@article{WyschkonSchulzGallitetal.2017, author = {Wyschkon, Anne and Schulz, Franziska and Gallit, Finja Sunnyi and Poltz, Nadine and Kohn-Henkel, Juliane and Moraske, Svenja and Bondue, Rebecca and von Aster, Michael G. and Esser, G{\"u}nter}, title = {5-Jahres-Verlauf der LRS}, series = {Zeitschrift f{\"u}r Kinder- und Jugendpsychiatrie und Psychotherapie}, volume = {46}, journal = {Zeitschrift f{\"u}r Kinder- und Jugendpsychiatrie und Psychotherapie}, number = {2}, publisher = {Hogrefe}, address = {Bern}, issn = {1422-4917}, doi = {10.1024/1422-4917/a000535}, pages = {107 -- 122}, year = {2017}, abstract = {Fragestellung: Untersucht wird der Verlauf von Kindern mit Lese-Rechtschreibst{\"o}rungen (LRS) {\"u}ber gut 5 Jahre unter Ber{\"u}cksichtigung des Einflusses des Geschlechts der Betroffenen. Außerdem werden Auswirkungen der LRS auf das sp{\"a}tere Schriftsprachniveau und den Schulerfolg {\"u}berpr{\"u}ft. Methodik: Eingangs wurden 995 Sch{\"u}ler zwischen 6 und 16 Jahren untersucht. Ein Teil dieser Kinder ist nach 43 sowie 63 Monaten nachuntersucht worden. Eine LRS wurde diagnostiziert, wenn f{\"u}r das Lesen bzw. Rechtschreiben das doppelte Diskrepanzkriterium von 1.5 Standardabweichungen zur nonverbalen Intelligenz und dem Mittelwert der Klassenstufe erf{\"u}llt war und gleichzeitig keine Minderbegabung vorlag. Ergebnisse: Die LRS weist {\"u}ber einen Zeitraum von 63 Monaten eine hohe St{\"o}rungspersistenz von knapp 70 \% auf. Der 5-Jahres-Verlauf der mittleren Lese- und Rechtschreibleistungen wurde nicht vom Geschlecht beeinflusst. Trotz durchschnittlicher Intelligenz blieben die LRS-Sch{\"u}ler in der Schriftsprache mindestens eine Standardabweichung hinter durchschnittlich und etwa 0.5 Standardabweichungseinheiten hinter unterdurchschnittlich intelligenten Kindern zur{\"u}ck. Der Schulerfolg der LRS-Sch{\"u}ler glich dem unterdurchschnittlich intelligenter Kinder und fiel deutlich schlechter aus als bei durchschnittlich intelligenten Kontrollkindern. Schlussfolgerungen: Eine LRS stellt ein erhebliches Entwicklungsrisiko dar, was fr{\"u}hzeitige Diagnostik- und Therapiemaßnahmen erfordert. Daf{\"u}r sind reliable und im Hinblick auf die resultierenden Pr{\"a}valenzraten sinnvolle, allgemein anerkannte Diagnosekriterien essenziell.}, language = {de} } @article{MeyerSchulzJeibmannetal.2014, author = {Meyer, S{\"o}ren and Schulz, J. and Jeibmann, A. and Taleshi, M. S. and Ebert, Franziska and Francesconi, Kevin A. and Schwerdtle, Tanja}, title = {Arsenic-containing hydrocarbons are toxic in the in vivo model Drosophila melanogaster}, series = {Metallomics : integrated biometal science}, volume = {6}, journal = {Metallomics : integrated biometal science}, number = {11}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, issn = {1756-5901}, doi = {10.1039/c4mt00249k}, pages = {2010 -- 2014}, year = {2014}, abstract = {Arsenic-containing hydrocarbons (AsHC) constitute one group of arsenolipids that have been identified in seafood. In this first in vivo toxicity study for AsHCs, we show that AsHCs exert toxic effects in Drosophila melanogaster in a concentration range similar to that of arsenite. In contrast to arsenite, however, AsHCs cause developmental toxicity in the late developmental stages of Drosophila melanogaster. This work illustrates the need for a full characterisation of the toxicity of AsHCs in experimental animals to finally assess the risk to human health related to the presence of arsenolipids in seafood.