@article{HoldtMuellerKellingetal.2006,
  author    = {Holdt, Hans-J{\"u}rgen and M{\"u}ller, Holger and Kelling, Alexandra and Drexler, Hans-Joachim and M{\"u}ller, Thomas and Schwarze, Thomas and Schilde, Uwe and Starke, Ines},
  title     = {Mercury(II) chloride and iodide complexes of dithia- and tetrathiacrown ethers},
  issn      = {0044-2313},
  doi       = {10.1002/zaac.200500281},
  year      = {2006},
  abstract  = {The complexes [(HgCl2)(2)((ch)(2)30S(4)O(6))] (1), [HgCl,(mn21S(2)O(5))] (2), [HgCl2(ch18S(2)O(4))] (3) and [HgI(meb12S(2)O(2))](2)[Hg2I6] (4) have been synthesized, characterized and their crystal structures were determined. In [(HgCl2)(2)((ch)(2)3OS(4)O(6))] two HgCl2 units are discretely bonded within the ligand cavity of the 30-membered dichinoxaline-tetrathia-30-crown-10 ((ch)(2)30S(4)O(6)) forming a binuclear complex. HgCl2 forms I : I "in-cavity" complexes with the 21-membered maleonitrile-dithia-21-crown-7(mn21S(2)O(5)) ligand and the 18-membered chinoxaline- dithia-18-crown-6 (ch18S(2)O(4)) ligand, respectively. The 12-membered 4-methyl-benzo-dithia-12-crown-4 (meb12S(2)O(2)) ligand gave with two equivalents HgI2 the compound [HgI(meb12S(2)O(2))](2)[Hg2I6]. In the cation [HgI(meb12S(2)O(2))](+) meb12S(2)O(2) forms with the cation HgI+ a half-sandwich complex},
  language  = {en}
}
@misc{MaierWolfKeiligetal.2018,
  author    = {Maier, Philipp and Wolf, J{\"u}rgen and Keilig, Thomas and Krabbe, Alfred and Duffard, Rene and Ortiz, Jose-Luis and Klinkner, Sabine and Lengowski, Michael and M{\"u}ller, Thomas and Lockowandt, Christian and Krockstedt, Christian and Kappelmann, Norbert and Stelzer, Beate and Werner, Klaus and Geier, Stephan and Kalkuhl, Christoph and Rauch, Thomas and Schanz, Thomas and Barnstedt, J{\"u}rgen and Conti, Lauro and Hanke, Lars},
  title     = {Towards a European Stratospheric Balloon Observatory},
  series = {Ground-based and Airborne Telescopes VII},
  volume    = {10700},
  journal   = {Ground-based and Airborne Telescopes VII},
  publisher = {SPIE-INT Soc Optical Engineering},
  address   = {Bellingham},
  isbn      = {978-1-5106-1954-8},
  issn      = {0277-786X},
  doi       = {10.1117/12.2319248},
  pages     = {12},
  year      = {2018},
  abstract  = {This paper presents the concept of a community-accessible stratospheric balloon-based observatory that is currently under preparation by a consortium of European research institutes and industry. We present the technical motivation, science case, instrumentation, and a two-stage image stabilization approach of the 0.5-m UV/visible platform. In addition, we briefly describe the novel mid-sized stabilized balloon gondola under design to carry telescopes in the 0.5 to 0.6 m range as well as the currently considered flight option for this platform. Secondly, we outline the scientific and technical motivation for a large balloon-based FIR telescope and the ESBO DS approach towards such an infrastructure.},
  language  = {en}
}
@article{ReadKegelKluteetal.2013,
  author    = {Read, Betsy A. and Kegel, Jessica and Klute, Mary J. and Kuo, Alan and Lefebvre, Stephane C. and Maumus, Florian and Mayer, Christoph and Miller, John and Monier, Adam and Salamov, Asaf and Young, Jeremy and Aguilar, Maria and Claverie, Jean-Michel and Frickenhaus, Stephan and Gonzalez, Karina and Herman, Emily K. and Lin, Yao-Cheng and Napier, Johnathan and Ogata, Hiroyuki and Sarno, Analissa F. and Shmutz, Jeremy and Schroeder, Declan and de Vargas, Colomban and Verret, Frederic and von Dassow, Peter and Valentin, Klaus and Van de Peer, Yves and Wheeler, Glen and Dacks, Joel B. and Delwiche, Charles F. and Dyhrman, Sonya T. and Gl{\"o}ckner, Gernot and John, Uwe and Richards, Thomas and Worden, Alexandra Z. and Zhang, Xiaoyu and Grigoriev, Igor V. and Allen, Andrew E. and Bidle, Kay and Borodovsky, M. and Bowler, C. and Brownlee, Colin and Cock, J. Mark and Elias, Marek and Gladyshev, Vadim N. and Groth, Marco and Guda, Chittibabu and Hadaegh, Ahmad and Iglesias-Rodriguez, Maria Debora and Jenkins, J. and Jones, Bethan M. and Lawson, Tracy and Leese, Florian and Lindquist, Erika and Lobanov, Alexei and Lomsadze, Alexandre and Malik, Shehre-Banoo and Marsh, Mary E. and Mackinder, Luke and Mock, Thomas and M{\"u}ller-R{\"o}ber, Bernd and Pagarete, Antonio and Parker, Micaela and Probert, Ian and Quesneville, Hadi and Raines, Christine and Rensing, Stefan A. and Riano-Pachon, Diego Mauricio and Richier, Sophie and Rokitta, Sebastian and Shiraiwa, Yoshihiro and Soanes, Darren M. and van der Giezen, Mark and Wahlund, Thomas M. and Williams, Bryony and Wilson, Willie and Wolfe, Gordon and Wurch, Louie L.},
  title     = {Pan genome of the phytoplankton Emiliania underpins its global distribution},
  series = {Nature : the international weekly journal of science},
  volume    = {499},
  journal   = {Nature : the international weekly journal of science},
  number    = {7457},
  publisher = {Nature Publ. Group},
  address   = {London},
  organization    = {Emiliania Huxleyi Annotation},
  issn      = {0028-0836},
  doi       = {10.1038/nature12221},
  pages     = {209 -- 213},
  year      = {2013},
  abstract  = {Coccolithophores have influenced the global climate for over 200 million years(1). These marine phytoplankton can account for 20 per cent of total carbon fixation in some systems(2). They form blooms that can occupy hundreds of thousands of square kilometres and are distinguished by their elegantly sculpted calcium carbonate exoskeletons (coccoliths), rendering them visible from space(3). Although coccolithophores export carbon in the form of organic matter and calcite to the sea floor, they also release CO2 in the calcification process. Hence, they have a complex influence on the carbon cycle, driving either CO2 production or uptake, sequestration and export to the deep ocean(4). Here we report the first haptophyte reference genome, from the coccolithophore Emiliania huxleyi strain CCMP1516, and sequences from 13 additional isolates. Our analyses reveal a pan genome (core genes plus genes distributed variably between strains) probably supported by an atypical complement of repetitive sequence in the genome. Comparisons across strains demonstrate that E. huxleyi, which has long been considered a single species, harbours extensive genome variability reflected in different metabolic repertoires. Genome variability within this species complex seems to underpin its capacity both to thrive in habitats ranging from the equator to the subarctic and to form large-scale episodic blooms under a wide variety of environmental conditions.},
