@article{RamiaramanantsoaMoffatHarmonetal.2018,
  author    = {Ramiaramanantsoa, Tahina and Moffat, Anthony F. J. and Harmon, Robert and Ignace, R. and St-Louis, Nicole and Vanbeveren, Dany and Shenar, Tomer and Pablo, Herbert and Richardson, Noel D. and Howarth, Ian D. and Stevens, Ian R. and Piaulet, Caroline and St-Jean, Lucas and Eversberg, Thomas and Pigulski, Andrzej and Popowicz, Adam and Kuschnig, Rainer and Zoclonska, Elzbieta and Buysschaert, Bram and Handler, Gerald and Weiss, Werner W. and Wade, Gregg A. and Rucinski, Slavek M. and Zwintz, Konstanze and Luckas, Paul and Heathcote, Bernard and Cacella, Paulo and Powles, Jonathan and Locke, Malcolm and Bohlsen, Terry and Chen{\´e}, Andr{\´e}-Nicolas and Miszalski, Brent and Waldron, Wayne L. and Kotze, Marissa M. and Kotze, Enrico J. and B{\"o}hm, Torsten},
  title     = {BRITE-Constellation high-precision time-dependent photometry of the early O-type supergiant zeta Puppis unveils the photospheric drivers of its small- and large-scale wind structures},
  series = {Monthly notices of the Royal Astronomical Society},
  volume    = {473},
  journal   = {Monthly notices of the Royal Astronomical Society},
  number    = {4},
  publisher = {Oxford Univ. Press},
  address   = {Oxford},
  issn      = {0035-8711},
  doi       = {10.1093/mnras/stx2671},
  pages     = {5532 -- 5569},
  year      = {2018},
  abstract  = {From 5.5 months of dual-band optical photometric monitoring at the 1 mmag level, BRITE-Constellation has revealed two simultaneous types of variability in the O4I(n)fp star ζ Puppis: one single periodic non-sinusoidal component superimposed on a stochastic component. The monoperiodic component is the 1.78-d signal previously detected by Coriolis/Solar Mass Ejection Imager, but this time along with a prominent first harmonic. The shape of this signal changes over time, a behaviour that is incompatible with stellar oscillations but consistent with rotational modulation arising from evolving bright surface inhomogeneities. By means of a constrained non-linear light-curve inversion algorithm, we mapped the locations of the bright surface spots and traced their evolution. Our simultaneous ground-based multisite spectroscopic monitoring of the star unveiled cyclical modulation of its He ii λ4686 wind emission line with the 1.78-d rotation period, showing signatures of corotating interaction regions that turn out to be driven by the bright photospheric spots observed by BRITE. Traces of wind clumps are also observed in the He ii λ4686 line and are correlated with the amplitudes of the stochastic component of the light variations probed by BRITE at the photosphere, suggesting that the BRITE observations additionally unveiled the photospheric drivers of wind clumps in ζ Pup and that the clumping phenomenon starts at the very base of the wind. The origins of both the bright surface inhomogeneities and the stochastic light variations remain unknown, but a subsurface convective zone might play an important role in the generation of these two types of photospheric variability.},
  language  = {en}
}
@article{KlingstromSoldatovaStevensetal.2013,
  author    = {Klingstrom, Tomas and Soldatova, Larissa and Stevens, Robert and Roos, T. Erik and Swertz, Morris A. and M{\"u}ller, Kristian M. and Kalas, Matus and Lambrix, Patrick and Taussig, Michael J. and Litton, Jan-Eric and Landegren, Ulf and Bongcam-Rudloff, Erik},
  title     = {Workshop on laboratory protocol standards for the molecular methods database},
  series = {New biotechnology},
  volume    = {30},
  journal   = {New biotechnology},
  number    = {2},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1871-6784},
  doi       = {10.1016/j.nbt.2012.05.019},
  pages     = {109 -- 113},
  year      = {2013},
  abstract  = {Management of data to produce scientific knowledge is a key challenge for biological research in the 21st century. Emerging high-throughput technologies allow life science researchers to produce big data at speeds and in amounts that were unthinkable just a few years ago. This places high demands on all aspects of the workflow: from data capture (including the experimental constraints of the experiment), analysis and preservation, to peer-reviewed publication of results. Failure to recognise the issues at each level can lead to serious conflicts and mistakes; research may then be compromised as a result of the publication of non-coherent protocols, or the misinterpretation of published data. In this report, we present the results from a workshop that was organised to create an ontological data-modelling framework for Laboratory Protocol Standards for the Molecular Methods Database (MolMeth). The workshop provided a set of short- and long-term goals for the MolMeth database, the most important being the decision to use the established EXACT description of biomedical ontologies as a starting point.},
  language  = {en}
}
@article{HoulahanCurrieCottenieetal.2007,
  author    = {Houlahan, Jeff E. and Currie, David J. and Cottenie, Karl and Cumming, Graeme S. and Ernest, S. K. Morgan and Findlay, C. Scott and Fuhlendorf, Samuel D. and Gaedke, Ursula and Legendre, Pierre and Magnuson, John J. and McArdle, Brian H. and Muldavin, Esteban H. and Noble, David and Russell, Robert and Stevens, Richard D. and Willis, Trevor J. and Woiwod, Ian P. and Wondzell, Steve M.},