}, language = {en} } @misc{MeyerSchulzJeibmannetal.2014, author = {Meyer, S{\"o}ren and Schulz, Jacqueline and Jeibmann, Astrid and Taleshi, Mojtaba S. and Ebert, Franziska and Francesconi, Kevin and Schwerdtle, Tanja}, title = {Arsenic-containing hydrocarbons are toxic in the in vivo model Drosophila melanogaster}, volume = {11}, number = {6}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-76819}, pages = {2010 -- 2014}, year = {2014}, abstract = {Arsenic-containing hydrocarbons (AsHC) constitute one group of arsenolipids that have been identified in seafood. In this first in vivo toxicity study for AsHCs, we show that AsHCs exert toxic effects in Drosophila melanogaster in a concentration range similar to that of arsenite. In contrast to arsenite, however, AsHCs cause developmental toxicity in the late developmental stages of Drosophila melanogaster. This work illustrates the need for a full characterisation of the toxicity of AsHCs in experimental animals to finally assess the risk to human health related to the presence of arsenolipids in seafood.}, language = {en} } @article{MeyerSchulzJeibmannetal.2014, author = {Meyer, S{\"o}ren and Schulz, Jacqueline and Jeibmann, Astrid and Taleshi, Mojtaba S. and Ebert, Franziska and Francesconi, Kevin and Schwerdtle, Tanja}, title = {Arsenic-containing hydrocarbons are toxic in the in vivo model Drosophila melanogaster}, series = {Metallomics}, journal = {Metallomics}, editor = {Schwerdtle, Tanja}, publisher = {The Royal Society of Chemistry}, address = {Cambridge}, issn = {1756-5901}, pages = {2010 -- 2014}, year = {2014}, abstract = {Arsenic-containing hydrocarbons (AsHC) constitute one group of arsenolipids that have been identified in seafood. In this first in vivo toxicity study for AsHCs, we show that AsHCs exert toxic effects in Drosophila melanogaster in a concentration range similar to that of arsenite. In contrast to arsenite, however, AsHCs cause developmental toxicity in the late developmental stages of Drosophila melanogaster. This work illustrates the need for a full characterisation of the toxicity of AsHCs in experimental animals to finally assess the risk to human health related to the presence of arsenolipids in seafood.}, language = {en} } @article{HoffmannDietzelSchulzetal.2011, author = {Hoffmann, Katrin and Dietzel, Birgit and Schulz, Burkhard and Reck, Guenter and Hoffmann, Angelika and Orgzall, Ingo and Resch-Genger, Ute and Emmerling, Franziska}, title = {Combined structural and fluorescence studies of methyl-substituted 2,5-diphenyl-1,3,4-oxadiazoles - Relation between electronic properties and packing motifs}, series = {Journal of molecular structure}, volume = {988}, journal = {Journal of molecular structure}, number = {1-3}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0022-2860}, doi = {10.1016/j.molstruc.2010.11.071}, pages = {35 -- 46}, year = {2011}, abstract = {Prerequisite for the rational design of functional organic materials with tailor-made electronic properties is the knowledge of the structure-property relationship for the specific class of molecules under consideration. This encouraged us to systematically study the influence of the molecular structure and substitution pattern of aromatically substituted 1,3,4-oxadiazoles on the electronic properties and packing motifs of these molecules and on the interplay of these factors. For this purpose, seven diphenyl-oxadiazoles equipped with methyl substituents in the ortho- and meta-position(s) were synthesized and characterized. Absorption and