@book{JankeWuttkeDietschetal.2005, author = {Janke, Thomas and Wuttke, Hans and Dietsch, Volker and Janßen, Martin and K{\"o}nig, Gerhard and Mentzendorff, Arne and Simanowsky, Ursula and Wuttke, Joachim}, title = {Mathematik : Stochastik ; Orientierungswissen Analytische Geometrie ; Gymnasiale Oberstufe, NRW [Sch{\"u}lerbuch]}, publisher = {Cornelsen}, address = {Berlin}, isbn = {3-464-57213-7}, pages = {352 S.}, year = {2005}, language = {de} } @book{JankeWuttkeDietschetal.2005, author = {Janke, Thomas and Wuttke, Hans and Dietsch, Volker and Janßen, Martin and K{\"o}nig, Gerhard and Mentzendorff, Arne and Simanowsky, Ursula and Wuttke, Joachim}, title = {Mathematik : Stochastik ; Handreichungen f{\"u}r den Unterricht ; Gymnasiale Oberstufe [Sch{\"u}lerbuch]}, publisher = {Cornelsen}, address = {Berlin}, isbn = {3-464-57288-9}, pages = {312 S.}, year = {2005}, language = {de} } @book{JankeWuttkeDietschetal.2005, author = {Janke, Thomas and Wuttke, Hans and Dietsch, Volker and Janßen, Martin and K{\"o}nig, Gerhard and Mentzendorff, Arne and Simanowsky, Ursula and Wuttke, Joachim}, title = {Mathematik : Stochastik ; Orientierungswissen Analytische Geometrie ; Handreichungen f{\"u}r den Unterricht ; Gymnasiale Oberstufe NRW [Sch{\"u}lerbuch]}, publisher = {Cornelsen}, address = {Berlin}, isbn = {3-464-57283-8}, pages = {351 S.}, year = {2005}, language = {de} } @article{vonLoeffelholzLieskeNeuschaeferRubeetal.2017, author = {von Loeffelholz, Christian and Lieske, Stefanie and Neuschaefer-Rube, Frank and Willmes, Diana M. and Raschzok, Nathanael and Sauer, Igor M. and K{\"o}nig, J{\"o}rg and Fromm, Martin F. and Horn, Paul and Chatzigeorgiou, Antonios and Pathe-Neuschaefer-Rube, Andrea and Jordan, Jens and Pfeiffer, Andreas F. H. and Mingrone, Geltrude and Bornstein, Stefan R. and Stroehle, Peter and Harms, Christoph and Wunderlich, F. Thomas and Helfand, Stephen L. and Bernier, Michel and de Cabo, Rafael and Shulman, Gerald I. and Chavakis, Triantafyllos and P{\"u}schel, Gerhard Paul and Birkenfeld, Andreas L.}, title = {The human longevity gene homolog INDY and interleukin-6 interact in hepatic lipid metabolism}, series = {Hepatology}, volume = {66}, journal = {Hepatology}, number = {2}, publisher = {Wiley}, address = {Hoboken}, issn = {0270-9139}, doi = {10.1002/hep.29089}, pages = {616 -- 630}, year = {2017}, abstract = {Reduced expression of the Indy ("I am Not Dead, Yet") gene in lower organisms promotes longevity in a manner akin to caloric restriction. Deletion of the mammalian homolog of Indy (mIndy, Slc13a5) encoding for a plasma membrane-associated citrate transporter expressed highly in the liver, protects mice from high-fat diet-induced and aging-induced obesity and hepatic fat accumulation through a mechanism resembling caloric restriction. We studied a possible role of mIndy in human hepatic fat metabolism. In obese, insulin-resistant patients with nonalcoholic fatty liver disease, hepatic mIndy expression was increased and mIndy expression was also independently associated with hepatic steatosis. In nonhuman primates, a 2-year high-fat, high-sucrose diet increased hepatic mIndy expression. Liver microarray analysis showed that high mIndy expression was associated with pathways involved in hepatic lipid metabolism and immunological processes. Interleukin-6 (IL-6) was identified as a regulator of mIndy by binding to its cognate receptor. Studies in human primary hepatocytes confirmed that IL-6 markedly induced mIndy transcription through the IL-6 receptor and activation of the transcription factor signal transducer and activator of transcription 3, and a putative start site of the human mIndy promoter was determined. Activation of the IL-6-signal transducer