  language  = {en}
}
@article{AartsAndersonAndersonetal.2015,
  author    = {Aarts, Alexander A. and Anderson, Joanna E. and Anderson, Christopher J. and Attridge, Peter R. and Attwood, Angela and Axt, Jordan and Babel, Molly and Bahnik, Stepan and Baranski, Erica and Barnett-Cowan, Michael and Bartmess, Elizabeth and Beer, Jennifer and Bell, Raoul and Bentley, Heather and Beyan, Leah and Binion, Grace and Borsboom, Denny and Bosch, Annick and Bosco, Frank A. and Bowman, Sara D. and Brandt, Mark J. and Braswell, Erin and Brohmer, Hilmar and Brown, Benjamin T. and Brown, Kristina and Bruening, Jovita and Calhoun-Sauls, Ann and Callahan, Shannon P. and Chagnon, Elizabeth and Chandler, Jesse and Chartier, Christopher R. and Cheung, Felix and Christopherson, Cody D. and Cillessen, Linda and Clay, Russ and Cleary, Hayley and Cloud, Mark D. and Cohn, Michael and Cohoon, Johanna and Columbus, Simon and Cordes, Andreas and Costantini, Giulio and Alvarez, Leslie D. Cramblet and Cremata, Ed and Crusius, Jan and DeCoster, Jamie and DeGaetano, Michelle A. and Della Penna, Nicolas and den Bezemer, Bobby and Deserno, Marie K. and Devitt, Olivia and Dewitte, Laura and Dobolyi, David G. and Dodson, Geneva T. and Donnellan, M. Brent and Donohue, Ryan and Dore, Rebecca A. and Dorrough, Angela and Dreber, Anna and Dugas, Michelle and Dunn, Elizabeth W. and Easey, Kayleigh and Eboigbe, Sylvia and Eggleston, Casey and Embley, Jo and Epskamp, Sacha and Errington, Timothy M. and Estel, Vivien and Farach, Frank J. and Feather, Jenelle and Fedor, Anna and Fernandez-Castilla, Belen and Fiedler, Susann and Field, James G. and Fitneva, Stanka A. and Flagan, Taru and Forest, Amanda L. and Forsell, Eskil and Foster, Joshua D. and Frank, Michael C. and Frazier, Rebecca S. and Fuchs, Heather and Gable, Philip and Galak, Jeff and Galliani, Elisa Maria and Gampa, Anup and Garcia, Sara and Gazarian, Douglas and Gilbert, Elizabeth and Giner-Sorolla, Roger and Gl{\"o}ckner, Andreas and G{\"o}llner, Lars and Goh, Jin X. and Goldberg, Rebecca and Goodbourn, Patrick T. and Gordon-McKeon, Shauna and Gorges, Bryan and Gorges, Jessie and Goss, Justin and Graham, Jesse and Grange, James A. and Gray, Jeremy and Hartgerink, Chris and Hartshorne, Joshua and Hasselman, Fred and Hayes, Timothy and Heikensten, Emma and Henninger, Felix and Hodsoll, John and Holubar, Taylor and Hoogendoorn, Gea and Humphries, Denise J. and Hung, Cathy O. -Y. and Immelman, Nathali and Irsik, Vanessa C. and Jahn, Georg and Jaekel, Frank and Jekel, Marc and Johannesson, Magnus and Johnson, Larissa G. and Johnson, David J. and Johnson, Kate M. and Johnston, William J. and Jonas, Kai and Joy-Gaba, Jennifer A. and Kappes, Heather Barry and Kelso, Kim and Kidwell, Mallory C. and Kim, Seung Kyung and Kirkhart, Matthew and Kleinberg, Bennett and Knezevic, Goran and Kolorz, Franziska Maria and Kossakowski, Jolanda J. and Krause, Robert Wilhelm and Krijnen, Job and Kuhlmann, Tim and Kunkels, Yoram K. and Kyc, Megan M. and Lai, Calvin K. and Laique, Aamir and Lakens, Daniel and Lane, Kristin A. and Lassetter, Bethany and Lazarevic, Ljiljana B. and LeBel, Etienne P. and Lee, Key Jung and Lee, Minha and Lemm, Kristi and Levitan, Carmel A. and Lewis, Melissa and Lin, Lin and Lin, Stephanie and Lippold, Matthias and Loureiro, Darren and Luteijn, Ilse and Mackinnon, Sean and Mainard, Heather N. and Marigold, Denise C. and Martin, Daniel P. and Martinez, Tylar and Masicampo, E. J. and Matacotta, Josh and Mathur, Maya and May, Michael and Mechin, Nicole and Mehta, Pranjal and Meixner, Johannes and Melinger, Alissa and Miller, Jeremy K. and Miller, Mallorie and Moore, Katherine and M{\"o}schl, Marcus and Motyl, Matt and M{\"u}ller, Stephanie M. and Munafo, Marcus and Neijenhuijs, Koen I. and Nervi, Taylor and Nicolas, Gandalf and Nilsonne, Gustav and Nosek, Brian A. and Nuijten, Michele B. and Olsson, Catherine and Osborne, Colleen and Ostkamp, Lutz and Pavel, Misha and Penton-Voak, Ian S. and Perna, Olivia and Pernet, Cyril and Perugini, Marco and Pipitone, R. Nathan and Pitts, Michael and Plessow, Franziska and Prenoveau, Jason M. and Rahal, Rima-Maria and Ratliff, Kate A. and Reinhard, David and Renkewitz, Frank and Ricker, Ashley A. and Rigney, Anastasia and Rivers, Andrew M. and Roebke, Mark and Rutchick, Abraham M. and Ryan, Robert S. and Sahin, Onur and Saide, Anondah and Sandstrom, Gillian M. and Santos, David and Saxe, Rebecca and Schlegelmilch, Rene and Schmidt, Kathleen and Scholz, Sabine and Seibel, Larissa and Selterman, Dylan Faulkner and Shaki, Samuel and Simpson, William B. and Sinclair, H. Colleen and Skorinko, Jeanine L. M. and Slowik, Agnieszka and Snyder, Joel S. and Soderberg, Courtney and Sonnleitner, Carina and Spencer, Nick and Spies, Jeffrey R. and Steegen, Sara and Stieger, Stefan and Strohminger, Nina and Sullivan, Gavin B. and Talhelm, Thomas and Tapia, Megan and te Dorsthorst, Anniek and Thomae, Manuela and Thomas, Sarah L. and Tio, Pia and Traets, Frits and Tsang, Steve and Tuerlinckx, Francis and Turchan, Paul and Valasek, Milan and Van Aert, Robbie and van Assen, Marcel and van Bork, Riet and van de Ven, Mathijs and van den Bergh, Don and van der Hulst, Marije and van Dooren, Roel and van Doorn, Johnny and van Renswoude, Daan R. and van Rijn, Hedderik and Vanpaemel, Wolf and Echeverria, Alejandro Vasquez and Vazquez, Melissa and Velez, Natalia and Vermue, Marieke and Verschoor, Mark and Vianello, Michelangelo and Voracek, Martin and Vuu, Gina and Wagenmakers, Eric-Jan and Weerdmeester, Joanneke and Welsh, Ashlee and Westgate, Erin C. and Wissink, Joeri and Wood, Michael and Woods, Andy and Wright, Emily and Wu, Sining and Zeelenberg, Marcel and Zuni, Kellylynn},
  title     = {Estimating the reproducibility of psychological science},
  series = {Science},
  volume    = {349},
  journal   = {Science},
  number    = {6251},
  publisher = {American Assoc. for the Advancement of Science},
  address   = {Washington},
  organization    = {Open Sci Collaboration},
  issn      = {1095-9203},
  doi       = {10.1126/science.aac4716},
  pages     = {8},
  year      = {2015},
