@misc{KlannDeliusKauschkeGluecketal.2008, author = {Klann-Delius, Gisela and Kauschke, Christina and Gl{\"u}ck, Christian W. and Schr{\"o}der, Astrid and Lorenz, Antje and Domahs, Frank and Grande, Marion and Domahs, Ulrike and Frankenberg, Jenny v. and Wahl, Michael and De Kok, D{\"o}rte and Stadie, Nicole and Machleb, Franziska and Manz, Katrin and Frank, Ulrike and Sperlich, Kathrin and Vauth, Friederike and Hampel, Pamela and M{\"a}der, Mark and Sticher, Heike and Bethmann, Anja and Fischenich, Andrea and Scheich, Henning and Brechmann, Andr{\´e} and Peschke, Claudia and Ziegler, Wolfram and Kappes, Juliane and Baumg{\"a}rtner, Annette and Sonntag, Kristin and Bartels, Luise and Heide, Judith and Meinunger, Andr{\´e} and Burchert, Frank and Bohn, Christiane and Kliegl, Reinhold and Gottal, Stephanie and Berendes, Karin and Grabherr, Britta and Schneeberg, Jennifer and Wittler, Marion and Ptok, Martin and Sallat, Stephan}, title = {Spektrum Patholinguistik = Schwerpunktthema: der Erwerb von Lexikon und Semantik: Meilensteine, St{\"o}rungen und Therapie ; Tagungsband zum 1. Herbsttreffen Patholinguistik, 24. November 2007}, number = {1}, editor = {Wahl, Michael and Michael, Judith and Hanne, Sandra}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, organization = {Verband f{\"u}r Patholinguistik e. V. (vpl)}, issn = {1869-3822}, doi = {10.25932/publishup-1719}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-18688}, year = {2008}, abstract = {Der vorliegende Tagungsband enth{\"a}lt alle Beitr{\"a}ge des 1. Herbsttreffens Patholinguistik, das am 24.11.2007 an der Universit{\"a}t Potsdam stattgefunden hat. Sowohl die drei Hauptvortr{\"a}ge zum Thema „Der Erwerb von Lexikon und Semantik - Meilensteine, St{\"o}rungen und Therapie" als auch die Kurzvortr{\"a}ge promovierter Patholinguisten sind ausf{\"u}hrlich dokumentiert. Außerdem enth{\"a}lt der Tagungsband die Abstracts der pr{\"a}sentierten Poster.}, language = {de} } @misc{AichertStaigerSchulteMaeteretal.2010, author = {Aichert, Ingrid and Staiger, Anja and Schulte-M{\"a}ter, Anne and Becker-Redding, Ulrike and Stahn, Corinna and Peschke, Claudia and Heide, Judith and Ott, Susan and Herrmann, Heike and V{\"o}lsch, Juliane and Mayer, J{\"o}rg and Rohnke, Lucie and Frank, Ulrike and Stadie, Nicole and Jentsch, Nadine and Blech, Anke and Kurtenbach, Stephanie and Thieke, Johanna and Schr{\"o}der, Astrid and Stahn, Corinna and H{\"o}rnig, Robin and Burchert, Frank and De Bleser, Ria and Heister, Julian and Bartels, Luise and W{\"u}rzner, Kay-Michael and B{\"o}hme, Romy and Burmester, Juliane and Krajewski, Melanie and Nager, Wido and Jungeh{\"u}lsing, Gerhard Jan and Wartenburger, Isabell and J{\"o}bges, Michael and Schwilling, Eleonore and Lidzba, Karen and Winkler, Susanne and Konietzko, Andreas and Kr{\"a}geloh-Mann, Ingeborg and Rilling, Eva and Wilken, Rainer and Wismann, Kathrin and Glandorf, Birte and Hoffmann, Hannah and Hinnenkamp, Christiane and Rohlmann, Insa and Ludewigt, Jacqueline and Bittner, Christian and Orlov, Tatjana and Claus, Katrin and Ehemann, Christine and Winnecken, Andreas and Hummel, Katja and Breitenstein, Sarah}, title = {Spektrum Patholinguistik = Schwerpunktthema: Von der Programmierung zur Artikulation : Sprechapraxie bei Kindern und Erwachsenen}, number = {3}, editor = {Wahl, Michael and Stahn, Corinna and Hanne, Sandra and Fritzsche, Tom}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, organization = {Verband f{\"u}r Patholinguistik e. V. (vpl)}, isbn = {978-3-86956-079-3}, issn = {1869-3822}, doi = {10.25932/publishup-4578}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-45470}, year = {2010}, abstract = {Das 3. Herbsttreffen Patholinguistik fand am 21. November 2009 an der Universit{\"a}t Potsdam statt. Der vorliegende Tagungsband enth{\"a}lt die drei Hauptvortr{\"a}ge zum Schwerpunktthema „Von der Programmierung zu Artikulation: Sprechapraxie bei Kindern und Erwachsenen". Dar{\"u}ber hinaus enth{\"a}lt der Band die Beitr{\"a}ge aus dem Spektrum Patholinguistik, sowie die Abstracts der Posterpr{\"a}sentationen.