@article{ReadKegelKluteetal.2013,
  author    = {Read, Betsy A. and Kegel, Jessica and Klute, Mary J. and Kuo, Alan and Lefebvre, Stephane C. and Maumus, Florian and Mayer, Christoph and Miller, John and Monier, Adam and Salamov, Asaf and Young, Jeremy and Aguilar, Maria and Claverie, Jean-Michel and Frickenhaus, Stephan and Gonzalez, Karina and Herman, Emily K. and Lin, Yao-Cheng and Napier, Johnathan and Ogata, Hiroyuki and Sarno, Analissa F. and Shmutz, Jeremy and Schroeder, Declan and de Vargas, Colomban and Verret, Frederic and von Dassow, Peter and Valentin, Klaus and Van de Peer, Yves and Wheeler, Glen and Dacks, Joel B. and Delwiche, Charles F. and Dyhrman, Sonya T. and Gl{\"o}ckner, Gernot and John, Uwe and Richards, Thomas and Worden, Alexandra Z. and Zhang, Xiaoyu and Grigoriev, Igor V. and Allen, Andrew E. and Bidle, Kay and Borodovsky, M. and Bowler, C. and Brownlee, Colin and Cock, J. Mark and Elias, Marek and Gladyshev, Vadim N. and Groth, Marco and Guda, Chittibabu and Hadaegh, Ahmad and Iglesias-Rodriguez, Maria Debora and Jenkins, J. and Jones, Bethan M. and Lawson, Tracy and Leese, Florian and Lindquist, Erika and Lobanov, Alexei and Lomsadze, Alexandre and Malik, Shehre-Banoo and Marsh, Mary E. and Mackinder, Luke and Mock, Thomas and M{\"u}ller-R{\"o}ber, Bernd and Pagarete, Antonio and Parker, Micaela and Probert, Ian and Quesneville, Hadi and Raines, Christine and Rensing, Stefan A. and Riano-Pachon, Diego Mauricio and Richier, Sophie and Rokitta, Sebastian and Shiraiwa, Yoshihiro and Soanes, Darren M. and van der Giezen, Mark and Wahlund, Thomas M. and Williams, Bryony and Wilson, Willie and Wolfe, Gordon and Wurch, Louie L.},
  title     = {Pan genome of the phytoplankton Emiliania underpins its global distribution},
  series = {Nature : the international weekly journal of science},
  volume    = {499},
  journal   = {Nature : the international weekly journal of science},
  number    = {7457},
  publisher = {Nature Publ. Group},
  address   = {London},
  organization    = {Emiliania Huxleyi Annotation},
  issn      = {0028-0836},
  doi       = {10.1038/nature12221},
  pages     = {209 -- 213},
  year      = {2013},
  abstract  = {Coccolithophores have influenced the global climate for over 200 million years(1). These marine phytoplankton can account for 20 per cent of total carbon fixation in some systems(2). They form blooms that can occupy hundreds of thousands of square kilometres and are distinguished by their elegantly sculpted calcium carbonate exoskeletons (coccoliths), rendering them visible from space(3). Although coccolithophores export carbon in the form of organic matter and calcite to the sea floor, they also release CO2 in the calcification process. Hence, they have a complex influence on the carbon cycle, driving either CO2 production or uptake, sequestration and export to the deep ocean(4). Here we report the first haptophyte reference genome, from the coccolithophore Emiliania huxleyi strain CCMP1516, and sequences from 13 additional isolates. Our analyses reveal a pan genome (core genes plus genes distributed variably between strains) probably supported by an atypical complement of repetitive sequence in the genome. Comparisons across strains demonstrate that E. huxleyi, which has long been considered a single species, harbours extensive genome variability reflected in different metabolic repertoires. Genome variability within this species complex seems to underpin its capacity both to thrive in habitats ranging from the equator to the subarctic and to form large-scale episodic blooms under a wide variety of environmental conditions.},
  language  = {en}
}
@article{TreatKleinenBroothaertsetal.2019,