  abstract  = {Reproducibility is a defining feature of science, but the extent to which it characterizes current research is unknown. We conducted replications of 100 experimental and correlational studies published in three psychology journals using high-powered designs and original materials when available. Replication effects were half the magnitude of original effects, representing a substantial decline. Ninety-seven percent of original studies had statistically significant results. Thirty-six percent of replications had statistically significant results; 47\% of original effect sizes were in the 95\% confidence interval of the replication effect size; 39\% of effects were subjectively rated to have replicated the original result; and if no bias in original results is assumed, combining original and replication results left 68\% with statistically significant effects. Correlational tests suggest that replication success was better predicted by the strength of original evidence than by characteristics of the original and replication teams.},
  language  = {en}
}
@article{AstSchwarzeMuelleretal.2013,
  author    = {Ast, Sandra and Schwarze, Thomas and M{\"u}ller, Holger and Sukhanov, Aleksey and Michaelis, Stefanie and Wegener, Joachim and Wolfbeis, Otto S. and K{\"o}rzd{\"o}rfer, Thomas and D{\"u}rkop, Axel and Holdt, Hans-J{\"u}rgen},
  title     = {A highly K+-Selective Phenylaza-[18]crown-6-Lariat-Ether-Based Fluoroionophore and its application in the sensing of K+ Ions with an optical sensor film and in cells},
  series = {Chemistry - a European journal},
  volume    = {19},
  journal   = {Chemistry - a European journal},
  number    = {44},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {0947-6539},
  doi       = {10.1002/chem.201302350},
  pages     = {14911 -- 14917},
  year      = {2013},
  abstract  = {Herein, we report the synthesis of two phenylaza-[18]crown-6 lariat ethers with a coumarin fluorophore (1 and 2) and we reveal that compound 1 is an excellent probe for K+ ions under simulated physiological conditions. The presence of a 2-methoxyethoxy lariat group at the ortho position of the anilino moiety is crucial to the substantially increased stability of compounds 1 and 2 over their lariat-free phenylaza-[18] crown-6 ether analogues. Probe 1 shows a high K+/Na+ selectivity and a 2.5-fold fluorescence enhancement was observed in the presence of 100 mm K+ ions. A fluorescent membrane sensor, which was prepared by incorporating probe 1 into a hydrogel, showed a fully reversible response, a response time of 150 s, and a signal change of 7.8\% per 1 mm K+ within the range 1-10 mm K+. The membrane was easily fabricated (only a single sensing layer on a solid polyester support), yet no leaching was observed. Moreover, compound 1 rapidly permeated into cells, was cytocompatible, and was suitable for the fluorescent imaging of K+ ions on both the extracellular and intracellular levels.},
  language  = {en}
}
@article{SchwarzeSperlichMuelleretal.2021,
  author    = {Schwarze, Thomas and Sperlich, Eric and M{\"u}ller, Thomas and Kelling, Alexandra and Holdt, Hans-J{\"u}rgen},
  title     = {Synthesis efforts of acyclic bis(monoalkylamino)maleonitriles and macrocyclic bis(dialkylamino)maleonitriles as fluorescent probes for cations and a new colorimetric copper(II) chemodosimeter},
  series = {Helvetica chimica acta},
  volume    = {104},
  journal   = {Helvetica chimica acta},
  number    = {6},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1522-2675},
  doi       = {10.1002/hlca.202100028},
  pages     = {e2100028},
  year      = {2021},
  abstract  = {In this article, we report on the synthesis of acyclic bis(monoalkylamino)maleonitriles and on the intended synthesis of macrocyclic bis(dialkylamino)maleonitriles to get fluorescent probes for cations. During our efforts to synthesize macrocyclic bis(dialkylamino)maleonitriles, we were only able to isolate macrocyclic bis(dialkylamino)-fumaronitriles. The synthesis of macrocyclic bis(dialkylamino)maleonitriles is challenging, due to the fact that bis-(dialkylamino)fumaronitriles are thermodynamically more stable than the corresponding bis(dialkylamino)-maleonitriles. Further, it turned out that the acyclic bis(monoalkylamino)maleonitriles and macrocyclic bis-(dialkylamino)fumaronitriles are no suitable tools to detect cations by a strong fluorescence enhancement. Further, only the bis(monoalkylamino)maleonitriles, which are bearing a 2-pyridyl unit as an additional complexing unit, are able to selectively recognize copper(II) by a color change from yellow to red.},
  language  = {en}
}
@article{ReimoldFischerMuelleretal.2015,
  author    = {Reimold, Wolf Uwe and Fischer, Luise and M{\"u}ller, Jan and Kenkmann, Thomas and Schmitt, Ralf-Thomas and Altenberger, Uwe and Kowitz, Astrid},
  title     = {Impact-generated pseudotachylitic breccia in drill core BH-5 Hattberg, Siljan impact structure, Sweden},
  series = {GFF},
  volume    = {137},
  journal   = {GFF},
  number    = {2},
  publisher = {Routledge, Taylor \& Francis Group},
  address   = {Abingdon},
  issn      = {1103-5897},
  doi       = {10.1080/11035897.2015.1015264},
  pages     = {141 -- 162},
  year      = {2015},
  abstract  = {Pseudotachylitic breccia (PTB) in the form of cm-wide melt breccia veinlets locally occurs on the exposed central uplift of the 380Ma Siljan impact structure. The host rock to the PTBs is the so-called Jarna granite of quartz monzonitic to syenodioritic composition. The nearly 603m long BH-5 drill core from Hattberg, near the centre of the Siljan central uplift, contains numerous veins and pods of PTB. In particular, two major zones of 60m combined width contain extensive PTB network breccias (30\% actual melt breccia component), with individual melt breccia occurrences up to >1m in length. Core logging and petrographic and geochemical analysis of the core have been performed, and the data are interpreted to suggest the following. (1) The impact event caused low to moderate (at essentially <20GPa) shock deformation in the host rock and in clasts of this lithology within the PTB. (2) Macroscopic deformation of the basement mainly comprises fracturing, with only localised cataclasis. (3) No evidence for shock melting (i.e. compression/decompression melting early in the cratering process) could be observed. (4) Optical and scanning electron microscopy showed that dark PTB contains a definite melt component. (5) Shearing has significantly affected this part of the central uplift, but its effects are limited to very short displacements and likely did not result in extensive melting. (6) A frictional heating component upon melt generation can, however, not be excluded, as many PTB samples contain clasts of a mafic (gabbroic) component, although only in one place along the entire core, a 1.2cm-wide section through such material in direct contact to host rock was observed. Consequently, we suggest that, upon uplift in the central part of the impact structure, considerable melt volumes were generated locally, especially in areas that had been affected by extensive cataclasis and where grain size comminution favoured melt formation. Rapid decompression related to central uplift formation is the preferred process for the generation of the PTB melt breccias.},
