@misc{KlannDeliusKauschkeGluecketal.2008, author = {Klann-Delius, Gisela and Kauschke, Christina and Gl{\"u}ck, Christian W. and Schr{\"o}der, Astrid and Lorenz, Antje and Domahs, Frank and Grande, Marion and Domahs, Ulrike and Frankenberg, Jenny v. and Wahl, Michael and De Kok, D{\"o}rte and Stadie, Nicole and Machleb, Franziska and Manz, Katrin and Frank, Ulrike and Sperlich, Kathrin and Vauth, Friederike and Hampel, Pamela and M{\"a}der, Mark and Sticher, Heike and Bethmann, Anja and Fischenich, Andrea and Scheich, Henning and Brechmann, Andr{\´e} and Peschke, Claudia and Ziegler, Wolfram and Kappes, Juliane and Baumg{\"a}rtner, Annette and Sonntag, Kristin and Bartels, Luise and Heide, Judith and Meinunger, Andr{\´e} and Burchert, Frank and Bohn, Christiane and Kliegl, Reinhold and Gottal, Stephanie and Berendes, Karin and Grabherr, Britta and Schneeberg, Jennifer and Wittler, Marion and Ptok, Martin and Sallat, Stephan}, title = {Spektrum Patholinguistik = Schwerpunktthema: der Erwerb von Lexikon und Semantik: Meilensteine, St{\"o}rungen und Therapie ; Tagungsband zum 1. Herbsttreffen Patholinguistik, 24. November 2007}, number = {1}, editor = {Wahl, Michael and Michael, Judith and Hanne, Sandra}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, organization = {Verband f{\"u}r Patholinguistik e. V. (vpl)}, issn = {1869-3822}, doi = {10.25932/publishup-1719}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-18688}, year = {2008}, abstract = {Der vorliegende Tagungsband enth{\"a}lt alle Beitr{\"a}ge des 1. Herbsttreffens Patholinguistik, das am 24.11.2007 an der Universit{\"a}t Potsdam stattgefunden hat. Sowohl die drei Hauptvortr{\"a}ge zum Thema „Der Erwerb von Lexikon und Semantik - Meilensteine, St{\"o}rungen und Therapie" als auch die Kurzvortr{\"a}ge promovierter Patholinguisten sind ausf{\"u}hrlich dokumentiert. Außerdem enth{\"a}lt der Tagungsband die Abstracts der pr{\"a}sentierten Poster.}, language = {de} } @misc{AichertStaigerSchulteMaeteretal.2010, author = {Aichert, Ingrid and Staiger, Anja and Schulte-M{\"a}ter, Anne and Becker-Redding, Ulrike and Stahn, Corinna and Peschke, Claudia and Heide, Judith and Ott, Susan and Herrmann, Heike and V{\"o}lsch, Juliane and Mayer, J{\"o}rg and Rohnke, Lucie and Frank, Ulrike and Stadie, Nicole and Jentsch, Nadine and Blech, Anke and Kurtenbach, Stephanie and Thieke, Johanna and Schr{\"o}der, Astrid and Stahn, Corinna and H{\"o}rnig, Robin and Burchert, Frank and De Bleser, Ria and Heister, Julian and Bartels, Luise and W{\"u}rzner, Kay-Michael and B{\"o}hme, Romy and Burmester, Juliane and Krajewski, Melanie and Nager, Wido and Jungeh{\"u}lsing, Gerhard Jan and Wartenburger, Isabell and J{\"o}bges, Michael and Schwilling, Eleonore and Lidzba, Karen and Winkler, Susanne and Konietzko, Andreas and Kr{\"a}geloh-Mann, Ingeborg and Rilling, Eva and Wilken, Rainer and Wismann, Kathrin and Glandorf, Birte and Hoffmann, Hannah and Hinnenkamp, Christiane and Rohlmann, Insa and Ludewigt, Jacqueline and Bittner, Christian and Orlov, Tatjana and Claus, Katrin and Ehemann, Christine and Winnecken, Andreas and Hummel, Katja and Breitenstein, Sarah}, title = {Spektrum Patholinguistik = Schwerpunktthema: Von der Programmierung zur Artikulation : Sprechapraxie bei Kindern und Erwachsenen}, number = {3}, editor = {Wahl, Michael and Stahn, Corinna and Hanne, Sandra and Fritzsche, Tom}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, organization = {Verband f{\"u}r Patholinguistik e. V. (vpl)}, isbn = {978-3-86956-079-3}, issn = {1869-3822}, doi = {10.25932/publishup-4578}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-45470}, year = {2010}, abstract = {Das 3. Herbsttreffen Patholinguistik fand am 21. November 2009 an der Universit{\"a}t Potsdam statt. Der vorliegende Tagungsband enth{\"a}lt die drei Hauptvortr{\"a}ge zum Schwerpunktthema „Von der Programmierung zu Artikulation: Sprechapraxie bei Kindern und Erwachsenen". Dar{\"u}ber hinaus enth{\"a}lt der Band die Beitr{\"a}ge aus dem Spektrum Patholinguistik, sowie die Abstracts der Posterpr{\"a}sentationen.