  author    = {Treat, Claire C. and Kleinen, Thomas and Broothaerts, Nils and Dalton, April S. and Dommain, Rene and Douglas, Thomas A. and Drexler, Judith Z. and Finkelstein, Sarah A. and Grosse, Guido and Hope, Geoffrey and Hutchings, Jack and Jones, Miriam C. and Kuhry, Peter and Lacourse, Terri and Lahteenoja, Outi and Loisel, Julie and Notebaert, Bastiaan and Payne, Richard J. and Peteet, Dorothy M. and Sannel, A. Britta K. and Stelling, Jonathan M. and Strauss, Jens and Swindles, Graeme T. and Talbot, Julie and Tarnocai, Charles and Verstraeten, Gert and Williams, Christopher J. and Xia, Zhengyu and Yu, Zicheng and Valiranta, Minna and Hattestrand, Martina and Alexanderson, Helena and Brovkin, Victor},
  title     = {Widespread global peatland establishment and persistence over the last 130,000 y},
  series = {Proceedings of the National Academy of Sciences of the United States of America},
  volume    = {116},
  journal   = {Proceedings of the National Academy of Sciences of the United States of America},
  number    = {11},
  publisher = {National Acad. of Sciences},
  address   = {Washington},
  issn      = {0027-8424},
  doi       = {10.1073/pnas.1813305116},
  pages     = {4822 -- 4827},
  year      = {2019},
  abstract  = {Glacial-interglacial variations in CO2 and methane in polar ice cores have been attributed, in part, to changes in global wetland extent, but the wetland distribution before the Last Glacial Maximum (LGM, 21 ka to 18 ka) remains virtually unknown. We present a study of global peatland extent and carbon (C) stocks through the last glacial cycle (130 ka to present) using a newly compiled database of 1,063 detailed stratigraphic records of peat deposits buried by mineral sediments, as well as a global peatland model. Quantitative agreement between modeling and observations shows extensive peat accumulation before the LGM in northern latitudes (> 40 degrees N), particularly during warmer periods including the last interglacial (130 ka to 116 ka, MIS 5e) and the interstadial (57 ka to 29 ka, MIS 3). During cooling periods of glacial advance and permafrost formation, the burial of northern peatlands by glaciers and mineral sediments decreased active peatland extent, thickness, and modeled C stocks by 70 to 90\% from warmer times. Tropical peatland extent and C stocks show little temporal variation throughout the study period. While the increased burial of northern peats was correlated with cooling periods, the burial of tropical peat was predominately driven by changes in sea level and regional hydrology. Peat burial by mineral sediments represents a mechanism for long-term terrestrial C storage in the Earth system. These results show that northern peatlands accumulate significant C stocks during warmer times, indicating their potential for C sequestration during the warming Anthropocene.},
  language  = {en}
}
@article{KhiderEmileGeayMcKayetal.2019,
  author    = {Khider, D. and Emile-Geay, J. and McKay, N. P. and Gil, Y. and Garijo, D. and Ratnakar, V and Alonso-Garcia, M. and Bertrand, S. and Bothe, O. and Brewer, P. and Bunn, A. and Chevalier, M. and Comas-Bru, L. and Csank, A. and Dassie, E. and DeLong, K. and Felis, T. and Francus, P. and Frappier, A. and Gray, W. and Goring, S. and Jonkers, L. and Kahle, M. and Kaufman, D. and Kehrwald, N. M. and Martrat, B. and McGregor, H. and Richey, J. and Schmittner, A. and Scroxton, N. and Sutherland, E. and Thirumalai, Kaustubh and Allen, K. and Arnaud, F. and Axford, Y. and Barrows, T. and Bazin, L. and Birch, S. E. Pilaar and Bradley, E. and Bregy, J. and Capron, E. and Cartapanis, O. and Chiang, H-W and Cobb, K. M. and Debret, M. and Dommain, R{\´e}ne and Du, J. and Dyez, K. and Emerick, S. and Erb, M. P. and Falster, G. and