@article{vanderValkKreinerMollerKooijmanetal.2015,
  author    = {van der Valk, Ralf J. P. and Kreiner-Moller, Eskil and Kooijman, Marjolein N. and Guxens, Monica and Stergiakouli, Evangelia and Saaf, Annika and Bradfield, Jonathan P. and Geller, Frank and Hayes, M. Geoffrey and Cousminer, Diana L. and Koerner, Antje and Thiering, Elisabeth and Curtin, John A. and Myhre, Ronny and Huikari, Ville and Joro, Raimo and Kerkhof, Marjan and Warrington, Nicole M. and Pitkanen, Niina and Ntalla, Ioanna and Horikoshi, Momoko and Veijola, Riitta and Freathy, Rachel M. and Teo, Yik-Ying and Barton, Sheila J. and Evans, David M. and Kemp, John P. and St Pourcain, Beate and Ring, Susan M. and Smith, George Davey and Bergstrom, Anna and Kull, Inger and Hakonarson, Hakon and Mentch, Frank D. and Bisgaard, Hans and Chawes, Bo Lund Krogsgaard and Stokholm, Jakob and Waage, Johannes and Eriksen, Patrick and Sevelsted, Astrid and Melbye, Mads and van Duijn, Cornelia M. and Medina-Gomez, Carolina and Hofman, Albert and de Jongste, Johan C. and Taal, H. Rob and Uitterlinden, Andre G. and Armstrong, Loren L. and Eriksson, Johan and Palotie, Aarno and Bustamante, Mariona and Estivill, Xavier and Gonzalez, Juan R. and Llop, Sabrina and Kiess, Wieland and Mahajan, Anubha and Flexeder, Claudia and Tiesler, Carla M. T. and Murray, Clare S. and Simpson, Angela and Magnus, Per and Sengpiel, Verena and Hartikainen, Anna-Liisa and Keinanen-Kiukaanniemi, Sirkka and Lewin, Alexandra and Alves, Alexessander Da Silva Couto and Blakemore, Alexandra I. F. and Buxton, Jessica L. and Kaakinen, Marika and Rodriguez, Alina and Sebert, Sylvain and Vaarasmaki, Marja and Lakka, Timo and Lindi, Virpi and Gehring, Ulrike and Postma, Dirkje S. and Ang, Wei and Newnham, John P. and Lyytikainen, Leo-Pekka and Pahkala, Katja and Raitakari, Olli T. and Panoutsopoulou, Kalliope and Zeggini, Eleftheria and Boomsma, Dorret I. and Groen-Blokhuis, Maria and Ilonen, Jorma and Franke, Lude and Hirschhorn, Joel N. and Pers, Tune H. and Liang, Liming and Huang, Jinyan and Hocher, Berthold and Knip, Mikael and Saw, Seang-Mei and Holloway, John W. and Melen, Erik and Grant, Struan F. A. and Feenstra, Bjarke and Lowe, William L. and Widen, Elisabeth and Sergeyev, Elena and Grallert, Harald and Custovic, Adnan and Jacobsson, Bo and Jarvelin, Marjo-Riitta and Atalay, Mustafa and Koppelman, Gerard H. and Pennell, Craig E. and Niinikoski, Harri and Dedoussis, George V. and Mccarthy, Mark I. and Frayling, Timothy M. and Sunyer, Jordi and Timpson, Nicholas J. and Rivadeneira, Fernando and Bonnelykke, Klaus and Jaddoe, Vincent W. V.},
  title     = {A novel common variant in DCST2 is associated with length in early life and height in adulthood},
  series = {Human molecular genetics},
  volume    = {24},
  journal   = {Human molecular genetics},
  number    = {4},
  publisher = {Oxford Univ. Press},
  address   = {Oxford},
  organization    = {Early Genetics Lifecourse, Genetic Invest ANthropometric, Early Growth Genetics EGG},
  issn      = {0964-6906},
  doi       = {10.1093/hmg/ddu510},
  pages     = {1155 -- 1168},
  year      = {2015},
  abstract  = {Common genetic variants have been identified for adult height, but not much is known about the genetics of skeletal growth in early life. To identify common genetic variants that influence fetal skeletal growth, we meta-analyzed 22 genome-wide association studies (Stage 1; N = 28 459). We identified seven independent top single nucleotide polymorphisms (SNPs) (P < 1 x 10(-6)) for birth length, of which three were novel and four were in or near loci known to be associated with adult height (LCORL, PTCH1, GPR126 and HMGA2). The three novel SNPs were followed-up in nine replication studies (Stage 2; N = 11 995), with