@article{BrietzkeDietzKellingetal.2017, author = {Brietzke, Thomas Martin and Dietz, Thomas and Kelling, Alexandra and Schilde, Uwe and Bois, Juliana and Kelm, Harald and Reh, Manuel and Schmitz, Markus and Koerzdoerfer, Thomas and Leimk{\"u}hler, Silke and Wollenberger, Ulla and Krueger, Hans-Joerg and Holdt, Hans-J{\"u}rgen}, title = {The 1,6,7,12-Tetraazaperylene Bridging Ligand as an Electron Reservoir and Its Disulfonato Derivative as Redox Mediator in an Enzyme-Electrode Process}, series = {Chemistry - a European journal}, volume = {23}, journal = {Chemistry - a European journal}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {0947-6539}, doi = {10.1002/chem.201703639}, pages = {15583 -- 15587}, year = {2017}, abstract = {The homodinuclear ruthenium(II) complex [{Ru(l-N4Me2)}(2)(-tape)](PF6)(4) {[1](PF6)(4)} (l-N4Me2=N,N-dimethyl-2,11-diaza[3.3](2,6)-pyridinophane, tape=1,6,7,12-tetraazaperylene) can store one or two electrons in the energetically low-lying * orbital of the bridging ligand tape. The corresponding singly and doubly reduced complexes [{Ru(l-N4Me2)}(2)(-tape(.-))](PF6)(3) {[2](PF6)(3)} and [{Ru(l-N4Me2)}(2)(-tape(2-))](PF6)(2) {[3](PF6)(2)}, respectively, were electrochemically generated, successfully isolated and fully characterized by single-crystal X-ray crystallography, spectroscopic methods and magnetic susceptibility measurements. The singly reduced complex [2](PF6)(3) contains the -radical tape(.-) and the doubly reduced [3](PF6)(2) the diamagnetic dianion tape(2-) as bridging ligand, respectively. Nucleophilic aromatic substitution at the bridging tape in [1](4+) by two sulfite units gave the complex [{Ru(l-N4Me2)}(2){-tape-(SO3)(2)}](2+) ([4](2+)). Complex dication [4](2+) was exploited as a redox mediator between an anaerobic homogenous reaction solution of an enzyme system (sulfite/sulfite oxidase) and the electrode via participation of the low-energy *-orbital of the disulfonato-substituted bridging ligand tape-(SO3)(2)(2-) (E-red1=-0.1V versus Ag/AgCl/1m KCl in water).}, language = {en} } @misc{SchmitzFuchsvanNimwegenetal.2006, author = {Schmitz, Claudia and Fuchs, Thomas and van Nimwegen, Olaf and Oestmann, Anne and Costello, Vivien and von Schnurbein, Vladimir and Probst, Thomas W. and Maier, Gregor and J{\"o}rgensen, Bent and Krug, Raphael Matthias and L{\"u}dke, Christine and Schmitt, Bernhard and Franz, Matthias and Winter, Martin and Brockfeld, Susanne}, title = {Milit{\"a}r und Gesellschaft in der Fr{\"u}hen Neuzeit}, volume = {10}, number = {1}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, organization = {Arbeitskreis Milit{\"a}r und Gesellschaft in der Fr{\"u}hen Neuzeit e.V. (Hrsg.)}, issn = {1617-9722}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-12626}, year = {2006}, abstract = {Inhalt: Beitr{\"a}ge: Claudia Schmitz: Gewaltanwendung und -wahrnehmung in der fr{\"u}hen Kontaktsituation zwischen Indianern und Europ{\"a}ern, Peru 1532/33 Thomas Fuchs: Von der B{\"u}chersammlung zur Bibliothek. Regimentsbibliotheken des 18. und 19. Jahrhunderts in Hannover Olaf von Nimwegen: The Dutch Army and the Military Revolutions (1588-1688) Anne Oestmann: Billeting in England during the Reign of Charles I, 1625-1649, The Case of Tickhill/Yorkshire Projekte: Vivien Costello: Ein biographisches Lexikon hugenottischer Offiziere in europ{\"a}ischen Armeen 1660-1780 Vladimier von Schnurbein: Die Rolle des Johanniter-Ordens bei der kontinentalen T{\"u}rkenabwehr im 16. Jahrhundert Berichte: Thomas W. Probst: Tagung des Arbeitskreises Milit{\"a}rgeschichte (AKM) 2005, "Kriegsgreuel", 3.-5. November 2005 in Mainz Gregor Maier: Krieg, Milit{\"a}r und Migration in der Fr{\"u}hen Neuzeit. 