  language  = {en}
}
@article{SchatzFreulingAueretal.2014,
  author    = {Schatz, Juliane and Freuling, Conrad Martin and Auer, Ernst and Goharriz, Hooman and Harbusch, Christine and Johnson, Nicholas and Kaipf, Ingrid and Mettenleiter, Thomas Christoph and Muehldorder, Kristin and Muehle, Ralf-Udo and Ohlendorf, Bernd and Pott-D{\"o}rfer, B{\"a}rbel and Prueger, Julia and Ali, Hanan Sheikh and Stiefel, Dagmar and Teubner, Jens and Ulrich, Rainer G{\"u}nter and Wibbelt, Gudrun and M{\"u}ller, Thomas},
  title     = {Enhanced passive bat rabies surveillance in indigenous bat species from Germany - A retrospective study},
  series = {PLoS neglected tropical diseases},
  volume    = {8},
  journal   = {PLoS neglected tropical diseases},
  number    = {5},
  publisher = {PLoS},
  address   = {San Fransisco},
  issn      = {1935-2735},
  doi       = {10.1371/journal.pntd.0002835},
  pages     = {9},
  year      = {2014},
  abstract  = {In Germany, rabies in bats is a notifiable zoonotic disease, which is caused by European bat lyssaviruses type 1 and 2 (EBLV-1 and 2), and the recently discovered new lyssavirus species Bokeloh bat lyssavirus (BBLV). As the understanding of bat rabies in insectivorous bat species is limited, in addition to routine bat rabies diagnosis, an enhanced passive surveillance study, i.e. the retrospective investigation of dead bats that had not been tested for rabies, was initiated in 1998 to study the distribution, abundance and epidemiology of lyssavirus infections in bats from Germany. A total number of 5478 individuals representing 21 bat species within two families were included in this study. The Noctule bat (Nyctalus noctula) and the Common pipistrelle (Pipistrellus pipistrellus) represented the most specimens submitted. Of all investigated bats, 1.17\% tested positive for lyssaviruses using the fluorescent antibody test (FAT). The vast majority of positive cases was identified as EBLV-1, predominately associated with the Serotine bat (Eptesicus serotinus). However, rabies cases in other species, i.e. Nathusius' pipistrelle bat (Pipistrellus nathusii), P. pipistrellus and Brown long-eared bat (Plecotus auritus) were also characterized as EBLV-1. In contrast, EBLV-2 was isolated from three Daubenton's bats (Myotis daubentonii). These three cases contribute significantly to the understanding of EBLV-2 infections in Germany as only one case had been reported prior to this study. This enhanced passive surveillance indicated that besides known reservoir species, further bat species are affected by lyssavirus infections. Given the increasing diversity of lyssaviruses and bats as reservoir host species worldwide, lyssavirus positive specimens, i.e. both bat and virus need to be confirmed by molecular techniques.},
  language  = {en}
}
@article{LaquaiSchauppGriescheetal.2022,
  author    = {Laquai, Ren{\´e} and Schaupp, Thomas and Griesche, Axel and M{\"u}ller, Bernd R. and Kupsch, Andreas and Hannemann, Andreas and Kannengiesser, Thomas and Bruno, Giovanni},
  title     = {Quantitative analysis of hydrogen-assisted microcracking in duplex stainless steel through X-ray refraction 3D imaging},
  series = {Advanced engineering materials},
  volume    = {24},
  journal   = {Advanced engineering materials},
  number    = {6},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1527-2648},
  doi       = {10.1002/adem.202101287},
  pages     = {10},
  year      = {2022},
  abstract  = {While the problem of the identification of mechanisms of hydrogen-assisted damage has and is being thoroughly studied, the quantitative analysis of such damage still lacks suitable tools. In fact, while, for instance, electron microscopy yields excellent characterization, the quantitative analysis of damage requires at the same time large field-of-views and high spatial resolution. Synchrotron X-ray refraction techniques do possess both features. Herein, it is shown how synchrotron X-ray refraction computed tomography (SXRCT) can quantify damage induced by hydrogen embrittlement in a lean duplex steel, yielding results that overperform even those achievable by synchrotron X-ray absorption computed tomography. As already reported in the literature, but this time using a nondestructive technique, it is shown that the hydrogen charge does not penetrate to the center of tensile specimens. By the comparison between virgin and hydrogen-charged specimens, it is deduced that cracks in the specimen bulk are due to the rolling process rather than hydrogen-assisted. It is shown that (micro)cracks propagate from the surface of tensile specimens to the interior with increasing applied strain, and it is deduced that a significant crack propagation can only be observed short before rupture.},
  language  = {en}
}
@article{DiekmannAndresBeckeretal.2019,
  author    = {Diekmann, Martin and Andres, Christian and Becker, Thomas and Bennie, Jonathan and Blueml, Volker and Bullock, James M. and Culmsee, Heike and Fanigliulo, Miriam and Hahn, Annett and Heinken, Thilo and Leuschner, Christoph and Luka, Stefanie and Meissner, Justus and M{\"u}ller, Josef and Newton, Adrian and Peppler-Lisbach, Cord and Rosenthal, Gert and van den Berg, Leon J. L. and Vergeer, Philippine and Wesche, Karsten},
  title     = {Patterns of long-term vegetation change vary between different types of semi-natural grasslands in Western and Central Europe},
  series = {Journal of vegetation science},
  volume    = {30},
  journal   = {Journal of vegetation science},
  number    = {2},
  publisher = {Wiley},
  address   = {Hoboken},