fluorescence spectra in solution served here as tools to monitor substitution-induced changes in the electronic properties of the individual molecules whereas X-ray and optical measurements in the solid state provided information on the interplay of electronic and packing effects. In solution, the spectral position of the absorption maximum, the size of Stokes shift, and the fluorescence quantum yield are considerably affected by ortho-substitution in three or four ortho-positions. This results in blue shifted absorption bands, increased Stokes shifts, and reduced fluorescence quantum yields whereas the spectral position and vibrational structure of the emission bands remain more or less unaffected. In the crystalline state, however, the spectral position and shape of the emission bands display a strong dependence on the molecular structure and/or packing motifs that seem to control the amount of dye-dye-interactions. These observations reveal the limited value of commonly reported absorption and fluorescence measurements in solution for a straightforward comparison of spectroscopic results with single X-ray crystallography. This underlines the importance of solid state spectroscopic studies for a better understanding of the interplay of electronic effects and molecular order.}, language = {en} } @misc{AbramowskiAharonianBenkhalietal.2015, author = {Abramowski, Attila and Aharonian, Felix A. and Benkhali, Faical Ait and Akhperjanian, A. G. and Ang{\"u}ner, Ekrem Oǧuzhan and Backes, Michael and Balenderan, Shangkari and Balzer, Arnim and Barnacka, Anna and Becherini, Yvonne and Tjus, Julia Becker and Berge, David and Bernhard, Sabrina and Bernl{\"o}hr, Konrad and Birsin, E. and Biteau, Jonathan and B{\"o}ttcher, Markus and Boisson, Catherine and Bolmont, J. and Bordas, Pol and Bregeon, Johan and Brun, Francois and Brun, Pierre and Bryan, Mark and Bulik, Tomasz and Carrigan, Svenja and Casanova, Sabrina and Chadwick, Paula M. and Chakraborty, Nachiketa and Chalme-Calvet, R. and Chaves, Ryan C. G. and Chretien, M. and Colafrancesco, Sergio and Cologna, Gabriele and Conrad, Jan and Couturier, Claire and Cui, Yudong and Davids, Isak Delberth and Degrange, Bernhard and Deil, Christoph and deWilt, P. and Djannati-Ata{\"i}, A. and Domainko, Wilfried and Donath, Axel and Dubus, G. and Dutson, K. and Dyks, J. and Dyrda, M. and Edwards, Tanya and Egberts, Kathrin and Eger, Peter and Espigat, P. and Farnier, C. and Fegan, Stephen and Feinstein, Fabrice and Fernandes, Milton Virgilio and Fernandez, Diane and Fiasson, A. and Fontaine, Gerard and F{\"o}rster, Andreas and Fuessling, M. and Gabici, S. and Gajdus, M. and Gallant, Yves A. and Garrigoux, Tania and Giavitto, G. and Giebels, Berrie and Glicenstein, Jean-Francois and Gottschall, Daniel and Grondin, M. -H. and Grudzinska, M. and Hadasch, Daniela and Haeffner, S. and Hahn, Joachim and Harris, Jonathan and Heinzelmann, G{\"o}tz and Henri, G. and Hermann, German and Hervet, O. and Hillert, Andreas and Hinton, James Anthony and Hofmann, Werner and Hofverberg, Petter and Holler, Markus and Horns, Dieter and Ivascenko, Alex and Jacholkowska, A. and Jahn, C. and Jamrozy, Marek and Janiak, M. and Jankowsky, F. and Jung-Richardt, I. and Kastendieck, Max Anton and Katarzynski, K. and Katz, U. and Kaufmann, S. and Khelifi, B. and Kieffer, Michel and Klepser, S. and Klochkov, Dmitry and Kluzniak, W. and Kolitzus, David and Komin, Nu and Kosack, Karl and Krakau, Steffen and Krayzel, F. and Krueger, Pat P. and Laffon, H. and Lamanna, G. and