@article{WuttkeLiLietal.2019,
  author    = {Wuttke, Matthias and Li, Yong and Li, Man and Sieber, Karsten B. and Feitosa, Mary F. and Gorski, Mathias and Tin, Adrienne and Wang, Lihua and Chu, Audrey Y. and Hoppmann, Anselm and Kirsten, Holger and Giri, Ayush and Chai, Jin-Fang and Sveinbjornsson, Gardar and Tayo, Bamidele O. and Nutile, Teresa and Fuchsberger, Christian and Marten, Jonathan and Cocca, Massimiliano and Ghasemi, Sahar and Xu, Yizhe and Horn, Katrin and Noce, Damia and Van der Most, Peter J. and Sedaghat, Sanaz and Yu, Zhi and Akiyama, Masato and Afaq, Saima and Ahluwalia, Tarunveer Singh and Almgren, Peter and Amin, Najaf and Arnlov, Johan and Bakker, Stephan J. L. and Bansal, Nisha and Baptista, Daniela and Bergmann, Sven and Biggs, Mary L. and Biino, Ginevra and Boehnke, Michael and Boerwinkle, Eric and Boissel, Mathilde and B{\"o}ttinger, Erwin and Boutin, Thibaud S. and Brenner, Hermann and Brumat, Marco and Burkhardt, Ralph and Butterworth, Adam S. and Campana, Eric and Campbell, Archie and Campbell, Harry and Canouil, Mickael and Carroll, Robert J. and Catamo, Eulalia and Chambers, John C. and Chee, Miao-Ling and Chee, Miao-Li and Chen, Xu and Cheng, Ching-Yu and Cheng, Yurong and Christensen, Kaare and Cifkova, Renata and Ciullo, Marina and Concas, Maria Pina and Cook, James P. and Coresh, Josef and Corre, Tanguy and Sala, Cinzia Felicita and Cusi, Daniele and Danesh, John and Daw, E. Warwick and De Borst, Martin H. and De Grandi, Alessandro and De Mutsert, Renee and De Vries, Aiko P. J. and Degenhardt, Frauke and Delgado, Graciela and Demirkan, Ayse and Di Angelantonio, Emanuele and Dittrich, Katalin and Divers, Jasmin and Dorajoo, Rajkumar and Eckardt, Kai-Uwe and Ehret, Georg and Elliott, Paul and Endlich, Karlhans and Evans, Michele K. and Felix, Janine F. and Foo, Valencia Hui Xian and Franco, Oscar H. and Franke, Andre and Freedman, Barry I. and Freitag-Wolf, Sandra and Friedlander, Yechiel and Froguel, Philippe and Gansevoort, Ron T. and Gao, He and Gasparini, Paolo and Gaziano, J. Michael and Giedraitis, Vilmantas and Gieger, Christian and Girotto, Giorgia and Giulianini, Franco and Gogele, Martin and Gordon, Scott D. and Gudbjartsson, Daniel F. and Gudnason, Vilmundur and Haller, Toomas and Hamet, Pavel and Harris, Tamara B. and Hartman, Catharina A. and Hayward, Caroline and Hellwege, Jacklyn N. and Heng, Chew-Kiat and Hicks, Andrew A. and Hofer, Edith and Huang, Wei and Hutri-Kahonen, Nina and Hwang, Shih-Jen and Ikram, M. Arfan and Indridason, Olafur S. and Ingelsson, Erik and Ising, Marcus and Jaddoe, Vincent W. V. and Jakobsdottir, Johanna and Jonas, Jost B. and Joshi, Peter K. and Josyula, Navya Shilpa and Jung, Bettina and Kahonen, Mika and Kamatani, Yoichiro and Kammerer, Candace M. and Kanai, Masahiro and Kastarinen, Mika and Kerr, Shona M. and Khor, Chiea-Chuen and Kiess, Wieland and Kleber, Marcus E. and Koenig, Wolfgang and Kooner, Jaspal S. and Korner, Antje and Kovacs, Peter and Kraja, Aldi T. and Krajcoviechova, Alena and Kramer, Holly and Kramer, Bernhard K. and Kronenberg, Florian and Kubo, Michiaki and Kuhnel, Brigitte and Kuokkanen, Mikko and Kuusisto, Johanna and La Bianca, Martina and Laakso, Markku and Lange, Leslie A. and Langefeld, Carl D. and Lee, Jeannette Jen-Mai and Lehne, Benjamin and Lehtimaki, Terho and Lieb, Wolfgang and Lim, Su-Chi and Lind, Lars and Lindgren, Cecilia M. and Liu, Jun and Liu, Jianjun and Loeffler, Markus and Loos, Ruth J. F. and Lucae, Susanne and Lukas, Mary Ann and Lyytikainen, Leo-Pekka and Magi, Reedik and Magnusson, Patrik K. E. and Mahajan, Anubha and Martin, Nicholas G. and Martins, Jade and Marz, Winfried and Mascalzoni, Deborah and Matsuda, Koichi and Meisinger, Christa and Meitinger, Thomas and Melander, Olle and Metspalu, Andres and Mikaelsdottir, Evgenia K. and Milaneschi, Yuri and Miliku, Kozeta and Mishra, Pashupati P. and Program, V. A. Million Veteran and Mohlke, Karen L. and Mononen, Nina and Montgomery, Grant W. and Mook-Kanamori, Dennis O. and Mychaleckyj, Josyf C. and Nadkarni, Girish