@article{GryzikHoangLischkeetal.2020,
  author    = {Gryzik, Stefanie and Hoang, Yen and Lischke, Timo and Mohr, Elodie and Venzke, Melanie and Kadner, Isabelle and P{\"o}tzsch, Josephine and Groth, Detlef and Radbruch, Andreas and Hutloff, Andreas and Baumgrass, Ria},
  title     = {Identification of a super-functional Tfh-like subpopulation in murine lupus by pattern perception},
  series = {eLife},
  volume    = {9},
  journal   = {eLife},
  publisher = {eLife Sciences Publications},
  address   = {Cambridge},
  issn      = {2050-084X},
  doi       = {10.7554/eLife.53226},
  pages     = {21},
  year      = {2020},
  abstract  = {Dysregulated cytokine expression by T cells plays a pivotal role in the pathogenesis of autoimmune diseases. However, the identification of the corresponding pathogenic subpopulations is a challenge, since a distinction between physiological variation and a new quality in the expression of protein markers requires combinatorial evaluation. Here, we were able to identify a super-functional follicular helper T cell (Tfh)-like subpopulation in lupus-prone NZBxW mice with our binning approach "pattern recognition of immune cells (PRI)". PRI uncovered a subpopulation of IL-21(+) IFN-gamma(high) PD-1(low) CD40L(high) CXCR5(-) Bcl-6(-) T cells specifically expanded in diseased mice. In addition, these cells express high levels of TNF-alpha and IL-2, and provide B cell help for IgG production in an IL-21 and CD40L dependent manner. This super-functional T cell subset might be a superior driver of autoimmune processes due to a polyfunctional and high cytokine expression combined with Tfh-like properties.},
  language  = {en}
}