  issn      = {1100-9233},
  doi       = {10.1111/jvs.12727},
  pages     = {187 -- 202},
  year      = {2019},
  abstract  = {Questions Has plant species richness in semi-natural grasslands changed over recent decades? Do the temporal trends of habitat specialists differ from those of habitat generalists? Has there been a homogenization of the grassland vegetation? Location Different regions in Germany and the UK. Methods We conducted a formal meta-analysis of re-survey vegetation studies of semi-natural grasslands. In total, 23 data sets were compiled, spanning up to 75 years between the surveys, including 13 data sets from wet grasslands, six from dry grasslands and four from other grassland types. Edaphic conditions were assessed using mean Ellenberg indicator values for soil moisture, nitrogen and pH. Changes in species richness and environmental variables were evaluated using response ratios. Results In most wet grasslands, total species richness declined over time, while habitat specialists almost completely vanished. The number of species losses increased with increasing time between the surveys and were associated with a strong decrease in soil moisture and higher soil nutrient contents. Wet grasslands in nature reserves showed no such changes or even opposite trends. In dry grasslands and other grassland types, total species richness did not consistently change, but the number or proportions of habitat specialists declined. There were also considerable changes in species composition, especially in wet grasslands that often have been converted into intensively managed, highly productive meadows or pastures. We did not find a general homogenization of the vegetation in any of the grassland types. Conclusions The results document the widespread deterioration of semi-natural grasslands, especially of those types that can easily be transformed to high production grasslands. The main causes for the loss of grassland specialists are changed management in combination with increased fertilization and nitrogen deposition. Dry grasslands are most resistant to change, but also show a long-term trend towards an increase in more mesotrophic species.},
  language  = {en}
}
@inproceedings{CurzonKalasSchubertetal.2015,
  author    = {Curzon, Paul and Kalas, Ivan and Schubert, Sigrid and Schaper, Niclas and Barnes, Jan and Kennewell, Steve and Br{\"o}ker, Kathrin and Kastens, Uwe and Magenheim, Johannes and Dagiene, Valentina and Stupuriene, Gabriele and Ellis, Jason Brent and Abreu-Ellis, Carla Reis and Grillenberger, Andreas and Romeike, Ralf and Haugsbakken, Halvdan and Jones, Anthony and Lewin, Cathy and McNicol, Sarah and Nelles, Wolfgang and Neugebauer, Jonas and Ohrndorf, Laura and Schaper, Niclas and Schubert, Sigrid and Opel, Simone and Kramer, Matthias and Trommen, Michael and Pottb{\"a}cker, Florian and Ilaghef, Youssef and Passig, David and Tzuriel, David and Kedmi, Ganit Eshel and Saito, Toshinori and Webb, Mary and Weigend, Michael and Bottino, Rosa and Chioccariello, Augusto and Christensen, Rhonda and Knezek, Gerald and Gioko, Anthony Maina and Angondi, Enos Kiforo and Waga, Rosemary and Ohrndorf, Laura and Or-Bach, Rachel and Preston, Christina and Younie, Sarah and Przybylla, Mareen and Romeike, Ralf and Reynolds, Nicholas and Swainston, Andrew and Bendrups, Faye and Sysło, Maciej M. and Kwiatkowska, Anna Beata and Zieris, Holger and Gerstberger, Herbert and M{\"u}ller, Wolfgang and B{\"u}chner, Steffen and Opel, Simone and Schiller, Thomas and Wegner, Christian and Zender, Raphael and Lucke, Ulrike and Diethelm, Ira and Syrbe, J{\"o}rn and Lai, Kwok-Wing and Davis, Niki and Eickelmann, Birgit and Erstad, Ola and Fisser, Petra and Gibson, David and Khaddage, Ferial and Knezek, Gerald and Micheuz, Peter and Kloos, Carlos Delgado},
  title     = {KEYCIT 2014},
  editor    = {Brinda, Torsten and Reynolds, Nicholas and Romeike, Ralf and Schwill, Andreas},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-292-6},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-70325},
  pages     = {438},
  year      = {2015},
  abstract  = {In our rapidly changing world it is increasingly important not only to be an expert in a chosen field of study but also to be able to respond to developments, master new approaches to solving problems, and fulfil changing requirements in the modern world and in the job market. In response to these needs key competencies in understanding, developing and using new digital technologies are being brought into focus in school and university programmes. The IFIP TC3 conference "KEYCIT - Key Competences in Informatics and ICT (KEYCIT 2014)" was held at the University of Potsdam in Germany from July 1st to 4th, 2014 and addressed the combination of key competencies, Informatics and ICT in detail. The conference was organized into strands focusing on secondary education, university education and teacher education (organized by IFIP WGs 3.1 and 3.3) and provided a forum to present and to discuss research, case studies, positions, and national perspectives in this field.},
  language  = {en}
}
@article{LiebeDordevicKaufmannetal.2022,
  author    = {Liebe, Thomas and Dordevic, Milos and Kaufmann, J{\"o}rn and Avetisyan, Araks and Skalej, Martin and M{\"u}ller, Notger Germar},
  title     = {Investigation of the functional pathogenesis of mild cognitive impairment by localisation-based locus coeruleus resting-state fMRI},
  series = {Human Brain Mapping},
  volume    = {43},
  journal   = {Human Brain Mapping},
  edition   = {18},
  publisher = {Wiley},
  address   = {New York, NY, USA},
  issn      = {1097-0193},
  doi       = {10.1002/hbm.26039},
  pages     = {5630 -- 5642},
  year      = {2022},