}, language = {de} } @misc{CorstenGuentherNieslonyetal.2016, author = {Corsten, Sabine and G{\"u}nther, Thomas and Nieslony, Julia and Fl{\"o}ther, Manfred and Rott, Anke and Sch{\"o}ppe, Doreen and K{\"o}sterke-Buchardt, Antje and Machleb, Franziska and Purat, Patricia and Euler, Harald A. and Breitenstein, Sarah and D{\"u}sterh{\"o}ft, Stefanie and Posse, Dorothea and Topaj, Nathalie and Golcher, Felix and Gagarina, Natalʹja Vladimirovna and Stegenwallner-Sch{\"u}tz, Maja Henny Katherine and Lassotta, Romy and Ferchland, Lisa and Adani, Flavia and Wotschack, Christiane and Klassert, Annegret and Festman, Julia and Schumacher, Rebecca and Burchert, Frank and Ablinger, Irene and Buttler, Rahel and Frank, Luis and Stadie, Nicole and Weiland, Linda and Netzebandt, Jonka and Frank, Ulrike and Bykova, Ksenia and Loppnow, Anna and Huckabee, Maggie-Lee and Krusche, Lisa}, title = {Spektrum Patholinguistik Band 9. Schwerpunktthema: Lauter Laute: Phonologische Verarbeitung und Lautwahrnehmung in der Sprachtherapie}, series = {Spektrum Patholinguistik}, journal = {Spektrum Patholinguistik}, editor = {Fritzsche, Tom and Yetim, {\"O}zlem and Otto, Constanze and Adelt, Anne}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-385-5}, issn = {1866-9085}, doi = {10.25932/publishup-9665}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-96653}, pages = {vi, 269}, year = {2016}, abstract = {Das 9. Herbsttreffen Patholinguistik mit dem Schwerpunktthema "Lauter Laute: Phonologische Verarbeitung und Lautwahrnehmung in der Sprachtherapie" fand am 14.11.2015 in Potsdam statt. Das Herbsttreffen wird seit 2007 j{\"a}hrlich vom Verband f{\"u}r Patholinguistik e.V. (vpl) durchgef{\"u}hrt. Der vorliegende Tagungsband beinhaltet die vier Hauptvortr{\"a}ge zum Schwerpunktthema, die drei Kurzvortr{\"a}ge aus dem Spektrum Patholinguisitk sowie die Beitr{\"a}ge der Posterpr{\"a}sentationen zu weiteren Themen aus der sprachtherapeutischen Forschung und Praxis.}, language = {de} } @misc{AktasSuccowGieletal.2015, author = {Aktas, Maren and Succow, Juliane and Giel, Barbara and Dressel, Katharina and Lange, Inga and Hanne, Sandra and Burchert, Frank and Vasishth, Shravan and Schwytay, Jeannine and Breitenstein, Sarah and Fleischhauer, Elisabeth and Baumann, Jeannine and Preisinger, Irmhild and Siegm{\"u}ller, Julia and Kuschmann, Anja and Ebert, Susanne and Lowit, Anja and Rath, Elisa and Heide, Judith and Lorenz, Antje and Wartenburger, Isabell and Hippeli, Carolin and Rausch, Monika and W{\"u}rzner, Kay-Michael and Schroeder, Sascha and Czapka, Sophia and Klassert, Annegret and Reuters, Sabine and Frank, Ulrike and Frank, Katrin and Zimmermann, Heinrich and Peiffers, Sabine and Thonicke, Mady}, title = {Spektrum Patholinguistik = Schwerpunktthema: Besonders behandeln? : Sprachtherapie im Rahmen prim{\"a}rer St{\"o}rungsbilder}, number = {8}, editor = {Adelt, Anne and Otto, Constanze and Fritzsche, Tom and Magister, Caroline}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, organization = {Verband f{\"u}r Patholinguistik e. V. (vpl)}, isbn = {978-3-86956-335-0}, issn = {1869-3822}, doi = {10.25932/publishup-7714}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-77147}, pages = {vii, 247}, year = {2015}, abstract = {Das 8. Herbsttreffen Patholinguistik mit dem Schwerpunktthema "Besonders behandeln? Sprachtherapie im Rahmen prim{\"a}rer St{\"o}rungsbilder" fand am 15.11.2014 in Potsdam statt. Das Herbsttreffen wird seit 2007 j{\"a}hrlich vom Verband f{\"u}r Patholinguistik e.V. (vpl) durchgef{\"u}hrt. Der vorliegende Tagungsband beinhaltet die vier Hauptvortr{\"a}ge zum Schwerpunktthema, die vier Kurzvortr{\"a}ge aus dem Spektrum Patholinguisitk sowie die Beitr{\"a}ge der Posterpr{\"a}sentationen zu weiteren Themen aus der sprachtherapeutischen Forschung und Praxis.