@article{ZimmermannDeVeaughGeissToennisetal.2020, author = {Zimmermann, Malte and De Veaugh-Geiss, Joseph P. and T{\"o}nnis, Swantje and Onea, Edgar}, title = {(Non-)exhaustivity in focus partitioning across languages}, series = {Approaches to Hungarian}, volume = {16}, journal = {Approaches to Hungarian}, publisher = {John Benjamins}, address = {Amsterdam}, pages = {24}, year = {2020}, abstract = {We present novel experimental evidence on the availability and the status of exhaustivity inferences with focus partitioning in German, English, and Hungarian. Results suggest that German and English focus-background clefts and Hungarian focus share important properties, ({\´E}. Kiss 1998, 1999; Szabolcsi 1994; Percus 1997; Onea \& Beaver 2009). Those constructions are anaphoric devices triggering an existence presupposition. EXH-inferences are not obligatory in such constructions in English, German, or Hungarian, against some previous literature (Percus 1997; B{\"u}ring \& Križ 2013; {\´E}. Kiss 1998), but in line with pragmatic analyses of EXH-inferences in clefts (Horn 1981, 2016; Pollard \& Yasavul 2016). The cross-linguistic differences in the distribution of EXH-inferences are attributed to properties of the Hungarian number marking system.}, language = {en} } @article{ZimmermannRegiererKossmannetal.2004, author = {Zimmermann, P. and Regierer, Babette and Kossmann, Jens and Frossard, Emmanuel and Amrhein, Nikolaus and Bucher, Matthias}, title = {Differential expression of three purple acid phosphatases from potato}, issn = {1435-8603}, year = {2004}, abstract = {Three cDNAs encoding purple acid phosphatase (PAP) were cloned from potato (Solanum tuberosum L. cv. Desiree) and expression of the corresponding genes was characterised. StPAP1 encodes a low-molecular weight PAP clustering with mammalian, cyanobacterial, and other plant PAPs. It was highly expressed in stem and root and its expression did not change in response to phosphorus (P) deprivation. StIPAP2 and StPAP3 code for high-molecular weight PAPs typical for plants. Corresponding gene expression was shown to be responsive to the level of P supply, with transcripts of StPAP2 and StPAP3 being most abundant in P-deprived roots or both stem and roots, respectively. Root colonisation by arbuscular mycorrhizal fungi had no effect on the expression of any of the three PAP genes. StIPAP1 mRNA is easily detectable along the root axis, including root hairs, but is barely detectable in root tips. In contrast, both StPAP2 and StPAP3 transcripts are abundant along the root axis, but absent in root hairs, and are most abundant in the root tip. All three PAPs described contain a predicted N-terminal secretion signal and could play a role in extracellular P scavenging, P mobilisation from the rhizosphere, or cell wall regeneration}, language = {en} } @article{WeberOesterheltGrossetal.2004, author = {Weber, Andreas P. M. and Oesterhelt, Christine and Gross, Wolfgang and Br{\"a}utigam, Andrea and Imboden, Lori and Krassovskaya, Inga and Linka, Nicole and Truchina, Julia and Schneidereit, J{\"o}rg and Voll, Lars and Zimmermann, Marc and Jamai, Aziz and Riekhof, Wayne and Yu, Bin and Garavito, Michael R. and Benning, Christoph}, title = {EST-analysis of the thermo-acidophilic red microalga Galdieria sulphuraria reveals potential for lipid A biosynthesis and unveils the pathway of carbon export from rhodoplasts}, year = {2004}, abstract = {When we think of extremophiles, organisms adapted to extreme environments, prokaryotes come to mind first. However, the unicellular red micro-alga Galdieria sulphuraria (Cyanidiales) is a eukaryote that can represent up to 90\% of the biomass in extreme habitats such as hot sulfur springs with pH values of 0-4 and temperatures of up to 56 degreesC. This red alga thrives autotrophically as well as heterotrophically on more than 50 different carbon sources, including a number of rare sugars and sugar alcohols. This biochemical versatility suggests a large repertoire of metabolic enzymes, rivaled by few organisms and a potentially rich source of thermo-stable enzymes for biotechnology. The temperatures under which this organism carries out photosynthesis are at the high end of the range for this process, making G. sulphuraria a valuable model for physical studies on the photosynthetic apparatus. In addition, the gene sequences of this living fossil reveal much about the evolution of modern eukaryotes. Finally, the alga tolerates high concentrations of toxic metal ions such as cadmium, mercury, aluminum, and nickel, suggesting potential application in