}, language = {de} } @misc{CorstenGuentherNieslonyetal.2016, author = {Corsten, Sabine and G{\"u}nther, Thomas and Nieslony, Julia and Fl{\"o}ther, Manfred and Rott, Anke and Sch{\"o}ppe, Doreen and K{\"o}sterke-Buchardt, Antje and Machleb, Franziska and Purat, Patricia and Euler, Harald A. and Breitenstein, Sarah and D{\"u}sterh{\"o}ft, Stefanie and Posse, Dorothea and Topaj, Nathalie and Golcher, Felix and Gagarina, Natalʹja Vladimirovna and Stegenwallner-Sch{\"u}tz, Maja Henny Katherine and Lassotta, Romy and Ferchland, Lisa and Adani, Flavia and Wotschack, Christiane and Klassert, Annegret and Festman, Julia and Schumacher, Rebecca and Burchert, Frank and Ablinger, Irene and Buttler, Rahel and Frank, Luis and Stadie, Nicole and Weiland, Linda and Netzebandt, Jonka and Frank, Ulrike and Bykova, Ksenia and Loppnow, Anna and Huckabee, Maggie-Lee and Krusche, Lisa}, title = {Spektrum Patholinguistik Band 9. Schwerpunktthema: Lauter Laute: Phonologische Verarbeitung und Lautwahrnehmung in der Sprachtherapie}, series = {Spektrum Patholinguistik}, journal = {Spektrum Patholinguistik}, editor = {Fritzsche, Tom and Yetim, {\"O}zlem and Otto, Constanze and Adelt, Anne}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-385-5}, issn = {1866-9085}, doi = {10.25932/publishup-9665}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-96653}, pages = {vi, 269}, year = {2016}, abstract = {Das 9. Herbsttreffen Patholinguistik mit dem Schwerpunktthema "Lauter Laute: Phonologische Verarbeitung und Lautwahrnehmung in der Sprachtherapie" fand am 14.11.2015 in Potsdam statt. Das Herbsttreffen wird seit 2007 j{\"a}hrlich vom Verband f{\"u}r Patholinguistik e.V. (vpl) durchgef{\"u}hrt. Der vorliegende Tagungsband beinhaltet die vier Hauptvortr{\"a}ge zum Schwerpunktthema, die drei Kurzvortr{\"a}ge aus dem Spektrum Patholinguisitk sowie die Beitr{\"a}ge der Posterpr{\"a}sentationen zu weiteren Themen aus der sprachtherapeutischen Forschung und Praxis.}, language = {de} } @misc{VoigtZimmermannStierLascheitetal.2019, author = {Voigt-Zimmermann, Susanne and Stier, Karl-Heinz and Lascheit, Thomas and Kruse, Stephanie A. and Blickensdorff, Maria and F{\"o}rster, Theresa and Schumacher, Rebecca and Burchert, Frank and Ablinger, Irene and F{\"o}rster, Christine and Wahl, Michael and Schirmacher, Irene and Ostermann, Frank and Welke, Lisa-Marie and Frank, Ulrike and Zakari{\´a}s, Lilla and Salis, Christos and Wartenburger, Isabell and Krug, Ragna and St{\"u}bner, Hanna and Hoffmann, Sophie and Heide, Judith}, title = {Spektrum Patholinguistik Band 11. Schwerpunktthema: Gut gestimmt: Diagnostik und Therapie bei Dysphonie}, number = {11}, editor = {Fritzsche, Tom and Yetim, {\"O}zlem and Otto, Constanze and Adelt, Anne}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-448-7}, issn = {1866-9085}, doi = {10.25932/publishup-41857}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-418574}, pages = {142}, year = {2019}, abstract = {Das 11. Herbsttreffen Patholinguistik mit dem Schwerpunktthema »Gut gestimmt: Diagnostik und Therapie bei Dysphonie« fand am 18.11.2017 in Potsdam statt. Das Herbsttreffen wird seit 2007 j{\"a}hrlich vom Verband f{\"u}r Patholinguistik e.V. (vpl) durchgef{\"u}hrt. Der vorliegende Tagungsband beinhaltet die Hauptvortr{\"a}ge zum Schwerpunktthema sowie Beitr{\"a}ge zu den Kurzvortr{\"a}gen »Spektrum Patholinguistik« und der Posterpr{\"a}sentationen zu weiteren Themen aus der sprachtherapeutischen Forschung und Praxis.}, language = {de} } @misc{AktasSuccowGieletal.2015, author = {Aktas, Maren and Succow, Juliane and Giel, Barbara and Dressel, Katharina and Lange, Inga and Hanne, Sandra and Burchert, Frank and Vasishth, Shravan and Schwytay, Jeannine and Breitenstein, Sarah and Fleischhauer, Elisabeth and Baumann, Jeannine and Preisinger, Irmhild and Siegm{\"u}ller, Julia and Kuschmann, Anja and Ebert, Susanne and Lowit, Anja and Rath, Elisa and Heide, Judith and Lorenz, Antje and Wartenburger, Isabell and Hippeli, Carolin and Rausch, Monika and W{\"u}rzner, Kay-Michael and Schroeder, Sascha and Czapka, Sophia and Klassert, Annegret and Reuters, Sabine and Frank, Ulrike and Frank, Katrin and Zimmermann, Heinrich and Peiffers, Sabine and Thonicke, Mady}, title = {Spektrum Patholinguistik = Schwerpunktthema: Besonders behandeln? : Sprachtherapie im Rahmen prim{\"a}rer St{\"o}rungsbilder}, number = {8}, editor = {Adelt, Anne and Otto, Constanze and Fritzsche, Tom and Magister, Caroline}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, organization = {Verband f{\"u}r Patholinguistik e. V. (vpl)}, isbn = {978-3-86956-335-0}, issn = {1869-3822}, doi = {10.25932/publishup-7714}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-77147}, pages = {vii, 247}, year = {2015}, abstract = {Das 8. Herbsttreffen Patholinguistik mit dem Schwerpunktthema "Besonders behandeln? Sprachtherapie im Rahmen prim{\"a}rer St{\"o}rungsbilder" fand am 15.11.2014 in Potsdam statt. Das Herbsttreffen wird seit 2007 j{\"a}hrlich vom Verband f{\"u}r Patholinguistik e.V. (vpl) durchgef{\"u}hrt. Der vorliegende Tagungsband beinhaltet die vier Hauptvortr{\"a}ge zum Schwerpunktthema, die vier Kurzvortr{\"a}ge aus dem Spektrum Patholinguisitk sowie die Beitr{\"a}ge der Posterpr{\"a}sentationen zu weiteren Themen aus der sprachtherapeutischen Forschung und Praxis.}, language = {de} } @article{NeuschaeferRubeOppermannMoelleretal.1999, author = {Neusch{\"a}fer-Rube, Frank and Oppermann, Martin and M{\"o}ller, Ulrike and B{\"o}er, Ulrike and P{\"u}schel, Gerhard Paul}, title = {Agonist-induced phosphorylation by G protein-coupled receptor kinases of the EP4 receptor carboxyl-terminal domain in an EP3/EP4 prostaglandin E(2) receptor hybrid}, issn = {1521-0111}, year = {1999}, abstract = {Prostaglandin E(2) receptors (EP-Rs) belong to the family of heterotrimeric G protein-coupled ectoreceptors with seven transmembrane domains. They can be subdivided into four subtypes according to their ligand-binding and G protein-coupling specificity: EP1 couple to G(q), EP2 and EP4 to G(s), and EP3 to G(i). The EP4-R, in contrast to the EP3beta-R, shows rapid agonist-induced desensitization. The agonist-induced desensitization depends on the presence of the EP4-R carboxyl-terminal domain, which also confers desensitization in a G(i)-coupled rEP3hEP4 carboxyl-terminal domain receptor hybrid (rEP3hEP4-Ct-R). To elucidate the possible mechanism of this desensitization, in vivo phosphorylation stimulated by activators of second messenger kinases, by prostaglandin E(2), or by the EP3-R agonist M\&B28767 was investigated in COS-7 cells expressing FLAG-epitope-tagged rat EP3beta-R (rEP3beta-R), hEP4-R, or rEP3hEP4- Ct-R. Stimulation of protein kinase C with phorbol-12-myristate-13-acetate led to a slight phosphorylation of the FLAG- rEP3beta-R but to a strong phosphorylation of the FLAG-hEP4-R and the FLAG-rEP3hEP4-Ct-R, which was suppressed by the protein kinase A and protein kinase C inhibitor staurosporine. Prostaglandin E(2) stimulated phosphorylation of the FLAG- hEP4-R in its carboxyl-terminal receptor domain. The EP3-R agonist M\&B28767 induced a time- and dose-dependent phosphorylation of the FLAG-rEP3hEP4-Ct-R but not of the FLAG-rEP3beta-R. Agonist-induced phosphorylation of the FLAG- hEP4-R and the FLAG-rEP3hEP4-Ct-R were not inhibited by staurosporine, which implies a role of G protein-coupled receptor kinases (GRKs) in agonist-induced receptor phosphorylation. Overexpression of GRKs in FLAG-rEP3hEP4-Ct-R- expressing COS-7 cells augmented the M\&B28767-induced receptor phosphorylation and receptor sequestration. These findings indicate that phosphorylation of the carboxyl-terminal hEP4-R domain possibly by GRKs but not by second messenger kinases may be involved in rapid agonist-induced desensitization of the hEP4-R and the rEP3hEP4-Ct-R.}, language = {en} } @article{BoeerNeuschaeferRubeMoelleretal.2000, author = {B{\"o}er, Ulrike and Neusch{\"a}fer-Rube, Frank and M{\"o}ller, Ulrike and P{\"u}schel, Gerhard Paul}, title = {Requirement of N-glycosylation of the prostaglandin E2 receptor EP3beta for correct sorting to the plasma membrane but not for correct folding}, year = {2000}, abstract = {Eight heptahelical receptors have been characterized for prostaglandin (PG) D(2), PGE(2), PGF(2alpha), prostacyclin and thromboxane A(2). They share a sequence identity of 40\%. All of them have potential N-glycosylation sites. The current study analysed the role of the two N-glycosylation sites in the rat EP3beta-subtype PGE(2) receptor for protein folding and sorting. The N-glycosylation consensus sequences were eliminated by site-directed mutagenesis and receptors expressed in HEK-293 cells. Both potential N-glycosylation sites were used. Their joint elimination resulted in the synthesis of a receptor protein with full binding competence, biological activity and no reduction of affinity; however, the half-life of the non-glycosylated receptor was slightly