}, language = {de} } @misc{VoigtZimmermannStierLascheitetal.2019, author = {Voigt-Zimmermann, Susanne and Stier, Karl-Heinz and Lascheit, Thomas and Kruse, Stephanie A. and Blickensdorff, Maria and F{\"o}rster, Theresa and Schumacher, Rebecca and Burchert, Frank and Ablinger, Irene and F{\"o}rster, Christine and Wahl, Michael and Schirmacher, Irene and Ostermann, Frank and Welke, Lisa-Marie and Frank, Ulrike and Zakari{\´a}s, Lilla and Salis, Christos and Wartenburger, Isabell and Krug, Ragna and St{\"u}bner, Hanna and Hoffmann, Sophie and Heide, Judith}, title = {Spektrum Patholinguistik Band 11. Schwerpunktthema: Gut gestimmt: Diagnostik und Therapie bei Dysphonie}, number = {11}, editor = {Fritzsche, Tom and Yetim, {\"O}zlem and Otto, Constanze and Adelt, Anne}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-448-7}, issn = {1866-9085}, doi = {10.25932/publishup-41857}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-418574}, pages = {142}, year = {2019}, abstract = {Das 11. Herbsttreffen Patholinguistik mit dem Schwerpunktthema »Gut gestimmt: Diagnostik und Therapie bei Dysphonie« fand am 18.11.2017 in Potsdam statt. Das Herbsttreffen wird seit 2007 j{\"a}hrlich vom Verband f{\"u}r Patholinguistik e.V. (vpl) durchgef{\"u}hrt. Der vorliegende Tagungsband beinhaltet die Hauptvortr{\"a}ge zum Schwerpunktthema sowie Beitr{\"a}ge zu den Kurzvortr{\"a}gen »Spektrum Patholinguistik« und der Posterpr{\"a}sentationen zu weiteren Themen aus der sprachtherapeutischen Forschung und Praxis.}, language = {de} } @article{NeuschaeferRubeOppermannMoelleretal.1999, author = {Neusch{\"a}fer-Rube, Frank and Oppermann, Martin and M{\"o}ller, Ulrike and B{\"o}er, Ulrike and P{\"u}schel, Gerhard Paul}, title = {Agonist-induced phosphorylation by G protein-coupled receptor kinases of the EP4 receptor carboxyl-terminal domain in an EP3/EP4 prostaglandin E(2) receptor hybrid}, issn = {1521-0111}, year = {1999}, abstract = {Prostaglandin E(2) receptors (EP-Rs) belong to the family of heterotrimeric G protein-coupled ectoreceptors with seven transmembrane domains. They can be subdivided into four subtypes according to their ligand-binding and G protein-coupling specificity: EP1 couple to G(q), EP2 and EP4 to G(s), and EP3 to G(i). The EP4-R, in contrast to the EP3beta-R, shows rapid agonist-induced desensitization. The agonist-induced desensitization depends on the presence of the EP4-R carboxyl-terminal domain, which also confers desensitization in a G(i)-coupled rEP3hEP4 carboxyl-terminal domain receptor hybrid (rEP3hEP4-Ct-R). To elucidate the possible mechanism of this desensitization, in vivo phosphorylation stimulated by activators of second messenger kinases, by prostaglandin E(2), or by the EP3-R agonist M\&B28767 was investigated in COS-7 cells expressing FLAG-epitope-tagged rat EP3beta-R (rEP3beta-R), hEP4-R, or rEP3hEP4- Ct-R. Stimulation of protein kinase C with phorbol-12-myristate-13-acetate led to a slight phosphorylation of the FLAG- rEP3beta-R but to a strong phosphorylation of the FLAG-hEP4-R and the FLAG-rEP3hEP4-Ct-R, which was suppressed by the protein kinase A and protein kinase C inhibitor staurosporine. Prostaglandin E(2) stimulated phosphorylation of the