bioremediation. To begin to explore the unique biology of G. sulphuraria, 5270 expressed sequence tags from two different cDNA libraries have been sequenced and annotated. Particular emphasis has been placed on the reconstruction of metabolic pathways present in this organism. For example, we provide evidence for (i) a complete pathway for lipid A biosynthesis; (ii) export of triose-phosphates from rhodoplasts; (iii) and absence of eukaryotic hexokinases. Sequence data and additional information are available at http://genomics.msu.edu/galdieria}, language = {en} } @article{DeVeaughGeissToennisOneaetal.2018, author = {De Veaugh-Geiss, Joseph P. and Toennis, Swantje and Onea, Edgar and Zimmermann, Malte}, title = {That's not quite it}, series = {Semantics and pragmatics}, volume = {11}, journal = {Semantics and pragmatics}, publisher = {Linguistic Society of America}, address = {Washington}, issn = {1937-8912}, doi = {10.3765/sp.11.3}, pages = {44}, year = {2018}, abstract = {We present a novel empirical study on German directly comparing the exhaustivity inference in es-clefts to exhaustivity inferences in definite pseudoclefts, exclusives, and plain intonational focus constructions. We employ mouse-driven verification/falsification tasks in an incremental information-retrieval paradigm across two experiments in order to assess the strength of exhaustivity in the four sentence types. The results are compatible with a parallel analysis of clefts and definite pseudoclefts, in line with previous claims in the literature (Percus 1997, Buring \& Kriz 2013). In striking contrast with such proposals, in which the exhaustivity inference is conventionally coded in the cleft-structure in terms of maximality/homogeneity, our study found that the exhaustivity inference is not systematic or robust in es-clefts nor in definite pseudoclefts: Whereas some speakers treat both constructions as exhaustive, others treat both constructions as non-exhaustive. In order to account for this unexpected finding, we argue that the exhaustivity inference in both clefts and definite pseudoclefts-specifically those with the compound definite derjenige - is pragmatically derived from the anaphoric existence presupposition that is common to both constructions.}, language = {en} } @misc{ZimmermannDeVeaughGeissToennisetal.2020, author = {Zimmermann, Malte and De Veaugh-Geiss, Joseph P. and T{\"o}nnis, Swantje and Onea, Edgar}, title = {(Non-)exhaustivity in focus partitioning across languages}, series = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe}, volume = {16}, journal = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe}, issn = {1866-8364}, doi = {10.25932/publishup-52467}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-524677}, pages = {26}, year = {2020}, abstract = {We present novel experimental evidence on the availability and the status of exhaustivity inferences with focus partitioning in German, English, and Hungarian. Results suggest that German and English focus-background clefts and Hungarian focus share important properties, ({\´E}. Kiss 1998, 1999; Szabolcsi 1994; Percus 1997; Onea \& Beaver 2009). Those constructions are anaphoric devices triggering an existence presupposition. EXH-inferences are not obligatory in such constructions in English, German, or Hungarian, against some previous literature (Percus 1997; B{\"u}ring \& Križ 2013; {\´E}. Kiss 1998), but in line with pragmatic analyses of EXH-inferences in clefts (Horn 1981, 2016; Pollard \& Yasavul 2016). The cross-linguistic differences in the distribution of EXH-inferences are attributed to properties of the Hungarian number marking system.}, language = {en} } @article{GronkeHernandezZimmermannetal.2019, author = {Gronke, Konrad and Hernandez, Pedro P. and Zimmermann, Jakob and Klose, Christoph S. N. and Kofoed-Branzk, Michael and Guendel, Fabian and Witkowski, Mario and Tizian, Caroline and Amann, Lukas and Schumacher, Fabian and Glatt, Hansruedi and Triantafyllopoulou, Antigoni and Diefenbach, Andreas}, title = {Interleukin-22 protects intestinal stem cells against genotoxic stress}, series = {Nature : the international weekly journal of science}, volume = {566}, journal = {Nature : the international weekly journal of science}, number = {7743}, publisher = {Nature Publ. Group}, address = {London}, issn = {0028-0836}, doi = {10.1038/s41586-019-0899-7}, pages = {249 -- 253}, year = {2019}, abstract = {Environmental genotoxic factors pose a challenge to the genomic integrity of epithelial cells at barrier surfaces that separate host organisms from the environment. They