and activator of transcription 3 pathway stimulated mIndy expression, enhanced cytoplasmic citrate influx, and augmented hepatic lipogenesis in vivo. In contrast, deletion of mIndy completely prevented the stimulating effect of IL-6 on citrate uptake and reduced hepatic lipogenesis. These data show that mIndy is increased in liver of obese humans and nonhuman primates with NALFD. Moreover, our data identify mIndy as a target gene of IL-6 and determine novel functions of IL-6 through mINDY. Conclusion: Targeting human mINDY may have therapeutic potential in obese patients with nonalcoholic fatty liver disease. German Clinical Trials Register: DRKS00005450.}, language = {en} } @article{KoenigFinkeDaimer2007, author = {K{\"o}nig, Thomas and Finke, Daniel and Daimer, Stephanie}, title = {Der Verfassungsvertrag : die beste L{\"o}sung?}, series = {WeltTrends-Papiere}, journal = {WeltTrends-Papiere}, number = {2}, issn = {1864-0656}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-31898}, pages = {62 -- 82}, year = {2007}, abstract = {Inhalt: - Analyserahmen: Effizienz und Transparenz - Option 1: Forcierte Ratifikation - Option 2: Nachverhandlungen eines „Substanz-Vertrags" - Schlussfolgerungen}, language = {de} } @article{KampeKoenigRinkePetzoldtetal.2007, author = {Kampe, Heike and K{\"o}nig-Rinke, Marie and Petzoldt, Thomas and Benndorf, J{\"u}rgen}, title = {Direct effects of Daphnia-grazing, not infochemicals, mediate a shift towards large inedible colonies of the gelatinous green alga Sphaerocystis schroeteri}, issn = {0075-9511}, doi = {10.1016/j.limno.2007.01.001}, year = {2007}, abstract = {The influence of Daphnia galeata x hyalina grazing and of infochemicals released by the daphnids on the colony size and growth rate of the colonial gelatinous green alga Sphaerocystis schroeteri (Chlorococcales) was investigated in laboratory batch experiments run for 96 h. High zooplankton grazing pressure was exerted by a final concentration of 100 daphnids L-1 in the Daphnia treatments. Infochemicals were obtained by filtration (0.2 µm) of water from D. galeata x hyalina cultures (200 ind. L-1 exposed for 24 h). This filtrate was added to the S. schroeteri cultures in two concentrations corresponding to 7 and 50 daphnids L-1, respectively. The growth rate of S. schroeteri was neither affected significantly by direct Daphnia grazing nor by the presence of Daphnia infochemicals in comparison to the control. However, the portion of inedible S. schroeteri colonies (diameter > 50 µm) increased under direct grazing pressure, whereas the Daphnia infochemicals did not influence the colony size significantly. We conclude that the shift in colony size by direct zooplankton grazing denotes an effective defence mechanism against size selective feeding for colonial gelatinous green algae. This effective defence in combination with unchanged growth rates of the larger colonies (under non-limiting nutrient and light conditions) falsifies the assumption of a trade-off between minimising grazing losses and maximising growth by optimising the colony size.}, language = {en} } @article{KoenigPapkeKopyshevetal.2013, author = {K{\"o}nig, Tobias and Papke, Thomas and Kopyshev, Alexey and Santer, Svetlana}, title = {Atomic force microscopy nanolithography fabrication of metallic nano-slits using silicon nitride tips}, series = {Journal of materials science}, volume = {48}, journal = {Journal of materials science}, number = {10}, publisher = {Springer}, address = {New York}, issn = {0022-2461}, doi = {10.1007/s10853-013-7188-x}, pages = {3863 -- 3869}, year = {2013}, abstract = {In this paper, we report on the properties of nano-slits created in metal thin films using atomic force microscope (AFM) nanolithography (AFM-NL). We demonstrate that instead of expensive diamond AFM tips, it is also possible to use low cost silicon nitride tips. It is shown that depending on the direction of scratching, nano-slits of different widths and depths can be fabricated at constant load force. We elucidate the reasons for this behavior and identify an optimal direction and load force for scratching a gold layer.