N. and Nalls, Mike A. and Nauck, Matthias and Nikus, Kjell and Ning, Boting and Nolte, Ilja M. and Noordam, Raymond and Olafsson, Isleifur and Oldehinkel, Albertine J. and Orho-Melander, Marju and Ouwehand, Willem H. and Padmanabhan, Sandosh and Palmer, Nicholette D. and Palsson, Runolfur and Penninx, Brenda W. J. H. and Perls, Thomas and Perola, Markus and Pirastu, Mario and Pirastu, Nicola and Pistis, Giorgio and Podgornaia, Anna I. and Polasek, Ozren and Ponte, Belen and Porteous, David J. and Poulain, Tanja and Pramstaller, Peter P. and Preuss, Michael H. and Prins, Bram P. and Province, Michael A. and Rabelink, Ton J. and Raffield, Laura M. and Raitakari, Olli T. and Reilly, Dermot F. and Rettig, Rainer and Rheinberger, Myriam and Rice, Kenneth M. and Ridker, Paul M. and Rivadeneira, Fernando and Rizzi, Federica and Roberts, David J. and Robino, Antonietta and Rossing, Peter and Rudan, Igor and Rueedi, Rico and Ruggiero, Daniela and Ryan, Kathleen A. and Saba, Yasaman and Sabanayagam, Charumathi and Salomaa, Veikko and Salvi, Erika and Saum, Kai-Uwe and Schmidt, Helena and Schmidt, Reinhold and Ben Schottker, and Schulz, Christina-Alexandra and Schupf, Nicole and Shaffer, Christian M. and Shi, Yuan and Smith, Albert V. and Smith, Blair H. and Soranzo, Nicole and Spracklen, Cassandra N. and Strauch, Konstantin and Stringham, Heather M. and Stumvoll, Michael and Svensson, Per O. and Szymczak, Silke and Tai, E-Shyong and Tajuddin, Salman M. and Tan, Nicholas Y. Q. and Taylor, Kent D. and Teren, Andrej and Tham, Yih-Chung and Thiery, Joachim and Thio, Chris H. L. and Thomsen, Hauke and Thorleifsson, Gudmar and Toniolo, Daniela and Tonjes, Anke and Tremblay, Johanne and Tzoulaki, Ioanna and Uitterlinden, Andre G. and Vaccargiu, Simona and Van Dam, Rob M. and Van der Harst, Pim and Van Duijn, Cornelia M. and Edward, Digna R. Velez and Verweij, Niek and Vogelezang, Suzanne and Volker, Uwe and Vollenweider, Peter and Waeber, Gerard and Waldenberger, Melanie and Wallentin, Lars and Wang, Ya Xing and Wang, Chaolong and Waterworth, Dawn M. and Bin Wei, Wen and White, Harvey and Whitfield, John B. and Wild, Sarah H. and Wilson, James F. and Wojczynski, Mary K. and Wong, Charlene and Wong, Tien-Yin and Xu, Liang and Yang, Qiong and Yasuda, Masayuki and Yerges-Armstrong, Laura M. and Zhang, Weihua and Zonderman, Alan B. and Rotter, Jerome I. and Bochud, Murielle and Psaty, Bruce M. and Vitart, Veronique and Wilson, James G. and Dehghan, Abbas and Parsa, Afshin and Chasman, Daniel I. and Ho, Kevin and Morris, Andrew P. and Devuyst, Olivier and Akilesh, Shreeram and Pendergrass, Sarah A. and Sim, Xueling and Boger, Carsten A. and Okada, Yukinori and Edwards, Todd L. and Snieder, Harold and Stefansson, Kari and Hung, Adriana M. and Heid, Iris M. and Scholz, Markus and Teumer, Alexander and Kottgen, Anna and Pattaro, Cristian},
  title     = {A catalog of genetic loci associated with kidney function from analyses of a million individuals},
  series = {Nature genetics},
  volume    = {51},
  journal   = {Nature genetics},
  number    = {6},
  publisher = {Nature Publ. Group},
  address   = {New York},
  organization    = {Lifelines COHort Study},
  issn      = {1061-4036},
  doi       = {10.1038/s41588-019-0407-x},
  pages     = {957 -- +},
  year      = {2019},
  abstract  = {Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through transancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these,147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.},
  language  = {en}
}
@article{GoldmannJanietzSchmidtetal.2004,
  author    = {Goldmann, Daniela and Janietz, Dietmar and Schmidt, C. and Wendorff, Joachim Heinz},
  title     = {Columnar liquid crystalline phases through hydrogen bonding and nanoscale segregation},
  issn      = {0959-9428},
  year      = {2004},