rs905938 in DC-STAMP domain containing 2 (DCST2) genome-wide significantly associated with birth length in a joint analysis (Stages 1 + 2; beta = 0.046, SE = 0.008, P = 2.46 x 10(-8), explained variance = 0.05\%). Rs905938 was also associated with infant length (N = 28 228; P = 5.54 x 10(-4)) and adult height (N = 127 513; P = 1.45 x 10(-5)). DCST2 is a DC-STAMP-like protein family member and DC-STAMP is an osteoclast cell-fusion regulator. Polygenic scores based on 180 SNPs previously associated with human adult stature explained 0.13\% of variance in birth length. The same SNPs explained 2.95\% of the variance of infant length. Of the 180 known adult height loci, 11 were genome-wide significantly associated with infant length (SF3B4, LCORL, SPAG17, C6orf173, PTCH1, GDF5, ZNFX1, HHIP, ACAN, HLA locus and HMGA2). This study highlights that common variation in DCST2 influences variation in early growth and adult height.},
  language  = {en}
}
@article{NeuschaeferRubeOppermannMoelleretal.1999,
  author    = {Neusch{\"a}fer-Rube, Frank and Oppermann, Martin and M{\"o}ller, Ulrike and B{\"o}er, Ulrike and P{\"u}schel, Gerhard Paul},
  title     = {Agonist-induced phosphorylation by G protein-coupled receptor kinases of the EP4 receptor carboxyl-terminal domain in an EP3/EP4 prostaglandin E(2) receptor hybrid},
  issn      = {1521-0111},
  year      = {1999},
  abstract  = {Prostaglandin E(2) receptors (EP-Rs) belong to the family of heterotrimeric G protein-coupled ectoreceptors with seven transmembrane domains. They can be subdivided into four subtypes according to their ligand-binding and G protein-coupling specificity: EP1 couple to G(q), EP2 and EP4 to G(s), and EP3 to G(i). The EP4-R, in contrast to the EP3beta-R, shows rapid agonist-induced desensitization. The agonist-induced desensitization depends on the presence of the EP4-R carboxyl-terminal domain, which also confers desensitization in a G(i)-coupled rEP3hEP4 carboxyl-terminal domain receptor hybrid (rEP3hEP4-Ct-R). To elucidate the possible mechanism of this desensitization, in vivo phosphorylation stimulated by activators of second messenger kinases, by prostaglandin E(2), or by the EP3-R agonist M\&B28767 was investigated in COS-7 cells expressing FLAG-epitope-tagged rat EP3beta-R (rEP3beta-R), hEP4-R, or rEP3hEP4- Ct-R. Stimulation of protein kinase C with phorbol-12-myristate-13-acetate led to a slight phosphorylation of the FLAG- rEP3beta-R but to a strong phosphorylation of the FLAG-hEP4-R and the FLAG-rEP3hEP4-Ct-R, which was suppressed by the protein kinase A and protein kinase C inhibitor staurosporine. Prostaglandin E(2) stimulated phosphorylation of the FLAG- hEP4-R in its carboxyl-terminal receptor domain. The EP3-R agonist M\&B28767 induced a time- and dose-dependent phosphorylation of the FLAG-rEP3hEP4-Ct-R but not of the FLAG-rEP3beta-R. Agonist-induced phosphorylation of the FLAG- hEP4-R and the FLAG-rEP3hEP4-Ct-R were not inhibited by staurosporine, which implies a role of G protein-coupled receptor kinases (GRKs) in agonist-induced receptor phosphorylation. Overexpression of GRKs in FLAG-rEP3hEP4-Ct-R- expressing COS-7 cells augmented the M\&B28767-induced receptor phosphorylation and receptor sequestration. These findings indicate that phosphorylation of the carboxyl-terminal hEP4-R domain possibly by GRKs but not by second messenger kinases may be involved in rapid agonist-induced desensitization of the hEP4-R and the rEP3hEP4-Ct-R.},
  language  = {en}
}
@article{ThonickeFrank2015,
  author    = {Thonicke, Mady and Frank, Ulrike},
  title     = {Biofeedback in der Dysphagietherapie},
  series = {Spektrum Patholinguistik (Band 8) - Schwerpunktthema: Besonders behandeln? : Sprachtherapie im Rahmen prim{\"a}rer St{\"o}rungsbilder},
