@inproceedings{MotalnSchuchhardtStecetal.2014, author = {Motaln, Helena and Schuchhardt, Johannes and Stec, Karol and Breznik, Barbara and Ulrich, Henning and Lah, Tamara T.}, title = {Paradoxical role of mesenchymal stem cells in the glioblastoma microenvironment}, series = {Anticancer research : international journal of cancer research and treatment}, volume = {34}, booktitle = {Anticancer research : international journal of cancer research and treatment}, number = {10}, publisher = {International Institute of Anticancer Research}, address = {Athens}, issn = {0250-7005}, pages = {6071 -- 6072}, year = {2014}, language = {en} } @misc{OlmerEngelsUsmanetal.2018, author = {Olmer, Ruth and Engels, Lena and Usman, Abdulai and Menke, Sandra and Malik, Muhammad Nasir Hayat and Pessler, Frank and G{\"o}hring, Gudrun and Bornhorst, Dorothee and Bolten, Svenja and Abdelilah-Seyfried, Salim and Scheper, Thomas and Kempf, Henning and Zweigerdt, Robert and Martin, Ulrich}, title = {Differentiation of Human Pluripotent Stem Cells into Functional Endothelial Cells in Scalable Suspension Culture}, series = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, number = {5}, issn = {1866-8372}, doi = {10.25932/publishup-42709}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-427095}, pages = {18}, year = {2018}, abstract = {Endothelial cells (ECs) are involved in a variety of cellular responses. As multifunctional components of vascular structures, endothelial (progenitor) cells have been utilized in cellular therapies and are required as an important cellular component of engineered tissue constructs and in vitro disease models. Although primary ECs from different sources are readily isolated and expanded, cell quantity and quality in terms of functionality and karyotype stability is limited. ECs derived from human induced pluripotent stem cells (hiPSCs) represent an alternative and potentially superior cell source, but traditional culture approaches and 2D differentiation protocols hardly allow for production of large cell numbers. Aiming at the production of ECs, we have developed a robust approach for efficient endothelial differentiation of hiPSCs in scalable suspension culture. The established protocol results in relevant numbers of ECs for regenerative approaches and industrial applications that show in vitro proliferation capacity and a high degree of chromosomal stability.}, language = {en} } @article{OlmerEngelsUsmanetal.2018, author = {Olmer, Ruth and Engels, Lena and Usman, Abdulai and Menke, Sandra and Malik, Muhammad Nasir Hayat and Pessler, Frank and Goehring, Gudrun and Bornhorst, Dorothee and Bolten, Svenja and Abdelilah-Seyfried, Salim and Scheper, Thomas and Kempf, Henning and Zweigerdt, Robert and Martin, Ulrich}, title = {Differentiation of Human Pluripotent Stem Cells into Functional Endothelial Cells in Scalable Suspension Culture}, series = {Stem Cell Reports}, volume = {10}, journal = {Stem Cell Reports}, number = {5}, publisher = {Springer}, address = {New York}, issn = {2213-6711}, doi = {10.1016/j.stemcr.2018.03.017}, pages = {16}, year = {2018}, abstract = {Endothelial cells (ECs) are involved in a variety of cellular responses. As multifunctional components of vascular structures, endothelial (progenitor) cells have been utilized in cellular therapies and are required as an important cellular component of engineered tissue constructs and in vitro disease models. Although primary ECs from different sources are readily isolated and expanded, cell quantity and quality in terms of functionality and karyotype stability is limited. ECs derived from human induced pluripotent stem cells (hiPSCs) represent an alternative and potentially superior cell source, but traditional culture approaches and 2D differentiation protocols hardly allow for production of large cell numbers. Aiming at the production of ECs, we have developed a robust approach for efficient endothelial differentiation of hiPSCs in scalable suspension culture. The established protocol results in relevant numbers of ECs for regenerative approaches and industrial applications that show in vitro proliferation capacity and a high degree of chromosomal stability.