Finsinger, W. and Fortier, D. and Gauthier, Nicolas and George, S. and Grimm, E. and Hertzberg, J. and Hibbert, F. and Hillman, A. and Hobbs, W. and Huber, M. and Hughes, A. L. C. and Jaccard, S. and Ruan, J. and Kienast, M. and Konecky, B. and Le Roux, G. and Lyubchich, V and Novello, V. F. and Olaka, L. and Partin, J. W. and Pearce, C. and Phipps, S. J. and Pignol, C. and Piotrowska, N. and Poli, M-S and Prokopenko, A. and Schwanck, F. and Stepanek, C. and Swann, G. E. A. and Telford, R. and Thomas, E. and Thomas, Z. and Truebe, S. and von Gunten, L. and Waite, A. and Weitzel, N. and Wilhelm, B. and Williams, J. and Winstrup, M. and Zhao, N. and Zhou, Y.},
  title     = {PaCTS 1.0: A Crowdsourced Reporting Standard for Paleoclimate Data},
  series = {Paleoceanography and paleoclimatology},
  volume    = {34},
  journal   = {Paleoceanography and paleoclimatology},
  number    = {10},
  publisher = {American Geophysical Union},
  address   = {Washington},
  issn      = {2572-4517},
  doi       = {10.1029/2019PA003632},
  pages     = {1570 -- 1596},
  year      = {2019},
  abstract  = {The progress of science is tied to the standardization of measurements, instruments, and data. This is especially true in the Big Data age, where analyzing large data volumes critically hinges on the data being standardized. Accordingly, the lack of community-sanctioned data standards in paleoclimatology has largely precluded the benefits of Big Data advances in the field. Building upon recent efforts to standardize the format and terminology of paleoclimate data, this article describes the Paleoclimate Community reporTing Standard (PaCTS), a crowdsourced reporting standard for such data. PaCTS captures which information should be included when reporting paleoclimate data, with the goal of maximizing the reuse value of paleoclimate data sets, particularly for synthesis work and comparison to climate model simulations. Initiated by the LinkedEarth project, the process to elicit a reporting standard involved an international workshop in 2016, various forms of digital community engagement over the next few years, and grassroots working groups. Participants in this process identified important properties across paleoclimate archives, in addition to the reporting of uncertainties and chronologies; they also identified archive-specific properties and distinguished reporting standards for new versus legacy data sets. This work shows that at least 135 respondents overwhelmingly support a drastic increase in the amount of metadata accompanying paleoclimate data sets. Since such goals are at odds with present practices, we discuss a transparent path toward implementing or revising these recommendations in the near future, using both bottom-up and top-down approaches.},
  language  = {en}
}
@article{AbdallaAbramowskiAharonianetal.2016,
  author    = {Abdalla, Hassan E. and Abramowski, Attila and Aharonian, Felix A. and Benkhali, Fai{\c{c}}al Ait and Akhperjanian, A. G. and Ang{\"u}ner, Ekrem Oǧuzhan and Arrieta, M. and Aubert, Pierre and Backes, Michael and Balzer, Arnim and Barnard, Michelle and Becherini, Yvonne and Tjus, Julia Becker and Berge, David and Bernhard, Sabrina and Bernl{\"o}hr, K. and Birsin, E. and Blackwell, R. and Bottcher, Markus and Boisson, Catherine and Bolmont, J. and Bordas, Pol and Bregeon, Johan and Brun, Francois and Brun, Pierre and Bryan, Mark and Bulik, Tomasz and Capasso, M. and Carr, John and Casanova, Sabrina and Chakraborty, N. and Chalme-Calvet, R. and Chaves, Ryan C. G. and Chen, Andrew and Chevalier, J. and Chretien, M. and Colafrancesco, Sergio and Cologna, Gabriele and Condon, B. and Conrad, Jan and Couturier, C. and Cui, Y. and Davids, I. D. and Degrange, B. and