  journal   = {Spektrum Patholinguistik (Band 8) - Schwerpunktthema: Besonders behandeln? : Sprachtherapie im Rahmen prim{\"a}rer St{\"o}rungsbilder},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-79891},
  pages     = {243 -- 247},
  year      = {2015},
  language  = {de}
}
@article{FrankFrank2022,
  author    = {Frank, Ulrike and Frank, Katrin},
  title     = {COVID-19},
  series = {Der Nervenarzt : Organ der Deutschen Gesellschaft f{\"u}r Psychiatrie, Psychotherapie und Nervenheilkunde ; Mitteilungsblatt der Deutschen Gesellschaft f{\"u}r Neurologie},
  volume    = {93},
  journal   = {Der Nervenarzt : Organ der Deutschen Gesellschaft f{\"u}r Psychiatrie, Psychotherapie und Nervenheilkunde ; Mitteilungsblatt der Deutschen Gesellschaft f{\"u}r Neurologie},
  number    = {2},
  publisher = {Springer},
  address   = {New York},
  issn      = {0028-2804},
  doi       = {10.1007/s00115-021-01162-5},
  pages     = {167 -- 174},
  year      = {2022},
  abstract  = {Eine COVID-19-Erkrankung kann zu schweren Krankheitsverl{\"a}ufen mit multiplen Organbeteiligungen und respiratorischen und neurologischen Funktionseinschr{\"a}nkungen f{\"u}hren. Schluckst{\"o}rungen (Dysphagien) k{\"o}nnen in dieser Patientengruppe durch prim{\"a}re Sch{\"a}digungen des zentralen und peripheren neuronalen Netzwerkes der Schluckfunktion entstehen, aber auch bedingt durch die h{\"a}ufig l{\"a}ngere intensivmedizinische Behandlung und Beatmung. Erste klinische Befunde zeigen persistierende Dysphagien im Rahmen des Post-COVID-Syndroms („Long-COVID"), sodass die Patienten auch l{\"a}ngerfristige Maßnahmen zur Rehabilitation einer sicheren und suffizienten oralen Nahrungsaufnahme ben{\"o}tigen. Daher sollte in die Behandlung von COVID-19-Patienten ein strukturiertes erkrankungsspezifisches Monitoring in Bezug auf Dysphagiesymptome integriert werden, und atemtherapeutische Maßnahmen zur Regulation von Husteneffektivit{\"a}t und Atem-Schluck-Koordination sollten auch bei diesen Patienten essenzieller Bestandteil des Dysphagiemanagements sein. Herausforderungen ergeben sich dabei einerseits durch die erforderlichen Anpassungen etablierter Behandlungsstandards an den Infektionsschutz. Zudem m{\"u}ssen Auswahl und Durchf{\"u}hrungsintensit{\"a}t therapeutischer Maßnahmen an die Kapazit{\"a}ten und die spezifische Pathophysiologie der COVID-19- und Long-COVID-Patienten angepasst werden, um weitere funktionelle Verschlechterungen zu vermindern.},
  language  = {de}
}
@article{DuesterhoeftFrank2011,
  author    = {D{\"u}sterh{\"o}ft, Stefanie and Frank, Ulrike},
  title     = {Das PNF-Konzept},
  series = {Spektrum Patholinguistik},
  journal   = {Spektrum Patholinguistik},
  number    = {4},
  issn      = {1869-3822},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-54306},
  pages     = {171 -- 183},
  year      = {2011},
  language  = {de}
}
@article{DuesterhoeftFrank2011,
  author    = {D{\"u}sterh{\"o}ft, Stefanie and Frank, Ulrike},
  title     = {Das PNF-Konzept Anwendung in der orofacialen Therapie},
  year      = {2011},
  language  = {de}
}
@article{SticherCzepluchMaetzeneretal.2011,
  author    = {Sticher, Heike and Czepluch, Christine and M{\"a}tzener, Flurina and Wilmes, Stefanie and Hadert, Sandra and Frank, Ulrike and M{\"a}der, Mark},
  title     = {Dekan{\"u}lierungsmanagement bei Patienten mit respiratorischen Beeintr{\"a}chtigungen und Dysphagie},
  series = {Spektrum Patholinguistik},
  journal   = {Spektrum Patholinguistik},
  number    = {4},
  issn      = {1869-3822},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-54277},
  pages     = {141 -- 142},
  year      = {2011},
  language  = {de}
}
@article{SticherCzepluchMaetzeneretal.2011,