Lefaucheur, J. and Lefranc, Valentin and Lemiere, A. and Lemoine-Goumard, M. and Lenain, J. -P. and Lohse, Thomas and Lopatin, A. and Lu, Chia-Chun and Marandon, Vincent and Marcowith, Alexandre and Marx, Ramin and Maurin, G. and Maxted, Nigel and Mayer, Michael and McComb, T. J. Lowry and Mehault, J. and Meintjes, P. J. and Menzler, Ulf and Meyer, M. and Mitchell, Alison M. W. and Moderski, R. and Mohamed, M. and Mora, K. and Moulin, Emmanuel and Murach, Thomas and de Naurois, Mathieu and Niemiec, J. and Nolan, Sam J. and Oakes, Louise and Odaka, Hirokazu and Ohm, S. and Optiz, Bj{\"o}rn and Ostrowski, Michal and Oya, I. and Panter, Michael and Parsons, R. Daniel and Arribas, M. Paz and Pekeur, Nikki W. and Pelletier, G. and Petrucci, P. -O. and Peyaud, B. and Pita, S. and Poon, Helen and P{\"u}hlhofer, Gerd and Punch, M. and Quirrenbach, A. and Raab, S. and Reichardt, I. and Reimer, Anita and Reimer, Olaf and Renaud, Metz and de los Reyes, Raquel and Rieger, Frank and Romoli, C. and Rosier-Lees, S. and Rowell, G. and Rudak, B. and Rulten, C. B. and Sahakian, Vardan and Salek, D. and Sanchez, David M. and Santangelo, Andrea and Schlickeiser, Reinhard and Schuessler, F. and Schulz, A. and Schwanke, Ullrich and Schwarzburg, S. and Schwemmer, S. and Sol, H. and Spanier, Felix and Spengler, G. and Spies, Franziska and Stawarz, Lukasz and Steenkamp, Riaan and Stegmann, Christian and Stinzing, F. and Stycz, K. and Sushch, Iurii and Tavernet, J. -P. and Tavernier, T. and Taylor, A. M. and Terrier, R. and Tluczykont, Martin and Trichard, C. and Valerius, K. and van Eldik, C. and van Soelen, B. and Vasileiadis, Georges and Veh, J. and Venter, Christo and Viana, Aion and Vincent, P. and Vink, Jacco and V{\"o}lk, Heinrich J. and Volpe, Francesca and Vorster, Martine and Vuillaume, T. and Wagner, S. J. and Wagner, P. and Wagner, R. M. and Ward, Martin and Weidinger, Matthias and Weitzel, Quirin and White, R. and Wierzcholska, A. and Willmann, P. and Woernlein, A. and Wouters, D. and Yang, Ruizhi and Zabalza, Victor and Zaborov, Dmitry and Zacharias, M. and Zdziarski, A. A. and Zech, Alraune and Zechlin, Hannes -S.}, title = {H.E.S.S. detection of TeV emission from the interaction region between the supernova remnant G349.7+0.2 and a molecular cloud (vol 574, A100, 2015)}, series = {Astronomy and astrophysics : an international weekly journal}, volume = {580}, journal = {Astronomy and astrophysics : an international weekly journal}, publisher = {EDP Sciences}, address = {Les Ulis}, organization = {HESS Collaboration}, issn = {1432-0746}, doi = {10.1051/0004-6361/201425070e}, pages = {2}, year = {2015}, language = {en} } @article{EmmerlingOrgzallDietzeletal.2012, author = {Emmerling, Franziska and Orgzall, Ingo and Dietzel, Birgit and Schulz, Burkhard and Larrucea, Julen}, title = {Ordering the amorphous - Structures in PBD LED materials}, series = {Journal of molecular structure}, volume = {1030}, journal = {Journal of molecular structure}, number = {23}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0022-2860}, doi = {10.1016/j.molstruc.2012.04.040}, pages = {209 -- 215}, year = {2012}, abstract = {The class of 2,5 disubstituted-1,3,4-oxadiazoles containing a biphenyl unit on one side is intensively used as electron transport materials to enhance the performance of organic light emitting diodes (OLEDs). In contrast to the ongoing research on these materials insights in their structure-property relationships are still incomplete. To overcome the structural tentativeness and ambiguities the crystal structures of 2-(4-biphenylyl)-5-(4-tert-butylphenyl)-1,3,4-oxadiazole, that of the related compound 2-(4-biphenylyl)-5-phenyl-1,3,4-oxadiazole and of 2-(4-biphenylyl)-5-(2,6-dimethylphenyl)-1,3,4-oxadiazole are determined. A comparison with the results of GAUSSIAN03 calculations and similar compounds in the Cambridge Structural Database leads to a profound characterization.