can induce mutations that, if they occur in epithelial stem cells, contribute to malignant transformation and cancer development1,2,3. Genome integrity in epithelial stem cells is maintained by an evolutionarily conserved cellular response pathway, the DNA damage response (DDR). The DDR culminates in either transient cell-cycle arrest and DNA repair or elimination of damaged cells by apoptosis4,5. Here we show that the cytokine interleukin-22 (IL-22), produced by group 3 innate lymphoid cells (ILC3) and γδ T cells, is an important regulator of the DDR machinery in intestinal epithelial stem cells. Using a new mouse model that enables sporadic inactivation of the IL-22 receptor in colon epithelial stem cells, we demonstrate that IL-22 is required for effective initiation of the DDR following DNA damage. Stem cells deprived of IL-22 signals and exposed to carcinogens escaped DDR-controlled apoptosis, contained more mutations and were more likely to give rise to colon cancer. We identified metabolites of glucosinolates, a group of phytochemicals contained in cruciferous vegetables, to be a widespread source of genotoxic stress in intestinal epithelial cells. These metabolites are ligands of the aryl hydrocarbon receptor (AhR)6, and AhR-mediated signalling in ILC3 and γδ T cells controlled their production of IL-22. Mice fed with diets depleted of glucosinolates produced only very low levels of IL-22 and, consequently, the DDR in epithelial cells of mice on a glucosinolate-free diet was impaired. This work identifies a homeostatic network protecting stem cells against challenge to their genome integrity by AhR-mediated 'sensing' of genotoxic compounds from the diet. AhR signalling, in turn, ensures on-demand production of IL-22 by innate lymphocytes directly regulating components of the DDR in epithelial stem cells.}, language = {en} } @article{GuentherSchueleZurelletal.2023, author = {G{\"u}nther, Oliver and Sch{\"u}le, Manja and Zurell, Damaris and Jeltsch, Florian and Roeleke, Manuel and Kampe, Heike and Zimmermann, Matthias and Scholz, Jana and Engbert, Ralf and Elsner, Birgit and Schlangen, David and Agrofylax, Luisa and Georgi, Doreen and Weymar, Mathias and Wagener, Thorsten and Bookhagen, Bodo and Eibl, Eva P. S. and Korup, Oliver and Oswald, Sascha and Thieken, Annegret and van der Beek, Pieter A.}, title = {Portal Wissen = Exzellenz}, series = {Portal Wissen: Das Forschungsmagazin der Universit{\"a}t Potsdam}, journal = {Portal Wissen: Das Forschungsmagazin der Universit{\"a}t Potsdam}, number = {02/2023}, issn = {2194-4245}, doi = {10.25932/publishup-61144}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-611440}, pages = {98}, year = {2023}, abstract = {Was nicht nur gut oder sehr gut ist, nennen wir gern exzellent. Aber was meint das eigentlich? Vom lateinischen „excellere" kommend, beschreibt es Dinge, Personen oder Handlungen, die „hervor-" oder „herausragen" aus der Menge, sich „auszeichnen" gegen{\"u}ber anderen. Mehr geht nicht. Exzellenz ist das Mittel der Wahl, wenn es darum geht, der Erste oder Beste zu sein. Und das macht auch vor der Forschung nicht halt. Wer auf die Universit{\"a}t Potsdam schaut, findet zahlreiche ausgezeichnete Forschende, hervorragende Projekte und immer wieder auch aufsehenerregende Erkenntnisse, Ver{\"o}ffentlichungen und Ergebnisse. Aber ist die UP auch exzellent? Eine Frage, die 2023 ganz sicher andere Wellen schl{\"a}gt als vielleicht vor 20 Jahren. Denn seit dem Start der Exzellenzinitiative 2005 gelten als - w{\"o}rtlich - exzellent jene Hochschulen, denen es gelingt, in dem umfangreichsten F{\"o}rderprogramm f{\"u}r Wissenschaft in Deutschland einen Zuschlag zu erhalten. Egal ob in Form von Graduiertenschulen, Forschungsclustern oder - seit Fortsetzung des Programms ab 2019 unter dem Titel „Exzellenzstrategie" - ganzen Exzellenzuniversit{\"a}ten: Wer im Kreis der Forschungsuniversit{\"a}ten zu den Besten geh{\"o}ren will, braucht das Siegel der Exzellenz. In der gerade eingel{\"a}uteten neuen Wettbewerbsrunde der „Exzellenzstrategie des Bundes und der L{\"a}nder" bewirbt sich die Universit{\"a}t Potsdam mit drei Clusterskizzen um F{\"o}rderung. Ein Antrag kommt aus der {\"O}kologie- und Biodiversit{\"a}tsforschung. Ziel ist es, ein komplexes Bild {\"o}kologischer Prozesse zu zeichnen - und dabei die Rolle von einzelnen Individuen ebenso zu betrachten wie das Zusammenwirken vieler Arten in einem {\"O}kosystem, um die Funktion der Artenvielfalt genauer zu bestimmen. Eine zweite Skizze haben die Kognitionswissenschaften eingereicht. Hier soll das komplexe Nebeneinander