6. Jahrestagung des Arbeitskreises "Milit{\"a}r und Gesellschaft in der Fr{\"u}hen Neuzeit" gemeinsam mit dem T{\"u}binger Sonderforschungsbereich 437 Bent J{\"o}rgensen, Raphael Matthias Krug, Christine L{\"u}dke: Friedensschl{\"u}sse - Medien im Umfeld der Konfliktbew{\"a}ltigung im Mittelalter und der Fr{\"u}hen Neuzeit Horst Bernhard Schmitt: Milit{\"a}r und Gesellschaft in Herrschaftswechseln Rezensionen Matthias Franz: J{\"o}rg Rathjen: Soldaten im Dorf. L{\"a}ndliche Gesellschaft und Kriege in den Herzogt{\"u}mern Schleswig und Holstein Martin Winter: Peter Engerisser: Von Kronach nach N{\"o}rdlingen. Der Dreißigj{\"a}hrige Krieg in Franken, Schwaben und der Oberpfalz 1631-1635 Ank{\"u}ndigungen Susanne Brockfeld: Staatsbankrott! Bankrotter Staat? Finanzreform und gesellschaftlicher Wandel in Preußen nach 1806. Eine Ausstellung des Geheimen Staatsarchivs Preußischer Kulturbesitz 12. Mai bis 28. Juni 2006 in Berlin Ich dien' nicht! Wehrdienstverweigerung in der Geschichte, Reinbek bei Hamburg, 20. bis 22. Oktober 2006}, language = {de} } @article{deVeraBoettgerdelaTorreNoetzeletal.2012, author = {de Vera, Jean-Pierre Paul and B{\"o}ttger, Ute and de la Torre N{\"o}tzel, Rosa and Sanchez, Francisco J. and Grunow, Dana and Schmitz, Nicole and Lange, Caroline and H{\"u}bers, Heinz-Wilhelm and Billi, Daniela and Baque, Mickael and Rettberg, Petra and Rabbow, Elke and Reitz, G{\"u}nther and Berger, Thomas and M{\"o}ller, Ralf and Bohmeier, Maria and Horneck, Gerda and Westall, Frances and J{\"a}nchen, Jochen and Fritz, J{\"o}rg and Meyer, Cornelia and Onofri, Silvano and Selbmann, Laura and Zucconi, Laura and Kozyrovska, Natalia and Leya, Thomas and Foing, Bernard and Demets, Rene and Cockell, Charles S. and Bryce, Casey and Wagner, Dirk and Serrano, Paloma and Edwards, Howell G. M. and Joshi, Jasmin Radha and Huwe, Bj{\"o}rn and Ehrenfreund, Pascale and Elsaesser, Andreas and Ott, Sieglinde and Meessen, Joachim and Feyh, Nina and Szewzyk, Ulrich and Jaumann, Ralf and Spohn, Tilman}, title = {Supporting Mars exploration BIOMEX in Low Earth Orbit and further astrobiological studies on the Moon using Raman and PanCam technology}, series = {Planetary and space science}, volume = {74}, journal = {Planetary and space science}, number = {1}, publisher = {Elsevier}, address = {Oxford}, issn = {0032-0633}, doi = {10.1016/j.pss.2012.06.010}, pages = {103 -- 110}, year = {2012}, abstract = {The Low Earth Orbit (LEO) experiment Biology and Mars Experiment (BIOMEX) is an interdisciplinary and international space research project selected by ESA. The experiment will be accommodated on the space exposure facility EXPOSE-R2 on the International Space Station (ISS) and is foreseen to be launched in 2013. The prime objective of BIOMEX is to measure to what extent biomolecules, such as pigments and cellular components, are resistant to and able to maintain their stability under space and Mars-like conditions. The results of BIOMEX will be relevant for space proven biosignature definition and for building a biosignature data base (e.g. the proposed creation of an international Raman library). The library will be highly relevant for future space missions such as the search for life on Mars. The secondary scientific objective is to analyze to what extent terrestrial extremophiles are able to survive in space and to determine which interactions between biological samples and selected minerals (including terrestrial, Moon- and Mars analogs) can be observed under space and Mars-like conditions. In this context, the Moon will be an additional platform for performing similar experiments with negligible magnetic shielding and higher solar and galactic irradiation compared to LEO. Using the Moon as an additional astrobiological exposure platform to complement ongoing astrobiological LEO investigations could thus enhance the chances of detecting organic traces of life on Mars. We present