  abstract  = {Two columnar phases forming 2,4,6-triarylamino-1,3,5-triazines have been investigated in binary mixtures with calamitic and non-liquid crystalline benzoic acids carrying one or two alkoxy chains at the aromatic core. The triazines form hydrogen bonded aggregates with the complementary acids. Each investigated equimolar mixture exhibits a columnar mesophase due to segregation of the H-bonded polar core region from the lipophilic aliphatic molecular segments. The cross sectional shape of cylindrical aggregates and, therefore, the two-dimensional lattice symmetries, hexagonal or rectangular, are defined by the number of alkoxy chains of the benzoic acid component},
  language  = {en}
}
@article{GoldmannNordsieckJanietzetal.2004,
  author    = {Goldmann, Daniela and Nordsieck, A. and Janietz, Dietmar and Frese, T. and Schmidt, C. and Wendorff, Joachim Heinz},
  title     = {Smectic and columnar liquid crystalline phases through charge-transfer interactions},
  issn      = {1058-725X},
  year      = {2004},
  abstract  = {New heterocyclic electron donors based on. a 1,3,5-triazine nucleus are presented. Three phenyl rings are grafted to the triazine core either via secondary amino groups or by a direct C,C-linkage and a specific number of decyloxy chains is attached to the molecular periphery. The compounds are non-liquid crystalline in their pure states. Lamellar or columnar mesophases are induced by attractive interactions with electron acceptors},
  language  = {en}
}
@article{SchmidtSchuster2016,
  author    = {Schmidt, Daniela and Schuster, Dirk},
  title     = {„Entjudung" - Wort, Ph{\"a}nomen, Programm},
  series = {PaRDeS : Zeitschrift der Vereinigung f{\"u}r J{\"u}dische Studien [22 (2016)] = Muslim-Jewish Dialogue},
  volume    = {22},
  journal   = {PaRDeS : Zeitschrift der Vereinigung f{\"u}r J{\"u}dische Studien [22 (2016)] = Muslim-Jewish Dialogue},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-370-1},
  issn      = {1614-6492},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-99757},
  pages     = {167 -- 191},
  year      = {2016},
  abstract  = {Die Worte „entjuden" und „Entjudung" sind sprachlicher Ausdruck zumeist judenfeindlicher Haltungen und Taten in der deutschen Geschichte. Der Beitrag zeichnet die Entwicklung des Begriffs anhand seiner Verwendungszusammenh{\"a}nge nach. Im Kontext der Assimilation des beginnenden 19. Jahrhunderts meinte der Terminus, dass man sich jener j{\"u}dischen „Eigenheit" zu entkleiden habe, welche als Postulat gemeinhin Konsens war. Innerhalb der innerj{\"u}dischen Diskussion wird „Entjudung" zu Beginn des 20. Jahrhunderts zum diagnostischen Ausdruck des Identit{\"a}tsverlustes. Als politischer Kampfbegriff der Nationalsozialisten ist er wiederum zum Synonym f{\"u}r die Entrechtung und Vernichtung j{\"u}discher Menschen geworden. Protestantische Theologen verwendeten diesen Begriff in der Debatte um die Erneuerung des Christentums, was durch die Entfernung j{\"u}discher Einfl{\"u}sse geschehen sollte. Bereits Ende des 18. Jahrhunderts formuliert, findet diese Forderung in der 1939 erfolgten Gr{\"u}ndung des Instituts zur Erforschung und Beseitigung des j{\"u}dischen Einflusses auf das deutsche kirchliche Leben seine programmatische Umsetzung.},
  language  = {de}
}
@book{VoethHerbstAustenetal.2013,
  author    = {Voeth, Markus and Herbst, Uta and Austen, Viola and Becker, Tatjana and Bertels, Victoria and Heigl, Julia and Huttelmaier, Hannes and Kugler, Aline and Loos, Jeanette and Meister, Christoph and Rentner, Bj{\"o}rn and Richter, Jenny and Schmidt, Natalie and Schwarz, Daniela and schwarz, Sabine},
  title     = {Marketing-Managment : Grundlagen, Konzeption und Umsetzung},
  publisher = {Sch{\"a}ffer-Poeschel Verlag},
  address   = {Stuttgart},
  isbn      = {978-3-7910-3271-9},
  pages     = {684 S.},
  year      = {2013},
  language  = {de}
}
@article{GoldmannMahlstedtJanietzetal.1998,
  author    = {Goldmann, Daniela and Mahlstedt, S. and Janietz, Dietmar and Busch, P. and Schmidt, C. and Stracke, A. and Wendorff, Joachim Heinz},
  title     = {Mesomorphic donor-acceptor twin molecules with covalently linked sheet-like pentaalkyne and nitrofluorenone subunits},
  year      = {1998},
  language  = {en}
}
@article{GoldmannJanietzSchmidtetal.1998,