reduced. Ligand binding to intact stably transfected cells and confocal laser microscopic immunocytochemistry showed that the glycosylated receptor was correctly inserted into the plasma membrane to a much larger extent than the non-glycosylated receptor, which tended to accumulate in the perinuclear zone of the endoplasmic reticulum. Inhibition of N-glycosylation with tunicamycin resulted in a similar perinuclear distribution of the wild-type receptor. Therefore, glycosylation of the EP3beta receptor seems not to be necessary for correct folding of the receptor protein but for the efficient transport of the receptor protein to the plasma membrane. This contrasts with a previous finding which described a reduction of the affinity for PGE(2) of the EP3alpha receptor by elimination of the distal glycosylation site when the receptor protein was expressed in insect cells.}, language = {en} } @article{GaeckleDomahsKartmannetal.2019, author = {Gaeckle, Maren and Domahs, Frank and Kartmann, Angelika and Tomandl, Bernd and Frank, Ulrike}, title = {Predictors of Penetration-Aspiration in Parkinson's Disease Patients With Dysphagia}, series = {Annals of Otology, Rhinology and Laryngology}, volume = {128}, journal = {Annals of Otology, Rhinology and Laryngology}, number = {8}, publisher = {Sage Publ.}, address = {Thousand Oaks}, issn = {0003-4894}, doi = {10.1177/0003489419841398}, pages = {728 -- 735}, year = {2019}, abstract = {Methods: The data of 89 PD patients with dysphagia who underwent routinely conducted videofluoroscopic studies of swallowing (VFSS) were included in this retrospective study. The occurrence of penetration-aspiration was defined as scores >= 3 on the Penetration-Aspiration Scale (PAS). Four commonly reported signs of dysphagia in PD patients were evaluated as possible predictors. Furthermore, the relationships between the occurrence of penetration-aspiration and liquid bolus volume as well as clinical severity of PD (modified Hoehn and Yahr scale) were examined. Results: Logistic regression showed that a delayed initiation of the pharyngeal swallow (odds ratio [OR] = 7.47, P = .008) and a reduced hyolaryngeal excursion (OR = 5.13, P = .012) were predictors of penetration-aspiration. Moreover, there was a strong, positive correlation between increasing liquid bolus volume and penetration-aspiration (gamma = 0.71, P < .001). No correlation was found between severity of PD and penetration-aspiration (gamma = 0.077, P = .783). Conclusion: Results of the present study allow for a better understanding of penetration-aspiration risk in PD patients. They are useful for treatment planning in order to improve safe oral intake and adequate nutrition.}, language = {en} } @article{FrankFrankZimmermann2015, author = {Frank, Ulrike and Frank, Katrin and Zimmermann, Heinrich}, title = {Effekte einer spezifischen Atemtherapie (Bagging) auf die Atem- und Schluckfunktion bei tracheotomierten Patienten}, series = {Spektrum Patholinguistik (Band 8) - Schwerpunktthema: Besonders behandeln? : Sprachtherapie im Rahmen prim{\"a}rer St{\"o}rungsbilder}, journal = {Spektrum Patholinguistik (Band 8) - Schwerpunktthema: Besonders behandeln? : Sprachtherapie im Rahmen prim{\"a}rer St{\"o}rungsbilder}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-79873}, pages = {235 -- 237}, year = {2015}, language = {de} } @article{FrankFrank2022, author = {Frank, Ulrike and Frank, Katrin}, title = {COVID-19}, series = {Der Nervenarzt : Organ der Deutschen Gesellschaft f{\"u}r Psychiatrie, Psychotherapie und Nervenheilkunde ; Mitteilungsblatt der Deutschen Gesellschaft f{\"u}r Neurologie}, volume = {93}, journal = {Der Nervenarzt : Organ der Deutschen Gesellschaft f{\"u}r Psychiatrie, Psychotherapie und Nervenheilkunde ; Mitteilungsblatt der Deutschen Gesellschaft f{\"u}r Neurologie}, number = {2}, publisher = {Springer}, address = {New York}, issn = {0028-2804}, doi = {10.1007/s00115-021-01162-5}, pages = {167 -- 174}, year = {2022}, abstract = {Eine COVID-19-Erkrankung kann zu schweren Krankheitsverl{\"a}ufen mit multiplen Organbeteiligungen und respiratorischen und neurologischen Funktionseinschr{\"a}nkungen f{\"u}hren. Schluckst{\"o}rungen (Dysphagien) k{\"o}nnen in dieser Patientengruppe durch prim{\"a}re Sch{\"a}digungen des zentralen und peripheren neuronalen Netzwerkes der Schluckfunktion