a lunar lander mission with two related objectives: a lunar lander equipped with Raman and PanCam instruments which can analyze the lunar surface and survey an astrobiological exposure platform. This dual use of testing mission technology together with geo- and astrobiological analyses will significantly increase the science return, and support the human preparation objectives. It will provide knowledge about the Moon's surface itself and, in addition, monitor the stability of life-markers, such as cells, cell components and pigments, in an extraterrestrial environment with much closer radiation properties to the surface of Mars. The combination of a Raman data base of these data together with data from LEO and space simulation experiments, will lead to further progress on the analysis and interpretation of data that we will obtain from future Moon and Mars exploration missions.}, language = {en} } @article{EndesfelderWeicheltStraussetal.2017, author = {Endesfelder, Stefanie and Weichelt, Ulrike and Strauß, Evelyn and Schl{\"o}r, Anja and Sifringer, Marco and Scheuer, Till and B{\"u}hrer, Christoph and Schmitz, Thomas}, title = {Neuroprotection by caffeine in hyperoxia-induced neonatal brain injury}, series = {International journal of molecular sciences}, volume = {18}, journal = {International journal of molecular sciences}, publisher = {Molecular Diversity Preservation International}, address = {Basel}, issn = {1422-0067}, doi = {10.3390/ijms18010187}, pages = {24}, year = {2017}, abstract = {Sequelae of prematurity triggered by oxidative stress and free radical-mediated tissue damage have coined the term "oxygen radical disease of prematurity". Caffeine, a potent free radical scavenger and adenosine receptor antagonist, reduces rates of brain damage in preterm infants. In the present study, we investigated the effects of caffeine on oxidative stress markers, anti-oxidative response, inflammation, redox-sensitive transcription factors, apoptosis, and extracellular matrix following the induction of hyperoxia in neonatal rats. The brain of a rat pups at postnatal Day 6 (P6) corresponds to that of a human fetal brain at 28-32 weeks gestation and the neonatal rat is an ideal model in which to investigate effects of oxidative stress and neuroprotection of caffeine on the developing brain. Six-day-old Wistar rats were pre-treated with caffeine and exposed to 80\% oxygen for 24 and 48 h. Caffeine reduced oxidative stress marker (heme oxygenase-1, lipid peroxidation, hydrogen peroxide, and glutamate-cysteine ligase catalytic subunit (GCLC)), promoted anti-oxidative response (superoxide dismutase, peroxiredoxin 1, and sulfiredoxin 1), down-regulated pro-inflammatory cytokines, modulated redox-sensitive transcription factor expression (Nrf2/Keap1, and NFκB), reduced pro-apoptotic effectors (poly (ADP-ribose) polymerase-1 (PARP-1), apoptosis inducing factor (AIF), and caspase-3), and diminished extracellular matrix degeneration (matrix metalloproteinases (MMP) 2, and inhibitor of metalloproteinase (TIMP) 1/2). Our study affirms that caffeine is a pleiotropic neuroprotective drug in the developing brain due to its anti-oxidant, anti-inflammatory, and anti-apoptotic properties.}, language = {en} } @misc{EndesfelderWeicheltStraussetal.2017, author = {Endesfelder, Stefanie and Weichelt, Ulrike and Strauß, Evelyn and Schl{\"o}r, Anja and Sifringer, Marco and Scheuer, Till and B{\"u}hrer, Christoph and Schmitz, Thomas}, title = {Neuroprotection by caffeine in hyperoxia-induced neonatal brain injury}, series = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, number = {1097}, issn = {1866-8372}, doi = {10.25932/publishup-47504}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-475040}, pages = {26}, year = {2017}, abstract = {Sequelae of prematurity