  author    = {Goldmann, Daniela and Janietz, Dietmar and Schmidt, C. and Wendorff, Joachim Heinz},
  title     = {Liquid crystalline 1,3,5-triazines incorporating rod-like azobenzene sub-units},
  year      = {1998},
  language  = {en}
}
@article{GoldmannJanietzSchmidtetal.1996,
  author    = {Goldmann, Daniela and Janietz, Dietmar and Schmidt, C. and Wendorff, Joachim Heinz},
  title     = {Disc-shaped mesogens based on 1,3,5-triazines : variation and induction of columnar mesophases through complementary intermolecular interactions},
  year      = {1996},
  language  = {en}
}
@article{GoldmannDietelJanietzetal.1998,
  author    = {Goldmann, Daniela and Dietel, Reinhard and Janietz, Dietmar and Schmidt, C. and Wendorff, Joachim Heinz},
  title     = {Sheet-shaped mesogens based on 1,3,5-Triazines : variation of columnar mesophases through intermolecular hydrogen bonding},
  year      = {1998},
  language  = {en}
}
@article{WilkeSchmidtZiemann2015,
  author    = {Wilke, Franziska Daniela Helena and Schmidt, Alexander and Ziemann, Martin Andreas},
  title     = {Subduction, peak and multi-stage exhumation metamorphism: Traces from one coesite-bearing eclogite, Tso Moran, western Himalaya},
  series = {Lithos : an international journal of mineralogy, petrology, and geochemistry},
  volume    = {231},
  journal   = {Lithos : an international journal of mineralogy, petrology, and geochemistry},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0024-4937},
  doi       = {10.1016/j.lithos2015.06.007},
  pages     = {77 -- 91},
  year      = {2015},
  abstract  = {Ultrahigh-pressure (UHP), coesite-bearing edogites in the Himalaya have been documented from the Kaghan Valley in Pakistan and the Tso Morani area in northwest India. These complexes are part of the northern edge of the Indian plate that has been subducted to, and metamorphosed at, mantle depths of more than 100 km before being exhumed. Both UHP complexes are located today directly adjacent to the Indus-Tsangpo suture zone and are not separated by non-metamorphosed sequences of Tethyan sediments from the Asian margin. Herein, we present new data for one fresh coesite-bearing eclogite from the Tso Moran massif. Therein, garnets are zoned reflecting their growth during prograde and peak metamorphism and showing a thin retrograde overgrowth. Inclusions can be directly correlated to the compositional zoning and are seen as either relicts of the protolith mineral paragenesis and as "snap shots" of the mineral paragenesis during subduction and under peak conditions. Rare earth element concentrations (REE) were obtained for garnet, mineral inclusions in garnet and matrix minerals. The REE pattern in garnet reflects a sequential change in matrix minerals and their proportions due to net transfer reactions during subduction and peak metamorphism. Using conventional geothermobarometry, a peak pressure of ca. 44-48 kbar at 560-760 degrees C followed by an S-shaped exhumation curve has been deduced. Gibbs free energy minimization modelling was used to supplement our analytical findings. (C) 2015 Elsevier B.V. All rights reserved.},
  language  = {en}
}
@misc{SaritoprakVorpahlTuranetal.2016,
  author    = {Saritoprak, Zeki and Vorpahl, Daniel and Turan, Hakan and Arslan, Hakki and Zoref, Arye and Tarabieh, Abdallah and Yeshaya, Joachim and Anzi, Menashe and Merkur, Lianne and Schmidt, Daniela and Schuster, Dirk and Langer, Armin and Blum, Rahel and St{\"u}rmann, Jakob and Pohlmann, Julia and Schulz, Michael Karl and Arnold, Rafael D. and Salzer, Dorothea M. and Geißler-Gr{\"u}nberg, Anke and Talabardon, Susanne and Rasumny, Wiebke and Stellmacher, Martha and Denz, Rebekka and Walter, Simon and Gr{\"o}zinger, Elvira},
  title     = {PaRDeS : Zeitschrift der Vereinigung f{\"u}r J{\"u}dische Studien = Muslimisch-J{\"u}discher Dialog},
  series = {PaRDeS : Zeitschrift der Vereinigung f{\"u}r J{\"u}dische Studien e.V.},
  journal   = {PaRDeS : Zeitschrift der Vereinigung f{\"u}r J{\"u}dische Studien e.V.},
  number    = {22},