Deil, Christoph and deWilt, P. and Djannati-Atai, Arache and Domainko, Wilfried and Donath, Axel and Dubus, Guillaume and Dutson, Kate and Dyks, J. and Dyrda, M. and Edwards, T. and Egberts, Kathrin and Eger, P. and Ernenwein, J. -P. and Eschbach, S. and Farnier, C. and Fegan, Stuart and Fernandes, M. V. and Fiasson, A. and Fontaine, G. and Foerster, A. and Funk, S. and F{\"u}ßling, Matthias and Gabici, Stefano and Gajdus, M. and Gallant, Y. A. and Garrigoux, T. and Giavitto, Gianluca and Giebels, B. and Glicenstein, J. F. and Gottschall, Daniel and Goyal, A. and Grondin, M. -H. and Grudzinska, M. and Hadasch, Daniela and Hahn, J. and Hawkes, J. and Heinzelmann, G. and Henri, Gilles and Hermann, G. and Hervet, Olivier and Hillert, A. and Hinton, James Anthony and Hofmann, Werner and Hoischen, Clemens and Holler, M. and Horns, D. and Ivascenko, Alex and Jacholkowska, A. and Jamrozy, Marek and Janiak, M. and Jankowsky, D. and Jankowsky, Felix and Jingo, M. and Jogler, Tobias and Jouvin, Lea and Jung-Richardt, Ira and Kastendieck, M. A. and Katarzynski, Krzysztof and Katz, Uli and Kerszberg, D. and Khelifi, B. and Kieffer, M. and King, J. and Klepser, S. and Klochkov, Dmitry and Kluzniak, W. and Kolitzus, D. and Komin, Nu. and Kosack, K. and Krakau, S. and Kraus, Michael and Krayzel, F. and Kruger, P. P. and Laffon, H. and Lamanna, G. and Lau, Jeanie and Lees, J. -P. and Lefaucheur, J. and Lefranc, V. and Lemiere, A. and Lemoine-Goumard, M. and Lenain, J. -P. and Leser, Eva and Lohse, Thomas and Lorentz, M. and Lui, R. and Lypova, Iryna and Marandon, Vincent and Marcowith, Alexandre and Mariaud, C. and Marx, R. and Maurin, G. and Maxted, N. and Mayer, Michael and Meintjes, Petrus Johannes and Menzler, U. and Meyer, Manuel and Mitchell, A. M. W. and Moderski, R. and Mohamed, M. and Mora, K. and Moulin, Emmanuel and Murach, T. and de Naurois, Mathieu and Niederwanger, F. and Niemiec, J. and Oakes, L. and Odaka, Hirokazu and Ohm, Stefan and Oettl, S. and Ostrowski, M. and Oya, I. and Padovani, Marco and Panter, M. and Parsons, R. D. and Arribas, M. Paz and Pekeur, N. W. and Pelletier, G. and Petrucci, P. -O. and Peyaud, B. and Pita, S. and Poon, Helen and Prokhorov, Dmitry and Prokoph, Heike and Puehlhofer, Gerd and Punch, Michael and Quirrenbach, Andreas and Raab, S. and Reimer, Anita and Reimer, Olaf and Renaud, M. and de los Reyes, R. and Rieger, Frank and Romoli, Carlo and Rosier-Lees, S. and Rowell, G. and Rudak, B. and Rulten, C. B. and Sahakian, V. and Salek, David and Sanchez, David A. and Santangelo, Andrea and Sasaki, Manami and Schlickeiser, Reinhard and Schussler, F. and Schulz, Andreas and Schwanke, U. and Schwemmer, S. and Seyffert, A. S. and Shafi, N. and Simoni, R. and Sol, H. and Spanier, Felix and Spengler, G. and Spiess, F. and Stawarz, Lukasz and Steenkamp, R. and Stegmann, Christian and Stinzing, F. and Stycz, K. and Sushch, Iurii and Tavernet, J. -P. and Tavernier, T. and Taylor, A. M. and Terrier, R. and Tluczykont, Martin and Trichard, C. and Tuffs, R. and van der Walt, Johan and van Eldik, Christopher and van Soelen, Brian and Vasileiadis, Georges and Veh, J. and Venter, C. and Viana, A. and Vincent, P. and Vink, Jacco and Voisin, F. and Voelk, Heinrich J. and Vuillaume, Thomas and Wadiasingh, Z. and Wagner, Stefan J. and Wagner, P. and Wagner, R. M. and White, R. and Wierzcholska, Alicja and Willmann, P. and Woernlein, A. and Wouters, Denis and Yang, R. and Zabalza, Victor and Zaborov, D. and Zacharias, M. and Zdziarski, A. A. and Zech, Andreas and Zefi, F. and Ziegler, A. and Zywucka, Natalia},
  title     = {Search for Dark Matter Annihilations towards the Inner Galactic Halo from 10 Years of Observations with HESS},
  series = {Physical review letters},