triggered by oxidative stress and free radical-mediated tissue damage have coined the term "oxygen radical disease of prematurity". Caffeine, a potent free radical scavenger and adenosine receptor antagonist, reduces rates of brain damage in preterm infants. In the present study, we investigated the effects of caffeine on oxidative stress markers, anti-oxidative response, inflammation, redox-sensitive transcription factors, apoptosis, and extracellular matrix following the induction of hyperoxia in neonatal rats. The brain of a rat pups at postnatal Day 6 (P6) corresponds to that of a human fetal brain at 28-32 weeks gestation and the neonatal rat is an ideal model in which to investigate effects of oxidative stress and neuroprotection of caffeine on the developing brain. Six-day-old Wistar rats were pre-treated with caffeine and exposed to 80\% oxygen for 24 and 48 h. Caffeine reduced oxidative stress marker (heme oxygenase-1, lipid peroxidation, hydrogen peroxide, and glutamate-cysteine ligase catalytic subunit (GCLC)), promoted anti-oxidative response (superoxide dismutase, peroxiredoxin 1, and sulfiredoxin 1), down-regulated pro-inflammatory cytokines, modulated redox-sensitive transcription factor expression (Nrf2/Keap1, and NF kappa B), reduced pro-apoptotic effectors (poly (ADP-ribose) polymerase-1 (PARP-1), apoptosis inducing factor (AIF), and caspase-3), and diminished extracellular matrix degeneration (matrix metalloproteinases (MMP) 2, and inhibitor of metalloproteinase (TIMP) 1/2). Our study affirms that caffeine is a pleiotropic neuroprotective drug in the developing brain due to its anti-oxidant, anti-inflammatory, and anti-apoptotic properties.}, language = {en} } @book{BauerBudaeusGruebetal.2008, author = {Bauer, Hartmut and Bud{\"a}us, Dietrich and Gr{\"u}b, Birgit and Schmitz, Heribert and Reichard, Christoph and Mestwerdt, Thomas and Schenke, Ralf P. and Schaedel, Volker and Paffhausen, Peter}, title = {Verwaltungskooperation : Public Private Partnerships und Public Public Partnerships}, editor = {Bauer, Hartmut and B{\"u}chner, Christiane and Brosius-Gersdorf, Frauke}, isbn = {978-3-940793-68-3}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-27583}, publisher = {Universit{\"a}t Potsdam}, year = {2008}, abstract = {Public Private Partnerships (PPP) sind aktueller denn je: Die Aufgaben der Kommunen werden immer komplexer und lassen sich oft nur meistern, wenn die Last auf mehrere Schultern verteilt wird. F{\"u}r die Kommunen bieten PPPs die Chance zu einer schnelleren, b{\"u}rgern{\"a}heren und bedarfsgerechteren Aufgabenerf{\"u}llung, zur Konzentration auf kommunale Kernkompetenzen, zur Nutzung privaten Know-hows sowie zu Kosteneinsparungen und Effizienzgewinnen. F{\"u}r die privaten Partner sind PPPs eine M{\"o}glichkeit zur Erschließung neuer M{\"a}rkte und Generierung lukrativer Auftr{\"a}ge. Gleichzeitig bringen die Planung, die Finanzierung, der Betrieb und die Beendigung {\"O}ffentlich Privater Partnerschaften jedoch komplexe rechtliche und praktische Probleme mit sich. Vor diesem Hintergrund widmete sich die 14. Jahrestagung des Kommunalwissenschaftlichen Institutes (KWI) der Universit{\"a}t Potsdam im April 2008 den rechtlichen Rahmenbedingungen und den praktischen Problemen im allt{\"a}glichen Umgang mit PPPs. Sie beleuchtete die verschiedenen Stationen des Lebenslaufs von PPPs und gab Antworten auf wichtige Fragestellungen bei der Implementierung und Umsetzung von PPP-Projekten. Behandelt wurden unter anderem Themen wie die Novellierung des Vertragsrechts im Verwaltungsverfahrensgesetz, Direktiven des Vergaberechts, M{\"o}glichkeiten der Finanzierung durch EU-F{\"o}rdermittel sowie institutionelle Alternativen (insbes. Public Public Partnerships) und L{\"o}sungswege beim Scheitern von PPPs.}, language = {de} }