}, language = {en} } @misc{KuehneMeindersMohretal.2016, author = {K{\"u}hne, Franziska and Meinders, C. and Mohr, H. and Hafenbrack, K. and Kieseritzky, K. and Rosenberger, C. and Haerter, M. and Schulz-Kindermann, F. and Klinger, R. and Nestoriuc, A. Y.}, title = {Psychological treatments for pain in cancer patients. A systematic review on the current state of research}, series = {Der Schmerz : Organ der Deutschen Gesellschaft zum Studium des Schmerzes, der {\~A}-sterreichischen Schmerzgesellschaft und der Deutschen Interdisziplin{\~A}\iren Vereinigung f{\~A}¼r Schmerztherapie}, volume = {30}, journal = {Der Schmerz : Organ der Deutschen Gesellschaft zum Studium des Schmerzes, der {\~A}-sterreichischen Schmerzgesellschaft und der Deutschen Interdisziplin{\~A}\iren Vereinigung f{\~A}¼r Schmerztherapie}, publisher = {Springer}, address = {New York}, issn = {0932-433X}, doi = {10.1007/s00482-016-0169-7}, pages = {496 -- 509}, year = {2016}, abstract = {In cancer patients, pain is one of the main symptoms and especially in the late stages of disease, these symptoms can be associated with considerable suffering. In psycho-oncology, preliminary psychological therapies targeting cancer pain have been tested; however, a systematic review of available interventions is lacking, especially considering their dissemination, evidence base, study quality, and the comparison with established treatments. Therefore, the aim of the current study is to systematically review the current research on psychological treatments for pain in cancer patients. During May 2014, MEDLINE, PsycINFO, PSYNDEX, and CENTRAL databases were searched. Psychological treatments for pain in adult cancer patients studied in randomized, controlled trials (RCTs) and referring to pain as primary or secondary outcome were included. After examination for inclusion, structured data extraction and assessment followed. Data were synthesized narratively. In the review, 32 RCTs were included. Studies mainly referred to patients with breast cancer or patients in earlier stages of the disease. The methodological quality of included studies was heterogeneous. Most commonly, short interventions were delivered by nurses in out-patient settings. Interventions including education and relaxation techniques were utilized most often, followed by interventions with behavioral or cognitive components. A need for research persists regarding efficacy of current psychotherapeutic interventions, or the role of mediator variables (e. g., coping) on pain perception in cancer patients. Studies with high methodological quality which comprehensively and transparently report on interventions and designs are lacking.}, language = {de} } @misc{KuehneMeindersMohretal.2017, author = {K{\"u}hne, Franziska and Meinders, C. and Mohr, H. and Hafenbrack, K. and Kieseritzky, K. and Rosenberger, C. and Haerter, M. and Schulz-Kindermann, F. and Klinger, R. and Nestoriuc, A. Y.