}, language = {en} } @article{AllanBossdorfDormannetal.2014, author = {Allan, Eric and Bossdorf, Oliver and Dormann, Carsten F. and Prati, Daniel and Gossner, Martin M. and Tscharntke, Teja and Bl{\"u}thgen, Nico and Bellach, Michaela and Birkhofer, Klaus and Boch, Steffen and B{\"o}hm, Stefan and B{\"o}rschig, Carmen and Chatzinotas, Antonis and Christ, Sabina and Daniel, Rolf and Diek{\"o}tter, Tim and Fischer, Christiane and Friedl, Thomas and Glaser, Karin and Hallmann, Christine and Hodac, Ladislav and H{\"o}lzel, Norbert and Jung, Kirsten and Klein, Alexandra-Maria and Klaus, Valentin H. and Kleinebecker, Till and Krauss, Jochen and Lange, Markus and Morris, E. Kathryn and M{\"u}ller, J{\"o}rg and Nacke, Heiko and Pasalic, Esther and Rillig, Matthias C. and Rothenwoehrer, Christoph and Schally, Peter and Scherber, Christoph and Schulze, Waltraud X. and Socher, Stephanie A. and Steckel, Juliane and Steffan-Dewenter, Ingolf and T{\"u}rke, Manfred and Weiner, Christiane N. and Werner, Michael and Westphal, Catrin and Wolters, Volkmar and Wubet, Tesfaye and Gockel, Sonja and Gorke, Martin and Hemp, Andreas and Renner, Swen C. and Sch{\"o}ning, Ingo and Pfeiffer, Simone and K{\"o}nig-Ries, Birgitta and Buscot, Francois and Linsenmair, Karl Eduard and Schulze, Ernst-Detlef and Weisser, Wolfgang W. and Fischer, Markus}, title = {Interannual variation in land-use intensity enhances grassland multidiversity}, series = {Proceedings of the National Academy of Sciences of the United States of America}, volume = {111}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, number = {1}, publisher = {National Acad. of Sciences}, address = {Washington}, issn = {0027-8424}, doi = {10.1073/pnas.1312213111}, pages = {308 -- 313}, year = {2014}, abstract = {Although temporal heterogeneity is a well-accepted driver of biodiversity, effects of interannual variation in land-use intensity (LUI) have not been addressed yet. Additionally, responses to land use can differ greatly among different organisms; therefore, overall effects of land-use on total local biodiversity are hardly known. To test for effects of LUI (quantified as the combined intensity of fertilization, grazing, and mowing) and interannual variation in LUI (SD in LUI across time), we introduce a unique measure of whole-ecosystem biodiversity, multidiversity. This synthesizes individual diversity measures across up to 49 taxonomic groups of plants, animals, fungi, and bacteria from 150 grasslands. Multidiversity declined with increasing LUI among grasslands, particularly for rarer species and aboveground organisms, whereas common species and belowground groups were less sensitive. However, a high level of interannual variation in LUI increased overall multidiversity at low LUI and was even more beneficial for rarer species because it slowed the rate at which the multidiversity of rare species declined with increasing LUI. In more intensively managed grasslands, the diversity of rarer species was, on average, 18\% of the maximum diversity across all grasslands when LUI was static over time but increased to 31\% of the maximum when LUI changed maximally over time. In addition to decreasing overall LUI, we suggest varying LUI across years as a complementary strategy to promote biodiversity conservation.}, language = {en} }