FLAG- hEP4-R in its carboxyl-terminal receptor domain. The EP3-R agonist M\&B28767 induced a time- and dose-dependent phosphorylation of the FLAG-rEP3hEP4-Ct-R but not of the FLAG-rEP3beta-R. Agonist-induced phosphorylation of the FLAG- hEP4-R and the FLAG-rEP3hEP4-Ct-R were not inhibited by staurosporine, which implies a role of G protein-coupled receptor kinases (GRKs) in agonist-induced receptor phosphorylation. Overexpression of GRKs in FLAG-rEP3hEP4-Ct-R- expressing COS-7 cells augmented the M\&B28767-induced receptor phosphorylation and receptor sequestration. These findings indicate that phosphorylation of the carboxyl-terminal hEP4-R domain possibly by GRKs but not by second messenger kinases may be involved in rapid agonist-induced desensitization of the hEP4-R and the rEP3hEP4-Ct-R.}, language = {en} } @article{BoeerNeuschaeferRubeMoelleretal.2000, author = {B{\"o}er, Ulrike and Neusch{\"a}fer-Rube, Frank and M{\"o}ller, Ulrike and P{\"u}schel, Gerhard Paul}, title = {Requirement of N-glycosylation of the prostaglandin E2 receptor EP3beta for correct sorting to the plasma membrane but not for correct folding}, year = {2000}, abstract = {Eight heptahelical receptors have been characterized for prostaglandin (PG) D(2), PGE(2), PGF(2alpha), prostacyclin and thromboxane A(2). They share a sequence identity of 40\%. All of them have potential N-glycosylation sites. The current study analysed the role of the two N-glycosylation sites in the rat EP3beta-subtype PGE(2) receptor for protein folding and sorting. The N-glycosylation consensus sequences were eliminated by site-directed mutagenesis and receptors expressed in HEK-293 cells. Both potential N-glycosylation sites were used. Their joint elimination resulted in the synthesis of a receptor protein with full binding competence, biological activity and no reduction of affinity; however, the half-life of the non-glycosylated receptor was slightly reduced. Ligand binding to intact stably transfected cells and confocal laser microscopic immunocytochemistry showed that the glycosylated receptor was correctly inserted into the plasma membrane to a much larger extent than the non-glycosylated receptor, which tended to accumulate in the perinuclear zone of the endoplasmic reticulum. Inhibition of N-glycosylation with tunicamycin resulted in a similar perinuclear distribution of the wild-type receptor. Therefore, glycosylation of the EP3beta receptor seems not to be necessary for correct folding of the receptor protein but for the efficient transport of the receptor protein to the plasma membrane. This contrasts with a previous finding which described a reduction of the affinity for PGE(2) of the EP3alpha receptor by elimination of the distal glycosylation site when the receptor protein was expressed in insect cells.}, language = {en} } @article{GaeckleDomahsKartmannetal.2019, author = {Gaeckle, Maren and Domahs, Frank and Kartmann, Angelika and Tomandl, Bernd and Frank, Ulrike}, title = {Predictors of Penetration-Aspiration in Parkinson's Disease Patients With Dysphagia}, series = {Annals of Otology, Rhinology and Laryngology}, volume = {128}, journal = {Annals of Otology, Rhinology and Laryngology}, number = {8}, publisher = {Sage Publ.