  editor    = {Riemer, Nathanael and Sanci, Kadir and Schulz, Michael Karl},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-370-1},
  issn      = {1614-6492},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-95416},
  pages     = {280},
  year      = {2016},
  abstract  = {PaRDeS. Zeitschrift der Vereinigung f{\"u}r J{\"u}dische Studien e.V., m{\"o}chte die fruchtbare und facettenreiche Kultur des Judentums sowie seine Ber{\"u}hrungspunkte zur Umwelt in den unterschiedlichen Bereichen dokumentieren. Daneben dient die Zeitschrift als Forum zur Positionierung der F{\"a}cher J{\"u}dische Studien und Judaistik innerhalb des wissenschaftlichen Diskurses sowie zur Diskussion ihrer historischen und gesellschaftlichen Verantwortung.},
  language  = {de}
}
@article{FischerMayerSchollImholtetal.2018,
  author    = {Fischer, Stefan and Mayer-Scholl, Anne and Imholt, Christian and Spierling, Nastasja G. and Heuser, Elisa and Schmidt, Sabrina and Reil, Daniela and Rosenfeld, Ulrike and Jacob, Jens and N{\"o}ckler, Karsten and Ulrich, Rainer G.},
  title     = {Leptospira genomospecies and sequence type prevalence in small mammal populations in Germany},
  series = {Vector-Borne and Zoonotic Diseases},
  volume    = {18},
  journal   = {Vector-Borne and Zoonotic Diseases},
  number    = {4},
  publisher = {Liebert},
  address   = {New Rochelle},
  issn      = {1530-3667},
  doi       = {10.1089/vbz.2017.2140},
  pages     = {188 -- 199},
  year      = {2018},
  abstract  = {Leptospirosis is a worldwide emerging infectious disease caused by zoonotic bacteria of the genus Leptospira. Numerous mammals, including domestic and companion animals, can be infected by Leptospira spp., but rodents and other small mammals are considered the main reservoir. The annual number of recorded human leptospirosis cases in Germany (2001-2016) was 25-166. Field fever outbreaks in strawberry pickers, due to infection with Leptospira kirschneri serovar Grippotyphosa, were reported in 2007 and 2014. To identify the most commonly occurring Leptospira genomospecies, sequence types (STs), and their small mammal host specificity, a monitoring study was performed during 2010-2014 in four federal states of Germany. Initial screening of kidney tissues of 3,950 animals by PCR targeting the lipl32 gene revealed 435 rodents of 6 species and 89 shrews of three species positive for leptospiral DNA. PCR-based analyses resulted in the identification of the genomospecies L. kirschneri (62.7\%), Leptospira interrogans (28.3\%), and Leptospira borgpetersenii (9.0\%), which are represented by four, one, and two STs, respectively. The average Leptospira prevalence was highest (approximate to 30\%) in common voles (Microtus arvalis) and field voles (Microtus agrestis). Both species were exclusively infected with L. kirschneri. In contrast, in bank voles (Myodes glareolus) and yellow-necked mice (Apodemus flavicollis), DNA of all three genomospecies was detected, and in common shrews (Sorex araneus) DNA of L. kirschneri and L. borgpetersenii was identified. The association between individual infection status and demographic factors varied between species; infection status was always positively correlated to body weight. In conclusion, the study confirmed a broad geographical distribution of Leptospira in small mammals and suggested an important public health relevance of common and field voles as reservoirs of L. kirschneri. Furthermore, the investigations identified seasonal, habitat-related, as well as individual influences on Leptospira prevalence in small mammals that might impact public health.},
  language  = {en}
}
@article{SchmidtReilJeskeetal.2021,
  author    = {Schmidt, Sabrina and Reil, Daniela and Jeske, Kathrin and Drewes, Stephan and Rosenfeld, Ulrike and Fischer, Stefan and Spierling, Nastasja G. and Labutin, Anton and Heckel, Gerald and Jacob, Jens and Ulrich, Rainer G. and Imholt, Christian},
  title     = {Spatial and temporal dynamics and molecular evolution of Tula orthohantavirus in German vole populations},