  author    = {Sticher, Heike and Czepluch, Christine and M{\"a}tzener, Flurina and Wilmes, Stefanie and Hadert, Sandra and Frank, Ulrike and M{\"a}der, Mark},
  title     = {Dekan{\"u}lierungsmanagment bei Patienten mit respiratorischen Beeintr{\"a}chtigungen und Dysphagie},
  year      = {2011},
  language  = {de}
}
@article{PosseFrank2011,
  author    = {Posse, Dorothea and Frank, Ulrike},
  title     = {Der Einfluss des Lee Silverman Voice Treatment (LSVT) auf die Hypernasalit{\"a}t bei Dysarthrie},
  series = {Spektrum Patholinguistik},
  journal   = {Spektrum Patholinguistik},
  number    = {4},
  issn      = {1869-3822},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-54313},
  pages     = {185 -- 187},
  year      = {2011},
  language  = {de}
}
@article{PosseFrank2011,
  author    = {Posse, Dorothea and Frank, Ulrike},
  title     = {Der Einfluss des Lee Silverman Voice Treatment (LSVT) auf die Hypernasalit{\"a}t bei Dysarthrie},
  year      = {2011},
  language  = {de}
}
@article{PeiffersFrank2015,
  author    = {Peiffers, Sabine and Frank, Ulrike},
  title     = {Der Einfluss von K{\"o}rperparametern auf das Schluckvolumen bei gesunden Erwachsenen},
  series = {Spektrum Patholinguistik (Band 8) - Schwerpunktthema: Besonders behandeln? : Sprachtherapie im Rahmen prim{\"a}rer St{\"o}rungsbilder},
  journal   = {Spektrum Patholinguistik (Band 8) - Schwerpunktthema: Besonders behandeln? : Sprachtherapie im Rahmen prim{\"a}rer St{\"o}rungsbilder},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-79882},
  pages     = {239 -- 242},
  year      = {2015},
  language  = {de}
}
@article{PuritzSeidlFrank2011,
  author    = {Puritz, Caroline and Seidl, Rainer Ottis and Frank, Ulrike},
  title     = {Die Auswirkungen des Lee Silverman Voice Treatments (LSVT) auf die kortikalen Repr{\"a}sentation der Schluckmuskulatur bei Patienten mit Morbus Parkinson},
  year      = {2011},
  language  = {de}
}
@article{PuritzSeidlFrank2011,
  author    = {Puritz, Caroline and Seidl, Rainer Ottis and Frank, Ulrike},
  title     = {Die Auswirkungen des Lee Silverman Voice Treatments (LSVT) auf die kortikalen Repr{\"a}sentationen der Schluckmuskulatur bei Patienten mit Morbus Parkinson},
  series = {Spektrum Patholinguistik},
  journal   = {Spektrum Patholinguistik},
  number    = {4},
  issn      = {1869-3822},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-54322},
  pages     = {189 -- 191},
  year      = {2011},
  language  = {de}
}
@phdthesis{Frank2008,
  author    = {Frank, Ulrike},
  title     = {Die Behandlung tracheotomierter Patienten mit schwerer Dysphagie : eine explorative Studie zur Evaluation eines interdisziplin{\"a}ren Interventionsansatzes},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-940793-55-3},
  doi       = {10.25932/publishup-2451},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-20164},
  school      = {Universit{\"a}t Potsdam},
  pages     = {232},
  year      = {2008},
  abstract  = {In der neurologischen Rehabilitation werden in zunehmendem Maße tracheotomierte Patienten mit schweren Dysphagien behandelt. Daher sollte den hierzu bisher entwickelten Interventionsverfahren eine evidenzbasierte Grundlage gegeben werden. In der vorliegenden Arbeit wird ein multidisziplin{\"a}rer Behandlungsansatz zur Trachealkan{\"u}lenentw{\"o}hung und Dekan{\"u}lierung vorgestellt, der auf der Grundlage der relevanten Forschungsliteratur und klinischen Beobachtungen entwickelt wurde. Des Weiteren wird erstmals eine systematische Evaluation eines multidisziplin{\"a}ren Trachealkan{\"u}lenmangements vorgenommen und es werden explorative Daten zum Rehabilitationsverlauf dargestellt. In einem retrospektiven Vergleich wurden hierzu die Dekan{\"u}lierungs- und Komplikationsraten sowie die Dauer der Trachealkan{\"u}lenentw{\"o}hnung