}, language = {en} } @article{WittigMirandaHoelzeretal.2022, author = {Wittig, Alice and Miranda, Fabio Malcher and H{\"o}lzer, Martin and Altenburg, Tom and Bartoszewicz, Jakub Maciej and Beyvers, Sebastian and Dieckmann, Marius Alfred and Genske, Ulrich and Giese, Sven Hans-Joachim and Nowicka, Melania and Richard, Hugues and Schiebenhoefer, Henning and Schmachtenberg, Anna-Juliane and Sieben, Paul and Tang, Ming and Tembrockhaus, Julius and Renard, Bernhard Y. and Fuchs, Stephan}, title = {CovRadar}, series = {Bioinformatics}, volume = {38}, journal = {Bioinformatics}, number = {17}, publisher = {Oxford Univ. Press}, address = {Oxford}, issn = {1367-4803}, doi = {10.1093/bioinformatics/btac411}, pages = {4223 -- 4225}, year = {2022}, abstract = {The ongoing pandemic caused by SARS-CoV-2 emphasizes the importance of genomic surveillance to understand the evolution of the virus, to monitor the viral population, and plan epidemiological responses. Detailed analysis, easy visualization and intuitive filtering of the latest viral sequences are powerful for this purpose. We present CovRadar, a tool for genomic surveillance of the SARS-CoV-2 Spike protein. CovRadar consists of an analytical pipeline and a web application that enable the analysis and visualization of hundreds of thousand sequences. First, CovRadar extracts the regions of interest using local alignment, then builds a multiple sequence alignment, infers variants and consensus and finally presents the results in an interactive app, making accessing and reporting simple, flexible and fast.}, language = {en} } @misc{MarkschiesPaesslerGroteetal.2021, author = {Markschies, Christoph and P{\"a}ßler, Ulrich and Grote, Mathias and Greenwood MacKinney, Anne and Kusber, Wolf-Henning and Jahn, Regine and Damaschun, Ferdinand and B{\"o}hme, Katrin}, title = {HiN : Alexander von Humboldt im Netz = Christian Gottfried Ehrenberg}, volume = {XXII}, number = {42}, editor = {Ette, Ottmar and Knobloch, Eberhard and P{\"a}ßler, Ulrich}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {2568-3543}, doi = {10.25932/publishup-50141}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-501413}, pages = {169}, year = {2021}, abstract = {-Christoph Markschies: Geleitwort -Ulrich P{\"a}ßler: Christian Gottfried Ehrenberg: Lebensbilder eines Naturforschers -Mathias Grote: „Aus dem Kleinen bauen sich die Welten" - Christian Gottfried Ehrenbergs {\"o}kologische Mikrobiologie avant la lettre -Anne Greenwood MacKinney: Die Inszenierung naturforschender Gelehrsamkeit beim Sammeln: Christian Gottfried Ehrenbergs und Wilhelm Hemprichs nordafrikanische Forschungsreise (1820 - 1825) -Ulrich P{\"a}ßler: Reisen im Nahen Osten. Zeichnungen -Ulrich P{\"a}ßler: Christian Gottfried Ehrenberg und die Biogeographie: Die russisch-sibirische Reise mit Alexander von Humboldt (1829) -Ulrich P{\"a}ßler: Russisch-Sibirische Reise. Zeichnungen -Wolf-Henning Kusber, Regine Jahn: Christian Gottfried Ehrenbergs Zeichnungen: Eine fr{\"u}he wissenschaftliche Dokumentation mikroskopischer Organismen -Ferdinand Damaschun: Christian Gottfried Ehrenberg und die Entwicklung der Mikroskop-Technik im 19. Jahrhundert -Ulrich P{\"a}ßler: Die Reise ins Kleinste der Natur. Zeichnungen -Katrin B{\"o}hme: Das große Ganze: Christian Gottfried Ehrenberg und die Gesellschaft Naturforschender Freunde zu Berlin}, language = {de} }