bmp pathway drive apical extrusion of proepicardial cells},
  series = {Development : Company of Biologists},
  volume    = {146},
  journal   = {Development : Company of Biologists},
  number    = {13},
  publisher = {The Company of Biologists Ltd},
  address   = {Cambridge},
  issn      = {0950-1991},
  doi       = {10.1242/dev.174961},
  pages     = {15},
  year      = {2019},
  abstract  = {The epicardium, the outer mesothelial layer enclosing the myocardium, plays key roles in heart development and regeneration. During embryogenesis, the epicardium arises from the proepicardium (PE), a cell cluster that appears in the dorsal pericardium (DP) close to the venous pole of the heart. Little is known about how the PE emerges from the pericardial mesothelium. Using a zebrafish model and a combination of genetic tools, pharmacological agents and quantitative in vivo imaging, we reveal that a coordinated collective movement of DP cells drives PE formation. We found that Bmp signaling and the actomyosin cytoskeleton promote constriction of the DP, which enables PE cells to extrude apically. We provide evidence that cell extrusion, which has been described in the elimination of unfit cells from epithelia and the emergence of hematopoietic stem cells, is also a mechanism for PE cells to exit an organized mesothelium and fulfil their developmental fate to form a new tissue layer, the epicardium.},
  language  = {en}
}
@article{MuenchGrivasGonzalezRajaletal.2017,
  author    = {Muench, Juliane and Grivas, Dimitrios and Gonzalez-Rajal, Alvaro and Torregrosa-Carrion, Rebeca and de la Pompa, Jos{\´e} Luis},
  title     = {Notch signalling restricts inflammation and serpine1 expression in the dynamic endocardium of the regenerating zebrafish heart},
  series = {Development : Company of Biologists},
  volume    = {144},
  journal   = {Development : Company of Biologists},
  publisher = {Company of Biologists Limited},
  address   = {Cambridge},
  issn      = {0950-1991},
  doi       = {10.1242/dev.143362},
  pages     = {1425 -- 1440},
  year      = {2017},
  abstract  = {The zebrafish heart regenerates after ventricular damage through a process involving inflammation, fibrotic tissue deposition/removal and myocardial regeneration. Using 3D whole-mount imaging, we reveal a highly dynamic endocardium during cardiac regeneration, including changes in cell morphology, behaviour and gene expression. These events lay the foundation for an initial expansion of the endocardium that matures to form a coherent endocardial structure within the injury site. We studied two important endocardial molecules, Serpine1 and Notch, which are implicated in different aspects of endocardial regeneration. Notch signalling regulates developmental gene expression and features of endocardial maturation. Also, Notch manipulation interferes with attenuation of the inflammatory response and cardiomyocyte proliferation and dedifferentiation. serpine1 is strongly expressed very early in the wound endocardium, with decreasing expression at later time points. serpine1 expression persists in Notch-abrogated hearts, via what appears to be a conserved mechanism. Functional inhibition studies show that Serpine1 controls endocardial maturation and proliferation and cardiomyocyte proliferation. Thus, we describe a highly dynamic endocardium in the regenerating zebrafish heart, with two key endocardial players, Serpine1 and Notch signalling, regulating crucial regenerative processes.},
  language  = {en}
}