zweier Patientengruppen gegen{\"u}bergestellt, die vor bzw. nach Einf{\"u}hrung des beschriebenen multidisziplin{\"a}ren Trachealkan{\"u}lenmanagements im REHAB Basel, Schweiz, behandelt wurden. Der rehabilitative Verlauf der multidisziplin{\"a}r behandelten Gruppe wurde mittels der Messinstrumente FIM (Functional Independence Measure) und EFA (Early Functional Abilities) untersucht. Der Vergleich der Dekan{\"u}lierungs- und Komplikationsraten ergab eine vergleichbare Effektivit{\"a}t der beiden Behandlungsans{\"a}tze. Dar{\"u}ber hinaus zeigte sich eine signifikante Verk{\"u}rzung der Kan{\"u}lenentw{\"o}hnungsphase bei Anwendung des multidisziplin{\"a}ren Vorgehens, so dass dieses als effizenter zu beurteilen ist. Die Verlaufsanalyse der multidisziplin{\"a}r behandelten Patienten ergab erst nach der Dekan{\"u}lierung einen signifikanten Zuwachs der funktionellen Selbst{\"a}ndigkeit in Alltagsaktivit{\"a}ten. Bei der Mehrzahl der Patienten konnte ein vollst{\"a}ndiger oraler Kostaufbau nach der Dekan{\"u}lierung erreicht werden.},
  language  = {de}
}
@article{HummelFrank2010,
  author    = {Hummel, Katja and Frank, Ulrike},
  title     = {Die Schluckfrequenz bei Gesunden in Seiten- vs. R{\"u}ckenlage},
  series = {Spektrum Patholinguistik},
  volume    = {3},
  journal   = {Spektrum Patholinguistik},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  issn      = {1866-9085},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-47077},
  pages     = {187 -- 190},
  year      = {2010},
  language  = {de}
}
@article{DrygalaWernerZoller2013,
  author    = {Drygala, Frank and Werner, Ulrike and Zoller, Hinrich},
  title     = {Diet composition of the invasive raccoon dog (Nyctereutes procyonoides) and the native red fox (Vulpes vulpes) in north-east Germany},
  series = {Hystrix : the Italian journal of mammalogy},
  volume    = {24},
  journal   = {Hystrix : the Italian journal of mammalogy},
  number    = {2},
  publisher = {Associazione Teriologica Romana},
  address   = {Roma},
  issn      = {0394-1914},
  doi       = {10.4404/hystrix.-24.2-8867},
  pages     = {190 -- 194},
  year      = {2013},
  abstract  = {Invasive alien species pose a great threat to the integrity of natural communities by competition with and predation on native species. In Germany the invasive raccoon dog (Nyctereutes procyonoides) and the native red fox (Vulpes vulpes) occupy a similar ecological niche. Therefore, the aim of our study was to discover the extent of exploitative diet competition between these two generalist carnivores. Carcasses of red foxes (n=256) and raccoon dogs (n=253) were collected throughout Mecklenburg Western-Pomerania (north-east Germany) and stomachs contains were analysed. Frequency of occurrence and biomass share indicate that both canids are omnivorous and pursue opportunistic feeding strategies. Small mammals and edible plant material were the most important food resources for red foxes and raccoon dogs. Nonetheless, interspecies differences were recorded for edible plant material, small mammals and insects. While red foxes mostly feed on voles, raccoon dogs consumed mice and shrews as often as voles. Only raccoon dogs preyed on amphibians. There were no differences in carrion consumption, both species scavenged on wild boar and we found clear competition for carrion year-round. Moreover, there was evidence that two red foxes foraged on raccoon dogs and vice versa. The mean annual interspecies diet overlap index was relatively high. The diets determined for raccoon dogs and red foxes were quite similar and a similar food niche breadth was recorded. However, only minor competition is assumed to take place since differences in feeding habits do exist.},
  language  = {en}
}
