@article{FrankFrank2022, author = {Frank, Ulrike and Frank, Katrin}, title = {COVID-19}, series = {Der Nervenarzt : Organ der Deutschen Gesellschaft f{\"u}r Psychiatrie, Psychotherapie und Nervenheilkunde ; Mitteilungsblatt der Deutschen Gesellschaft f{\"u}r Neurologie}, volume = {93}, journal = {Der Nervenarzt : Organ der Deutschen Gesellschaft f{\"u}r Psychiatrie, Psychotherapie und Nervenheilkunde ; Mitteilungsblatt der Deutschen Gesellschaft f{\"u}r Neurologie}, number = {2}, publisher = {Springer}, address = {New York}, issn = {0028-2804}, doi = {10.1007/s00115-021-01162-5}, pages = {167 -- 174}, year = {2022}, abstract = {Eine COVID-19-Erkrankung kann zu schweren Krankheitsverl{\"a}ufen mit multiplen Organbeteiligungen und respiratorischen und neurologischen Funktionseinschr{\"a}nkungen f{\"u}hren. Schluckst{\"o}rungen (Dysphagien) k{\"o}nnen in dieser Patientengruppe durch prim{\"a}re Sch{\"a}digungen des zentralen und peripheren neuronalen Netzwerkes der Schluckfunktion entstehen, aber auch bedingt durch die h{\"a}ufig l{\"a}ngere intensivmedizinische Behandlung und Beatmung. Erste klinische Befunde zeigen persistierende Dysphagien im Rahmen des Post-COVID-Syndroms („Long-COVID"), sodass die Patienten auch l{\"a}ngerfristige Maßnahmen zur Rehabilitation einer sicheren und suffizienten oralen Nahrungsaufnahme ben{\"o}tigen. Daher sollte in die Behandlung von COVID-19-Patienten ein strukturiertes erkrankungsspezifisches Monitoring in Bezug auf Dysphagiesymptome integriert werden, und atemtherapeutische Maßnahmen zur Regulation von Husteneffektivit{\"a}t und Atem-Schluck-Koordination sollten auch bei diesen Patienten essenzieller Bestandteil des Dysphagiemanagements sein. Herausforderungen ergeben sich dabei einerseits durch die erforderlichen Anpassungen etablierter Behandlungsstandards an den Infektionsschutz. Zudem m{\"u}ssen Auswahl und Durchf{\"u}hrungsintensit{\"a}t therapeutischer Maßnahmen an die Kapazit{\"a}ten und die spezifische Pathophysiologie der COVID-19- und Long-COVID-Patienten angepasst werden, um weitere funktionelle Verschlechterungen zu vermindern.}, language = {de} } @article{VogelClausAhringetal.2022, author = {Vogel, Annemarie and Claus, Inga and Ahring, Sigrid and Gruber, Doreen and Haghikia, Aiden and Frank, Ulrike and Dziewas, Rainer and Ebersbach, Georg and Gandor, Florin and Warnecke, Tobias}, title = {Endoscopic characteristics of dysphagia in multiple system atrophy}, series = {Movement disorders : official journal of the Movement Disorder Society}, volume = {37}, journal = {Movement disorders : official journal of the Movement Disorder Society}, number = {3}, publisher = {Wiley-Blackwell}, address = {Hoboken}, issn = {0885-3185}, doi = {10.1002/mds.28854}, pages = {535 -- 544}, year = {2022}, abstract = {Background Dysphagia is a major clinical concern in multiple system atrophy (MSA). A detailed evaluation of its major endoscopic features compared with Parkinson's disease (PD) is lacking. Objective This study systematically assessed dysphagia in MSA compared with PD and correlated subjective dysphagia to objective endoscopic findings. Methods Fifty-seven patients with MSA (median, 64 [interquartile range (IQR): 59-71] years; 35 women) underwent flexible endoscopic evaluation of swallowing using a specific MSA-flexible endoscopic evaluation of swallowing task protocol. Findings were compared with an age-matched cohort of 57 patients with PD (median, 67 [interquartile range: 60-73] years; 28 women). In a subcohort, subjective dysphagia was assessed using the Swallowing Disturbance Questionnaire and correlated to endoscopy findings. Results Patients with MSA predominantly showed symptoms suggestive of oral-phase disturbance (premature spillage, 75.4\%, piecemeal deglutition, 75.4\%). Pharyngeal-phase symptoms occurred less often (pharyngeal residues, 50.9\%; penetration/aspiration, 28.1\%). In contrast, pharyngeal symptoms were the most common finding in PD (pharyngeal residues, 47.4\%). Oral symptoms occurred less frequently in PD (premature spillage, 15.8\%, P < 0.001; piecemeal deglutition, 1.8\%, P < 0.01). Patients with MSA had a greater risk for oral-phase disturbances with increased disease severity (P < 0.05; odds ratio, 3.15). Patients with MSA showed a significantly higher intraindividual interswallow variability compared with PD. When correlating Swallowing Disturbance Questionnaire scores with endoscopy results, its cutoff, validated for PD, was not sensitive enough to identify patients with MSA with dysphagia. We developed a subscore for identifying dysphagia in MSA and calculated a new cutoff (sensitivity 85\%, specificity 100\%). Conclusions In contrast with patients with PD, patients with dysphagic MSA more frequently present with oral-phase symptoms and a significantly higher intraindividual interswallow variability. A novel Swallowing Disturbance Questionnaire MSA subscore may be a valuable tool to identify patients with MSA with early oropharyngeal dysphagia.}, language = {en} } @article{MuellerBeerFrank2022, author = {M{\"u}ller, Nina and Beer, Carola de and Frank, Ulrike}, title = {Ist die therapeutische Mundpflege bei Dysphagiepatient*innen verschwendete Zeit?}, series = {Sprache, Stimme, Geh{\"o}r : Zeitschrift f{\"u}r Kommunikationsst{\"o}rungen}, volume = {46}, journal = {Sprache, Stimme, Geh{\"o}r : Zeitschrift f{\"u}r Kommunikationsst{\"o}rungen}, number = {03}, publisher = {Thieme}, address = {Stuttgart}, issn = {0342-0477}, doi = {10.1055/a-1714-1587}, pages = {150 -- 155}, year = {2022}, abstract = {Aspirationspneumonien sind eine h{\"a}ufige Todesursache bei Dysphagiepatient*innen. In diesem Beitrag wird durch die Evaluation relevanter Studien die Frage untersucht, ob die therapeutische Mundpflege bei Dysphagiepatient*innen zur Verringerung des Pneumonierisikos beitragen kann. Zudem wird auf dieser Grundlage eine Handlungsempfehlung f{\"u}r die Umsetzung der Mundpflege entwickelt. Die ausgew{\"a}hlten Studien zeigen, dass die Mundpflege einen positiven Effekt auf das Pneumonie-Risiko von Dysphagiepatient*innen hat. Sie sollte auf den Grunds{\"a}tzen Einfachheit, Sicherheit, Arbeitskr{\"a}fteentlastung, Wirksamkeit, Universalit{\"a}t, Wirtschaftlichkeit und vollst{\"a}ndige Mundpflege aller Teile der Mundh{\"o}hle beruhen und nimmt weniger als f{\"u}nf Minuten t{\"a}glich ein. Sie bereitet durch die taktile Stimulation auf die anschließende Dysphagie-Therapie vor und ist somit sinnvoll investierte Therapiezeit.}, language = {de} } @misc{FrankFrankMohretal.2022, author = {Frank, Ulrike and Frank, Katrin and Mohr, Bettina and Kurtenbach, Stephanie and Khader-Lindholz, Aischa and Sallat, Stephan and Wagner, Lilli and D{\"u}ring, Sarah and Lubitz, Anika and Schnelle, Kirsten and Klitsch, Julia and Netzebandt, Jonka and Fritsche, Tom and Uhlemann, Charlotte and Wartenburger, Isabell and Hilton, Matt and Neitzel, Isabel and Schmidt, Johanna and Eikerling, Maren and Cholin, Joana and Menze, Clara and Stadie, Nicole and Schmitz-Antonischki, Dorit and Heide, Judith and Plath, Almut and Corsten, Sabine and Hoffmann, Marie and Leinweber, Juliane and Spelter, Bianca and Karstens, Sven}, title = {Spektrum Patholinguistik Band 15. Schwerpunktthema: Interdisziplin{\"a}r behandeln - Multiprofessionelle Zusammenarbeit in der Sprachtherapie}, series = {Spektrum Patholinguistik}, journal = {Spektrum Patholinguistik}, number = {15}, editor = {Tan, Sarah and D{\"u}ring, Sarah