  series = {Viruses / Molecular Diversity Preservation International (MDPI)},
  volume    = {13},
  journal   = {Viruses / Molecular Diversity Preservation International (MDPI)},
  number    = {6},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {1999-4915},
  doi       = {10.3390/v13061132},
  pages     = {17},
  year      = {2021},
  abstract  = {Tula orthohantavirus (TULV) is a rodent-borne hantavirus with broad geographical distribution in Europe. Its major reservoir is the common vole (Microtus arvalis), but TULV has also been detected in closely related vole species. Given the large distributional range and high amplitude population dynamics of common voles, this host-pathogen complex presents an ideal system to study the complex mechanisms of pathogen transmission in a wild rodent reservoir. We investigated the dynamics of TULV prevalence and the subsequent potential effects on the molecular evolution of TULV in common voles of the Central evolutionary lineage. Rodents were trapped for three years in four regions of Germany and samples were analyzed for the presence of TULV-reactive antibodies and TULV RNA with subsequent sequence determination. The results show that individual (sex) and population-level factors (abundance) of hosts were significant predictors of local TULV dynamics. At the large geographic scale, different phylogenetic TULV clades and an overall isolation-by-distance pattern in virus sequences were detected, while at the small scale (<4 km) this depended on the study area. In combination with an overall delayed density dependence, our results highlight that frequent, localized bottleneck events for the common vole and TULV do occur and can be offset by local recolonization dynamics.},
  language  = {en}
}
@misc{ReilRosenfeldImholtetal.2017,
  author    = {Reil, Daniela and Rosenfeld, Ulrike and Imholt, Christian and Schmidt, Sabrina and Ulrich, Rainer G. and Eccard, Jana and Jacob, Jens},
  title     = {Puumala hantavirus infections in bank vole populations},
  series = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  journal   = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  number    = {957},
  issn      = {1866-8372},
  doi       = {10.25932/publishup-43123},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-431232},
  pages     = {15},
  year      = {2017},
  abstract  = {Background In Europe, bank voles (Myodes glareolus) are widely distributed and can transmit Puumala virus (PUUV) to humans, which causes a mild to moderate form of haemorrhagic fever with renal syndrome, called nephropathia epidemica. Uncovering the link between host and virus dynamics can help to prevent human PUUV infections in the future. Bank voles were live trapped three times a year in 2010-2013 in three woodland plots in each of four regions in Germany. Bank vole population density was estimated and blood samples collected to detect PUUV specific antibodies. Results We demonstrated that fluctuation of PUUV seroprevalence is dependent not only on multi-annual but also on seasonal dynamics of rodent host abundance. Moreover, PUUV infection might affect host fitness, because seropositive individuals survived better from spring to summer than uninfected bank voles. Individual space use was independent of PUUV infections. Conclusions Our study provides robust estimations of relevant patterns and processes of the dynamics of PUUV and its rodent host in Central Europe, which are highly important for the future development of predictive models for human hantavirus infection risk.},
  language  = {en}
}
@article{FischerSpierlingHeuseretal.2018,
  author    = {Fischer, Stefan and Spierling, Nastasja G. and Heuser, Elisa and Kling, Christopher and Schmidt, Sabrina and Rosenfeld, Ulrike and Reil, Daniela and Imholt, Christian and Jacob, Jens and Ulrich, Rainer G. and Essbauer, Sandra},
  title     = {High prevalence of Rickettsia helvetica in wild small mammal populations in Germany},
  series = {Ticks and Tick-borne Diseases},
  volume    = {9},
  journal   = {Ticks and Tick-borne Diseases},