  volume    = {117},
  journal   = {Physical review letters},
  publisher = {American Physical Society},
  address   = {College Park},
  organization    = {HESS Collaboration},
  issn      = {0031-9007},
  doi       = {10.1103/PhysRevLett.117.111301},
  pages     = {6},
  year      = {2016},
  abstract  = {The inner region of the Milky Way halo harbors a large amount of dark matter (DM). Given its proximity, it is one of the most promising targets to look for DM. We report on a search for the annihilations of DM particles using gamma-ray observations towards the inner 300 pc of the Milky Way, with the H.E.S.S. array of ground-based Cherenkov telescopes. The analysis is based on a 2D maximum likelihood method using Galactic Center (GC) data accumulated by H.E.S.S. over the last 10 years (2004-2014), and does not show any significant gamma-ray signal above background. Assuming Einasto and Navarro-Frenk-White DM density profiles at the GC, we derive upper limits on the annihilation cross section <sigma nu >. These constraints are the strongest obtained so far in the TeV DM mass range and improve upon previous limits by a factor 5. For the Einasto profile, the constraints reach <sigma nu > values of 6 x 10(-26) cm(3) s(-1) in the W+W- channel for a DM particle mass of 1.5 TeV, and 2 x 10(-26) cm(3) s(-1) in the tau(+)tau(-) channel for a 1 TeV mass. For the first time, ground-based gamma-ray observations have reached sufficient sensitivity to probe <sigma nu > values expected from the thermal relic density for TeV DM particles.},
  language  = {en}
}
@article{FujiharaZhangJacksonetal.2022,
  author    = {Fujihara, Kenji M. and Zhang, Bonnie Z. and Jackson, Thomas D. and Ogunkola, Moses and Nijagal, Brunda and Milne, Julia V. and Sallman, David A. and Ang, Ching-Seng and Nikolic, Iva and Kearney, Conor J. and Hogg, Simon J. and Cabalag, Carlos S. and Sutton, Vivien R. and Watt, Sally and Fujihara, Asuka T. and Trapani, Joseph A. and Simpson, Kaylene J. and Stojanovski, Diana and Leimk{\"u}hler, Silke and Haupt, Sue and Phillips, Wayne A. and Clemons, Nicholas J.},
  title     = {Eprenetapopt triggers ferroptosis, inhibits NFS1 cysteine desulfurase, and synergizes with serine and glycine dietary restriction},
  series = {Science Advances},
  volume    = {8},
  journal   = {Science Advances},
  number    = {37},
  publisher = {American Assoc. for the Advancement of Science},
  address   = {Washington},
  issn      = {2375-2548},
  doi       = {10.1126/sciadv.abm9427},
  pages     = {13},
  year      = {2022},
  abstract  = {The mechanism of action of eprenetapopt (APR-246, PRIMA-1MET) as an anticancer agent remains unresolved, al-though the clinical development of eprenetapopt focuses on its reported mechanism of action as a mutant-p53 reactivator. Using unbiased approaches, this study demonstrates that eprenetapopt depletes cellular antioxidant glutathione levels by increasing its turnover, triggering a nonapoptotic, iron-dependent form of cell death known as ferroptosis. Deficiency in genes responsible for supplying cancer cells with the substrates for de novo glutathione synthesis (SLC7A11, SHMT2, and MTHFD1L), as well as the enzymes required to synthesize glutathione (GCLC and GCLM), augments the activity of eprenetapopt. Eprenetapopt also inhibits iron-sulfur cluster biogenesis by limit-ing the cysteine desulfurase activity of NFS1, which potentiates ferroptosis and may restrict cellular proliferation. The combination of eprenetapopt with dietary serine and glycine restriction synergizes to inhibit esophageal xenograft tumor growth. These findings reframe the canonical view of eprenetapopt from a mutant-p53 reactivator to a ferroptosis inducer.},
  language  = {en}
}