and Wilde, Alina and Wunderlich, Hanna and Fritzsche, Tom}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-542-2}, issn = {1866-9433}, doi = {10.25932/publishup-55820}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-558206}, pages = {vii, 180}, year = {2022}, abstract = {Das 15. Herbsttreffen Patholinguistik mit dem Schwerpunktthema »Interdisziplin{\"a}r (be-)handeln - Multiprofessionelle Zusammenarbeit in der Sprachtherapie« fand am 20.11.2021 als Online-Veranstaltung statt. Das Herbsttreffen wird seit 2007 j{\"a}hrlich vom Verband f{\"u}r Patholinguistik e.V. (vpl), seit 2021 vom Deutschen Bundesverband f{\"u}r akademische Sprachtherapie und Logop{\"a}die (dbs) in Kooperation mit der Universit{\"a}t Potsdam durchgef{\"u}hrt. Der vorliegende Tagungsband beinhaltet die Vortr{\"a}ge zum Schwerpunktthema und Informationen aus der Podiumsdiskussion sowie die Posterpr{\"a}sentationen zu weiteren Themen aus der sprachtherapeutischen Forschung und Praxis.}, language = {de} } @article{FrankFrank2022, author = {Frank, Ulrike and Frank, Katrin}, title = {Teamwork is it!}, series = {Spektrum Patholinguistik 15}, journal = {Spektrum Patholinguistik 15}, number = {15}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-542-2}, issn = {1866-9433}, doi = {10.25932/publishup-57213}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-572134}, pages = {1 -- 19}, year = {2022}, language = {de} } @article{DunkerBoydDurkaetal.2022, author = {Dunker, Susanne and Boyd, Matthew and Durka, Walter and Erler, Silvio and Harpole, W. Stanley and Henning, Silvia and Herzschuh, Ulrike and Hornick, Thomas and Knight, Tiffany and Lips, Stefan and M{\"a}der, Patrick and Švara, Elena Motivans and Mozarowski, Steven and Rakosy, Demetra and R{\"o}mermann, Christine and Schmitt-Jansen, Mechthild and Stoof-Leichsenring, Kathleen and Stratmann, Frank and Treudler, Regina and Virtanen, Risto and Wendt-Potthoff, Katrin and Wilhelm, Christian}, title = {The potential of multispectral imaging flow cytometry for environmental monitoring}, series = {Cytometry part A}, volume = {101}, journal = {Cytometry part A}, number = {9}, publisher = {Wiley}, address = {Hoboken}, issn = {1552-4922}, doi = {10.1002/cyto.a.24658}, pages = {782 -- 799}, year = {2022}, abstract = {Environmental monitoring involves the quantification of microscopic cells and particles such as algae, plant cells, pollen, or fungal spores. Traditional methods using conventional microscopy require expert knowledge, are time-intensive and not well-suited for automated high throughput. Multispectral imaging flow cytometry (MIFC) allows measurement of up to 5000 particles per second from a fluid suspension and can simultaneously capture up to 12 images of every single particle for brightfield and different spectral ranges, with up to 60x magnification. The high throughput of MIFC has high potential for increasing the amount and accuracy of environmental monitoring, such as for plant-pollinator interactions, fossil samples, air, water or food quality that currently rely on manual microscopic methods. Automated recognition of particles and cells is also possible, when MIFC is combined with deep-learning computational techniques. Furthermore, various fluorescence dyes can be used to stain specific parts of the cell to highlight physiological and chemical features including: vitality of pollen or algae, allergen content of individual pollen, surface chemical composition (carbohydrate coating) of cells, DNA- or enzyme-activity staining. Here, we outline the great potential for MIFC in environmental research for a variety of research fields and focal organisms. In addition, we provide best practice recommendations.}, language = {en} }