  abstract  = {Dementia as one of the most prevalent diseases urges for a better understanding of the central mechanisms responsible for clinical symptoms, and necessitates improvement of actual diagnostic capabilities. The brainstem nucleus locus coeruleus (LC) is a promising target for early diagnosis because of its early structural alterations and its relationship to the functional disturbances in the patients. In this study, we applied our improved method of localisation-based LC resting-state fMRI to investigate the differences in central sensory signal processing when comparing functional connectivity (fc) of a patient group with mild cognitive impairment (MCI, n = 28) and an age-matched healthy control group (n = 29). MCI and control participants could be differentiated in their Mini-Mental-State-Examination (MMSE) scores (p < .001) and LC intensity ratio (p = .010). In the fMRI, LC fc to anterior cingulate cortex (FDR p < .001) and left anterior insula (FDR p = .012) was elevated, and LC fc to right temporoparietal junction (rTPJ, FDR p = .012) and posterior cingulate cortex (PCC, FDR p = .021) was decreased in the patient group. Importantly, LC to rTPJ connectivity was also positively correlated to MMSE scores in MCI patients (p = .017). Furthermore, we found a hyperactivation of the left-insula salience network in the MCI patients. Our results and our proposed disease model shed new light on the functional pathogenesis of MCI by directing to attentional network disturbances, which could aid new therapeutic strategies and provide a marker for diagnosis and prediction of disease progression.},
  language  = {en}
}
@misc{KrahThulinFaiersteinetal.2019,
  author    = {Krah, Markus and Thulin, Mirjam and Faierstein, Morris M. and Drori, Danielle and Coors, Maria and Schramm, Netta and Driver, Cory and Holzman, Gitit and Zuckermann, Ghil'ad and Fishbane, Eitan P. and Gruenbaum, Caroline and Schirrmeister, Sebastian and Ferrari, Francesco and Stemberger, G{\"u}nter and Schm{\"o}lz-H{\"a}berlein, Michaela and M{\"u}ller, Judith and Schulz, Michael Karl and Meyer, Thomas and Artwińska, Anna and Walter, Simon},
  title     = {PaRDeS : Zeitschrift der Vereinigung f{\"u}r J{\"u}dische Studien = Transformative Translations in Jewish History and Culture},
  number    = {25},
  editor    = {Krah, Markus and Thulin, Mirjam and Pick, Bianca},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-468-5},
  issn      = {1614-6492},
  doi       = {10.25932/publishup-43262},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-432621},
  pages     = {198},
  year      = {2019},
  abstract  = {PaRDeS, die Zeitschrift der Vereinigung f{\"u}r J{\"u}dische Studien e. V., erforscht die fruchtbare kulturelle Vielfalt des Judentums sowie ihre Ber{\"u}hrungspunkte zur nichtj{\"u}dischen Umwelt in unterschiedlichen Bereichen. Daneben dient die Zeitschrift als Forum zur Positionierung der F{\"a}cher J{\"u}dische Studien und ­Judaistik innerhalb des wissenschaftlichen Diskurses sowie zur Diskussion ihrer historischen und gesellschaftlichen Verantwortung.},
  language  = {en}
}
@article{HlinakMuehleWerneretal.2006,
  author    = {Hlinak, Andreas and M{\"u}hle, Ralf-Udo and Werner, Ortrud and Globig, Anja and Starick, Elke and Schirrmeier, Horst and Hoffmann, Bernd and Engelhardt, Andreas and H{\"u}bner, Dagmar and Conraths, Franz J. and Wallschl{\"a}ger, Hans-Dieter and Kruckenberg, Helmut and M{\"u}ller, Thomas},
  title     = {A virological survey in migrating waders and other waterfowl in one of the most important resting sites of Germany},
  issn      = {0931-1793},
  year      = {2006},
  abstract  = {Wild birds are considered a potential reservoir or a carrier of viral diseases and may therefore play a role in the epidemiology of economically important or zoonotic diseases. In 2001 and 2002, a survey with special emphasis oil virus isolation in migrating waders and some other birds were conducted. In one of the most important inland resting sites for migratory waterfowl, tracheal and cloacal swabs were collected from 465 waders representing 19 different species, and 165 other birds that were not captured on purpose. A total of 42 avian viruses were isolated, 34 of these were identified as paramyxoviruses (PMVs). The majority of isolates came from waders and wild ducks, and were characterized as PMV-1. In contrast, PMV-4 was found in wild ducks only, PMV-6 was mainly detected in wader species. Four avian influenza viruses (ATVs), belonging to H4 and H3 haemagglutinin subtype, were isolated from wild duck species. Furthermore, four reo-like viruses were isolated from one particular wader species for the first time. The majority of virus positive birds were < 1 year old and did not show any clinical symptoms. There was no evidence for the presence of West Nile virus in these birds. These results confirm that the restricted resting sites in Western Europe must be considered as important locations for the intra- and interspecies transmission of avian viruses},
  language  = {en}
}
@article{SramaAhrensAltobellietal.2004,
  author    = {Srama, Ralf and Ahrens, Thomas J. and Altobelli, Nicolas and Auer, S. and Bradley, J. G. and Burton, M. and Dikarev, V. V. and Economou, T. and Fechtig, Hugo and G{\"o}rlich, M. and Grande, M. and Graps, Amara and Gr{\"u}n, Eberhard and Havnes, Ove and Helfert, Stefan and Horanyi, Mihaly and Igenbergs, E. and Jessberger, Elmar K. and Johnson, T. V. and Kempf, Sascha and Krivov, Alexander v. and Kr{\"u}ger, Harald and Mocker-Ahlreep, Anna and Moragas-Klostermeyer, Georg and Lamy, Philippe and Landgraf, Markus and Linkert, Dietmar and Linkert, G. and Lura, F. and McDonnell, J. A. M. and Moehlmann, Dirk and Morfill, Gregory E. and Muller, M. and Roy, M. and Schafer, G. and Schlotzhauer, G. and Schwehm, Gerhard H. and Spahn, Frank and St{\"u}big, M. and Svestka, Jiri and Tschernjawski, V},
  title     = {The Cassini Cosmic Dust Analyzer},
  issn      = {0038-6308},
  year      = {2004},
  abstract  = {The Cassini-Huygens Cosmic Dust Analyzer (CDA) is intended to provide direct observations of dust grains with masses between 10(-19) and 10(-9) kg in interplanetary space and in the jovian and saturnian systems, to investigate their physical, chemical and dynamical properties as functions of the distances to the Sun, to Jupiter and to Saturn and its satellites and rings, to study their interaction with the saturnian rings, satellites and magnetosphere. Chemical composition of interplanetary meteoroids will be compared with asteroidal and cometary dust, as well as with Saturn dust, ejecta from rings and satellites. Ring and satellites phenomena which might be effects of meteoroid impacts will be compared with the interplanetary dust environment. Electrical charges of particulate matter in the magnetosphere and its consequences will be studied, e.g. the effects of the ambient plasma and the magnetic held on the trajectories of dust particles as well as fragmentation of particles due to electrostatic disruption. The investigation will be performed with an instrument that measures the mass, composition, electric charge, speed, and flight direction of individual dust particles. It is a highly reliable and versatile instrument with a mass sensitivity 106 times higher than that of the Pioneer 10 and I I dust detectors which measured dust in the saturnian system. The Cosmic Dust Analyzer has significant inheritance from former space instrumentation developed for the VEGA, Giotto, Galileo, and Ulysses missions. It will reliably measure impacts from as low as I impact per month up to 104 impacts per second. The instrument weighs 17 kg and consumes 12 W, the integrated time-of-flight mass spectrometer has a mass resolution of up to 50. The nominal data transmission rate is 524 bits/s and varies between 50 and 4192 bps},