  title     = {Compensatory dynamics are rare in natural ecological communities},
  issn      = {0027-8424},
  doi       = {10.1073/pnas.0603798104},
  year      = {2007},
  abstract  = {In population ecology, there has been a fundamental controversy about the relative importance of competition- driven (density-dependent) population regulation vs. abiotic influences such as temperature and precipitation. The same issue arises at the community level; are population sizes driven primarily by changes in the abundances of cooccurring competitors (i.e., compensatory dynamics), or do most species have a common response to environmental factors? Competitive interactions have had a central place in ecological theory, dating back to Gleason, Volterra, Hutchison and MacArthur, and, more recently, Hubbell's influential unified neutral theory of biodiversity and biogeography. If competitive interactions are important in driving year-to-year fluctuations in abundance, then changes in the abundance of one species should generally be accompanied by compensatory changes in the abundances of others. Thus, one necessary consequence of strong compensatory forces is that, on average, species within communities will covary negatively. Here we use measures of community covariance to assess the prevalence of negative covariance in 41 natural communities comprising different taxa at a range of spatial scales. We found that species in natural communities tended to covary positively rather than negatively, the opposite of what would be expected if compensatory dynamics were important. These findings suggest that abiotic factors such as temperature and precipitation are more important than competitive interactions in driving year-to-year fluctuations in species abundance within communities.},
  language  = {en}
}
@article{HeneghanWardPereraetal.2012,
  author    = {Heneghan, Carl and Ward, Alison and Perera, Rafael and Bankhead, Clare and Fuller, Alice and Stevens, Richard and Bradford, Kairen and Tyndel, Sally and Alonso-Coello, Pablo and Ansell, Jack and Beyth, Rebecca and Bernardo, Artur and Christensen, Thomas Decker and Cromheecke, Manon and Edson, Robert G and Fitzmaurice, David and Gadisseur, Alain PA and Garcia-Alamino, Josep M and Gardiner, Chris and Hasenkam, Michael and Jacobson, Alan and Kaatz, Scott and Kamali, Farhad and Khan, Tayyaba Irfan and Knight, Eve and Kortke, Heinrich and Levi, Marcel and Matchar, David Bruce and Menendez-Jandula, Barbara and Rakovac, Ivo and Schaefer, Christian and Siebenhofer, Andrea and Souto, Juan Carlos and Sunderji, Rubina and Gin, Kenneth and Shalansky, Karen and V{\"o}ller, Heinz and Wagner, Otto and Zittermann, Armin},
  title     = {Self-monitoring of oral anticoagulation systematic review and meta-analysis of individual patient data},
  series = {The lancet},
  volume    = {379},
  journal   = {The lancet},
  number    = {9813},
  publisher = {Elsevier},
  address   = {New York},
  organization    = {Self-Monitoring Trialist Collabora},
  issn      = {0140-6736},
  doi       = {10.1016/S0140-6736(11)61294-4},
  pages     = {322 -- 334},
  year      = {2012},
  abstract  = {Background Uptake of self-testing and self-management of oral coagulation has remained inconsistent, despite good evidence of their effectiveness. To clarify the value of self-monitoring of oral anticoagulation, we did a meta-analysis of individual patient data addressing several important gaps in the evidence, including an estimate of the effect on time to death, first major haemorrhage, and thromboembolism. Methods We searched Ovid versions of Embase (1980-2009) and Medline (1966-2009), limiting searches to randomised trials with a maximally sensitive strategy. We approached all authors of included trials and requested individual patient data: primary outcomes were time to death, first major haemorrhage, and first thromboembolic event. We did prespecified subgroup analyses according to age, type of control-group care (anticoagulation-clinic care vs primary care), self-testing alone versus self-management, and sex. We analysed patients with mechanical heart valves or atrial fibrillation separately. We used a random-effect model method to calculate pooled hazard ratios and did tests for interaction and heterogeneity, and calculated a time-specific number needed to treat. Findings Of 1357 abstracts, we included 11 trials with data for 6417 participants and 12 800 person-years of follow-up. We reported a significant reduction in thromboembolic events in the self-monitoring group (hazard ratio 0.51; 95\% CI 0.31-0.85) but not for major haemorrhagic events (0.88, 0.74-1.06) or death (0.82, 0.62-1.09). Participants younger than 55 years showed a striking reduction in thrombotic events (hazard ratio 0.33, 95\% CI 0.17-0.66), as did participants with mechanical heart valve (0.52, 0.35-0.77). Analysis of major outcomes in the very elderly (age >= 85 years, n=99) showed no significant adverse effects of the intervention for all outcomes. Interpretation Our analysis showed that self-monitoring and self-management of oral coagulation is a safe option for suitable patients of all ages. Patients should also be offered the option to self-manage their disease with suitable health-care support as back-up.},
  language  = {en}
}