@article{CzechWendeMoerletal.2013, author = {Czech, Andreas and Wende, Sandra and Moerl, Mario and Pan, Tao and Ignatova, Zoya}, title = {Reversible and rapid transfer-RNA deactivation as a mechanism of translational repression in stress}, series = {PLoS Genetics : a peer-reviewed, open-access journal}, volume = {9}, journal = {PLoS Genetics : a peer-reviewed, open-access journal}, number = {8}, publisher = {PLoS}, address = {San Fransisco}, issn = {1553-7404}, doi = {10.1371/journal.pgen.1003767}, pages = {9}, year = {2013}, abstract = {Stress-induced changes of gene expression are crucial for survival of eukaryotic cells. Regulation at the level of translation provides the necessary plasticity for immediate changes of cellular activities and protein levels. In this study, we demonstrate that exposure to oxidative stress results in a quick repression of translation by deactivation of the aminoacylends of all transfer-RNA (tRNA). An oxidative-stress activated nuclease, angiogenin, cleaves first within the conserved single-stranded 3'-CCA termini of all tRNAs, thereby blocking their use in translation. This CCA deactivation is reversible and quickly repairable by the CCA-adding enzyme [ATP(CTP): tRNA nucleotidyltransferase]. Through this mechanism the eukaryotic cell dynamically represses and reactivates translation at low metabolic costs.}, language = {en} } @article{HuChengXuetal.2021, author = {Hu, Ting-Li and Cheng, Feng and Xu, Zhen and Chen, Zhong-Zheng and Yu, Lei and Ban, Qian and Li, Chun-Lin and Pan, Tao and Zhang, Bao-Wei}, title = {Molecular and morphological evidence for a new species of the genus Typhlomys (Rodentia: Platacanthomyidae)}, series = {Zoological research : ZR = Dongwuxue-yanjiu : jikan / published by Kunming Institute of Zoology, Chinese Academy of Sciences, Zhongguo Kexueyuan Kunming Dongwu Yanjiusuo zhuban, Dongwuxue-yanjiu Bianji Weiyuanhui bianji}, volume = {42}, journal = {Zoological research : ZR = Dongwuxue-yanjiu : jikan / published by Kunming Institute of Zoology, Chinese Academy of Sciences, Zhongguo Kexueyuan Kunming Dongwu Yanjiusuo zhuban, Dongwuxue-yanjiu Bianji Weiyuanhui bianji}, number = {1}, publisher = {Yunnan Renmin Chubanshe}, address = {Kunming}, issn = {2095-8137}, doi = {10.24272/j.issn.2095-8137.2020.132}, pages = {100 -- 107}, year = {2021}, abstract = {In this study, we reassessed the taxonomic position of Typhlomys (Rodentia: Platacanthomyidae) from Huangshan, Anhui, China, based on morphological and molecular evidence. Results suggested that Typhlomys is comprised of up to six species, including four currently recognized species ( Typhlomys cinereus, T. chapensis, T. daloushanensis, and T. nanus), one unconfirmed candidate species, and one new species ( Typhlomys huangshanensis sp. nov.). Morphological analyses further supported the designation of the Huangshan specimens found at mid-elevations in the southern Huangshan Mountains (600 m to 1 200 m a.s.l.) as a new species.}, language = {en} }