  language  = {en}
}
@inproceedings{PalixLawallThomasetal.2010,
  author    = {Palix, Nicolas and Lawall, Julia L. and Thomas, Ga{\"e}l and Muller, Gilles},
  title     = {How Often do Experts Make Mistakes?},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-41327},
  year      = {2010},
  abstract  = {Large open-source software projects involve developers with a wide variety of backgrounds and expertise. Such software projects furthermore include many internal APIs that developers must understand and use properly. According to the intended purpose of these APIs, they are more or less frequently used, and used by developers with more or less expertise. In this paper, we study the impact of usage patterns and developer expertise on the rate of defects occurring in the use of internal APIs. For this preliminary study, we focus on memory management APIs in the Linux kernel, as the use of these has been shown to be highly error prone in previous work. We study defect rates and developer expertise, to consider e.g., whether widely used APIs are more defect prone because they are used by less experienced developers, or whether defects in widely used APIs are more likely to be fixed.},
  language  = {en}
}
@article{SimonsLewinsohnBluethgenetal.2017,
  author    = {Simons, Nadja K. and Lewinsohn, Thomas and Bluethgen, Nico and Buscot, Francois and Boch, Steffen and Daniel, Rolf and Gossner, Martin M. and Jung, Kirsten and Kaiser, Kristin and M{\"u}ller, J{\"o}rg and Prati, Daniel and Renner, Swen C. and Socher, Stephanie A. and Sonnemann, Ilja and Weiner, Christiane N. and Werner, Michael and Wubet, Tesfaye and Wurst, Susanne and Weisser, Wolfgang W.},
  title     = {Contrasting effects of grassland management modes on species-abundance distributions of multiple groups},
  series = {Agriculture, ecosystems \& environment : an international journal for scientific research on the relationship of agriculture and food production to the biosphere},
  volume    = {237},
  journal   = {Agriculture, ecosystems \& environment : an international journal for scientific research on the relationship of agriculture and food production to the biosphere},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0167-8809},
  doi       = {10.1016/j.agee.2016.12.022},
  pages     = {143 -- 153},
  year      = {2017},
  abstract  = {Intensive land use is a major cause of biodiversity loss, but most studies comparing the response of multiple taxa rely on simple diversity measures while analyses of other community attributes are only recently gaining attention. Species-abundance distributions (SADs) are a community attribute that can be used to study changes in the overall abundance structure of species groups, and whether these changes are driven by abundant or rare species. We evaluated the effect of grassland management intensity for three land-use modes (fertilization, mowing, grazing) and their combination on species richness and SADs for three belowground (arbuscular mycorrhizal fungi, prokaryotes and insect larvae) and seven aboveground groups (vascular plants, bryophytes and lichens; arthropod herbivores; arthropod pollinators; bats and birds). Three descriptors of SADs were evaluated: general shape (abundance decay rate), proportion of rare species (rarity) and proportional abundance of the commonest species (dominance). Across groups, taxonomic richness was largely unaffected by land-use intensity and only decreased with increasing mowing intensity. Of the three SAD descriptors, abundance decay rate became steeper with increasing combined land-use intensity across groups. This reflected a decrease in rarity among plants, herbivores and vertebrates. Effects of fertilization on the three descriptors were similar to the combined land-use intensity effects. Mowing intensity only affected the SAD descriptors of insect larvae and vertebrates, while grazing intensity produced a range of effects on different descriptors in distinct groups. Overall, belowground groups had more even abundance distribtitions than aboveground groups. Strong differences among aboveground groups and between above- and belowground groups indicate that no single taxonomic group can serve as an indicator for effects in other groups. In the past, the use of SADs has been hampered by concerns over theoretical models underlying specific forms of SADs. Our study shows that SAD descriptors that are not connected to a particular model are suitable to assess the effect of land use on community structure.},
  language  = {en}
}
@article{ProbstJakobKaufmannetal.2018,
  author    = {Probst, Thomas and Jakob, Marion and Kaufmann, Yvonne Marie and M{\"u}ller-Neng, Julia M. B. and Bohus, Martin and Weck, Florian},
  title     = {Patients' and therapists' experiences of general change mechanisms during bug-in-the-eye and delayed video-based supervised cognitive-behavioral therapy},
  series = {Journal of clinical psychology},
  volume    = {74},
  journal   = {Journal of clinical psychology},
  number    = {4},
  publisher = {Wiley},
  address   = {Hoboken},
  issn      = {0021-9762},
  doi       = {10.1002/jclp.22519},
  pages     = {509 -- 522},
  year      = {2018},