}, address = {Thousand Oaks}, issn = {0003-4894}, doi = {10.1177/0003489419841398}, pages = {728 -- 735}, year = {2019}, abstract = {Methods: The data of 89 PD patients with dysphagia who underwent routinely conducted videofluoroscopic studies of swallowing (VFSS) were included in this retrospective study. The occurrence of penetration-aspiration was defined as scores >= 3 on the Penetration-Aspiration Scale (PAS). Four commonly reported signs of dysphagia in PD patients were evaluated as possible predictors. Furthermore, the relationships between the occurrence of penetration-aspiration and liquid bolus volume as well as clinical severity of PD (modified Hoehn and Yahr scale) were examined. Results: Logistic regression showed that a delayed initiation of the pharyngeal swallow (odds ratio [OR] = 7.47, P = .008) and a reduced hyolaryngeal excursion (OR = 5.13, P = .012) were predictors of penetration-aspiration. Moreover, there was a strong, positive correlation between increasing liquid bolus volume and penetration-aspiration (gamma = 0.71, P < .001). No correlation was found between severity of PD and penetration-aspiration (gamma = 0.077, P = .783). Conclusion: Results of the present study allow for a better understanding of penetration-aspiration risk in PD patients. They are useful for treatment planning in order to improve safe oral intake and adequate nutrition.}, language = {en} } @article{FrankFrankZimmermann2015, author = {Frank, Ulrike and Frank, Katrin and Zimmermann, Heinrich}, title = {Effekte einer spezifischen Atemtherapie (Bagging) auf die Atem- und Schluckfunktion bei tracheotomierten Patienten}, series = {Spektrum Patholinguistik (Band 8) - Schwerpunktthema: Besonders behandeln? : Sprachtherapie im Rahmen prim{\"a}rer St{\"o}rungsbilder}, journal = {Spektrum Patholinguistik (Band 8) - Schwerpunktthema: Besonders behandeln? : Sprachtherapie im Rahmen prim{\"a}rer St{\"o}rungsbilder}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-79873}, pages = {235 -- 237}, year = {2015}, language = {de} } @article{FrankFrank2022, author = {Frank, Ulrike and Frank, Katrin}, title = {COVID-19}, series = {Der Nervenarzt : Organ der Deutschen Gesellschaft f{\"u}r Psychiatrie, Psychotherapie und Nervenheilkunde ; Mitteilungsblatt der Deutschen Gesellschaft f{\"u}r Neurologie}, volume = {93}, journal = {Der Nervenarzt : Organ der Deutschen Gesellschaft f{\"u}r Psychiatrie, Psychotherapie und Nervenheilkunde ; Mitteilungsblatt der Deutschen Gesellschaft f{\"u}r Neurologie}, number = {2}, publisher = {Springer}, address = {New York}, issn = {0028-2804}, doi = {10.1007/s00115-021-01162-5}, pages = {167 -- 174}, year = {2022}, abstract = {Eine COVID-19-Erkrankung kann zu schweren Krankheitsverl{\"a}ufen mit multiplen Organbeteiligungen und respiratorischen und neurologischen Funktionseinschr{\"a}nkungen f{\"u}hren. Schluckst{\"o}rungen (Dysphagien) k{\"o}nnen in dieser Patientengruppe durch prim{\"a}re Sch{\"a}digungen des zentralen und peripheren neuronalen Netzwerkes der Schluckfunktion entstehen, aber auch bedingt durch die h{\"a}ufig l{\"a}ngere intensivmedizinische Behandlung und Beatmung. Erste klinische Befunde zeigen persistierende Dysphagien im Rahmen des Post-COVID-Syndroms („Long-COVID"), sodass die Patienten auch l{\"a}ngerfristige Maßnahmen zur Rehabilitation einer sicheren und suffizienten oralen Nahrungsaufnahme ben{\"o}tigen. Daher sollte in die Behandlung von COVID-19-Patienten ein strukturiertes erkrankungsspezifisches Monitoring in Bezug auf Dysphagiesymptome integriert werden, und atemtherapeutische Maßnahmen zur Regulation von Husteneffektivit{\"a}t und Atem-Schluck-Koordination sollten auch bei diesen Patienten essenzieller Bestandteil des Dysphagiemanagements sein. Herausforderungen ergeben sich dabei einerseits durch die erforderlichen Anpassungen etablierter Behandlungsstandards an den Infektionsschutz. Zudem m{\"u}ssen Auswahl und Durchf{\"u}hrungsintensit{\"a}t therapeutischer Maßnahmen an die Kapazit{\"a}ten und die spezifische Pathophysiologie der COVID-19- und Long-COVID-Patienten angepasst werden, um weitere funktionelle Verschlechterungen zu vermindern.}, language = {de} }