@misc{WelsLenzChristiansetal.2010, author = {Wels, Nicolett and Lenz, Petra and Christians, Heiko and Findeklee, Ulrike and Zimmermann, Matthias and Mangelsdorf, Birgit and Horn-Conrad, Antje and G{\"o}rlich, Petra and Peter, Andreas and Rist, Juri and Voigt, Juliane and Eman, Friderike and Micka, Bettina}, title = {Portal = Glaube und Wissen: Religionswissenschaften im s{\"a}kularen Staat}, number = {04/2010}, organization = {Universit{\"a}t Potsdam, Referat f{\"u}r Presse- und {\"O}ffentlichkeitsarbeit}, issn = {1618-6893}, doi = {10.25932/publishup-44022}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-440225}, pages = {55}, year = {2010}, abstract = {Aus dem Inhalt: - Glauben und Wissen: Religionswissenschaften im s{\"a}kularen Staat - Geheimnisse des Geistes - Mit den D{\"a}nen auf Du und Du}, language = {de} } @article{CuiLoeberAlquezarPlanasetal.2016, author = {Cui, Pin and L{\"o}ber, Ulrike and Alquezar-Planas, David E. and Ishida, Yasuko and Courtiol, Alexandre and Timms, Peter and Johnson, Rebecca N. and Lenz, Dorina and Helgen, Kristofer M. and Roca, Alfred L. and Hartman, Stefanie and Greenwood, Alex D.}, title = {Comprehensive profiling of retroviral integration sites using target enrichment methods from historical koala samples without an assembled reference genome}, series = {PeerJ}, volume = {4}, journal = {PeerJ}, publisher = {PeerJ Inc.}, address = {London}, issn = {2167-8359}, doi = {10.7717/peerj.1847}, pages = {29}, year = {2016}, abstract = {Background. Retroviral integration into the host germline results in permanent viral colonization of vertebrate genomes. The koala retrovirus (KoRV) is currently invading the germline of the koala (Phascolarctos cinereus) and provides a unique opportunity for studying retroviral endogenization. Previous analysis of KoRV integration patterns in modern koalas demonstrate that they share integration sites primarily if they are related, indicating that the process is currently driven by vertical transmission rather than infection. However, due to methodological challenges, KoRV integrations have not been comprehensively characterized. Results. To overcome these challenges, we applied and compared three target enrichment techniques coupled with next generation sequencing (NGS) and a newly customized sequence-clustering based computational pipeline to determine the integration sites for 10 museum Queensland and New South Wales (NSW) koala samples collected between the 1870s and late 1980s. A secondary aim of this study sought to identify common integration sites across modern and historical specimens by comparing our dataset to previously published studies. Several million sequences were processed, and the KoRV integration sites in each koala were characterized. Conclusions. Although the three enrichment methods each exhibited bias in integration site retrieval, a combination of two methods, Primer Extension Capture and hybridization capture is recommended for future studies on historical samples. Moreover, identification of integration sites shows that the proportion of integration sites shared between any two koalas is quite small.}, language = {en} } @article{HahnewaldLeimkuehlerVilasecaetal.2006, author = {Hahnewald, Rita and Leimk{\"u}hler, Silke and Vilaseca, Antonia and Acquaviva-Bourdain, Cecile and Lenz, Ulrike and Reiss, Jochen}, title = {A novel MOCS2 mutation reveals coordinated expression of the small and large subunit of molybdopterin synthase}, series = {Molecular genetics and metabolism}, volume = {89}, journal = {Molecular genetics and metabolism}, number = {3}, publisher = {Elsevier}, address = {San Diego}, issn = {1096-7192}, doi = {10.1016/j.ymgme.2006.04.008}, pages = {210 -- 213}, year = {2006}, abstract = {The small and large subunits of molybdopterin (MPT) synthase (MOCS2A and MOCS2B), are both encoded by the MOCS2 gene in overlapping and shifted open reading frames (ORFs), which is a highly unusual structure for eukaryotes. Theoretical analysis of genomic sequences suggested that the expression of these overlapping ORFs is facilitated by the use of alternate first exons leading to alternative transcripts. Here, we confirm the existence of these overlapping transcripts experimentally. Further, we identified a deletion in a molybdenum cofactor deficient patient, which removes the start codon for the small subunit (MOCS2A). We observed undisturbed production of both transcripts, while Western blot analysis demonstrated that MOCS2B, the large subunit, is unstable in the absence of MOCS2A. This reveals new insights into the expression of this evolutionary ancient anabolic system.