entstehen, aber auch bedingt durch die h{\"a}ufig l{\"a}ngere intensivmedizinische Behandlung und Beatmung. Erste klinische Befunde zeigen persistierende Dysphagien im Rahmen des Post-COVID-Syndroms („Long-COVID"), sodass die Patienten auch l{\"a}ngerfristige Maßnahmen zur Rehabilitation einer sicheren und suffizienten oralen Nahrungsaufnahme ben{\"o}tigen. Daher sollte in die Behandlung von COVID-19-Patienten ein strukturiertes erkrankungsspezifisches Monitoring in Bezug auf Dysphagiesymptome integriert werden, und atemtherapeutische Maßnahmen zur Regulation von Husteneffektivit{\"a}t und Atem-Schluck-Koordination sollten auch bei diesen Patienten essenzieller Bestandteil des Dysphagiemanagements sein. Herausforderungen ergeben sich dabei einerseits durch die erforderlichen Anpassungen etablierter Behandlungsstandards an den Infektionsschutz. Zudem m{\"u}ssen Auswahl und Durchf{\"u}hrungsintensit{\"a}t therapeutischer Maßnahmen an die Kapazit{\"a}ten und die spezifische Pathophysiologie der COVID-19- und Long-COVID-Patienten angepasst werden, um weitere funktionelle Verschlechterungen zu vermindern.}, language = {de} } @article{SchlickeweiNienstedtFranketal.2021, author = {Schlickewei, Ole and Nienstedt, Julie Cl{\"a}re and Frank, Ulrike and Fr{\"u}ndt, Odette and P{\"o}tter-Nerger, Monika and Gerloff, Christian and Buhmann, Carsten and M{\"u}ller, Frank and Lezius, Susanne and Koseki, Jana-Christiane and Pflug, Christina}, title = {The ability of the eating assessment tool‑10 to detect penetration and aspiration in Parkinson's disease}, series = {European archives of oto-rhino-laryngology and head \& neck}, volume = {278}, journal = {European archives of oto-rhino-laryngology and head \& neck}, number = {5}, publisher = {Springer}, address = {Berlin}, issn = {0937-4477}, doi = {10.1007/s00405-020-06377-x}, pages = {1661 -- 1668}, year = {2021}, abstract = {Purpose: Dysphagia is common in patients with Parkinson's disease (PD) and often leads to pneumonia, malnutrition, and reduced quality of life. This study investigates the ability of the Eating Assessment Tool-10 (EAT-10), an established, easy self-administered screening tool, to detect aspiration in PD patients. This study aims to validate the ability of the EAT-10 to detect FEES-proven aspiration in patients with PD. Methods: In a controlled prospective cross-sectional study, a total of 50 PD patients completed the EAT-10 and, subsequently, were examined by Flexible Endoscopic Evaluation of Swallowing (FEES) to determine the swallowing status. The results were rated through the Penetration-Aspiration Scale (PAS) and data were analyzed retrospectively. Results: PAS and EAT-10 did not correlate significantly. Selected items of the EAT-10 could not predict aspiration or residues. 19 (38\%) out of 50 patients with either penetration or aspiration were not detected by the EAT-10. The diagnostic accuracy was established at only a sufficient level (AUC 0.65). An optimal cut-off value of >= 6 presented a sensitivity of 58\% and specificity of 82\%. Conclusions: The EAT-10 is not suited for the detection of penetration and aspiration in PD patients. Therefore, it cannot be used as a screening method in this patient population. There is still a need for a valid, simple, and efficient screening tool to assist physicians in their daily diagnostics and to avoid clinical complications.}, language = {en} } @article{FrankFrankZimmermann2015, author = {Frank, Ulrike and Frank, Katrin and Zimmermann, Heinrich}, title = {Effects of Respiratory Therapy (bagging) on Respiratory Function, Swallowing Frequency and Vigilance in Tracheotomized Patients in Early Neurorehabilitation}, series = {Pneumologie : Zeitschrift f{\"u}r Pneumologie und Beatmungsmedizin}, volume = {69}, journal = {Pneumologie : Zeitschrift f{\"u}r Pneumologie und Beatmungsmedizin}, number = {7}, publisher = {Thieme}, address = {Stuttgart}, issn = {0934-8387}, doi = {10.1055/s-0034-1392359}, pages = {394 -- 399}, year = {2015}, abstract = {Objective: Tracheotomized patients often suffer from impairments in mucociliary clearance and limited capacities for active expectoration of secretions. We investigated the effects of a specific respiratory intervention method (bagging) for tracheotomized patients on respiratory parameters (pO(2), pCO(2), SpO(2), respiratory rates), swallowing frequency, vigilance and secretion viscosity. Methods: The bagging method supports enforced mobilization and expectoration of secretions by application of a series of manual hyperinflations with a resuscitation bag during active inspiration and manual cough support on the chest. 