@article{SchneiderKutzKapsetal.2020,
  author    = {Schneider, Kathleen and Kutz, Anne and Kaps, Hella and Frank, Ulrike},
  title     = {Dysarthria Impact Profile - D},
  series = {Spektrum Patholinguistik},
  journal   = {Spektrum Patholinguistik},
  number    = {12},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-479-1},
  issn      = {1866-9085},
  doi       = {10.25932/publishup-46964},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-469645},
  pages     = {241 -- 246},
  year      = {2020},
  language  = {de}
}
@article{FrankRadtkeNienstedtetal.2021,
  author    = {Frank, Ulrike and Radtke, Julia and Nienstedt, Julie Cl{\"a}re and P{\"o}tter-Nerger, Monika and Sch{\"o}nwald, Beate and Buhmann, Carsten and Gerloff, Christian and Niessen, Almut and Fl{\"u}gel, Till and Koseki, Jana-Christiane and Pflug, Christina},
  title     = {Dysphagia screening in Parkinson's Disease},
  series = {Neurogastroenterology and motility},
  volume    = {33},
  journal   = {Neurogastroenterology and motility},
  number    = {5},
  publisher = {Wiley},
  address   = {Hoboken},
  issn      = {1350-1925},
  doi       = {10.1111/nmo.14034},
  pages     = {8},
  year      = {2021},
  abstract  = {Background Simple water-swallowing screening tools are not predictive of aspiration and dysphagia in patients with Parkinson's Disease (PD). We investigated the diagnostic accuracy of a multi-texture screening tool, the Gugging Swallowing Screen (GUSS) to identify aspiration and dysphagia/penetration in PD patients compared to flexible endoscopic evaluation of swallowing (FEES). Methods Swallowing function was evaluated in 51 PD participants in clinical 'on-medication' state with the GUSS and a FEES examination according to standardized protocols. Inter-rater reliability and convergent validity were determined and GUSS- and FEES-based diet recommendations were compared. Key Results Inter-rater reliability of GUSS ratings was high (r(s) = 0.8; p < 0.001). Aspiration was identified by the GUSS with a sensitivity of 50\%, and specificity of 51.35\% (PPV 28\%, NPV 73\%, LR+ 1.03, LR- 0.97), dysphagia/penetration was identified with 72.97\% sensitivity and 35.71\% specificity (PPV 75\%, NPV 33.33\%, LR+ 1.14, LR- 0.76). Agreement between GUSS- and FEES-based diet recommendations was low (r(s) = 0.12, p = 0.42) with consistent NPO (Nil per Os) allocation by GUSS and FEES in only one participant. Conclusions and Inferences The multi-texture screening tool GUSS in its current form, although applicable with good inter-rater reliability, does not detect aspiration in PD patients with acceptable accuracy. Modifications of the GUSS parameters "coughing," "voice change" and "delayed swallowing" might enhance validity. The GUSS' diet recommendations overestimate the need for oral intake restriction in PD patients and should be verified by instrumental swallowing examination.},
  language  = {en}
}
@misc{FrankRadtkeNienstedtetal.2021,
  author    = {Frank, Ulrike and Radtke, Julia and Nienstedt, Julie Cl{\"a}re and P{\"o}tter-Nerger, Monika and Sch{\"o}nwald, Beate and Buhmann, Carsten and Gerloff, Christian and Niessen, Almut and Fl{\"u}gel, Till and Koseki, Jana-Christiane and Pflug, Christina},
  title     = {Dysphagia screening in Parkinson's Disease},
  series = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe},
  journal   = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe},
  number    = {5},
  issn      = {1866-8364},
  doi       = {10.25932/publishup-56962},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-569625},
  pages     = {10},
  year      = {2021},