von Sprache und Kognition, Entwicklung und Lernen sowie Motivation und Verhalten als dynamisches Miteinander erforscht werden - wobei auch mit den Erziehungswissenschaften kooperiert wird, um verkn{\"u}pfte Lernund Bildungsprozesse stets mitzudenken. Der dritte Antrag aus den Geo- und Umweltwissenschaften nimmt extreme und besonders folgenschwere Naturgefahren und -prozesse wie {\"U}berschwemmungen und D{\"u}rren in den Blick. Die Forschenden untersuchen die Extremereignisse mit besonderem Fokus auf deren Wechselwirkung mit der Gesellschaft, um mit ihnen einhergehende Risiken und Sch{\"a}den besser einsch{\"a}tzen sowie k{\"u}nftig rechtzeitig Maßnahmen einleiten zu k{\"o}nnen. „Alle drei Antr{\"a}ge zeichnen ein hervorragendes Bild unserer Leistungsf{\"a}higkeit", betont der Pr{\"a}sident der Universit{\"a}t, Prof. Oliver G{\"u}nther, Ph.D. „Die Skizzen dokumentieren eindrucksvoll unser Engagement, vorhandene Forschungsexzellenz sowie die Potenziale der Universit{\"a}t Potsdam insgesamt. Allein die Tatsache, dass sich drei schlagkr{\"a}ftige Konsortien in ganz unterschiedlichen Themenbereichen zusammengefunden haben, zeigt, dass wir auf unserem Weg in die Spitzengruppe der deutschen Universit{\"a}ten einen guten Schritt vorangekommen sind." In diesem Heft schauen wir, was sich in und hinter diesen Antr{\"a}gen verbirgt: Wir haben mit den Wissenschaftlerinnen und Wissenschaftlern gesprochen, die sie geschrieben haben, und sie gefragt, was sie sich vornehmen, sollten sie den Zuschlag erhalten und ein Cluster an die Universit{\"a}t holen. Wir haben aber auch auf die Forschung geschaut, die zu den Antr{\"a}gen gef{\"u}hrt hat und die schon l{\"a}nger das Profil der Universit{\"a}t pr{\"a}gt und ihr national wie international Anerkennung eingebracht hat. Wir stellen eine kleine Auswahl an Projekten, Methoden und Forschenden vor, um zu zeigen, warum in diesen Antr{\"a}gen tats{\"a}chlich exzellente Forschung steckt! {\"U}brigens: Auch „Exzellenz" ist nicht das Ende der Fahnenstange. Immerhin l{\"a}sst sich das Adjektiv exzellent sogar steigern. In diesem Sinne w{\"u}nschen wir exzellentestes Vergn{\"u}gen beim Lesen!}, language = {de} } @article{GuentherSchueleZurelletal.2023, author = {G{\"u}nther, Oliver and Sch{\"u}le, Manja and Zurell, Damaris and Jeltsch, Florian and Roeleke, Manuel and Kampe, Heike and Zimmermann, Matthias and Scholz, Jana and Mikulla, Stefanie and Engbert, Ralf and Elsner, Birgit and Schlangen, David and Agrofylax, Luisa and Georgi, Doreen and Weymar, Mathias and Wagener, Thorsten and Bookhagen, Bodo and Eibl, Eva P. S. and Korup, Oliver and Oswald, Sascha and Thieken, Annegret and van der Beek, Pieter A.}, title = {Portal Wissen = Excellence}, series = {Portal Wissen: The research magazine of the University of Potsdam}, journal = {Portal Wissen: The research magazine of the University of Potsdam}, number = {02/2023}, issn = {2198-9974}, doi = {10.25932/publishup-61145}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-611456}, pages = {58}, year = {2023}, abstract = {When something is not just good or very good, we often call it excellent. But what does that really mean? Coming from the Latin word "excellere," it describes things, persons, or actions that are outstanding or superior and distinguish themselves from others. It cannot get any better. Excellence is the top choice for being the first or the best. Research is no exception. At the university, you will find numerous exceptional researchers, outstanding projects, and, time and again, sensational findings, publications, and results. But is the University of Potsdam also excellent? A question that will certainly create a different stir in 2023 than it did perhaps 20 years ago. Since the launch of the Excellence Initiative in 2005, universities that succeed in winning the most comprehensive funding program for research in Germany have been considered - literally - excellent. Whether in the form of graduate schools, research clusters, or - since the program was continued in 2019 under the title "Excellence Strategy" - entire universities of excellence: Anyone who wants to be among the best research universities needs the seal of excellence. The University of Potsdam is applying for funding with three cluster proposals in the recently launched new round of the "Excellence Strategy of the German Federal and State Governments." One proposal comes from ecology and biodiversity research. The aim is to paint a comprehensive picture of ecological processes by examining the role of single individuals as well as the interactions among many species