30 tracheotomized neurological patients participated in a multiple-baseline study including a three-weeks intervention period and a follow-up measurement three weeks after termination of the treatment. Results: Most outcome parameters improved significantly during the intervention period: pO(2) (p<.01), SpO(2) (p<.01), respiratory rates (p<.01), swallowing rates (p<.01), and vigilance scores (p<.01). The quality of bronchial secretions improved in all participants. All effects were sustained up to the follow-up measurements. Conclusion: This preliminary data indicates positive effects for a respiratory intervention method (bagging) on respiratory function and additional respiration-related functions in tracheotomized neurological patients. This easy-to-learn and inexpensive method might expand the range of treatment options for tracheotomized and non-responsive patients.}, language = {en} } @article{vanderValkKreinerMollerKooijmanetal.2015, author = {van der Valk, Ralf J. P. and Kreiner-Moller, Eskil and Kooijman, Marjolein N. and Guxens, Monica and Stergiakouli, Evangelia and Saaf, Annika and Bradfield, Jonathan P. and Geller, Frank and Hayes, M. Geoffrey and Cousminer, Diana L. and Koerner, Antje and Thiering, Elisabeth and Curtin, John A. and Myhre, Ronny and Huikari, Ville and Joro, Raimo and Kerkhof, Marjan and Warrington, Nicole M. and Pitkanen, Niina and Ntalla, Ioanna and Horikoshi, Momoko and Veijola, Riitta and Freathy, Rachel M. and Teo, Yik-Ying and Barton, Sheila J. and Evans, David M. and Kemp, John P. and St Pourcain, Beate and Ring, Susan M. and Smith, George Davey and Bergstrom, Anna and Kull, Inger and Hakonarson, Hakon and Mentch, Frank D. and Bisgaard, Hans and Chawes, Bo Lund Krogsgaard and Stokholm, Jakob and Waage, Johannes and Eriksen, Patrick and Sevelsted, Astrid and Melbye, Mads and van Duijn, Cornelia M. and Medina-Gomez, Carolina and Hofman, Albert and de Jongste, Johan C. and Taal, H. Rob and Uitterlinden, Andre G. and Armstrong, Loren L. and Eriksson, Johan and Palotie, Aarno and Bustamante, Mariona and Estivill, Xavier and Gonzalez, Juan R. and Llop, Sabrina and Kiess, Wieland and Mahajan, Anubha and Flexeder, Claudia and Tiesler, Carla M. T. and Murray, Clare S. and Simpson, Angela and Magnus, Per and Sengpiel, Verena and Hartikainen, Anna-Liisa and Keinanen-Kiukaanniemi, Sirkka and Lewin, Alexandra and Alves, Alexessander Da Silva Couto and Blakemore, Alexandra I. F. and Buxton, Jessica L. and Kaakinen, Marika and Rodriguez, Alina and Sebert, Sylvain and Vaarasmaki, Marja and Lakka, Timo and Lindi, Virpi and Gehring, Ulrike and Postma, Dirkje S. and Ang, Wei and Newnham, John P. and Lyytikainen, Leo-Pekka and Pahkala, Katja and Raitakari, Olli T. and Panoutsopoulou, Kalliope and Zeggini, Eleftheria and Boomsma, Dorret I. and Groen-Blokhuis, Maria and Ilonen, Jorma and Franke, Lude and Hirschhorn, Joel N. and Pers, Tune H. and Liang, Liming and Huang, Jinyan and Hocher, Berthold and Knip, Mikael and Saw, Seang-Mei and Holloway, John W. and Melen, Erik and Grant, Struan F. A. and Feenstra, Bjarke and Lowe, William L. and Widen, Elisabeth and Sergeyev, Elena and Grallert, Harald and Custovic, Adnan and Jacobsson, Bo and Jarvelin, Marjo-Riitta and Atalay, Mustafa and Koppelman, Gerard H. and Pennell, Craig E. and Niinikoski, Harri and Dedoussis, George V. and Mccarthy, Mark I. and Frayling, Timothy M. and Sunyer, Jordi and Timpson, Nicholas J. and Rivadeneira, Fernando and Bonnelykke, Klaus and Jaddoe, Vincent W. V.