}, language = {en} } @book{MoeringPohlRiemeretal.2021, author = {M{\"o}ring, Sebastian and Pohl, Manuela and Riemer, Nathanael and Distelmeyer, Jan and Lenz, Petra and Fritsch, Melanie and Lucke, Ulrike and Moebert, Tobias and Zoerner, Dietmar and Ernst, Sebastian and Wienecke, Maik and Montag, Annegret and Goetz, Ilka}, title = {Didaktik des digitalen Spielens}, series = {DIGAREC Series}, journal = {DIGAREC Series}, number = {09}, editor = {M{\"o}ring, Sebastian and Pohl, Manuela and Riemer, Nathanael}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-511-8}, issn = {1867-6219}, doi = {10.25932/publishup-50957}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-509570}, publisher = {Universit{\"a}t Potsdam}, pages = {318}, year = {2021}, abstract = {Welche Eigenschaften machen das Computerspiel zum geeigneten Medium, das den p{\"a}dagogischen Einsatz im Unterricht bereichern kann? Welche Computerspiele bieten welche M{\"o}glichkeiten zur Auseinandersetzung mit welchen Themen? Wie kann das Computerspiel auch im schulischen Umfeld den f{\"u}r den Lernprozess so wichtigen Lebensweltbezug herstellen? Diese und viele weitere Fragen beantworten die Autor*innen des Bandes „Didaktik des digitalen Spielens". Daf{\"u}r begeben sie sich in einen Dialog der Wissenschaftsdisziplinen, leiten M{\"o}glichkeiten zum Einsatz von Computerspielen ab und werten Erfahrungen mit dem Einsatz von Computerspielen - auch in der Lehrendenbildung - aus. Mit ihren verschiedenen Zug{\"a}ngen zu Fragestellungen rund um eine „Didaktik des digitalen Spielens" liefern sie einen Beitrag zu einem Diskurs, der besonders in Zeiten von Distanzunterricht notwendig und folgerichtig gef{\"u}hrt werden muss. Die im Rahmen der gleichnamigen interdisziplin{\"a}ren Ringvorlesung im Wintersemester 2018/19 an der Universit{\"a}t Potsdam gehaltenen Vortr{\"a}ge sind durch die Diskussionen mit Studierenden gepr{\"a}gt und ausgewertet worden, so dass sie in der nun ver{\"o}ffentlichten Form auf mehreren Ebenen einen mehrperspektivischen Blick auf den Gegenstand „Computerspiel im Unterricht" legen.}, language = {de} } @article{AndreevNazarovaLenzetal.2022, author = {Andreev, Andrei and Nazarova, Larisa B. and Lenz, Marlene M. and B{\"o}hmer, Thomas and Syrykh, Ludmila and Wagner, Bernd and Melles, Martin and Pestryakova, Luidmila A. and Herzschuh, Ulrike}, title = {Late Quaternary paleoenvironmental reconstructions from sediments of Lake Emanda (Verkhoyansk Mountains, East Siberia)}, series = {Journal of quaternary science : JQS}, volume = {37}, journal = {Journal of quaternary science : JQS}, number = {5}, publisher = {Wiley}, address = {New York, NY [u.a.]}, issn = {0267-8179}, doi = {10.1002/jqs.3419}, pages = {884 -- 899}, year = {2022}, abstract = {Continuous pollen and chironomid records from Lake Emanda (65 degrees 17'N, 135 degrees 45'E) provide new insights into the Late Quaternary environmental history of the Yana Highlands (Yakutia). Larch forest with shrubs (alders, pines, birches) dominated during the deposition of the lowermost sediments suggesting its Early Weichselian [Marine Isotope Stage (MIS) 5] age. Pollen- and chironomid-based climate reconstructions suggest July temperatures (T-July) slightly lower than modern. Gradually increasing amounts of herb pollen and cold stenotherm chironomid head capsules reflect cooler and drier environments, probably during the termination of MIS 5. T-July dropped to 8 degrees C. Mostly treeless vegetation is reconstructed during MIS 3. Tundra and steppe communities dominated during MIS 2. Shrubs became common after similar to 14.5 ka BP but herb-dominated habitats remained until the onset of the Holocene. Larch forests with shrub alder and dwarf birch dominated after the Holocene onset, ca. 11.7 ka BP. Decreasing amounts of shrub pollen during the Lateglacial are assigned to the Older Dryas and Younger Dryas with T-July similar to 7.5 degrees C. T-July increased up to 13 degrees C. Shrub stone pine was present after similar to 7.5 ka BP. The vegetation has been similar to modern since ca. 5.8 ka BP. Chironomid diversity and concentration in the sediments increased towards the present day, indicating the development of richer hydrobiological communities in response to the Holocene thermal maximum.}, language = {en} }