@article{MatzWangKulshreshthaetal.2022,
  author    = {Matz, Timon W. and Wang, Yang and Kulshreshtha, Ritika and Sampathkumar, Arun and Nikoloski, Zoran},
  title     = {Topological properties accurately predict cell division events and organization of shoot apical meristem in Arabidopsis thaliana},
  series = {Development : Company of Biologists},
  volume    = {149},
  journal   = {Development : Company of Biologists},
  number    = {16},
  publisher = {Company of Biologists},
  address   = {Cambridge},
  issn      = {0950-1991},
  doi       = {10.1242/dev.201024},
  pages     = {11},
  year      = {2022},
  abstract  = {Cell division and the resulting changes to the cell organization affect the shape and functionality of all tissues. Thus, understanding the determinants of the tissue-wide changes imposed by cell division is a key question in developmental biology. Here, we use a network representation of live cell imaging data from shoot apical meristems (SAMs) in Arabidopsis thaliana to predict cell division events and their consequences at the tissue level. We show that a support vector machine classifier based on the SAM network properties is predictive of cell division events, with test accuracy of 76\%, which matches that based on cell size alone. Furthermore, we demonstrate that the combination of topological and biological properties, including cell size, perimeter, distance and shared cell wall between cells, can further boost the prediction accuracy of resulting changes in topology triggered by cell division. Using our classifiers, we demonstrate the importance of microtubule-mediated cell-to-cell growth coordination in influencing tissue-level topology. Together, the results from our network-based analysis demonstrate a feedback mechanism between tissue topology and cell division in A. thaliana SAMs.},
  language  = {en}
}
@article{KleinFeldhahnHarderetal.2004,
  author    = {Klein, Florian and Feldhahn, Niklas and Harder, S. and Wang, Hui and Wartenberg, Maria and Hofmann, W.-K. and Wernet, Peter and Sieber, Reiner and M{\"u}schen, Markus},
  title     = {The BCR-ABL1 kinase bypasses selection for the expressio of a pre-B cell receptor in pre-B acute lymphoblastic leukemia cells},
  year      = {2004},
  language  = {en}
}