  abstract  = {ObjectiveThis secondary analysis of a randomized controlled trial investigated whether bug-in-the-eye (BITE) supervision (live computer-based supervision during a psychotherapy session) affects the manner in which patients and therapists experience general change mechanisms (GCMs) during cognitive-behavioral therapy (CBT). MethodA total of 23 therapists were randomized either to the BITE condition or the control condition (delayed video-based [DVB] supervision). After each session, both patients (BITE: n=19; DVB: n=23) and therapists (BITE: n=11; DVB: n=12) completed the Helping Alliance Questionnaire (HAQ) and the Bernese Post Session Report (BPSR). The HAQ total score and the 3 secondary factors of the BPSR (interpersonal experiences, intrapersonal experiences, problem actuation) functioned as GCMs. Multilevel models were performed. ResultsFor patients, GCMs did not develop differently between BITE and DVB during CBT. Therapists rated the alliance as well as interpersonal and intrapersonal experiences not significantly different between BITE and DVB during CBT, but they perceived problem actuation to increase significantly more in BITE than in DVB (p<.05). ConclusionBITE supervision might be helpful in encouraging CBT therapists to apply interventions, which focus on the activation of relevant problems and related emotions.},
  language  = {en}
}
@article{MuellerFoerstendorfSteudtneretal.2019,
  author    = {M{\"u}ller, Katharina and Foerstendorf, Harald and Steudtner, Robin and Tsushima, Satoru and Kumke, Michael Uwe and Lef{\`e}vre, Gr{\´e}gory and Rothe, J{\"o}rg and Mason, Harris and Szab{\´o}, Zolt{\´a}n and Yang, Ping and Adam, Christian K. R. and Andr{\´e}, R{\´e}mi and Brennenstuhl, Katlen and Chiorescu, Ion and Cho, Herman M. and Creff, Ga{\"e}lle and Coppin, Fr{\´e}d{\´e}ric and Dardenne, Kathy and Den Auwer, Christophe and Drobot, Bj{\"o}rn and Eidner, Sascha and Hess, Nancy J. and Kaden, Peter and Kremleva, Alena and Kretzschmar, Jerome and Kr{\"u}ger, Sven and Platts, James A. and Panak, Petra and Polly, Robert and Powell, Brian A. and Rabung, Thomas and Redon, Roland and Reiller, Pascal E. and R{\"o}sch, Notker and Rossberg, Andr{\´e} and Scheinost, Andreas C. and Schimmelpfennig, Bernd and Schreckenbach, Georg and Skerencak-Frech, Andrej and Sladkov, Vladimir and Solari, Pier Lorenzo and Wang, Zheming and Washton, Nancy M. and Zhang, Xiaobin},
  title     = {Interdisciplinary Round-Robin Test on molecular spectroscopy of the U(VI) Acetate System},
  series = {ACS omega / American Chemical Society},
  volume    = {4},
  journal   = {ACS omega / American Chemical Society},
  number    = {5},
  publisher = {American Chemical Society},
  address   = {Washington},
  issn      = {2470-1343},
  doi       = {10.1021/acsomega.9b00164},
  pages     = {8167 -- 8177},
  year      = {2019},
  abstract  = {A comprehensive molecular analysis of a simple aqueous complexing system. U(VI) acetate. selected to be independently investigated by various spectroscopic (vibrational, luminescence, X-ray absorption, and nuclear magnetic resonance spectroscopy) and quantum chemical methods was achieved by an international round-robin test (RRT). Twenty laboratories from six different countries with a focus on actinide or geochemical research participated and contributed to this scientific endeavor. The outcomes of this RRT were considered on two levels of complexity: first, within each technical discipline, conformities as well as discrepancies of the results and their sources were evaluated. The raw data from the different experimental approaches were found to be generally consistent. In particular, for complex setups such as accelerator-based X-ray absorption spectroscopy, the agreement between the raw data was high. By contrast, luminescence spectroscopic data turned out to be strongly related to the chosen acquisition parameters. Second, the potentials and limitations of coupling various spectroscopic and theoretical approaches for the comprehensive study of actinide molecular complexes were assessed. Previous spectroscopic data from the literature were revised and the benchmark data on the U(VI) acetate system provided an unambiguous molecular interpretation based on the correlation of spectroscopic and theoretical results. The multimethodologic approach and the conclusions drawn address not only important aspects of actinide spectroscopy but particularly general aspects of modern molecular analytical chemistry.},
  language  = {en}
}
@misc{LiebeDordevicKaufmannetal.2022,
  author    = {Liebe, Thomas and Dordevic, Milos and Kaufmann, J{\"o}rn and Avetisyan, Araks and Skalej, Martin and M{\"u}ller, Notger Germar},
  title     = {Investigation of the functional pathogenesis of mild cognitive impairment by localisation-based locus coeruleus resting-state fMRI},
  series = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Gesundheitswissenschaftliche Reihe},
  journal   = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Gesundheitswissenschaftliche Reihe},
  number    = {7},
  doi       = {10.25932/publishup-58177},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-581772},
  pages     = {5630 -- 5642},
  year      = {2022},
  abstract  = {Dementia as one of the most prevalent diseases urges for a better understanding of the central mechanisms responsible for clinical symptoms, and necessitates improvement of actual diagnostic capabilities. The brainstem nucleus locus coeruleus (LC) is a promising target for early diagnosis because of its early structural alterations and its relationship to the functional disturbances in the patients. In this study, we applied our improved method of localisation-based LC resting-state fMRI to investigate the differences in central sensory signal processing when comparing functional connectivity (fc) of a patient group with mild cognitive impairment (MCI, n = 28) and an age-matched healthy control group (n = 29). MCI and control participants could be differentiated in their Mini-Mental-State-Examination (MMSE) scores (p < .001) and LC intensity ratio (p = .010). In the fMRI, LC fc to anterior cingulate cortex (FDR p < .001) and left anterior insula (FDR p = .012) was elevated, and LC fc to right temporoparietal junction (rTPJ, FDR p = .012) and posterior cingulate cortex (PCC, FDR p = .021) was decreased in the patient group. Importantly, LC to rTPJ connectivity was also positively correlated to MMSE scores in MCI patients (p = .017). Furthermore, we found a hyperactivation of the left-insula salience network in the MCI patients. Our results and our proposed disease model shed new light on the functional pathogenesis of MCI by directing to attentional network disturbances, which could aid new therapeutic strategies and provide a marker for diagnosis and prediction of disease progression.},
  language  = {en}
}