  number    = {3},
  publisher = {Elsevier GMBH},
  address   = {M{\"u}nchen},
  issn      = {1877-959X},
  doi       = {10.1016/j.ttbdis.2018.01.009},
  pages     = {500 -- 505},
  year      = {2018},
  abstract  = {Since the beginning of the 21st century, spotted fever rickettsioses are known as emerging diseases worldwide. Rickettsiae are obligately intracellular bacteria transmitted by arthropod vectors. The ecology of Rickettsia species has not been investigated in detail, but small mammals are considered to play a role as reservoirs. Aim of this study was to monitor rickettsiae in wild small mammals over a period of five years in four federal states of Germany. Initial screening of ear pinna tissues of 3939 animals by Pan-Rick real-time PCR targeting the citrate synthase (gltA) gene revealed 296 rodents of seven species and 19 shrews of two species positive for rickettsial DNA. Outer membrane protein gene (ompB, ompAIV) PCRs based typing resulted in the identification of three species: Rickettsia helvetica (90.9\%) was found as the dominantly occurring species in the four investigated federal states, but Rickettsia felis (7.8\%) and Rickettsia raoultii (1.3\%) were also detected. The prevalence of Rickettsia spp. in rodents of the genus Apodemus was found to be higher (approximately 14\%) than in all other rodent and shrew species at all investigated sites. General linear mixed model analyses indicated that heavier (older) individuals of yellow-necked mice and male common voles seem to contain more often rickettsial DNA than younger ones. Furthermore, rodents generally collected in forests in summer and autumn more often carried rickettsial DNA. In conclusion, this study indicated a high prevalence of R. helvetica in small mammal populations and suggests an age-dependent increase of the DNA prevalence in some of the species and in animals originating from forest habitats. The finding of R. helvetica and R. felis DNA in multiple small mammal species may indicate frequent trans-species transmission by feeding of vectors on different species. Further investigations should target the reason for the discrepancy between the high rickettsial DNA prevalence in rodents and the so far almost absence of clinical apparent human infections.},
  language  = {en}
}
@article{ReilRosenfeldImholtetal.2017,
  author    = {Reil, Daniela and Rosenfeld, Ulrike and Imholt, Christian and Schmidt, Sabrina and Ulrich, Rainer G. and Eccard, Jana and Jacob, Jens},
  title     = {Puumala hantavirus infections in bank vole populations},
  series = {BMC ecology},
  volume    = {17},
  journal   = {BMC ecology},
  publisher = {BioMed Central},
  address   = {London},
  issn      = {1472-6785},
  doi       = {10.1186/s12898-017-0118-z},
  pages     = {13},
  year      = {2017},
  abstract  = {Background In Europe, bank voles (Myodes glareolus) are widely distributed and can transmit Puumala virus (PUUV) to humans, which causes a mild to moderate form of haemorrhagic fever with renal syndrome, called nephropathia epidemica. Uncovering the link between host and virus dynamics can help to prevent human PUUV infections in the future. Bank voles were live trapped three times a year in 2010-2013 in three woodland plots in each of four regions in Germany. Bank vole population density was estimated and blood samples collected to detect PUUV specific antibodies. Results We demonstrated that fluctuation of PUUV seroprevalence is dependent not only on multi-annual but also on seasonal dynamics of rodent host abundance. Moreover, PUUV infection might affect host fitness, because seropositive individuals survived better from spring to summer than uninfected bank voles. Individual space use was independent of PUUV infections. Conclusions Our study provides robust estimations of relevant patterns and processes of the dynamics of PUUV and its rodent host in Central Europe, which are highly important for the future development of predictive models for human hantavirus infection risk},
  language  = {en}
}