  abstract  = {Background Simple water-swallowing screening tools are not predictive of aspiration and dysphagia in patients with Parkinson's Disease (PD). We investigated the diagnostic accuracy of a multi-texture screening tool, the Gugging Swallowing Screen (GUSS) to identify aspiration and dysphagia/penetration in PD patients compared to flexible endoscopic evaluation of swallowing (FEES). Methods Swallowing function was evaluated in 51 PD participants in clinical 'on-medication' state with the GUSS and a FEES examination according to standardized protocols. Inter-rater reliability and convergent validity were determined and GUSS- and FEES-based diet recommendations were compared. Key Results Inter-rater reliability of GUSS ratings was high (r(s) = 0.8; p < 0.001). Aspiration was identified by the GUSS with a sensitivity of 50\%, and specificity of 51.35\% (PPV 28\%, NPV 73\%, LR+ 1.03, LR- 0.97), dysphagia/penetration was identified with 72.97\% sensitivity and 35.71\% specificity (PPV 75\%, NPV 33.33\%, LR+ 1.14, LR- 0.76). Agreement between GUSS- and FEES-based diet recommendations was low (r(s) = 0.12, p = 0.42) with consistent NPO (Nil per Os) allocation by GUSS and FEES in only one participant. Conclusions and Inferences The multi-texture screening tool GUSS in its current form, although applicable with good inter-rater reliability, does not detect aspiration in PD patients with acceptable accuracy. Modifications of the GUSS parameters "coughing," "voice change" and "delayed swallowing" might enhance validity. The GUSS' diet recommendations overestimate the need for oral intake restriction in PD patients and should be verified by instrumental swallowing examination.},
  language  = {en}
}
@article{FrankFrankZimmermann2015,
  author    = {Frank, Ulrike and Frank, Katrin and Zimmermann, Heinrich},
  title     = {Effects of Respiratory Therapy (bagging) on Respiratory Function, Swallowing Frequency and Vigilance in Tracheotomized Patients in Early Neurorehabilitation},
  series = {Pneumologie : Zeitschrift f{\"u}r Pneumologie und Beatmungsmedizin},
  volume    = {69},
  journal   = {Pneumologie : Zeitschrift f{\"u}r Pneumologie und Beatmungsmedizin},
  number    = {7},
  publisher = {Thieme},
  address   = {Stuttgart},
  issn      = {0934-8387},
  doi       = {10.1055/s-0034-1392359},
  pages     = {394 -- 399},
  year      = {2015},
  abstract  = {Objective: Tracheotomized patients often suffer from impairments in mucociliary clearance and limited capacities for active expectoration of secretions. We investigated the effects of a specific respiratory intervention method (bagging) for tracheotomized patients on respiratory parameters (pO(2), pCO(2), SpO(2), respiratory rates), swallowing frequency, vigilance and secretion viscosity. Methods: The bagging method supports enforced mobilization and expectoration of secretions by application of a series of manual hyperinflations with a resuscitation bag during active inspiration and manual cough support on the chest. 30 tracheotomized neurological patients participated in a multiple-baseline study including a three-weeks intervention period and a follow-up measurement three weeks after termination of the treatment. Results: Most outcome parameters improved significantly during the intervention period: pO(2) (p<.01), SpO(2) (p<.01), respiratory rates (p<.01), swallowing rates (p<.01), and vigilance scores (p<.01). The quality of bronchial secretions improved in all participants. All effects were sustained up to the follow-up measurements. Conclusion: This preliminary data indicates positive effects for a respiratory intervention method (bagging) on respiratory function and additional respiration-related functions in tracheotomized neurological patients. This easy-to-learn and inexpensive method might expand the range of treatment options for tracheotomized and non-responsive patients.},
  language  = {en}
}