}, title = {Psychologische Interventionen zur Schmerzreduktion}, series = {Der Schmerz}, volume = {31}, journal = {Der Schmerz}, publisher = {Springer}, address = {New York}, issn = {0932-433X}, doi = {10.1007/s00482-017-0223-0}, pages = {404 -- 404}, year = {2017}, abstract = {Der Leserbrief fokussiert in weiten Teilen auf das Gutachterwesen, weshalb wir ausschließlich auf die inhaltlichen Punkte im Zusammenhang mit unserer Arbeit eingehen. Untersucht wurden schmerzpsychologische Interventionen, wie beschrieben definiert als psychologische Interventionen, deren prim{\"a}res Ziel die Schmerzreduktion war. Die extrahierten Zielgr{\"o}ßen, wie Lebensqualit{\"a}t oder Depressivit{\"a}t, ergaben sich aus den in den Prim{\"a}rstudien untersuchten Hauptoutcomes und nicht aus der Suchstrategie. Zur Einsch{\"a}tzung der methodischen Qualit{\"a}t der Prim{\"a}rstudien konnte ein Kriterium des von Johannsen und Kollegen [2] gebildeten Scores nicht ber{\"u}cksichtigt werden, da die eingeschlossenen Prim{\"a}rstudien keine metaanalytische Zusammenfassung erlaubten. Stellt man dies in Rechnung, bleibt die Vergleichbarkeit beider Werte erhalten. Die Evidenzsynthese erfolgte narrativ in Text- und Tabellenform, d. h. in Form einer strukturierten Zusammenfassung und Diskussion von Studien [1]. Um unsere Arbeit zu fokussieren, h{\"a}tten wir eine weitergehende Gegen{\"u}berstellung wie auch eine {\"U}berpr{\"u}fung von Zitaten und {\"U}bersetzungen selbstverst{\"a}ndlich vorgenommen, wenn wir den Hinweis dazu vor Publikation erhalten h{\"a}tten.}, language = {de} } @misc{SchulzWyschkonGallitetal.2018, author = {Schulz, Franziska and Wyschkon, Anne and Gallit, Finja Sunnyi and Poltz, Nadine and Moraske, Svenja and Kucian, Karin and von Aster, Michael G. and Esser, G{\"u}nter}, title = {Rechenprobleme von Grundschulkindern}, series = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe}, number = {634}, issn = {1866-8364}, doi = {10.25932/publishup-44138}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-441388}, pages = {67 -- 80}, year = {2018}, abstract = {Fragestellung: Ziel war die Untersuchung des Verlaufs von Kindern mit Rechenst{\"o}rungen bzw. Rechenschw{\"a}chen. Neben der Persistenz wurden Auswirkungen von Rechenproblemen auf k{\"u}nftige Rechenleistungen sowie den Schulerfolg gepr{\"u}ft. Methodik: F{\"u}r 2909 Sch{\"u}ler der 2. bis 5. Klasse liegen die Resultate standardisierter Rechen- und Intelligenztests vor. Ein Teil dieser Kinder ist nach 37 und 68 Mona-ten erneut untersucht worden. Ergebnisse: Die Pr{\"a}valenz von Rechenst{\"o}rungen betrug 1.4 \%, Rechenschw{\"a}chen traten bei 11.2 \% auf. Rechen-probleme zeigten eine mittlere bis hohe Persistenz. Sch{\"u}ler mit Rechenschw{\"a}che blieben im Rechnen gut eine Standardabweichung hinter durchschnittlich und ca. eine halbe Standardabweichung hinter unterdurchschnittlich intelligenten Kontrollkindern zur{\"u}ck. Der allgemeine Schulerfolg rechenschwacher Probanden (definiert {\"u}ber Mathematiknote, Deutschnote und Schultyp) {\"a}hnelte dem der unterdurchschnittlich intelligenten Kontrollgruppe und blieb hinter dem Schulerfolg durchschnittlich intelligenter Kontrollkinder zur{\"u}ck. Eingangs {\"a}ltere Probanden mit Rechenproblemen (4. bis 5. Klasse) wiesen eine schlechtere Prognose auf als Kinder, die zu Beginn die 2. oder 3. Klasse besuchten. Schluss-folgerungen: Rechenprobleme stellen ein ernsthaftes Entwicklungsrisiko dar. L{\"a}ngsschnittuntersuchungen, die Kinder mit streng definierter Rechenst{\"o}rung bis ins Erwachsenenalter begleiten und Pr{\"a}diktoren f{\"u}r unterschiedlich erfolgreiche Verl{\"a}ufe ermitteln, sind dringend notwendig.}, language = {de} }