@article{PrommerMaurervonWebskyetal.2018,
  author    = {Prommer, Hans-Ulrich and Maurer, Johannes and von Websky, Karoline and Freise, Christian and Sommer, Kerstin and Nasser, Hamoud and Samapati, Rudi and Reglin, Bettina and Guimaraes, Pedro and Pries, Axel Radlach and Querfeld, Uwe},
  title     = {Chronic kidney disease induces a systemic microangiopathy, tissue hypoxia and dysfunctional angiogenesis},
  series = {Scientific reports},
  volume    = {8},
  journal   = {Scientific reports},
  publisher = {Nature Publ. Group},
  address   = {London},
  issn      = {2045-2322},
  doi       = {10.1038/s41598-018-23663-1},
  pages     = {14},
  year      = {2018},
  abstract  = {Chronic kidney disease (CKD) is associated with excessive mortality from cardiovascular disease (CVD). Endothelial dysfunction, an early manifestation of CVD, is consistently observed in CKD patients and might be linked to structural defects of the microcirculation including microvascular rarefaction. However, patterns of microvascular rarefaction in CKD and their relation to functional deficits in perfusion and oxygen delivery are currently unknown. In this in-vivo microscopy study of the cremaster muscle microcirculation in BALB/c mice with moderate to severe uremia, we show in two experimental models (adenine feeding or subtotal nephrectomy), that serum urea levels associate incrementally with a distinct microangiopathy. Structural changes were characterized by a heterogeneous pattern of focal microvascular rarefaction with loss of coherent microvascular networks resulting in large avascular areas. Corresponding microvascular dysfunction was evident by significantly diminished blood flow velocity, vascular tone, and oxygen uptake. Microvascular rarefaction in the cremaster muscle paralleled rarefaction in the myocardium, which was accompanied by a decrease in transcription levels not only of the transcriptional regulator HIF-1 alpha, but also of its target genes Angpt-2, TIE-1 and TIE-2, Flkt-1 and MMP-9, indicating an impaired hypoxia-driven angiogenesis. Thus, experimental uremia in mice associates with systemic microvascular disease with rarefaction, tissue hypoxia and dysfunctional angiogenesis.},
  language  = {en}
}
@misc{Sommer2007,
  type      = {Master Thesis},
  author    = {Sommer, Bettina},
  title     = {Holocaust-Erinnerung und arabisch-israelischer Konflikt : Wechselwirkungen in der israelischen {\"O}ffentlichkeit 2000 - 2006},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-18635},
  school      = {Universit{\"a}t Potsdam},
  year      = {2007},
  abstract  = {In der vorliegenden Diplomarbeit wird untersucht, welchen Einfluss kollektive Erinnerung und offizielle Geschichtsschreibung auf die Bildung kollektiver Identit{\"a}ten haben und speziell auf Israel bezogen, wie und ob aus der Erinnerungskultur an die Shoah Handlungsmotivationen im gegenw{\"a}rtigen Konflikt abgeleitet und diese mit Bezug auf die Shoah legitimiert werden. Der Focus im theoretischen Bereich der Arbeit liegt in erster Linie auf der Entstehung kultureller Ged{\"a}chtnisse und kollektiver Identit{\"a}ten speziell auf den Dynamiken, die sie in Großkollektiven wie Nationen entwickeln, in denen mehrere Erinnerungsdiskurse und Gruppenidentit{\"a}ten der gesamtgesellschaftlichen Integration bed{\"u}rfen. Des weiteren wird der Frage nachgegangen in welchem Verh{\"a}ltnis moderne Geschichtswissenschaft und kollektive Erinnerung zueinander stehen. Ist eine echte Trennung von Geschichtswissenschaft und kollektiver Erinnerung in der gelebten Realit{\"a}t einer Gruppe {\"u}berhaupt m{\"o}glich, vor allem, wenn ihr Gegenstand eine zentrale Rolle im kulturellen Ged{\"a}chtnis des Kollektivs einnimmt und exponiert zur Identit{\"a}tskonstruktion herangezogen wird, wie die Shoah in Israel? Hier schließt sich die Rezeption der Entwicklung der Shoah-Erinnerung in Israel von der Gr{\"u}ndung des Staates bis heute an. Untersucht wird hier, welchen Stellenwert die Erinnerung an die Shoah zu den verschiedenen Zeiten im Selbstbild der j{\"u}dischen Israelis einnahm und warum sie immer wieder Eingang in tagespolitische Diskurse und Entscheidungen fand. Kommt es in Zeiten der {\"a}ußeren Bedrohung durch Selbstmordanschl{\"a}ge oder andere außen- und innenpolitischen Unsicherheitssituationen zu einer verst{\"a}rkten Projektion der Shoah-Erinnerung auf die Gegenwart? Dieser Frage wird im dritten Teil der Arbeit an Hand einer Zeitungsanalyse nachgegangen.},
  language  = {de}
}
@article{MettlerMuehlhausHemmeetal.2014,
  author    = {Mettler, Tabea and M{\"u}hlhaus, Timo and Hemme, Dorothea and Sch{\"o}ttler, Mark Aurel and Rupprecht, Jens and Idoine, Adam and Veyel, Daniel and Pal, Sunil Kumar and Yaneva-Roder, Liliya and Winck, Flavia Vischi and Sommer, Frederik and Vosloh, Daniel and Seiwert, Bettina and Erban, Alexander and Burgos, Asdrubal and Arvidsson, Samuel Janne and Schoenfelder, Stephanie and Arnold, Anne and Guenther, Manuela and Krause, Ursula and Lohse, Marc and Kopka, Joachim and Nikoloski, Zoran and M{\"u}ller-R{\"o}ber, Bernd and Willmitzer, Lothar and Bock, Ralph and Schroda, Michael and Stitt, Mark},
  title     = {Systems analysis of the response of photosynthesis, metabolism, and growth to an increase in irradiance in the photosynthetic model organism chlamydomonas reinhardtii},
  series = {The plant cell},
  volume    = {26},
  journal   = {The plant cell},
  number    = {6},
  publisher = {American Society of Plant Physiologists},
  address   = {Rockville},
  issn      = {1040-4651},
  doi       = {10.1105/tpc.114.124537},
  pages     = {2310 -- 2350},
  year      = {2014},
  abstract  = {We investigated the systems response of metabolism and growth after an increase in irradiance in the nonsaturating range in the algal model Chlamydomonas reinhardtii. In a three-step process, photosynthesis and the levels of metabolites increased immediately, growth increased after 10 to 15 min, and transcript and protein abundance responded by 40 and 120 to 240 min, respectively. In the first phase, starch and metabolites provided a transient buffer for carbon until growth increased. This uncouples photosynthesis from growth in a fluctuating light environment. In the first and second phases, rising metabolite levels and increased polysome loading drove an increase in fluxes. Most Calvin-Benson cycle (CBC) enzymes were substrate-limited in vivo, and strikingly, many were present at higher concentrations than their substrates, explaining how rising metabolite levels stimulate CBC flux. Rubisco, fructose-1,6-biosphosphatase, and seduheptulose-1,7-bisphosphatase were close to substrate saturation in vivo, and flux was increased by posttranslational activation. In the third phase, changes in abundance of particular proteins, including increases in plastidial ATP synthase and some CBC enzymes, relieved potential bottlenecks and readjusted protein allocation between different processes. Despite reasonable overall agreement between changes in transcript and protein abundance (R-2 = 0.24), many proteins, including those in photosynthesis, changed independently of transcript abundance.},
  language  = {en}
}