in an ecosystem to precisely determine the function of biodiversity. A second proposal has been submitted by the cognitive sciences. Here, the complex coexistence of language and cognition, development and learning, as well as motivation and behavior will be researched as a dynamic interrelation. The projects will include cooperation with the educational sciences to constantly consider linked learning and educational processes. The third proposal from the geo and environmental sciences concentrates on extreme and particularly devastating natural hazards and processes such as floods and droughts. The researchers examine these extreme events, focusing on their interaction with society, to be able to better assess the risks and damages they might involve and to initiate timely measures in the future. "All three proposals highlight the excellence of our performance," emphasizes University President Prof. Oliver G{\"u}nther, Ph.D. "The outlines impressively document our commitment, existing research excellence, and the potential of the University of Potsdam as a whole. The fact that three powerful consortia have come together in different subject areas shows that we have taken a good step forward on our way to becoming one of the top German universities." In this issue, we are looking at what is in and behind these proposals: We talked to the researchers who wrote them. We asked them about their plans in case their proposals are successful and they bring a cluster of excellence to the university. But we also looked at the research that has led to the proposals, has long shaped the university's profile, and earned it national and international recognition. We present a small selection of projects, methods, and researchers to illustrate why there really is excellent research in these proposals! By the way, "excellence" is also not the end of the flagpole. After all, the adjective "excellent" even has a comparative and a superlative. With this in mind, I wish you the most excellent pleasure reading this issue!}, language = {en} } @article{GarbusowSchadSeboldetal.2016, author = {Garbusow, Maria and Schad, Daniel and Sebold, Miriam and Friedel, Eva and Bernhardt, Nadine and Koch, Stefan P. and Steinacher, Bruno and Kathmann, Norbert and Geurts, Dirk E. M. and Sommer, Christian and Mueller, Dirk K. and Nebe, Stephan and Paul, Soeren and Wittchen, Hans-Ulrich and Zimmermann, Ulrich S. and Walter, Henrik and Smolka, Michael N. and Sterzer, Philipp and Rapp, Michael A. and Huys, Quentin J. M. and Schlagenhauf, Florian and Heinz, Andreas}, title = {Pavlovian-to-instrumental transfer effects in the nucleus accumbens relate to relapse in alcohol dependence}, series = {Addiction biology}, volume = {21}, journal = {Addiction biology}, publisher = {Wiley-Blackwell}, address = {Hoboken}, issn = {1355-6215}, doi = {10.1111/adb.12243}, pages = {719 -- 731}, year = {2016}, abstract = {In detoxified alcohol-dependent patients, alcohol-related stimuli can promote relapse. However, to date, the mechanisms by which contextual stimuli promote relapse have not been elucidated in detail. One hypothesis is that such contextual stimuli directly stimulate the motivation to drink via associated brain regions like the ventral striatum and thus promote alcohol seeking, intake and relapse. Pavlovian-to-Instrumental-Transfer (PIT) may be one of those behavioral phenomena contributing to relapse, capturing how Pavlovian conditioned (contextual) cues determine instrumental behavior (e.g. alcohol seeking and intake). We used a PIT paradigm during functional magnetic resonance imaging to examine the effects of classically conditioned Pavlovian stimuli on instrumental choices in n=31 detoxified patients diagnosed with alcohol dependence and n=24 healthy controls matched for age and gender. Patients were followed up over a period of 3 months. We observed that (1) there was a significant behavioral PIT effect for all participants, which was significantly more pronounced in alcohol-dependent patients; (2) PIT was significantly associated with blood oxygen level-dependent (BOLD) signals in the nucleus accumbens (NAcc) in subsequent relapsers only; and (3) PIT-related NAcc activation was associated with, and predictive of, critical outcomes (amount of alcohol intake and relapse during a 3 months follow-up period) in alcohol-dependent patients. These observations show for the first time that PIT-related BOLD signals, as a measure of the influence of Pavlovian cues on instrumental behavior, predict alcohol intake and relapse in alcohol dependence.}, language = {en} }