}, title = {A novel common variant in DCST2 is associated with length in early life and height in adulthood}, series = {Human molecular genetics}, volume = {24}, journal = {Human molecular genetics}, number = {4}, publisher = {Oxford Univ. Press}, address = {Oxford}, organization = {Early Genetics Lifecourse, Genetic Invest ANthropometric, Early Growth Genetics EGG}, issn = {0964-6906}, doi = {10.1093/hmg/ddu510}, pages = {1155 -- 1168}, year = {2015}, abstract = {Common genetic variants have been identified for adult height, but not much is known about the genetics of skeletal growth in early life. To identify common genetic variants that influence fetal skeletal growth, we meta-analyzed 22 genome-wide association studies (Stage 1; N = 28 459). We identified seven independent top single nucleotide polymorphisms (SNPs) (P < 1 x 10(-6)) for birth length, of which three were novel and four were in or near loci known to be associated with adult height (LCORL, PTCH1, GPR126 and HMGA2). The three novel SNPs were followed-up in nine replication studies (Stage 2; N = 11 995), with rs905938 in DC-STAMP domain containing 2 (DCST2) genome-wide significantly associated with birth length in a joint analysis (Stages 1 + 2; beta = 0.046, SE = 0.008, P = 2.46 x 10(-8), explained variance = 0.05\%). Rs905938 was also associated with infant length (N = 28 228; P = 5.54 x 10(-4)) and adult height (N = 127 513; P = 1.45 x 10(-5)). DCST2 is a DC-STAMP-like protein family member and DC-STAMP is an osteoclast cell-fusion regulator. Polygenic scores based on 180 SNPs previously associated with human adult stature explained 0.13\% of variance in birth length. The same SNPs explained 2.95\% of the variance of infant length. Of the 180 known adult height loci, 11 were genome-wide significantly associated with infant length (SF3B4, LCORL, SPAG17, C6orf173, PTCH1, GDF5, ZNFX1, HHIP, ACAN, HLA locus and HMGA2). This study highlights that common variation in DCST2 influences variation in early growth and adult height.}, language = {en} } @misc{TracyHeideWahletal.2009, author = {Tracy, Rosemarie and Heide, Judith and Wahl, Michael and Triarchi-Herrmann, Vassilia and Grimm, Angela and Wotschack, Christiane and Kulik, Sylvia and Frank, Ulrike and Klassert, Annegret and Gagarina, Natalʹja Vladimirovna and Kauschke, Christina and Eicher, Iris and Tsakmaki, Barbara and Akkaya, Zeynep and Castillo, Esmeralda and Groba, Agnes and H{\"o}hle, Barbara and Miertsch, Barbara and Hubert, Anja and Sauerland, Uli and Schr{\"o}der, Caroline and Stadie, Nicole and Wittler, Marion and Berendes, Karin and Gottal, Stephanie and Grabherr, Britta and Zaps, Jennifer and Ptok, Martin and Hanne, Sandra and Sekerina, Irina A. and Vasishth, Shravan and Burchert, Frank and De Bleser, Ria and Kleissendorf, Barbara and Jaecks, Petra and Stenneken, Prisca and Fischer, Ivette and Moedebeck, Petra}, title = {Spektrum Patholinguistik = Schwerpunktthema: Ein Kopf - Zwei Sprachen : Mehrsprachigkeit in Forschung und Therapie}, number = {2}, editor = {Heide, Judith and Hanne, Sandra and Brandt-Kobele, Oda-Christina and Fritzsche, Tom}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, organization = {Verband f{\"u}r Patholinguistik e. V. (vpl)}, isbn = {978-3-940793-89-8}, issn = {1869-3822}, doi = {10.25932/publishup-3086}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-30451}, year = {2009}, abstract = {"Spektrum Patholinguistik" (Band 2) ist der Tagungsband zum 2. Herbsttreffen Patholinguistik, das der Verband f{\"u}r Patholinguistik (vpl) e.V. am 22.11.2008 an der Universit{\"a}t Potsdam veranstaltet hat. Zum Schwerpunktthema "Ein Kopf - Zwei Sprachen: Mehrsprachigkeit in Forschung und Therapie" sind die drei Hauptvortr{\"a}ge und vier Abstracts von Posterpr{\"a}sentationen ver{\"o}ffentlicht. Desweiteren enth{\"a}lt der Tagungsband freie Beitr{\"a}ge, u.a. zu Satzverarbeitung und Agrammatismus, Lesestrategien und LRS, Prosodie-Entwicklung, kindlichen Aphasien, Dysphagie-Therapie sowie zu kognitiven Defiziten bei {\"a}lteren Menschen.}, language = {de} } @misc{FrankFrankMohretal.2022, author = {Frank, Ulrike and Frank, Katrin and Mohr, Bettina and Kurtenbach, Stephanie and Khader-Lindholz, Aischa and Sallat, Stephan and Wagner, Lilli and D{\"u}ring, Sarah and Lubitz, Anika and Schnelle, Kirsten and Klitsch, Julia and Netzebandt, Jonka and Fritsche, Tom and Uhlemann, Charlotte and Wartenburger, Isabell and Hilton, Matt and Neitzel, Isabel and Schmidt, Johanna and Eikerling, Maren and Cholin, Joana and Menze, Clara and Stadie, Nicole and Schmitz-Antonischki, Dorit and Heide, Judith and Plath, Almut and Corsten, Sabine and Hoffmann, Marie and Leinweber, Juliane and Spelter, Bianca and Karstens, Sven}, title = {Spektrum Patholinguistik Band 15. Schwerpunktthema: Interdisziplin{\"a}r behandeln - Multiprofessionelle Zusammenarbeit in der Sprachtherapie}, series = {Spektrum Patholinguistik}, journal = {Spektrum Patholinguistik}, number = {15}, editor = {Tan, Sarah and D{\"u}ring, Sarah and Wilde, Alina and Wunderlich, Hanna and Fritzsche, Tom}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-542-2}, issn = {1866-9433}, doi = {10.25932/publishup-55820}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-558206}, pages = {vii, 180}, year = {2022}, abstract = {Das 15. Herbsttreffen Patholinguistik mit dem Schwerpunktthema »Interdisziplin{\"a}r (be-)handeln - Multiprofessionelle Zusammenarbeit in der Sprachtherapie« fand am 20.11.2021 als Online-Veranstaltung statt. Das Herbsttreffen wird seit 2007 j{\"a}hrlich vom Verband f{\"u}r Patholinguistik e.V. (vpl), seit 2021 vom Deutschen Bundesverband f{\"u}r akademische Sprachtherapie und Logop{\"a}die (dbs) in Kooperation mit der Universit{\"a}t Potsdam durchgef{\"u}hrt. Der vorliegende Tagungsband beinhaltet die Vortr{\"a}ge zum Schwerpunktthema und Informationen aus der Podiumsdiskussion sowie die Posterpr{\"a}sentationen zu weiteren Themen aus der sprachtherapeutischen Forschung und Praxis.}, language = {de} } @article{FrankFrank2022, author = {Frank, Ulrike and Frank, Katrin}, title = {Teamwork is it!}, series = {Spektrum Patholinguistik 15}, journal = {Spektrum Patholinguistik 15}, number = {15}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-542-2}, issn = {1866-9433}, doi = {10.25932/publishup-57213}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-572134}, pages = {1 -- 19}, year = {2022}, language = {de} } @article{WelkeFrank2019, author = {Welke, Lisa-Marie and Frank, Ulrike}, title = {Pilotfragebogenstudie zur praktischen Umsetzung und Koordination des Trachealkan{\"u}len-Managements in Berlin und Brandenburg}, series = {Spektrum Patholinguistik}, journal = {Spektrum Patholinguistik}, number = {11}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-448-7}, issn = {1866-9085}, doi = {10.25932/publishup-43778}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-437780}, pages = {115 -- 129}, year = {2019}, language = {de} } @article{WeilandNetzebandtFrank2016, author = {Weiland, Linda and Netzebandt, Jonka and Frank, Ulrike}, title = {Schluckst{\"o}rungen bei HNO-Tumorpatienten}, series = {Spektrum Patholinguistik Band 9. Schwerpunktthema: Lauter Laute: Phonologische Verarbeitung und Lautwahrnehmung in der Sprachtherapie}, journal = {Spektrum Patholinguistik Band 9. Schwerpunktthema: Lauter Laute: Phonologische Verarbeitung und Lautwahrnehmung in der Sprachtherapie}, number = {9}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1866-9085}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-99115}, pages = {219 -- 234}, year = {2016}, abstract = {1. Einleitung, 2. Theoretischer Hintergrund, 3. Fragestellung und Hypothesen, 4. Methoden, 5. Ergebnisse, 6. Diskussion, 7. Literatur}, language = {de} } @article{BykovaFrank2016, author = {Bykova, Ksenia and Frank, Ulrike}, title = {Spielend Lernen}, series = {Spektrum Patholinguistik Band 9. Schwerpunktthema: Lauter Laute: Phonologische Verarbeitung und Lautwahrnehmung in der Sprachtherapie}, journal = {Spektrum Patholinguistik Band 9. Schwerpunktthema: Lauter Laute: Phonologische Verarbeitung und Lautwahrnehmung in der Sprachtherapie}, number = {9}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1866-9085}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-99124}, pages = {235 -- 242}, year = {2016}, abstract = {1. Hintergrund, 2. Das Dysphagia Game, 3. Methode, 4. Ergebnisse, 5. Diskussion, 6. Literatur}, language = {de} } @article{LoppnowNetzebandtFranketal.2016, author = {Loppnow, Anna and Netzebandt, Jonka and Frank, Ulrike and Huckabee, Maggie-Lee}, title = {Skill-Training in der Dysphagietherapie}, series = {Spektrum Patholinguistik Band 9. Schwerpunktthema: Lauter Laute: Phonologische Verarbeitung und Lautwahrnehmung in der Sprachtherapie}, journal = {Spektrum Patholinguistik Band 9. Schwerpunktthema: Lauter Laute: Phonologische Verarbeitung und Lautwahrnehmung in der Sprachtherapie}, number = {9}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1866-9085}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-99139}, pages = {243 -- 258}, year = {2016}, abstract = {1. Einleitung, 2. sEMG-Biofeedback in der Dysphagietherapie, 3. Fragestellung, 4. Methodisches Vorgehen, 5. Ergebnisse, 6. Diskussion, 7. Literatur}, language = {de} }